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Cranial Nerve 10

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161. Treatment Design and Rationale for a Randomized Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for SCLC: PREMER Trial on Behalf of the Oncologic Group for the Study of Lung Cancer/Spanish Radiation Oncology Group-Radiation (Abstract)

Treatment Design and Rationale for a Randomized Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for SCLC: PREMER Trial on Behalf of the Oncologic Group for the Study of Lung Cancer/Spanish Radiation Oncology Group-Radiation Prophylactic cranial irradiation (PCI) is part of the usual treatment in most patients with small-cell lung cancer (SCLC) and response after treatment of the primary tumor. Clinical evidence suggests that radiation dose received (...) %) and a significance level of 5% (α = 5%), with a maximum loss to follow-up of 10%.This study is an important step in introducing a new therapeutic approach to patients with SCLC candidates for PCI.Copyright © 2018 Elsevier Inc. All rights reserved.

2018 Clinical lung cancer Controlled trial quality: uncertain

162. The effect of cranial electrotherapy stimulation on sleep in healthy women. (Abstract)

The effect of cranial electrotherapy stimulation on sleep in healthy women. Cranial electrotherapy stimulation (CES) is considered to be a potential treatment for insomnia. Women are more likely to suffer from insomnia than men. Therefore we studied the effect of CES on sleep efficiency in young healthy women.A randomized, controlled clinical study was conducted on 40 women (age 18-35 years) without sleep disorders. Each subject underwent two nights of polysomnography in a sleep center. During (...) (sham). Using EEG spectral analysis there was evidence of a frequency-lowering influence on the low-α frequency band (8-10 Hz).At most we may assume a reproducible effect on the α frequency measured in the EEG for application of CES with current levels  >100 µA and presumably also with frequencies  >0.5 Hz, with application directly at the cranium. We found no influence on sleep parameters. The effect on the low-α band evidenced in quantitative EEG analysis would require further investigation

2018 Physiological measurement Controlled trial quality: uncertain

163. Cardiac autonomic response after cranial technique of the fourth ventricle (cv4) compression in systemic hypertensive subjects. (Abstract)

Cardiac autonomic response after cranial technique of the fourth ventricle (cv4) compression in systemic hypertensive subjects. The aim of this study was to compare blood pressure (BP) behavior and heart rate variability (HRV) among hypertensive stage I and normotensive individuals who were submitted to the cranial technique of the 4th ventricle compression (CV4), an osteopathic technique.In this experimental controlled study, thirty men between 40 and 60 years old were evaluated and divided (...) into two groups: normotensive (NT) and hypertensive (HT). The CV4 maneuver was applied in both groups and BP was measured at 5 (five) different stages: pre and post-intervention, 5, 10 and 15min after technique. Time-frequency parameters were obtained from measurements of RR intervals. Data were analyzed using an ANOVA two-way for analysis of the condition factor (NT and HT) and times with p-value ≤ .05.There was a reduction in the BP of the HT group. A significant intergroup difference (p = .01

2018 Journal of bodywork and movement therapies

164. Varicella zoster presenting as cranial polyneuropathy. (Abstract)

Varicella zoster presenting as cranial polyneuropathy. Cranial polyneuropathy is commonly caused by Lyme disease. We discuss the case of a man who presented with cranial nerve deficits causing dysphagia, dysphonia and facial weakness. This diagnostic dilemma stemmed from a workup that ruled out Lyme and vascular causes leading to an expanded search for infectious explanations, which revealed varicella zoster in the cerebrospinal fluid. On review, this phenomenon is rarely reported, but has been (...) observed with a number of herpes family viruses. In emergency department settings, clinical suspicion should be raised for VZV infection even in the absence of rash in patients that present with multiple cranial nerve palsies.Copyright © 2018. Published by Elsevier Inc.

2018 American Journal of Emergency Medicine

165. Symptom Burden Associated With Late Lower Cranial Neuropathy in Long-term Oropharyngeal Cancer Survivors. Full Text available with Trip Pro

Symptom Burden Associated With Late Lower Cranial Neuropathy in Long-term Oropharyngeal Cancer Survivors. Lower cranial neuropathy (LCNP) is a rare but potentially disabling result of radiotherapy and other head and neck cancer therapies. Survivors who develop late LCNP may experience profound functional impairment, with deficits in swallowing, speech, and voice.To investigate the association of late LCNP with severity of cancer treatment-related symptoms and subsequent general functional (...) impairment among oropharyngeal cancer (OPC) survivors.This cross-sectional survey study analyzed 889 OPC survivors nested within a retrospective cohort of OPC survivors treated at MD Anderson Cancer Center from January 1, 2000, to December 31, 2013. Eligible survey participants were disease free and completed OPC treatment 1 year or more before the survey. Data analysis was performed from October 10, 2017, to March 15, 2018.Late LCNP defined by onset 3 months or more after cancer therapy.The primary

2018 JAMA otolaryngology-- head & neck surgery

166. Use of collagen/chitosan sponges mineralized with hydroxyapatite for the repair of cranial defects in rats. (Abstract)

Use of collagen/chitosan sponges mineralized with hydroxyapatite for the repair of cranial defects in rats. In traumatology, we encounter several clinical challenges that involve extensive bone loss primarily related to trauma, conditions that can be treated with autologous grafts. A good alternative is the use of synthetic biomaterials as substitutes. These polymers provide a suitable environment for the growth of new bone and vascular tissue, which are essential for repair. Collagen (...) animals were used for the creation of a defect in the left parietal bone and were divided into three groups of 10 animals each: a control group without biomaterial implantation, a group receiving the blend of collagen and chitosan, and a group receiving this blend combined with hydroxyapatite. Each group was subdivided and the animals were sacrificed 3 or 8 weeks after surgery. After sacrifice, the skulls were removed for macroscopic photodocumentation and radiographic examination. The samples were

2018 Injury

167. Prophylactic cranial irradiation for limited-stage small-cell lung cancer patients: secondary findings from the prospective randomized phase 3 CONVERT trial. Full Text available with Trip Pro

Prophylactic cranial irradiation for limited-stage small-cell lung cancer patients: secondary findings from the prospective randomized phase 3 CONVERT trial. The impact of the dose and fractionation of thoracic radiotherapy on the risk of developing brain metastasis (BM) has not been evaluated prospectively in limited stage SCLC patients receiving prophylactic cerebral irradiation (PCI).Data from patients treated with PCI from the CONVERT trial were analyzed.Four hundred forty-nine of 547 (...) , weight loss of more than 10%, and tGTV were prognostic factors associated with OS. In the multivariate analysis, only tGTV was associated with OS. Delay between end of chemotherapy and PCI was not associated with OS.Patients receiving OD or BD thoracic radiotherapy have the same risk of developing BM. Larger tumors are associated with a higher risk of BM.Copyright © 2018 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

2018 Journal of Thoracic Oncology Controlled trial quality: uncertain

168. Lyme disease presenting with multiple cranial neuropathies on MRI Full Text available with Trip Pro

Lyme disease presenting with multiple cranial neuropathies on MRI We present the case of a 10-year old patient from southeastern Ontario with severe bilateral facial palsy. MRI was performed that showed extensive symmetric enhancement of cervical cranial nerve roots and multiple cranial nerves (III, V, VI, VII, VIII, X and XII). Lumbar puncture was performed that revealed pleocytosis and elevated proteins in the cerebrospinal fluid. Serology confirmed the diagnosis of neuroborreliosis

2018 IDCases

169. Predictive Value of Cranial Ultrasound for Neurodevelopmental Outcomes of Very Preterm Infants with Brain Injury Full Text available with Trip Pro

Predictive Value of Cranial Ultrasound for Neurodevelopmental Outcomes of Very Preterm Infants with Brain Injury Compared with full-term infants, very preterm infants are more vulnerable to injury and long-term disability and are at high risk of death. The predictive value of ultrasound and imaging on the neurodevelopment is one of the hot topics. This study aimed to investigate the relationship between cranial ultrasound (cUS) variables and neurodevelopmental outcomes of very preterm (...) rates and poorly developed brain nerves. Cerebral palsy can result from severe cerebral hemorrhage, moderate and severe hydrocephaly, and extensive c-PVL. The sustained, inhomogeneous echogenicity of white matter may suggest subtle brain injury.

2018 Chinese medical journal

170. Point-of-care Cranial Ultrasound in a Hemicraniectomy Patient Full Text available with Trip Pro

Point-of-care Cranial Ultrasound in a Hemicraniectomy Patient 30443636 2018 12 07 2474-252X 2 4 2018 Nov Clinical practice and cases in emergency medicine Clin Pract Cases Emerg Med Point-of-care Cranial Ultrasound in a Hemicraniectomy Patient. 375-377 10.5811/cpcem.2018.7.39379 Sarwal Aarti A Wake Forest School of Medicine, Department of Neurology, Winston-Salem, North Carolina. Elder Natalie M NM Wake Forest School of Medicine, Department of Emergency Medicine, Winston-Salem, North Carolina (...) . eng Journal Article 2018 09 10 United States Clin Pract Cases Emerg Med 101718968 2474-252X Conflicts of Interest: By the CPC-EM article submission agreement, all authors are required to disclose all affiliations, funding sources and financial or management relationships that could be perceived as potential sources of bias. The authors disclosed none. 2018 06 13 2018 06 19 2018 07 19 2018 11 17 6 0 2018 11 18 6 0 2018 11 18 6 1 epublish 30443636 10.5811/cpcem.2018.7.39379 cpcem-02-375 PMC6230339

2018 Clinical Practice and Cases in Emergency Medicine

171. Prophylactic cranial irradiation in small-cell lung cancer: update on patient selection, efficacy and outcomes Full Text available with Trip Pro

Prophylactic cranial irradiation in small-cell lung cancer: update on patient selection, efficacy and outcomes Over 10% of small-cell lung cancer (SCLC) patients have brain metastases (BM) at initial diagnosis; more than 50% will develop BM within 2 years. BM are detected in up to 80% of all patients at autopsy. After primary treatment, prophylactic cranial irradiation (PCI) has been established as standard of care in SCLC patients responding to initial therapy. Based on level I evidence, PCI

2018 Lung Cancer: Targets and Therapy

172. A hybrid volumetric dose verification method for single‐isocenter multiple‐target cranial SRS Full Text available with Trip Pro

A hybrid volumetric dose verification method for single‐isocenter multiple‐target cranial SRS A commercial semi-empirical volumetric dose verification system (PerFraction [PF], Sun Nuclear Corp.) extracts multi-leaf collimator positions from the electronic portal imaging device movies collected during a pre-treatment run, while the rest of the delivered control point information is harvested from the accelerator log files. This combination is used to reconstruct dose on a patient CT dataset (...) with a fast superposition/convolution algorithm. The method was validated for single-isocenter multi-target SRS VMAT treatments against absolute radiochromic film measurements in a cylindrical phantom. The targets ranged in size from 0.8 to 3.6 cm and in number from 3 to 10 per plan. A total of 17 films rotated at different angles around the cylinder axis were analyzed. Each of 27 total targets was intercepted by at least one film, and 2-4 different films were analyzed per plan. Film dose was always

2018 Journal of Applied Clinical Medical Physics

173. A novel tibial tuberosity advancement technique with cranial implant fixation (TTA CF): a pilot study in sheep Full Text available with Trip Pro

of osteotomy gap.Tibial tuberosity advancement with cranial implant fixation was performed in four sheep. Complete radiographic and clinical follow up was recorded. All four sheep had a complete osteotomy line healing at a mean of 10 weeks postoperative (range 8-12 weeks). None of the animals had osteotomy gap healing grades of poor. Minor complication included the minimally cracked Maquet hole on the postoperative radiographs, without displacement of the tibial crest which occurred in 2 sheep. Major (...) A novel tibial tuberosity advancement technique with cranial implant fixation (TTA CF): a pilot study in sheep Cranial cruciate ligament rupture is the most frequent orthopedic disorder in human and animals. An array of surgical techniques have been described to stabilize the stifle joint in dogs, including intraarticular stabilization, extraarticular stabilization, and tibial osteotomy techniques. Tibial plateau leveling osteotomy and tibial tuberosity advancement with a lot of modifications

2018 BMC veterinary research

174. SOCIETY FOR ENDOCRINOLOGY CLINICAL GUIDANCE: Inpatient management of cranial diabetes insipidus Full Text available with Trip Pro

SOCIETY FOR ENDOCRINOLOGY CLINICAL GUIDANCE: Inpatient management of cranial diabetes insipidus Cranial diabetes insipidus (CDI) is a treatable chronic condition that can potentially develop into a life-threatening medical emergency. CDI is due to the relative or absolute lack of the posterior pituitary hormone vasopressin (AVP), also known as anti-diuretic hormone. AVP deficiency results in uncontrolled diuresis. Complete deficiency can lead to polyuria exceeding 10 L/24 h. Given a functioning

2018 Endocrine connections

175. Comparison of three imaging modalities used to evaluate bone healing after tibial tuberosity advancement in cranial cruciate ligament-deficient dogs and comparison of the effect of a gelatinous matrix and a demineralized bone matrix mix on bone healing †Full Text available with Trip Pro

in cruciate deficient stifle joints by advancing the tuberosity while creating an osteotomy gap. The current study aims to: 1) compare three different imaging modalities to assess bone healing: ultrasound, radiographs and computed tomography (CT) and, to 2) compare the effect of a gelatinous matrix (GM) versus a demineralized bone matrix mix (DBM mix) on bone healing and bridging of this osteotomy gap in 10 otherwise healthy client-owned dogs with cranial cruciate ligament insufficiency. Osseous union (...) Comparison of three imaging modalities used to evaluate bone healing after tibial tuberosity advancement in cranial cruciate ligament-deficient dogs and comparison of the effect of a gelatinous matrix and a demineralized bone matrix mix on bone healing †Bone healing and assessment of the state of bone bridging is an important part of clinical orthopedics, whether for fracture healing or for follow up of osteotomy procedures. Tibial tuberosity advancement (TTA) is designed to restore stability

2018 BMC veterinary research

176. Short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms in NMOSD Full Text available with Trip Pro

Short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms in NMOSD 29484308 2018 11 13 2332-7812 5 3 2018 May Neurology(R) neuroimmunology & neuroinflammation Neurol Neuroimmunol Neuroinflamm Short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms in NMOSD. e447 10.1212/NXI.0000000000000447 Mizuno Yuri Y Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Shinoda Koji (...) Sciences, Kyushu University, Fukuoka, Japan. Kira Jun-Ichi JI Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. eng Journal Article 2018 02 21 United States Neurol Neuroimmunol Neuroinflamm 101636388 2332-7812 2017 10 21 2018 01 05 2018 2 28 6 0 2018 2 28 6 0 2018 2 28 6 1 epublish 29484308 10.1212/NXI.0000000000000447 NEURIMMINFL2017015123 PMC5822750 Cephalalgia. 2006 Feb;26(2):221-4 16426279 Mult Scler. 2014 Jun;20(7):843-7

2018 Neurology® neuroimmunology & neuroinflammation

177. A novel and safe approach: middle cranial approach for laparoscopic right hemicolon cancer surgery with complete mesocolic excision. (Abstract)

A novel and safe approach: middle cranial approach for laparoscopic right hemicolon cancer surgery with complete mesocolic excision. Mastering right hemicolectomy techniques using laparoscopy in colorectal cancer surgery is very difficult. Although the long-term prognosis of laparoscopic right hemicolectomy (LRH) and complete mesocolic excision is unquestionable, different surgeons have their own opinions on routes of conducting LRH.LRH surgery is very complex due to the upper abdominal (...) anatomical structure and vascular variation. Therefore, it has been considered the most difficult of all colorectal cancer surgeries. Our innovative middle cranial approach (MCA) was developed to avoid unnecessary injuries and minimize the operative time, thereby reducing the patient's hospital stay and improving their short-term prognosis.We compared 90 colon cancer patients who underwent the MCA between January 2016 and January 2017 with 82 patients who underwent the conventional central approach

2018 Surgical endoscopy

178. Characteristics, outcome and treatments with cranial pachymeningitis: A multicenter French retrospective study of 60 patients. Full Text available with Trip Pro

, female/male ratio 0.43). Neurologic signs were present in 59 patients (98%) and consisted of headache in 43 (72%), cranial nerve palsy in 33 (55%), confusion in 10 (17%), seizures in 7 (12%), and focal neurologic signs in 9 (15%). Fever and weight loss were present in 8 (13%) and 13 cases (22%), respectively. Cerebral venous thrombosis was present in 8 cases (13%). Analysis of cerebrospinal fluid showed moderate hyperproteinorachia (median 0.68 g/L; IQR 0.46-3.2) with or without pleiocytosis (...) Characteristics, outcome and treatments with cranial pachymeningitis: A multicenter French retrospective study of 60 patients. The aim of this study was to determine the characteristics, treatment, and outcome according to each etiology of pachymeningitis.We conducted a retrospective multicenter French nationwide study between 2000 and 2016 to describe the characteristics, outcome, and treatment of pachymeningitis.We included 60 patients (median age 55.5 years; interquartile range [IQR] 30-80

2018 Medicine

179. Involvement of Calvarial Stem Cells in Healing: A Regional Analysis of Large Cranial Defects. Full Text available with Trip Pro

Involvement of Calvarial Stem Cells in Healing: A Regional Analysis of Large Cranial Defects. Large craniofacial defects present a substantial clinical challenge that often requires the use of osteoconductive matrices and osteoinductive cues (i.e., bone morphogenetic proteins [BMP2]) to augment healing. While these methods have improved clinical outcomes, a better understanding of how the osteogenic fronts surrounding the defect, the underlying dura mater, and the cranial suture area contribute (...) to healing may lead to more targeted therapies to enhance bone regeneration. We hypothesized that healing within a large bone defect will be precipitated from cells within the remaining or available suture mesenchyme abutting the edges of a murine critical sized defect. To investigate this hypothesis, 39 adult, wild-type mice were randomly arranged into groups (9 or 10 per group) by time (4 and 8 weeks) and treatment (control, acellular collagen sponge alone, or acellular collagen sponge loaded

2018 Wound Repair and Regeneration

180. Penetration of the blood-brain barrier by avitinib and its control of intra/extra-cranial disease in non-small cell lung cancer harboring the T790M mutation. (Abstract)

Penetration of the blood-brain barrier by avitinib and its control of intra/extra-cranial disease in non-small cell lung cancer harboring the T790M mutation. Avitinib is an oral, potent, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor selective for the EGFR T790 M mutation. We report the safety, intra-/extracranial efficacy, and the blood-brain barrier (BBB) penetration rate of avitinib (NCT02330367).Non-small cell lung cancer (NSCLC) patients with the EGFR T790 M (...) ) and 536 days (95%CI: 363.6-708.4), respectively. The median intracranial PFS of seven brain metastases patients was 142 days (95% CI 31.1-252.9). Blood and cerebrospinal fluid analysis of five brain metastases patients showed the BBB penetration rate to be 0.046%-0.146%. The most frequent adverse events were mild and reversible hepatic transaminases elevating (10/16, 62.5%) and diarrhea (4/16, 25.0%).Avitinib is well tolerated and efficacious in T790M-positive patients. Its penetrability to the BBB is weak

2018 Lung Cancer

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