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Cutaneous Candidiasis

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101. Successful use of posaconazole to treat invasive cutaneous fungal infection in a liver transplant patient on sirolimus (Full text)

Successful use of posaconazole to treat invasive cutaneous fungal infection in a liver transplant patient on sirolimus Fungi are an important and common cause of cutaneous infections affecting solid organ transplant recipients. These infections can represent a primary site of infection with the potential for dissemination, or a manifestation of metastatic infection. The high morbidity and mortality associated with these infections necessitates urgent therapy with antifungal drugs; however (...) , the interaction between these drugs and immunosuppressive therapies can be a major limitation because of drug toxicity. A case of soft tissue infection of the toe caused by Fusarium chlamydosporum and Candida guilliermondii in a liver transplant patient on sirolimus, who was successfully treated with the new antifungal agent posaconazole, is described. The pharmacokinetic interactions of sirolimus and the new triazoles, and their impact on treatment choices are briefly discussed.

2012 The Canadian Journal of Infectious Diseases & Medical Microbiology PubMed abstract

102. Comparative serological and cutaneous reactivity of candidal cytoplasmic proteins and mannan separated by affinity for concanavalin A. (Full text)

Comparative serological and cutaneous reactivity of candidal cytoplasmic proteins and mannan separated by affinity for concanavalin A. Yeast-form Candida albicans cells were disrupted for 1.5 min in a Braun homogenizer and centrifuged at 100,000 X g. The supernatant was concentrated by ammonium sulfate precipitation and then dialyzed. The resulting material (650 mg), containing 81.2% protein and 11.5% carbohydrate, was subjected to affinity chromatography on concanavalin A (Con A) linked (...) of mannan reacted in immunoelectrophoresis with sera from infected rabbits and patients with chronic candidiasis. These same sera also reacted with a mannan-protein complex eluted from the Con A column with alpha-methyl mannoside. The comparative ability of candidal proteins and cell wall-derived mannan to elicit skin test reactions in guinea pigs sensitized by infection or with formaldehyde-killed yeast was studied. Candidal proteins at a 10-mug dose elicited positive reactions at 6 and 21 days after

1977 Journal of clinical microbiology PubMed abstract

103. Chronic Mucocutaneous Candidiasis

and .) Chronic mucocutaneous candidiasis is a that involves . Inheritance may be Autosomal dominant: Involving a mutation in the signal transducer and activator of transcription 1 gene ( STAT1 ) Autosomal recessive: Involving a mutation in the autoimmune regulator gene ( AIRE ) In the recessive form (autoimmune polyendocrinopathy–candidosis-ectodermal dystrophy), autoimmune manifestations typically develop; they include endocrine disorders (eg, , , , , ), , , and . Mutations may also occur in genes (...) fungal invasion) Patients have cutaneous anergy to Candida , absent proliferative responses to Candida antigen (but normal proliferative responses to mitogens), and intact antibody response to Candida and other antigens. recurs or persists, usually beginning during infancy but sometimes during early adulthood. Life span is not affected. Some patients also have deficient humoral immunity (sometimes called antibody deficiency), characterized by abnormal antibody responses to polysaccharide antigens

2013 Merck Manual (19th Edition)

104. Candidiasis (Mucocutaneous)

Medical Center Click here for Patient Education NOTE: This is the Professional Version. CONSUMERS: Topic Resources Candidiasis is skin and mucous membrane infection with Candida sp, most commonly Candida albicans . Infections can occur anywhere and are most common in skinfolds, digital web spaces, genitals, cuticles, and oral mucosa. Symptoms and signs vary by site. Diagnosis is by clinical appearance and potassium hydroxide wet mount of skin scrapings. Treatment is with drying agents and antifungals (...) . Most candidal infections are of the skin and mucous membranes, but invasive candidiasis is common among immunosuppressed patients and can be life threatening. Systemic candidiasis is discussed in . Vulvovaginal candidiasis is discussed in . Etiology Potentially pathogenic fungi include dermatophytes and yeast. Candida is a group of about 150 yeast species. C. albicans is responsible for about 70 to 80% of all candidal infections. Other significant species include C. glabrata, C. tropicalis, C

2013 Merck Manual (19th Edition)

105. Cutaneous findings in sporadic and familial autosomal dominant hyper-IgE syndrome: A retrospective, single-center study of 21 patients diagnosed using molecular analysis. (Abstract)

, and buttocks. All patients presented with infected dermatitis (Staphylococcus aureus) and 59% had chronic candidiasis of the oral mucosa and nails. Cutaneous herpes virus infections were not unusually severe. Coarse facial skin at puberty, and sometimes at a younger age, with prominent follicular ostia resembling atrophoderma vermiculatum was not related to severe acne or facial abscesses.This was a retrospective study with a small number of patients.When associated with serum IgE levels 10 times the age (...) Cutaneous findings in sporadic and familial autosomal dominant hyper-IgE syndrome: A retrospective, single-center study of 21 patients diagnosed using molecular analysis. Recent identification of STAT3 mutations in autosomal dominant (AD) hyper-IgE syndrome (HIES) has improved the clinical, genetic, and molecular classification of the HIES.We sought to characterize the cutaneous signs observed in molecularly diagnosed AD-HIES.We conducted a retrospective study of 21 patients with AD-HIES

2011 Journal of American Academy of Dermatology

106. List of cutaneous conditions

tuberculous complex, tuberculous chancre) (tuberculosis cutis colliquativa) (acute tuberculous ulcer, orificial tuberculosis) (lupus verrucosus, prosector's wart, warty tuberculosis) (metastatic tuberculous abscess, metastatic tuberculous ulcer) Mycosis-related [ ] See also: and Mycosis-related cutaneous conditions are caused by or , and may present as either a superficial or deep of the skin, hair, or nails. (iatrogenic candidiasis) (chromomycosis, cladosporiosis, Fonseca's disease, Pedroso's disease (...) List of cutaneous conditions List of cutaneous conditions - Wikipedia List of cutaneous conditions From Wikipedia, the free encyclopedia See also: , , and This is a and may never be able to satisfy particular standards for completeness. You can help by with entries. Many conditions affect the human —the covering the entire surface of the and composed of , , , and related and . The major function of this system is as a barrier against the external environment. The skin weighs an average of four

2012 Wikipedia

107. Upadacitinib (Rinvoq) - rheumatoid arthritis

risks of serious infections and potential HBV reactivation. 8.5.2. Adverse Events of Special Interest: Opportunistic Infections: Excluding Tuberculosis Controlled Period Analysis of the “PBO-controlled UPA 15 mg” analysis set showed a similar proportion of opportunistic infections in PBO- and UPA 15 mg-treated subjects (Table 100). All opportunistic infections in the UPA 15 mg group were nonserious mucosal candidiasis including four cases of oral candidiasis and one case of esophageal candidiasis (...) . Three cases of opportunistic infections occurred in the PBO arm: one case of oral candidiasis and two serious cases of pneumocystis jirovecii pneumonia (one death and one discontinuation of study drug). Reference ID: 4476845Clinical Review Keith M Hull, MD, PhD NDA 211675 RINVOQ (upadacitinib) Table 100. TEAEs of Opportunistic Infections in Subjects During the Controlled Period Comparing PBO vs. UPA 15mg Prior to Treatment Switching (PBO-Controlled UPA 15 mg Analysis Set) MedDRA Preferred Term PBO

2019 FDA - Drug Approval Package

108. Refractory extrapulmonary sarcoidosis: infliximab

of 41According to specialists involved in this evidence summary, infliximab may be an option for some patients with severe, refractory extrapulmonary sarcoidosis (particularly cutaneous or neurological sarcoidosis); for example, those affected by disabling or disfiguring disease, or whose life expectancy is likely to be reduced. Regulatory status: Regulatory status: Use of infliximab for treating any manifestation of sarcoidosis is off-label. At the time of publication, 4 infliximab products are available (...) , Chapelon-Abric et al. 2015, Doty et al. 2005, Hostettler et al. 2011, Ørum et al. 2012, Panselinas et al. 2009, Russell et al. 2013, Sweiss et al. 2005 and Van Rijswijk et al. 2013): the disease resolved in 51 (33%), improved in 71 (46%), resolved or improved in 10 (with individual data for each outcome not reported, 6%), remained stable in 22 (14%) and deteriorated in 1 (1%). neurological sarcoidosis (n=52) resolved in 21 (40%) improved in 24 (46%) and remained stable in 7 (13%). cutaneous sarcoidosis

2017 National Institute for Health and Clinical Excellence - Advice

109. Nappy rash

by a nappy. It is primarily an irritant contact dermatitis. The main irritants are urine, faeces, and faecal enzymes, which lead to skin breakdown, typically of the perineum and convex surfaces of the buttocks, with sparing of the skin folds. History and exam presence of risk factors acute onset of rash in nappy area erythema of convex surfaces in nappy area sparing of skin folds features of candidiasis features of Staphylococcus aureus infection features of group A Streptococcus infection fussiness (...) Virginia University School of Medicine Morgantown WV Disclosures LSN is an author of references cited in this topic. Professor of Pediatrics Vice Chair for Education Department of Pediatrics Wayne State University School of Medicine Designated Institutional Official Children's Hospital of Michigan Detroit MI Disclosures DK is an author of references cited in this topic. Peer reviewers Assistant Professor of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL

2018 BMJ Best Practice

110. Overview of HIV

of the genus Candida , mostly C albicans . Although Candida are considered normal flora in the gastrointestinal and genitourinary tracts in humans, they are capable of local infection of mucous membranes (oropharyngeal candidiasis, oesophagitis, vulvovaginitis), focal invasion (endophthalmitis, meningitis, endocarditis), and dissemination (candidaemia). The most common neoplasm arising in HIV-positive people. It is a low-grade vasoformative neoplasm associated with human herpesvirus-8 (HHV-8) or Kaposi (...) to HIV, there may be a brief period before the infection is established, during which antiretroviral therapy may successfully prevent viral replication. Clinical syndromes that arise as a consequence of impaired immunity in advanced stages of HIV infection. These illnesses tend to occur most often in patients who have untreated HIV infection or who fail to benefit from antiretroviral therapy. Tuberculosis, Pneumocystis jirovecii pneumonia, candidiasis, cryptococcosis, toxoplasmosis, cytomegalovirus

2018 BMJ Best Practice

111. Assessment of rash in children

, disseminated intravascular coagulation). Differentials Roseola infantum (sixth disease) Erythema infectiosum (fifth disease) Epstein-Barr virus (EBV) infection Atopic dermatitis Seborrhoeic dermatitis Irritant contact dermatitis Pityriasis rosea Impetigo Tinea corporis Scabies Insect bites or stings Child abuse Cutaneous candidiasis Cutaneous herpes simplex Molluscum contagiosum Varicella-zoster Rubeola (measles) Cytomegalovirus (CMV) infection Hepatitis B Hepatitis C HIV seroconversion Rubella (German (...) Assessment of rash in children Assessment of rash in children - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of rash in children Last reviewed: February 2019 Last updated: December 2018 Summary Childhood rashes are cutaneous eruptions of acute onset. Clinically, they may be categorised as maculopapular, pustular, vesiculobullous, diffuse/erythematous, or petechial/purpuric in nature. However, in many

2018 BMJ Best Practice

112. Assessment of dermatological disorders in HIV

; past, present and future! Int J Dermatol. 2004;43:468-470. http://www.ncbi.nlm.nih.gov/pubmed/15186235?tool=bestpractice.com Cutaneous manifestations often reflect immune status and may offer insight into long-term prognosis. Although morbidity from skin diseases, particularly from opportunistic infection, has decreased with the advent of antiretroviral treatment, there are still significant dermatological problems in the post-antiretroviral therapy era. Dermatological disorders in HIV may (...) be categorised as infectious, inflammatory, neoplastic, drug reaction, and metabolic. Differentials Psoriasis Seborrhoeic dermatitis Atopic dermatitis Xerosis Perioral dermatitis Acne vulgaris Human papillomavirus (HPV) - warts or condylomata acuminata Herpes simplex virus (HSV) Varicella zoster virus (VZV) Folliculitis Syphilis (Treponema pallidum) Scabies Insect bite Candida Basal cell carcinoma (BCC) HIV-related lipodystrophy Nail lesions Gonorrhoea Chlamydia/LGV Aphthous ulcers Photodermatitis Prurigo

2018 BMJ Best Practice

113. Overview of dermatitis

dermatitis, superficial fungal (tinea and candidiasis) and dermatophyte infections, lichen sclerosis, viral warts, scabies, lice, arthropod bite, or cutaneous neoplasia. Lotti T, Buggaiani G, Prignano F. Prurigo nodularis and lichen simplex chronicus. Dermatol Ther. 2008 Jan-Feb;21(1):42-6. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1529-8019.2008.00168.x http://www.ncbi.nlm.nih.gov/pubmed/18318884?tool=bestpractice.com Lynch PJ. Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital (...) , and management of diaper dermatitis. Clin Pediatr (Phila). 2007 Jul;46(6):480-6. http://www.ncbi.nlm.nih.gov/pubmed/17579099?tool=bestpractice.com Circumscribed lichenified erythematous, often hyperpigmented, cutaneous plaques occurring most commonly on the scalp, neck, forearms, ankles, and genitalia as a result of chronic scratching and rubbing. One or multiple LSC patches or plaques can arise on skin affected by an underlying dermatosis such as atopic dermatitis, allergic contact dermatitis, stasis

2018 BMJ Best Practice

114. Overview of dermatitis

dermatitis, superficial fungal (tinea and candidiasis) and dermatophyte infections, lichen sclerosis, viral warts, scabies, lice, arthropod bite, or cutaneous neoplasia. Lotti T, Buggaiani G, Prignano F. Prurigo nodularis and lichen simplex chronicus. Dermatol Ther. 2008 Jan-Feb;21(1):42-6. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1529-8019.2008.00168.x http://www.ncbi.nlm.nih.gov/pubmed/18318884?tool=bestpractice.com Lynch PJ. Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital (...) , and management of diaper dermatitis. Clin Pediatr (Phila). 2007 Jul;46(6):480-6. http://www.ncbi.nlm.nih.gov/pubmed/17579099?tool=bestpractice.com Circumscribed lichenified erythematous, often hyperpigmented, cutaneous plaques occurring most commonly on the scalp, neck, forearms, ankles, and genitalia as a result of chronic scratching and rubbing. One or multiple LSC patches or plaques can arise on skin affected by an underlying dermatosis such as atopic dermatitis, allergic contact dermatitis, stasis

2018 BMJ Best Practice

115. Assessment of rash in children

, disseminated intravascular coagulation). Differentials Roseola infantum (sixth disease) Erythema infectiosum (fifth disease) Epstein-Barr virus (EBV) infection Atopic dermatitis Seborrhoeic dermatitis Irritant contact dermatitis Pityriasis rosea Impetigo Tinea corporis Scabies Insect bites or stings Child abuse Cutaneous candidiasis Cutaneous herpes simplex Molluscum contagiosum Varicella-zoster Rubeola (measles) Cytomegalovirus (CMV) infection Hepatitis B Hepatitis C HIV seroconversion Rubella (German (...) Assessment of rash in children Assessment of rash in children - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of rash in children Last reviewed: February 2019 Last updated: December 2018 Summary Childhood rashes are cutaneous eruptions of acute onset. Clinically, they may be categorised as maculopapular, pustular, vesiculobullous, diffuse/erythematous, or petechial/purpuric in nature. However, in many

2018 BMJ Best Practice

116. Canadian Urological Association guideline for the diagnosis, management, and surveillance of neurogenic lower urinary tract dysfunction

disease exac-CUAJ • June 2019 • Volume 13, Issue 6 E164 Kavanagh et al erbations (e.g., MS) and are associated with decreased health-related QoL. 76 The Enterobacteriaceae family represents the most com- monly isolated organism in the NLUTD population, with E.coli comprising 50% of all strains. This is lower than that reported in non-neurogenic UTI and is in part explained by the increased incidence of Pseudomonas, Acinetobacter, Enterococcus, and fungi such as Candida. 77,78 Antimicrobial resistance

2019 Canadian Urological Association

117. Infection

structure infections : the ESTABLISH-1 randomized trial. 559-69 10.1001/jama.2013.241 Acute bacterial skin and skin structure infections (ABSSSIs), including cellulitis or erysipelas, major cutaneous (...) abscesses, and wound infections , can be life-threatening and may require surgery and hospitalization. Increasingly, ABSSSIs are associated with drug-resistant pathogens, and many antimicrobial agents have adverse effects restricting their use. Tedizolid phosphate is a novel oxazolidinone (...) (onychomycosis) can involve the nail plate, nail bed, and/or the root of the nail. It affects toenails more frequently than the fingernails. The infection evolves slowly causing discolouration of the nail unit, distortion of the nail plate, and thickening of the nail bed and adjacent tissue. The organisms responsible for fungal nail infection (...) are dermatophyte and non-dermatophyte moulds, and yeasts such as Candida . Dermatophyte moulds are responsible for the majority of cases. Fungal nail infection

2018 Trip Latest and Greatest

119. BTS Guideline for Bronchiectasis in adults

class analysis (the statistical test used to assess diag- nostic test performance in conditions without a diagnostic gold standard) showed that detection of Aspergillus-specifi- cIgE in blood was more sensitive than intradermal skin tests for the diagnosis of ABPA. 78 Diagnostic criteria for ABPA include positive IgE blood and cutaneous skin test results as there may be a small proportion of patients who have discrepant blood and skin test results. 73 Use of blood rather than cutaneous skin test has (...) to azole therapy and differences in sputum processing and culturing technologies in microbiology labora- tory services. 85 In the absence of stronger evidence, all the following criteria based on expert consensus are suggested for steroid naïve patients. º Associated clinical deterioration (increased cough, wheeze, increased sputum production, worsening lung function, exacerbations) º Total serum IgE level >500 IU/mL (or ku/L)- precise cut-off is not known. º Immediate cutaneous reaction to Aspergillus

2019 British Thoracic Society

120. Pruritus

. Pruritus and related conditions were present in 1.04% of consultations (male, 0.73%; female, 1.33%). In Crete, where patients with cutaneous disorders mostly present to hospitals rather than to primary care centres, PUO was diagnosed in 6.3% of 3,715 patients in 2003 (Symvoulakis, Krasagakis et al. 2006). In Germany and the Netherlands the prevalence of pruritus as a reason for consultation in primary care resulted in approximately 9 0.7% of all consultations, most of these resulting in a diagnosis (...) to be most pronounced in patients showing the JAK2 617V mutation (Siegel, Tauschert et al. 2013, Tefferi, Vannucchi et al. 2018). Pruritus in Hodgkin’s disease often starts on the legs and is most severe at night, but generalised pruritus soon ensues. Several factors such as secretion of leukopeptidases and bradykinin, histamine release and high IgE levels with cutaneous depositions may contribute to pruritus in lymphoma (Krajnik and Zylicz 2001). Patients with carcinoid syndrome may experience pruritus

2019 European Dermatology Forum

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