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Cutaneous Candidiasis

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161. Autoimmune Hepatitis

100,000 inhabitants in Europe and is increasing in both women and men (II-2) AIH can affect all populations and all age groups (II-2) Clinical spectrum Clinical features of AIH In the early 1950s, a novel type of chronic hepatitis with several particular features, such as a predilection for young women, a progressiveandusuallyfataloutcomeaccompaniedbyarthralgia, endocrine dysfunction, cutaneous striae and acne, and very high levels of immunoglobulins in the serum that correlated with an excess (...) liver injury; TNF, tumour necrosis factor; HCV, hepatitis C virus; APECED, autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; APS-1, autoimmune polyglandular syndrome type 1. Clinical Practice Guidelines 974 Journal of Hepatology 2015 vol. 63 j 971–1004of AIH [56]. In this regard, the name ‘‘overlap’’ that strongly sug- gests the presence of two distinct diseases could be a misnomer. It should be kept in mind that ‘‘variant forms’’ of AIH should not be over-diagnosed in order

2015 European Association for the Study of the Liver

162. Liver transplantation

choriomeningitis virus Parvovirus B19 Rabies West Nile virus Fungi Aspergillus spp. Candida spp. Coccidioides immitis Cryptococcus neoformans Histoplasma capsulatum Scopulariopsis brevicaulis Zygomycetes (Mucor) Bacteria* Gram-negative: Pseudomonas, Acinetobacter, Legionella, Klebsiella, Ehrlichia, Serratia, Escherichia coli, Veillonella Gram-positive: Brucella, Enterococcus (for example, vancomycin-resistant Enterococcus), Staphylococcus spp. (for example, methicillin-resistant Staphylococcus aureus (...) infectious diseases physician, given the high risk of graft loss and mortality in case of transmission of infection to the recipient [198]. Turning to fungal infections, the most commonly transmitted from donors to recipients include Candida species, endemic mycoses (particularly Coccidioides immitis), and Cryptococcus. When transmitted, these mycoses are associated with signi?cant morbidityinadditiontofrequentgraftand/orrecipientloss.Con- tamination of the organ during procurement and preservation

2015 European Association for the Study of the Liver

163. A case report of sinusoidal diffuse large B-cell lymphoma in a STK4 deficient patient. Full Text available with Trip Pro

infections, mucocutaneous candidiasis, cutaneous warts, skin abscesses, T- and B-cell lymphopenia, and neutropenia.In this study we describe the infrequent incidence and successful treatment of sinusoidal diffuse large B-cell lymphoma in a STK4 deficient patient with clinical manifestation of severe intractable headaches, unilateral swelling of her face, nasal congestion, stuffiness, and pain in maxillary.Clinical data including headaches, unilateral swelling of face, nasal congestion, stuffiness

2020 Medicine

164. Kaposi Sarcoma Treatment (PDQ®): Health Professional Version

an opportunistic infection. The sites of disease at presentation of epidemic KS are much more varied than the sites seen in other types of this neoplasm. While most patients present with skin disease, KS involvement of lymph nodes or the gastrointestinal tract may occasionally precede the appearance of the cutaneous lesions. The disease often progresses in an orderly fashion from a few localized or widespread mucocutaneous lesions to more numerous lesions and generalized skin disease with lymph node (...) Extensive oral KS Gastrointestinal KS KS in other non-nodal viscera Immune system (I) CD4 cells ≥ 200/µL CD4 cells <200 per cubic mm Systemic illness (S) No history of OIs or thrush[ Note: OIs are opportunistic infections. ] History of OIs and/or thrush No “B” symptoms[ Note: “B” symptoms are unexplained fever, night sweats, >10% involuntary weight loss, or diarrhea persisting >2 weeks. ] “B” symptoms present Performance status ≥70 (Karnofsky) Performance status <70 Other HIV-related illness (e.g

2018 PDQ - NCI's Comprehensive Cancer Database

165. Fungal skin infection - foot

on and for more information. Candida skin infection — may cause interdigital erythema, scaling, and maceration. See the CKS topic on for more information. Basis for recommendation Basis for recommendation The information on the differential diagnosis of fungal foot infection is based on expert opinion in a review article on fungal foot infection [ ] and on fungal infections [ ; ]. Management Management : covers the management of people with suspected fungal foot infection. Scenario: Management Scenario

2018 NICE Clinical Knowledge Summaries

166. Balanitis

by the build up of smegma pearls (which form when foreskin adhesions break down). This predisposes to colonization with a mixture of organisms ( Candida albicans being most commonly isolated). This typically presents with redness on the undersurface of the glans penis, with sparing around the urethral meatus. There may be small, eroded itchy papules on the glans, shaft of the penis, and scrotal skin, with a white curd-like discharge. Other organisms such as group A beta-haemolytic streptococci (...) the penile skin, genital area, and extra-genital skin for clinical features suggesting an underlying cause. Considering a sub-preputial swab for Candida sp. and bacterial culture and sensitivity if symptoms are severe (suggesting a secondary infection). Screening for an STI if there is a high risk or suspected infection. Screening for underlying diabetes mellitus and HIV (if appropriate), if balanitis is severe. Management of a person with balanitis involves: Advising the person to clean the penis

2018 NICE Clinical Knowledge Summaries

167. Bacterial vaginosis

Discharge: Quick Reference Guide for Primary Care published by Public Health England (PHE) [ ]. Taking a history Expert opinion in the RCGP/BASHH guideline is that a careful clinical and sexual history is essential when managing a woman with vaginal discharge because [ ]: Bacterial vaginosis (BV) is often under-diagnosed (even though it is more common than candida). Candida is often over-diagnosed (by women and clinicians). Sexually transmitted infections (STIs) may be missed if a sensitive sexual (...) . The characteristic appearance of the discharge is not specific for BV but supports the diagnosis. If the appearance of the discharge is not characteristic, consider , such as trichomoniasis or candidiasis. BV is not usually associated with soreness, itching, or irritation. If these symptoms are present, consider or co-infection with candidiasis or trichomoniasis. See the CKS topics on and for more information. Test the pH of the vaginal discharge to help distinguish between BV and other causes for symptoms

2018 NICE Clinical Knowledge Summaries

168. Dyspepsia - proven functional

. The content has been amended to include second-line drug regimens for Helicobacter pylori eradication, in line with the updated NICE guidance. The prescribing information section has been expanded to include antibiotics recommended for H. pylori eradication. The topic has also undergone significant restructuring. Previous changes Previous changes December 2016 — minor update. Subacute cutaneous lupus erythematosus has been added as a very infrequent adverse effect of proton pump inhibitors, in line (...) inhibitors (PPIs) are usually mild and reversible. Adverse effects include headache, diarrhoea, nausea, vomiting, abdominal pain, constipation, and dizziness. Less common adverse effects include dry mouth, peripheral oedema, sleep disturbance, fatigue, paraesthesia, arthralgia, myalgia, pruritus, and rash. Rare or very rare adverse effects include: Subacute cutaneous lupus erythematosus (SCLE), which can occur weeks, months, or years after exposure to a PPI. If suspected discontinue the PPI and seek

2018 NICE Clinical Knowledge Summaries

169. Impetigo

[ ; ; ; ; ]. Differential diagnosis What else might it be? Skin infections and infestations Bacterial skin infections such as cellulitis, ecthyma, erysipelas, staphylococcal scaled skin syndrome, and necrotizing fasciitis. For more information, see the CKS topic on . Fungal skin infections such as candidiasis, tinea corporis or tinea capitis. For more information, see the CKS topics on , , and . Parasitic infestations such as scabies. For more information, see the CKS topic on . Viral infections such as varicella (...) is negligible. Topical fusidic acid can be used during breastfeeding, but it should not be applied on the breast. A few cases of serious cutaneous reactions (e.g. DRESS syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome) have been reported with systemic sodium fusidate, usually appearing in the first weeks of treatment. [ ; ] Flucloxacillin Flucloxacillin Contraindications and cautions What are the contraindications and cautions for flucloxacillin? Do not prescribe flucloxacillin to people

2018 NICE Clinical Knowledge Summaries

170. Dyspepsia - proven peptic ulcer

— minor update. Subacute cutaneous lupus erythematosus has been added as a very infrequent adverse effect of proton pump inhibitors, in line with a Medicines and Healthcare products Regulatory Agency (MHRA) Drug Safety Update (2015). July 2015 — minor update. The prescribing information section for clarithromycin has been re-written for clarity. February 2015 — minor update. The prescribing information section was updated to provide additional information regarding the possible drug interaction

2018 NICE Clinical Knowledge Summaries

171. Dyspepsia - unidentified cause

with the updated NICE guidance. The prescribing information section has been expanded to include antibiotics recommended for H. pylori eradication. The topic has also undergone significant restructuring. Previous changes Previous changes December 2016 — minor update. minor update. Subacute cutaneous lupus erythematosus has been added as a very infrequent adverse effect of proton pump inhibitors, in line with a Medicines and Healthcare products Regulatory Agency (MHRA) Drug Safety Update (2015). July 2015

2018 NICE Clinical Knowledge Summaries

172. Rosacea - acne

, central face papules or pustules, or both. Phymatous rosacea, where thickening of the skin is seen with irregular surface nodularities, and enlargement. This may occur on the nose (rhinophyma), chin, forehead, cheeks or ears. Ocular rosacea, including inflammation of different parts of the eye and eyelid, which is usually bilateral. Granulomatous rosacea (a rare variant type of acne rosacea), which is non-inflammatory and characterised by hard, brown, yellow, or red cutaneous papules, or nodules (...) % for vehicle gel at day 29 (P<0.001). [ ]. Diffuse central facial erythema is often present, even in people who are not experiencing acute flare-ups of acne rosacea. The α-adrenergic agonist brimonidine has demonstrated vasoconstrictive and vasostabilising properties, as it targets α-adrenoreceptors in the smooth muscle sheath around the cutaneous blood vessels. However, brimonidine has no effect on capillaries and telangiectasia, which do not contain a smooth muscle layer [ ]. Brimonidine gel

2018 NICE Clinical Knowledge Summaries

173. Palliative care - oral

are comatose, are enterally or parenterally fed, or have trismus). Systemic factors: Diabetes. Immunosuppression. Drug use (for example corticosteroids). Malnutrition. The prevalence of oral yeast carriage is higher in people with cancer than in healthy adults. This is a possible risk factor for oral candidiasis: The prevalence of Candida albicans in the mouths of healthy adults is 29–50%: A study that assessed the prevalence of oral candida in terminally ill people (n = 140) found that 112 (80%) had (...) required. Tests which should be considered include: Full blood count if neutropenia is suspected. Platelet count if spontaneous bleeding accompanies chemotherapy-induced mucositis. Iron, folate, and vitamin B12 levels if there is recurrent aphthous ulceration. A swab to check for candida infection if clinical features are suggestive. If there is persistent or recurrent oral candidiasis species typing and sensitivity testing may be helpful. Advice should be offered on measures to prevent oral problems

2018 NICE Clinical Knowledge Summaries

174. Fungal skin infection - body and groin

pitting. See the CKS topic on for more information. Granuloma annulare — single or multiple rings of small, smooth, red or flesh-coloured papules; no scale, may be vesicles or pustules. Often on the dorsum of the hands or feet. Erythema multiforme — acute-onset target lesions with no scale; may be associated with oral lesions. Subacute cutaneous lupus — multiple annular lesions, typically on sun-exposed areas. Other conditions that may present similarly to fungal infection of the groin include (...) of fungal skin infections of the body and groin. Search dates July 2013 - March 2018 Key search terms Various combinations of searches were carried out. The terms listed below are the core search terms that were used for EBSCO Medline. (MH "Dermatomycoses+") AB ( ((fungal* or mould* or mold or molds or candida* or tinea or trichophyton* or dermatophyt* or myco* or dermatomyco*) N3 (skin or body or groin or dermat* or corporis or cruris)) ) OR AB ( ((fungal* or mould* or mold or molds or candida

2018 NICE Clinical Knowledge Summaries

175. Management of Nasopharyngeal Carcinoma

in the treatment of NPC. Other late toxicities post-radiotherapy are listed in Appendix 8. 8.1 Oral Complications The common oral complications post-radiotherapy are: • xerostomia (80% to 100%) 55-57, level II-3 • mucositis (60% from third to fourth week after the beginning of radiotherapy) 55, level II-3 • candidiasis (16% to 67%) 55-57, level II-3 It is essential that NPC patients receive dental assessment prior to radiotherapy to minimise post-treatment oral complications. The oral complications among NPC

2016 Ministry of Health, Malaysia

176. Acne clinical guideline Full Text available with Trip Pro

, J., Fung, K. et al. Development and validation of a comprehensive acne severity scale. J Cutan Med Surg . 2007 ; 11 : 211–216 | | | , x 9 Mallon, E., Newton, J.N., Klassen, A. et al. The quality of life in acne: a comparison with general medical conditions using generic questionnaires. Br J Dermatol . 1999 ; 140 : 672–676 | | | , x 10 Gupta, M.A., Johnson, A.M., and Gupta, A.K. The development of an Acne Quality of Life scale: reliability, validity, and relation to subjective acne severity (...) and global assessments. J Cutan Med Surg . 2006 ; 10 : 160–165 | | | , x 28 Bergman, H., Tsai, K.Y., Seo, S.J., Kvedar, J.C., and Watson, A.J. Remote assessment of acne: the use of acne grading tools to evaluate digital skin images. Telemed J E Health . 2009 ; 15 : 426–430 | | | , x 29 Min, S., Kong, H.J., Yoon, C., Kim, H.C., and Suh, D.H. Development and evaluation of an automatic acne lesion detection program using digital image processing. Skin Res Technol . 2013 ; 19 : e423–e432 | , x 30 Qureshi

2016 American Academy of Dermatology

177. Persistent Pain with Breastfeeding

that are thought to predispose a woman to develop Candida infection include the following: - A predisposition to Candida infections - Thrush in the infant’s mouth or in the diaper (nappy) area (monilial rash) - Recent use of antibiotics in mother or child Table 1. (Continued) Condition Symptoms/signs Management Herpes zoster Pain and vesicular rash following a dermatome Oral antiviral therapy such as acyclovir or valacyclovir should be used in doses recommended for treating Herpes zoster Avoid breastfeeding (...) ?lms: A roleinrecurrentmastitisinfections?VetJ2006;171:398–407. 26. Harriott MM, Noverr MC. Candida albicans and Staphy- lococcus aureus form polymicrobial bio?lms: Effects on antimicrobial resistance. Antimicrob Agents Chemother 2009;53:3914–3922. ABM PROTOCOL 7 27. AdamB,BaillieGS,DouglasLJ.Mixedspeciesbio?lmsof Candida albicans and Staphylococcus epidermidis. J Med Microbiol 2002;51:344–349. 28. Proctor RA, von Eiff C, Kahl BC, et al. Small colony vari

2016 Academy of Breastfeeding Medicine

178. Practice Guidelines for the Diagnosis and Management of Aspergillosis Full Text available with Trip Pro

recommendation; low-quality evidence) . 35. Recombinant interferon-γ is recommended as prophylaxis in CGD patients (strong recommendation; high-quality evidence). Its benefit as adjunctive therapy for IA is unknown. 36. Surgery for aspergillosis should be considered for localized disease that is easily accessible to debridement (eg, invasive fungal sinusitis or localized cutaneous disease) (strong recommendation; low-quality evidence). The benefit for IA in other settings such as in the treatment (...) therapy should be considered ( strong recommendation; low-quality evidence ). What Are the Treatment Recommendations for Aspergillus Osteomyelitis and Septic Arthritis? Recommendation 54. Surgical intervention is recommended, where feasible, for management of Aspergillus osteomyelitis and arthritis, combined with voriconazole ( strong recommendation; moderate-quality evidence ). What Are the Treatment Recommendations for Cutaneous Aspergillosis? Recommendations 55. As cutaneous lesions may reflect

2016 Infectious Diseases Society of America

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