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161. Various modifications of a vascularized nasoseptal flap for repair of extensive skull base dural defects. (PubMed)

encountered no wound complication in this series, while crusting at the donor site required daily nasal toilette and frequent debridement until the completion of mucosalization, which usually takes 8 to 12 weeks after surgery.CONCLUSIONSExtended nasoseptal flaps are a reliable and versatile option that can be used to reconstruct extensive skull base dural defects resulting from destruction by large invasive tumors or complex endoscopic endonasal surgery. An extended nasoseptal flap that includes

2019 Journal of Neurosurgery

163. Editorial Commentary: Release of the Medial Collateral During Arthroscopic Meniscectomy Should Be Encouraged, Not Feared! (PubMed)

Editorial Commentary: Release of the Medial Collateral During Arthroscopic Meniscectomy Should Be Encouraged, Not Feared! In patients having arthroscopic medial meniscectomy, percutaneous pie crust or intra-articular release of the proximal medial collateral ligament is preferable to iatrogenic damage to the cartilage of the medial femoral condyle. In patients with tight medial compartments, release is recommended. Release of the medial collateral ligament during arthroscopic partial medial

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2019 Arthroscopy

164. Pearls and pitfalls of bathing in atopic dermatitis. (PubMed)

Pearls and pitfalls of bathing in atopic dermatitis. The latest guidelines of the American Academy of Dermatology suggest bathing as an advantageous nonpharmacologic intervention for regular skin care of patients with atopic dermatitis. Regular bathing with water can hydrate the skin, remove scale, crust, irritants, and allergens, enhance penetration of topical agents, and potentially reduce bacterial colonization. However, it is still unclear whether the addition of oils, emollients, and other

2019 Allergy and Asthma Proceedings

165. Novel technique for nasal septal button insertion: the sutured rosette. (PubMed)

Novel technique for nasal septal button insertion: the sutured rosette. 1.Septal button placement can be challenging. 2.The sutured rosette technique involves folding one flange into a rosette shape, securing it with suture and cutting the suture to release the rosette into a full flange once in proper positioning. 3.The sutured rosette technique is a novel approach to easily placing a septal button while improving crusting and nasal congestion. This article is protected by copyright. All

2019 Clinical Otolaryngology

166. Outcomes of Nasal Septal Perforation Repair Using Combined Temporoparietal Fascia Graft and Polydioxanone Plate Construct. (PubMed)

Symptom Evaluation (NOSE) scores were assessed.A total of 17 patients (12 women and 5 men; mean [SD] age, 45 [15] years) were included. The causes of perforations were iatrogenic (9 [53%]), rheumatologic (2 [12%]), and unknown or idiopathic (6 [35%]). Patients most commonly presented with nasal crusting (12 [71%]), whistling (9 [53%]), nasal obstruction (9 [53%]), and epistaxis (5 [29%]). Mean (SD) perforation size was 0.99 (1.04) cm2. Mean (SD) postoperative follow-up was 6.1 (4.1) months. A total

2019 JAMA facial plastic surgery

168. Shingles

, and fever. Rash — usually unilateral. Macules and papules develop into vesicular lesions in a dermatomal distribution which burst and form ulcers and crusts. Note that the rash may be atypical in certain groups of people, for example older or immunocompromised people. Pain — intense neuralgic pain over the affected area, especially in people with trigeminal nerve involvement. Healing (2–4 weeks) — the lesions usually crust over within 7–10 days. A person with shingles should be offered self-care advice (...) ) in the affected skin. The prodrome may also include headache, malaise, and occasionally fever. Rash — usually unilateral. Macules and papules develop into vesicular lesions in a dermatomal distribution. The location depends on which nerve is involved, but shingles usually occurs on the thorax, with dermatomes T1 to L2 most commonly affected. The vesicles then burst, releasing varicella-zoster virus, and form ulcers and crusts. Note that the rash may be atypical in certain groups of people, for example older

2017 NICE Clinical Knowledge Summaries

169. Breastfeeding problems

exudate or crust may suggest associated bacterial infection. Mastitis and breast abscess The woman often has a fever and is systemically unwell. Mastitis may present with a hard painful swelling in a wedge-shaped distribution in one breast, with erythema of the overlying skin. A breast abscess may present with a worsening painful breast lump, which may be fluctuant, and the overlying skin is often erythematous and warm. There may be a persistent fever and systemic symptoms. See the CKS topic (...) of the nipple, and fissuring across the top of the nipple or around the base. There may be flattening of the nipple from side to side, with a pressure line across the tip. Blocked duct There may be a small white spot (bleb) about 1 mm in diameter at the end of the nipple. There may be a localized, tender cord of tissue in one breast, which may be relieved by expression of milk; the overlying skin may be erythematous. Nipple infection Bacterial infection may present with purulent nipple discharge, crusting

2017 NICE Clinical Knowledge Summaries

170. Occurrence and identification of contagious ecthyma in blackbuck (PubMed)

Occurrence and identification of contagious ecthyma in blackbuck A carcass of male free ranging adult blackbuck (Antilope cervicapra) was presented for necropsy examination exhibiting thick confluent nodular skin lesions around the mouth and the dry scaly crusts/fissures on the skin of abdomen, thigh and shoulder with subcutaneous haemorrhages. The skin sample around mouth was found positive for orf virus (ORFV) identified by counterimmunoelectrophoresis and PCR. Histopathology of the mouth

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2016 Virusdisease

171. A quick update on the migration to a new domain

selective pressure and how to take up some yeast from the top of my fermenters without spoiling the beer but that's a work in progress with due date around end of January 2018 when I'll fabricate the kit and fermenters. What I meant to say is that, I will test with yeast based pizza crust but if it's not a success, dry yeast will be fine. They both come from the same family. Alain to post comments By Alain (not verified) on 27 Oct 2017 to post comments By Jane Ostentatious (not verified) on 27 Oct 2017

2017 Respectful Insolence

172. Neville Goodman’s metaphor watch: Tectonic shifts

in the mantle, cause earthquakes and volcanoes. The idea of these mobile tectonic plates developed during the 1960s, although the term tectonics had already entered geology, referring simply to the structure of the Earth’s crust or changes affecting it. Paradoxically, a tectonic shift occurs very slowly, but the subsequent events can be catastrophically sudden. The geological term has been borrowed by medicine in ophthalmology: it is a form of corneal surgery. And also , as very many terms have been

2017 The BMJ Blog

173. Jeffrey Aronson: When I use a word . . . Artificiality

in women than in men; they are usually in their teens or 20s and consistently deny that the rash is self-induced. The lesions, which can take any form (erythema, swelling, blisters, denuded areas, crusts, cuts, burns, and scars), are generally of a bizarre shape, with irregular outlines, well demarcated from the surrounding normal skin. When I searched PubMed for “artificial”, even restricting occurrences to the titles of papers, I got nearly 40 000 hits. It appears that there is little that cannot

2017 The BMJ Blog

175. Basal cell carcinoma (BCC) (periocular)

or crusting Change in lid contour/redirection or loss of eyelashes Loss of texture of surrounding skin Later cases sometimes pigmented (more prominent in dark skinned races) Differential diagnosis Squamous cell carcinoma, chalazion, keratoacanthoma, actinic keratosis, molluscum contagiosum, papilloma Anterior marginal blepharitis can resemble sclerosing BCC BCC diagnosis is suspected clinically but is usually confirmed by histology which can also help to define the clinical subtype Management

2015 College of Optometrists

176. Professor Christopher Exley: The latest darling of the antivaccine movement

was “inflicted” on us over 4 billion years ago when it became the third most common element in the Earth’s crust. That “peck of dirt” is scarcely all silica; a lot of it is clay: various hydrated silicates of–you guessed it– aluminum (Shock! Gasp!) That doesn’t even count all the aluminum in the dust you breathe in with every lungful of air or the clay minerals that go (as the antivaxers love to say) “straight into your bloodstream” every time you skin your knee. (Of course, vaccines don’t “go straight (...) a Biologist (University of Stirling) with a PhD in the ecotoxicology of aluminium (University of Stirling). My research career ( 1984-present ) has focussed upon an intriguing paradox; ‘how come the third most abundant element of the Earth’s crust (aluminium) is non-essential and largely inimcal [ sic ] to life’. Investigating this mystery has required research in myriad fields from the basic inorganic chemistry of the reaction of aluminium and silicon to the potentially complex biological availability

2017 Respectful Insolence

177. Brodalumab (Kyntheum) - plaque psoriasis

107059 Monkey 5/sex/group including 2/sex/group recovery SC: 0, 25, 90, 350 IV: 350 4 weeks + 13 weeks recovery 350 • no brodalumab-related adverse effects • at 350 mg/kg, small areas of broken, crusted skin; these areas were partly associated with ulcers or inflammation; findings were reversible 107713 Monkey 6/sex/group including 2/sex/group recovery SC: 0, 25, 90, 350 3 months + 17 weeks recovery 90 • at 350 mg/kg, brodalumab-related adverse effects at injection sites: - increased incidence (...) of discoloration, thickening, and/or crusting; - slight to marked, subacute to chronic histiocytic inflammation - abscess at injection site in 1 F • at 90 mg/kg: macroscopic and microscopic injection site findings less-severe, non-adverse • evidence for reversibility of inflammation at injection sites Assessment report EMA/381484/2017 Page 21/135 Study ID Species/Sex/ Number/Group Dose/Route mg/kg/week Duration NOAEL (mg/kg) Major findings 107714 Monkey 4/sex/group + 2/sex/group recovery control + high dose

2017 European Medicines Agency - EPARs

178. Organic compounds in fluid inclusions of Archean quartz-Analogues of prebiotic chemistry on early Earth. (PubMed)

Organic compounds in fluid inclusions of Archean quartz-Analogues of prebiotic chemistry on early Earth. The origin of life is still an unsolved mystery in science. Hypothetically, prebiotic chemistry and the formation of protocells may have evolved in the hydrothermal environment of tectonic fault zones in the upper continental crust, an environment where sensitive molecules are protected against degradation induced e.g. by UV radiation. The composition of fluid inclusions in minerals (...) have been formed by hydrothermal processes. Stable-isotope analysis confirms that the methane found in the inclusions has most likely been formed from abiotic sources by hydrothermal chemistry. Obviously, the liquid phase in the continental Archean crust provided an interesting choice of functional organic molecules. We conclude that organic substances such as these could have made an important contribution to prebiotic chemistry which might eventually have led to the formation of living cells.

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2017 PLoS ONE

179. Average Distance to the Nearest Forest is Increasing with Forest Loss in the US

, which gives the initial forest state. Example B and D show “aggregated attrition” or the loss of complete intact sections—say, you have a large pizza and someone grabbed a giant slice out of it. Examples C and E show equal decreases in area as B and D, but are more random—the term used here is “dispersed attrition.” Think more like one of those thin crust pizzas where you can grab pieces out of the middle. Figure One, from Yang and Mountrakis (2017). Case (a) shows the initial forest state followed (...) importance in land use and land cover change studies. And if you want to stick with that ill-advised pizza metaphor, imagine someone who only eats crusts or just takes bites out of random pieces and puts them back. Hopefully no one eats pizza like that, though. Ugh. Yang and Mountrakis delve into the connection between forest cover and forest attrition. They find a non-linear relationship where initially, as forest cover decreases, forest attrition increases slowly. As forest cover decreases past

2017 PLOS Blogs Network

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