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DIABETES AND (FAT OR FATS OR CHOLESTEROL) AND CALORIES AND (IMPORTANCE OR COUNTING OR "LOSING WEIGHT" OR SIGNIFICANCE OR CARBS)

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1. Accuracy of Automatic Carbohydrate, Protein, Fat and Calorie Counting Based on Voice Descriptions of Meals in People with Type 1 Diabetes (PubMed)

Accuracy of Automatic Carbohydrate, Protein, Fat and Calorie Counting Based on Voice Descriptions of Meals in People with Type 1 Diabetes The aim of this work was to assess the accuracy of automatic macronutrient and calorie counting based on voice descriptions of meals provided by people with unstable type 1 diabetes using the developed expert system (VoiceDiab) in comparison with reference counting made by a dietitian, and to evaluate the impact of insulin doses recommended by a physician (...) compared to those introduced by the system that used the average characteristics of food products, although statistically significant, were low enough not to have a significant impact on insulin doses automatically calculated by the system. On the other hand, the glycemic control of patients was comparable regardless of whether the physician was using the system-estimated or the reference content of meals to determine insulin doses.

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2018 Nutrients

2. Centre for Evidence Based Medicine response to the report “Eat Fat, Cut The Carbs and Avoid Snacking to Reverse Obesity and Type 2 Diabetes”

Centre for Evidence Based Medicine response to the report “Eat Fat, Cut The Carbs and Avoid Snacking to Reverse Obesity and Type 2 Diabetes” Eating fat and cutting carbs - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website Eating fat and cutting carbs CEBM response to “Eat Fat, Cut The Carbs and Avoid Snacking to Reverse Obesity and Type 2 Diabetes” Initiatives to provide trustworthy evidence-based dietary (...) for health professionals developing their teaching of EBM. 5 - 7 December 2019 The 7th international conference in Sydney. 26 comments on “ Eating fat and cutting carbs ” Are you suggesting that the host of Doctors including some independent thinking NHS doctors are using LCHF (lower carb higher fat) are misguided. Do you doubt their blogs, patient case studies and sometimes their own significant weight loss? I see 3 parties – pharmaceutical companies with 10s of millions to lose – dietician aligned

2016 CEBM blog

3. Low-Fat Versus Low-Carb Diet: DIETFITS Show Both Can Work If They Are “Healthy”

levels LDL (bad cholesterol) declined more in the low-fat group whereas HDL (good cholesterol) increased more and triglycerides declined more in the low-carb group. Thus both diets were successful for weight loss and both improved risk markers for cardiovascular disease after a year. DIETFITS- Can Genes and Insulin resistance Predict Best Diet? Surprisingly, the study found no significant diet-genotype interaction and no diet-insulin secretion interaction with weight loss. This means that they could (...) and (sometimes) two eggs in an omelette. I am not promoting anything – I’m just saying what is working for US. Thanks for your interesting blog. says: I skimmed the actual study linked in your article. Noted that participants had to agree to being randomly assigned to low fat or low carb. To me, this suggests most were relatively indifferent as to which they had to cut back on to lose weight. This suggests one reason outcomes were similar. I’d guess, in general, the most successful dieters cut back on those

2018 The Skeptical Cardiologist

4. Type 2 diabetes can be reversed with a low-calorie diet

or dieticians. This trial involved 298 adults who had been diagnosed with type 2 diabetes within six years. Those that stuck with the program were more likely to lose weight (average 10kg was lost) and to go into remission compared to usual care. More than two-thirds of them were also able to stop both diabetic and high blood pressure tablets. These results were seen after one year. The challenge will be to see if the results can be maintained over the planned four year follow-up period. If successful (...) % of the intervention group compared to 39% of the usual care group. What does current guidance say on this issue? The NICE guideline on type 2 diabetes (2015) recommends the same dietary advice that is given to the general population. This includes eating a high-fibre, low glycaemic index, low-fat diet with plenty of fruit and vegetables. They encourage weight loss and exercise but do not specify very low-calorie diets to go into remission. What are the implications? This study shows that it is possible to achieve

2019 NIHR Dissemination Centre

5. Effects of a Calorie Restricted, Very Low Fat Plant-based Diet and Multi-component Exercise Program on Metabolic Health

Effects of a Calorie Restricted, Very Low Fat Plant-based Diet and Multi-component Exercise Program on Metabolic Health Effects of a Calorie Restricted, Very Low Fat Plant-based Diet and Multi-component Exercise Program on Metabolic Health - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Effects of a Calorie Restricted, Very Low Fat Plant-based Diet and Multi-component Exercise Program on Metabolic Health (PE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2016 Clinical Trials

6. Low fat or low carbohydrate diets seem just as effective for weight loss

weight-loss strategies. Prior research suggested that variations in the DNA sequence on three genes (PPARG, ADRB2, and FABP2) differ between those who respond better to low fat or low carbohydrate diets. Other research indicated that people with greater insulin resistance may fare better on low carbohydrate diets. What did this study do? The DIETFITS randomised controlled trial recruited 609 US adults (57% female) with overweight to obese BMI 28-40 (average 33). Exclusions included diabetes (...) that the person consumes 600kcal fewer per day than they would normally, in combination with intensive support and follow-up. NICE mention that lowering dietary fat content may be one approach to achieve this. Lowering carbohydrate is not mentioned. Very low-calorie diets are not routinely recommended. General advice is to tailor dietary changes to preference, not to use restrictive or nutritionally unbalanced diets, and encourage a healthy balanced diet in the long term. What are the implications

2019 NIHR Dissemination Centre

7. Dietary Fats and Cardiovascular Disease (PubMed)

and produced only a 3.5% reduction in serum cholesterol. There were 8% fewer men with CHD death or nonfatal myocardial infarction in the fat advice group compared with the no-fat advice group, not statistically significant but similar to what is predicted from the small decrease in serum cholesterol. Houtsmuller et al conducted a 6-year trial in patients with newly diagnosed diabetes mellitus that reduced saturated fat and replaced it with mainly polyunsaturated fat. Serum cholesterol decreased (...) with those with high saturated and low unsaturated fat intake. The current AHA/American College of Cardiology guideline is to decrease intake of saturated fat to 5% to 6% of total daily energy (calorie) intake for individuals with elevated LDL cholesterol concentration. The 2015 to 2020 Dietary Guidelines for Americans recommend consuming <10% of calories from saturated fat for the general population and replacing saturated fat with unsaturated fat. The average intake of saturated fat in adults

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2017 American Heart Association

8. Type 2 diabetes can be reversed with very low-calorie diet

nurses or dieticians. This trial involved 298 adults who had been diagnosed with type 2 diabetes within six years. Those that stuck with the program were more likely to lose weight (average 10kg was lost) and to go into remission compared to usual care. More than two-thirds of them were also able to stop both diabetic and high blood pressure tablets. These results were seen after one year. The challenge will be to see if the results can be maintained over the planned four year follow-up period (...) for 68% of the intervention group compared to 39% of the usual care group. What does current guidance say on this issue? The NICE guideline on type 2 diabetes (2015) recommends the same dietary advice that is given to the general population. This includes eating a high-fibre, low glycaemic index, low-fat diet with plenty of fruit and vegetables. They encourage weight loss and exercise but do not specify very low-calorie diets to go into remission. What are the implications? This study shows

2018 NIHR Dissemination Centre

9. Low-Carbohydrate, High-Protein, High-Fat Diets Rich in Livestock, Poultry and Their Products Predict Impending Risk of Type 2 Diabetes in Chinese Individuals that Exceed Their Calculated Caloric Requirement (PubMed)

to investigate the association of low-carbohydrate, high-fat and high-protein diets with type 2 diabetes (T2D) risk in populations consuming extra calories and those with normal caloric intake, We also determined whether the association is mediated by insulin resistance (IR) or β-cell dysfunction. A total of 3644 subjects in the Harbin People's Health Study (Cohort 1, 2008-2012) and 7111 subjects in the Harbin Cohort Study on Diet, Nutrition and Chronic Non-Communicable Diseases (Cohort 2, 2010-2015) were (...) Low-Carbohydrate, High-Protein, High-Fat Diets Rich in Livestock, Poultry and Their Products Predict Impending Risk of Type 2 Diabetes in Chinese Individuals that Exceed Their Calculated Caloric Requirement The evidence on the association between long-term low-carbohydrate, high-fat and high-protein diets and type 2 diabetes (T2D) is controversial. Until now, data is limited for Chinese populations, especially in considering the influence of extra energy intake. In this paper, we aimed

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2018 Nutrients

10. The Effect of a High-fat vs. High-sugar Diet on Liver Fat Accumulation and Metabolism

fat have fed volunteers excess calories, which are known to increase liver fat. The effect of specific dietary components, when consumed as part of a diet not containing excess calories, on liver fat accumulation remains unclear. Condition or disease Intervention/treatment Phase Fat; Liver NAFLD Other: High-fat, low-carbohydrate Other: Low-fat, high-carbohydrate Not Applicable Detailed Description: This research aims to investigate the role excessive consumption of specific macronutrients may play (...) The Effect of a High-fat vs. High-sugar Diet on Liver Fat Accumulation and Metabolism The Effect of a High-fat vs. High-sugar Diet on Liver Fat Accumulation and Metabolism - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2017 Clinical Trials

11. Efficacy of D-allulose on Weight and Fat Loss and Insulin Resistance in Non-diabetic Obese Subjects

control group with non-calorie sweetener erythritol 5 g 3 times a day before meal to right after meal (with any liquid) Total number: n = 60 Either males or females, non-diabetic, aged > 18 years old with BMI ≥ 25 kg/m2 Primary objectives Efficacy 1. Compare the efficacy of pure D-allulose (psicose) plus conventional therapy on 1.1 visceral fat area (VFA), subcutaneous fat area (SFA), total fat area (TFA) change 1.2 body weight, BMI and body fat percentage (with impedance method) change after 24 weeks (...) Efficacy of D-allulose on Weight and Fat Loss and Insulin Resistance in Non-diabetic Obese Subjects Efficacy of D-allulose on Weight and Fat Loss and Insulin Resistance in Non-diabetic Obese Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2016 Clinical Trials

12. Deletion of miR-150 Exacerbates Retinal Vascular Overgrowth in High-Fat-Diet Induced Diabetic Mice (PubMed)

mice were given a HFD (59% fat calories) or normal chow diet. Chronic HFD caused a decrease of serum miR-150 in WT mice. Mice on HFD for 7 months (both WT and miR-150-/-) had significant decreases in retinal light responses measured by electroretinograms (ERGs). The retinal neovascularization in miR-150-/--HFD mice was significantly higher compared to their age matched WT-HFD mice, which indicates that miR-150 null mutation exacerbates chronic HFD-induced neovascularization in the retina (...) Deletion of miR-150 Exacerbates Retinal Vascular Overgrowth in High-Fat-Diet Induced Diabetic Mice Diabetic retinopathy (DR) is the leading cause of blindness among American adults above 40 years old. The vascular complication in DR is a major cause of visual impairment, making finding therapeutic targets to block pathological angiogenesis a primary goal for developing DR treatments. MicroRNAs (miRs) have been proposed as diagnostic biomarkers and potential therapeutic targets for various

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2016 PloS one

13. Long-term effects of low-fat diets either low or high in protein on cardiovascular and metabolic risk factors: a systematic review and meta-analysis

groups had to receive a low-fat diet. The outcomes of interest included weight, blood pressure, and tests for blood levels of, for example, cholesterol, triglycerides, or glucose when fasting. The included trials had more female than male participants. Where reported, body mass index at baseline ranged from 27 to 40kg per m². Some trials included participants with type 2 diabetes. The percentage of carbohydrates in the high- and low-protein diets varied, with low-protein groups receiving higher (...) Protein; Cardiovascular Diseases /prevention & Cholesterol, HDL /blood; Cholesterol, LDL /blood; Databases, Factual; Diet, Fat-Restricted; Dietary Proteins /administration & Glycemic Index; Hemoglobin A, Glycosylated /analysis; Humans; Metabolic Syndrome X /prevention & Obesity /prevention & Randomized Controlled Trials as Topic; Risk Factors; Time Factors; Triglycerides /blood; Waist Circumference; Weight Loss; control; control; control; dosage AccessionNumber 12013020694 Date bibliographic record

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2013 DARE.

14. A 5-day high-fat, high-calorie diet impairs insulin sensitivity in healthy, young South asian men but not in caucasian men. (PubMed)

A 5-day high-fat, high-calorie diet impairs insulin sensitivity in healthy, young South asian men but not in caucasian men. South Asians (SAs) develop type 2 diabetes at a younger age and lower BMI compared with Caucasians (Cs). The underlying cause is still poorly understood but might result from an innate inability to adapt to the Westernized diet. This study aimed to compare the metabolic adaptation to a high-fat, high-calorie (HFHC) diet between both ethnicities. Twelve healthy, young lean (...) , suggesting lower hepatic insulin sensitivity in SAs. Furthermore, a 5-day HFHC diet decreased the insulin-stimulated (nonoxidative) glucose disposal rate only in SA. In skeletal muscle, no significant differences were found between groups in insulin/mammalian target of rapamycin signaling, metabolic gene expression, and mitochondrial respiratory chain content. Furthermore, no differences in (mobilization of) HTG and abdominal fat were detected. We conclude that HFHC feeding rapidly induces insulin

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2014 Diabetes

15. Effect of Time-Restricted Feeding on Fat Loss and Cardiometabolic Risk Factors in Overweight Adults

reduces body weight, improves blood sugar control, and reduces the risk of cardiovascular disease—even when food intake is matched to the control group or no weight loss occurs. Preliminary evidence suggests that TRF may also increase weight loss, fat loss, and reduce the risk of diabetes and cardiovascular disease in humans. This study will test whether TRF enhances fat loss and increases weight loss in adults with obesity, relative to conventional dieting alone. In addition, this study (...) : 14 weeks ] Changes in total fat mass, lean mass, bone mass, and regional values (kg), as measured by DXA. (This will be secondary to the assessment of fat loss and lean mass retention as specified above.) Secondary Outcome Measures : Fasting glucose [ Time Frame: 14 weeks ] Fasting glucose (mg/dl) Fasting insulin [ Time Frame: 14 weeks ] Fasting insulin (IU/L) HbA1c [ Time Frame: 14 weeks ] HbA1c (%) Lipids [ Time Frame: 14 weeks ] Total cholesterol (mg/dl), LDL cholesterol (mg/dl), HDL

2018 Clinical Trials

16. An integrative transcriptomic approach to identify depot differences in genes and microRNAs in adipose tissues from high fat fed mice (PubMed)

An integrative transcriptomic approach to identify depot differences in genes and microRNAs in adipose tissues from high fat fed mice Obesity contributes to metabolic disorders such as diabetes and cardiovascular disease. Characterization of differences between the main adipose tissue depots, white (WAT) [including subcutaneous (SAT) and visceral adipose tissue (VAT)] and brown adipose tissue (BAT) helps to identify their roles in obesity. Thus, we studied depot-specific differences in whole (...) transcriptome and miRNA profiles of SAT, VAT and BAT from high fat diet (HFD/45% of calories from fat) fed mice using RNA sequencing and small RNA-Seq. Using quantitative real-time polymerase chain reaction, we validated depot-specific differences in endoplasmic reticulum (ER) stress related genes and miRNAs using mice fed a HFD vs. low fat diet (LFD/10% of calories from fat). According to the transcriptomic analysis, lipogenesis, adipogenesis, inflammation, endoplasmic reticulum (ER) stress and unfolded

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2018 Oncotarget

17. A Trial of the Ideal Protein System Versus Low Fat Diet for Weight Loss

. In contrast, our previous studies have shown that despite comparable adherence to dietary goals, participants losing weight on a moderately carbohydrate-restricted, adequate protein regimen have improved cardiometabolic indicators as compared to those restricting fat. The RENEWAL trial will provide unique data on the efficacy of the Ideal Protein method (moderate carbohydrate restriction and adequate protein) for weight loss and improvement in cardiometabolic risk factors. The interventions will include (...) , 2018 See Sponsor: Tulane University Collaborator: Ideal Protein Information provided by (Responsible Party): Lydia A. Bazzano, Tulane University Study Details Study Description Go to Brief Summary: This study will examine whether, compared to a standard, low-fat, calorie-restricted diet intervention, the clinic-supported Ideal Protein weight loss method will result in greater weight loss and improvement in cardiometabolic risk factors over 3 months among obese adults with cardiovascular disease

2018 Clinical Trials

18. Impact of a High Saturated Fat Diet on Fasted Systemic and White Adipose Tissue Inflammatory Responses

, 2019 Sponsor: Loughborough University Information provided by (Responsible Party): Dr Oonagh Markey, Loughborough University Study Details Study Description Go to Brief Summary: This study will investigate the effect of a 7-day westernised high-fat (65% of kilocalories), high-calorie (150% of requirements) diet on markers of inflammation in the blood and white adipose tissue. Participants will firstly complete a 3-day weight maintenance phase (Days 1-3) before completing a 7-day high fat diet (...) intervention (Days 4-10). On days 4 and 11 participants will complete a laboratory visit where anthropometric measurements, blood and adipose samples will be collected. The investigators hypothesise that consuming a high-fat, high-calorie diet for 7 days will alter the inflammatory responses in white adipose tissue and will induce metabolic endotoxaemia / systemic inflammation. Condition or disease Intervention/treatment Phase Inflammation Obesity Inflammatory Response Cardiovascular Diseases Other: High

2018 Clinical Trials

19. Full-fat Yogurt and Glucose Tolerance

by (Responsible Party): Jana Kraft, University of Vermont Medical Center Study Details Study Description Go to Brief Summary: This study determines if substituting full-fat yogurt (i.e., whole, 3.25% fat) for non-fat yogurt in the diet can reduce the risk of type 2 diabetes and inflammation in association with changes in the composition of the gastrointestinal bacteria prediabetic male and female volunteers. The central hypothesis is that dairy fat impacts whole body glucose handling and insulin sensitivity (...) as well as inflammation both directly, and indirectly via influencing the gut microbiota composition. Condition or disease Intervention/treatment Phase Pre-Diabetes Dietary Supplement: Full-fat yogurt Dietary Supplement: Non-fat yogurt Not Applicable Detailed Description: The overall objective of this study is to determine if substituting full-fat yogurt (i.e., whole, 3.25% fat) for non-fat yogurt in the diet can i) improve whole body glucose handling and insulin sensitivity, ii) modulate systemic

2018 Clinical Trials

20. The Effect of a High Protein, High Fiber Dietary Supplement on Weight and Fat Loss

TGs ≥ 200 mg/dL (2.26 mmol/L) or a fasting total cholesterol ≥ 240 mg/dL (6.216 mmol/L) Fasting glucose ≥ 126 mg/dL Hypertension defined as untreated systolic blood pressure >160 mmHg, diastolic blood pressure >100 mmHg, or the use of prescription high blood pressure/hypertension medications within the last 6 months Type I or Type II diabetes or use of diabetes medication in a preventative setting. History of gastrointestinal dysfunction or surgery that may influence digestion or absorption (...) The Effect of a High Protein, High Fiber Dietary Supplement on Weight and Fat Loss The Effect of a High Protein, High Fiber Dietary Supplement on Weight and Fat Loss - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2017 Clinical Trials

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