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Daily Energy Allowance

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101. Transarterial radioembolisation with yttrium-90 (TARE-Y) for the treatment of unresectable hepatocellular carcinoma

this to be inappropriate as TACE is still used in practice. MSAC acknowledged that, for patients with advanced HCC, there is currently no alternative to sorafenib, a medicine that has major side effects. MSAC noted that TARE-Y is a one-off treatment (compared with daily doses of sorafenib). MSAC also noted that TARE-Y is the only treatment option when first-line TACE is contraindicated or fails, and when the patient is intolerant to second-line treatment with sorafenib (e.g. due adverse events relating to the skin (...) with advanced HCC; however, this is based on only one RCT (the SARAH trial). MSAC noted the substantially different adverse event profiles of TARE-Y and sorafenib. Adverse events for TARE-Y include one-off events such as REILD (radioembolisation-induced liver disease) and lung toxicity, whereas adverse events for sorafenib include daily systemic effects. MSAC noted that available evidence shows TARE-Y to be inferior to BSC in terms of safety in patients with intermediate or advanced unresectable HCC

2019 Medical Services Advisory Committee

102. Organizational Guideline for the Delivery of Stereotactic Radiosurgery for Brain Metastasis in Ontario

the patient during treatment o Delivering accurate SRS treatment after appropriate approvals o Patient care and side effect management o Organizing daily workflow of patients and staff o Performing daily QA and ensuring safe operation of the technology unit o Performing emergency procedures adhering to protocols if necessary Guideline 21-4 Section 1: Recommendations – August 27, 2019 Page 4 Medical Dosimetrist ? Qualifications: o MRT(T) graduate of a recognized radiation therapy program with registration (...) patient positioning/immobilization o Performing and assessing pre-treatment imaging for treatment verification Guideline 21-4 Section 2: Guideline - August 27, 2019 Page 11 o Monitoring the patient during treatment o Delivering accurate SRS treatment after appropriate approvals o Patient care and side effect management o Organizing daily workflow of patients and staff o Performing daily QA and ensuring safe operation of the technology unit o Performing emergency procedures adhering to protocols

2019 Cancer Care Ontario

103. Reducing costs in hospitals

, with the goal of reducing daily artificial variation to make bed occupancy more predictable. To do this, staff analysed patient-flow dynamics, evaluating surgical providers’ predicted need for intensive care and predicted length of stay (LOS). When a procedure was scheduled, surgical providers made initial LOS estimates on the basis of personal experience, the complexity of the case, patient co-morbidities, best-practice plans, and historical data. The electronic surgical scheduling system was revised so (...) that the operative case and an ICU bed (if needed postoperatively) were scheduled (reserved) at the same time. The surgeon estimated a projected LOS when the case was initially scheduled. Reserved beds were continuously monitored, and the computerised scheduling system restricted operative-case scheduling if a bed was needed and the elective case limit for that day had been reached. An admission control model was used to limit the maximum allowable elective surgical cases requiring ICU access per day

2019 Monash Health Evidence Reviews

104. Energy Dense Formula to People Living in Old Peoples Home

i.e. at 8.00, 12.00 and 20.00. Other Name: Nutricia PDS:1005912 Outcome Measures Go to Primary Outcome Measures : Increased intake of energy and nutrients [ Time Frame: 6 weeks as intervention 6 weeks as control ] The sample size has been estimated upon a minimum difference in daily energy intake between the Control and Calogen group of 200 kcal (4). To detect a significant difference in energy intake at the 5% significance level and with 80% power 27 subjects in each group were needed. To allow (...) on energy intake, fatty acid profile and constipation. The investigators have recently performed a clinical trial in geriatric patients in an acute-ward setting to evaluate the effects of a similar fat emulsion, Calogen, without micronutrients. The investigators could conclude that this fat emulsion based on MUFA and PUFA distributed three times daily at medication rounds may have positive effects on weight, appetite and serum lipids. Moreover the approach was well accepted by patients and nurses

2010 Clinical Trials

105. Intranasal delivery of mouse [D-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, improves energy balance, glycaemic control, insulin sensitivity and bone formation in leptin-resistant C57BLK/6-m db/db mice. (PubMed)

examined the effects of intranasal delivery of mouse [D-Leu-4]-OB3 in Intravail(®) on energy balance, glucose regulation, insulin secretion and serum levels of osteocalcin, a specific and sensitive marker of bone formation. Genetically obese C57BLK/6-m db/db mice were allowed food and water ad libitum and given either Intravail(®) alone or mouse [D-Leu-4]-OB3 in Intravail(®) for 14 days by intranasal instillation.Mouse [D-Leu-4]-OB3 reduced body weight gain, daily food intake, daily water intake (...) Intranasal delivery of mouse [D-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, improves energy balance, glycaemic control, insulin sensitivity and bone formation in leptin-resistant C57BLK/6-m db/db mice. We have recently shown that intranasal administration of mouse [D-Leu-4]-OB3 reconstituted in Intravail(®) to male Swiss Webster mice resulted in significantly higher uptake and bioavailability when compared with commonly used injection methods of delivery.In this study, we

2010 obesity & metabolism

106. Comparison of the Cosmed K4b(2) portable metabolic system in measuring steady-state walking energy expenditure. (PubMed)

Comparison of the Cosmed K4b(2) portable metabolic system in measuring steady-state walking energy expenditure. Recent introduction of the Cosmed K4b(2) portable metabolic analyzer allows measurement of oxygen consumption outside of a laboratory setting in more typical clinical or household environments and thus may be used to obtain information on the metabolic costs of specific daily life activities. The purpose of this study was to assess the accuracy of the Cosmed K4b(2) portable metabolic

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2010 PloS one Controlled trial quality: uncertain

107. Changes in body fat percentage during body weight stable conditions of increased daily protein intake vs. control. (PubMed)

group (n=12) and an isoenergetic combination of carbohydrate and fat supplements in the control group (n=12). Daily protein intake was calculated from a 24h urinary nitrogen. Body composition was measured by a combination of underwater-weighing technique, deuterium-dilution technique and whole-body dual-energy X-ray absorptiometry (DXA), a method that allows for estimation of 4-body compartments (fat and lean; water, bone and rest).Subjects were weight stable and did not change their habitual (...) Changes in body fat percentage during body weight stable conditions of increased daily protein intake vs. control. The objective of this study was to examine if increased protein intake vs. control influences body fat percentage during stable body weight.Body composition was assessed before and after a 3-month isoenergetic dietary intervention of 2MJ/d supplements exchanged with 2MJ/d of habitual ad libitum energy intake. The parallel design consisted of protein-rich supplements in the protein

2010 Physiology & behavior Controlled trial quality: uncertain

108. Public health service provision by community pharmacies: a systematic map of evidence

of contact with a healthcare professional (PSNC 2013). The role of the community pharmacist has changed substantially over recent years, and they are now considered an important part of the structural landscape of our health services. CPs usually offer convenient opening times, including evening and weekends, allowing access for people who work a range of hours. They are often well placed, geographically, to access groups that services are not otherwise reaching (LGA 2014; PSNC 2013). It has been shown

2019 EPPI Centre

109. Risk Factors for Endometrial Cancer - A review of the evidence

organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and retain this copyright notice and all disclaimer notices as part of that reproduction. Apart from rights to use as permitted by the Copyright Act 1968 or allowed by this copyright notice, all other rights are reserved and you are not allowed to reproduce the whole or any part of this work in any way (electronic or otherwise) without first being given the specific written permission from Cancer (...) Bibliographic searches were performed on the Cochrane Library and Medline via OVID using MeSH terms and free text words: Endometrial cancer risk factors: a review of the evidence 12 Search date 8 January 2018 Ovid MEDLINE(R) Epub Ahead of Print, In –Process & Other Non –Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R) 1946 to Present (maligna$ or cancer$ or carcinoma or tumo?r).ti,ab. (endomet$ or corpus uteri or uterine or uterus).ti,ab. (risk or prognos$ or predict$ or inciden$ or associate

2019 Cancer Australia

110. Qualitative evidence on barriers to and facilitators of women’s participation in higher or growing productivity and male-dominated labour market sectors in low- and middle-income countries

Following a comprehensive search strategy, of the 216 studies that appeared possibly relevant from their titles and abstracts, on further inspection of the full reports, 37 provided no detail on labour market outcomes in high growth or male dominated sectors. Those that did focused on commercial agriculture (49%), trade (31%), business administration services (17%), energy including mining (16%), accommodation and food (11%), finance (6%), and transportation (3%). Other studies were unable to contribute (...) to answering the review question because they did not address low or lower-middle income countries (38), and or were not qualitative studies (101) and therefore were unable to provide explanations about barriers or facilitators. A further 22 were excluded because they were not of high nor medium quality. This allowed the synthesis effort to be focused on the 18 studies that both fell within the review’s scope and used research methods with high or medium rigour to elicit participants’ experiences. The 18

2019 EPPI Centre

112. Statins for the primary prevention of cardiovascular events

Remboursement des Médicament (Commission for the Reimbursement of Pharmaceuticals, Belgium) CUA Cost-Utility Analyses CVD Cardiovascular Disease DALY Disability-Adjusted Life Year DDD Defined Daily Dose EPS Echantillon Permanent – Permanente Steekproef (Permanent Sample, Belgium) ESC – EAS European Society of Cardiology – European Atherosclerosis Society GRADE Grading of Recommendations Assessment, Development and Evaluation working group HEED Health Economic Evaluations Database HMG-CoA 3-hydroxy-3-methyl (...) keep relevant information on several parameters in their medical records and specific indicators were chosen to allow for automatically monitoring the correct use of these guidelines through the Farmanet system that monitors all prescriptions obtained in public pharmacies in Belgium for a given patient. A first indicator monitors the high risk status of the patient population, namely the presence of diabetes and/or cardiovascular disorders by assessing concurrent medication use: antidiabetic drugs

2019 Belgian Health Care Knowledge Centre

113. Bariatric surgery: an HTA report on the efficacy, safety and cost-effectiveness

-term survival benefit after bariatric surgery. However, such studies are prone to bias (e.g. possible selection of healthier or more motivated patients) and do not allow to make firm conclusions. The evaluation of the effect of MBS on long-term mortality, is based on systemic review and meta-analyses of studies that are essentially of observational nature. They are complemented with some other data from recently published registry based cohort-studies. The data from these sources show in general

2019 Belgian Health Care Knowledge Centre

114. Home mechanical ventilation for patients with Amyotrophic Lateral Sclerosis: A CTS Clinical Practice Guideline

survival advantage with NIV compared to controls: 216 (range 94–681) days vs. 11 (1–283) days. There were six deaths of nine patients in the control group with better bulbar function within two weeks of enrollment. Five of the six had severe respiratory muscle weakness at enrollment. The “poor” bulbar function group showed improvement in health-related quality of life (HRQoL) if receiving NIV, but no survival benefit: 222 (range 75–1382) days vs 261 (6–878) days. The mean duration of daily use (...) HRQoL, 21,23,30–33 authors consistently reported improvements in HRQoL in cer- tain domains for patients using NIV. These included sustained improvements in mental health, energy/vitality, social isola- tion, fatigue and mastery. Physical function domains generally worsened as would be expected with disease progression. Gas exchange and pulmonary function All studies reporting gas exchange after initiation of NIV 31,32,34–36 show reduction of daytime partial pressure of carbondioxide(pCO2

2019 Canadian Thoracic Society

115. People change lives: evaluation of Sistema Scotland’s Big Noise programme

The authors would like to express sincere gratitude to a range of individuals and partner organisations who have contributed greatly to this evaluation over the past five years. Thanks go to Dr Lisa Garnham (Glasgow Centre for Population Health, GCPH), Aileen Campbell (Audit Scotland), Linda Fenocchi, Dr Helen Mason, Professor Cam Donaldson (Glasgow Caledonian University), Patricia Watson and Simon Ross (Education Scotland) who have given of their time and energy to this work. Appreciation also goes (...) to Professor Carol Tannahill OBE (Director of the GCPH) for her unwavering support, guidance and encouragement from the outset of this evaluation. The authors also recognise the time and energy Sistema Scotland and Big Noise staff, as well as a range of delivery partner organisations, including the schools in each Big Noise locality, have given to this evaluation. Finally, gratitude goes to the children and young people who participate in Big Noise as well as their parents and guardians who have taken

2019 Glasgow Centre for Population Health

116. Integrating money advice workers into primary care settings: an evaluation

on to other support services. The nine practices achieved the equivalent of more than half of the 1,264 referrals achieved under the ‘locality model’, over a similar 12 month period. The established locality model allows healthcare professionals to refer people to advice services based in seven health centres across northeast Glasgow. There were 71 locality referrals from 35 GP practices over this period, in sharp contrast to 654 from the nine practices testing this integrated approach. Demand for advice (...) , such as having access to medical evidence and drafting letters signed off by the GP to be used at benefits reviews and appeals. The workers viewed practices as a ‘trusted hub’ that could help reduce stigma and encourage people to be more open about their money worries. The project benefits included some practice staff reporting an easing of workload and reduction in welfare-related appointments, new working relationships that allowed staff to directly refer to advice workers, and a subsequent increase in GPs

2019 Glasgow Centre for Population Health

117. Stepping Stones for Families’ Family Wellbeing Service: evaluation

of the parents interviewed talked about feeling socially isolated, with nursery and SSfF staff also very aware of this as an issue. It was striking that these feelings of social isolation were present in parents with partners as well as those without. Feelings of isolation were felt to have been triggered by a range of different circumstances. Parents reported that they had lost friends when they became mothers, with their time and energy focused on their children, leaving them neither energy nor opportunity (...) parents to apply for grants from charitable trusts, for example to provide a new carpet, or a new freezer without which a parent was doing expensive daily shops. ? Helping parents access a mobility car and accompanying them on a couple of drives to give them the confidence to use it. ? Helping asylum seeking families access their bus passes. ? Accompanying parents with health problems to reviews of their employment situation. ? Pushing social landlords to resolve repairs to parents’ accommodation

2019 Glasgow Centre for Population Health

118. Low back pain and sciatica in over 16s: assessment and management

://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 15 of 18in the long term? Wh Why this is important y this is important Radiofrequency denervation is a minimally invasive and percutaneous procedure performed under local anaesthesia or light intravenous sedation. Radiofrequency energy is delivered along an insulated needle in contact with the target nerves. This focused electrical energy heats and denatures the nerve. This may allow axons to regenerate with time, requiring the repetition (...) and sciatica in their daily life. The guideline aims to improve people's quality of life by promoting the most effective forms of care for low back pain and sciatica. Who is it for? Healthcare professionals Commissioners and providers of healthcare People with low back pain or sciatica, and their families and carers Low back pain and sciatica in over 16s: assessment and management (NG59) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice

2016 National Institute for Health and Clinical Excellence - Clinical Guidelines

119. Motor neurone disease: assessment and management

is it for? 4 Recommendations 5 1.1 Recognition and referral 5 1.2 Information and support at diagnosis 6 1.3 Cognitive assessments 9 1.4 Prognostic factors 9 1.5 Organisation of care 9 1.6 Psychological and social care support 13 1.7 Planning for end of life 15 1.8 Managing symptoms 16 1.9 Equipment and adaptations to aid activities of daily living and mobility 18 1.10 Nutrition and gastrostomy 19 1.11 Communication 21 1.12 Respiratory function and respiratory symptoms 22 1.13 Cough effectiveness 23 1.14 (...) and activities of daily living (see section 1.9). Saliva problems, such as drooling of saliva (sialorrhoea) and thick, tenacious saliva (see recommendations 1.8.10–1.8.15 in section 1.8). Speech and communication (see section 1.11). Cough effectiveness (see section 1.13). Respiratory function, respiratory symptoms and non-invasive ventilation (see sections 1.12 and 1.14). Pain and other symptoms, such as constipation. Cognition and behaviour (see section 1.3). Psychological support needs (see recommendations

2016 National Institute for Health and Clinical Excellence - Clinical Guidelines

120. The Effectiveness and Risks of Cranial Electrical Stimulation

randomized controlled trials were included Population(s): Adult patients with one or more of the following conditions: a chronic pain condition, depression, anxiety, insomnia, and posttraumatic stress disorder (PTSD) Intervention(s): Any cranial electrical stimulation (CES) device used in the home setting Comparator(s): Usual care including appropriate known treatments Outcome(s): Chronic pain: pain severity, use of opioid analgesic medication, quality of life, and daily functioning; Depression (...) and anxiety: clinical assessments, scores on standardized Cranial Electrical Stimulation Evidence-based Synthesis Program 5 inventories; PTSD: symptom severity, quality-of-life measures, daily functioning; Insomnia: ability to initiate /maintain sleep, resolution of symptoms Timing: No restrictions Setting: Home setting, or office-based if needed for the conduct of the trial. Studies of hospitalized patients were excluded. DATA ABSTRACTION We abstracted data on the following: condition, description

2018 Veterans Affairs Evidence-based Synthesis Program Reports

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