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181. Could −79 °C Spray-Type Cryotherapy Be an Effective Monotherapy for the Treatment of Keloid? Full Text available with Trip Pro

Could −79 °C Spray-Type Cryotherapy Be an Effective Monotherapy for the Treatment of Keloid? Cryotherapy has been regarded as an effective modality for the treatment of keloids, and the spray-type device is one of the novel cryotherapeutic units. However, the biological mechanisms and therapeutic effects of this technique are incompletely studied. We evaluated the clinical efficacy of our cryotherapy protocol with molecular and pathologic evidence for the treatment of keloids. We evenly (...) split each of ten keloid lesions into a non-treated (C-) and treated (C+) area; the C+ area was subjected to two freeze-thaw cycles of spray-type cryotherapy using -79 °C spray-type CryoPen™. This treatment was repeated after an interval of two weeks. The proliferation and migration abilities of the fibroblasts isolated from the dermis under the cryotherapy-treated or untreated keloid tissues (at least 5 mm deep) were compared and pathologic findings of the full layer were evaluated. Molecular

2017 International journal of molecular sciences

182. Efficacy and Safety of Three Cryotherapy Devices for Wart Treatment: A Randomized, Controlled, Investigator-Blinded, Comparative Study Full Text available with Trip Pro

Efficacy and Safety of Three Cryotherapy Devices for Wart Treatment: A Randomized, Controlled, Investigator-Blinded, Comparative Study Cutaneous warts are common skin lesions, caused by human papillomavirus. For years, liquid nitrogen is the cryogen of choice for wart treatment. Alternatively, several cryogenic devices for home treatment are commercially available. The present trial assessed efficacy and safety of a novel nitrous oxide-based cryogenic device for home use (EndWarts Freeze® (...) %). Reported side effects were transient and typical of cryotherapy. All treatments were well-tolerated.The superior cure rates for the test product versus two comparators can be explained by its design. Combination of nitrous oxide (cooling agent), the specific activation method (holding the liquid coolant in the cap), and skin-conforming polyurethane foam, results in higher cooling efficiency (- 80 °C) and more effective wart freezing. This trial demonstrated that the nitrous oxide device is a safe, user

2017 Dermatology and therapy Controlled trial quality: uncertain

183. Patient-reported quality of life progression in men with prostate cancer following primary cryotherapy, cyberknife, or active holistic surveillance. Full Text available with Trip Pro

Patient-reported quality of life progression in men with prostate cancer following primary cryotherapy, cyberknife, or active holistic surveillance. Technological advancements have led to the success of minimally invasive treatment modalities for prostate cancer such as CyberKnife and Cryotherapy. Here, we investigate patient-reported urinary function, bowel habits, and sexual function in patients following CyberKnife (CK) or Cryotherapy treatment, and compare them with active holistic (...) surveillance (AHS) patients.An IRB-approved institutional database was retrospectively reviewed for patients who underwent CK, Cryotherapy, or AHS. Quality of life (QoL) survey responses were collected every three months and the mean function scores were analyzed in yearly intervals over the 4 years post-treatment.279 patients (767 survey sets) were included in the study. There was no difference among groups in urinary function scores. The CyberKnife group had significantly lower bowel habit scores

2017 Prostate cancer and prostatic diseases

184. Transperineal cryotherapy for unresectable muscle invasive bladder cancer: preliminary experience with 7 male patients. Full Text available with Trip Pro

Transperineal cryotherapy for unresectable muscle invasive bladder cancer: preliminary experience with 7 male patients. Radical cystectomy (RC) with pelvic lymph node dissection (PLND) and urinary diversion (UD) is considered the standard treatment for muscle invasive bladder cancer (MIBC). In a part of patients, RC procedure is aborted due to unresectable disease, other followed treatment like systemic chemotherapy, radiotherapy or cryotherapy may be a better option. The aim of present study (...) was to report the preliminary results of transperineal cryotherapy for unresectable muscle invasive bladder cancer.From January 2011 to August 2013, 7 male patients with pT4b unresectable bladder cancer underwent bilateral ureterocutaneostomy. Two performed a pelvic lymph node dissection (PLND). Then primary transperineal cryosurgery for preserved bladder at the guidance of transrectal ultrasound (TRUS) was performed. All patients underwent a dual freeze-thaw cycle using third-generation cryotechnology

2017 BMC Urology

185. Nitrous oxide cryotherapy for treatment of esophageal squamous cell neoplasia: initial multicenter international experience with a novel portable cryoballoon ablation system (with video). (Abstract)

Nitrous oxide cryotherapy for treatment of esophageal squamous cell neoplasia: initial multicenter international experience with a novel portable cryoballoon ablation system (with video). Early esophageal squamous cell neoplasia (ESCN) can be successfully treated by EMR, endoscopic submucosal dissection (ESD), or radiofrequency ablation. A new portable, battery-powered cryotherapy system using nitrous oxide (cryoballoon focal ablation system [CbFAS]) has been used for Barrett's esophagus (...) . It consists of a small hand-held device containing liquid nitrous oxide, which converts to gas within a low-pressure-compliant through-the-scope balloon and freezes targeted mucosa in contact with the balloon. This study evaluated the feasibility of endoscopic eradication of early ESCN with the CbFAS.Patients with early ESCN (defined as low-grade intraepithelial neoplasia [LGIN], high-grade intraepithelial neoplasia [HGIN], or early T1 squamous mucosal cancer) were treated with the CbFAS. After

2017 Gastrointestinal endoscopy

186. PSA kinetics following primary focal cryotherapy (hemiablation) in organ-confined prostate cancer patients. (Abstract)

PSA kinetics following primary focal cryotherapy (hemiablation) in organ-confined prostate cancer patients. We aim to evaluate prostate-specific antigen (PSA) trends in post-primary focal cryotherapy (PFC) patients.This was an institutional review board-approved retrospective study of PFC patients from 2010 to 2015. Patients with at least one post-PFC PSA were included in the study. Biochemical recurrence (BCR) was determined using the Phoenix criteria. PSA bounce was also assessed. We analyzed (...) compared to those who do not recur. Nadir PSA of less than 2 ng/ml may be considered the new normal PSA in focal cryotherapy (hemiablation) follow-up.

2017 World journal of urology

187. Increased Cervical HIV RNA Shedding Among HIV-Infected Women Randomized to Loop Electrosurgical Excision Procedure (LEEP) compared to Cryotherapy for Cervical Intraepithelial Neoplasia 2/3. Full Text available with Trip Pro

Increased Cervical HIV RNA Shedding Among HIV-Infected Women Randomized to Loop Electrosurgical Excision Procedure (LEEP) compared to Cryotherapy for Cervical Intraepithelial Neoplasia 2/3. Treatment of human immunodeficiency virus (HIV)-infected women to prevent cervical cancer may stimulate HIV RNA cervical shedding and risk HIV transmission.From 2011 to 2014, 400 HIV-infected women diagnosed with cervical intraepithelial neoplasia 2/3 in Kenya were randomized to loop electrosurgical excision (...) procedure (LEEP) or cryotherapy. Cervical samples were collected at baseline and 3 weekly intervals. Samples were tested for HIV RNA using the Gen-Probe Aptima HIV assay with a minimum detection level of 60 copies/swab and analyzed using generalized estimating equations.Women who received LEEP had significantly higher cervical HIV RNA levels than those who received cryotherapy at weeks 2 (adjusted incident rate ratio [aIRR], 1.07; P = .038) and 3 (aIRR, 1.08; P = .046). Within LEEP, significantly higher

2017 Clinical Infectious Diseases Controlled trial quality: uncertain

188. Effects of Focal Versus Total Cryotherapy and Minimum Tumor Temperature on Patient-Reported Quality of Life as Compared to Active Surveillance in Prostate Cancer Patients. Full Text available with Trip Pro

Effects of Focal Versus Total Cryotherapy and Minimum Tumor Temperature on Patient-Reported Quality of Life as Compared to Active Surveillance in Prostate Cancer Patients. To investigate the effects of focal (hemiablation) or total cryotherapy and minimum tumor temperature on patient-reported quality of life (QoL) in patients with prostate cancer.An Institutional Review Board-approved database was reviewed for patients who underwent cryotherapy or active surveillance (AS). QoL questionnaire (...) responses were collected and scores were analyzed for differences between focal and total cryotherapy and between very cold (<-76°C) and moderate-cold (≥-76°C) minimum tumor temperatures.A total of 197 patients responded to a total of 547 questionnaires. Focal and total cryotherapy patients had initially lower sexual function scores relative to AS (year 1 mean difference focal: -31.7, P <.001; total: -48.1, P <.001). Focal cryotherapy was associated with a more rapid improvement in sexual function. Both

2017 Urology

189. Outcome of spray cryotherapy plus functional endoscopic sinus surgery on management of healing in nasal polyposis. (Abstract)

Outcome of spray cryotherapy plus functional endoscopic sinus surgery on management of healing in nasal polyposis. Nasal Polyposis is a benign tumor in nasal or paranasal mucosa, which confronts difficulties in management of healing after treatments with surgery. The aim of this study was to evaluate the effects of Spray Cryotherapy (SCT) on management of healing in patients with nasal polyposis who undergone functional endoscopic sinus surgery.In this prospective, clinical trial study, we (...) investigated on 40 patients with nasal polyposis that had indication for functional endoscopic sinus surgery. Patients were divided randomly into two parallel group; cryotherapy (with SCT) and placebo (without SCT). Evaluation of healing after surgery was evaluated with Lund-Mackay and The Sino-nasal outcome test (SNOT-22)-22 scores.Postoperatively, Lund-Mackay and SNOT-22 scores were significantly decreased in both groups, however these scores were significantly lower in cryotherapy group in comparison

2017 American Journal of Otolaryngology Controlled trial quality: uncertain

190. Intracanal Cryotherapy Reduces Postoperative Pain in Teeth with Symptomatic Apical Periodontitis: A Randomized Multicenter Clinical Trial. Full Text available with Trip Pro

Intracanal Cryotherapy Reduces Postoperative Pain in Teeth with Symptomatic Apical Periodontitis: A Randomized Multicenter Clinical Trial. A prospective, multicentered, randomized clinical trial was designed to assess if controlled irrigation with cold saline could result in less incidence and intensity of postoperative pain in patients presenting with pulp necrosis and symptomatic apical periodontitis.A total of 210 patients (presenting with necrotic uniradicular teeth with a diagnosis (...) the 2 groups were assessed using the Mann-Whitney U test.Patients in the control group presented a significantly higher incidence of postoperative pain, intensity, and need for medication intake (P < .05).Cryotherapy reduced the incidence of postoperative pain and the need for medication intake in patients presenting with a diagnosis of necrotic pulp and symptomatic apical periodontitis.Copyright © 2017 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

2017 Journal of Endodontics Controlled trial quality: uncertain

191. Pre-emptive ice cube cryotherapy for reducing pain from local anaesthetic injections for simple lacerations: a randomised controlled trial. (Abstract)

Pre-emptive ice cube cryotherapy for reducing pain from local anaesthetic injections for simple lacerations: a randomised controlled trial. Subcutaneous local anaesthetic injection can be painful to patients in the ED. We evaluated the effect of cryotherapy by application of an ice cube to the injection site prior to injection in patients with simple lacerations.We conducted a prospective, randomised, controlled trial in consented patients with simple lacerations needing primary repair (...) at a single emergency centre from April to July 2016. We randomly assigned patients undergoing repair for simple lacerations to either the cryotherapy group or the control group (standard care; no cryotherapy or other pretreatment of the injection site). In cryotherapy group subjects, we applied an ice cube (size: 1.5×1.5×1.5 cm) placed inside a sterile glove on the wound at the anticipated subcutaneous lidocaine injection site for 2 min prior to injection. The primary outcome was a subjective numeric

2017 Emergency Medicine Journal Controlled trial quality: predicted high

192. Cryotherapy for Intra- and Perianal High-Grade Squamous Intraepithelial Lesions in HIV-Positive Men who have Sex with Men. Full Text available with Trip Pro

Cryotherapy for Intra- and Perianal High-Grade Squamous Intraepithelial Lesions in HIV-Positive Men who have Sex with Men. Available treatment options for anal high-grade squamous intraepithelial lesions (HSIL) in HIV-positive men who have sex with men (MSM) are limited by low response rates and frequent recurrences. Cryotherapy is an established therapeutic option for several pre-malignant skin disorders.This retrospective, non-randomized study included HIV-positive MSM who received intra (...) - and/or perianal HSIL cryotherapy treatment between 30 December 2008 and 23 April 2015. Cryotherapy was applied in sessions 4-6 weeks apart for a maximum of five sessions. Patients received a follow-up high-resolution anoscopy (HRA) to assess treatment response. Complete and partial treatment responders were followed-up after 6 months and then every 6-12 months to investigate recurrent HSILs.Of 64 patients [median age 48 years; interquartile range (IQR) 42-56] included in the study, six were lost to follow-up

2017 American journal of clinical dermatology

193. The Effect of Cryotherapy in Hailey-Hailey Disease Full Text available with Trip Pro

The Effect of Cryotherapy in Hailey-Hailey Disease 28223763 2018 11 13 1013-9087 29 1 2017 Feb Annals of dermatology Ann Dermatol The Effect of Cryotherapy in Hailey-Hailey Disease. 117-118 10.5021/ad.2017.29.1.117 Son Jee Hee JH Department of Dermatology, Hallym University College of Medicine, Seoul, Korea. Cho Yong Se YS Department of Dermatology, Hallym University College of Medicine, Seoul, Korea. Byun Yun Sun YS Department of Dermatology, Hallym University College of Medicine, Seoul, Korea

2017 Annals of dermatology

194. Cryotherapy in gastrointestinal endoscopy Full Text available with Trip Pro

Cryotherapy in gastrointestinal endoscopy 29905303 2018 11 14 2468-4481 2 5 2017 May VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy VideoGIE Cryotherapy in gastrointestinal endoscopy. 89-95 10.1016/j.vgie.2017.01.021 ASGE Technology Committee Parsi Mansour A MA Trindade Arvind J AJ Bhutani Manoop S MS Melson Joshua J Navaneethan Udayakumar U Thosani Nirav N Trikudanathan Guru G Watson Rabindra R RR Maple John T JT eng Journal Article 2017 02 06

2017 VideoGIE

195. CORR Insights®: Freezing Nitrogen Ethanol Composite May be a Viable Approach for Cryotherapy of Human Giant Cell Tumor of Bone Full Text available with Trip Pro

CORR Insights®: Freezing Nitrogen Ethanol Composite May be a Viable Approach for Cryotherapy of Human Giant Cell Tumor of Bone 28243975 2017 11 20 2018 12 02 1528-1132 475 6 2017 06 Clinical orthopaedics and related research Clin. Orthop. Relat. Res. CORR Insights ® : Freezing Nitrogen Ethanol Composite May be a Viable Approach for Cryotherapy of Human Giant Cell Tumor of Bone. 1664-1667 10.1007/s11999-017-5292-y Healey John H JH Orthopaedic Service, Department of Surgery, Memorial Sloan (...) Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. healeyj@mskcc.org. eng Journal Article Comment 2017 02 27 United States Clin Orthop Relat Res 0075674 0009-921X 3K9958V90M Ethanol N762921K75 Nitrogen AIM IM Clin Orthop Relat Res. 2017 Jun;475(6):1650-1663 28197783 Bone Neoplasms Cryotherapy Ethanol Freezing Giant Cell Tumor of Bone Humans Nitrogen 2017 01 26 2017 02 17 2017 3 1 6 0 2017 11 29 6 0 2017 3 1 6 0 ppublish 28243975 10.1007/s11999-017-5292-y 10.1007/s11999-017-5292-y

2017 Clinical Orthopaedics and Related Research

196. A Computerized Tutor Prototype for Prostate Cryotherapy: Key Building Blocks and System Evaluation Full Text available with Trip Pro

A Computerized Tutor Prototype for Prostate Cryotherapy: Key Building Blocks and System Evaluation This paper focuses on the evaluation of a prototype for a computer-based tutoring system for prostate cryosurgery, while reviewing its key building blocks and their benchmark performance. The tutoring system lists geometrical constraints of cryoprobe placement, displays a rendered shape of the prostate, simulates cryoprobe insertion, enables distance measurements, simulates the corresponding (...) outside of the operation room. System validation of the tutor has been performed by collecting training data from surgical residents, having no prior experience or advanced knowledge of cryotherapy. Furthermore, the system has been evaluated by graduate engineering students having no formal education in medicine. In terms of match between a planning isotherm and the target region shape, results demonstrate medical residents' performance improved from 4.4% in a pretest to 37.8% in a posttest over

2017 Proceedings of SPIE--the International Society for Optical Engineering

197. Current status of spray cryotherapy for airway disease Full Text available with Trip Pro

Current status of spray cryotherapy for airway disease The use of liquid nitrogen to treat skin and mucosal lesions is well understood in the dermatologic and gastrointestinal literature. Direct spray cryotherapy (SCT) in the airway has shown promising results in the treatment of esophageal premalignant and even invasive lesions. In the airway, several studies have shown it to be a safe, effective treatment for both benign and malignant disease. It is easily administered in the outpatient (...) setting and can be repeated several times without undue side effects. In this article, we review the current literature on the use of SCT for the treatment of endobronchial lesions and also describe our own institutional experience of the use of SCT in the airway. The use of proper technique and airway venting is important in mitigating the complications of barotrauma from massive expansion of nitrogen upon conversion from the liquid to gaseous state. We also review some of the basic science

2017 Journal of thoracic disease

198. Postoperative complications with cryotherapy in bone tumors Full Text available with Trip Pro

pouring liquid nitrogen into curettaged bone defects, and to review our current indications and surgical technique in bone tumor management. We reviewed charts in over 200 patients who received cryoablation for bone tumors from 1994 to 2015. Imaging studies were evaluated in all patients diagnosed with a complication. All patients receiving cryotherapy had soft tissue management intraoperatively that included warm saline directed to the structures. Liquid nitrogen was poured into the bone defect (...) Postoperative complications with cryotherapy in bone tumors The technique of cryosurgery has been used to control local recurrence in a variety of benign and malignant bone tumors. Early studies revealed significant complication rates (25%) that included fracture, infection, and soft tissue injury. Our method of cryosurgery has yielded excellent tumor control with improved complication rates. The objective of this study is to determine the characteristics of postoperative complications after

2017 Journal of bone oncology

199. Cryotherapy: Are we freezing the benefits of exercise? Full Text available with Trip Pro

Cryotherapy: Are we freezing the benefits of exercise? 28944266 2018 11 13 2332-8940 4 3 2017 Temperature (Austin, Tex.) Temperature (Austin) Cryotherapy: Are we freezing the benefits of exercise? 211-213 10.1080/23328940.2017.1304194 Peake Jonathan M JM Tissue Repair and Translational Physiology Research Group School of Biomedical Sciences and Institute of Health and Biomedical Innovation Queensland University of Technology, Brisbane, AustraliaCentre of Excellence for Applied Sport Science

2017 Temperature: Multidisciplinary Biomedical Journal

200. A Non–Gas-Based Cryotherapy System for the Treatment of Cervical Intraepithelial Neoplasia: A Mixed-Methods Approach for Initial Development and Testing Full Text available with Trip Pro

A Non–Gas-Based Cryotherapy System for the Treatment of Cervical Intraepithelial Neoplasia: A Mixed-Methods Approach for Initial Development and Testing Gas-based cryotherapy is the most widely used treatment strategy for cervical intraepithelial neoplasia (CIN) in low-resource settings, but reliance on gas presents challenges in low- and middle-income countries (LMICs). Our team adapted the original CryoPen Cryosurgical System, a cryotherapy device that does not require compressed gas (...) the adapted CryoPen and the standard cryotherapy device. In 80% of the cases in the pilot study, the adapted CryoPen achieved the target depth of necrosis 3.5 mm established in the pathology review.The LMIC-adapted CryoPen overcomes barriers to standard gas-based cryotherapy by eliminating dependency on gas, increasing portability, and ensuring consistent freeze temperatures. Further testing and evaluation of the adapted CryoPen will be pursued to assess scalability and potential impact of this device

2017 Global Health: Science and Practice

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