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Cushing Response

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161. Neuroendocrine and Immune Response to Stress in Schizophrenia

Neuroendocrine and Immune Response to Stress in Schizophrenia Neuroendocrine and Immune Response to Stress in Schizophrenia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Neuroendocrine and Immune Response (...) to Stress in Schizophrenia (TSST) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01975584 Recruitment Status : Completed First Posted : November 4, 2013 Last Update Posted : July 13, 2018 Sponsor: University of Maryland Information provided by (Responsible Party): Deanna Kelly, University of Maryland

2013 Clinical Trials

162. ACTHAR for Acute Treatment of Rheumatoid Arthritis Patients With Inadequate Response to Methotrexate

ACTHAR for Acute Treatment of Rheumatoid Arthritis Patients With Inadequate Response to Methotrexate ACTHAR for Acute Treatment of Rheumatoid Arthritis Patients With Inadequate Response to Methotrexate - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. ACTHAR for Acute Treatment of Rheumatoid Arthritis Patients With Inadequate Response to Methotrexate The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01984268 Recruitment Status : Unknown Verified August 2016 by Richard C. Chou, Dartmouth-Hitchcock Medical

2013 Clinical Trials

163. Efficacy and Safety of LCZ696 Compared to Olmesartan in Essential Hypertensive Patients Not Responsive to Olmesartan

Efficacy and Safety of LCZ696 Compared to Olmesartan in Essential Hypertensive Patients Not Responsive to Olmesartan Efficacy and Safety of LCZ696 Compared to Olmesartan in Essential Hypertensive Patients Not Responsive to Olmesartan - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Efficacy and Safety of LCZ696 Compared to Olmesartan in Essential Hypertensive Patients Not Responsive to Olmesartan The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01876368 Recruitment Status : Completed First Posted : June

2013 Clinical Trials

164. Best African American Response to Asthma Drugs

Best African American Response to Asthma Drugs Best African American Response to Asthma Drugs - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Best African American Response to Asthma Drugs (BARD) The safety (...) and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01967173 Recruitment Status : Completed First Posted : October 22, 2013 Results First Posted : November 15, 2018 Last Update Posted : November 15, 2018 Sponsor: Milton S. Hershey Medical Center Collaborator: National Heart, Lung, and Blood Institute (NHLBI) Information

2013 Clinical Trials

165. Cushing's syndrome (Full text)

such as in the and around the neck, as well as in the axilla. Untreated Cushing's syndrome can lead to and increased . Cortisol can also exhibit activity in high concentrations, worsening the hypertension and leading to (common in ectopic ACTH secretion) and (increased Na+ ions concentration in plasma). Furthermore, excessive cortisol may lead to disturbances, opportunistic infections, and impaired wound healing related to cortisol's suppression of the immune and inflammatory responses. is also an issue in Cushing's (...) of glucocorticoid medication. Cushing's syndrome results from some derangement of the body's own system of secreting cortisol. Normally, is released from the when necessary to stimulate the release of cortisol from the . In pituitary Cushing's, a benign pituitary adenoma secretes ACTH. This is also known as Cushing's disease and is responsible for 70% of endogenous Cushing's syndrome. In adrenal Cushing's, excess cortisol is produced by adrenal gland tumors, hyperplastic adrenal glands, or adrenal glands

2012 Wikipedia PubMed

166. Cushing reflex

Cushing reflex Cushing reflex - Wikipedia Cushing reflex From Wikipedia, the free encyclopedia Cushing reflex (also referred to as the vasopressor response , the Cushing effect , the Cushing reaction , the Cushing phenomenon , the Cushing response , or Cushing's Law ) is a physiological nervous system response to increased (ICP) that results in of increased blood pressure, irregular breathing, and . It is usually seen in the terminal stages of acute and may indicate imminent . It can also (...) be indicative of insufficient to the brain ( ) as well as compression of . In response to rising intracranial pressure (ICP), respiratory cycles change in regularity and rate. Different patterns indicate a different location of the brain where the injury occurred. The increase in is exhibited as an increase in rate rather than depth of ventilation, so the Cushing reflex is often associated with slow, irregular breathing. As a result of the now defective regulation of heart rate and blood pressure

2012 Wikipedia

167. Aberrant expression of multiple hormone receptors in adrenocorticotropin-independent macronodular adrenal hyperplasia causing Cushing's Syndrome. (Full text)

Aberrant expression of multiple hormone receptors in adrenocorticotropin-independent macronodular adrenal hyperplasia causing Cushing's Syndrome. Aberrant adrenal expression of various hormone receptors has been identified in ACTH-independent macronodular adrenal hyperplasia (AIMAH) causing cortisol hypersecretion regulated by hormones other than ACTH. We aimed to determine aberrant expression of multiple hormone receptors in vivo and in vitro in adrenal tissue of a patient with AIMAH.The (...) design of the study includes clinical case description, and biochemical and immunohistochemical analysis to demonstrate aberrant expression of multiple hormone receptors in AIMAH.The subject of the study is a male diagnosed with Cushing's syndrome because of AIMAH. Directly after laparoscopic removal of the adrenals, adrenal tissue was incubated with and without test substances (ACTH, forskolin, arginine vasopressin (AVP), desmopressin, epinephrine, norepinephrine, purified human chorionic

2010 European Journal of Endocrinology PubMed

168. Aberrant cortisol regulations in bilateral macronodular adrenal hyperplasia: a frequent finding in a prospective study of 32 patients with overt or subclinical Cushing's syndrome. (Full text)

of aberrant regulations, in relation with the functional status.Thirty-two consecutive patients with AIMAH were prospectively studied: 10 had a Cushing's syndrome (CS), and 22 had a subclinical CS (SCS).A baseline endocrine evaluation was followed by an in vivo protocol in search of aberrant cortisol responses (seven provocative tests). An acute inhibition test with the somatostatin analog octreotide was also performed.At least one aberrant cortisol response was identified in 28 of 32 (87%) patients (...) Aberrant cortisol regulations in bilateral macronodular adrenal hyperplasia: a frequent finding in a prospective study of 32 patients with overt or subclinical Cushing's syndrome. ACTH-independent macronodular adrenal hyperplasia (AIMAH) is a rare and heterogeneous condition characterized by abnormal steroid production. Cortisol secretion can be regulated by aberrant hormone receptors.A large series of patients with AIMAH were evaluated to provide information on the prevalence and profile

2010 European Journal of Endocrinology PubMed

169. Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome

. Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome (AUSC) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT01246739 Recruitment Status : Recruiting First Posted : November 23, 2010 Last Update Posted (...) : March 29, 2019 See Sponsor: Region Skane Information provided by (Responsible Party): Region Skane Study Details Study Description Go to Brief Summary: Incidental findings of adrenal tumours,"incidentalomas", occur in 1-5 % in the general population and 10-25 % of these patients will exhibit biochemical mild hypercortisolism. Although the patients do not have clinical signs of classical Cushing's syndrome, they have an increased risk for hypertension, dyslipidemia, diabetes mellitus, osteoporosis

2010 Clinical Trials

170. Cortisol and Nutritional Sympathetic Responsiveness

Cortisol and Nutritional Sympathetic Responsiveness Cortisol and Nutritional Sympathetic Responsiveness - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cortisol and Nutritional Sympathetic Responsiveness (...) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01620684 Recruitment Status : Unknown Verified September 2014 by Nora E. Straznicky, Baker Heart Research Institute. Recruitment status was: Recruiting First Posted : June 15, 2012 Last Update Posted : September 9, 2014 Sponsor: Baker Heart Research

2012 Clinical Trials

171. Repeated Partial Sleep Deprivation to Augment SSRI Response in Depression

Repeated Partial Sleep Deprivation to Augment SSRI Response in Depression Repeated Partial Sleep Deprivation to Augment SSRI Response in Depression - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Repeated (...) Partial Sleep Deprivation to Augment SSRI Response in Depression The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01545843 Recruitment Status : Completed First Posted : March 7, 2012 Results First Posted : January 30, 2015 Last Update Posted : December 8, 2017 Sponsor: University of Michigan Information

2012 Clinical Trials

172. Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors (Full text)

Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors The hypothalamic-pituitary-adrenal (HPA) axis, which mediates the body's response to stress, is largely under GABAergic control. Here we demonstrate that corticotropin-releasing hormone (CRH) neurons are modulated by the stress-derived neurosteroid, tetrahydrodeoxycorticosterone (THDOC), acting on δ subunit-containing GABA(A) receptors (GABA(A)Rs). Under normal conditions (...) conditions. Interestingly, blocking neurosteroidogenesis with finasteride is sufficient to block the stress-induced elevations in corticosterone and prevent stress-induced anxiety-like behaviors in mice. These data demonstrate that positive feedback of neurosteroids onto CRH neurons is required to mount the physiological response to stress. Further, GABA(A)R δ subunit-containing receptors and phosphorylation of KCC2 residue Ser940 may be novel targets for control of the stress response, which has

2011 The Journal of Neuroscience PubMed

173. The Effect of Vitamin D Supplementation on Calcium Excretion in Thalassemia: a Dose Response Study

The Effect of Vitamin D Supplementation on Calcium Excretion in Thalassemia: a Dose Response Study The Effect of Vitamin D Supplementation on Calcium Excretion in Thalassemia: a Dose Response Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. The Effect of Vitamin D Supplementation on Calcium Excretion in Thalassemia: a Dose Response Study The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01323608 Recruitment Status : Unknown Verified April 2011 by Weill Medical College of Cornell University

2011 Clinical Trials

174. Effect of Oxytocin on Stress Response in Cocaine-dependent Individuals

. Subjects with Addison's disease, Cushing's disease or other diseases of the adrenal cortex likely to affect hormonal/neuroendocrine status. Subjects with a history of or current psychotic disorder or bipolar affective disorder as these may interfere with subjective measurements. Subjects with current major depressive disorder or post-traumatic stress disorder as these disorders are associated with characteristic changes in stress response. Subjects receiving synthetic glucocorticoid therapy, any (...) Effect of Oxytocin on Stress Response in Cocaine-dependent Individuals Effect of Oxytocin on Stress Response in Cocaine-dependent Individuals - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect

2011 Clinical Trials

175. Acute metabolic response to human growth hormone in different types of dwarfism. (Full text)

Acute metabolic response to human growth hormone in different types of dwarfism. 5339170 1967 09 03 2018 11 13 0007-1447 3 5559 1967 Jul 22 British medical journal Br Med J Acute metabolic response to human growth hormone in different types of dwarfism. 196-9 Melvin K E KE Wright A D AD Hartog M M Antcliff A C AC Copestake A M AM Fraser T R TR eng Clinical Trial Journal Article England Br Med J 0372673 0007-1447 0 Insulin 9002-72-6 Growth Hormone N762921K75 Nitrogen SY7Q814VUP Calcium (...) V27W9254FZ Cortisone AIM IM Adolescent Adult Aged Arthritis, Juvenile metabolism Asthma metabolism Blood Urea Nitrogen Body Weight Bone Development drug effects Calcium urine Carcinoma metabolism Child Clinical Trials as Topic Cortisone adverse effects Cushing Syndrome metabolism Dwarfism drug therapy metabolism Dwarfism, Pituitary metabolism Female Growth Hormone blood therapeutic use Humans Hypoglycemia metabolism Insulin Male Middle Aged Nitrogen urine Osteoporosis metabolism Turner Syndrome

1967 British medical journal PubMed

176. ALTERED RESPONSES OF NEUROSPORA CRASSA TO INHIBITING CONCENTRATIONS OF INDOLE (Full text)

ALTERED RESPONSES OF NEUROSPORA CRASSA TO INHIBITING CONCENTRATIONS OF INDOLE 16561804 2006 05 25 2018 12 01 0021-9193 58 4 1949 Oct Journal of bacteriology J. Bacteriol. ALTERED RESPONSES OF NEUROSPORA CRASSA TO INHIBITING CONCENTRATIONS OF INDOLE. 433-42 Cushing J E JE University of California, Santa Barbara College, Department of Biology, Santa Barbara, California. Schwartz M M Bennett R R eng Journal Article United States J Bacteriol 2985120R 0021-9193 0 Indoles 8724FJW4M5 indole OM Indoles

1949 Journal of bacteriology PubMed

177. Response to stress. (Full text)

Response to stress. 4319949 1970 12 21 2018 11 30 0007-1447 4 5728 1970 Oct 17 British medical journal Br Med J Response to stress. 176 Besser G M GM eng Journal Article England Br Med J 0372673 0007-1447 0 Insulin 9002-60-2 Adrenocorticotropic Hormone AIM IM Adrenocorticotropic Hormone metabolism Cushing Syndrome etiology metabolism Humans Hypoglycemia chemically induced Insulin Stress, Physiological metabolism 1970 10 17 1970 10 17 0 1 1970 10 17 0 0 ppublish 4319949 PMC1819921 Lancet. 1965

1970 British medical journal PubMed

178. II. The Similarity in the Response to Posterior Lobe Extract (Pituitrin) and to Pilocarpine When Injected into the Cerebral Ventricles (Full text)

II. The Similarity in the Response to Posterior Lobe Extract (Pituitrin) and to Pilocarpine When Injected into the Cerebral Ventricles 16577341 2006 06 01 2008 11 20 0027-8424 17 4 1931 Apr Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. II. The Similarity in the Response to Posterior Lobe Extract (Pituitrin) and to Pilocarpine When Injected into the Cerebral Ventricles. 171-7 Cushing H H Peter Bent Brigham Hospital and Harvard

1931 Proceedings of the National Academy of Sciences of the United States of America PubMed

179. V. The Counteractive Effect of Tribromethanol (Avertin) on the Stimulatory Response to Pituitrin Injected in the Ventricle (Full text)

V. The Counteractive Effect of Tribromethanol (Avertin) on the Stimulatory Response to Pituitrin Injected in the Ventricle 16577355 2006 06 01 2008 11 20 0027-8424 17 5 1931 May Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. V. The Counteractive Effect of Tribromethanol (Avertin) on the Stimulatory Response to Pituitrin Injected in the Ventricle. 248-53 Cushing H H Harvard Medical School and Peter Bent Brigham Hospital. eng Journal

1931 Proceedings of the National Academy of Sciences of the United States of America PubMed

180. Benralizumab (asthma) - Benefit assessment according to §35a Social Code Book V

contribution to the dossier assessment. However, the advisor was not involved in the actual preparation of the dossier assessment. The responsibility for the contents of the dossier assessment lies solely with IQWiG. IQWiG employees involved in the dossier assessment: ? Sascha Abbas ? Michaela Florina Kerekes ? Inga Overesch ? Regine Potthast ? Min Ripoll ? Anke Schulz ? Corinna ten Thoren ? Volker Vervölgyi Keywords: benralizumab, asthma, benefit assessment Extract of dossier assessment A18-11 Version1.0 (...) of inadequate treatment of severe asthma does not comply with an ACT in severe refractory eosinophilic asthma if the option for treatment escalation is still available. The therapeutic indication also comprises patients for whom there is no further escalation option for their ongoing treatment, however. c: OCS should only be used on a short-term basis and in their lowest effective dose. It should be ensured in the OCS treatment of asthma that the OCS dosage does not permanently exceed the Cushing threshold

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

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