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141. Skin Cancer Treatment (PDQ®): Patient Version

and raised (right panel). Squamous cell carcinoma occurs on areas of the skin that have been damaged by the sun, such as the ears, lower lip, and the back of the hands. Squamous cell carcinoma may also appear on areas of the skin that have been sunburned or exposed to or . Often this looks like a firm red bump. The may feel scaly, bleed, or form a crust. Squamous cell tumors may spread to nearby . Squamous cell carcinoma that has not spread can usually be . Actinic keratosis is a skin

2018 PDQ - NCI's Comprehensive Cancer Database

142. Langerhans Cell Histiocytosis Treatment (PDQ®): Patient Version

: Flaking of the scalp that may look like dandruff. Raised, red or brown, crusted rash in the area, , back, or chest, that may be itchy or painful. Bumps or on the scalp. Ulcers behind the ears, under the , or in the groin area. Fingernails that fall off or have discolored grooves that run the across the nail. Mouth Signs or symptoms of LCH that affects the mouth may include: Swollen . Sores on the roof of the mouth, inside the cheeks, or on the tongue or lips. Teeth that become uneven or fall out. Bone

2018 PDQ - NCI's Comprehensive Cancer Database

144. Public health guidance on varicella vaccination in the European Union

to vesicular lesions before crusting. Successive crops (usually two to four) appear over several days. The rash tends to have central distribution, with the highest concentration of lesions on the trunk [31]. Lesions can also occur on mucous membranes and cornea [5]. Humans are the only VZV reservoir which can be transmitted person-to-person by direct contact with respiratory secretions or inhalation of vesicle fluid (airborne spread) [31]. The period of communicability goes from one to two days before (...) the onset of the rash to when the lesions are crusted over, usually four to five days after the appearance of the rash. The incubation period goes from 10 to 21 days, commonly 14 to 16 days [31]. Although most people with varicella make full recoveries, complications can occur, especially in older age groups, pregnant women (including congenital varicella syndrome and neonatal varicella) and immunocompromised patients. Varicella is responsible for a substantial burden of hospitalisations

2015 European Centre for Disease Prevention and Control - Public Health Guidance

145. Sofosbuvir induced steven Johnson Syndrome in a patient with hepatitis C virus‐related cirrhosis (PubMed)

weeks of therapy with peginterferon alpha-2a and oral ribavirin. After peginterferon withdrawal and stabilization, oral sofosbuvir and ribavirin were started; 10 days later, he developed itching over the trunk and legs, followed by multiple papules and vesicles over an erythematous base. Over the next 15 days, the rash progressed with the formation of blisters and peeling skin. Simultaneously, the oral mucosa and lips developed crusting and painful erosions. Considering drug-induced Steven John

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2017 Hepatology communications

146. Breastfeeding Healthy Term Infants

• Mothers with active herpes simplex lesions on or near the nipple should interrupt breastfeeding on the breast and nipple affected until lesions are crusted or resolved 2,26,45 • Mothers receiving a high-dose of the antibiotic Metroridazole: discontinue breastfeeding for 12 – 24 hours to allow excretion of the dose 45 • Mothers with active tuberculosis who are not receiving adequate therapy are considered infectious. 2 Following 2-weeks of appropriate TB drug therapy breastfeeding is recommended

2015 British Columbia Perinatal Health Program

147. Does lowering a fever >101F in children improve clinical outcomes?

? View/ Open Date 2010-06 Format Metadata Abstract Treating fever significantly increases comfort, activity, feeding, and fluid intake and decreases the patient's temperature compared with placebo (strength of recommendation (SOR): A, multiple randomized controlled trials [RCTs]). It doesn't shorten or prolong the overall duration of illness or reduce the recurrence of febrile seizures (SOR: A, multiple RCTs). In patients with varicella, reducing fever prolongs the time it takes for lesions to crust

2015 Clinical Inquiries

148. Chickenpox in Pregnancy

a chickenpox rash should immediately contact their general practitioner. Women should avoid contact with potentially susceptible individuals, e.g. other pregnant women and neonates, until the lesions have crusted over. This is usually about 5 days after the onset of the rash. Symptomatic treatment and hygiene is advised to prevent secondary bacterial infection of the lesions. Oral aciclovir should be prescribed for pregnant women with chickenpox if they present within 24 hours of the onset of the rash (...) , clothing and bedding). The primary infection is characterised by fever, malaise and a pruritic rash that develops into crops of maculopapules, which become vesicular and crust over before healing. The incubation C C P P P P P DRCOG Green-top Guideline No. 13 © Royal College of Obstetricians and Gynaecologists 5 of 17 period is between 1 and 3 weeks and the disease is infectious 48 hours before the rash appears and continues to be infectious until the vesicles crust over. The vesicles usually crust over

2015 Royal College of Obstetricians and Gynaecologists

149. Scabies

: Crusted scabies; Indigenous communities; Infestations; Norwegian scabies; Poverty; Pruritus

2015 Canadian Paediatric Society

150. Peritoneal dialysis catheter-related infection: exit site and tunnel

SAY? Kidney Disease Outcomes Quality Initiative: No recommendation. UK Renal Association: 2010. [17] Topical antibiotic administration should be used to reduce the frequency of S. aureus and Gram negative exit-site infection and peritonitis (1A). Exit site infection is suggested by pain, swelling, crusting, erythema and serous discharge; purulent discharge always indicates infection. Swabs should be taken for culture and initial empiric therapy should be with oral antibiotics that will cover S

2014 KHA-CARI Guidelines

151. Corticosteroid-eluting bioabsorbable stent or spacer insertion during endoscopic sinus surgery to treat chronic rhinosinusitis

4 of 75 5 Safety Safety This section describes safety outcomes from the published literature that the Committee considered as part of the evidence about this procedure. For more detailed information on the evidence, see the interventional procedure overview. 5.1 Crusting, granulation and scarring of the middle turbinate 1 week after the procedure was reported in 1 patient in a randomised controlled trial (RCT) of 105 patients treated by a corticosteroid-releasing bioabsorbable stent in 1 side (...) , but was considered to be exacerbated by presence of crusting sticking to the stent. The condition resolved without sequelae after stent removal. 5.3 Infection at 2-week follow-up was reported in 1 patient in the RCT of 105 patients treated by a corticosteroid-releasing bioabsorbable stent in 1 side and a non-corticosteroid-releasing bioabsorbable stent in the other. The patient was treated with a prednisone taper and antibiotics. The infection resolved without sequelae. 5.4 Peri-orbital cellulitis was reported

2016 National Institute for Health and Clinical Excellence - Interventional Procedures

152. Does lowering a fever >101F in children improve clinical outcomes?

? View/ Open Date 2010-06 Format Metadata Abstract Treating fever significantly increases comfort, activity, feeding, and fluid intake and decreases the patient's temperature compared with placebo (strength of recommendation (SOR): A, multiple randomized controlled trials [RCTs]). It doesn't shorten or prolong the overall duration of illness or reduce the recurrence of febrile seizures (SOR: A, multiple RCTs). In patients with varicella, reducing fever prolongs the time it takes for lesions to crust

2014 Clinical Inquiries

153. Meals, a powerful influence on healthcare professionals too

are “the price to be paid” for wooing healthcare professionals and building a pleasant even “friendly” relationship with them. Acceptance of a small gift or dinner invitation creates a bond between the giver and the recipient who feels gratitude and a sense of obligation. Throughout the world, healthcare professionals swear in good faith that the pharmaceutical companies “cannot bribe them with a pen or a crust of bread”. However the compulsion to reciprocate is independent of the value of the gift. It can

2014 Prescrire

154. Epidemiologic and Ecologic Investigations of Monkeypox, Likouala Department, Republic of the Congo, 2017. (PubMed)

Epidemiologic and Ecologic Investigations of Monkeypox, Likouala Department, Republic of the Congo, 2017. Monkeypox, caused by a zoonotic orthopoxvirus, is endemic in Central and West Africa. Monkeypox has been sporadically reported in the Republic of the Congo. During March 22-April 5, 2017, we investigated 43 suspected human monkeypox cases. We interviewed suspected case-patients and collected dried blood strips and vesicular and crust specimens (active lesions), which we tested

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2019 Emerging Infectious Diseases

155. A computational fluid dynamics analysis of the effects of size and shape of anterior nasal septal perforations. (PubMed)

A computational fluid dynamics analysis of the effects of size and shape of anterior nasal septal perforations. Nasal septal perforations (NSPs) often cause bleeding, crusting, obstruction, and/or whistling. The objective was to analyze the impact of anterior NSP size and shape on nasal physiology using computational fluid dynamics (CFD).A 3-dimensional model of the nasal cavity was constructed from a radiologically normal CT scan using imaging software. Anterior NSPs (ovoid (ONSP): 0.5, 1, 2 (...) and water vapor flux were highest posteriorly and lowest anteriorly, generally increasing with size in those regions. RNSPs had greater heat and water vapor flux compared to corresponding size ONSPs. Resistance decreased by 10% or more from normal only in the 3 cm ONSP. Maximum water content was achieved more posteriorly in larger NSP nasal cavities.High wall shear and heat and water vapor flux in posterior perforation regions may explain the crusting most commonly noted on posterior NSP edges

2019 Rhinology

156. Comparing biosignatures in aged basalt glass from North Pond, Mid-Atlantic Ridge and the Louisville Seamount Trail, off New Zealand. (PubMed)

is known about the relationship between the physical and chemical nature of the habitat and the prevalent types of biosignatures. Here, we report and compare strongly variable biosignatures from two different oceanic study sites. We analyzed rock samples for their textural biosignatures and associated organic molecules. The biosignatures from the 8 Ma North Pond Region, which represents young, well-oxygenated, and hydrologically active crust, are characterized by little textural diversity. The organic (...) propose that diverse biosignatures in oceanic crust may form during different stages of crustal evolution.

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2018 PLoS ONE

157. Kate Harding: Life after a loss— “Onwards . . . There is no other way”

the obligatory trip to the GMC’s gleaming and soulless offices in Manchester, where I arrived one morning in mid-January to have my identity confirmed, in order to get back to earning a crust. Because of the GMC’s association with Richard’s depression and subsequent death, this was an emotional journey (his decline was certainly multifactorial, and I would never go so far as to paint him as a “victim of the GMC;” but the letter of notification stating that he’d had a complaint made against him some 18 months

2018 The BMJ Blog

158. Topical Mitomycin-C can help as an adjunct to alkaline nasal wash and rifampicin in primary atrophic rhinitis. (PubMed)

hospital in January 2016 and March 2018. Fifty adult patients aged 18 to 45 with PAR were randomly divided into 2 groups.treatment with Mitomycin-C dissolved in an alkaline wash plus rifampicin and control group: only treated with rifampicin and alkaline nasal wash. Subjective scores for the following symptoms: After 12 weeks of treatment, foul smell, anosmia, crusting, epistaxis, and nasal blockade, an objective score of crusting, the status of nasal mucosa, nature of the secretions and condition

2019 American Journal of Otolaryngology

159. Treatment of telangiectasia on the cheeks with a compact yellow (585 nm) semiconductor laser and a green (532 nm) KTP laser: a randomized double-blinded split-face trial. (PubMed)

). The amount of pain was higher with PhotoLase compared to KTP (67.7 vs. 34.6, P < 0.001). There was no difference in the frequency of erythema, crusting or purpura between the devices, but more blistering and less edema were seen after PhotoLase treatment (P < 0.05). Treatment with PhotoLase was evaluated to be 4.7-fold faster than with KTP and the PhotoLase system was more compact, narrower, lighter, and easier to carry than KTP.The investigational PhotoLase laser enables significantly faster treatments

2019 Lasers in surgery and medicine

160. MKSAP: 32-year-old man with an intermittent pruritic rash

to conditions in which there is evidence of extensive bacterial infection. Clinical signs of bacterial infection typically include weeping of serous fluid, pustules, honey-colored crusting, unexplained worsening of dermatitis, or failure to respond to correct therapy. There is no indication for treatment with systemic antibiotics in this patient. Oral prednisone should be considered only in severe, acute exacerbations of atopic dermatitis and not for regular management. Chronic oral glucocorticoid treatment

2019 KevinMD blog

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