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Cyclic Lipopeptide

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81. Acute Angioedema Triggered by Daptomycin (PubMed)

Acute Angioedema Triggered by Daptomycin Daptomycin is a cyclic lipopeptide antibiotic, frequently administered for Staphylococcus aureus bloodstream infections. Numerous studies have shown that daptomycin is relatively safe and well tolerated. Serious adverse events possibly related to this antimicrobial compound are rare. We report a case of acute angioedema triggered by daptomycin.A 60-year-old woman with S. aureus bacteremia without identified source was treated intravenously with high-dose

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2016 Infectious diseases and therapy

82. Molecular bases determining daptomycin resistance-mediated re-sensitization to β-lactams ("see-saw effect") in MRSA. (PubMed)

Molecular bases determining daptomycin resistance-mediated re-sensitization to β-lactams ("see-saw effect") in MRSA. Antimicrobial resistance is recognized as one of the principal threats to public health worldwide, yet the problem is increasing. Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) strains are among the most difficult to treat in clinical settings due to the resistance of MRSA to nearly all available antibiotics. The cyclic anionic lipopeptide antibiotic

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2016 Antimicrobial Agents and Chemotherapy

83. Evaluating the Effects of Surotomycin Treatment on C. difficile Toxin A and B Production, Immune Response, and Morphologic Changes. (PubMed)

Evaluating the Effects of Surotomycin Treatment on C. difficile Toxin A and B Production, Immune Response, and Morphologic Changes. Surotomycin is a cyclic lipopeptide in development for Clostridium difficile-associated diarrhea. This study aimed to assess the impact of surotomycin exposure on C. difficile toxin A and B concentrations and the associated changes in immune response in comparison to vancomycin and metronidazole. Time-kill curve assays were performed using strain R20291 (BI/NAP1

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2016 Antimicrobial Agents and Chemotherapy

84. Pharmacokinetics of Micafungin During Continuous Venovenous Hemofiltration

by (Responsible Party): Florian Thalhammer, Medical University of Vienna Study Details Study Description Go to Brief Summary: Micafungin is a cyclic lipopeptide antifungal agent of the echinocandin class. Members of this class of antifungal agents are known to inhibit the synthesis of glucan polymers in fungal cell walls. The spectrum of activity of micafungin includes Candida (all species, including strains resistant to fluconazole), Aspergillus, and Pneumocystis. In intensive care patients continuous

2015 Clinical Trials

85. Cellular uptake and localization of polymyxins in renal tubular cells using rationally designed fluorescent probes. (PubMed)

Cellular uptake and localization of polymyxins in renal tubular cells using rationally designed fluorescent probes. Polymyxins are cyclic lipopeptide antibiotics that serve as a last line of defense against Gram-negative bacterial superbugs. However, the extensive accumulation of polymyxins in renal tubular cells can lead to nephrotoxicity, which is the major dose-limiting factor in clinical use. In order to gain further insights into the mechanism of polymyxin-induced nephrotoxicity, we have

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2015 Antimicrobial Agents and Chemotherapy

86. Daptomycin for the treatment of osteomyelitis and orthopaedic device infections: real-world clinical experience from a European registry (PubMed)

Daptomycin for the treatment of osteomyelitis and orthopaedic device infections: real-world clinical experience from a European registry Osteomyelitis is a serious infection predominantly caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Orthopaedic device-related infections are complex and require a careful combination of surgical intervention and antimicrobial therapy. Daptomycin, a cyclic lipopeptide, effectively penetrates soft tissue and bone

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2015 European Journal of Clinical Microbiology & Infectious Diseases

87. Isolation and Synthesis of Laxaphycin B-Type Peptides: A Case Study and Clues to Their Biosynthesis (PubMed)

Isolation and Synthesis of Laxaphycin B-Type Peptides: A Case Study and Clues to Their Biosynthesis The laxaphyci's B family constitutes a group of five related cyclic lipopeptides isolated from diverse cyanobacteria from all around the world. This group shares a typical structure of 12 amino acids from the l and d series, some of them hydroxylated at the beta position, and all containing a rare beta-amino decanoic acid. Nevertheless, they can be differentiated due to slight variations

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2015 Marine drugs

88. Nonribosomal Peptides, Key Biocontrol Components for Pseudomonas fluorescens In5, Isolated from a Greenlandic Suppressive Soil (PubMed)

microcosm experiments. Furthermore, complex microbial behaviors were highlighted. Whereas nunamycin was demonstrated to inhibit the mycelial growth of R. solani Ag3, but not that of Pythium aphanidermatum, nunapeptin instead inhibited P. aphanidermatum but not R. solani Ag3. Moreover, the synthesis of nunamycin by P. fluorescens In5 was inhibited in the presence of P. aphanidermatum. Further characterization of the two peptides revealed nunamycin to be a monochlorinated 9-amino-acid cyclic lipopeptide (...) with similarity to members of the syringomycin group, whereas nunapeptin was a 22-amino-acid cyclic lipopeptide with similarity to corpeptin and syringopeptin.Crop rotation and systematic pest management are used to only a limited extent in Greenlandic potato farming. Nonetheless, although plant-pathogenic fungi are present in the soil, the farmers do not experience major plant disease outbreaks. Here, we show that a Greenlandic potato soil is suppressive against Rhizoctonia solani, and we unravel the key

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2015 mBio

89. Factors Influencing Production of Fusaristatin A in Fusarium graminearum (PubMed)

Factors Influencing Production of Fusaristatin A in Fusarium graminearum Fusarium graminearum is a ubiquitous plant pathogen, which is able to produce several bioactive secondary metabolites. Recently, the cyclic lipopeptide fusaristatin A was isolated from this species and the biosynthetic gene cluster identified. Fusaristatin A consists of a C24 reduced polyketide and the three amino acids dehydroalanine, β-aminoisobutyric acid and glutamine and is biosynthesized by a collaboration

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2015 Metabolites

90. Mode of Action and Bactericidal Properties of Surotomycin against Growing and Non-growing Clostridium difficile. (PubMed)

Mode of Action and Bactericidal Properties of Surotomycin against Growing and Non-growing Clostridium difficile. Surotomycin (CB-183,315), a cyclic lipopeptide, is in phase 3 clinical development for the treatment of Clostridium difficile infection. We report here the further characterization of the in vitro mode of action of surotomycin, including its activity against growing and nongrowing C. difficile. This was assessed through time-kill kinetics, allowing a determination of the effects

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2015 Antimicrobial Agents and Chemotherapy

91. Mutations Associated With Reduced Surotomycin Susceptibility in Clostridium difficile and Enterococcus species. (PubMed)

Mutations Associated With Reduced Surotomycin Susceptibility in Clostridium difficile and Enterococcus species. Clostridium difficile infection (CDI) is an urgent public health concern causing considerable clinical and economic burdens. CDI can be treated with antibiotics, but recurrence of the disease following successful treatment of the initial episode often occurs. Surotomycin is a rapidly bactericidal cyclic lipopeptide antibiotic that is in clinical trials for CDI treatment and that has

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2015 Antimicrobial Agents and Chemotherapy

92. A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin (PubMed)

A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin LiaR is a 'master regulator' of the cell envelope stress response in enterococci and many other Gram-positive organisms. Mutations to liaR can lead to antibiotic resistance to a variety of antibiotics including the cyclic lipopeptide daptomycin. LiaR is phosphorylated in response to membrane stress to regulate downstream target operons. Using DNA footprinting

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2015 Nucleic acids research

93. The safety and efficacy of daptomycin versus other antibiotics for skin and soft-tissue infections: a meta-analysis of randomised controlled trials. (PubMed)

The safety and efficacy of daptomycin versus other antibiotics for skin and soft-tissue infections: a meta-analysis of randomised controlled trials. Daptomycin, a cyclic lipopeptide that exhibits rapid, concentration-dependent bactericidal activity in vitro against a broad spectrum of Gram-positive pathogens, has now, since 2003, been approved in more than 70 countries and regions to treat skin and soft-tissue infections (SSTIs). The purpose of this meta-analysis was to compare the safety

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2014 BMJ open

94. Surotomycin Demonstrates Low In Vitro Frequency of Resistance and Rapid Bactericidal Activity in Clostridium difficile, Enterococcus faecalis and Enterococcus faecium. (PubMed)

Surotomycin Demonstrates Low In Vitro Frequency of Resistance and Rapid Bactericidal Activity in Clostridium difficile, Enterococcus faecalis and Enterococcus faecium. Surotomycin (CB-183,315) is an orally administered, minimally absorbed, selective bactericidal cyclic lipopeptide in phase 3 development for the treatment of Clostridium difficile-associated diarrhea. The aim of this study was to evaluate the emergence of resistance in C. difficile (ATCC 700057 and three recent clinical isolates

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2014 Antimicrobial Agents and Chemotherapy

95. Musculoskeletal Safety Outcomes of Patients Receiving Daptomycin with HMG-CoA Reductase Inhibitors. (PubMed)

Musculoskeletal Safety Outcomes of Patients Receiving Daptomycin with HMG-CoA Reductase Inhibitors. Daptomycin, a cyclic lipopeptide antibiotic, and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are commonly administered in the inpatient setting and are associated with creatine phosphokinase (CPK) elevations, myalgias, and muscle weakness. Safety data for coadministration of daptomycin with statins are limited. To determine the safety of coadministration

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2014 Antimicrobial Agents and Chemotherapy

96. Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Soft Tissue Infections Due to Gram Positive Bacteria With Various Degrees of Renal Failure

at an optimized dosage regimen. Daptomycin is the first representative of a new family of antibiotics, the cyclic lipopeptides. Its bactericidal effect against Gram-positive bacteria, including meticillin-resistant strains, and its low renal toxicity, make it a useful antibiotic in critically ill patients having infections due to resistant Gram positive strains. Unfortunately, no PK study has been performed in infected critically ill patients without renal replacement therapy. A vast array

2014 Clinical Trials

97. Draft Genome Sequence of Pseudomonas mediterranea Strain CFBP 5447T, a Producer of Filmable Medium-Chain-Length Polyhydroxyalkanoates (PubMed)

Draft Genome Sequence of Pseudomonas mediterranea Strain CFBP 5447T, a Producer of Filmable Medium-Chain-Length Polyhydroxyalkanoates Pseudomonas mediterranea strain CFBP 5447(T) is a phytopathogenic bacterium isolated from tomato plants affected by pith necrosis disease. Moreover, its ability to produce medium-chain-length polyhydroxyalkanoates (mcl-PHAs) in culture from different carbon sources and valuable microbial products, such as cyclic lipopeptides, has been well documented. Here, we

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2014 Genome Announcements

98. Enterococcal Infections (Overview)

, tigecycline) with activity against many VRE strains have improved this situation, but resistance to these agents has already been described. A mutation (G2576U) in the domain V of the 23S rRNA is responsible for linezolid resistance, [ ] whereas resistance to quinupristin-dalfopristin may be the result of several mechanisms: modification of enzymes, active efflux, and target modification. Resistance of E faecalis and E faecium to daptomycin, a newer cyclic lipopeptide antibiotic that acts on the bacterial

2014 eMedicine.com

99. Enterococcal Infections (Diagnosis)

, tigecycline) with activity against many VRE strains have improved this situation, but resistance to these agents has already been described. A mutation (G2576U) in the domain V of the 23S rRNA is responsible for linezolid resistance, [ ] whereas resistance to quinupristin-dalfopristin may be the result of several mechanisms: modification of enzymes, active efflux, and target modification. Resistance of E faecalis and E faecium to daptomycin, a newer cyclic lipopeptide antibiotic that acts on the bacterial

2014 eMedicine.com

100. Colobreathe (colistimethate sodium)

Alanine aminotransferase ANCOVA Analysis of Covariance API Active Pharmaceutical Ingredient AR Assessment report AST Aspartate aminotransferase AUC Area under the concentration-time curve BMI Body mass index BSAC British Society for Antimicrobial Therapy BUN Blood urea nitrogen C Colistin cAMP Cyclic adenosine monophosphate CEP Certificate of Suitability CF Cystic fibrosis CFTR Cystic Fibrosis Transmembrane Conductance Regulator CFQ CFQ – Cystic Fibrosis Questionnaire CFQ-R Cystic Fibrosis (...) be delivered by a multi-dose DPI (Clickhaler, Innovata biomed) but this required administration of 32 doses (each dose 5 mg gentamicin) over 30 minutes. In the current application a novel unit-dose DPI - Turbospin DPI – has been used to deliver 125 mg (equivalent to 1,662,500 IU) colistimethate sodium per dose from gelatine capsules. About the product Polymyxins are a group of lipopeptide antibiotics isolated from the spore-forming soil bacterium Bacillus polymyxa. Five major, chemically distinct members

2012 European Medicines Agency - EPARs

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