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21. Novel Methylated DNA Markers Discriminate Advanced Neoplasia in Pancreatic Cysts: Marker Discovery, Tissue Validation, and Cyst Fluid Testing. (PubMed)

Novel Methylated DNA Markers Discriminate Advanced Neoplasia in Pancreatic Cysts: Marker Discovery, Tissue Validation, and Cyst Fluid Testing. Pancreatic cystic lesions (PCLs) may be precancerous. Those likely to harbor high-grade dysplasia (HGD) or pancreatic cancer (PC) are targets for surgical resection. Current algorithms to predict advanced neoplasia (HGD/PC) in PCLs lack diagnostic accuracy. In pancreatic tissue and cyst fluid (CF) from PCLs, we sought to identify and validate novel

2019 American Journal of Gastroenterology

22. Older age and larger cyst size in children with spontaneous rupture of periorbital dermoid cysts. (PubMed)

Older age and larger cyst size in children with spontaneous rupture of periorbital dermoid cysts. We analyzed clinical and histopathologic data of 97 pediatric patients who underwent excision of dermoid cysts. On review, 16.5% of the sample population demonstrated localized chronic inflammatory changes, including the presence of giant cells and epithelial disruption. These features were considered indicative of prior cyst rupture. Age at time of initial presentation was significantly older (...) and cyst size was significantly larger in patients with histopathologic signs of previous rupture. Longer time to presentation and time to excision were associated with increased odds of spontaneous rupture.Copyright © 2019 American Association for Pediatric Ophthalmology and Strabismus. Published by Elsevier Inc. All rights reserved.

2019 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

23. Diagnosis and Management of Pancreatic Cysts

Diagnosis and Management of Pancreatic Cysts 1 © 2018 by the American College of Gastroenterology The American Journal of GASTROENTEROLOGY CLINICAL GUIDELINES INTRODUCTION Pancreatic cysts are oft en detected on abdominal imaging per- formed for non-pancreatic indications. Th eir prevalence in an asymptomatic population is reported from 2.4 to 13.5% with increasing incidence with age ( 1 ). A review of abdominal mag- netic resonance imaging (MRIs) performed for non-pancreatic indications (...) in patients over the age of 70 showed a 40% incidence of incidental pancreatic cysts ( 2 ). Somewhat reassuring is the low prevalence of cysts >2 cm; in 25,195 subjects in fi ve studies the prevalence of cysts >2 cm was only 0.8% ( 3 ). Pancreatic cysts are increasingly being diagnosed because of the use of more abdomi- nal imaging and to the increased quality of that imaging. Th e overall incidence of pancreatic cancer-related mortality is fairly stable; thus, the increasing incidence of cysts is likely

2018 American College of Gastroenterology

24. Tolvaptan (Jinarc) - to slow the progression of cyst development and renal insufficiency of autosomal dominant polycystic kidney disease (ADPKD)

Tolvaptan (Jinarc) - to slow the progression of cyst development and renal insufficiency of autosomal dominant polycystic kidney disease (ADPKD) Cost-effectiveness of tolvaptan (Jinarc®) for the treatment of autosomal dominant polycystic kidney disease (ADPKD) The NCPE has issued a recommendation regarding the cost-effectiveness of tolvaptan (Jinarc®). Following assessment of the applicant’s submission, the NCPE recommends that tolvaptan (Jinarc®) not be considered for reimbursement unless cost (...) is for consideration by anyone who has a responsibility for commissioning or providing healthcare, public health or social care services. National Centre for Pharmacoeconomics September 20182 Summary In February 2018, Otsuka submitted a dossier to examine the cost-effectiveness of tolvaptan (Jinarc®) under the High Tech Drug Arrangements for Autosomal Dominant Polycystic Kidney Disease (APKD). ADPKD is an inherited form of kidney disease characterised by the progressive development of numerous renal cysts

2018 Pediatric Endocrine Society

25. Gingival cyst of the adult, lateral periodontal cyst, and botryoid odontogenic cyst: an updated systematic review. (PubMed)

Gingival cyst of the adult, lateral periodontal cyst, and botryoid odontogenic cyst: an updated systematic review. The aim of the present review was to integrate the available data published on gingival cyst of the adult (GCA), lateral periodontal cyst (LPC), and botryoid odontogenic cyst (BOC) into a comprehensive analysis of their clinical/radiological features. An electronic search was undertaken in July/2017. Eligibility criteria included publications having enough clinical/radiological

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2017 Oral diseases

26. The study of biochemical profile of cyst fluid and diffusion‐weighted magnetic resonance imaging in differentiating hepatic hydatid cysts from liver simple cysts (PubMed)

The study of biochemical profile of cyst fluid and diffusion‐weighted magnetic resonance imaging in differentiating hepatic hydatid cysts from liver simple cysts The aim of this study was to investigate the value of biochemical profile of cyst fluid and diffusion-weighted imaging (DWI) in differentiating hepatic hydatid cysts (HCs) from liver simple cysts.Forty-six patients underwent MR imaging. Twenty-nine patients had 29 hydatid cysts and 17 patients had liver simple cysts. Thirteen (...) patients with hydatid cysts and seven patients with liver simple cysts were evaluated with cyst fluid biochemical analysis. The concentration of glucose, protein, calcium ion (Ca2+ ) electrolyte, macroscopic appearance, and parasitological sediment were evaluated in this study.In the respect of biochemical analysis cyst fluid, the concentration of glucose and calcium ion of HCs was significantly higher than that of the liver simple cysts. In the respect of DWI, in the b 1000 s/mm2 value in respect

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2017 Journal of clinical laboratory analysis

27. Ovarian Cysts in Postmenopausal Women

Ovarian Cysts in Postmenopausal Women The Management of Ovarian Cysts in Postmenopausal Women Green-top Guideline No. 34 July 2016The Management of Ovarian Cysts in Postmenopausal Women This is the second edition of this guideline, which was previously published in 2003, and reviewed in 2010, under the title ‘Ovarian Cysts in Postmenopausal Women’. Executive summary of recommendations Diagnosis and significance of ovarian cysts in postmenopausal women How are ovarian cysts diagnosed (...) in postmenopausal women and what initial investigations should be performed? Clinicians should be aware of the different presentations and significance of ovarian cysts in postmenopausal women. [New 2016] In postmenopausal women presenting with acute abdominal pain, the diagnosis of an ovarian cyst accident should be considered (e.g. torsion, rupture, haemorrhage). [New 2016] It is recommended that ovarian cysts in postmenopausal women should be initially assessed by measuring serum cancer antigen 125 (CA125

2016 Royal College of Obstetricians and Gynaecologists

28. Immunohistochemical Analysis of Galectins-1, -3, and -7 in Periapical Granulomas, Radicular Cysts, and Residual Radicular Cysts. (PubMed)

Immunohistochemical Analysis of Galectins-1, -3, and -7 in Periapical Granulomas, Radicular Cysts, and Residual Radicular Cysts. Galectins play important roles in immunoinflammatory responses, but their participation in the development of periapical lesions remains unclear. This study aimed to evaluate the expressions of galectins-1, -3, and -7 in periapical lesions, correlating them with the intensity of the inflammatory infiltrate and the pattern of the cystic epithelium.Twenty periapical (...) granulomas (PGs), 20 radicular cysts (RCs), and 20 residual radicular cysts (RRCs) were submitted to immunohistochemistry using anti-galectin-1, -3, and -7 antibodies. The percentage of immunopositive cells in epithelial and connective tissues was determined.In connective tissue, PGs exhibited higher cytoplasmic/membrane expression of galectins-1 and -7 than RCs and RRCs (P < .05). There was higher nuclear expression of galectin-1 in PGs compared with RCs and RRCs (P < .05). The expression of galectins-1

2018 Journal of Endodontics

29. Methylene blue injection via percutaneous renal cyst puncture used in flexible ureteroscope for treatment of parapelvic cysts: A modified method for easily locating cystic wall. (PubMed)

Methylene blue injection via percutaneous renal cyst puncture used in flexible ureteroscope for treatment of parapelvic cysts: A modified method for easily locating cystic wall. To describe a modified technique for easily locating cystic wall during flexible ureteroscopic surgery for treatment of parapelvic renal cysts.Nineteen patients with symptomatic/asymptomatic parapelvic renal cyst were treated with modified or conventional flexible ureteroscopic surgery between February 2015 and March (...) 2017, and the differences of the 2 techniques were compared. The detailed surgical procedures and results, postoperative complications, and patients' follow-ups were evaluated.All the patients received endoscopic management by flexible ureteroscope successfully, without requiring another complicated surgery. The cysts were seen clearly in 9 patients with modified method. Two of ten patients who underwent conventional ureteroscopic surgery changed to the modified surgery intra-operatively since

2018 Urology

30. Comparative Expression of CD34, Intercellular Adhesion Molecule-1, and Podoplanin and the Presence of Mast Cells in Periapical Granulomas, Cysts, and Residual Cysts. (PubMed)

Comparative Expression of CD34, Intercellular Adhesion Molecule-1, and Podoplanin and the Presence of Mast Cells in Periapical Granulomas, Cysts, and Residual Cysts. The aim of the present study was to compare the immunoexpression of CD34, intercellular adhesion molecule-1 (ICAM-1), and podoplanin and the presence of mast cells with clinical, demographic, radiologic, and histologic features from periapical granulomas, periapical cysts, and residual cysts.Thirty-one lesions (5 granulomas, 15 (...) periapical cysts, and 11 residual cysts) were selected. Histologic sections in silanized slides were used for the immunohistochemical reactions. The analysis of the images was performed by using an optical microscope, and data were analyzed with 5% significance (P < .05).Cysts presented atrophic and hyperplastic epithelium in 11 cases (35.5%) and 15 cases (48.8%), respectively (P > .05). The intensity of the inflammatory infiltrate was similar when comparing the 3 groups (P > .05). CD34 and podoplanin

2018 Journal of Endodontics

31. Clinical significance of intrapancreatic choledochal cyst excision in surgical management of type I choledochal cyst (PubMed)

Clinical significance of intrapancreatic choledochal cyst excision in surgical management of type I choledochal cyst Objective To investigate the effectiveness of intrapancreatic choledochal cyst excision in treating type I choledochal cyst, and increase understanding of the need for thorough surgical management of the disease. Methods Primary and secondary (including multiple) surgical cases, treated between 2005 and 2015, were retrospectively analysed, and follow-up data of post-treatment (...) effectiveness to date were reviewed. Differences in curative effects were compared between whole and partial excision of the choledochal cyst. Results Out of 350 cases, patients with whole excision of the choledochal cyst ( n = 272) experienced no associated symptoms in the long-term (3/272 [1.1%] experienced stomach ache or fever). Patients with partial resection of the choledochal cyst ( n = 78) developed associated symptoms, including new cyst, calculus of the bile duct (51/78 [65.4

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2018 The Journal of international medical research

32. Confocal endomicroscopy and cyst fluid molecular analysis: Comprehensive evaluation of pancreatic cysts (PubMed)

Confocal endomicroscopy and cyst fluid molecular analysis: Comprehensive evaluation of pancreatic cysts Increases in the quality as well as utilization of cross-sectional imaging have led to rising diagnoses of pancreatic cystic lesions (PCL). Accurate presurgical diagnosis enables appropriate triage of PCLs. Unfortunately, current diagnostic approaches have suboptimal accuracy and may lead to unnecessary surgical resections or missed diagnoses of advanced neoplasia. Additionally, early (...) markers have also emerged as another diagnostic modality as the pattern of genetic alternations present in cyst fluid can provide both diagnostic and prognostic data. We propose that both techniques can be utilized to improve patient outcomes.

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2018 World journal of gastrointestinal endoscopy

33. Thyroid cyst mirror artifact mimicking a tracheal cyst on ultrasound in a patient with excessive trachea collapsibility (PubMed)

Thyroid cyst mirror artifact mimicking a tracheal cyst on ultrasound in a patient with excessive trachea collapsibility Mirror image artifact in ultrasound is not an unusual phenomenon. However, it is rarely seen in thyroid ultrasound because of the natural convexity of the tracheal surface. We report a mirror artifact during thyroid ultrasound in a patient with an excessively collapsible trachea. Minor pressure with the transducer made the trachea surface flat or concave, and then a cyst (...) in the thyroid was mirrored across the trachea, which mimicked an intratracheal cyst. This case illustrates how an unusual collapsible trachea can generate an image that simulates an intratracheal lesion during thyroid ultrasound.

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2018 Radiology Case Reports

34. Coexisting sublingual dermoid cyst and heterotopic gastrointestinal cyst: Case report (PubMed)

Coexisting sublingual dermoid cyst and heterotopic gastrointestinal cyst: Case report A heterotopic oral gastrointestinal cyst coexisting with a lingual dermoid cyst is a rare condition, with only 3 reported cases in the English-language literature. Clinically, both gastrointestinal and dermoid cysts tend to manifest as an asymptomatic swelling. Cysts above the mylohyoid often present with sublingual swelling, whereas those below the mylohyoid present with submental swelling. Increased (...) salivation, altered speech, dyspnea and difficulties in eating, swallowing and respiration may be present, depending on the size of the cyst. This paper describes the case of a 4-year-old girl presenting with swelling of the tongue and floor of the mouth that interfered with normal speech. Two cystic lesions were surgically excised using an intraoral approach, and recovery was uneventful. Histopathological examination of the specimens taken during surgery revealed the first, anterior cyst to be a dermoid

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2018 Journal of clinical and experimental dentistry

35. Symptom relief and not cyst reduction determines treatment success in aspiration sclerotherapy of hepatic cysts. (PubMed)

Symptom relief and not cyst reduction determines treatment success in aspiration sclerotherapy of hepatic cysts. To assess whether quantitative assessment of symptom reduction is a better outcome parameter than cyst volume reduction for treatment success in patients treated by aspiration sclerotherapy.We included patients with symptomatic, large (> 5 cm), hepatic cysts from a randomized controlled trial (NCT02048319). At baseline and 6 months after treatment, symptoms were assessed (...) with the polycystic liver disease questionnaire (PLD-Q) and we measured cyst volume using ultrasonography. Patient-reported change in health was assessed on a 5-point Likert scale (much worse to much better) after 6 months. We tested whether PLD-Q scores and cyst volumes changed after aspiration sclerotherapy (responsiveness). Changes in PLD-Q scores and cyst volume were compared with change in health as a measure of treatment success (discriminative ability). As secondary analysis, we compared baseline

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2018 European radiology

36. Splenic epithelial cyst mistaken with Hydatid cyst: A case report (PubMed)

Splenic epithelial cyst mistaken with Hydatid cyst: A case report Cystic lesions of the spleen are infrequent and usually diagnosed incidentally. These lesions are rare and their differential diagnosis is very wide. Splenic epithelial cysts are the most common type of primary splenic cyst (4%). Surgical treatment is indicated for cysts larger than 5 cm or symptomatic. Nowadays, spleen preserving surgery is the gold standard treatment considering the immunologic role of the spleen (...) and the increased risk of post-splenectomy infections.A 17 year old girl presented to the outpatient clinic with moderate left upper quadrant abdominal pain of 2 weeks duration with loss of appetite and denied fever, chills, sweating and jaundice. Abdominal examination showed tender splenomegaly. The abdominal imaging (Ultrasound, CT SCAN, MRI) was suggestive of hydatid cyst of the spleen, for which she received Albendazole for 1 month and then operated by laparotomy with partial resection and un-roofing

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2018 International journal of surgery case reports

37. Interactions between Macrophages and Cyst-Lining Epithelial Cells Promote Kidney Cyst Growth in <i>Pkd1</i>-Deficient Mice. (PubMed)

Interactions between Macrophages and Cyst-Lining Epithelial Cells Promote Kidney Cyst Growth in Pkd1-Deficient Mice. Autosomal-dominant polycystic kidney disease (ADPKD) is the leading inherited renal disease worldwide. The proproliferative function of macrophages is associated with late-stage cyst enlargement in mice with PKD; however, the way in which macrophages act on cyst-lining epithelial cells (CLECs) has not been well elucidated.We generated a rapid-onset PKD mouse model (...) by inactivating Pkd1 on postnatal day 10 (P10) and compared cell proliferation and differential gene expression in kidney tissues of the PKD mice and wild-type (WT) littermates.The cystic phenotype was dominant from P18. A distinct peak in cell proliferation in polycystic kidneys during P22-P30 was closely related to late-stage cyst growth. Comparisons of gene expression profiles in kidney tissues at P22 and P30 in PKD and WT mice revealed that arginine metabolism was significantly activated; 204

2018 Journal of the American Society of Nephrology

38. Mycobiome of Cysts of the Soybean Cyst Nematode Under Long Term Crop Rotation (PubMed)

Mycobiome of Cysts of the Soybean Cyst Nematode Under Long Term Crop Rotation The soybean cyst nematode (SCN), Heterodera glycines Ichinohe (Phylum Nematoda), is a major pathogen of soybean. It causes substantial yield losses worldwide and is difficult to control because the cyst protects the eggs which can remain viable for nearly a decade. Crop rotation with non-host crops and use of biocontrol organisms such as fungi and bacteria offer promising approaches, but remain hampered by lack (...) of knowledge of the biology of nematode parasitic organisms. We used a high-throughput metabarcoding approach to characterize fungal communities associated with the SCN cyst, a microenvironment in soil that may harbor both nematode parasites and plant pathogens. SCN cysts were collected from a long-term crop rotation experiment in Southeastern Minnesota at three time points over two growing seasons to characterize diversity of fungi inhabiting cysts and to examine how crop rotation and seasonal variation

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2018 Frontiers in microbiology

39. The prevalence of midline prostatic cysts and the relationship between cyst size and semen parameters among infertile and fertile men. (PubMed)

The prevalence of midline prostatic cysts and the relationship between cyst size and semen parameters among infertile and fertile men. When is the investigation and treatment of midline prostatic cysts (MPC) of clinical value in the work-up of males of infertile couples?With a prevalence of 10.2% in infertile men, MPC should be investigated according to a seminal algorithm detecting a MPC volume >0.117 ml, which may impair semen parameters, and could be treated to improve sperm count (...) , a longitudinal evaluation of 11 infertile men undergoing trans-rectal ultrasonically-guided cyst aspiration (TRUCA), semen analyses 1 and 3 months after TRUCA and a follow-up 1 year after TRUCA to assess natural pregnancy were performed.All subjects underwent, in our outpatient clinic, clinical, hormonal, scrotal and transrectal US evaluation and semen analysis within the same day. Of 693 males of infertile couples, 648 (37.1 ± 7.9 years, mean+SD) without genetic abnormalities were studied, along with 103

2018 Human Reproduction

40. Cyst infection in autosomal dominant polycystic kidney disease: penetration of meropenem into infected cysts. (PubMed)

Cyst infection in autosomal dominant polycystic kidney disease: penetration of meropenem into infected cysts. Cyst infection is a common and serious complication of autosomal dominant polycystic kidney disease (ADPKD) that is often refractory. Carbapenems are frequently needed to treat to patients with refractory cyst infection, but little is known about the penetration of newer water-soluble carbapenems into cysts. This study investigated the penetration of meropenem (MEPM) into infected cysts (...) in patients with ADPKD.Between August 2013 and January 2014, 10 ADPKD patients (14 infected cysts) receiving MEPM at Toranomon Hospital underwent drainage of infected cysts and definite cyst infection was confirmed through detection of neutrophils by cyst fluid analysis. The serum concentration of MEPM was measured just after intravenous administration and was compared with that in fluid aspirated from infected cysts.In the patients undergoing cyst drainage, the mean serum MEPM concentration was 35.2

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2018 BMC Nephrology

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