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Cutaneous Candidiasis

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121. Topical Photodynamic therapy

direct evidence of prevention of invasive SCC remains limited. PDT has also been studied for its place in the treatment as well as potential to prevent, superficial skin cancers in immune-suppressed patients, although sustained clearance rates are lower than when used in immune-competent individuals. Additional potential cancer indications for topical PDT have been explored including local patch/plaque cutanous T-cell lymphoma (CTCL). In addition, PDT can improve acne and several other inflammatory (...) % of respondents indicating a very favourable impression of the treatment, although with burning sensation described in 21%. 122 A national audit of use of PDT in clinical practice in Scotland confirmed that 27% of all use was for patients with Bowen’s, just behind use for sBCC (33%) and AK (35%). 123 Invasive squamous cell carcinoma SCC (Strength of Recommendation D, Quality of Evidence 11-iii) There remains limited data on the efficacy of topical PDT for primary cutaneous invasive SCC although MAL-PDT can

2019 European Dermatology Forum

126. Nappy rash

by a nappy. It is primarily an irritant contact dermatitis. The main irritants are urine, faeces, and faecal enzymes, which lead to skin breakdown, typically of the perineum and convex surfaces of the buttocks, with sparing of the skin folds. History and exam presence of risk factors acute onset of rash in nappy area erythema of convex surfaces in nappy area sparing of skin folds features of candidiasis features of Staphylococcus aureus infection features of group A Streptococcus infection fussiness (...) Virginia University School of Medicine Morgantown WV Disclosures LSN is an author of references cited in this topic. Professor of Pediatrics Vice Chair for Education Department of Pediatrics Wayne State University School of Medicine Designated Institutional Official Children's Hospital of Michigan Detroit MI Disclosures DK is an author of references cited in this topic. Peer reviewers Assistant Professor of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL

2017 BMJ Best Practice

127. Angular cheilitis

/15865910?tool=bestpractice.com The cause is usually multi-factorial, due either to a primary infection or to a non-infectious entity such as mechanical irritation, nutritional deficiency, or other dermatological condition. Rogers RS III, Bekic M. Diseases of the lips. Semin Cutan Med Surg. 1997 Dec;16(4):328-36. http://www.ncbi.nlm.nih.gov/pubmed/9421227?tool=bestpractice.com [Figure caption and citation for the preceding image starts]: Angular cheilitis From the collection of Dr Wanda C. Gonsalves (...) ; patient consent obtained [Citation ends]. [Figure caption and citation for the preceding image starts]: Angular cheilitis From the collection of Dr Wanda C. Gonsalves; patient consent obtained [Citation ends]. History and exam presence of risk factors dentures with palatal erythema oral candidiasis pruritus painful red fissures eczematous dermatitis of lower face specific medicines hx of inflammatory bowel disease hx of acid reflux hx of total parenteral nutrition hx of eating disorders alopecia

2017 BMJ Best Practice

128. Interventions for the prevention of recurrent erysipelas and cellulitis. (Full text)

= 0.47, with certainty of evidence rated low for these outcomes. The existing data did not allow us to fully explore its impact on length of hospital stay.The common adverse reactions were gastrointestinal symptoms, mainly nausea and diarrhoea; rash (severe cutaneous adverse reactions were not reported); and thrush. Three studies reported adverse effects that led to discontinuation of the assigned therapy. In one study (erythromycin), three participants reported abdominal pain and nausea, so

2017 Cochrane PubMed abstract

129. Guidelines for the Management of Genital, Anal and Throat HPV Infection in New Zealand

, oropharynx, vagina, vulva and penis. There are more than 100 types of HPV, which may be subdivided into either cutaneous or mucosal categories depending on their tissue preference. There are more than 40 types which infect the anogenital and oropharyngeal mucosa. These can be broadly split into “high-risk” and “low-risk” types based on their association with the development of malignancy. • Low-risk HPV (lrHPV) – HPV 6 and HPV 11 cause approximately 90% of genital warts and are only rarely associated (...) minutes prior to micturition and defaecation. • A concomitant thrush infection is common. Local imidazole preparations often help, and/or oral fluconazole. • For large areas made raw by wart ablations, 1% silver sulphadiazine cream is useful. Table 1: Treatment by site (For details of individual therapies, see Table 2, page 12) Site Treatment Use in Pregnancy External genital warts Patient-applied Imiquimod (Aldara 5% cream); OR Podophyllotoxin solution. Provider-administered Cryotherapy

2017 New Zealand Sexual Health Society

130. Guidelines for the Management of Genital Herpes in New Zealand

. (HSV infection can cause this condition.) • Autoimmune blistering disorders such as pemphigus and cicatrical pemphigoid, which are chronic. • Other genital infections lack the preceding vesicular stage, apart from varicella zoster infection which is unilateral. • Candidiasis and folliculitis produce pustules, which must be differentiated from HSV infection.12 Management of First Episode of Genital Herpes Patient presents with first episode of genital herpes Check symptom history, examine and take (...) of determining that the patient has a recurrent episode, but other genital conditions may mimic and/or coexist with recurrent herpes, and careful examination of the genitalia should always form part of the diagnostic procedure. • Common differential diagnoses include lichen sclerosus, fissuring due to candidiasis, folliculitis, bacterial skin infections, dermatitis and any other skin conditions that cause itching and fragility of the skin. • Uncommon conditions include erythemea multiforme, hidradenitis

2017 New Zealand Sexual Health Society

131. Scleroderma Morphea

Clinical scores 14 Radiologic examination 15 Technical outcome measures 16 Differential diagnoses 16 Specifics of juvenile localized scleroderma 16 Treatment 17 Topical therapy 18 Systemic therapy 19 UV phototherapy 21 Physiotherapy 23 Surgical therapy 23 References 29 II Scleromyxedema 38 Introduction 38 Epidemiology 38 Pathogenesis 38 Clinical manifestation 38 Cutaneous manifestations 39 Extracutaneous manifestations 39 Associated disorders 41 Clinical course 41 Diagnostic procedures 42 (...) Azathioprine 103 Cyclophosphamide 103 Bioimmunomodulatory agents 104 Therapeutic approaches 104 Systemic sclerosis and myositis 104 Systemic sclerosis and rheumatoid arthritis 104 Systemic sclerosis and systemic lupus erythematosus 105 Mixed connective tissue disease 105 Systemic sclerosis and Sjögren’s overlap syndrome 105 References 111 VI Scleredema 115 Introduction 115 Epidemiology 115 Pathogenesis 116 Clinical manifestations 116 Cutaneous manifestations 116 Extracutaneous manifestations 116 Associated

2018 European Dermatology Forum

132. Lichen Planus

Paraneoplastic pemphigus, candidiasis, lupus erythematosus, secondary syphilis, leukokeratosis, traumatic patches, cicatricial pemphigoid CLINICAL VARIANTS OF LICHEN PLANUS Several variations have been described, according to 1) the distribution and configuration of lesions, 2) the morphology of an individual lesion, and/or 3) the site of involvement. The various clinical forms were divided into three general categories, namely cutaneous, appendageal and mucosal lichen planus. The specific clinical (...) to C. albicans and to the exogenous mutagens found in tobacco and alcohol. 17 • In patients with oral lichen planus, the chronic inflammatory response and simultaneous healing response of epithelial wounds may increase the likelihood of cancer-forming gene mutations. Case reports of SCC emerging from hypertrophic cutaneous LP lesions or chronic anogenital or esophageal lesions have been described. 3 Persistent ulcers/lesions should undergo biopsy, particularly when resistant to therapy. Systemic

2018 European Dermatology Forum

135. Targeted Immunomodulators for the Treatment of Moderate-to-Severe Plaque Psoriasis: Effectiveness and Value

80% to 90% of all patients with psoriasis. 5-7 Other types of cutaneous psoriasis include inverse psoriasis (affecting the skin folds, particularly the genital area), guttate psoriasis (small spots all over the body), palmar-plantar psoriasis (on the hands and feet), nail psoriasis, erythrodermic psoriasis (where the entire body may turn red), and pustular psoriasis (sterile pustules). 1,8,48 . These other types of cutaneous psoriasis, accompanying plaque psoriasis in up to 40% of patients

2018 California Technology Assessment Forum

137. CRACKCast Episode 183 – The Immunocompromised Patient

, such as cytomegalovirus, herpes simplex, and varicella-zoster, fungal infections with Candida, Cryptococcus, Mucor, Aspergillus, and Pneumocystis protozoa such as Toxoplasma gondii. Some infections are seen only below a certain CD4 cell count. Pneumocystis pneumonia Eg only seen w/ counts below 200 cells/mL (2 × 105 cells/L), toxoplasmosis or cryptococcal meningitis = counts below 100 cells/mL (1 × 105 cells/L) NK cells, closely related to lymphocytes but neither B nor T cells important in the innate immune response (...) neoformans Histoplasma capsulatum Coccidioides immitis Candida sp. Aspergillus sp. Pneumocystis jiroveci (formerly carinii) Viruses Herpes simplex Varicella zoster Cytomegalovirus Epstein-Barr Less common: Measles, adenovirus Parasites Toxoplasma gondii Cryptosporidium sp. Strongyloides stercoralis 3) What disease states produce impaired humoral / B-cell immunity? What are the most common bacteria? Inherited complement deficiencies = frequent and recurrent infections The risk of meningococcal infection

2018 CandiEM

139. Targeted Immunomodulators for the Treatment of Moderate-to-Severe Plaque Psoriasis: Effectiveness and Value

It is associated with systemic diseases including other autoimmune diseases (e.g., inflammatory bowel disease), metabolic syndrome, and cardiovascular disease. 12,13 In addition, up to 30% of patients with plaque psoriasis have at least some manifestations of psoriatic arthritis, 9-11 and may reach up to 40% among patients treated with biologics. 9,47 Plaque psoriasis accounts for about 80% to 90% of all patients with psoriasis. 5-7 Other types of cutaneous psoriasis include inverse psoriasis (affecting (...) the skin folds, particularly the genital area), guttate psoriasis (small spots all over the body), palmar-plantar psoriasis (on the hands and feet), nail psoriasis, erythrodermic psoriasis (where the entire body may turn red), and pustular psoriasis (sterile pustules). 1,8,48 . These other types of cutaneous psoriasis, accompanying plaque psoriasis in up to 40% of patients, are often hard to treat and have an important impact on their quality of life 49 . Roughly 70% to 80% of patients with plaque

2018 California Technology Assessment Forum

140. A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology (Full text)

of historically fastidious organisms such as HACEK [ ] ( Haemophilus , Aggregatibacter , Cardiobacterium , Eikenella , and Kingella ) bacteria and Brucella species (spp) [ , ]. Some microorganisms, such as mycobacteria and dimorphic fungi, require longer incubation periods; others may require special culture media or non-culture-based methods. Although filamentous fungi often require special broth media or lysis-centrifugation vials for detection, most Candida spp grow very well in standard blood culture (...) per culture in adults injected into at least 2 blood culture bottles g Inoculated culture vials should be transported ASAP at RT to the laboratory for early incubation. Inoculated vials for direct detection of Candida spp by T2 magnetic resonance assay may be used [ ]. Infants and children: ≥2 blood culture sets (see above) As much blood as can be conveniently obtained from children; volume depends on weight of child c Organisms will usually survive in inoculated culture vials even

2018 Infectious Diseases Society of America PubMed abstract

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