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Cushing Response

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121. The role of Harvey Cushing and Walter Dandy in the evolution of modern neurosurgery in the Netherlands, illustrated by their correspondence. (PubMed)

Medical Archives in Baltimore) of Cushing and Dandy with their Dutch disciples. The correspondence provides a unique inside view into the minds of both neurosurgical giants. After the neurologist Bernard Brouwer had paved the way for sending the Dutch surgeon Ignaz Oljenick overseas, Cushing personally took the responsibility to train him (1927-1929). On his return to Amsterdam, Oljenick and Brouwer established the first neurosurgical department in the country. Encouraged by Oljenick's favorable (...) The role of Harvey Cushing and Walter Dandy in the evolution of modern neurosurgery in the Netherlands, illustrated by their correspondence. The development of modern neurosurgery in the Netherlands, which took place in the 1920s, was highly influenced by the personal involvement of both Harvey Cushing and Walter Dandy, each in his own way. For the present article, the authors consulted the correspondence (kept at the Cushing/Whitney Medical Library in New Haven and the Alan Mason Chesney

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2013 Journal of Neurosurgery

122. Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Patients With Ectopic Cushing Syndrome

studies (100). Please remove one or more studies before adding more. Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Patients With Ectopic Cushing Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov (...) Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Patients With Ectopic Cushing Syndrome Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Patients With Ectopic Cushing Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2013 Clinical Trials

123. Treatment for Endogenous Cushing's Syndrome

Outcome Measures Go to Primary Outcome Measures : Reduction in urinary free cortisol in patients with endogenous Cushing's Syndrome. [ Time Frame: 6 months of maintenance phase therapy without a prior dose increase during that phase ] The response to COR-003 is defined as mean UFC concentration ≤ULN following 6 months of maintenance phase therapy without a prior dose increase during that phase. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate (...) Treatment for Endogenous Cushing's Syndrome Treatment for Endogenous Cushing's Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment for Endogenous Cushing's Syndrome The safety and scientific

2013 Clinical Trials

124. Cushing's syndrome after intralesional triamcinolone acetonide: a systematic review of the literature and multinational survey. (PubMed)

responses from 9 countries were received.A total of 18 cases of Cushing's syndrome after intralesional TAC have been reported in the English world literature. Survey data reveals that at least 30% (25/84) of plastic surgeons exceed the recommended dosage of TAC and 47% (46/97) are not aware of Cushing's syndrome as a possible complication of intralesional TAC.Cushing's syndrome resulting from intralesional TAC has been reported multiple times in the literature. Published literature suggests that TAC (...) Cushing's syndrome after intralesional triamcinolone acetonide: a systematic review of the literature and multinational survey. Intralesional triamcinolone acetonide (TAC) is a well-established treatment for keloids and hypertrophic scars. The present text provides a systematic review of all previously reported cases of Cushing's syndrome resulting from intralesional TAC in an effort to discover whether an association exists between dosage or frequency of injection and the subsequent

2013 Burns : journal of the International Society for Burn Injuries

125. Mifepristone in Children With Refractory Cushing's Disease

Cushing's Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01925092 Recruitment Status : Withdrawn (Lack of enrollment) First Posted : August 19, 2013 Last Update Posted : August 4, 2014 Sponsor: Corcept Therapeutics Collaborator: Eunice Kennedy Shriver National Institute of Child Health and Human (...) Development (NICHD) Information provided by (Responsible Party): Corcept Therapeutics Study Details Study Description Go to Brief Summary: Study objectives are to obtain safety, pharmacokinetic, and pharmacodynamic data on the effect of mifepristone on glucose metabolism, body weight and the growth-hormone-IGF in children with refractory Cushing's disease. Condition or disease Intervention/treatment Phase Cushing's Disease Drug: mifepristone Phase 3 Detailed Description: The study is being done to examine

2013 Clinical Trials

126. Study of the Efficacy and Safety of Pasireotide s.c. +/- Cabergoline in Patients With Cushing's Disease

). Please remove one or more studies before adding more. Study of the Efficacy and Safety of Pasireotide s.c. +/- Cabergoline in Patients With Cushing's Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01915303 Recruitment Status : Active, not recruiting First Posted : August 2, 2013 Last Update (...) Posted : February 11, 2019 Sponsor: Novartis Pharmaceuticals Information provided by (Responsible Party): Novartis ( Novartis Pharmaceuticals ) Study Details Study Description Go to Brief Summary: This study is to assess whether pasireotide alone and combined with cabergoline will give reliefs on patients with recurrent, persistent and newly diagnosed Cushing's disease. The study will also assess study drug safety, the changes in Quality of Life and on clinical signs and symptoms of Cushing's disease

2013 Clinical Trials

127. Predictors of Mortality and Long-term Outcomes in Treated Cushing's Disease: A Study of 346 Patients. (PubMed)

Predictors of Mortality and Long-term Outcomes in Treated Cushing's Disease: A Study of 346 Patients. Active Cushing's disease (CD) confers a 4-fold increase in mortality and is associated with significant morbidities. Although excess mortality risk may persist even after CD treatment, predictors of risk in treated CD are not well understood.To identify predictors of mortality, cardiovascular (CV) disease, and recurrence after long-term follow-up among patients with treated CD.A retrospective (...) chart review was conducted to evaluate patients with CD who underwent transsphenoidal adenectomy with a single surgeon.Patients were categorized based on disease response after initial treatment. Cox proportional hazard models identified predictors of mortality, recurrence, and CV outcomes in the overall cohort and each subgroup.Three hundred forty-six subjects were included. Mean age was 39.9 years, and mean duration of follow-up was 6.3 years (range, 1 mo to 30 y). Duration of exposure to excess

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2013 Journal of Clinical Endocrinology and Metabolism

128. Effects of Animal Assisted Activity on Biobehavioral Stress Responses of Hospitalized Children: A Randomized Control Trial

Effects of Animal Assisted Activity on Biobehavioral Stress Responses of Hospitalized Children: A Randomized Control Trial Effects of Animal Assisted Activity on Biobehavioral Stress Responses of Hospitalized Children: A Randomized Control Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. Effects of Animal Assisted Activity on Biobehavioral Stress Responses of Hospitalized Children: A Randomized Control Trial The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03017027 Recruitment Status : Completed

2017 Clinical Trials

129. GLP-1 Response in Women With PCOS and Prediabetes

GLP-1 Response in Women With PCOS and Prediabetes GLP-1 Response in Women With PCOS and Prediabetes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. GLP-1 Response in Women With PCOS and Prediabetes (...) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03325569 Recruitment Status : Completed First Posted : October 30, 2017 Last Update Posted : October 30, 2017 Sponsor: University Medical Centre Ljubljana Information provided by (Responsible Party): Andrej Janez, University Medical Centre Ljubljana Study

2017 Clinical Trials

130. Systematic review of efficacy of medical treatment in Cushing's Disease

Systematic review of efficacy of medical treatment in Cushing's Disease Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect

2016 PROSPERO

131. The reliability of screening tests for Cushing's syndrome in patients with chronic renal failure: a systematic review

The reliability of screening tests for Cushing's syndrome in patients with chronic renal failure: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence

2016 PROSPERO

132. Outcome of Cushing's Disease following Transsphenoidal Surgery in a Single Center over 20 Years. (PubMed)

Outcome of Cushing's Disease following Transsphenoidal Surgery in a Single Center over 20 Years. Historically, Cushing's disease (CD) was associated with a 5-yr survival of just 50%. Although advances in CD management have seen mortality rates improve, outcome from transsphenoidal surgery (TSS), the current first-line treatment, varies significantly between centers.The aim of the study was to define outcome including mortality in a cohort of CD patients treated with TSS over 20 yr.We conducted (...) underwent TSS.Patients were subdivided into groups based on disease response after initial treatment. Mortality according to subgroup was also assessed.Median follow-up for clinical data was 4.6 yr. Three outcome groups were identified: cure, 72% (52 of 72); persistent disease, 17% (12 of 72); and disease recurrence, 11% (eight of 72). Median time to recurrence after initial remission was 2.1 yr (interquartile range, 1.3-3.1 yr). Mean follow-up for mortality was 10.9 yr. Thirteen of 80 patients had died

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2012 Journal of Clinical Endocrinology and Metabolism

133. Regulation of steroidogenesis in a primary pigmented nodular adrenocortical disease-associated adenoma leading to virilization and subclinical Cushing's syndrome. (PubMed)

of steroidogenesis in a case of PPNAD with virilization.A 33-year-old woman presented with primary infertility due to hyperandrogenism. Elevated levels of testosterone and subclinical ACTH-independent Cushing's syndrome led to the discovery of an adrenal tumor, which was diagnosed as PPNAD. In vivo evaluation of aberrantly expressed hormone receptors showed no steroid response to known stimuli. Genetic analysis revealed a PRKAR1A protein-truncating Q28X mutation. After adrenalectomy, steroid levels normalized (...) Regulation of steroidogenesis in a primary pigmented nodular adrenocortical disease-associated adenoma leading to virilization and subclinical Cushing's syndrome. Primary pigmented nodular adrenocortical disease (PPNAD) can lead to steroid hormone overproduction. Mutations in the cAMP protein kinase A regulatory subunit type 1A (PRKAR1A) are causative of PPNAD. Steroidogenesis in PPNAD can be modified through a local glucocorticoid feed-forward loop.Investigation of regulation

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2012 European Journal of Endocrinology

134. Bronchial Carcinoid Tumors Causing Cushing's Syndrome: More Aggressive Behavior and the Need for Early Diagnosis. (PubMed)

Bronchial Carcinoid Tumors Causing Cushing's Syndrome: More Aggressive Behavior and the Need for Early Diagnosis. The aim of this study was to revisit the characteristics and outcomes of adrenocorticotropin-secreting bronchial carcinoid tumor (BCT) responsible for Cushing's syndrome (CS).We conducted a single-institution retrospective review of 14 patients who underwent pulmonary resection for BCT that presented as CS from October 1993 to November 2011.The group consisted of 8 male patients (57

2012 Annals of Thoracic Surgery

135. An Open-label, Multi-center, Expanded Access Study of Pasireotide s.c. in Patients With Cushing's Disease

). Please remove one or more studies before adding more. An Open-label, Multi-center, Expanded Access Study of Pasireotide s.c. in Patients With Cushing's Disease. (SEASCAPE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01582061 Recruitment Status : Completed First Posted : April 20, 2012 Results (...) First Posted : June 19, 2018 Last Update Posted : June 19, 2018 Sponsor: Novartis Pharmaceuticals Information provided by (Responsible Party): Novartis ( Novartis Pharmaceuticals ) Study Details Study Description Go to Brief Summary: This study provided access to pasireotide sc in patients with Cushing's disease.and provided additional information for safety and efficacy of pasireotide s.c. Condition or disease Intervention/treatment Phase Cushing's Disease Drug: Pasireotide sub-cutaneous Phase 3

2012 Clinical Trials

136. Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome

more. Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome (LIPOCUSH) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01688349 Recruitment Status : Completed First Posted : September 19, 2012 Last Update Posted : March 22, 2017 Sponsor: Assistance Publique - Hôpitaux de (...) Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2012 Clinical Trials

137. The Postoperative Basal Cortisol and CRH Tests for Prediction of Long-Term Remission from Cushing's Disease after Transsphenoidal Surgery. (PubMed)

The Postoperative Basal Cortisol and CRH Tests for Prediction of Long-Term Remission from Cushing's Disease after Transsphenoidal Surgery. Selective adenomectomy via transsphenoidal surgery induces remission of Cushing's disease (CD) in most patients. Although an undetectable postoperative serum cortisol (<2 μg/dl) has been advocated as an index of remission, there is no consensus on predictors of recurrence.We hypothesized that patients with subnormal cortisol (2-4.9 μg/dl) might achieve long (...) -term remission and that postoperative responses to CRH might predict recurrence.We prospectively studied CD patients with initial remission after adenomectomy or hemihypophysectomy (n = 14). Long-term recurrence (n = 39) or remission (n = 293) was assigned by laboratory results, glucocorticoid dependence, or patient survey at a mean of 10.6 yr after surgery.Postoperatively, morning cortisol was measured on d 3-5, and cortisol and ACTH responses to ovine CRH were assessed around d 10.Follow-up

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2011 Journal of Clinical Endocrinology and Metabolism

138. Cushing and the treatment of brain wounds during World War I. (PubMed)

at the time and eventually, for some, it was Cushing who was responsible for lowering the postoperative mortality rate of brain wounds during World War I. As the decades passed he was eventually credited as the "originator of brain wound care." This report shows that these attributions are misplaced. Cushing merely followed the enlightened surgical precepts of the time developed by Continental (European) surgeons. It also examines Cushing's writings to ascertain how these misperceptions concerning his (...) Cushing and the treatment of brain wounds during World War I. Harvey Cushing, perhaps the most important founder of American neurosurgery, was an Army neurosurgeon in France from 1917 to 1918. Over a 3-month period in 1917 he and his team operated on 133 soldiers with a brain wound. The operative mortality rate for their last 45 patients was 29%, considerably lower than the usual postoperative mortality rate of approximately 50% for those with a brain wound. This accomplishment was lauded

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2011 Journal of Neurosurgery

139. Sequential hormonal changes in 21 patients with recurrent Cushing's disease after successful pituitary surgery. (PubMed)

Sequential hormonal changes in 21 patients with recurrent Cushing's disease after successful pituitary surgery. To describe the sequence of hormonal changes during recurrence of Cushing's disease (CD) after successful transsphenoidal surgery (TSS).Retrospective study in a single center.We studied 101 of the 127 patients treated by TSS for CD between 1996 and 2009, who had hypocortisolism or eucortisolism for at least 3 months post-TSS. We arbitrarily defined 'overt recurrence', as presence (...) , median 43, range 7-94 vs mean 21.5 months, median 17, range 3-61, P=0.05), in patients with early post-TSS hypocortisolism compared with those with eucortisolism. Increase in midnight cortisol occurred in a mean time of 38.2 months, while UC elevation was observed at 50.6 months. Vasopressin analogs and CRH tests were eventually positive in 85 and 93% of all patients respectively; a positive response to one of the two dynamic tests preceded the increase in midnight cortisol or UC in 71 and 64

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2011 European Journal of Endocrinology

140. Endogenous ACTH Concentration-Cortisol Secretion Dose Analysis Unmasks Decreased ACTH Potency in Cushing's Disease with Restoration after Successful Pituitary Adenomectomy. (PubMed)

· min, vs. controls, 21 ± 2.3 nmol/liter · min (P <0.0001), and cured patients, 15 ± 3.2 nmol/liter · min (NS vs. controls)]. Sensitivity to endogenous ACTH did not differ among the three groups.The adrenal gland in Cushing's disease exhibits decreased responsiveness to submaximal ACTH drive and amplified efficacy, with unchanged sensitivity. These target-gland abnormalities are reversible in long-term remission after pituitary surgery. (...) Endogenous ACTH Concentration-Cortisol Secretion Dose Analysis Unmasks Decreased ACTH Potency in Cushing's Disease with Restoration after Successful Pituitary Adenomectomy. The relationship between circulating ACTH levels and cortisol secretion in Cushing's disease is not precisely known.Chronic ACTH hyperstimulation leads to decreased adrenal potency and is restored after normalization of ACTH secretion.Subjects included 20 patients with Cushing's disease, eight patients in long-term remission

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2011 Journal of Clinical Endocrinology and Metabolism

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