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DOT Examination

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1. DOT Examination

DOT Examination DOT Examination Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 DOT Examination DOT Examination Aka: DOT Examination (...) Disqualification per physician assessment Examples Musculoskeletal, neurologic or vascular disease (typically disqualifying with or without medication) Psychiatric illness Judgment or reality perception affected Reaction time affected Psychotropic medications altering consciousness Consciousness altering substance use (disqualifying in most cases) Schedule I Drug (e.g. , ) Current Consider counselor assessment IV. Resources Federal Motor Safety Administration DOT Rules and regulations Medical Examiner Handbook

2018 FP Notebook

2. Benign yellow dot maculopathy (PubMed)

Benign yellow dot maculopathy To describe a new family with benign yellow dot maculopathy.A young male patient was found to have bilateral multiple small yellow dots in both maculae. Visual acuity and color vision were normal, and no pathological findings were demonstrated on automated visual field, optical coherence tomography (OCT) and electrophysiological testing. Examination of his parents revealed similar findings in his mother, suggesting autosomal dominant inheritance. No deterioration (...) of vision occurred over long term follow up. These findings are consistent with the newly described phenotype of benign yellow dot maculopathy.This is the first report of patients with benign yellow dot maculopathy since its original description, and the first to document it in a family of North African descent. This report will serve to raise awareness to this phenotype, which may be more common than currently known.

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2018 American journal of ophthalmology case reports

3. A failure to show the efficacy of a dot-probe attentional training in dysphoria: Evidence from an eye-tracking study. (PubMed)

A failure to show the efficacy of a dot-probe attentional training in dysphoria: Evidence from an eye-tracking study. This study examines whether a 4-day dot-probe attentional training to orient attention toward positive words could lead participants with dysphoria to change selective attention to emotional faces. It was also explored whether this positive attentional bias training could lead to a decrease in depressive symptoms.Participants were randomly assigned to Positive Training Group (...) (PTG) and No Training Group (NTG). PTG was composed of 16 subjects, whereas NTG was composed of 15 subjects. All participants were women with a mean age of 22.87 (SD = 3.21).Results showed that dysphoric participants in the PTG did not show changes in attentional patterns to emotional faces. Furthermore, depressive symptoms did not significantly change after the 4-session training.These results suggest that cognitive training procedures based on dot-probe paradigms are probably not adequate

2018 Journal of clinical psychology

4. Face-Inversion Effect on Disgust Evoked by a Cluster of Dots (PubMed)

Face-Inversion Effect on Disgust Evoked by a Cluster of Dots A cluster of dots such as lotus seed pods evokes extremely strong disgust when it is placed on human and animal skins. However, few empirical studies have examined the role of the background image, such as skin, in the generation of disgust. In this study, we investigated whether the orientation of background faces influences the disgust evoked by the dot pattern. The participants were asked to evaluate disgust to an upright, inverted (...) , or phase-scrambled face image with or without a cluster of dots on it and then complete a questionnaire measuring trypophobia proneness (Trypophobia Questionnaire). The results suggested that disgust was intensified by the background faces, especially by the upright faces. The intensification of disgust in the upright face was correlated positively with the Trypophobia Questionnaire scores. The results indicated a face-inversion effect on the disgust to the dot pattern, suggesting a significant role

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2018 i-Perception

5. CSF1R-Expressing Tumor-Associated Macrophages, Smoking and Survival in Lung Adenocarcinoma: Analyses Using Quantitative Phosphor-Integrated Dot Staining (PubMed)

CSF1R-Expressing Tumor-Associated Macrophages, Smoking and Survival in Lung Adenocarcinoma: Analyses Using Quantitative Phosphor-Integrated Dot Staining CSF1R-expressing tumor-associated macrophages (TAMs) induce a tumor-promoting microenvironment by regulating immunity. Evidence demonstrates that the expression and single nucleotide polymorphisms of CSF1R relate with survival and risk of lung cancer in never smokers. However, no previous studies have examined the association of CSF1R (...) expression in TAMs with mortality or whether the prognostic association differs according to smoking status in lung adenocarcinoma. Quantitative phosphor-integrated dot staining was used to precisely assess CSF1R expression in TAMs. Using 195 consecutive cases of lung adenocarcinoma, we examined the association of CSF1R expression with mortality and whether the prognostic association differs according to smoking status. We observed high expression levels of CSF1R in TAMs in 65 of 195 (33%) cases of lung

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2018 Cancers

6. Lessons From the Dot Contraceptive Efficacy Study: Analysis of the Use of Agile Development to Improve Recruitment and Enrollment for mHealth Research (PubMed)

is critical. Recruiting and enrolling participants for the Dot study involved making decisions based on research and analytic data, constant process modification, and close monitoring and evaluation of the effect of these modifications.Originally, the only option for women to enroll in the study was to do so over the phone with a study representative. On noticing low enrollment numbers, we examined the 7 steps from the time a woman received the recruitment message until she completed enrollment and made (...) Lessons From the Dot Contraceptive Efficacy Study: Analysis of the Use of Agile Development to Improve Recruitment and Enrollment for mHealth Research Smartphone apps that provide women with information about their daily fertility status during their menstrual cycles can contribute to the contraceptive method mix. However, if these apps claim to help a user prevent pregnancy, they must undergo similar rigorous research required for other contraceptive methods. Georgetown University's Institute

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2018 JMIR mHealth and uHealth

7. The role of awareness of repetition during the development of automaticity in a dot-counting task (PubMed)

The role of awareness of repetition during the development of automaticity in a dot-counting task This study examined whether being aware of the repetition of stimuli in a simple numerosity task could aid the development of automaticity. The numerosity task used in this study was a simple counting task. Thirty-four participants were divided into two groups. One group was instructed that the stimuli would repeat many times throughout the experiment. The results showed no significant differences

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2018 PeerJ

8. Connecting the Dots between Mechanosensitive Channel Abundance, Osmotic Shock, and Survival at Single-Cell Resolution (PubMed)

Connecting the Dots between Mechanosensitive Channel Abundance, Osmotic Shock, and Survival at Single-Cell Resolution Rapid changes in extracellular osmolarity are one of many insults microbial cells face on a daily basis. To protect against such shocks, Escherichia coli and other microbes express several types of transmembrane channels that open and close in response to changes in membrane tension. In E. coli, one of the most abundant channels is the mechanosensitive channel of large (...) conductance (MscL). While this channel has been heavily characterized through structural methods, electrophysiology, and theoretical modeling, our understanding of its physiological role in preventing cell death by alleviating high membrane tension remains tenuous. In this work, we examine the contribution of MscL alone to cell survival after osmotic shock at single-cell resolution using quantitative fluorescence microscopy. We conducted these experiments in an E. coli strain which is lacking all

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2018 Journal of bacteriology

9. Dynamic analysis of the interactions between Si/SiO2 quantum dots and biomolecules for improving applications based on nano-bio interfaces (PubMed)

Dynamic analysis of the interactions between Si/SiO2 quantum dots and biomolecules for improving applications based on nano-bio interfaces Due to their outstanding properties, quantum dots (QDs) received a growing interest in the biomedical field, but it is of major importance to investigate and to understand their interaction with the biomolecules. We examined the stability of silicon QDs and the time evolution of QDs - protein corona formation in various biological media (bovine serum albumin

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2018 Scientific reports

10. Toward high-fidelity coherent electron spin transport in a GaAs double quantum dot (PubMed)

Toward high-fidelity coherent electron spin transport in a GaAs double quantum dot In this paper, we investigate how to achieve high-fidelity electron spin transport in a GaAs double quantum dot. Our study examines fidelity loss in spin transport from multiple perspectives. We first study incoherent fidelity loss due to hyperfine and spin-orbit interaction. We calculate fidelity loss due to the random Overhauser field from hyperfine interaction, and spin relaxation rate due to spin-orbit (...) by the correction to the electron g-factor from the double dot potential, which can lead to a notable phase error. In all, our results should provide a useful guidance for future experiments on coherent electron spin transport.

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2018 Scientific reports

11. White and yellow dots as new trichoscopic signs of severe female androgenetic alopecia in dark skin phototypes. (PubMed)

White and yellow dots as new trichoscopic signs of severe female androgenetic alopecia in dark skin phototypes. Androgenetic alopecia or female pattern hair loss is the condition that most commonly leads to hair loss in adult females. The trichoscope is used for the early diagnosis of the disease. The study aims at finding a possible association between trichoscopic signs and disease severity in dark-skinned females.This was an observational study involving trichoscopic examination of 129 (...) females with different hair disorders.Clinical and trichoscopic examination revealed 79 patients with androgenetic alopecia. All patients showed hair shaft diameter diversity. The predominance of one hair per follicle was found in 97.4% (77/79), peripilar brown halo in 32.9% (26/79), peripilar white halo in 10.1% (8/79), and honeycomb-like scalp pigmentation in 17.7% (14/79) of patients, yellow dots in 15.2% (12/79), white dots in 20.3% (16/79), and hidden hair in 7.6% (6/79). Yellow dots and white

2018 International Journal of Dermatology

12. Motor Impairment and Developmental Psychotic Risk: Connecting the Dots and Narrowing the Pathophysiological Gap. (PubMed)

Motor Impairment and Developmental Psychotic Risk: Connecting the Dots and Narrowing the Pathophysiological Gap. The motor system in its manifold articulations is receiving increasing clinical and research attention. This is because motor impairments constitute a central, expressive component of the mental state examination and a key transdiagnostic feature indexing disease severity. Furthermore, within the schizophrenia spectrum, the integration of neurophysiological, developmental

2018 Schizophrenia bulletin

13. Tuning the Optical Properties of Silicon Quantum Dots via Surface Functionalization with Conjugated Aromatic Fluorophores (PubMed)

Tuning the Optical Properties of Silicon Quantum Dots via Surface Functionalization with Conjugated Aromatic Fluorophores Silicon Quantum Dots (SQDs) have recently attracted great interest due to their excellent optical properties, low cytotoxicity, and ease of surface modification. The size of SQDs and type of ligand on their surface has a great influence on their optical properties which is still poorly understood. Here we report the synthesis and spectroscopic studies of three families (...) energy transfer process, the emission color of the SQD core could be efficiently tuned and its emission quantum efficiency enhanced. To demonstrate the potential application of the synthesized SQDs for bioimaging of cancer cells, the water-soluble perylene- and pyrene-capped SQDs were examined for fluorescent imaging of HeLa cells. The SQDs were shown to be of low cytotoxicity.

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2018 Scientific reports

14. Multiple evanescent white dot syndrome following rabies vaccination: a case report. (PubMed)

Multiple evanescent white dot syndrome following rabies vaccination: a case report. To report a case of multiple evanescent white dot syndrome (MEWDS) following simultaneous rabies vaccination.Review of the clinical, laboratory, photographic, optical coherence tomographic (OCT), fundus autofluorescent, angiographic, electrophysiologic, and perimetric records of a patient suffering from MEWDS.A healthy 33-year-old Chinese female suffering from rapidly progressive visual loss of her left eye (...) associated with photopsia and a para-central scotoma, seven days after receiving simultaneous rabies vaccination. Both anterior segments and fundus examination were unremarkable. The findings on OCT, electrophysiology, and perimetry were pathognomonic for MEWDS.The clinical presentation and the benign course were consistent with the diagnosis of MEWDS. No other events could be identified as a cause, other than the rabies vaccination. This case may suggest an autoimmune basis for MEWDS in predisposed

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2018 BMC Ophthalmology

15. Choroidal neovascularisation triggered multiple evanescent white dot syndrome (MEWDS) in predisposed eyes. (PubMed)

Choroidal neovascularisation triggered multiple evanescent white dot syndrome (MEWDS) in predisposed eyes. Multiple evanescent white dot syndrome (MEWDS) is an inflammatory disease that can be associated with choroidalneovascularisation (CNV). However, few studies in the literature have described the occurrence of MEWDS in association with CNV. This paper discusses whether CNV can trigger MEWDS in a predisposed eye.A retrospective multicentric case series of six eyes in six patients with acute (...) onset of MEWDS and evidence of previous CNV was conducted between January 2015 and January 2017. All patients underwent ophthalmic examination including multimodal imaging at baseline and during follow-up.The mean age was 32.2±12.2 years. The majority of patients were women (5/1). In each case, MEWDS was diagnosed during a recurrence or occurrence of CNV secondary to choriocapillaritis, central serous chorioretinopathy or atrophic scar, presumably due to congenital toxoplasmosis. All patients were

2017 British Journal of Ophthalmology

16. CHARACTERIZATION AND CORRELATION OF "JAMPOL DOTS" ON ADAPTIVE OPTICS WITH FOVEAL GRANULARITY ON CONVENTIONAL FUNDUS IMAGING. (PubMed)

CHARACTERIZATION AND CORRELATION OF "JAMPOL DOTS" ON ADAPTIVE OPTICS WITH FOVEAL GRANULARITY ON CONVENTIONAL FUNDUS IMAGING. To describe features characteristic of multiple evanescent white dot syndrome (MEWDS) using adaptive optics scanning laser ophthalmoscopy (AOSLO).Six women (seven eyes) who presented with MEWDS between June 2014 and April 2017 underwent ophthalmologic examinations and multimodal imaging including infrared, AOSLO, and spectral domain optical coherence tomography.Bright (...) hyperreflective lesions on AOSLO throughout the course of MEWDS could be correlated to the hyperreflective dots of foveal granularity on infrared imaging without apparent corresponding changes on spectral domain optical coherence tomography. During the acute phase of MEWDS, extrafoveal hyperreflective dots were also visible on AOSLO and infrared and were associated with accumulations of hyperreflective material above the retinal pigment epithelium on spectral domain optical coherence tomography.Foveal

2017 Retina

17. DYNAMISM OF DOT SUBRETINAL DRUSENOID DEPOSITS IN AGE-RELATED MACULAR DEGENERATION DEMONSTRATED WITH ADAPTIVE OPTICS IMAGING. (PubMed)

DYNAMISM OF DOT SUBRETINAL DRUSENOID DEPOSITS IN AGE-RELATED MACULAR DEGENERATION DEMONSTRATED WITH ADAPTIVE OPTICS IMAGING. To investigate the natural history of dot subretinal drusenoid deposits (SDD) in age-related macular degeneration, using high-resolution adaptive optics scanning laser ophthalmoscopy.Six eyes of four patients with intermediate age-related macular degeneration were studied at baseline and 1 year later. Individual dot SDD within the central 30° retina were examined (...) affected by dot SDD, measured by the adaptive optics scanning laser ophthalmoscopy, increased in 5/6 eyes (from 2.31% to 5.08% in the most changed eye) and decreased slightly in 1/6 eye (from 10.67% to 10.54%). Dynamism, the absolute value of the areas affected by new and regressed lesions, ranged from 0.7% to 9.3%.Adaptive optics scanning laser ophthalmoscopy reveals that dot SDD, like drusen, are dynamic.

2017 Retina

18. Exercise Improves V[Combining Dot Above]O 2max and Body Composition in ADT-treated Prostate Cancer Patients. (PubMed)

Exercise Improves V[Combining Dot Above]O 2max and Body Composition in ADT-treated Prostate Cancer Patients. Prostate cancer is the most common cancer in men, and patients treated with androgen deprivation therapy (ADT) experience unfavorable changes in body composition and associated metabolic complications, which can increase the risk of cardiovascular disease. We examined the effect of a 6-month program of aerobic and resistance exercise aimed at improving body composition

2017 Medicine and science in sports and exercise

19. Benign Yellow Dot Maculopathy: A New Macular Phenotype. (PubMed)

Benign Yellow Dot Maculopathy: A New Macular Phenotype. To describe a novel macular phenotype that is associated with normal visual function.Retrospective, observational case series.Thirty-six affected individuals from 23 unrelated families.This was a retrospective study of patients who had a characteristic macular phenotype. Subjects underwent a full ocular examination, electrophysiologic studies, spectral-domain optical coherence tomography (OCT), and fundus autofluorescence imaging. Genomic (...) analyses were performed using haplotype sharing analysis and whole-exome sequencing.Visual acuity, retinal features, electroretinography, and whole-exome sequencing.Twenty-six of 36 subjects were female. The median age of subjects at presentation was 15 years (range, 5-59 years). The majority of subjects were asymptomatic and presented after a routine eye examination (22/36 subjects) or after screening because of a positive family history (13/36 subjects) or by another ophthalmologist (1/36 subjects

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2017 Ophthalmology

20. Intracellular ROS levels determine the apoptotic potential of keratinocyte by Quantum Dot via blockade of AKT Phosphorylation. (PubMed)

Intracellular ROS levels determine the apoptotic potential of keratinocyte by Quantum Dot via blockade of AKT Phosphorylation. Quantum dots (QDs) have shown great potential for biomedical use in a broad range including diagnostic agents. However, the regulatory mechanism of dermal toxicity is poorly understood. In this study, we investigated how QDs-induced apoptosis is regulated in human keratinocytes. We also examined the effect of carboxylic acid-coated QDs (QD 565 and QD 655) on reactive

2017 Experimental Dermatology

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