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141. Our data-driven future in healthcare

of, their affiliated hospitals, universities, organisations or associations. Their participation should not be taken as endorsement by these bodies. The Academy is grateful to Understanding Patient Data for its ongoing support and input to this work. The Academy is also grateful for funding from a core grant from the Department for Business, Energy & Industrial Strategy to the Academy that was used to support this project. All web references were accessed in November 2018. This work is © the Academy of Medical (...) including provenance, accuracy, reliability and consistency over its life cycle. Data life cycle The different stages of the patient data journey. This involves various organisations and processes, including the generation and collection of data, curation, storage, access, use and its eventual destruction or legacy. Data processing The processing or curation of data to allow them to be used more effectively or linked with other datasets. Depersonalised data Data which have had any personal identifiers

2018 Academy of Medical Sciences

142. An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of PCOS in Adolescence

the interaction of genetic influences, non-heritable intra- and extrauterine environmental factors, and alternative adaptations to energy excess. However in the context of PCOS, puberty per se might play an important role in the molecular origins of IR and hyperinsulinemia. During puberty, adolescents experience a temporary decline in insulin sensitivity with a nadir in mid-puberty [ - ]. This was first described in an effort to understand the deterioration of glycemic control in type 1 diabetes during

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2019 Pediatric Endocrine Society

143. WHO Guidelines for the pharmacological and radiotherapeutic management of cancer pain in adults and adolescents

in Switzerland3 CONTENTS ACKNOWLEDGEMENTS 6 ABBREVIATIONS AND ACRONYMS 8 EXECUTIVE SUMMARY 9 Introduction 9 Aims of the guidelines . 9 Scope of the guidelines 9 Guidelines process and decision-making 10 RECOMMENDATIONS 11 1. INTRODUCTION 14 2. OBJECTIVES AND TARGET AUDIENCE OF THESE GUIDELINES 17 3. SCOPE OF THE GUIDELINES 18 4. METHODS USED IN THE GUIDELINES 19 5. CANCER PAIN MANAGEMENT – GUIDING PRINCIPLES 21 5.1. The goal of optimum management of pain is to reduce pain to levels which allow an acceptable (...) and 9.6 million deaths in 2018, significantly increas - ing the burden on patients, families, communities and the health system (1). Pain is experienced by 55% of patients undergoing anti-cancer treatment and by 66% of patients who have advanced, metastatic, or terminal disease (2). The goal of cancer pain management is to relieve pain to a level that allows for an acceptable quality of life. The World Health Organization (WHO) Guidelines for the pharmacologic and radiotherapeutic management of cancer

2019 World Health Organisation Guidelines

144. Incorporating Recognition and Management of Perinatal Depression Into Pediatric Practice

concluding: The consequences of allowing maternal depression to go underdiagnosed and untreated are detrimental to the health of all mothers and their children. Knowing a woman’s risk of developing depression peaks during her childbearing years, it is vital for all health care providers to recognize the symptoms of depression and understand the risk factors associated with maternal depression to identify and treat depression as soon as possible . In 2016, the US Preventive Services Task Force (USPSTF (...) (alterations in sleep, appetite, concentration, energy level, etc), as described in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) , occurring during pregnancy or after delivery. Although the diagnostic criteria for major depressive disorder (MDD) did not undergo significant change between the fourth edition and the DSM-5 , the specifier “with perinatal onset” replaced the traditional distinction between antenatal and postpartum onset. The reason for this change is that 50

2019 American Academy of Pediatrics

145. AACE/ACE Comprehensive Type 2 Diabetes Management Algorithm

to the new Endocrine Practice website. Click to access your account and reset your password if this is your first visit. TheIP ranges for your institution have already been added to your account. You maywish to review this information under the Institutional administration tab inyour User Profile. Not Yet Registered? Benefits of Registration Include: A Unique User Profile that will allow you to manage your current subscriptions (including online access) The ability to create favorites lists down (...) energy levels and well-being, and all patients should be advised to sleep on average approximately 7 hours per night. Evidence supports an association of 6 to 9 hours of sleep per night with a reduction in cardiometabolic risk factors, whereas sleep deprivation aggravates insulin resistance, hypertension, hyperglycemia, and dyslipidemia and increases inflammatory cytokines ( ). Daytime drowsiness, a frequent symptom of sleep disorders such as sleep apnea, is associated with increased risk

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2019 American Association of Clinical Endocrinologists

146. Developing a Value Framework for Genetic Diagnosis: Part I A Systematic Review of Outcomes Hierarchies and Measurement Approaches

research. ? One component of QI, professional development (education), was not addressed in this review. ? Available resources did not allow the scope of the review to include the wide range of specific outcomes of genetic diagnoses reported in publications of primary studies. Finally, this review described work in progress, as the concepts of quality, quality improvement and value continue to evolve. ACMG Value Review, March 16, 2012 Page 14 METHODS This report presents a “qualitative systematic (...) standardized approach of the quantitative systematic evidence reviews (SERs) with which many of us are more familiar, methods for QSR can be somewhat less well defined (or even controversial). Consequently, transparency was important. Like SERs, QSR methods included developing a review framework and key questions, as well as a plan for data collection and analysis. As with all reviews, clear exposition of methods was important to allow the reader to judge if the interpretation and conclusions were

2019 American College of Medical Genetics and Genomics

147. Global Vascular Guidelines for patients with chronic limb-threatening ischemia

Requirements by Role The Co-Editors of the Global Vascular Guidelines should have less than $10,000 USD in industry income in aggregate during their work on the guidelines or subsequent revisions. The majority (>50%) of the steering committee members and guideline authors should have less than $10,000 USD in industry income in aggregate during their work on the guidelines or subsequent revisions. The minority of steering committee members and authors allowed additional industry income may have no more than (...) , what is lacking is a uniform definition of clinical stages of disease and key patient-focused outcomes, contributing to an incomplete picture of the epidemiology of CLTI and a limited evidence base to guide daily practice. At the same time, rapidly evolving technologies in diagnostics, devices, drugs, and biologics offer new opportunities to improve treatment and to address unmet needs in this vulnerable population. A PubMed search of the term “critical limb ischemia” revealed >5000 citations

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2019 Society for Vascular Surgery

148. WHO consolidated guideline on self-care interventions for health: sexual and reproductive health and rights

that there will need to be meaningful engagement of affected communities. UPDATING OF THE GUIDELINE The concept for the format of this guideline is a “living guideline”. In a fast-moving field, this approach will allow for continual review of new evidence to inform further versions of the “living” document. The recommendations presented in this publication represent a subset of prioritized self- care interventions for SRHR, and this guideline aims to gradually include a broader set of self-care interventions over

2019 World Health Organisation Guidelines

149. Benign Prostatic Hyperplasia: Surgical Management of Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms

of substances with diuretic properties) or pharmacological management are either inadequate or inappropriate, warranting consideration of one of the many invasive procedures available for the treatment of LUTS attributed to BPH. Indications for the use of one of these modalities may include a desire by the patient to avoid taking a daily medication, failure of medical therapy to sufficiently ameliorate bothersome LUTS, and certain conditions that require more aggressive intervention where medical therapy (...) should be provided with the risk/benefit profile for all treatment options in light of their circumstances to allow them to make informed decisions regarding their treatment plans. Evaluation and Preoperative Testing Guideline Statement 1 1. Clinicians should take a medical history and utilize the AUA-Symptom Index (AUA-SI) and urinalysis in the initial evaluation of patients presenting with bothersome LUTS possibly attributed to BPH; select patients may also require post-void residual (PVR

2019 American Urological Association

151. Male Sexual Dysfunction

on erectile function recovery following bilateral nerve-sparing radical prostatectomy: a randomised placebo-controlled study (REACTT). Eur Urol, 2014. 65: 587. 129. Moncada, I., et al. Effects of tadalafil once daily or on demand versus placebo on time to recovery of erectile function in patients after bilateral nerve-sparing radical prostatectomy. World J Urol, 2015. 33(7)1031. 130. Patel, H.R., et al. Effects of tadalafil treatment after bilateral nerve-sparing radical prostatectomy: quality of life (...) prostatectomy. J Urol, 2013. 189: 2229. 133. Corona, G., et al. The safety and efficacy of Avanafil, a new 2nd generation PDE5i: Comprehensive review and meta-analysis. Expert Opin Drug Saf, 2016. 15(2)237. 134. Cui, H., et al. Efficacy and safety of long-term tadalafil 5 mg once daily combined with sildenafil 50 mg as needed at the early stage of treatment for patients with erectile dysfunction. Andrologia, 2015. 47(1)20. 135. Montorsi, F., et al. Recovery of spontaneous erectile function after

2019 European Association of Urology

152. Management of Non-neurogenic Male LUTS

symptoms of bladder outlet obstruction treated with watchful waiting for four years. Urology, 2004. 64: 1144. 61. McConnell, J.D., et al. The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. N Engl J Med, 2003. 349: 2387. 62. Roehrborn, C.G. Alfuzosin 10 mg once daily prevents overall clinical progression of benign prostatic hyperplasia but not acute urinary retention: results of a 2-year placebo-controlled study. BJU Int (...) daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: analysis of data pooled from 4 pivotal, double-blind, placebo controlled studies. J Urol, 2015. 193: 1581. 199. Donatucci, C.F., et al. Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a 1-year, open-label extension study. BJU Int, 2011. 107: 1110. 200. Porst, H., et al. Efficacy and safety of tadalafil 5 mg once daily for lower urinary tract symptoms

2019 European Association of Urology

153. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease

% higher mortality rate. Overall, plant protein was associated with a reduction in mortality rate of 10% for every 3% energy increment replacement of animal protein. 4. Intake of several food products has been shown to be potentially harmful or increase risk of ASCVD. Sugar-sweetened and artificially sweetened beverages have been correlated with increasing the development of T2DM and with ASCVD risk, with a 20% increase in the frequency of diabetes mellitus with 1 daily serving of these sweetened (...) recommendations.) Each topic area was assigned a primary writer, as well as a primary, and sometimes secondary, reviewer. These assignments were based on areas of particular expertise of writing committee members. All recommendations were fully reviewed and discussed among the full committee to allow for diverse perspectives and considerations for this guideline. Recommendations were then voted upon, with a modified Delphi process used to reach consensus. 1.2. Organization of the Writing Committee The writing

2019 American Heart Association

155. Male Hypogonadism

2% on Testosterone Concentration, Sex Drive and Energy in Hypogonadal Men: Results of a Placebo Controlled Study. J Urol, 2016. 195: 699. 114. Hackett, G., et al. Testosterone replacement therapy with long-acting testosterone undecanoate improves sexual function and quality-of-life parameters vs. placebo in a population of men with type 2 diabetes. J Sex Med, 2013. 10: 1612. 115. Corona, G., et al. Meta-analysis of Results of Testosterone Therapy on Sexual Function Based on International Index (...) of Erectile Function Scores. Eur Urol, 2017. 20: 20. 116. Cunningham, G.R., et al. Testosterone treatment and sexual function in older men with low testosterone levels. J Clin Endocrinol and Metab, 2016. 101: 3096. 117. Corona G, et al. Testosterone supplementation and sexual function: A meta-analysis study. J Sex Med, 2014. 11: 1577. 118. Mulhall J. P, et al. Impact of Baseline Total Testosterone Level on Successful Treatment of Sexual Dysfunction in Men Taking Once-Daily Tadalafil 5 mg for Lower Urinary

2019 European Association of Urology

157. Telehealth for Acute and Chronic Care Consultations

where, in terms of settings and clinical indications, telehealth is likely to improve access, quality, and efficiency. One approach is to assess the evidence about the different roles telehealth can play in healthcare. Telehealth for consultations allows medical expertise to be available where and when it is needed, minimizing potential time or geographic barriers to care and maximizing the efficient use of scarce resources. Telehealth for consultations has been studied across a range of clinical

2019 Effective Health Care Program (AHRQ)

158. Older people in care homes: Sex, Sexuality and Intimate Relationships

or disability, general tiredness, weakness or malaise leading to reduced energy available for self-care or social activities • common health problems – such as constipation, bladder weakness or chronic pain which can affect every day functioning and intimate relationships • loss of independence, reliance on others for help leading to lack of privacy in everyday surroundings • the personal impact of moving into a care home, leaving one’s home and the security of familiar surroundings and treasured (...) specialist help and health care services when appropriate. III Specific suggestions This level of working encompasses working with the client group and having a general understanding of the impact of illness or disability on their daily lives, but also a specific knowledge of sexual wellbeing, sexual health and OLDER PEOPLE IN CARE HOMES: SEX, SEXUALITY AND INTIMATE RELATIONSHIPS 12 sexual functioning. Establishing a therapeutic relationship with clients is fundamental to working in this way. Specialist

2018 Royal College of Nursing

159. Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies

modified by the Acute Kidney Injury Network. The 2012 Kidney Disease: Improving Global Outcomes guideline on the evaluation and management of AKI harmonized these 2 sets of criteria to allow early AKI detection, to permit epidemiological comparisons, and to standardize entry criteria and end points in clinical trials. The standardized criteria for the diagnosis of AKI greatly improved the sensitivity of detection of AKI with emphasis on small fluctuations in serum creatinine and urine output; however (...) of CKD, with subtle alterations in cardiac structure occurring even before a clinically significant decline in renal function. Speckle echocardiography with strain analysis allows a more detailed analysis of myocardial systolic function in the setting of normal LVEF and may have additive value over echocardiographic assessment of EF, including in uremic cardiomyopathy (type 4 CRS). In a study of 40 control subjects and 90 patients with CKD across a range of eGFR, LV longitudinal systolic strain

2019 American Heart Association

160. Primary Prevention of Cardiovascular Disease

with a reduction in mortality rate of 10% for every 3% energy increment replacement of animal protein. 4. Intake of several food products has been shown to be potentially harmful or increase risk of ASCVD. Sugar-sweetened and artificially sweetened beverages have been correlated with increasing the development of T2DM and with ASCVD risk, with a 20% increase in the frequency of diabetes mellitus with 1 daily serving of these sweetened beverages (S3.1-18). In large cohort studies, consumption of added sugar (...) Table S1 in the Web Supplement for a list of relevant publications and statements used in support of the guideline’s recommendations.) Each topic area was assigned a primary writer, as well as a primary, and sometimes secondary, reviewer. These assignments were based on areas of particular expertise of writing committee members. All recommendations were fully reviewed and discussed among the full committee to allow for diverse perspectives and considerations for this guideline. Recommendations were

2019 American College of Cardiology

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