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Cushing Response

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81. Targeted Therapy With Gefitinib in Patients With USP8-mutated Cushing's Disease

. Targeted Therapy With Gefitinib in Patients With USP8-mutated Cushing's Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02484755 Recruitment Status : Unknown Verified June 2015 by Zhaoyun Zhang, Huashan Hospital. Recruitment status was: Recruiting First Posted : June 30, 2015 Last Update Posted (...) : June 30, 2015 Sponsor: Huashan Hospital Information provided by (Responsible Party): Zhaoyun Zhang, Huashan Hospital Study Details Study Description Go to Brief Summary: The USP8 gene and its downstream target, epidermal growth factor receptor (EGFR), is a potential therapeutic target of Cushing disease. The EGFR inhibitor, Gefitinib, has been shown to reduce the production of ACTH both in vitro and in vivo, especially in USP8-mutated corticotrophin adenomas. The investigators hypothesize

2015 Clinical Trials

82. Cushing's Disease Complications

Cushing's Disease Complications Cushing's Disease Complications - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cushing's Disease Complications (COMPLICUSHING) The safety and scientific validity (...) of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02568982 Recruitment Status : Recruiting First Posted : October 6, 2015 Last Update Posted : March 19, 2018 See Sponsor: Assistance Publique - Hôpitaux de Paris Information provided by (Responsible Party): Assistance

2015 Clinical Trials

83. Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome Subjects

studies (100). Please remove one or more studies before adding more. Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome Subjects The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02574793 Recruitment Status : Completed First Posted : October 14, 2015 (...) Last Update Posted : January 23, 2018 Sponsor: Huashan Hospital Information provided by (Responsible Party): xiaolong zhao, Huashan Hospital Study Details Study Description Go to Brief Summary: Glucose fluctuations present not only in patients with diabetes mellitus but also in subjects with normal glucose tolerance or impaired glucose regulation. People with Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome are at risk of impaired glucose metabolism. Glycemic variability is poorly

2015 Clinical Trials

84. Assessment of Persistent Cognitive Impairment After Cure of Cushing's Disease

. Assessment of Persistent Cognitive Impairment After Cure of Cushing's Disease (MEMOCUSH) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02603653 Recruitment Status : Unknown Verified November 2015 by Institut National de la Santé Et de la Recherche Médicale, France. Recruitment status was: Not yet (...) recruiting First Posted : November 13, 2015 Last Update Posted : November 13, 2015 Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Information provided by (Responsible Party): Institut National de la Santé Et de la Recherche Médicale, France Study Details Study Description Go to Brief Summary: Cushing's disease is a state of chronic endogenous glucocorticoid excess. Cushing's disease is responsible for increased morbidity and mortality. Recent studies have pinpointed

2015 Clinical Trials

85. Adrenal Venous Sampling in Patients With Overt or Subclinical Cushings Syndrome, and Bilateral Adrenal Tumors

(100). Please remove one or more studies before adding more. Adrenal Venous Sampling in Patients With Overt or Subclinical Cushings Syndrome, and Bilateral Adrenal Tumors (AVS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier (...) : NCT02543697 Recruitment Status : Recruiting First Posted : September 7, 2015 Last Update Posted : September 8, 2016 See Sponsor: Haukeland University Hospital Information provided by (Responsible Party): Haukeland University Hospital Study Details Study Description Go to Brief Summary: Patients with tumors in both adrenal glands and slightly elevated cortisol (subclinical Cushings syndrome) are offered to go through an adrenal venous sampling to try to quantify if the overproduction of cortisol is from

2015 Clinical Trials

86. Long-Term Outcome of Bilateral Laparoscopic Adrenalectomy Measured by Disease-Specific Questionnaire in a Unique Group of Patients with Cushing's Syndrome. Full Text available with Trip Pro

used a disease-specific questionnaire covering all major clinicopathologic characteristics of CS. We compared the outcome from LBA to a control group of 60 patients who had thyroidectomy (matched for age, gender, and time of surgery, 2:1 control-to-CS).Twenty-eight patients (20 women and 8 men) underwent LBA for CS. Of them, 24 patients (86 %) provided responses to our questionnaire. Ninety-two percent of patients' responses indicated a significant improvement of general Cushing's physical features (...) Long-Term Outcome of Bilateral Laparoscopic Adrenalectomy Measured by Disease-Specific Questionnaire in a Unique Group of Patients with Cushing's Syndrome. Laparoscopic bilateral adrenalectomy (LBA) is recommended for patients with bilateral adrenal disease and occult or unresectable ectopic Cushing's syndrome (CS). There are limited data on long-term outcomes after LBA, partly due to the lack of disease-specific tools for the measurement of impact on patients' health and quality of life.We

2015 Annals of Surgical Oncology

87. Variation in response to dexamethasone of a patient with Cushing's syndrome. Full Text available with Trip Pro

Variation in response to dexamethasone of a patient with Cushing's syndrome. A patient with Cushing's syndrome due to a nonresectable chromophobe adenoma underwent external irradiation of the hypothalamic-pituitary area. The signs of Cushing's syndrome ameliorated subsequently but recurred eventually, necessitating bilateral adrenalectomy 30 months after initial presentation. Response to dexamethasone suppression testing on four occasions varied greatly. These results may reflect alterations

1976 Canadian Medical Association Journal

88. Anomalous responses to stimulation and suppression tests in Cushing's syndrome due to a calcified adrenal adenoma Full Text available with Trip Pro

Anomalous responses to stimulation and suppression tests in Cushing's syndrome due to a calcified adrenal adenoma 4377169 1975 11 08 2018 11 13 0032-5473 49 578 1973 Dec Postgraduate medical journal Postgrad Med J Anomalous responses to stimulation and suppression tests in Cushing's syndrome due to a calcified adrenal adenoma. 923-6 Epstein S S Goldin A R AR McLaren E H EH eng Journal Article England Postgrad Med J 0234135 0032-5473 7S5I7G3JQL Dexamethasone 9002-60-2 Adrenocorticotropic Hormone (...) IM Adenoma complications Adrenal Gland Neoplasms complications Adrenal Glands drug effects Adrenocorticotropic Hormone pharmacology Adult Calcinosis complications Cushing Syndrome etiology Dexamethasone pharmacology Female Humans 1973 12 1 1973 12 1 0 1 1973 12 1 0 0 ppublish 4377169 PMC2495454 Am J Med. 1969 Oct;47(4):619-24 4309844 J Endocrinol. 1965 Nov;33(3):515-24 5845673 Br J Radiol. 1972 Aug;45(536):621-3 5045980 Metabolism. 1958 Sep;7(5):608-23 13577415 Acta Endocrinol (Copenh). 1964 Jun

1973 Postgraduate medical journal

89. CORRELATION OF PLASMA ACTH CONCENTRATION WITH ADRENOCORTICAL RESPONSE IN NORMAL HUMAN SUBJECTS, SURGICAL PATIENTS, AND PATIENTS WITH CUSHING'S DISEASE Full Text available with Trip Pro

CORRELATION OF PLASMA ACTH CONCENTRATION WITH ADRENOCORTICAL RESPONSE IN NORMAL HUMAN SUBJECTS, SURGICAL PATIENTS, AND PATIENTS WITH CUSHING'S DISEASE 14083159 1996 12 01 2018 12 01 0021-9738 42 1963 Nov The Journal of clinical investigation J. Clin. Invest. CORRELATION OF PLASMA ACTH CONCENTRATION WITH ADRENOCORTICAL RESPONSE IN NORMAL HUMAN SUBJECTS, SURGICAL PATIENTS, AND PATIENTS WITH CUSHING'S DISEASE. 1669-77 NEY R L RL SHIMIZU N N NICHOLSON W E WE ISLAND D P DP LIDDLE G W GW eng Journal (...) Article United States J Clin Invest 7802877 0021-9738 9002-60-2 Adrenocorticotropic Hormone OM Adrenocorticotropic Hormone Blood Chemical Analysis Cushing Syndrome Endocrinology Humans Pituitary ACTH Hypersecretion Pituitary-Adrenal Function Tests Surgical Procedures, Operative BLOOD CHEMICAL ANALYSIS CORTICOTROPIN CUSHING'S SYNDROME ENDOCRINOLOGY PITUITARY-ADRENAL FUNCTION TESTS SURGERY, OPERATIVE 1963 11 1 1963 11 1 0 1 1963 11 1 0 0 ppublish 14083159 10.1172/JCI104853 PMC289451 J Clin Invest. 1962

1963 Journal of Clinical Investigation

90. Long Term Safety and Efficacy of Pasireotide s.c. in Patients With Cushing's Disease

adding more. Long Term Safety and Efficacy of Pasireotide s.c. in Patients With Cushing's Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02310269 Recruitment Status : Recruiting First Posted : December 8, 2014 (...) Last Update Posted : August 20, 2018 See Sponsor: Novartis Pharmaceuticals Information provided by (Responsible Party): Novartis ( Novartis Pharmaceuticals ) Study Details Study Description Go to Brief Summary: This is a non-interventional, multinational, multi-center post-marketing study, to further document the safety and efficacy of pasireotide s.c. administered in routine clinical practice in patients with Cushing's disease. Patients with Cushing's disease and treated with pasireotide s.c

2014 Clinical Trials

91. Study of Management of Pasireotide-induced Hyperglycemia in Adult Patients With Cushing's Disease or Acromegaly

studies (100). Please remove one or more studies before adding more. Study of Management of Pasireotide-induced Hyperglycemia in Adult Patients With Cushing's Disease or Acromegaly The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02060383 Recruitment Status : Completed First Posted : February 12, 2014 (...) Last Update Posted : January 8, 2019 Sponsor: Novartis Pharmaceuticals Information provided by (Responsible Party): Novartis ( Novartis Pharmaceuticals ) Study Details Study Description Go to Brief Summary: The study aims to demonstrate that pasireotide-induced hyperglycemia can be effectively and safely managed in majority of patients, including those with diabetes at start of pasireotide treatment. Condition or disease Intervention/treatment Phase Cushing's Disease Acromegaly Drug: Pasireotide

2014 Clinical Trials

92. The Factors Associated With the Recurrence in Patients With Cushing Disease

. The Factors Associated With the Recurrence in Patients With Cushing Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02233335 Recruitment Status : Completed First Posted : September 8, 2014 Last Update Posted : September 8, 2014 Sponsor: National Taiwan University Hospital Information provided (...) by (Responsible Party): National Taiwan University Hospital Study Details Study Description Go to Brief Summary: Cushing syndrome refers the manifestations induced by chronic glucocorticoid excess and may arise from various causes. Iatrogenic Cushing syndrome accounts for most patients, when they are given exogenous glucocorticoid treatment. In contrast, spontaneous Cushing syndrome results from endogenous glucocorticoid over-secretion. Although Cushing disease is rare, it is the most common cause

2014 Clinical Trials

93. Cardiac Steatosis in Cushing's Syndrome

by (Responsible Party): Assistance Publique - Hôpitaux de Paris Study Details Study Description Go to Brief Summary: This study aims at evaluating the myocardial triglyceride content and cardiac structure and function, using 1H magnetic resonance spectroscopy and cardiac magnetic resonance imaging, in patients with Cushing's syndrome before and after treatment and in age-, sex- and BMI-matched healthy volunteers. The investigators make the hypothesis that Cushing's syndrome patients compared to healthy (...) Cardiac Steatosis in Cushing's Syndrome Cardiac Steatosis in Cushing's Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cardiac Steatosis in Cushing's Syndrome (CORTICOEUR) The safety and scientific

2014 Clinical Trials

94. Effects of Metyrapone in Patients With Endogenous Cushing's Syndrome

of Metyrapone in Patients With Endogenous Cushing's Syndrome (PROMPT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02297945 Recruitment Status : Unknown Verified February 2017 by HRA Pharma. Recruitment status was: Recruiting First Posted : November 21, 2014 Last Update Posted : February 15, 2017 Sponsor (...) : HRA Pharma Information provided by (Responsible Party): HRA Pharma Study Details Study Description Go to Brief Summary: The purpose of this prospective, international phase III/IV study is to assess the efficacy and safety of metyrapone in patients with endogenous Cushing's syndrome during up to 36 weeks of treatment. The ability of metyrapone (250 mg capsules) to normalize urinary free cortisol (UFC) levels will be assessed during up to 36 weeks (9 months) of treatment. Condition or disease

2014 Clinical Trials

95. Treatment of Cushing's Disease With R-roscovitine

provided by (Responsible Party): Shlomo Melmed, MD, Cedars-Sinai Medical Center Study Details Study Description Go to Brief Summary: The investigators hypothesize that R-roscovitine will suppress pituitary corticotroph tumor ACTH production and normalize urinary free cortisol levels in patients with Cushing disease. To date, R-roscovitine has been evaluated in several Phase I and II studies and has shown early signs of anti-cancer activity in approximately 240 patients. Condition or disease (...) Proceedings, Abs 2060. 2005. Yeo et al. J Clin Oncol 2009 27‐15s (Suppl abstr 6026). Layout table for additonal information Responsible Party: Shlomo Melmed, MD, Sr. Vice President of Academic Affairs, Cedars-Sinai Medical Center ClinicalTrials.gov Identifier: Other Study ID Numbers: Pro35720 First Posted: June 11, 2014 Last Update Posted: November 7, 2018 Last Verified: November 2018 Keywords provided by Shlomo Melmed, MD, Cedars-Sinai Medical Center: Cushings disease R-roscovitine Additional relevant

2014 Clinical Trials

96. Safety and Efficacy of LCI699 for the Treatment of Patients With Cushing's Disease

adding more. Safety and Efficacy of LCI699 for the Treatment of Patients With Cushing's Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02180217 Recruitment Status : Active, not recruiting First Posted : July 2, 2014 Last Update Posted : March 28, 2019 Sponsor: Novartis Pharmaceuticals (...) Information provided by (Responsible Party): Novartis ( Novartis Pharmaceuticals ) Study Details Study Description Go to Brief Summary: The study aims to confirm long-term efficacy and safety of LCI699 for the treatment of patients with Cushing's disease. It is a pivotal trial intended to support the registration of LCI699 for the treatment of patients with Cushing's disease in the EU, Japan, and other countries. This is a phase lll, multi-center, double-blind, randomized withdrawal study of LCI699

2014 Clinical Trials

97. Cushing's syndrome due to a bronchial ACTH-secreting carcinoid successfully treated with radio frequency ablation (RFA). Full Text available with Trip Pro

Cushing's syndrome due to a bronchial ACTH-secreting carcinoid successfully treated with radio frequency ablation (RFA). The ectopic production of ACTH is responsible for approximately 10% of cases of Cushing's syndrome. Whenever possible, once hypercortisolemia is under control with medical therapy, the final treatment consists of surgical excision of the tumor. We report a case of a patient with high surgical risk and poor response to medical therapy in which hypercortisolemia has been (...) successfully treated with radiofrequency ablation of the bronchial carcinoid tumor.A 43-year-old woman came to our hospital because of severe and rapidly worsening signs and symptoms of hypercortisolism over the previous 3 months. Hormonal tests suggested the presence of Cushing's syndrome due to ectopic ACTH production. Imaging studies detected an 8-mm pulmonary nodule with fluorine-18-fluorodeoxyglucose uptake localized in the middle right lobe. The patient started therapy with ketoconazole with poor

2014 Journal of Clinical Endocrinology and Metabolism

98. ACTH-secreting Pancreatic Neoplasms Associated With Cushing Syndrome: Clinicopathologic Study of 11 Cases and Review of the Literature. (Abstract)

ACTH-secreting Pancreatic Neoplasms Associated With Cushing Syndrome: Clinicopathologic Study of 11 Cases and Review of the Literature. Adrenocorticotropic hormone (ACTH)-secreting pancreatic neuroendocrine tumors (PanNETs), although rare, are responsible for about 15% of ectopic Cushing syndrome (CS). They represent a challenging entity because their preoperatory diagnosis is frequently difficult, and clear-cut morphologic criteria useful to differentiate them from other types of PanNETs have

2014 American Journal of Surgical Pathology

99. High-resolution<sup>18</sup>F-fluorodeoxyglucose positron emission tomography and magnetic resonance imaging for pituitary adenoma detection in Cushing disease. Full Text available with Trip Pro

High-resolution18F-fluorodeoxyglucose positron emission tomography and magnetic resonance imaging for pituitary adenoma detection in Cushing disease. OBJECT High-resolution PET (hrPET) performed using a high-resolution research tomograph is reported as having a resolution of 2 mm and could be used to detect corticotroph adenomas through uptake of(18)F-fluorodeoxyglucose ((18)F-FDG). To determine the sensitivity of this imaging modality, the authors compared(18)F-FDG hrPET and MRI (...) detection of pituitary adenomas in Cushing disease (CD). METHODS Consecutive patients with CD who underwent preoperative(18)F-FDG hrPET and MRI (spin echo [SE] and spoiled gradient recalled [SPGR] sequences) were prospectively analyzed. Standardized uptake values (SUVs) were calculated from hrPET and were compared with MRI findings. Imaging findings were correlated to operative and histological findings. RESULTS Ten patients (7 females and 3 males) were included (mean age 30.8 ± 19.3 years; range 11-59

2014 Journal of Neurosurgery

100. Case report: nocardia infection associated with ectopic cushings. Full Text available with Trip Pro

Case report: nocardia infection associated with ectopic cushings. Cushing's syndrome results from exposure to excess glucocorticoids. Ectopic Cushings is endogenous ACTH dependant form of Cushing's associated with markedly raised ACTH and cortisol levels. This leads to an impaired immune response, setting the stage for occurrence of opportunistic infections. Nocardiosis is a gram positive bacterial infection caused by aerobic actinomycetes in genus Nocardia. We report a series of patients (...) diagnosed with ectopic Cushings, having pneumonia with Nocardia spp. In one of these cases, the manifestations of Cushing's disappeared with treatment for Nocardia.Two middle aged men of Asian descent presented to the Endocrine clinic: the first with history of exertional shortness of breath, and weight loss for 1 year, the other with facial swelling, disturbed sleep and lethargy for a month. The third case was a young Asian male who presented with progressive weakness & weight loss for 2 months. All

2014 BMC Endocrine Disorders

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