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22281. Keratin 17 mutation in pachyonychia congenita type 2 with early onset sebaceous cysts. (Abstract)

Keratin 17 mutation in pachyonychia congenita type 2 with early onset sebaceous cysts. Pachyonychia congenita (PC) is a group of autosomal dominant ectodermal dysplasias caused by mutations in four differentiation-specific keratin genes. Two major clinical subtypes of PC have been generally recognized. Symmetrically thickened fingernails and toenails are the defining characteristic of PC type 2 (PC-2) with onset at infancy. Pilosebaceous cysts are the best hallmark of PC-2, but they usually (...) occur at puberty.To report a Chinese pedigree of PC-2 with unusually early onset sebaceous cysts and to explore the genetic mutation and its phenotype.Exon 1 of keratin 17 was amplified by polymerase chain reaction (PCR) from genomic DNA from the three patients in the pedigree, the proband, his half-sister and his younger son, two unaffected members in the pedigree and 50 unrelated and unaffected people. PCR products were directly sequenced to detect the mutation.Direct sequencing of the PCR

2003 British Journal of Dermatology

22282. Recurrent 'sterile' verrucous cyst abscesses and epidermodysplasia verruciformis-like eruption associated with idiopathic CD4 lymphopenia. (Abstract)

Recurrent 'sterile' verrucous cyst abscesses and epidermodysplasia verruciformis-like eruption associated with idiopathic CD4 lymphopenia. Rupture of follicular (epidermoid) cysts is believed to be the consequence of bacterial infection. We report a 24-year-old man with idiopathic CD4 lymphopenia and chronic Mycobacterium avium intracellulare infection who developed multiple, recurring painful abscesses over the distal extremities that increased in number and severity when systemic steroid (...) and interferon-gamma treatment was instituted for interstitial lung disease. Cultures were consistently negative for microorganisms, but pathological examination revealed ruptured epidermoid cyst walls with human papillomavirus (HPV) viropathic changes (keratinocytes with perinuclear halos and abundant basophilic keratohyaline granules). Cutaneous examination showed numerous, widespread flat-topped papules and achromic macules over the extremities, head and neck. Nested polymerase chain reaction analysis

2003 British Journal of Dermatology

22283. The concomitant occurrence of multiple epidermal cysts, osteomas and thyroid gland nodules is not diagnostic for Gardner syndrome in the absence of intestinal polyposis: a clinical and genetic report. (Abstract)

The concomitant occurrence of multiple epidermal cysts, osteomas and thyroid gland nodules is not diagnostic for Gardner syndrome in the absence of intestinal polyposis: a clinical and genetic report. Gardner syndrome, a phenotypic variant of familial adenomatous polyposis, is characterized by the classical clinical triad of skin and soft tissue tumours, osteomas and intestinal polyposis, but disease patterns with pairs of these findings have also been reported. Different mutations (...) in the adenomatous polyposis coli (APC) gene have been shown to be associated with Gardner syndrome disease phenotypes. A 36-year-old patient presented with multiple epidermal cysts on the face, left ear lobe and neck, and the possible diagnosis of Gardner syndrome was based on the additional findings of two classical osteomas in the left radius and ulna and a cold non-malignant nodule of the thyroid gland. Intestinal polyposis was lacking at the time of examination. Major deletions but not microdeletions were

2003 British Journal of Dermatology

22284. Squamous cell carcinoma arising in a dermoid cyst of the ovary. (Abstract)

Squamous cell carcinoma arising in a dermoid cyst of the ovary. Unlike ordinary germ cell tumors of the ovary, squamous cell carcinoma arising in a dermoid affects elderly persons. Prognosis is poor when the disease has spread beyond the ovary.The case of a 67-year-old woman with stage III squamous cell carcinoma arising in a dermoid cyst of the ovary and extending to the serosa and myometrium of the uterus, pelvic peritoneum, the serosa, and muscularis of the distal ileum and penetrating (...) squamous cell carcinoma arising in a dermoid cyst of the ovary. This result is encouraging, but the best treatment for advanced cancer of this type has yet to be determined.

2003 Gynecologic Oncology

22285. Ovarian endometrioid adenocarcinoma arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy for breast cancer: a case report. (Abstract)

Ovarian endometrioid adenocarcinoma arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy for breast cancer: a case report. Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare.We herein report the case of a 67-year-old woman with a history of breast cancer, taking tamoxifen citrate 20 mg/day for 4 years, who underwent an operation for left ovarian tumor. The postoperative histological diagnosis (...) was endometrioid adenocarcinoma in an endometriotic cyst with a gradual transition of the degree of cellular atypia noted from typical endometriotic epithelium, to atypical endometriosis, and finally to adenocarcinoma.Tamoxifen may cause malignant transformation of endometriosis through atypical endometriosis even in the postmenopausal state. Atypical endometriosis may act as a precancerous lesion in the process of tamoxifen-induced malignant transformation of endometriosis.

2002 Gynecologic Oncology

22286. Comparative analysis of CA125, tissue polypeptide specific antigen, and soluble interleukin-2 receptor alpha levels in sera, cyst, and ascitic fluids from patients with ovarian carcinoma. (Abstract)

Comparative analysis of CA125, tissue polypeptide specific antigen, and soluble interleukin-2 receptor alpha levels in sera, cyst, and ascitic fluids from patients with ovarian carcinoma. The serum markers CA125, tissue polypeptide specific antigen (TPS), and soluble interleukin-2 receptor alpha (sIL-2Ralpha) concentrations were determined in sera, cyst, and ascitic fluids from patients with malignant and benign ovarian neoplasms.CA125, TPS, and sIL-2Ralpha concentrations were measured in sera (...) , cyst, and ascitic fluids by immunoassays in 67 patients with carcinoma and in 32 patients with benign ovarian neoplasms.CA125, TPS, and sIL-2Ralpha levels were elevated significantly in sera from patients who had ovarian carcinoma compared with patients who had benign neoplasms (P < 0.001). Patients who had International Federation of Gynecology and Obstetrics (FIGO) Stage III-IV disease had significantly higher serum levels for the markers studied compared with patients who had FIGO Stage I-II

2002 Cancer

22287. Loss of surface and cyst epithelial basement membranes and preneoplastic morphologic changes in prophylactic oophorectomies. Full Text available with Trip Pro

Loss of surface and cyst epithelial basement membranes and preneoplastic morphologic changes in prophylactic oophorectomies. The authors suggested that the loss of collagen IV and laminin-containing basement membrane and the loss of Disabled-2 (Dab2) expression were two critical events associated with morphologic dysplastic changes of the ovarian surface epithelium as a step in tumorigenicity. Both the basement membrane and Dab2, a candidate tumor suppressor of ovarian carcinoma, were involved (...) archived prophylactic oophorectomy specimens to verify whether the loss of Dab2 expression and the removal of the basement membrane that occur at the ovarian surface and inclusion cyst epithelia are molecular markers of preneoplastic lesions. Of the 36 samples containing identifiable ovarian surface epithelial components on slides, immunostaining was employed to evaluate the intactness of the basement membrane (periodic acid-Schiff [PAS], collagen IV, and laminin) and the expression of Dab2 and Cox-2

2003 Cancer

22288. Vallecular cyst and laryngomalacia in infants: report of six cases and airway management. (Abstract)

Vallecular cyst and laryngomalacia in infants: report of six cases and airway management. This report describes difficulties encountered in the airway management of six infants with concurrent vallecular cyst and laryngomalacia. It is hoped that our experience will assist others in the management of such patients.

2002 Anesthesia and Analgesia

22289. Severe hypernatremia after hypertonic saline irrigation of hydatid cysts. (Abstract)

Severe hypernatremia after hypertonic saline irrigation of hydatid cysts. Patients with iatrogenic hypernatremia and serum sodium levels >170 mmol/L either die or sustain severe central nervous system damage. We report the first case of an adult patient who survived an extreme iatrogenic acute hypernatremia (200 mmol/L) resulting from a hypertonic saline irrigation of multiple intraabdominal hydatid cysts. It is a unique report of an intraoperatively developed serum sodium increase without

2002 Anesthesia and Analgesia

22290. Choledochal Cyst: Is Complete Excision of the Intrapancreatic Cyst Necessar Full Text available with Trip Pro

Choledochal Cyst: Is Complete Excision of the Intrapancreatic Cyst Necessar 9830584 1999 01 28 2008 11 20 0894-8569 11 1 1998 HPB surgery : a world journal of hepatic, pancreatic and biliary surgery HPB Surg Choledochal cyst: is complete excision of the intrapancreatic cyst necessary? 61-3 Millar A A Department Paediatric Surgery, Red Cross Children's Hospital, Rondebosch, South Africa. Cywes S S eng Comparative Study Journal Article United States HPB Surg 9002972 0894-8569 IM Choledochal Cyst

1998 HPB Surgery

22291. Breast cancer risk with cyst type in cystic disease of the breast. Consistency of cyst type needs to be known. Full Text available with Trip Pro

Breast cancer risk with cyst type in cystic disease of the breast. Consistency of cyst type needs to be known. 9329316 1997 10 22 2008 11 20 0959-8138 315 7107 1997 Aug 30 BMJ (Clinical research ed.) BMJ Breast cancer risk with cyst type in cystic disease of the breast. Consistency of cyst type needs to be known. 545 Ebbs S S Bates T T eng Comment Letter England BMJ 8900488 0959-8138 AIM IM BMJ. 1997 Mar 29;314(7085):925-8 9099114 Breast Neoplasms etiology Female Fibrocystic Breast Disease

1997 BMJ : British Medical Journal

22292. Breast cancer risk with cyst type in cystic disease of the breast. Larger study found no association between cyst type and breast cancer. Full Text available with Trip Pro

Breast cancer risk with cyst type in cystic disease of the breast. Larger study found no association between cyst type and breast cancer. 9329317 1997 10 22 2013 11 21 0959-8138 315 7107 1997 Aug 30 BMJ (Clinical research ed.) BMJ Breast cancer risk with cyst type in cystic disease of the breast. Larger study found no association between cyst type and breast cancer. 545-6 Dixon J M JM McDonald C C Elton R A RA Miller W R WR eng Comment Letter England BMJ 8900488 0959-8138 9NEZ333N27 Sodium

1997 BMJ : British Medical Journal

22293. Loss of the polycystic kidney disease (PKD1) region of chromosome 16p13 in renal cyst cells supports a loss-of-function model for cyst pathogenesis. Full Text available with Trip Pro

Loss of the polycystic kidney disease (PKD1) region of chromosome 16p13 in renal cyst cells supports a loss-of-function model for cyst pathogenesis. It is not known whether mutations in the PKD1 gene cause autosomal dominant polycystic kidney disease (PKD) by an activating (gain-of-function) or an inactivating (loss-of-function) model. We analyzed DNA from cyst epithelial cells for loss of heterozygosity (LOH) in the PKD1 region of chromosome 16p13 using microsatellite markers. 29 cysts from (...) four patients were studied. Five cysts from three patients had chromosome 16p13 LOH. Four of the cysts had loss of two chromosome 16p13 markers that flank the PKD1 gene. In two patients, microsatellite analysis of family members was consistent with loss of the wild-type copy of PKD1 in the cysts. In the third patient, 16p13 LOH was detected in three separate cysts, all of which showed loss of the same alleles. Chromosome 3p21 LOH was detected in one cyst. No LOH was detected in four other genomic

1997 Journal of Clinical Investigation

22294. Pituitary-directed leukemia inhibitory factor transgene forms Rathke's cleft cysts and impairs adult pituitary function. A model for human pituitary Rathke's cysts. Full Text available with Trip Pro

Pituitary-directed leukemia inhibitory factor transgene forms Rathke's cleft cysts and impairs adult pituitary function. A model for human pituitary Rathke's cysts. Leukemia inhibitory factor (LIF) and LIF receptors are expressed in adenohypophyseal cells and LIF regulates pituitary hormone transcription and cell replication in vitro. Therefore, transgenic mice expressing pituitary-directed LIF driven by the rat growth hormone (GH) promoter were generated to evaluate the impact of LIF (...) by in situ hybridization. ACTH cells increased 2.2-fold, whereas gonadotrophs and thyrotrophs were unchanged. Serum GH was undetectable (< 0.78 ng/ml), PRL levels were one third of WT (P < 0.05), IGF-I levels were 30% of WT (P < 0. 001), and T4 was normal. 10 human pituitary Rathke's cysts studied all showed conclusive LIF immunoreactivity in cyst-lining cells. Thus, intrapituitary murine LIF overexpression causes cystic invaginations from the anterior wall of Rathke's cleft, suggesting failed

1997 Journal of Clinical Investigation

22295. Simple renal cysts in hypertensive patients: relation between cyst growing and anti-hypertensive therapy. (Abstract)

Simple renal cysts in hypertensive patients: relation between cyst growing and anti-hypertensive therapy. The study investigates relationship between simple renal cyst enlargement studied by ultrasonography and anti-hypertensive treatment. To this purpose we enrolled 42 patients with newly diagnosed hypertension affected by simple renal cysts. Fourteen were randomly assigned to treatment with ACE-Inhibitors (group 1), twelve to diuretics (group 2) and sixteen to Ca-Antagonists (group 3 (...) ). Patient performed a basal ultrasonography to evaluate basal cyst dimension before starting anti-hypertensive treatment. Following 12 months of the anti-hypertensive regimen, a new echograph was performed to evaluate changes in cyst size. A control group consisting of 15 patients with normal blood pressure and simple renal cysts was enrolled (group 0). An enlargement of cysts was detected in all patients. However, the enlargement observed in patients treated by Ca-Antagonists was significantly greater

2003 International journal of immunopathology and pharmacology Controlled trial quality: uncertain

22296. Sonography of fetal choroid plexus cysts: detection depends on cyst size and gestational age. (Abstract)

Sonography of fetal choroid plexus cysts: detection depends on cyst size and gestational age. To establish diagnostic criteria for the diagnosis of fetal choroid plexus cysts across gestation.Prenatal sonographic images of 166 fetuses without choroid plexus cysts were prospectively collected from 13 weeks to term. Texture characteristics of the choroid plexus regions were analyzed to quantify changes as a function of gestational age. A set of 20 fetal sonographic images with choroid plexus (...) cysts were used to create cyst prototypes (1.5-2.5 mm), which were randomly embedded into normal choroid plexus images from varying gestational ages. A test set of 544 images was created, which included 408 images with choroid plexus cysts and 136 images without choroid plexus cysts. Four observers following a blinded study design evaluated the presence of choroid plexus cysts in the images. The influence of cyst size and gestational age on the detection of cysts was measured with receiver operating

2003 Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine Controlled trial quality: uncertain

22297. Colonization of Soybean Cyst Nematode Females, Cysts, and Gelatinous Matrices by the Fungus Verticillium lecanii Full Text available with Trip Pro

Colonization of Soybean Cyst Nematode Females, Cysts, and Gelatinous Matrices by the Fungus Verticillium lecanii Heterodera glycines was grown in monoxenic culture on soybean roots and then inoculated with the antagonistic fungus Verticillium lecanii. Use of root explant cultures allowed evaluation of the fungus-nematode interaction with the nematode attached to roots or removed from the host, and avoided contamination with other fungi. From 16 hours to 14 days following inoculation, female (...) and cyst samples were examined with the light microscope, or prepared for either conventional or low-temperature scanning electron microscopy. Within 16 hours, hyphae had begun colonizing the gelatinous matrices (GM). The fungus proliferated in the GM of some specimens within a week, but was rarely seen in unhatched eggs. Fungus penetration holes in female and cyst walls were observed 3 days after inoculation; penetration through nematode orifices was not seen at that time. More cysts than females were

1998 Journal of nematology

22298. Cyst fluid analysis in the differential diagnosis of pancreatic cysts. A comparison of pseudocysts, serous cystadenomas, mucinous cystic neoplasms, and mucinous cystadenocarcinoma. Full Text available with Trip Pro

Cyst fluid analysis in the differential diagnosis of pancreatic cysts. A comparison of pseudocysts, serous cystadenomas, mucinous cystic neoplasms, and mucinous cystadenocarcinoma. Pancreatic cystic lesions include inflammatory pseudocysts, benign serous tumors, and mucinous neoplasms, some of which are malignant. Clinical and radiologic indices are often inadequate to discriminate reliably among these possibilities. In an attempt to develop new preoperative diagnostic criteria to assist (...) in decisions regarding therapy, the authors have performed cyst fluid analysis for tumor markers (carcinoembryonic antigen: CEA, CA 125, and CA 19.9), amylase content, amylase isoenzymes, relative viscosity, and cytology on 26 pancreatic cysts. The cases included nine pseudocysts, five serous cystadenomas, 4 mucinous cystic neoplasms, 7 mucinous cystadenocarcinomas, and one mucinous ductal adenocarcinoma with cystic degeneration. Carcinoembryonic antigen levels were high (> 367) in all benign and malignant

1993 Annals of Surgery

22299. Albendazole treatment of pulmonary hydatid cysts in naturally infected sheep: a study with relevance to the treatment of hydatid cysts in man. Full Text available with Trip Pro

Albendazole treatment of pulmonary hydatid cysts in naturally infected sheep: a study with relevance to the treatment of hydatid cysts in man. Albendazole was given orally to sheep with naturally occurring live pulmonary and hepatic cysts. The viability of pulmonary cysts was established before treatment by thoracotomy and needle puncture. Both 10 and 20 mg/kg/day doses were found effective in that no viable protoscoleces were found after six weeks' treatment in either group while untreated (...) controls still had viable cysts. In addition, treated animals showed macroscopic and electron microscopic changes. Bone marrow toxicity probably occurred in two sheep.

1985 Thorax

22300. Choledochal cyst or pancreatic (retention) cyst: a case report. (Abstract)

Choledochal cyst or pancreatic (retention) cyst: a case report. Right upper quadrant cystic lesions can be difficult to differentiate using noninvasive imaging modalities. The following case report discusses the common cystic lesions of the hepatoduodenal ligament and right sided pancreas.

2003 Journal of Gastrointestinal Surgery

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