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Cutaneous Candidiasis

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61. Cutaneous manifestations of primary immunodeficiency. (PubMed)

Cutaneous manifestations of primary immunodeficiency. To show that skin symptoms help in the recognition of primary immunodeficiencies (PIDs). To analyze whether recent molecular data help in understanding genotype/phenotype relations.Erythroderma in Omenn syndrome may be caused by either mutations in genes associated with severe combined immunodeficiency (SCID) in which the generation of some T cells is possible, which results in potentially autoreactive lymphoid clones, or by selective (...) chronic mucocutaneous candidiasis, whereas a defective innate immune system predisposes to systemic candidiasis [congenital neutropenia, neutrophil dysfunction, and caspase recruitment domain 9 (CARD9) deficiency].Noninfectious granulomas may be the presenting symptom in innate immunity defects [such as chronic granulomatous disease (CGD) or in predominantly humoral immunodeficiencies such as common variable immunodeficiency], as well as ataxia teleangiectasia or rare recombination-activating gene

2013 Current Opinion in Pediatrics

62. Cutaneous findings in sporadic and familial autosomal dominant hyper-IgE syndrome: A retrospective, single-center study of 21 patients diagnosed using molecular analysis. (PubMed)

, and buttocks. All patients presented with infected dermatitis (Staphylococcus aureus) and 59% had chronic candidiasis of the oral mucosa and nails. Cutaneous herpes virus infections were not unusually severe. Coarse facial skin at puberty, and sometimes at a younger age, with prominent follicular ostia resembling atrophoderma vermiculatum was not related to severe acne or facial abscesses.This was a retrospective study with a small number of patients.When associated with serum IgE levels 10 times the age (...) Cutaneous findings in sporadic and familial autosomal dominant hyper-IgE syndrome: A retrospective, single-center study of 21 patients diagnosed using molecular analysis. Recent identification of STAT3 mutations in autosomal dominant (AD) hyper-IgE syndrome (HIES) has improved the clinical, genetic, and molecular classification of the HIES.We sought to characterize the cutaneous signs observed in molecularly diagnosed AD-HIES.We conducted a retrospective study of 21 patients with AD-HIES

2011 Journal of American Academy of Dermatology

63. Chronic Mucocutaneous Candidiasis

Chronic Mucocutaneous Candidiasis Chronic Mucocutaneous Candidiasis - Immunology; Allergic Disorders - MSD Manual Professional Edition Brought to you by The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases / / / / IN THIS TOPIC OTHER TOPICS IN THIS CHAPTER Test (...) improvement project can increase the frequency of both teratogen education and urine pregnancy... Video Overview of Antibody-Mediated Immunity Antibody-mediated immunity involves the activation of B cells and secretion of antibodies when in contact with a pathogen. When exposed to the chemicals released by activated helper... SOCIAL MEDIA Add to Any Platform Loading Topic Resources Chronic mucocutaneous candidiasis is persistent or recurrent candidal infection due to inherited T-cell defects. (See also

2013 Merck Manual (19th Edition)

64. Candidiasis (Mucocutaneous)

improperly done manicures and in kitchen workers and others whose hands are continually exposed to water (see ). In obese people, candidal infections may occur beneath the pannus (abdominal fold). Oropharyngeal candidiasis is a common sign of local or systemic immunosuppression. Chronic mucocutaneous candidiasis typically affects the nails, skin, and oropharynx. Patients have cutaneous anergy to Candida, absent proliferative responses to Candida antigen (but normal proliferative responses to mitogens (...) Candidiasis (Mucocutaneous) Candidiasis (Mucocutaneous) - Dermatologic Disorders - MSD Manual Professional Edition Brought to you by The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases / / / / IN THIS TOPIC OTHER TOPICS IN THIS CHAPTER Test your knowledge

2013 Merck Manual (19th Edition)

65. Comparative serological and cutaneous reactivity of candidal cytoplasmic proteins and mannan separated by affinity for concanavalin A. (PubMed)

Comparative serological and cutaneous reactivity of candidal cytoplasmic proteins and mannan separated by affinity for concanavalin A. Yeast-form Candida albicans cells were disrupted for 1.5 min in a Braun homogenizer and centrifuged at 100,000 X g. The supernatant was concentrated by ammonium sulfate precipitation and then dialyzed. The resulting material (650 mg), containing 81.2% protein and 11.5% carbohydrate, was subjected to affinity chromatography on concanavalin A (Con A) linked (...) of mannan reacted in immunoelectrophoresis with sera from infected rabbits and patients with chronic candidiasis. These same sera also reacted with a mannan-protein complex eluted from the Con A column with alpha-methyl mannoside. The comparative ability of candidal proteins and cell wall-derived mannan to elicit skin test reactions in guinea pigs sensitized by infection or with formaldehyde-killed yeast was studied. Candidal proteins at a 10-mug dose elicited positive reactions at 6 and 21 days after

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1977 Journal of clinical microbiology

66. Immunodeficiencies in chronic muco-cutaneous candidosis (PubMed)

Immunodeficiencies in chronic muco-cutaneous candidosis 4336639 1972 06 30 2018 11 13 0019-2805 22 5 1972 May Immunology Immunology Immunodeficiencies in chronic muco-cutaneous candidosis. 775-87 Lehner T T Wilton J M JM Ivanyi L L eng Journal Article England Immunology 0374672 0019-2805 0 Antigens 0 Immunoglobulin A 0 Immunoglobulin G 0 Immunoglobulins 9007-49-2 DNA IM Animals Antibody Formation Antigens Candida albicans immunology Candidiasis, Cutaneous immunology Cell Migration Inhibition

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1972 Immunology

67. ISOLATED CONGENITAL NAIL CANDIDIASIS: REPORT OF 6 CASES. (PubMed)

ISOLATED CONGENITAL NAIL CANDIDIASIS: REPORT OF 6 CASES. Congenital candidal infection usually presents as skin rash but it can also affect skin appendages. Nail involvement in congenital candidiasis is rare and has been usually associated with cutaneous lesions. We report 6 cases of congenital candidiasis limited to nail plates that had favorable outcome.

2010 Pediatric Infectious Dsease Journal

68. List of cutaneous conditions

tuberculous complex, tuberculous chancre) (tuberculosis cutis colliquativa) (acute tuberculous ulcer, orificial tuberculosis) (lupus verrucosus, prosector's wart, warty tuberculosis) (metastatic tuberculous abscess, metastatic tuberculous ulcer) Mycosis-related [ ] See also: and Mycosis-related cutaneous conditions are caused by or , and may present as either a superficial or deep of the skin, hair, or nails. (iatrogenic candidiasis) (chromomycosis, cladosporiosis, Fonseca's disease, Pedroso's disease (...) List of cutaneous conditions List of cutaneous conditions - Wikipedia List of cutaneous conditions From Wikipedia, the free encyclopedia See also: , , and This is a and may never be able to satisfy particular standards for completeness. You can help by with entries. Many conditions affect the human —the covering the entire surface of the and composed of , , , and related and . The major function of this system is as a barrier against the external environment. The skin weighs an average of four

2012 Wikipedia

69. Upadacitinib (Rinvoq) - rheumatoid arthritis

risks of serious infections and potential HBV reactivation. 8.5.2. Adverse Events of Special Interest: Opportunistic Infections: Excluding Tuberculosis Controlled Period Analysis of the “PBO-controlled UPA 15 mg” analysis set showed a similar proportion of opportunistic infections in PBO- and UPA 15 mg-treated subjects (Table 100). All opportunistic infections in the UPA 15 mg group were nonserious mucosal candidiasis including four cases of oral candidiasis and one case of esophageal candidiasis (...) . Three cases of opportunistic infections occurred in the PBO arm: one case of oral candidiasis and two serious cases of pneumocystis jirovecii pneumonia (one death and one discontinuation of study drug). Reference ID: 4476845Clinical Review Keith M Hull, MD, PhD NDA 211675 RINVOQ (upadacitinib) Table 100. TEAEs of Opportunistic Infections in Subjects During the Controlled Period Comparing PBO vs. UPA 15mg Prior to Treatment Switching (PBO-Controlled UPA 15 mg Analysis Set) MedDRA Preferred Term PBO

2019 FDA - Drug Approval Package

70. Cutaneous expression of systemic candidiasis. (PubMed)

Cutaneous expression of systemic candidiasis. Skin lesions associated with Candida septicaemia occur only in a minority of patients, who are usually immunocompromised, but they can help to establish a diagnosis rapidly. The lesions form a characteristic maculopapular or nodular rash at the onset of the infection. We report three cases of systemic candidiasis (SC) with cutaneous manifestations in immunocompromised patients. In these patients, the lesions started as asymptomatic or slightly

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2009 Clinical & Experimental Dermatology

71. Nappy rash

by a nappy. It is primarily an irritant contact dermatitis. The main irritants are urine, faeces, and faecal enzymes, which lead to skin breakdown, typically of the perineum and convex surfaces of the buttocks, with sparing of the skin folds. History and exam presence of risk factors acute onset of rash in nappy area erythema of convex surfaces in nappy area sparing of skin folds features of candidiasis features of Staphylococcus aureus infection features of group A Streptococcus infection fussiness (...) Virginia University School of Medicine Morgantown WV Disclosures LSN is an author of references cited in this topic. Professor of Pediatrics Vice Chair for Education Department of Pediatrics Wayne State University School of Medicine Designated Institutional Official Children's Hospital of Michigan Detroit MI Disclosures DK is an author of references cited in this topic. Peer reviewers Assistant Professor of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL

2018 BMJ Best Practice

72. Overview of dermatitis

dermatitis, superficial fungal (tinea and candidiasis) and dermatophyte infections, lichen sclerosis, viral warts, scabies, lice, arthropod bite, or cutaneous neoplasia. Lotti T, Buggaiani G, Prignano F. Prurigo nodularis and lichen simplex chronicus. Dermatol Ther. 2008 Jan-Feb;21(1):42-6. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1529-8019.2008.00168.x http://www.ncbi.nlm.nih.gov/pubmed/18318884?tool=bestpractice.com Lynch PJ. Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital (...) , and management of diaper dermatitis. Clin Pediatr (Phila). 2007 Jul;46(6):480-6. http://www.ncbi.nlm.nih.gov/pubmed/17579099?tool=bestpractice.com Circumscribed lichenified erythematous, often hyperpigmented, cutaneous plaques occurring most commonly on the scalp, neck, forearms, ankles, and genitalia as a result of chronic scratching and rubbing. One or multiple LSC patches or plaques can arise on skin affected by an underlying dermatosis such as atopic dermatitis, allergic contact dermatitis, stasis

2018 BMJ Best Practice

73. Overview of HIV

to HIV, there may be a brief period before the infection is established, during which antiretroviral therapy may successfully prevent viral replication. Clinical syndromes that arise as a consequence of impaired immunity in advanced stages of HIV infection. These illnesses tend to occur most often in patients who have untreated HIV infection or who fail to benefit from antiretroviral therapy. Tuberculosis, Pneumocystis jirovecii pneumonia, candidiasis, cryptococcosis, toxoplasmosis, cytomegalovirus (...) by a functioning immune system. When re-activation (or primary infection) occurs in patients with severely compromised immune function (transplant patients, or AIDS patients with CD4 count <50 cells/microlitre), uncontrolled CMV replication often ensues, which leads to the clinical manifestations characterised by fever, bone marrow suppression, and tissue-invasive disease. Common opportunistic infection in people infected with HIV. Oral candidiasis involves a local infection of oral tissues by yeasts

2018 BMJ Best Practice

74. Assessment of rash in children

, disseminated intravascular coagulation). Differentials Roseola infantum (sixth disease) Erythema infectiosum (fifth disease) Epstein-Barr virus (EBV) infection Atopic dermatitis Seborrhoeic dermatitis Irritant contact dermatitis Pityriasis rosea Impetigo Tinea corporis Scabies Insect bites or stings Child abuse Cutaneous candidiasis Cutaneous herpes simplex Molluscum contagiosum Varicella-zoster Rubeola (measles) Cytomegalovirus (CMV) infection Hepatitis B Hepatitis C HIV seroconversion Rubella (German (...) Assessment of rash in children Assessment of rash in children - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of rash in children Last reviewed: February 2019 Last updated: December 2018 Summary Childhood rashes are cutaneous eruptions of acute onset. Clinically, they may be categorised as maculopapular, pustular, vesiculobullous, diffuse/erythematous, or petechial/purpuric in nature. However, in many

2018 BMJ Best Practice

75. Overview of dermatitis

dermatitis, superficial fungal (tinea and candidiasis) and dermatophyte infections, lichen sclerosis, viral warts, scabies, lice, arthropod bite, or cutaneous neoplasia. Lotti T, Buggaiani G, Prignano F. Prurigo nodularis and lichen simplex chronicus. Dermatol Ther. 2008 Jan-Feb;21(1):42-6. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1529-8019.2008.00168.x http://www.ncbi.nlm.nih.gov/pubmed/18318884?tool=bestpractice.com Lynch PJ. Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital (...) , and management of diaper dermatitis. Clin Pediatr (Phila). 2007 Jul;46(6):480-6. http://www.ncbi.nlm.nih.gov/pubmed/17579099?tool=bestpractice.com Circumscribed lichenified erythematous, often hyperpigmented, cutaneous plaques occurring most commonly on the scalp, neck, forearms, ankles, and genitalia as a result of chronic scratching and rubbing. One or multiple LSC patches or plaques can arise on skin affected by an underlying dermatosis such as atopic dermatitis, allergic contact dermatitis, stasis

2018 BMJ Best Practice

76. Assessment of rash in children

, disseminated intravascular coagulation). Differentials Roseola infantum (sixth disease) Erythema infectiosum (fifth disease) Epstein-Barr virus (EBV) infection Atopic dermatitis Seborrhoeic dermatitis Irritant contact dermatitis Pityriasis rosea Impetigo Tinea corporis Scabies Insect bites or stings Child abuse Cutaneous candidiasis Cutaneous herpes simplex Molluscum contagiosum Varicella-zoster Rubeola (measles) Cytomegalovirus (CMV) infection Hepatitis B Hepatitis C HIV seroconversion Rubella (German (...) Assessment of rash in children Assessment of rash in children - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of rash in children Last reviewed: February 2019 Last updated: December 2018 Summary Childhood rashes are cutaneous eruptions of acute onset. Clinically, they may be categorised as maculopapular, pustular, vesiculobullous, diffuse/erythematous, or petechial/purpuric in nature. However, in many

2018 BMJ Best Practice

79. Nappy rash

by a nappy. It is primarily an irritant contact dermatitis. The main irritants are urine, faeces, and faecal enzymes, which lead to skin breakdown, typically of the perineum and convex surfaces of the buttocks, with sparing of the skin folds. History and exam presence of risk factors acute onset of rash in nappy area erythema of convex surfaces in nappy area sparing of skin folds features of candidiasis features of Staphylococcus aureus infection features of group A Streptococcus infection fussiness (...) Virginia University School of Medicine Morgantown WV Disclosures LSN is an author of references cited in this topic. Professor of Pediatrics Vice Chair for Education Department of Pediatrics Wayne State University School of Medicine Designated Institutional Official Children's Hospital of Michigan Detroit MI Disclosures DK is an author of references cited in this topic. Peer reviewers Assistant Professor of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL

2017 BMJ Best Practice

80. Angular cheilitis

/15865910?tool=bestpractice.com The cause is usually multi-factorial, due either to a primary infection or to a non-infectious entity such as mechanical irritation, nutritional deficiency, or other dermatological condition. Rogers RS III, Bekic M. Diseases of the lips. Semin Cutan Med Surg. 1997 Dec;16(4):328-36. http://www.ncbi.nlm.nih.gov/pubmed/9421227?tool=bestpractice.com [Figure caption and citation for the preceding image starts]: Angular cheilitis From the collection of Dr Wanda C. Gonsalves (...) ; patient consent obtained [Citation ends]. [Figure caption and citation for the preceding image starts]: Angular cheilitis From the collection of Dr Wanda C. Gonsalves; patient consent obtained [Citation ends]. History and exam presence of risk factors dentures with palatal erythema oral candidiasis pruritus painful red fissures eczematous dermatitis of lower face specific medicines hx of inflammatory bowel disease hx of acid reflux hx of total parenteral nutrition hx of eating disorders alopecia

2017 BMJ Best Practice

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