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Cushing Response

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101. High-resolution<sup>18</sup>F-fluorodeoxyglucose positron emission tomography and magnetic resonance imaging for pituitary adenoma detection in Cushing disease. Full Text available with Trip Pro

High-resolution18F-fluorodeoxyglucose positron emission tomography and magnetic resonance imaging for pituitary adenoma detection in Cushing disease. OBJECT High-resolution PET (hrPET) performed using a high-resolution research tomograph is reported as having a resolution of 2 mm and could be used to detect corticotroph adenomas through uptake of(18)F-fluorodeoxyglucose ((18)F-FDG). To determine the sensitivity of this imaging modality, the authors compared(18)F-FDG hrPET and MRI (...) detection of pituitary adenomas in Cushing disease (CD). METHODS Consecutive patients with CD who underwent preoperative(18)F-FDG hrPET and MRI (spin echo [SE] and spoiled gradient recalled [SPGR] sequences) were prospectively analyzed. Standardized uptake values (SUVs) were calculated from hrPET and were compared with MRI findings. Imaging findings were correlated to operative and histological findings. RESULTS Ten patients (7 females and 3 males) were included (mean age 30.8 ± 19.3 years; range 11-59

2014 Journal of Neurosurgery

102. Case report: nocardia infection associated with ectopic cushings. Full Text available with Trip Pro

Case report: nocardia infection associated with ectopic cushings. Cushing's syndrome results from exposure to excess glucocorticoids. Ectopic Cushings is endogenous ACTH dependant form of Cushing's associated with markedly raised ACTH and cortisol levels. This leads to an impaired immune response, setting the stage for occurrence of opportunistic infections. Nocardiosis is a gram positive bacterial infection caused by aerobic actinomycetes in genus Nocardia. We report a series of patients (...) diagnosed with ectopic Cushings, having pneumonia with Nocardia spp. In one of these cases, the manifestations of Cushing's disappeared with treatment for Nocardia.Two middle aged men of Asian descent presented to the Endocrine clinic: the first with history of exertional shortness of breath, and weight loss for 1 year, the other with facial swelling, disturbed sleep and lethargy for a month. The third case was a young Asian male who presented with progressive weakness & weight loss for 2 months. All

2014 BMC Endocrine Disorders

103. Prognostic impact of paraneoplastic cushing's syndrome in small-cell lung cancer. Full Text available with Trip Pro

Prognostic impact of paraneoplastic cushing's syndrome in small-cell lung cancer. Paraneoplastic Cushing's syndrome (CushingPS) in small-cell lung cancer is rare but severe.We studied 383 patients with small-cell lung cancer diagnosed between 1998 and 2012. Among them, 23 patients had CushingPS, 56 had other paraneoplastic syndrome (OtherPS), and 304 had no paraneoplastic syndrome (NoPS).After comparison of the three groups, we observed that CushingPS patients had more extensive disease: 82.6 (...) % versus 67.8% versus 53.3% (p = 0.005), respectively, with more than two metastatic sites: 63.2% versus 15.8% and 24.1% (p ≤ 0.001), a higher World Health Organization performance status (2-4): 73.9% versus 57.1% versus 43.7% (p = 0.006), greater weight loss (≥10%): 47.8% versus 33.9% versus 16.4% (p ≤ 0.001), reduced objective response to first-line treatment: 47.6% versus 74.1% versus 71.1% (p = 0.04), and poorer sensitivity to first-line treatment: 19% versus 38.9% versus 48.6% (p = 0.01). NoPS

2014 Journal of Thoracic Oncology

104. FGFR4 Polymorphic Variants Modulate Phenotypic Features of Cushing Disease. Full Text available with Trip Pro

FGFR4 Polymorphic Variants Modulate Phenotypic Features of Cushing Disease. Cushing disease is a potentially lethal condition resulting from hormone excess, usually due to a small pituitary tumor that fails to respond to negative feedback inhibition. A minority of patients develop larger, more aggressive tumors of the same lineage but with modest hormone excess. Here we show that a common polymorphism in the fibroblast growth factor receptor 4 (FGFR4) transmembrane domain yields receptor (...) isoforms with distinct properties that mediate these biological differences. Forced expression of the major FGFR4-G388 variant allele supports pY-signal transducer and activator of transcription (STAT3) responses. In contrast, expression of the minor FGFR4-R388 allele enhances STAT3 serine phosphorylation, driving cellular growth. In addition, FGFR4-R388 enhances glucocorticoid receptor phosphorylation and nuclear translocation. Consistent with these findings, glucocorticoid administration resulted

2014 Molecular Endocrinology

105. Pseudo-Cushing Syndrome (Diagnosis)

. . Bernini GP, Argenio GF, Cerri F, Franchi F. Comparison between the suppressive effects of dexamethasone and loperamide on cortisol and ACTH secretion in some pathological conditions. J Endocrinol Invest . 1994 Nov. 17 (10):799-804. . Malerbi DA, Fragoso MC, Vieira Filho AH, Brenlha EM, Mendonça BB. Cortisol and adrenocorticotropin response to desmopressin in women with Cushing's disease compared with depressive illness. J Clin Endocrinol Metab . 1996 Jun. 81 (6):2233-7. . Tirabassi G, Papa R, Faloia E (...) Pseudo-Cushing Syndrome (Diagnosis) Pseudo-Cushing Syndrome: Overview, Causes and Complications, History and Physical Examination Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI0NzE4LW92ZXJ2aWV3 processing

2014 eMedicine.com

106. Pseudo-Cushing Syndrome (Overview)

. . Bernini GP, Argenio GF, Cerri F, Franchi F. Comparison between the suppressive effects of dexamethasone and loperamide on cortisol and ACTH secretion in some pathological conditions. J Endocrinol Invest . 1994 Nov. 17 (10):799-804. . Malerbi DA, Fragoso MC, Vieira Filho AH, Brenlha EM, Mendonça BB. Cortisol and adrenocorticotropin response to desmopressin in women with Cushing's disease compared with depressive illness. J Clin Endocrinol Metab . 1996 Jun. 81 (6):2233-7. . Tirabassi G, Papa R, Faloia E (...) Pseudo-Cushing Syndrome (Overview) Pseudo-Cushing Syndrome: Overview, Causes and Complications, History and Physical Examination Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI0NzE4LW92ZXJ2aWV3 processing

2014 eMedicine.com

107. Cushing Syndrome (Overview)

activation, [ ] changes in the enzyme adenosine monophosphate-activated protein kinase activity, [ ] and modulation of activator protein 1 (Fos/Jun) [ ] are some of the important pathways that have been described. More research still needs to be conducted to fully understand the underlying signaling pathways and glucocorticoid tissue-specific responses. A study by Serfling et al suggested that weight gain in iatrogenic Cushing syndrome may be related to a glucocorticoid-stimulated rise in the amygdala (...) Cushing Syndrome (Overview) Iatrogenic Cushing Syndrome: Background, Frequency, Mortality/Morbidity Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE3MzY1LW92ZXJ2aWV3 processing > Iatrogenic Cushing Syndrome

2014 eMedicine.com

108. Pseudo-Cushing Syndrome (Treatment)

. . Bernini GP, Argenio GF, Cerri F, Franchi F. Comparison between the suppressive effects of dexamethasone and loperamide on cortisol and ACTH secretion in some pathological conditions. J Endocrinol Invest . 1994 Nov. 17 (10):799-804. . Malerbi DA, Fragoso MC, Vieira Filho AH, Brenlha EM, Mendonça BB. Cortisol and adrenocorticotropin response to desmopressin in women with Cushing's disease compared with depressive illness. J Clin Endocrinol Metab . 1996 Jun. 81 (6):2233-7. . Tirabassi G, Papa R, Faloia E (...) Pseudo-Cushing Syndrome (Treatment) Pseudo-Cushing Syndrome: Overview, Causes and Complications, History and Physical Examination Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI0NzE4LW92ZXJ2aWV3 processing

2014 eMedicine.com

109. Pseudo-Cushing Syndrome (Follow-up)

. . Bernini GP, Argenio GF, Cerri F, Franchi F. Comparison between the suppressive effects of dexamethasone and loperamide on cortisol and ACTH secretion in some pathological conditions. J Endocrinol Invest . 1994 Nov. 17 (10):799-804. . Malerbi DA, Fragoso MC, Vieira Filho AH, Brenlha EM, Mendonça BB. Cortisol and adrenocorticotropin response to desmopressin in women with Cushing's disease compared with depressive illness. J Clin Endocrinol Metab . 1996 Jun. 81 (6):2233-7. . Tirabassi G, Papa R, Faloia E (...) Pseudo-Cushing Syndrome (Follow-up) Pseudo-Cushing Syndrome: Overview, Causes and Complications, History and Physical Examination Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI0NzE4LW92ZXJ2aWV3 processing

2014 eMedicine.com

110. Cushing Syndrome (Diagnosis)

activation, [ ] changes in the enzyme adenosine monophosphate-activated protein kinase activity, [ ] and modulation of activator protein 1 (Fos/Jun) [ ] are some of the important pathways that have been described. More research still needs to be conducted to fully understand the underlying signaling pathways and glucocorticoid tissue-specific responses. A study by Serfling et al suggested that weight gain in iatrogenic Cushing syndrome may be related to a glucocorticoid-stimulated rise in the amygdala (...) Cushing Syndrome (Diagnosis) Iatrogenic Cushing Syndrome: Background, Frequency, Mortality/Morbidity Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE3MzY1LW92ZXJ2aWV3 processing > Iatrogenic Cushing Syndrome

2014 eMedicine.com

111. Glucocorticoid Therapy and Cushing Syndrome (Follow-up)

Glucocorticoid Therapy and Cushing Syndrome (Follow-up) Glucocorticoid Therapy and Cushing Syndrome Follow-up: Further Outpatient Care, Inpatient & Outpatient Medications, Transfer Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTIxMDg2LWZvbGxvd3Vw processing > Glucocorticoid Therapy and Cushing Syndrome Follow-up Updated: Dec 11, 2015 Author: George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London); Chief Editor: Sasigarn A Bowden, MD Share Email Print Feedback Close Sections Sections Glucocorticoid Therapy and Cushing Syndrome Follow-up Further Outpatient Care Regular follow-up care is required for patients with Cushing syndrome (CS) who are receiving adrenal steroid replacement. Obtain a history of the number of illnesses, frequency

2014 eMedicine Pediatrics

112. Glucocorticoid Therapy and Cushing Syndrome (Treatment)

Glucocorticoid Therapy and Cushing Syndrome (Treatment) Glucocorticoid Therapy and Cushing Syndrome Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTIxMDg2LXRyZWF0bWVudA== processing > Glucocorticoid Therapy and Cushing Syndrome Treatment & Management Updated: Dec 11, 2015 Author: George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London); Chief Editor: Sasigarn A Bowden, MD Share Email Print Feedback Close Sections Sections Glucocorticoid Therapy and Cushing Syndrome Treatment Medical Care Treatment of Cushing syndrome involves identifying the underlying cause, whereas management of exogenous hypercortisolism involves optimization of glucocorticoid dose and route

2014 eMedicine Pediatrics

113. Glucocorticoid Therapy and Cushing Syndrome (Overview)

Glucocorticoid Therapy and Cushing Syndrome (Overview) Glucocorticoid Therapy and Cushing Syndrome: Background, Pathophysiology, Endogenous Cushing syndrome Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTIxMDg2LW92ZXJ2aWV3 processing > Glucocorticoid Therapy and Cushing Syndrome Updated: Dec 11, 2015 Author: George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London); Chief Editor: Sasigarn A Bowden, MD Share Email Print Feedback Close Sections Sections Glucocorticoid Therapy and Cushing Syndrome Overview Background Cushing syndrome (CS) takes its name from Harvey Cushing, who, in 1912, was one of the first physicians to report a patient affected with excessive glucocorticoid. [ ] More than 99% of cases of Cushing

2014 eMedicine Pediatrics

114. Glucocorticoid Therapy and Cushing Syndrome (Diagnosis)

Glucocorticoid Therapy and Cushing Syndrome (Diagnosis) Glucocorticoid Therapy and Cushing Syndrome: Background, Pathophysiology, Endogenous Cushing syndrome Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTIxMDg2LW92ZXJ2aWV3 processing > Glucocorticoid Therapy and Cushing Syndrome Updated: Dec 11, 2015 Author: George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London); Chief Editor: Sasigarn A Bowden, MD Share Email Print Feedback Close Sections Sections Glucocorticoid Therapy and Cushing Syndrome Overview Background Cushing syndrome (CS) takes its name from Harvey Cushing, who, in 1912, was one of the first physicians to report a patient affected with excessive glucocorticoid. [ ] More than 99% of cases of Cushing

2014 eMedicine Pediatrics

115. Efficacy and Neural Mediators of Response to Trauma Management Therapy for PTSD

Efficacy and Neural Mediators of Response to Trauma Management Therapy for PTSD Efficacy and Neural Mediators of Response to Trauma Management Therapy for PTSD - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Efficacy and Neural Mediators of Response to Trauma Management Therapy for PTSD The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03449576 Recruitment Status : Enrolling by invitation First Posted : February 28, 2018 Last Update Posted : January 16, 2019 Sponsor: VA Office of Research and Development

2018 Clinical Trials

116. Maintenance of Response After rTMS for Depression Using tDCS

Maintenance of Response After rTMS for Depression Using tDCS Maintenance of Response After rTMS for Depression Using tDCS - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Maintenance of Response After rTMS (...) for Depression Using tDCS (START) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03708159 Recruitment Status : Recruiting First Posted : October 17, 2018 Last Update Posted : October 17, 2018 See Sponsor: Centre for Addiction

2018 Clinical Trials

117. Androgen Responses to hCG and Ovarian Morphology in PCOS

Androgen Responses to hCG and Ovarian Morphology in PCOS Androgen Responses to hCG and Ovarian Morphology in PCOS - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Androgen Responses to hCG and Ovarian (...) Morphology in PCOS The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03489668 Recruitment Status : Recruiting First Posted : April 5, 2018 Last Update Posted : August 9, 2018 See Sponsor: Poznan University of Medical Sciences

2018 Clinical Trials

118. Diagnostic accuracy and comparison of BIPSS in response to lysine vasopressin and hCRH Full Text available with Trip Pro

Diagnostic accuracy and comparison of BIPSS in response to lysine vasopressin and hCRH Bilateral inferior petrosal sinus sampling (BIPSS) using hCRH is currently considered the 'gold standard' test for the differential diagnosis of ACTH-dependent Cushing's syndrome (CS). Vasopressin is more potent than CRH to stimulate ACTH secretion as shown in animal studies; however, no comparative data of its use are available during BIPSS.To study the diagnostic accuracy and comparison of hCRH and lysine (...) vasopressin (LVP) stimulation during BIPSS.29 patients (27-Cushing's disease, 2-ectopic CS; confirmed on histopathology) underwent BIPSS and were included for the study. Patients were randomized to receive hCRH, 5 U LVP or 10 U LVP during BIPSS for ACTH stimulation. BIPSS and contrast-enhanced magnetic resonance imaging (CEMRI) were compared with intra-operative findings of trans-sphenoidal surgery (TSS) for localization and lateralization of the ACTH source.BIPSS correctly localized the source of ACTH

2018 Endocrine connections Controlled trial quality: uncertain

119. Systematic review of efficacy of medical treatment in Cushing's Disease

Systematic review of efficacy of medical treatment in Cushing's Disease Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect

2016 PROSPERO

120. The reliability of screening tests for Cushing's syndrome in patients with chronic renal failure: a systematic review

The reliability of screening tests for Cushing's syndrome in patients with chronic renal failure: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence

2016 PROSPERO

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