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61. Exploring the Efficacy of a Safe Cryotherapy Alternative: Physiological Temperature Changes From Cold-Water Immersion Versus Prolonged Cooling of Phase-Change Material. Full Text available with Trip Pro

Exploring the Efficacy of a Safe Cryotherapy Alternative: Physiological Temperature Changes From Cold-Water Immersion Versus Prolonged Cooling of Phase-Change Material. To evaluate the effectiveness between cold-water immersion (CWI) and phase-change-material (PCM) cooling on intramuscular, core, and skin-temperature and cardiovascular responses.In a randomized, crossover design, 11 men completed 15 min of 15°C CWI to the umbilicus and 2-h recovery or 3 h of 15°C PCM covering the quadriceps

2019 International journal of sports physiology and performance Controlled trial quality: uncertain

62. Comparing the effects of shallomin lotion and cryotherapy on treating plane warts. Full Text available with Trip Pro

Comparing the effects of shallomin lotion and cryotherapy on treating plane warts. Wart is a common transferable skin disease that is caused by human papilloma virus. Choosing the best treatment method can vary based on age, therapeutic goal, complications, and wart place. Due to antibacterial effect of shallomin (hirtifolium Boiss extract) and since its effect has not been studied yet, it was compared to cryotherapy therapeutic methods for treating patients with plane warts.The present study (...) to cryotherapy, shallomin could not lead to a significant decrease in the size and number of warts.According to the results of this study, which is the first and the only investigation into the effects of shallomin on treating plane warts, it can be stated that despite of its antibacterial, antifungal, and anti-herpetic properties, shallamin cannot be a clinically effective option for treating plane warts.

2019 Journal of family medicine and primary care Controlled trial quality: uncertain

63. Cryotherapy as a Method for Relieving Symptoms of Cervical Ectopy: A Randomized Clinical Trial. Full Text available with Trip Pro

Cryotherapy as a Method for Relieving Symptoms of Cervical Ectopy: A Randomized Clinical Trial. Benign cervical ectopy (CE) may cause chronic or recurrent symptoms leading to women repeatedly being referred to gynecology clinics. We aimed to present a safe and effective method for relieving symptoms of CE.This double-blind clinical trial was conducted among 164 women with CE who complained of persistent or recurrent symptoms of cervicitis in the last six months. Patient's demographic data (...) , medical history, symptoms, and vaginal examination results were recorded. Normal co-test or Pap smear was required to enter the study. Participants were divided into two groups; the intervention group received cryotherapy and the control group underwent cryo-placebo (inserted the probe without true cryotherapy). The outcomes including improvement of symptoms and CE were monitored one, three, and six months later.The prevalence of symptoms in the two groups were not significantly different (p > 0.050

2019 Oman medical journal Controlled trial quality: uncertain

64. Effect of intra-canal cryotherapy on post-endodontic pain in single-visit RCT: A randomized controlled trial. Full Text available with Trip Pro

Effect of intra-canal cryotherapy on post-endodontic pain in single-visit RCT: A randomized controlled trial. To evaluate the effect of cold and room-temperature normal saline as a final irrigation on post-endodontic pain and to compare the post-endodontic pain level between the different protocols.A randomized controlled trial was conducted on 105 patients who underwent RCT and were distributed blindly and randomly into three equal groups (n = 35): Group 1, Cryotherapy group; Group 2, Room (...) of the canal with saline either cold or at room temperature was effective for post-endodontic pain control. This can be promising as an essential step in endodontic treatment to reduce post-endodontic pain. The room-temperature saline as final irrigation showed comparable results to intra-canal cryotherapy.

2019 The Saudi dental journal Controlled trial quality: uncertain

65. The effects of cryotherapy on quadriceps electromyographic activity and isometric strength in patient in the early phases following knee surgery. Full Text available with Trip Pro

The effects of cryotherapy on quadriceps electromyographic activity and isometric strength in patient in the early phases following knee surgery. To determine the effects of cryotherapy on quadriceps electromyographic (EMG) activity and isometric strength in early postoperative knee surgery patients.Twenty-two volunteers with recent knee surgeries were included. EMG readings of the vastus medialis (VM), rectus femoris (RF), and vastus lateralis (VL) from the surgical leg were collected during (...) their first test session.A 38% increase in VM EMG activity during QS and a 30% increase in maximum isometric knee extension strength were found after cryotherapy treatment. No significant differences were found in RF or VL EMG activity during QS after cryotherapy. No significant differences were found in any measurements after the sham treatment.Clinicians should consider applying ice to knee joints prior to exercise for patients following knee surgery with inhibited quadriceps.

2019 Journal of orthopaedic surgery (Hong Kong) Controlled trial quality: uncertain

66. The effectiveness of whole-body cryotherapy and physical exercises on the psychological well-being of patients with multiple sclerosis: A comparative analysis. Full Text available with Trip Pro

The effectiveness of whole-body cryotherapy and physical exercises on the psychological well-being of patients with multiple sclerosis: A comparative analysis. Due to the chronic character of multiple sclerosis (MS), non-pharmacological treatment can be applied. These therapies can be a good complementation to standard pharmacological treatment.The aim of the study was to evaluate the effectiveness of whole-body cryotherapy (WBC) and physical exercise training on the psychological and general (...) well-being of patients with MS.The study was carried out on 60 patients, who were divided into 3 groups: cryotherapy (Cryo), physical exercise training (Gym) and cryotherapy with physical exercise training (CryoGym). The Psychological General Well-Being Index, the Hospital Anxiety and Depression Scale and the Rivermead Mobility Index were used at 2 points in time: T1 - before the first therapy session and T2 - after 14 days of therapy.Statistically significant differences in the psychosocial well

2019 Advances in clinical and experimental medicine : official organ Wroclaw Medical University Controlled trial quality: uncertain

67. Limited Quality Evidence Suggests that Application of Cryotherapy May Be Helpful in Reducing Postoperative Pain in Root Canal Therapy in Patients With Symptomatic Apical Periodontitis. (Abstract)

Limited Quality Evidence Suggests that Application of Cryotherapy May Be Helpful in Reducing Postoperative Pain in Root Canal Therapy in Patients With Symptomatic Apical Periodontitis. Effects of Various Cryotherapy Applications on Postoperative Pain in Molar Teeth with Symptomatic Apical Periodontitis: A Preliminary Randomized Prospective Clinical Trial. Gundogdu EC, Arslan H. J Endod 2018:44(3):349-54.Not mentioned.Randomized controlled trial with parallel design.Copyright © 2019 Elsevier Inc

2019 Journal of Evidence Based Dental Practice Controlled trial quality: uncertain

68. Local ice cryotherapy decreases synovial interleukin 6, interleukin 1β, vascular endothelial growth factor, prostaglandin-E2, and nuclear factor kappa B p65 in human knee arthritis: a controlled study. Full Text available with Trip Pro

Local ice cryotherapy decreases synovial interleukin 6, interleukin 1β, vascular endothelial growth factor, prostaglandin-E2, and nuclear factor kappa B p65 in human knee arthritis: a controlled study. The aim of this study was to assess the anti-inflammatory effects of local cryotherapy in human non-septic knee arthritis.In the phase I of the study, patients were randomized to receive either ice (30 min; N = 16) or cold CO2 (2 min; N = 16) applied twice during 1 day at an 8-h interval (...) , 13 rheumatoid arthritides, 6 spondyloarthritides). Local ice cryotherapy significantly reduced the IL-6, IL-1β, VEGF, NF-kB-p65, and PG-E2 synovial levels, especially in the microcrystal-induced arthritis subgroup, while only phosphorylated NF-kB-p65 significantly decreased in rheumatoid arthritis and spondyloarthritis patients. Cold CO2 only reduced the synovial VEGF levels. In the phase II of the study, the synovial PG-E2 was significantly reduced in ice-treated knees, while it significantly

2019 Arthritis research & therapy Controlled trial quality: uncertain

69. Whole-body cryotherapy does not augment adaptations to high-intensity interval training. Full Text available with Trip Pro

Whole-body cryotherapy does not augment adaptations to high-intensity interval training. The aim of this study was to investigate the effects of regular post-exercise whole-body cryotherapy (WBC) on physiological and performance adaptations to high-intensity interval training (HIT). In a two-group parallel design, twenty-two well-trained males performed four weeks of cycling HIT, with each session immediately followed by 3 min of WBC (-110 °C) or a passive control (CON). To assess the effects

2019 Scientific reports Controlled trial quality: uncertain

70. [The Effects of Oral Cryotherapy on Oral Mucositis, Reactive Oxygen Series, Inflammatory Cytokines, and Oral Comfort in Gynecologic Cancer Patients Undergoing Chemotherapy: A Randomized Controlled Trial]. (Abstract)

[The Effects of Oral Cryotherapy on Oral Mucositis, Reactive Oxygen Series, Inflammatory Cytokines, and Oral Comfort in Gynecologic Cancer Patients Undergoing Chemotherapy: A Randomized Controlled Trial]. The purpose of this study was to examine the effects of oral cryotherapy on oral mucositis, reactive oxygen series, inflammatory cytokines, and oral comfort in patients undergoing chemotherapy for gynecologic cancers.Participants were randomly assigned to the experimental group (n=25 (...) , receiving oral cryotherapy during chemotherapy) and the control group (n=25, receiving the usual care consisting of 0.9% normal saline gargles three times before meals). Oral mucositis was assessed using the oral assessment guide, while oral comfort was assessed using the oral perception guide. Reactive oxygen series was measured as total oxidant stress, and the level of two inflammatory markers, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), were examined. The data were analyzed using t

2019 Journal of Korean Academy of Nursing Controlled trial quality: uncertain

71. Cryotherapy reduces muscle hypertonia, but does not affect lower limb strength or gait kinematics post-stroke: a randomized controlled crossover study. (Abstract)

Cryotherapy reduces muscle hypertonia, but does not affect lower limb strength or gait kinematics post-stroke: a randomized controlled crossover study. Based on the premise that spasticity might affect gait post-stroke, cryotherapy is among the techniques used to temporarily reduce spasticity in neurological patients. This effective technique would enhance muscle performance, and ultimately, functional training, such as walking. However, understanding whether a decrease in spasticity level (...) , if any, would lead to improving muscle performance and gait parameters is not based on evidence and needs to be clarified.to investigate the immediate effects of cryotherapy, applied to spastic plantarflexor muscles of subjects post-stroke, on tonus level, torque generation capacity of plantarflexors and dorsiflexors, and angular/spatiotemporal gait parameters.Sixteen chronic hemiparetic subjects participated in this randomized controlled crossover study. Cryotherapy (ice pack) or Control (room

2019 Topics in stroke rehabilitation Controlled trial quality: uncertain

72. Physiological responses to partial-body cryotherapy performed during a concurrent strength and endurance session. Full Text available with Trip Pro

Physiological responses to partial-body cryotherapy performed during a concurrent strength and endurance session. This investigation examined the effect of partial-body cryostimulation (PBC) performed in the recovery time between a strength training and an interval running (IR) session. Nine rugby players (age, 23.7 ± 3.6 years; body mass index, 28.0 ± 2.6 kg·m-2) were randomly exposed to 2 different conditions: (i) PBC: 3 min at -160 °C, and (ii) passive recovery at 21 °C. We performed (...) , the BIA vector was restored close to normohydration status. Autonomic variables changed over time in both conditions, although the mean differences and effect sizes were greater in the PBC condition. During IR, HR was 3.5% lower after PBC, and the same result was observed for oxygen uptake (∼4.9% lower) and ventilation (∼6.5% lower). The energy cost measured after cryotherapy was ∼9.0% lower than after passive recovery. Cryotherapy enhances recovery after a single strength training session, and during

2019 Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme Controlled trial quality: uncertain

73. Whole body cryotherapy, cold water immersion, or a placebo following resistance exercise: a case of mind over matter? Full Text available with Trip Pro

Whole body cryotherapy, cold water immersion, or a placebo following resistance exercise: a case of mind over matter? The use of cryotherapy as a recovery intervention is prevalent amongst athletes. Performance of high volume, heavy load resistance exercise is known to result in disturbances of muscle function, perceptual responses and blood borne parameters. Therefore, this study investigated the influence of cold water immersion (CWI), whole body cryotherapy (WBC) or a placebo (PL (...) function, and increased inflammation and efflux of intracellular proteins. Although WBC attenuated soreness at 24 h, and positively influenced peak force at 48 h compared to CWI and PL, many of the remaining outcomes were trivial, unclear or favoured the PL condition. With the exception of CRP at 24 h, neither cryotherapy intervention attenuated the inflammatory response compared to PL.There was some evidence to suggest that WBC is more effective than CWI at attenuating select perceptual and functional

2019 European journal of applied physiology

74. Effect of intracanal cryotherapy on the fracture resistance of endodontically treated teeth. (Abstract)

Effect of intracanal cryotherapy on the fracture resistance of endodontically treated teeth. The aim of this study is to evaluate the effect of intracanal cryotherapy on the fracture resistance of endodontically treated teeth.Sixty single-rooted maxillary lateral incisor teeth with single root canals were selected and randomly divided into two groups (n = 30). The specimens were immersed in distilled water, which was heated to 37 °C during the procedures. The root canals were chemomechanically (...) prepared up to the apical size of 50 and assigned to either the control group or the cryotherapy group. The specimens in the cryotherapy group were irrigated with 20 mL sterile cold (2.5 °C) saline solution, which was delivered with an EndoVac system for 5 min, whereas the specimens in the control group received a sterile saline solution at room temperature. The fracture resistance of the specimens was then tested with a universal testing machine. The data was analyzed using the independent sample t

2019 Acta odontologica Scandinavica

75. Whole-body cryotherapy (-110 °C) following high-intensity intermittent exercise does not alter hormonal, inflammatory or muscle damage biomarkers in trained males. Full Text available with Trip Pro

Whole-body cryotherapy (-110 °C) following high-intensity intermittent exercise does not alter hormonal, inflammatory or muscle damage biomarkers in trained males. This study examined the acute effects of a single session of Whole-body Cryotherapy (WBC) following severe intermittent running exercise on biomarkers of inflammation, muscle damage and stress.Endurance-trained males (n = 11) were tested twice using a within-participant, balanced cross-over design that consisted of 5 × 5 min

2019 Cytokine Controlled trial quality: uncertain

76. Early-Medium-Term Outcomes of Primary Focal Cryotherapy to Treat Nonmetastatic Clinically Significant Prostate Cancer from a Prospective Multicentre Registry. Full Text available with Trip Pro

Early-Medium-Term Outcomes of Primary Focal Cryotherapy to Treat Nonmetastatic Clinically Significant Prostate Cancer from a Prospective Multicentre Registry. Focal cryotherapy can be used to treat patients with clinically significant nonmetastatic prostate cancer to reduce side effects.Early-medium-term cancer control and functional outcomes.A prospective registry-based case series of 122 consecutive patients undergoing focal cryotherapy between October 1, 2013, and November 30, 2016, in five (...) was 90.5% [95% confidence interval (CI) 84.2-97.3]. When stratified for the NCCN risk group, 3-yr outcomes were 84.7% (95% CI 71.4-100) in high risk and 93.3% (95% CI 86.8-100) in intermediate risk. At last follow-up, incontinence defined as any pad use was 0/69 (0%) and erectile dysfunction (defined as erections insufficient for penetration) was 5/31 (16.1%). Limitations include lack of long-term outcomes.Focal cryotherapy primarily for anterior intermediate and high-risk prostate cancer results

2019 European Urology

77. Cryotherapy Treatment After Unicompartmental and Total Knee Arthroplasty: A Review (Abstract)

Cryotherapy Treatment After Unicompartmental and Total Knee Arthroplasty: A Review Cryotherapy is widely utilized to enhance recovery after knee surgeries. However, the outcome parameters often vary between studies. Therefore, the purpose of this review is to compare (1) no cryotherapy vs cryotherapy; (2) cold pack cryotherapy vs continuous flow device cryotherapy; (3) various protocols of application of these cryotherapy methods; and (4) cost-benefit analysis in patients who had (...) unicompartmental knee arthroplasty (UKA) or total knee arthroplasty (TKA).A search for "knee" and "cryotherapy" using PubMed, EBSCO Host, and SCOPUS was performed, yielding 187 initial reports. After selecting for RCTs relevant to our study, 16 studies were included.Of the 8 studies that compared the immediate postoperative outcomes between patients who did and did not receive cryotherapy, 5 studies favored cryotherapy (2 cold packs and 3 continuous cold flow devices). Of the 6 studies comparing the use

2017 EvidenceUpdates

78. The topical treatment of old world cutaneous leishmaniasis with gentian violet along with cryotherapy: a pilot single-blind randomized controlled clinical trial. Full Text available with Trip Pro

The topical treatment of old world cutaneous leishmaniasis with gentian violet along with cryotherapy: a pilot single-blind randomized controlled clinical trial. The promising non-clinical antileishmanial effects of gentian violet (GV) encouraged us to evaluate the additive effect of GV on cryotherapy.For 8 weeks, 59/161 cutaneous leishmaniasis patients/lesions underwent cryotherapy alone (group 1) or cryotherapy accompanied by 1% GV application (group 2). The primary endpoint was clinical (...) response.Ultimately, 54.7% and 45.3% of the significantly cured lesions belonged to groups 1 and 2, respectively, which was not statistically significant. The clinical response was significantly different between the two groups at the end of the fourth week.Although the clinical response of the two groups was significantly different at the end of the fourth week, application of GV did not increase the efficacy of cryotherapy.

2019 Revista da Sociedade Brasileira de Medicina Tropical Controlled trial quality: uncertain

79. Cryotherapy as prophylaxis against oral mucositis after high-dose melphalan and autologous stem cell transplantation for myeloma: a randomised, open-label, phase 3, non-inferiority trial. (Abstract)

Cryotherapy as prophylaxis against oral mucositis after high-dose melphalan and autologous stem cell transplantation for myeloma: a randomised, open-label, phase 3, non-inferiority trial. The conditioning therapy used in connection with haematopoietic stem cell transplantation (HSCT) can induce painful oral mucositis, which has negative impacts on patient quality of life and survival, as well as on health-care costs. While cooling of the oral mucosa (cryotherapy) is regarded as standard (...) prophylaxis against oral mucositis, the long duration of the treatment affects compliance owing to side effects. In this prospective, randomised trial, 94 patients (62 males/32 females; median age 59 years, range 34-69) with a diagnosis of myeloma who were undergoing autologous HSCT were randomised 1:1 to receive cryotherapy for 7 h (N = 46) or 2 h (N = 48). Oral mucositis was evaluated prospectively. No significant difference was observed with respect to the proportion of patients who showed grades 3

2019 Bone marrow transplantation Controlled trial quality: uncertain

80. Fabrication of Laser-reduced Graphene Oxide in Liquid Nitrogen Environment Full Text available with Trip Pro

Fabrication of Laser-reduced Graphene Oxide in Liquid Nitrogen Environment Porous structure of reduced graphene oxide (rGO) plays an important role in developing flexible graphene-based devices. In this work, we report a novel methodology for reduction of freestanding graphite oxide (GO) sheet by picosecond pulse laser direct writing in liquid nitrogen. Non-agglomerate and porous structure of rGO is fabricated successfully due to frozen effect during laser processing. Compared with laser (...) -irradiated rGO developed in N2 gas at ambient environment, the frozen rGO developed in liquid N2 shows better ordered structure with less defects, crack-free morphology as well as better electron supercapacitor performance including 50-60 Ω/sq in sheet electrical resistance. Mechanism of cryotemperature photoreduction GO is also discussed.

2016 Scientific reports

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