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141. The impact of care farms on quality of life, depression and anxiety among different population groups: A systematic review Full Text available with Trip Pro

calm environment that is nonconfrontational and offers structure and space for people to channel their energies into tasks that are mentally relaxing could provide a good fit for those who are unable to benefit from more conventional services. Disengaged or disaffected children, defined as those who are not fully taking part in school life as they have given up trying or are resisting help (Lumby, ), are at high risk of exclusion from school. Exclusion from school can predispose young people

2019 Campbell Collaboration

142. Incentives for climate mitigation in the land use sector—the effects of payment for environmental services on environmental and socioeconomic outcomes in low? and middle?income countries: A mixed?methods systematic review Full Text available with Trip Pro

wider benefits for society. The theory assumes that the conservation payments outweigh the benefits derived from business as usual, such as converting forests to agricultural uses, or harvesting wood for energy. PES may have positive or negative spill‐over effects on land that is not enroled in the programme. If households or communities do not enrol all their land in a programme, resource exploitation pressures may simply move on to the nonenroled areas, known as leakage or substitution effects (...) in, or exploit land (Ferraro, ). There may be negative environmental consequences when payments to participating families allow them to overcome these constraints to make investments in unenrolled land, or enroled land once payments stop, that result in less environmentally favourable land uses. 3.4 Why it is important to do the review 3.4.1 Review of existing literature There is an emerging impact evaluation literature on PES programmes. A 3ie evidence gap map (EGM) published in 2016 identified 41 4

2019 Campbell Collaboration

143. Consensus Practice Guidelines on Interventions for Lumbar Facet Joint Pain from a Multispecialty, International Working Group Full Text available with Trip Pro

with the recommendations of multiple CPGs; grade C recommendation, low level of evidence. Question 4: is image guidance necessary for lumbar facet blocks and radiofrequency ablation? Theoretical concerns: accuracy and safety Image guidance has become an essential component of performing spinal procedures in pain management. For MBB and IA facet joint injections, fluoroscopy and to a lesser degree, CT guidance are most commonly used. The use of imaging allows accurate needle placement ensuring the lowest volume (...) facet blocks. Success rates exceeding 90% have been reported by other investigators as well. Despite its high-resolution compared with plain radiographs, the use of CT blocks for MBB and RFA has not been demonstrated in randomized clinical trials. For MBB, CT precludes the use of real-time contrast injection or digital subtraction angiography to detect intravascular uptake. Regarding RFA, the use of CT is limited because of imaging constraints and radiation exposure. Fluoroscopy allows

2020 American Society of Regional Anesthesia and Pain Medicine

145. Early breast cancer (preventing recurrence and improving survival): adjuvant bisphosphonates

of bisphosphonate treatment for preventing recurrence and improving survival in women with early breast cancer is unclear. Based on the evidence from the meta-analysis, the CCO/ASCO guideline generally recommends intravenous zoledronic acid (4 mg every 6 months for 3–5 years) or oral clodronate (1,600 mg daily for 2–3 years) for postmenopausal women with breast cancer deemed candidates for adjuvant bisphosphonate therapy (in addition to standard breast cancer treatments). The European consensus guideline also (...) recommends 6-monthly intravenous zoledronic acid or daily oral clodronate for preventing metastases and improving disease outcomes in postmenopausal women with early breast cancer. There is less evidence to support the use of monthly intravenous zoledronic acid and daily oral ibandronic acid, and little or no evidence to support the use of risedronate and alendronic acid. Different adverse effect profiles, frequency and route of administration, and cost may affect the choice of treatment. The EBCTCG meta

2017 National Institute for Health and Clinical Excellence - Advice

146. Obese, overweight with risk factors: liraglutide (Saxenda)

-related comorbidity such as dysglycaemia (prediabetes or type 2 diabetes mellitus), hypertension, dyslipidaemia or obstructive sleep apnoea. Treatment should be discontinued after 12 weeks on the 3.0 mg daily dose (recommended maintenance dose) if patients have not lost at least 5% of their initial body weight. Liraglutide (Saxenda) is a different licensed product to liraglutide (Victoza) and the doses of liraglutide (Saxenda) used for weight management are different to that used in managing type 2 (...) were obese or overweight (BMI 27 kg/m² or above) with a variety of weight-related co-morbidities including dyslipidaemia, hypertension, type 2 diabetes and obstructive sleep apnoea. All of these studies compared liraglutide 3.0 mg daily with placebo and all participants also received lifestyle interventions for weight loss. There are currently no published double blind RCTs which compare liraglutide with other medicines for weight management. The main efficacy outcomes from the 4 studies included

2017 National Institute for Health and Clinical Excellence - Advice

147. Bictegravir/emtricitabine/tenofovir alafenamide (Biktarvy) adults infected with human immunodeficiency virus-1 (HIV-1)

product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. Current clinical practice Guidelines recommend that antiretroviral therapy (ART) in treatment-naïve patients with HIV-1 consists of two nucleoside reverse transcriptase inhibitors (NRTIs) plus either integrase inhibitor, ritonavir-boosted protease inhibitor or non-NRTI. The company anticipates that Biktarvy ® (...) antiretroviral component 4 . 2.2 Medicine Bictegravir/emtricitabine/tenofovir alafenamide (Biktarvy ® ) is a fixed dose combination product for once daily administration for the treatment of adults infected with HIV-1 without present or past evidence of viral resistance to the integrase inhibitor class, emtricitabine or tenofovir (June 2018) 5 . The applicant company anticipates that Biktarvy ® will be used in place of alternative integrase inhibitor-based single tablet regimens as either a first-line

2018 All Wales Medicines Strategy Group

148. Ekso exoskeleton for rehabilitation in people with neurological weakness or paralysis

in rehabilitation activities for people who have weak or paralysed legs and sufficient arm strength to use crutches. It is intended to help people to relearn to stand and walk. The inno innovativ vative aspect e aspect is the SmartAssist software that is incorporated in the device. This allows physiotherapists to set the power for each leg independently to best suit the user. Multiple patients can use each Ekso GT robotic exoskeleton, with it being adapted to their specific needs. The intended place in ther (...) a computer, battery and a wired controller (Kozlowski 2015). The exoskeleton is attached to the body by a series of straps set at a specific distance to ensure stability according to the patient's weight (Nitschke 2013). Ekso incorporates proprietary SmartAssist software, which allows the physiotherapist to set the power for each leg independently to best suit the user. Ekso can be used for more than 1 user and can be adapted to individual patients' specific needs. Settings for each user can be saved

2017 National Institute for Health and Clinical Excellence - Advice

149. Mitochondrial disorders in children: Co-enzyme Q10

of outcomes assessed including mitochondrial disease-specific activities of daily living and quality of life assessment scores, handgrip fatigue tests and sustained endurance strength. However, the studies had a number of important methodological limitations, were of short duration and included only small numbers of participants. They may therefore have been insufficiently powered to detect any true differences between placebo and co-enzyme Q10. In the non-randomised study, after 6 months treatment (...) disorders in children: Co-enzyme Q10 (ES11) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 59Effectiv Effectiveness eness No statistically significant difference between co-enzyme Q10 at a dose of 600 mg twice daily and placebo for mitochondrial disease-specific activities of daily living and quality of life assessment scores or mean maximal isometric forearm strength (Glover et al. 2010, RCT in adults; n=30

2017 National Institute for Health and Clinical Excellence - Advice

150. Risk Factors for Endometrial Cancer - A review of the evidence

organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and retain this copyright notice and all disclaimer notices as part of that reproduction. Apart from rights to use as permitted by the Copyright Act 1968 or allowed by this copyright notice, all other rights are reserved and you are not allowed to reproduce the whole or any part of this work in any way (electronic or otherwise) without first being given the specific written permission from Cancer (...) Bibliographic searches were performed on the Cochrane Library and Medline via OVID using MeSH terms and free text words: Endometrial cancer risk factors: a review of the evidence 12 Search date 8 January 2018 Ovid MEDLINE(R) Epub Ahead of Print, In –Process & Other Non –Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R) 1946 to Present (maligna$ or cancer$ or carcinoma or tumo?r).ti,ab. (endomet$ or corpus uteri or uterine or uterus).ti,ab. (risk or prognos$ or predict$ or inciden$ or associate

2019 Cancer Australia

151. Qualitative evidence on barriers to and facilitators of women’s participation in higher or growing productivity and male-dominated labour market sectors in low- and middle-income countries

Following a comprehensive search strategy, of the 216 studies that appeared possibly relevant from their titles and abstracts, on further inspection of the full reports, 37 provided no detail on labour market outcomes in high growth or male dominated sectors. Those that did focused on commercial agriculture (49%), trade (31%), business administration services (17%), energy including mining (16%), accommodation and food (11%), finance (6%), and transportation (3%). Other studies were unable to contribute (...) to answering the review question because they did not address low or lower-middle income countries (38), and or were not qualitative studies (101) and therefore were unable to provide explanations about barriers or facilitators. A further 22 were excluded because they were not of high nor medium quality. This allowed the synthesis effort to be focused on the 18 studies that both fell within the review’s scope and used research methods with high or medium rigour to elicit participants’ experiences. The 18

2019 EPPI Centre

152. Public health service provision by community pharmacies: a systematic map of evidence

of contact with a healthcare professional (PSNC 2013). The role of the community pharmacist has changed substantially over recent years, and they are now considered an important part of the structural landscape of our health services. CPs usually offer convenient opening times, including evening and weekends, allowing access for people who work a range of hours. They are often well placed, geographically, to access groups that services are not otherwise reaching (LGA 2014; PSNC 2013). It has been shown

2019 EPPI Centre

153. Stepping Stones for Families’ Family Wellbeing Service: evaluation

of the parents interviewed talked about feeling socially isolated, with nursery and SSfF staff also very aware of this as an issue. It was striking that these feelings of social isolation were present in parents with partners as well as those without. Feelings of isolation were felt to have been triggered by a range of different circumstances. Parents reported that they had lost friends when they became mothers, with their time and energy focused on their children, leaving them neither energy nor opportunity (...) parents to apply for grants from charitable trusts, for example to provide a new carpet, or a new freezer without which a parent was doing expensive daily shops. ? Helping parents access a mobility car and accompanying them on a couple of drives to give them the confidence to use it. ? Helping asylum seeking families access their bus passes. ? Accompanying parents with health problems to reviews of their employment situation. ? Pushing social landlords to resolve repairs to parents’ accommodation

2019 Glasgow Centre for Population Health

154. Guidance on the clinical management of anxiety disorders, specifically focusing on diagnosis and treatment strategies

daily role for less than 1 day per month, 1–7 days per month and more than 7 days per month, respectively. This classification is based on the distribution of number of complete days out of role reported by people in the Australian National Survey of Mental Health and Wellbeing (Slade et al., 2009b) who met criteria for one or more of panic disorder, SAD or GAD. # Medication should be combined with advice about graded exposure to feared situations. †Review after 4–6 sessions of weekly CBT, or after (...) or GAD; • • Papers with level I evidence for intervention studies (i.e. meta-analyses or systematic reviews of ran- domised controlled trials [RCTs]); • • Papers published in English. Studies were excluded if the focus was not on the rele- vant disorders or if insufficient details were provided to allow synthesis. For each included study, the level of evidence was assessed according to the Australian National Health and Medical Research Council (NHMRC) classification for intervention studies (Table 1

2018 Royal Australian and New Zealand College of Psychiatrists

155. Integrating money advice workers into primary care settings: an evaluation

on to other support services. The nine practices achieved the equivalent of more than half of the 1,264 referrals achieved under the ‘locality model’, over a similar 12 month period. The established locality model allows healthcare professionals to refer people to advice services based in seven health centres across northeast Glasgow. There were 71 locality referrals from 35 GP practices over this period, in sharp contrast to 654 from the nine practices testing this integrated approach. Demand for advice (...) , such as having access to medical evidence and drafting letters signed off by the GP to be used at benefits reviews and appeals. The workers viewed practices as a ‘trusted hub’ that could help reduce stigma and encourage people to be more open about their money worries. The project benefits included some practice staff reporting an easing of workload and reduction in welfare-related appointments, new working relationships that allowed staff to directly refer to advice workers, and a subsequent increase in GPs

2019 Glasgow Centre for Population Health

156. Bariatric surgery: an HTA report on the efficacy, safety and cost-effectiveness

-term survival benefit after bariatric surgery. However, such studies are prone to bias (e.g. possible selection of healthier or more motivated patients) and do not allow to make firm conclusions. The evaluation of the effect of MBS on long-term mortality, is based on systemic review and meta-analyses of studies that are essentially of observational nature. They are complemented with some other data from recently published registry based cohort-studies. The data from these sources show in general

2019 Belgian Health Care Knowledge Centre

157. Older people in care homes: Sex, Sexuality and Intimate Relationships

or disability, general tiredness, weakness or malaise leading to reduced energy available for self-care or social activities • common health problems – such as constipation, bladder weakness or chronic pain which can affect every day functioning and intimate relationships • loss of independence, reliance on others for help leading to lack of privacy in everyday surroundings • the personal impact of moving into a care home, leaving one’s home and the security of familiar surroundings and treasured (...) specialist help and health care services when appropriate. III Specific suggestions This level of working encompasses working with the client group and having a general understanding of the impact of illness or disability on their daily lives, but also a specific knowledge of sexual wellbeing, sexual health and OLDER PEOPLE IN CARE HOMES: SEX, SEXUALITY AND INTIMATE RELATIONSHIPS 12 sexual functioning. Establishing a therapeutic relationship with clients is fundamental to working in this way. Specialist

2018 Royal College of Nursing

158. People change lives: evaluation of Sistema Scotland’s Big Noise programme

The authors would like to express sincere gratitude to a range of individuals and partner organisations who have contributed greatly to this evaluation over the past five years. Thanks go to Dr Lisa Garnham (Glasgow Centre for Population Health, GCPH), Aileen Campbell (Audit Scotland), Linda Fenocchi, Dr Helen Mason, Professor Cam Donaldson (Glasgow Caledonian University), Patricia Watson and Simon Ross (Education Scotland) who have given of their time and energy to this work. Appreciation also goes (...) to Professor Carol Tannahill OBE (Director of the GCPH) for her unwavering support, guidance and encouragement from the outset of this evaluation. The authors also recognise the time and energy Sistema Scotland and Big Noise staff, as well as a range of delivery partner organisations, including the schools in each Big Noise locality, have given to this evaluation. Finally, gratitude goes to the children and young people who participate in Big Noise as well as their parents and guardians who have taken

2019 Glasgow Centre for Population Health

159. Transforming later lives – our strategy

across England by taking action on interconnected and enduring societal issues that will make the most difference. We are blessed to have secure funding that allows us to commit the next ten years to achieving the greatest possible impact on people’s lives. Our vision is a society where everyone enjoys their later life. By 2040, we want more people in later life to be in good health, financially secure, to have social connections and feel their lives are meaningful and purposeful. We know that people (...) homes defined as hazardous and half of all new homes will meet accessibility standards. Healthy ageing Why change is needed Our health as we age is fundamental to our quality of life, allowing us to remain independent, to work or be involved in our local community, to maintain social connections and family life and other things that give us meaning and purpose. Health is a main reason for leaving work early. There are great opportunities to support healthy ageing so that more people are able to keep

2018 The Centre for Ageing Better

160. Statins for the primary prevention of cardiovascular events

Remboursement des Médicament (Commission for the Reimbursement of Pharmaceuticals, Belgium) CUA Cost-Utility Analyses CVD Cardiovascular Disease DALY Disability-Adjusted Life Year DDD Defined Daily Dose EPS Echantillon Permanent – Permanente Steekproef (Permanent Sample, Belgium) ESC – EAS European Society of Cardiology – European Atherosclerosis Society GRADE Grading of Recommendations Assessment, Development and Evaluation working group HEED Health Economic Evaluations Database HMG-CoA 3-hydroxy-3-methyl (...) keep relevant information on several parameters in their medical records and specific indicators were chosen to allow for automatically monitoring the correct use of these guidelines through the Farmanet system that monitors all prescriptions obtained in public pharmacies in Belgium for a given patient. A first indicator monitors the high risk status of the patient population, namely the presence of diabetes and/or cardiovascular disorders by assessing concurrent medication use: antidiabetic drugs

2019 Belgian Health Care Knowledge Centre

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