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Cutaneous Candidiasis

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61. Novel lecithin-integrated liquid crystalline nanogels for enhanced cutaneous targeting of terconazole: development, in vitro and in vivo studies (Full text)

Novel lecithin-integrated liquid crystalline nanogels for enhanced cutaneous targeting of terconazole: development, in vitro and in vivo studies Terconazole (Tr) is the first marketed, most active triazole for vaginal candidiasis. Owing to poor skin permeation and challenging physicochemical properties, Tr was not employed for the treatment of cutaneous candidiasis. This is the first study to investigate the relevance of novel lecithin-integrated liquid crystalline nano-organogels (LCGs (...) ) to improve physicochemical characteristics of Tr in order to enable its dermal application in skin candidiasis. Ternary phase diagram was constructed using lecithin/capryol 90/water to identify the region of liquid crystalline organogel. The selected organogel possessed promising physicochemical characteristics based on particle size, rheological behavior, pH, loading efficiency, and in vitro antifungal activity. Microstructure of the selected organogel was confirmed by polarized light microscopy

2016 International journal of nanomedicine PubMed abstract

62. A retrospective study of cutaneous fungal infections in patients referred to Imam Reza Hospital of Mashhad, Iran during 2000-2011 (Full text)

suspected of superficial and cutaneous mycosis, referred to the Medical Mycology Laboratory of Imam Reza Hospital of Mashhad, Iran, were recruited during March 2000-2011 and were examined in terms of fungal infections.Of 8694 suspected patients, 3804 (43.75%) cases suffered from superficial and cutaneous mycosis. In total, 1936 (50.9%) patients were male, and 1868 (49.1%) were female. Malassezia infections (58.1%), dermatophytosis (33.1%), cutaneous candidiasis (6.8%), aspergillosis (1.6 (...) A retrospective study of cutaneous fungal infections in patients referred to Imam Reza Hospital of Mashhad, Iran during 2000-2011 Detection of agents responsible for cutaneous mycosis may be effective in the prevention of fungal infections from environmental and animal sources. With this background in mind, in this study, we aimed to identify the distribution of cutaneous mycotic infections in patients referred to Imam Reza Hospital of Mashhad, Iran during 2000- 2011.In total, 8694 patients

2016 Current Medical Mycology PubMed abstract

63. Hydroxychavicol: A phytochemical targeting cutaneous fungal infections (Full text)

potential and time-kill curve results revealed concentration-dependent killing. It also inhibited the growth of biofilm generated by Trichophyton mentagrophytes and Candida parapsilosis and reduced the preformed biofilms. Hydroxychavicol was highly effective in the treatment, and mycological eradication of an experimentally induced topical infection model of dermatophytosis (tinea corporis) and cutaneous candidiasis in guinea pigs, respectively. The mode of action of hydroxychavicol appears to originate (...) Hydroxychavicol: A phytochemical targeting cutaneous fungal infections The present study was designed to investigate the potency of hydroxychavicol on selected cutaneous human pathogenic fungi by the use of in vitro and in vivo assays and mechanistic characterization along with toxicological effects. Hydroxychavicol consistently displayed a fungicidal effect against all fungal species tested. Inoculum concentrations over the range of 104 to 107 CFU/ml did not significantly alter its antifungal

2016 Scientific reports PubMed abstract

64. A Phase 3 Study to Evaluate the Efficacy and Safety of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts

A Phase 3 Study to Evaluate the Efficacy and Safety of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts A Phase 3 Study to Evaluate the Efficacy and Safety of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Phase 3 Study to Evaluate the Efficacy and Safety of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov

2016 Clinical Trials

65. Candidiasis, Chronic Mucocutaneous (Overview)

> Chronic Mucocutaneous Candidiasis Updated: Apr 17, 2017 Author: Blanca Anais Estupiñan; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Chronic Mucocutaneous Candidiasis Overview Background Chronic mucocutaneous candidiasis (CMC) refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial infections of the skin, mucous membranes, and nails with Candida organisms, usually Candida albicans. These disorders are confined (...) P, Calvert JE, et al. Deregulated production of protective cytokines in response to Candida albicans infection in patients with chronic mucocutaneous candidiasis. Infect Immun . 2003 Oct. 71(10):5690-9. . van de Veerdonk FL, Plantinga TS, Hoischen A, et al. STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. N Engl J Med . 2011 Jul 7. 365(1):54-61. . Al Rushood M, McCusker C, Mazer B, Alizadehfar R, Grimbacher B, Depner M, et al. Autosomal Dominant Cases of Chronic

2014 eMedicine.com

66. Candidiasis (Overview)

A Hidalgo, MD; Chief Editor: Michael Stuart Bronze, MD Share Email Print Feedback Close Sections Sections Candidiasis Overview Practice Essentials Candidiasis (see the image below) is a fungal infection caused by yeasts from the genus Candida . Candida albicans is the predominant cause of the disease. Soreness and cracks at the lateral angles of the mouth (angular cheilitis) are a frequent expression of candidiasis in elderly individuals. Courtesy of Matthew C. Lambiase, DO. Signs and symptoms Chronic (...) fluconazole can be used [ ] Candida cystitis - In noncatheterized patients, Candida cystitis should be treated with fluconazole; in catheterized patients, the Foley catheter should be removed or replaced; if the candiduria persists after the catheter change, then patients can be treated with fluconazole See and for more detail. Next: Background Candidiasis is caused by infection with species of the genus Candida, predominantly with Candida albicans. Candida species are ubiquitous fungi that represent

2014 eMedicine.com

67. Candidiasis (Treatment)

and triazole anti-fungal treatment of uncomplicated vulvovaginal candidiasis (thrush). Cochrane Database Syst Rev . 2007 Oct 17. CD002845. . Pappas PG, Rex JH, Lee J, et al. A prospective observational study of candidemia: epidemiology, therapy, and influences on mortality in hospitalized adult and pediatric patients. Clin Infect Dis . 2003 Sep 1. 37(5):634-43. . Yang YL. Virulence factors of Candida species. J Microbiol Immunol Infect . 2003 Dec. 36(4):223-8. . Pappas PG. Invasive candidiasis. Infect Dis (...) with extensive candidiasis. Courtesy of Matthew C. Lambiase, DO. Discrete superficial pustules developed within hours of birth on the hand of an otherwise healthy newborn. A potassium hydroxide preparation revealed spores and pseudomycelium, and culture demonstrated the presence of Candida albicans. Courtesy of Matthew C. Lambiase, DO. Dry, red, superficially scaly, pruritic macules and patches on the penis represent candidal balanitis. Courtesy of Matthew C. Lambiase, DO. White plaques are present

2014 eMedicine.com

68. Candidiasis, Chronic Mucocutaneous (Diagnosis)

> Chronic Mucocutaneous Candidiasis Updated: Apr 17, 2017 Author: Blanca Anais Estupiñan; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Chronic Mucocutaneous Candidiasis Overview Background Chronic mucocutaneous candidiasis (CMC) refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial infections of the skin, mucous membranes, and nails with Candida organisms, usually Candida albicans. These disorders are confined (...) P, Calvert JE, et al. Deregulated production of protective cytokines in response to Candida albicans infection in patients with chronic mucocutaneous candidiasis. Infect Immun . 2003 Oct. 71(10):5690-9. . van de Veerdonk FL, Plantinga TS, Hoischen A, et al. STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. N Engl J Med . 2011 Jul 7. 365(1):54-61. . Al Rushood M, McCusker C, Mazer B, Alizadehfar R, Grimbacher B, Depner M, et al. Autosomal Dominant Cases of Chronic

2014 eMedicine.com

69. Candidiasis (Diagnosis)

A Hidalgo, MD; Chief Editor: Michael Stuart Bronze, MD Share Email Print Feedback Close Sections Sections Candidiasis Overview Practice Essentials Candidiasis (see the image below) is a fungal infection caused by yeasts from the genus Candida . Candida albicans is the predominant cause of the disease. Soreness and cracks at the lateral angles of the mouth (angular cheilitis) are a frequent expression of candidiasis in elderly individuals. Courtesy of Matthew C. Lambiase, DO. Signs and symptoms Chronic (...) fluconazole can be used [ ] Candida cystitis - In noncatheterized patients, Candida cystitis should be treated with fluconazole; in catheterized patients, the Foley catheter should be removed or replaced; if the candiduria persists after the catheter change, then patients can be treated with fluconazole See and for more detail. Next: Background Candidiasis is caused by infection with species of the genus Candida, predominantly with Candida albicans. Candida species are ubiquitous fungi that represent

2014 eMedicine.com

70. Candidiasis (Treatment)

A, Ebell W. A prospective, multicenter study of caspofungin for the treatment of documented Candida or Aspergillus infections in pediatric patients. Pediatrics . 2009 Mar. 123(3):877-84. . Tsekoura M, Ioannidou M, Pana ZD, Haidich AB, Antachopoulos C, Iosifidis E, et al. Efficacy and Safety of Echinocandins for the Treatment of Invasive Candidiasis in Children: A Meta-analysis. Pediatr Infect Dis J . 2019 Jan. 38 (1):42-49. . Media Gallery Typical appearance of thrush. Note multiple white plaques (...) trials evaluated fluconazole prophylaxis in premature infants. The study reported that fluconazole prophylaxis reduced the odds of invasive candidiasis and death (odds ratios of 0.48 [95% CI, .30-.78]), invasive candidiasis (0.20 [95% CI, .08-.51]) and Candida colonization (0.28 [95% CI, .18-.41]) compared to the placebo. [ ] Previous References Crislip MA, Edwards JE Jr. Candidiasis. Infect Dis Clin North Am . 1989 Mar. 3(1):103-33. . Zaoutis TE, Prasad PA, Localio AR, Coffin SE, Bell LM, Walsh TJ

2014 eMedicine Pediatrics

71. Candidiasis (Overview)

Author: Sabah Kalyoussef, DO; Chief Editor: Russell W Steele, MD Share Email Print Feedback Close Sections Sections Pediatric Candidiasis Overview Background Candidal infections are extremely common (see the images below). Typical appearance of thrush. Note multiple white plaques on lips, gingivae, tongue, and palate. Candidal diaper dermatitis. Note satellite papules and involvement of intertriginous folds. Candida albicans is the most common cause of human candidal infections, [ ] but other (...) are immunocompromised may suffer from candidal esophagitis as well as thrush. Genitals Vaginal yeast infections affect nearly 75% of women. Male partners may develop balanitis or balanoposthitis. Individuals with chronic indwelling catheters are also predisposed to recurrent candidal infections. Systemic Candida organisms can cause severe systemic infections in immunocompromised patients, compared with benign cutaneous or localized infections in immunocompetent patients. Reports of systemic candidiasis are common

2014 eMedicine Pediatrics

72. Candidiasis (Follow-up)

to appropriately clean their infant's bottles and pacifiers while they are treated for thrush. Encourage asthma patients to rinse their mouth after using their corticosteroid inhaler. Keep hands dry; when wet work is unavoidable, use rubber gloves with cotton liners. Response is generally quite good to topical azoles. Cutaneous candidiasis may be prevented by keeping areas cool and dry and by using breathable fabrics (eg, cotton). Fluconazole is used extensively in patients with neutropenia, persons undergoing (...) of sytemic antifungal agents. Clin Infect Dis . 2006. 43:S28-39. du Vivier A, McKee PH, eds. Atlas of Clinical Dermatology . Philadelphia, Pa: WB Saunders; 1986. Elder ME. T-cell immunodeficiencies. Pediatr Clin North Am . 2000 Dec. 47(6):1253-74. . Elewski BE. Cutaneous mycoses in children. Br J Dermatol . 1996 Jun. 134 Suppl 46:7-11: discussion 37-8. . Fidel PL Jr, Vazquez JA, Sobel JD. Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans. Clin

2014 eMedicine Pediatrics

73. Candidiasis (Diagnosis)

Author: Sabah Kalyoussef, DO; Chief Editor: Russell W Steele, MD Share Email Print Feedback Close Sections Sections Pediatric Candidiasis Overview Background Candidal infections are extremely common (see the images below). Typical appearance of thrush. Note multiple white plaques on lips, gingivae, tongue, and palate. Candidal diaper dermatitis. Note satellite papules and involvement of intertriginous folds. Candida albicans is the most common cause of human candidal infections, [ ] but other (...) are immunocompromised may suffer from candidal esophagitis as well as thrush. Genitals Vaginal yeast infections affect nearly 75% of women. Male partners may develop balanitis or balanoposthitis. Individuals with chronic indwelling catheters are also predisposed to recurrent candidal infections. Systemic Candida organisms can cause severe systemic infections in immunocompromised patients, compared with benign cutaneous or localized infections in immunocompetent patients. Reports of systemic candidiasis are common

2014 eMedicine Pediatrics

74. Candidiasis (Follow-up)

on the hand of an otherwise healthy newborn. A potassium hydroxide preparation revealed spores and pseudomycelium, and culture demonstrated the presence of Candida albicans. Image courtesy of Matthew C Lambiase, DO. Candidiasis. Dry, red, superficially scaly, pruritic macules and patches on the penis represent candidal balanitis. Image courtesy of Matthew C Lambiase, DO. Candidiasis. White plaques are present on the buccal mucosa and the undersurface of the tongue and represent thrush. When wiped off (...) resources, see the ; ; and , as well as , , , and . Previous References Delaloye J, Calandra T. Invasive candidiasis as a cause of sepsis in the critically ill patient. Virulence . 2014 Jan 1. 5(1):161-9. . . Mayer FL, Wilson D, Hube B. Candida albicans pathogenicity mechanisms. Virulence . 2013 Feb 15. 4(2):119-28. . . Yapar N. Epidemiology and risk factors for invasive candidiasis. Ther Clin Risk Manag . 2014. 10:95-105. . . Falagas ME, Roussos N, Vardakas KZ. Relative frequency of albicans

2014 eMedicine Emergency Medicine

75. Reflectance confocal microscopy for cutaneous infections and infestations. (Full text)

Reflectance confocal microscopy for cutaneous infections and infestations. Reflectance confocal microscopy (RCM) is a high-resolution emerging imaging technique that allows non-invasive diagnosis of several cutaneous disorders. A systematic review of the literature on the use of RCM for the study of infections and infestations has been performed to evaluate the current use of this technique and its possible future applications in this field. RCM is particularly suitable for the identification (...) of Sarcoptes scabies, Demodex folliculorum, Ixodes, Dermatophytes and Candida species in the clinical practice and for the follow-up after treatment. The cytopathic effect of herpes simplex virus, varicella zoster virus and molluscipoxvirus is also detectable by this imaging technique even in a pre-vesicular stage. In addition, thanks to its non-invasiveness, RCM allows pathophysiological studies. © 2015 European Academy of Dermatology and Venereology.

2015 Journal of the European Academy of Dermatology and Venereology PubMed abstract

76. Clinical features of candidiasis in patients with inherited interleukin-12 receptor β1 deficiency. (Full text)

and outcome of candidiasis in these patients have not been described before, to our knowledge. We report here the clinical signs of candidiasis in 35 patients with IL-12Rβ1 deficiency.Most (n = 71) of the 76 episodes of candidiasis were mucocutaneous. Isolated oropharyngeal candidiasis (OPC) was the most common presentation (59 episodes, 34 patients) and was recurrent or persistent in 26 patients. Esophageal candidiasis (n = 7) was associated with proven OPC in 2 episodes, and cutaneous candidiasis (n = 2 (...) Clinical features of candidiasis in patients with inherited interleukin-12 receptor β1 deficiency. Interleukin 12Rβ1 (IL-12Rβ1)-deficient patients are prone to clinical disease caused by mycobacteria, Salmonella, and other intramacrophagic pathogens, probably because of impaired interleukin 12-dependent interferon γ production. About 25% of patients also display mucocutaneous candidiasis, probably owing to impaired interleukin 23-dependent interleukin 17 immunity. The clinical features

2013 Clinical Infectious Diseases PubMed abstract

77. Candidiasis

of the genus Candida; usually a superficial infection of the moist areas of the body and is generally caused by Candida albicans; includes chronic mucocutaneous candidiasis, cutaneous candidiasis, oral candidiasis (thrush), and monilial vaginitis. Concepts Disease or Syndrome ( T047 ) MSH ICD9 112.9, 112 ICD10 , SnomedCT 187005005 , 187024008 , 187478002 , 154403005 , 370520002 , 78048006 English Candidiases , Candidiasis , Moniliases , Moniliasis , CANDIDIASIS , MONILIASIS , Candidiasis, unspecified , [X (...) ]Candidiasis, unspecified , candidiasis , candidiasis (diagnosis) , Candida infections , Candidiasis site NOS , candidosis , Candidiasis [Disease/Finding] , candidal infection , candidal infections , monilial infection , thrush , candida infections , candidiases , candida infection , muguet , monilia infection , Candidiasis NOS (disorder) , [X]Candidiasis, unspecified (disorder) , Candida NOS , Monilial infection , Moniliasis monilia , Moniliasis NOS , Candidiasis of unspecified site , Monilia NOS

2015 FP Notebook

78. Immunological features in a case of chronic granulomatous candidiasis and its treatment with transfer factor (Full text)

Antigens Candida albicans immunology Candidiasis, Cutaneous etiology immunology therapy Cell Migration Inhibition Child Child, Preschool Chronic Disease DNA biosynthesis Dialysis Granuloma immunology Humans Hypersensitivity, Delayed immunology Immunity, Maternally-Acquired Leukocytes Lymphocyte Activation Lymphocytes Macrophages Male Monocytes immunology Skin Tests Tissue Extracts therapeutic use 1972 6 1 1972 6 1 0 1 1972 6 1 0 0 ppublish 4557179 PMC1553624 N Engl J Med. 1968 May 2;278(18):971-6 (...) Immunological features in a case of chronic granulomatous candidiasis and its treatment with transfer factor 4557179 1972 09 05 2018 11 13 0009-9104 11 2 1972 Jun Clinical and experimental immunology Clin. Exp. Immunol. Immunological features in a case of chronic granulomatous candidiasis and its treatment with transfer factor. 151-63 Valdimarsson H H Wood C B CB Hobbs J R JR Holt P J PJ eng Journal Article England Clin Exp Immunol 0057202 0009-9104 0 Antigens 0 Tissue Extracts 9007-49-2 DNA IM

1972 Clinical and experimental immunology PubMed abstract

79. Mucocutaneous candidiasis, anergy and a plasma inhibitor of cellular immunity: reversal after amphotericin B therapy (Full text)

7XU7A7DROE Amphotericin B VC2W18DGKR Thymidine IM Adult Amphotericin B therapeutic use Candida albicans immunology Candidiasis, Cutaneous blood drug therapy immunology Chronic Disease Female Humans Hypersensitivity, Delayed immunology Immunity, Cellular Lectins Leukocytes metabolism Lymphocytes Mitosis Skin Tests Thymidine metabolism Tritium 1971 11 1 1971 11 1 0 1 1971 11 1 0 0 ppublish 4947556 PMC1713066 Science. 1966 Jul 29;153(3735):545-7 5938778 Lancet. 1967 Sep 30;2(7518):688-93 4167097 Trans Assoc (...) Mucocutaneous candidiasis, anergy and a plasma inhibitor of cellular immunity: reversal after amphotericin B therapy 4947556 1972 06 17 2018 11 13 0009-9104 9 5 1971 Nov Clinical and experimental immunology Clin. Exp. Immunol. Mucocutaneous candidiasis, anergy and a plasma inhibitor of cellular immunity: reversal after amphotericin B therapy. 595-602 Paterson P Y PY Semo R R Blumenschein G G Swelstad J J eng Journal Article England Clin Exp Immunol 0057202 0009-9104 0 Lectins 10028-17-8 Tritium

1971 Clinical and experimental immunology PubMed abstract

80. Successful treatment of candidiasis with transfer factor. (Full text)

Successful treatment of candidiasis with transfer factor. 5031659 1972 08 08 2018 11 13 0007-1447 2 5811 1972 May 20 British medical journal Br Med J Successful treatment of candidiasis with transfer factor. 442-3 Pabst H F HF Swanson R R eng Journal Article England Br Med J 0372673 0007-1447 0 Antigens AIM IM Antigens Candidiasis, Cutaneous therapy Candidiasis, Oral therapy Child Female Humans Immunity, Cellular Immunity, Maternally-Acquired Immunization, Passive Injections, Intramuscular

1972 British medical journal PubMed abstract

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