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Cutaneous Candidiasis

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101. Dyspepsia - unidentified cause

with the updated NICE guidance. The prescribing information section has been expanded to include antibiotics recommended for H. pylori eradication. The topic has also undergone significant restructuring. Previous changes Previous changes December 2016 — minor update. minor update. Subacute cutaneous lupus erythematosus has been added as a very infrequent adverse effect of proton pump inhibitors, in line with a Medicines and Healthcare products Regulatory Agency (MHRA) Drug Safety Update (2015). July 2015

2018 NICE Clinical Knowledge Summaries

102. Rosacea - acne

, central face papules or pustules, or both. Phymatous rosacea, where thickening of the skin is seen with irregular surface nodularities, and enlargement. This may occur on the nose (rhinophyma), chin, forehead, cheeks or ears. Ocular rosacea, including inflammation of different parts of the eye and eyelid, which is usually bilateral. Granulomatous rosacea (a rare variant type of acne rosacea), which is non-inflammatory and characterised by hard, brown, yellow, or red cutaneous papules, or nodules (...) % for vehicle gel at day 29 (P<0.001). [ ]. Diffuse central facial erythema is often present, even in people who are not experiencing acute flare-ups of acne rosacea. The α-adrenergic agonist brimonidine has demonstrated vasoconstrictive and vasostabilising properties, as it targets α-adrenoreceptors in the smooth muscle sheath around the cutaneous blood vessels. However, brimonidine has no effect on capillaries and telangiectasia, which do not contain a smooth muscle layer [ ]. Brimonidine gel

2018 NICE Clinical Knowledge Summaries

103. Tropical Travel Trouble 011 Tonsillitis and the Bull

mouth beyond 1.5cm, and has a swollen neck (some might say ‘Bull neck’). In addition, he now has “ gurgly ” breathing. He is taken to OT to be intubated by ENT and they report a grade 4 airway with “ large grey tonsils and moist scales ”. Q1. What is your differential? Answer and interpretation Viral pharyngitis EBV Group A Strep Oral Candidiasis Epiglottitis Diphtheria Ludwigs angina Q2. What is the cause of this man’s tonsillitis? Answer and interpretation Diphtheria . The word diphtheria comes (...) pseudomembrane aspiration. Exotoxin mediated myocarditis occurs in up to 60% and is the second most common cause of death. The overall mortality rate from diphtheria is 5-10% even when adequately treated. In laryngeal diphtheria patients may only present with a cough and hoarseness as the larynx maybe the only site affected. Laryngoscopy will reveal a laryngeal pseudomembrane. 2. Cutaneous diphtheria Cutaneous diphtheria presents as a covered in a ‘dirty’ grey membrane. It occasionally progresses

2018 Life in the Fast Lane Blog

104. Paronychia - acute

features include: Pain and swelling at the base of the fingernail. Localized pain and tenderness of the nail folds. Red, tender, and swollen lateral and/or proximal nail folds often with a visible collection of pus. Conditions that may resemble paronychia include cutaneous candidiasis, acute contact dermatitis, staphylococcal whitlow, finger-tip injuries, insect bites, fungal nail infections, herpetic whitlow, cancer (for example melanoma or squamous cell carcinoma), psoriasis, Reiter syndrome (...) for recommendation Typical symptoms of acute paronychia This information is based on expert opinion in review articles [ ; ; ; ]. Findings on examination This information is based on expert opinion in review articles [ ; ; ; ]. Digital pressure test The guidance on how to carry out a digital pressure test to assess for early infection is based on expert opinion in a review article [ ]. Differential diagnosis What else could it be? Conditions that may resemble paronychia include: Cutaneous candidiasis. Acute

2017 NICE Clinical Knowledge Summaries

105. Pruritus vulvae

to occur in approximately 0.5% of the Western European and American population — in vulval clinics, it affects around 10–35% of people. Lichen sclerosus is estimated to occur in 1 in 300–1000 women. It is estimated that up to 75% of women will be affected by vulvovaginal candidiasis at least once in their lifetime and that 10% of women will see a doctor for persistent vulval itch at some time in their lives. [ ; ; ; ; ] Prognosis What is the prognosis? The prognosis of pruritus vulvae depends (...) . Extragenital itch may indicate a more generalized problem. For more information, see the CKS topic on . Lichen sclerosus is normally confined to the vulva, typically does not affect the vagina and very rarely involves the oral mucosa, while lichen planus may affect the vagina, skin, hair, nails, as well as genital and oral mucous membranes. Acute onset is associated with allergic contact dermatitis, or vulvovaginal candidiasis (which is the most common cause of acute vulval itch). For more information, see

2017 NICE Clinical Knowledge Summaries

106. Candida - skin

are the core search terms that were used for Medline. candidiasis, cutaneous/, skin diseases, infectious/, intertrigo/, exp candida/, exp dermatomycoses/, skin.tw, candid$.tw, intertrigo.tw, thrush.tw, moniliasis.tw. Sources of guidelines Medline (with guideline filter) (occupational health practice) Sources of systematic reviews and meta-analyses : Systematic reviews Protocols Database of Abstracts of Reviews of Effects Medline (with systematic review filter) EMBASE (with systematic review filter) Sources (...) mucocutaneous candidiasis. New Zealand Dermatological Society. . [ ] Erbagci,Z. ( 2004 ) Topical therapy for dermatophytoses: should corticosteroids be included?. 5 ( 6 ), 375 - 384 . [ ] Evans,E.C. and Gray,M. ( 2003 ) What interventions are effective for the prevention and treatment of cutaneous candidiasis?. 30 ( 1 ), 11 - 16 . Griffiths,C.E.M. and Barker,J.N.W,N. ( 2010 ) Rook's textbook of dermatology. In: Burns,T., Breathnach,S., Cox,N., Griffiths,C. (Eds.) Psoriasis. Sussex: Wiley-Blackwell., 20.1

2017 NICE Clinical Knowledge Summaries

107. Candida - oral

Candida - oral Candida - oral - NICE CKS Share Candida - oral: Summary Candida is a yeast-like fungus which is part of the normal commensal flora of the human gastrointestinal tract. Colonization with Candida is usually asymptomatic. However, if mucosal barriers are disrupted or defences lowered, it can cause infections ranging from non-life threatening superficial mucocutaneous disorders to invasive disseminated disease involving multiple organs. Oral candidiasis is most commonly caused (...) by Candida albicans . There are different types of oral candidiasis, including pseudomembranous candidiasis (often called oral thrush [which commonly affects neonates]), denture stomatitis (which commonly affects denture wearers), and chronic plaque-like candidiasis (which commonly occurs in men older than 30 years of age, and smokers). Comorbidities that increase the risk of candidal infections include diabetes mellitus, severe anaemia, and immunocompromise (such as due to chemotherapy, radiotherapy

2017 NICE Clinical Knowledge Summaries

108. Candida - female genital

Candida - female genital Candida - female genital - NICE CKS Share Candida - female genital: Summary Vulvovaginal candidiasis (genital thrush) is a symptomatic inflammation of the vagina and/or vulva caused by a superficial fungal infection. Most cases are caused by a Candida yeast, although other yeasts are occasionally implicated. Vulvovaginal candidiasis infection can be classified as: Uncomplicated, which is sporadic or infrequent, mild to moderate, likely to be due to Candida albicans (...) (usually white, 'cheese-like', and non-offensive), superficial dyspareunia, and dysuria. Signs may include vulvovaginal inflammation and erythema, vaginal fissuring, and excoriation of the vulva. Microscopy and fungal culture of vaginal secretions to identify yeasts is only recommended for supporting the diagnosis and in cases of severe or recurrent vulvovaginal candidiasis, or treatment failure. Treatment of uncomplicated infection involves: A short course of an intravaginal antifungal

2017 NICE Clinical Knowledge Summaries

109. Efficacy of topical antifungal drugs in different dermatomycoses: a systematic review with meta-analysis.

Efficacy of topical antifungal drugs in different dermatomycoses: a systematic review with meta-analysis. To evaluate and compare the efficacy of topical antifungal drugs applied to the treatment of each dermatomycosis.A systematic review of randomized clinical trials, published in Portuguese, Spanish and English until July 2010, which compared the use of azole and allylamine antifungal drugs among themselves and with placebo in the treatment of cutaneous candidiasis and T. versicolor, T. pedis

2016 Revista da Associacao Medica Brasileira (1992)

111. Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections

and Treatment for Purulent SSTIs (Cutaneous Abscesses, Furuncles, Carbuncles, and Inflamed Epidermoid Cysts)? Recommendations Gram stain and culture of pus from carbuncles and abscesses are recommended, but treatment without these studies is reasonable in typical cases (strong, moderate). Gram stain and culture of pus from inflamed epidermoid cysts are not recommended (strong, moderate). Incision and drainage is the recommended treatment for inflamed epidermoid cysts, carbuncles, abscesses, and large (...) decontamination of personal items such as towels, sheets, and clothes for recurrent S. aureus infection (weak, low). Adult patients should be evaluated for neutrophil disorders if recurrent abscesses began in early childhood (strong, moderate). IV. What Is Appropriate for the Evaluation and Treatment of Erysipelas and Cellulitis? Recommendations Cultures of blood or cutaneous aspirates, biopsies, or swabs are not routinely recommended (strong, moderate). Cultures of blood are recommended (strong, moderate

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2014 Infectious Diseases Society of America

112. Management of vulval conditions

be reinforced by giving them clear and accurate written information. (The British Society for the Study of Vulval Disease produces some patient information leaflets 3 www.bssvd.org/leaflets.asp, also include BAD leaflets, ISSVD, Vulval Pain Society and NZ Dermnet ) ? The patient’s GP should be informed. ? STI screening should be considered in all patients and vulvovaginal candidiasis excluded if the patient presents with vulval itch. ? All patients should be assessed for sexual dysfunction Sexual partners (...) . Classical: typical papules will be found on the keratinised anogenital skin, with or without striae on the inner aspect of the vulva. Hyperpigmentation frequently follows their resolution, particularly those with dark-skin. This type of lichen planus may be asymptomatic. Vulval lesions were found in 19 out of 37 women with cutaneous lichen planus, with four of the 19 having had no symptoms 17 2. Hypertrophic: these lesions are relatively rare and can be difficult to diagnose. They particularly affect

2014 British Association for Sexual Health and HIV

113. HIV, viral hepatitis and STIs - a guide for primary care

virus infection Human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) exchange of body fluids during sex all sexually active people Kaposi’s sarcoma (KS) Human herpes virus 8 (HHV-8) uncertain, probably exchange of body fluids predominantly MSM molluscum contagiosum Molluscum contagiosum (pox) virus (MCV) direct skin-to-skin contact all sexually active people YEASTS candidiasis Candida spp (ubiquitous commensals, only incidentally sexually transmitted) genital mm-to-mm contact all sexually

2014 Clinical Practice Guidelines Portal

114. Evaluation Genotypic, Phenotypic and Prognosis APECED Syndrome

control, known as APECED syndrome (Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy) or autoimmune polyendocrinopathy type 1, Criteria Inclusion Criteria: patients with at least 2 major criteria out of the following 3: hypoparathyroidism of autoimmune origin, adrenal insufficiency of autoimmune origin, chronic cutaneous and mucosal candidiasis. patients with only 1 of the 3 major criteria, associated with at least 2 of the following minor criteria: hypergonadotropic hypogonadism (...) Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED) Syndrome Study Start Date : July 2009 Estimated Primary Completion Date : February 2020 Estimated Study Completion Date : February 2020 Resource links provided by the National Library of Medicine related topics: resources: Groups and Cohorts Go to Outcome Measures Go to Primary Outcome Measures : allelic frequency of the mutation c.967-979del13 of the AIRE gene [ Time Frame: Baseline: one session ] Secondary Outcome Measures : total

2018 Clinical Trials

115. Burden of Serious Fungal Infections in Jordan (PubMed)

% of the population based on other countries, with 33% occurring in the ICU. Candida peritonitis/intra-abdominal candidiasis was estimated to affect 50% of the number of ICU candidemia cases. No adult asthma rates have been recorded for Jordan, so the rate from the Holy Land (8.54% clinical asthma) from To et al. has been used. There are an estimated 49,607 chronic obstructive pulmonary disease (COPD) patients in Jordan, with 64% symptomatic, 25% Gold stage 3% or 4%, and 7% (3472) are assumed to be admitted (...) to hospital each year. No cystic fibrosis cases have been recorded. Literature searches on fungal infections revealed few data and no prevalence data on fungal keratitis or tinea capitis, even though tinea capitis comprised 34% of patients with dermatophytoses in Jordan.Jordan has 6.3 million inhabitants (65% adults, 6% are >60 years old). The current burden of serious fungal infections in Jordan was estimated to affect ~119,000 patients (1.9%), not including any cutaneous fungal infections. Candidemia

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2018 Journal of Fungi

116. MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus

Description: Lichen sclerosus (LS) is a chronic cutaneous disorder affecting approximately one in seventy women. Presenting symptoms may include intense pruritus, pain, burning, and severe dyspareunia. This disorder may affect any area of the skin, but has a notable predilection for the anogenital skin. Extra-genital involvement is infrequent, affecting only 11% of women with LS. Affected females outnumber affect males by 10:1. There is bimodal peak incidence in premenarchal girls and menopausal women (...) , molluscum, condyloma). Have been diagnosed with other vulvar dermatologic conditions including lichen planus, psoriasis, lichen simplex chronicus, candidiasis, intraepithelial neoplasia, or carcinoma. Are pregnant or breastfeeding. If you become pregnant while on the study, you must withdraw from the study. Have received an investigational drug within four weeks prior to the study or who plan to use other investigational drugs during the course of this study. Have severe medical condition(s

2018 Clinical Trials

117. Investigation of Intertriginous Mycotic and Pseudomycotic (Erythrasma) Infections and Their Causative Agents with Emphasize on Clinical Presentations (PubMed)

was carried out in 2015-2016, on 188 patients with clinical suspicion of superficial and cutaneous intertriginous infections in Tehran, Iran. Demographic and additional related data were obtained by questionnaire from all participants. Specimens were collected by gentle scraping of the affected areas. Direct examination and culture were performed for all specimens and grown colonies were identified based on the macroscopic and microscopic features. Supplementary tests were done whenever needed. Data were (...) analyzed in SPSS.Overall, 80 (42.5%) cases with the mean age of 43.5 yr were confirmed for intertrigo. Dermatophytosis was the predominant cause in this study with 36 (45%) cases followed by erythrasma (28 cases, 35%), tinea versicolor (10 cases, 12.5%) and candidiasis (6 cases, 7.5%). Intertrigo lesions with dermatophytic agents significantly were observed in groin in comparison to different infections among body sites (P<0.05). Itching was the most common clinical presentation (57 cases, 71.3

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2018 Iranian journal of public health

118. Oral Complications of Chemotherapy and Head/Neck Radiation (PDQ®): Health Professional Version

Therapies: Oral Care Study Group Systematic Reviews, MASCC/ISOO Complication Reference Citation Weighted Prevalence Bisphosphonate osteonecrosis [ ] 6.1% for all studies (mean) Studies with documented follow-up = 13.3% Studies with undocumented follow-up = 0.7% Epidemiological studies = 1.2% Dysgeusia [ ] CT only = 56.3% (mean) RT only = 66.5% (mean) Combined CT and RT = 76% (mean) Oral fungal infection [ ] Of clinical oral fungal infection (all oral candidiasis): Pretreatment = 7.5% During treatment (...) = 39.1% Posttreatment = 32.6% Of oral candidiasis clinical infection by cancer treatment: During HNC RT = 37.4% During CT = 38% Oral viral infection [ ] In patients treated with CT for hematologic malignancies: Patients with oral ulcerations/sampling oral ulcerations = 49.8% Patients sampling oral ulcerations = 33.8% Patients sampling independently of the presence of oral ulcerations = 0% In patients treated with RT: Patients with RT only/sampling oral ulcerations = 0% Patients with RT and adjunctive

2016 PDQ - NCI's Comprehensive Cancer Database

119. Herpes simplex - oral

candidiasis. For more information, see the CKS topic on . Glandular fever (infectious mononucleosis). For more information, see the CKS topic on . Erythema multiforme — a hypersensitivity reaction often triggered by herpes simplex virus, that typically produces target-shaped lesions, which may affect the face. Hand, foot, and mouth disease. For more information, see the CKS topic on . Shingles — painful crops of blisters in a dermatomal distribution. For more information, see the CKS topic (...) on . Pharyngitis (for example, streptococcal). For more information, see the CKS topic on . Pemphigus vulgaris — rare bullous disease that can cause oral ulcers, cutaneous bullae, and erosions. Bullous pemphigoid — an autoimmune bullous disease that typically affects the elderly. Traumatic lesions (mechanical, thermal, or chemical). Mucositis from chemotherapy or radiation treatment. Basis for recommendation Basis for recommendation The information on the differential diagnoses of herpes simplex labialis

2016 NICE Clinical Knowledge Summaries

120. A URA3 null mutant of Candida albicans (CAI-4) causes oro-oesophageal and gastric candidiasis and is lethal for gnotobiotic, transgenic mice (Tg{epsilon}26) that are deficient in both natural killer and T cells. (PubMed)

A URA3 null mutant of Candida albicans (CAI-4) causes oro-oesophageal and gastric candidiasis and is lethal for gnotobiotic, transgenic mice (Tg{epsilon}26) that are deficient in both natural killer and T cells. Current data suggest that functional URA3 genes are necessary for the full pathogenesis of Candida albicans. Herein it is shown that a putatively avirulent URA3/URA3 null mutant of C. albicans (CAI-4) can colonize the murine alimentary tract, invade oro-oesophageal and gastric tissues (...) with yeasts and hyphae, evoke a granulocyte-dominated inflammatory response, and kill transgenic mice that are deficient for both natural killer cells and T cells. Because C. albicans-colonized (gnotobiotic) mice lack a viable prokaryotic microbiota, this study also demonstrates that the gut microbiome is not required to supply the mutant's nutritional needs. The gnotobiotic murine model described herein can be used to assess the capacity of C. albicans mutants to colonize and infect cutaneous, mucosal

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2009 Journal of Medical Microbiology

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