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Cutaneous Candidiasis

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141. Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency (PubMed)

Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency Chronic mucocutaneous candidiasis (CMC) is defined as recurrent or persistent infection of the skin, nails, and/or mucosae with commensal Candida species. The first genetic etiology of isolated CMC-autosomal recessive (AR) IL-17 receptor A (IL-17RA) deficiency-was reported in 2011, in a single patient. We report here 21 patients with complete AR IL-17RA deficiency (...) is, thus, essential for mucocutaneous immunity to Candida and Staphylococcus, but otherwise largely redundant. A diagnosis of AR IL-17RA deficiency should be considered in children or adults with CMC, cutaneous staphylococcal disease, or both, even if IL-17RA is detected on the cell surface.

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2016 Proceedings of the National Academy of Sciences of the United States of America

142. Immune reconstitution inflammatory syndrome associated with dermatophytoses in two HIV-1 positive patients in rural Tanzania: a case report. (PubMed)

Immune reconstitution inflammatory syndrome associated with dermatophytoses in two HIV-1 positive patients in rural Tanzania: a case report. Immune reconstitution inflammatory syndrome associated with dermatophytoses (tinea-IRIS) may cause considerable morbidity. Yet, it has been scarcely reported and is rarely considered in the differential diagnosis of HIV associated cutaneous lesions in Africa. If identified, it responds well to antifungals combined with steroids. We present two cases (...) lesions on the face, trunk and lower limbs. Tinea-IRIS was suspected and fluconazole (150 mg daily) and prednisolone (1 mg/Kg/day tapered down after 1 week) were given. Her symptoms subsided completely after 8 weeks of treatment, and her next CD4 counts had increased to 134 cells/μL (11 %). The second case was a 35 years-old female newly diagnosed with HIV. She had 1 CD4 cell/μL (0 %), haemoglobin 9.8 g/dl, and normal renal and liver function tests. Esophageal candidiasis and normocytic-normochromic

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2016 BMC Infectious Diseases

143. Novel Use of Terpenoids for Treatment of Dermatologic Diseases: A Systematic Review of Clinical Trials. (PubMed)

. References were manually reviewed for potentially relevant studies.The search yielded 437 unique abstracts, of which 13 met inclusion and exclusion criteria. High-quality evidence suggests that ingenol mebutate may be effective in treating actinic keratosis. Limited available evidence indicates that terpenoids may benefit patients with nonmelanoma skin cancers, cutaneous candidiasis, hyperpigmentation, photoaging, and wounds.Terpenoids appear to be effective in treating specific dermatologic conditions (...) Novel Use of Terpenoids for Treatment of Dermatologic Diseases: A Systematic Review of Clinical Trials. Terpenoids demonstrate pharmacologic activities that address important mechanisms underlying the pathogenesis of several cutaneous diseases. This review evaluated clinical trials of dermatology-specific terpenoid-based treatments.PubMed and EMBASE were reviewed on July 8, 2014. Two independent reviewers reviewed studies for inclusion and extracted data for studies meeting eligibility criteria

2015 Journal of alternative and complementary medicine (New York, N.Y.)

144. Cresemba - isavuconazole

patients RMP Risk Management Plan SAE serious adverse event SBECD sulfobutyl ether beta-cyclodextrin sodium SCAR severe cutaneous adverse reactions s.d. (SD) standard deviation SFU short-term follow-up visit SOC System Organ Class ss steady state t1/2 half-life tmax time of observed maximal plasma concentration t > MIC time-dependent attainment of free drug concentrations above the MIC TOC Test-of-cure visit TEAE treatment-emergent adverse event UDP uridine diphosphate UGT uridine diphosphate (...) immunosuppressive agents—including oral or intravenous steroids and tumor necrosis factor (TNF)– alpha blockers—are at risk. In addition, hematologic cancer patients with opportunistic herpetic infections (e.g., cytomegalovirus) and graft versus host disease are at increased risk. Most mucormycosis infections are life-threatening. Severe infection of the facial sinuses, which may extend into the brain, is the most common presentation. Pulmonary, cutaneous, and gastrointestinal (GI) infections Assessment report

2015 European Medicines Agency - EPARs

145. Secukinumab (Cosentyx)

tissue disorders (11.4%, 11.8% and10.8% vs. 5.5%). Notable differences between the rates seen for 300 mg and 150 mg doses were primarily for preferred terms in the infections and infestations SOC which showed: ? 5 to 6 fold increases for 300 mg for erysipelas, bacterial pharyngitis, bacterial infection ? 2 to 3 fold increases for 300 mg urinary tract infections, bacterial sinusitis, otitis media/ otitis media bacterial, bacterial skin infections, impetigo, oral candidiasis, vulvovaginal candidiasis (...) defects affecting the Th17 pathway and in individuals who have genetic defects in IL-17 signaling suggest that blockade of IL-17 increases the risk for fungal infections, particularly mucocutaneous candidiasis, as well as staphylococcal skin infections. These adverse events as well as some others related to infections demonstrated a dose-response event rate as shown in the table below. Table 24 : Adverse Events related to infections reported in psoriasis studies which show a dose-response Adverse

2014 FDA - Drug Approval Package

146. Isavuconazonium sulfate (BAL8557) (Cresemba)

: Patient with Incorrect Drug Administration, Trial 9766-CL-0104 21 Table 6: Patients Who Received an Excluded Concomitant Medication 22 Table 7: Sites Selected for GCP Inspections 23 Table 8: Summary of Phase 3 Trials 27 Table 9: Summary of Phase 2 Trials 28 Table 10: Summary of Phase 1 Studies 30 Table 11: Phase 2 Study 9766-CL-0101/ WSA-CS-001: Results Summary of Treatment of Esophageal Candidiasis 43 Table 12: Phase 2 Study 9766-CL-0102/WSA-CS-002: Results Summary of Prophylaxis in Neutropenic AML

2014 FDA - Drug Approval Package

147. DuoResp Spiromax - budesonide / formoterol

of the 1 µg/kg acute dose but not the 10 µg/kg acute dose. These results suggested that tolerance to the anti-leakage effect of formoterol could occur with repeated higher doses (Bowden, 1997). The effects of formoterol on rat and guinea pig hypersensitivity reactions and on mouse IgE antibody formation were investigated. The inhibitory effect of intravenously and orally administered formoterol on (mouse) IgE-mediated 24-hour passive cutaneous anaphylaxis (PCA) in rats was 6.3 and 33 times

2014 European Medicines Agency - EPARs

148. BiResp Spiromax (budesonide / formoterol fumarate dihydrate)

the effectiveness of the 1 µg/kg acute dose but not the 10 µg/kg acute dose. These results suggested that tolerance to the anti-leakage effect of formoterol could occur with repeated higher doses (Bowden, 1997). The effects of formoterol on rat and guinea pig hypersensitivity reactions and on mouse IgE antibody formation were investigated. The inhibitory effect of intravenously and orally administered formoterol on (mouse) IgE-mediated 24-hour passive cutaneous anaphylaxis (PCA) in rats was 6.3 and 33 times

2014 European Medicines Agency - EPARs

149. Clinical Practice Guideline for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer

as the presence of deep tissue infection, endocarditis, septic thrombosis (A-II) or persistent bacteremia or fungemia occurring >72 h after catheter removal in a patient who has received appropriate antimicrobials ( A-II for S. aureus , C-III for other pathogens). 47. Hand hygiene, maximal sterile barrier precautions, and cutaneous antisepsis with chlorhexidine during CVC insertion are recommended for all CVC insertions (A-I). XII. What Environmental Precautions Should be Taken When Managing Febrile (...) the bloodstream. Deep-tissue candidiasis, such as hepatic or hepatosplenic disease, esophagitis, or endocarditis, is much less common. Molds, such as Aspergillus , are most likely to cause life-threatening infection of the sinuses and lungs, typically after ≥2 weeks of neutropenia. The majority of patients who develop fever during neutropenia have no identifiable site of infection and no positive culture results. Nonetheless, the Panel recommends that every patient with fever and neutropenia receive empirical

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2010 Infectious Diseases Society of America

150. British Association of Dermatologists' guidelines on the efficacy and use of acitretin in dermatology

studies with 58 patients with oral LP trea- ted with etretinate (mostly poor-quality studies), and one crossover RCT with 28 patients which showed signi?cant improvement with etretinate over placebo. Etretinate was the favoured retinoid therapy. The authors recommend acitretin as ?rst-line therapy in cutaneous LP and give further anecdotal evidence. Acitretin may also be preferred in the hyperkeratotic variant of LP for its modulating effect on keratinization. Lupus erythematosus In an RCT of 58 (...) , and ?ve of six patients with subacute cutaneous lupus erythematosus showed complete clearing of their lesions within 2–4 weeks. As in LP, a verrucous variant is seen where the modulation of hyperker- atosis may be an advantage favouring acitretin. Lichen sclerosus One RCT randomized 78 patients but only measured ef?cacy per protocol in 46 subjects. A total of 14 of 22 patients on acitretin responded compared with six of 24 in the placebo group. 77 However, due to the high drop-out rate the study has

2010 British Association of Dermatologists

151. Evaluating the Safety and Tolerability of Ruxolitinib in Antiretroviral-Treated HIV-Infected Adults

HIV encephalopathy, HIV wasting, esophageal candidiasis, or pneumocystis pneumonia without dissemination. NOTE B: List available: http://www.cdc.gov/mmwr/preview/mmwrhtml/00018871.htm Herpes zoster (dermatomal or non-dermatomal). NOTE C: A history of prior chickenpox is not exclusionary. Lymphoproliferative malignancy Chronic liver disease of any etiology and any degree of severity Chronic hepatitis, except for hepatitis C that has been cured (defined as a Sustained Virologic Response, which (...) is an undetectable HCV-RNA at 12 weeks or more after completing treatment measured by a sensitive, qualitative, or quantitative HCV-RNA assay) Disseminated fungal infection of any type or duration that is not limited to cutaneous or mucocutaneous surfaces A medical disorder that predisposes to bleeding *NOTE: If a site investigator is unsure of whether a history of a significant medical or psychiatric condition should lead to participant exclusion, the investigator should err on the side of safety if s/he

2015 Clinical Trials

155. Frequency, pattern, and extent of skin diseases in relation to CD4+ cell count among adults with human immunodeficiency virus infection or acquired immunodeficiency syndrome in Osogbo, southwestern Nigeria. (PubMed)

. Intensity of pain was graded for specific conditions such as herpes zoster. Chi-squared statistics and Pearson correlations were determined.Mean±standard deviation age was 35.04±8.83 years in the patient group and 32.21±8.30 years in the control group. The prevalences and patterns of skin diseases in HIV/AIDS patients were similar to those reported in previous studies. Most commonly found dermatoses were oral candidiasis (n=28, 20.0%), pruritic papular eruption (n=27, 19.3%), xeroderma (n=23, 16.4 (...) %), dermatophytosis (n=22, 15.7%), and fluffy hair (n=19, 13.6%). The presence of specific skin lesions represented a better correlate with immunosuppression than cutaneous extents. However, the extents of viral warts and multiple blue–black nails correlated significantly with CD4+ cell count. The presence of a lighter hair color phenotype signifies a lower CD4+ cell count than a softer hair phenotype.The presence of specific skin lesions correlates more strongly with a low CD4+ cell count than does the extent

2014 International Journal of Dermatology

156. Switch From Nevirapine-based Regimen to Once a Day Rilpivirine/Emtricitabine/Tenofovir

illness requiring systemic treatment and/or hospitalization until candidate either completes therapy or is clinically stable on therapy, in the opinion of the site investigator, for at least 14 days prior to study entry. NOTE: Isolated cutaneous Kaposi's Sarcoma, oral candidiasis, vaginal candidiasis, mucocutaneous herpes simplex, and other non-serious illnesses (as judged by the site investigator) have no restriction. Known allergy/sensitivity to study drugs or their formulations. Active drug

2014 Clinical Trials

157. Oral Complications of Chemotherapy and Head/Neck Radiation

-up = 0.7% Epidemiological studies = 1.2% Dysgeusia [ ] CT only = 56.3% (mean) RT only = 66.5% (mean) Combined CT and RT = 76% (mean) Oral fungal infection [ ] Of clinical oral fungal infection (all oral candidiasis): Pretreatment = 7.5% During treatment = 39.1% Posttreatment = 32.6% Of oral candidiasis clinical infection by cancer treatment: During HNC RT = 37.4% During CT = 38% Oral viral infection [ ] In patients treated with CT for hematologic malignancies: Patients with oral ulcerations (...) mucositis. Infection: Fungal. Bacterial. Salivary gland dysfunction: Sialadenitis. Xerostomia. Taste dysfunction. Chronic complications: Mucosal fibrosis and atrophy. Xerostomia. Dental caries. Soft tissue necrosis. Osteonecrosis. Taste dysfunction: Dysgeusia. Ageusia. Muscular/cutaneous fibrosis. Infections: Fungal. Bacterial. Unlike chemotherapy, however, radiation damage is anatomically site-specific; toxicity is localized to irradiated tissue volumes. Degree of damage depends on treatment regimen

2012 PDQ - NCI's Comprehensive Cancer Database

159. Paronychia (Overview)

housekeepers, dishwashers, bartenders, florists, bakers, and swimmers. In addition, individuals who are immunocompromised, such as those with human immunodeficiency virus (HIV) infection or those undergoing steroid therapy, are predisposed to paronychia. Other conditions associated with abnormalities of the nail fold that predispose individuals to chronic paronychia include psoriasis, mucocutaneous candidiasis, and drug toxicity from medications such as retinoids, epidermal growth factor receptor (...) and Drug Concentrations of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors. Oncology . 2018. 95 (4):251-256. . Hamid RN, Ahn CS, Huang WW. Adverse Cutaneous Effects of Neratinib. J Dermatolog Treat . 2018 Oct 15. 1-8. . Tomková H, Kohoutek M, Zábojníková M, Pospísková M, Ostrízková L, Gharibyar M. Cetuximab-induced cutaneous toxicity. J Eur Acad Dermatol Venereol . 2010 Jun. 24(6):692-6. . Coquart N, Karam A, Metges JP, Misery L. [Topical steroids in the treatment of paronychia induced

2014 eMedicine.com

160. Noncandidal Fungal Infections of the Mouth (Overview)

== processing > Noncandidal Fungal Infections of the Mouth Updated: Mar 01, 2018 Author: Manuel Valdebran, MD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Noncandidal Fungal Infections of the Mouth Overview Background This article focuses on noncandidal oral fungal infections (deep mycoses). Candidiasis (candidosis) is by far the most common fungal infection of the mouth (oral cavity). Other Medscape articles on candidiasis include , and This article discusses (...) the following noncandidal oral mycoses: aspergillosis, cryptococcosis, histoplasmosis, blastomycosis, paracoccidioidomycosis, zygomycosis (mucormycosis), oral geotrichosis, Rhodotorula infection, and fusariosis. Although these noncandidal fungal infections are considerably less common than oral candidiasis, they commonly produce subclinical infection, especially pulmonary infections. Immunocompromised persons are at particular risk from these mycoses, and clinical manifestations of infection

2014 eMedicine.com

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