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181. Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities

[OR] for 1% increase in BSA 1.020, 95% CI 1.012-1.029, P < .0005). A study of the prevalence of PsA in the United States in 2005 showed that 11% of psoriasis patients had PsA, with 39% indicating it caused a significant impact on activities of daily living. x 13 Gelfand, J.M., Gladman, D.D., Mease, P.J. et al. Epidemiology of psoriatic arthritis in the population of the United States. J Am Acad Dermatol . 2005 ; 53 : 573 Thus, after reviewing the body of evidence, the prevalence of PsA among psoriasis

2019 American Academy of Dermatology

183. UK guidelines on the management of iron deficiency in pregnancy

guidelines advise testing at the booking appointment and at 28 weeks [Pavord et al , ; Royal College of Obstetricians & Gynaecologists, ; White et al , ; National Institute for Health and Care Excellence (NICE) ]. New near‐patient test assays may allow more frequent testing in the future. Red cell indices A low Hb, mean cell volume (MCV), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC) are suggestive of iron deficiency, but need to be interpreted with caution in view (...) deficiency Dietary advice The average daily iron intake from food for women in Great Britain is 10 mg, of which 10–15% is absorbed. The capacity for absorption is enhanced in pregnancy but physiological iron requirements increase from 1–2 mg to 6 mg per day (Bothwell, ), with increasing demand as pregnancy advances. The recommended daily intake (RDA) of iron for the latter half of pregnancy is 27 mg, twice that of a non‐pregnant woman ( ). The amount of iron absorption depends upon the amount of iron

2019 British Committee for Standards in Haematology

184. Axicabtagene ciloleucel (Yescarta) - diffuse large B-cell lymphoma (DLBCL); primary mediastinal large B-cell lymphoma (PMBCL)

Axicabtagene ciloleucel (Yescarta) - diffuse large B-cell lymphoma (DLBCL); primary mediastinal large B-cell lymphoma (PMBCL) 1 ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS 2 This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. See section 4.8 for how to report adverse reactions. 1. NAME OF THE MEDICINAL PRODUCT YESCARTA 0.4 – 2 x 10 8 cells (...) and fludarabine 30 mg/m 2 intravenous should be administered on the 5th, 4th, and 3rd day before infusion of YESCARTA. Pre-medication • Paracetamol 500-1000 mg given orally and diphenhydramine 12.5 mg intravenous or oral (or equivalent) approximately 1 hour before YESCARTA infusion is recommended. • Prophylactic use of systemic steroids is not recommended as it may interfere with the activity of YESCARTA. Monitoring • Patients should be monitored daily for the first 10 days following infusion for signs

2018 European Medicines Agency - EPARs

185. Ertugliflozin l-pyroglutamic acid (Steglatro) - Diabetes Mellitus, Type 2

Attribute CTX serum c-terminal telopeptide sequence of Type 1 collagen CV cardiovascular CVOT cardiovascular outcome trial CYP cytochrome P450 DBP diastolic blood pressure DDI drug-drug interaction DOC Dissolved Oxygen Concentration DoE Design of experiments DT 50 Time required for 50% degradation/dissipation of the initial concentration DT 90 Time required for 90% degradation/dissipation of the initial concentration DXA dual-energy x-ray absorptiometry EASD European Association for the Study (...) Predicted environmental concentration in sediments PEC SW Predicted environmental concentration in surface waters P-gp P-glycoprotein Ph. Eur. European Pharmacopoeia PND postnatal day PNEC Predicted no-effect concentration PPG post-prandial glucose PTH parathyroid hormone PVC poly vinyl chloride PXRD powder X-Ray diffraction QbD quality by design QC quality control qd once daily QT time from the start of the Q wave to the end of the T wave QTc QT interval corrected QTcF QT interval corrected using

2018 European Medicines Agency - EPARs

186. Ertugliflozin l-pyroglutamic acid / metformin hydrochloride (Segluromet) - Diabetes Mellitus, Type 2

under the curve AUCinf area under the concentration-time curve from 0 to infinity AUClast area under the concentration –time curve from zero to time of last measurable concentration BCS biopharmaceutical classification system bid twice daily BMD bone mineral density BMI body mass index Broad pool pooled safety data from all seven ertugliflozin phase III studies BUN blood urea nitrogen CFU colony forming units CHMP Committee for Medicinal Products for Human use CI confidence interval cLDA constrained (...) /dissipation of the initial concentration DXA dual-energy x-ray absorptiometry E5 ertugliflozin 5 mg qd (Study P005/1019) E5/S100 ertugliflozin 5 mg qd + sitagliptin 100 mg qd (Study P005/1019) E15 ertugliflozin 15 mg qd (Study P005/1019) E15/S100 ertugliflozin 15 mg qd + sitagliptin 100 mg qd (Study P005/1019) ECHA European Chemicals Agency ECG Electrocardiogram eGFR estimated glomerular filtration rate ER approach excluding rescue treatment approach ERA Environmental risk assessment ertu ertugliflozin

2018 European Medicines Agency - EPARs

187. Ertugliflozin l-pyroglutamic acid / sitagliptin phosphate monohydrate (Steglujan) - Diabetes Mellitus, Type 2

of change PEC SED Predicted environmental concentration in sediments PEC SW Predicted environmental concentration in surface waters P-gp P-glycoprotein Ph. Eur. European Pharmacopoeia PK pharmacokinetic(s) PNEC Predicted no-effect concentration PPG post-prandial glucose PVC poly vinyl chloride PXRD powder X-Ray diffraction QbD quality by design QC quality control qd once daily QT time from the start of the Q wave to the end of the T wave QTc QT interval corrected QTPP quality target product profile RA (...) previously reviewed by the European Food Safety Authority (EFSA) where its use in supplements up to 3 grams per day was considered to be of no concern. (This amount is significantly higher than the 3.42 mg L-PGA present in the maximum daily dose (15 mg) of ertugliflozin.) CHMP agreed that L-PGA can be considered a reagent and not a starting material in line with ICH Q11 based on the fact that L-PGA is a commonly available commodity chemical used in several industries and it may be obtained from L

2018 European Medicines Agency - EPARs

188. Cardiac rehabilitation

and therapeutic effects on many chronic conditions including CHD. 38 The term ‘physical activity’ is defined as bodily movement which requires energy expenditure. 39 Exercise is a subcategory of physical activity that is planned, structured, repetitive, and aims to improve or maintain one or more components of physical fitness. 39 All individuals should be advised to minimise the amount of time they spend sedentary, especially over extended periods and should aim to be active daily. 8 This should be in line (...) , instruction and exercise monitoring) for older patients. There is a lack of high-quality trials on improving CR uptake amongst hard to reach, or under-represented groups, such as older women or people from ethnic minorities. 15 3.2.2 MAINTAINING ENGAGEMENT Results from trials of strategies to increase adherence to CR programmes are mixed. 14 Eight trials of low quality were identified. The interventions reported to be of benefit were: y goal setting y action planning y using activity monitoring with daily

2017 SIGN

189. Standards for post-concussion care from diagnosis to the interdisciplinary concussion clinic

individual experts are able to function with a sense of awareness of one another as well as an awareness of the various structures and resources in the system that either support them to work together or inhibit them from working together. 17 Concussion: Concussion denotes the acute neurophysiological event related to blunt impact or other mechanical energy applied to the head, such as from sudden acceleration, deceleration or rotational forces. All concussions are mild traumatic brain injuries (...) , the pathway should be adhered to, as diagnosis is the first in many steps of an appropriate care flow. It is important for patients to understand how to manage their activities post-concussion, while not inundating or overstimulating them with too much detail in the initial few days. Education is best provided in multiple formats, to allow patients to learn in the medium they can tolerate and are comfortable with, while providing clear sources for more information, as wanted or needed. The majority

2017 CPG Infobase

190. Gynaecological Cancers: a Handbook for Aboriginal and Torres Strait Islander Health Workers and Health Practitioners

are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and retain this copyright notice and all disclaimer notices as part of that reproduction. Apart from rights to use as permitted by the Copyright Act 1968 or allowed by this copyright notice, all other rights are reserved and you are not allowed to reproduce the whole or any part of this work in any way (electronic or otherwise) without first (...) , but only if you or your organisation do not use the reproduction for any commercial purpose and retain this copyright notice and all disclaimer notices as part of that reproduction. Apart from these rights to use as permitted by the Copyright Act 1968 or allowed by this copyright notice, all other rights are reserved and you are not allowed to reproduce the whole or any part of this work in any way (electronic or otherwise) without first being given the specific written permission from Cancer Australia

2018 Cancer Australia

191. Risk factors for breast cancer: A review of the evidence 2018

your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and retain this copyright notice and all disclaimer notices as part of that reproduction. Apart from rights to use as permitted by the Copyright Act 1968 or allowed by this copyright notice, all other rights are reserved and you are not allowed to reproduce the whole or any part of this work in any way (electronic or otherwise) without first being given the specific written permission from (...) 4.7.12 Diet—foods high in carotenoids 108 4.7.13 Diet—Mediterranean diet 110 4.7.14 Diet—phytoestrogens 112 Breast cancer risk factors: A review of the evidence iv 4.7.15 Diet—glycaemic index 114 4.7.16 Diet—total energy 115 4.7.17 Diet—sugar 117 4.7.18 Diet—fat 118 4.7.19 Diet—processed meat 119 4.7.20 Diet—red meat 121 4.7.21 Environmental tobacco smoke 123 4.7.22 Tobacco smoking 125 4.7.23 Physical activity 127 4.7.24 Shift work disrupting circadian rhythm 130 4.8 Medical factors 133 4.8.1 Aspirin

2018 Cancer Australia

192. Screen-based activities and children and young people’s mental health and psychosocial wellbeing: a systematic map of reviews

television while ‘joining the discussion’ online or playing web-based multiplayer video games, which allow CYP to interact with others across the world, while simultaneously listening to video blogs online which discuss the game. Similarly, social media platforms not only enable users to generate their own content but also to share content across platforms (e.g. by linking ‘stories’ on Snapchat to Instagram to Facebook), enabling communication in real time to broader and larger audiences. In 2016

2018 EPPI Centre

193. The future of public health research

Science’s report on ‘The health of people’, which explores how the social sciences can improve the health of the public. 4 She noted that much of the contribution that the social sciences can make to this endeavour remains untapped. The report aimed to demonstrate this contribution, and to help change environments, policies, practices and behaviours to prevent ill health, allow patients to manage conditions, and stimulate the delivery of high-quality care. Professor Michie articulated the report’s key (...) to the NHS of the medicalisation of mental health conditions. Productive workforce and sustainable economy A healthy workforce is essential for the economy, and being healthy during working ages is essential to allow individuals and their families to reach their full potential. Attendees suggested productivity, and the health of people of working age, should be framed as a public health challenge. They argued that this could be a powerful way of rebranding public health, given the current focus

2017 Academy of Medical Sciences

194. Frailty in Older Adults - Early Identification and Management

patient fitness for physical activity (fall risk, cardiac risk, etc.). Consider referral to a community exercise program. A program that includes balance, strength, flexibility and endurance training is recommended. Direct patient to physical activity services offered by or 8-1-1. Consider referral to physical therapist or occupational therapist. Activity level Exercise program Fatigue and energy level Endurance and strength Basic Activities of Daily Living Consider referral for occupational therapy (...) and strength, reduced energy and exercise tolerance, cognitive impairment, and decreased physiological reserve, leading to poor health outcomes and a reduced ability to recover from acute stress. 6 Overall, frailty exists on a spectrum. 7 While frailty is often chronic and progressive, it is also dynamic and some patients may be able to improve their frail status. 8 Risk Factors With aging, there is a gradual decline in physiological reserve. However, aging is a complex process; evaluation of frailty

2017 Clinical Practice Guidelines and Protocols in British Columbia

195. GCPH response - a healthier future

in both children and adults. Commentators have described this ‘obesogenic environment’ as a major factor in the growth of obesity 9 . Examples of this obesogenic environment include the heavy promotion and availability of fast food, energy- dense snacks, and high sugar drinks which are particularly targeted at children; low cost and large portion sizes of foods; limited access to and affordability of healthy food; and urban design, including the transport system, that inhibits daily physical activity (...) of high fat, sugar and/or salt products on public transport vehicles and in public transport stations. We also suggest that the extent to which currently devolved powers allow for restrictions to sponsorship of events by brands/companies promoting food products high in fat, salt and/or sugar is explored. We would support a code of practice for public authorities in Scotland to avoid sponsorship from/advertising of brands or companies promoting foods or drinks high in fat, sugar and/or salt. 4 Question

2018 Glasgow Centre for Population Health

196. Appropriate care at the end of life

and the efforts of health care providers to reduce one’s pain during the final phase of life, just aiming for improved quality of the remaining life and the highest comfort possible. Nevertheless, because death is inevitably connected with daily life, society must find a way to provide as much appropriate care as possible, and avoid inappropriate care, for all of its citizens, thereby respecting the possibilities of health care and the wishes of all that are involved (patients, health care professionals (...) to the second part of the questionnaire. Depending on the answers provided, this part contained questions about KCE Report 296 Appropriate care at the end of life 15 experiences with inappropriate care, with appropriate care, or both, allowing us to collect the respondents’ narrative(s). Afterwards, in the third part of the questionnaire, all respondents’ attitudes towards end of life care were measured, and their opinions on the subject were further questioned. More specifically, several statements were

2018 Belgian Health Care Knowledge Centre

198. How to improve the Organisation of Mental healthcare for older adults in Belgium?

at least one lump sum for nursing care at home 159 10 How to improve the Organisation of Mental healthcare for older adults in Belgium? KCE Report 301 LIST OF ABBREVIATIONS ABBREVIATION DEFINITION A bed Neuropsychiatric bed for observation and treatment A1 bed Neuropsychiatric bed for observation and treatment (day-bed) A2 bed Neuropsychiatric bed for observation and treatment night-bed) ACTE Assertive Community Treatment for the Elderly ADL Activities of Daily Living ALC Alternate Level of Care APA (...) health user in society (desinstutionalisation). ? Readaptation and rehabilitation in the frame of an essential collaboration with and between other sectors of the social welfare system (e.g. education, social housing, etc.) to the rehabilitation process of persons with mental healthcare problems in order to allow them to participate in the society (inclusion). ? Enhance the collaboration with and between adult healthcare, mental health services, services for people with disabilities and around

2018 Belgian Health Care Knowledge Centre

199. Management of Acute Myocardial Infarction in patients presenting with ST-segment elevation

the best management strategies for an individual patient with a given condition. Guidelines and their recommendations should facilitate decision making of health professionals in their daily practice. However, the final decisions concerning an individual patient must be made by the responsible health professional(s) in consultation with the patient and caregiver as appropriate. A great number of guidelines have been issued in recent years by the European Society of Cardiology (ESC), as well as by other (...) of disease may be favourably influenced by the thorough application of clinical recommendations. Surveys and registries are needed to verify that real-life daily practice is in keeping with what is recommended in the guidelines, thus completing the loop between clinical research, writing of guidelines, disseminating them and implementing them into clinical practice. Health professionals are encouraged to take the ESC Guidelines fully into account when exercising their clinical judgment, as well

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2017 European Society of Cardiology

200. Effectiveness and Harms of Spinal Manipulative Therapy for the Treatment of Acute Neck and Lower Back Pain

, and in studies of better methodological quality. The 3 studies that reported the largest beneficial effects for SMT all selected patients based on specific criteria. Other Outcomes Too few studies included outcomes other than pain and function to allow us to draw conclusions. Four studies reported return-to-work or duration of sick leave (2 of which reported no differences between groups and one each reported shorter and longer sick leave for the SMT group), one study reported no differences in SF-12

2017 Veterans Affairs Evidence-based Synthesis Program Reports

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