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Cranial Nerve 10

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121. Third, Fourth, and Sixth Cranial Nerve Palsies in Pituitary Apoplexy Full Text available with Trip Pro

Third, Fourth, and Sixth Cranial Nerve Palsies in Pituitary Apoplexy Pituitary apoplexy (PA) often presents with acute headache and neuro-ophthalmic manifestations, including ocular motility dysfunction (OMD) from cranial nerve palsies (CNPs). Our goal was to describe the epidemiology and outcomes of OMD in a large, single-center series of patients with PA.We conducted a retrospective chart review of all patients with PA seen in our pituitary center between January 1995 and December 2012

2016 World neurosurgery

122. Multimodal Navigation in Endoscopic Transsphenoidal Resection of Pituitary Tumors using Image-based Vascular and Cranial Nerve Segmentation: A Prospective Validation Study Full Text available with Trip Pro

Multimodal Navigation in Endoscopic Transsphenoidal Resection of Pituitary Tumors using Image-based Vascular and Cranial Nerve Segmentation: A Prospective Validation Study Transsphenoidal surgery (TSS) is the most common approach for the treatment of pituitary tumors. However, misdirection, vascular damage, intraoperative cerebrospinal fluid leakage, and optic nerve injuries are all well-known complications, and the risk of adverse events is more likely in less-experienced hands (...) of the navigation probe or Doppler probe on or as close as possible to the target.Preoperative segmentation of the internal carotid artery and cavernous sinus matched with the intraoperative endoscopic and micro-Doppler findings in all cases. Excellent correspondence between image-based segmentation and the endoscopic view was also evident at the surface of the tumor and at the tumor-normal gland interfaces. Image guidance assisted the surgeons in localizing the optic nerve and chiasm in 64% of cases. The mean

2016 World neurosurgery

123. Involvement of cranial nerves in a patient with secondary central nervous system lymphoma Full Text available with Trip Pro

Involvement of cranial nerves in a patient with secondary central nervous system lymphoma 27208575 2016 05 22 2018 11 13 1516-8484 38 2 2016 Apr-Jun Revista brasileira de hematologia e hemoterapia Rev Bras Hematol Hemoter Involvement of cranial nerves in a patient with secondary central nervous system lymphoma. 158-60 10.1016/j.bjhh.2016.02.001 S1516-8484(16)00024-4 Dantas Azevedo Roberta R Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil. Reis Fabiano F Universidade Estadual

2016 Revista brasileira de hematologia e hemoterapia

124. Cranial Nerves Tractography

Cranial Nerves Tractography Cranial Nerves Tractography - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cranial Nerves Tractography (CN Tracto) The safety and scientific validity of this study (...) Description Go to Brief Summary: Introduction: The skull base tumors surgery remains a challenge since numerous cranial nerves or vessels closely surround them. Recently, diffusion tensor imaging has developed with the tractography following white fibers and visualizing functional tracts. Cranial nerves tractography could allow predicting their displacement by skull base tumors that may help the surgeon to spare them along the surgery. Methods: Preoperative cerebral MRI was performed on patients who

2016 Clinical Trials

125. Cerebrospinal fluid dissemination of anaplastic intraventricular meningioma: report of a case presenting with progressive brainstem dysfunction and multiple cranial nerve palsies. Full Text available with Trip Pro

Cerebrospinal fluid dissemination of anaplastic intraventricular meningioma: report of a case presenting with progressive brainstem dysfunction and multiple cranial nerve palsies. It is extremely rare to see cerebrospinal fluid dissemination of intraventricular meningioma, particularly with the development of acute, progressive brainstem/cerebellar dysfunction with an absence of mass formation in the corresponding anatomical sites.An 81-year-old man was admitted because of double vision, right (...) facial nerve palsy and truncal ataxia. Brain magnetic resonance imaging showed normal findings except for a tumor mass in the left lateral ventricle, which had been noted over 6 months previously. The patient developed hiccups, hyperventilation, and drowsiness, which worsened progressively, and did not respond to corticosteroid or intraventricular immunoglobulin therapy. Cerebrospinal fluid study revealed a mild elevation of protein, and cytology was negative. The patient died and an autopsy

2016 BMC Neurology

126. Third Cranial Nerve Palsy in the Setting of Chikungunya Virus Infection. Full Text available with Trip Pro

Third Cranial Nerve Palsy in the Setting of Chikungunya Virus Infection. We report the case of a 62-year-old patient who developed an acute painless isolated left third cranial nerve palsy sparing the pupil in the setting of an acute chikungunya infection. The patient had no significant medical history. Specifically, he had no vascular risk factors. Ocular involvement in chikungunya fever is uncommon. The potential virus- and infection-related mechanisms of this third cranial nerve palsy

2016 American Journal of Tropical Medicine & Hygiene

127. A frontal external ventricular drain causing a third cranial nerve palsy. (Abstract)

A frontal external ventricular drain causing a third cranial nerve palsy. This 47-year-old gentleman presented with acute hydrocephalus secondary to a colloid cyst. Bilateral external ventricular drains (EVDs) were inserted. The patient developed a third nerve palsy during post-operative period - cranial imaging demonstrated the tip of an EVD in this vicinity. The palsy recovered completely on slight withdrawal of the EVD.

2016 British Journal of Neurosurgery

128. Computer tomographic comparison of cranial spread of contrast in lumbosacral and sacrococcygeal epidural injections in dog cadavers. (Abstract)

coverage, %).The cranial spread of contrast was similar at 0.1 mL kg-1 [1 (0-3) versus 2 (1-3) n], 0.2 mL kg-1 [3 (0-10) versus 3 (1-5) n], 0.4 mL kg-1 [12 (9-18) versus 11 (3-19) n] and 0.6 mL kg-1 [18 (12-20) versus 15 (10-23) n] for the LS and SCo injections, respectively (p = 0.945). There was a significant interaction between the volume injected and vertebral canal coverage (p < 0.001).The cranial spread of contrast was similar, independent of whether the epidural injection was performed in the LS (...) Computer tomographic comparison of cranial spread of contrast in lumbosacral and sacrococcygeal epidural injections in dog cadavers. To compare the cranial spread of epidural injectates between lumbosacral (LS) and sacrococcygeal (SCo) approaches in order to guide volume selection for SCo epidural anaesthesia in the dog.Prospective, randomized cadaveric experimental study.A group of 13 adult greyhound cadavers.The greyhound cadavers were randomly allocated to receive an epidural injection

2019 Veterinary anaesthesia and analgesia Controlled trial quality: uncertain

129. Efficacy of Cranial Electrical Stimulation and Rational Emotive Behavior Therapy in Improving Psychological Illness among Chronic Stroke Survivors: A Pilot Randomized Controlled Trial. Full Text available with Trip Pro

Efficacy of Cranial Electrical Stimulation and Rational Emotive Behavior Therapy in Improving Psychological Illness among Chronic Stroke Survivors: A Pilot Randomized Controlled Trial. Stroke survivors suffer from significant neuropsychiatric disturbances and these disturbances act as barrier in the motor recovery. Medication is the common treatment but it has adverse effects. Hence, there is a need to find out effective treatments with or without minimal side effects for gross motor recovery (...) of the patient.Cranial electrical stimulation (CES) and rational emotive behavior therapy (REBT) are used as treatment approaches for depression, anxiety, stress, and irrational beliefs in the general population. In the present study, the efficacy of two psycho-therapeutic modalities (CES and REBT) along with conventional physiotherapy management was evaluated on psychological illness, motor recovery, and quality of life among chronic stroke (CS) survivors.A total of 18 patients with CS who scored >10 on Beck

2019 Annals of Indian Academy of Neurology Controlled trial quality: uncertain

130. The clinical outcomes for chordomas in the cranial base and spine: A single center experience. Full Text available with Trip Pro

The clinical outcomes for chordomas in the cranial base and spine: A single center experience. Owing to the special growth pattern of chordomas and the limited treatment options currently available, the treatment of chordoma still remains difficult. In this study, we hope to further clarify the relationship between surgical treatment and radiotherapy of chordoma and disease progression.All patients with a primary histopathological diagnosis of clival or spinal chordomas recorded in our (...) institution between 1976 and 2017 were examined.A total of 60 patients (location: skull base/clival, n = 24; vertebral column, n = 5; sacrum, n = 31) had a mean follow-up time of 7.7 years (range 12 months-35 years). Compared with patients who received subtotal resection (n = 5, 5-year and 10-year survival = 61% and 39%, respectively), the annual survival rate of patients who received total resection (n = 55, 5-year and 10-year survival = 67%, respectively) was significantly higher. The overall 10-year

2019 Medicine

131. Predictive value of posterior cranial fossa morphology in the decompression of Chiari malformation type I: A retrospective observational study. Full Text available with Trip Pro

Predictive value of posterior cranial fossa morphology in the decompression of Chiari malformation type I: A retrospective observational study. Posterior fossa decompression (PFD) is the standard procedure for the treatment of Chiari malformation type I (CMI). Although most patients have satisfactory surgical outcomes, some show no improvement or even a worsening of symptoms. Patient selection is thought to account for these different surgical outcomes. Our aim was to evaluate the predictive (...) value of the preoperative posterior cranial fossa (PCF) morphology on the efficacy of PFD.Data from 39 CMI patients with CMI-related symptoms who underwent occipital foramen enlargement + C-1 laminectomy + enlarged duraplasty were retrospectively collected from January 2011 to May 2018. The patients were divided into improved and unimproved groups according to the modified Chicago Chiari Outcome Scale. Demographic information and clinical history, including preoperative comorbidities and clinical

2019 Medicine

132. A Bayesian multivariate latent t-regression model for assessing the association between corticosteroid and cranial radiation exposures and cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia: a PETALE study. Full Text available with Trip Pro

A Bayesian multivariate latent t-regression model for assessing the association between corticosteroid and cranial radiation exposures and cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia: a PETALE study. Childhood acute lymphoblastic leukemia (cALL) is the most frequent pediatric cancer. Over the past decades, treatment of cALL has significantly improved, with cure rates close to 90%. However intensive chemotherapy and cranial radiotherapy (CRT) during (...) ) was OR = 1.98 (95% credible interval (CrI): 1.02 to 3.88). LD/CRT level also led to a 0.15 (95% CrI: 0.00 to 0.29) excess risk to develop at least one cardiometabolic complication. Except for obesity, adjusted results for the highest exposure category HD/CRT were generally similar to those for LD/CRT albeit not statistically significant. White blood cell count at diagnosis, a proxy for cALL burden at diagnosis, was found associated with insulin resistance (OR = 1.08 for a 10-unit increase (× 109/L), 95% CrI

2019 BMC medical research methodology

133. Hearing Improvement Following Middle Cranial Fossa Floor Defect Repair Utilizing a Modified Middle Fossa Approach and Reconstructive Techniques. (Abstract)

Hearing Improvement Following Middle Cranial Fossa Floor Defect Repair Utilizing a Modified Middle Fossa Approach and Reconstructive Techniques. Few studies report hearing preservation following middle cranial fossa (MCF) floor defect repair.To investigate audiological outcomes following MCF floor defect repair using a modified MCF suprapetrous approach.Retrospective cohort.Tertiary referral center.Eleven patients, with MCF floor defects.MCF floor defect surgical repairs with either fascia (...) contents from the defect. Five patients had repair with temporalis fascia and split calvarial bone graft, and six patients had repair with fascia only. Follow up audiogram was performed at a mean 7.5 months (range, 0.5-24 mo). There was no recurrent CSF leak during the follow up period. The 10 patients (90.9%, 95% confidence interval [CI] 60.1-100.6) who had complete audiologic data sets demonstrated a mean improvement of 18.86 dB (range, -7.5 to 33.75 dB) in hearing postoperatively. One

2019 Otology and Neurotology

134. Whole-Genome Sequencing of Childhood Cancer Survivors Treated with Cranial Radiation Therapy Identifies 5p15.33 Locus for Stroke: A Report from the St. Jude Lifetime Cohort Study. (Abstract)

Whole-Genome Sequencing of Childhood Cancer Survivors Treated with Cranial Radiation Therapy Identifies 5p15.33 Locus for Stroke: A Report from the St. Jude Lifetime Cohort Study. To identify genetic factors associated with risk of stroke among survivors of childhood cancer treated with cranial radiotherapy (CRT).We analyzed whole-genome sequencing (36.8-fold) data of 686 childhood cancer survivors of European ancestry [median (range), 40.4 (12.4-64.7) years old; 54% male] from the St. Jude (...) Lifetime Cohort study treated with CRT, of whom 116 (17%) had clinically diagnosed stroke. Association analyses (single-variant and Burden/SKAT tests) were performed, adjusting for demographic characteristics and childhood cancer treatment exposures.We identified a genome-wide significant association between 5p15.33 locus and stroke [rs112896372: HR = 2.55; P = 1.42 × 10-8], with a stronger association (HR = 3.68) among survivors treated with CRT dose 25-50 Gray (Gy) and weaker associations among those

2019 Clinical Cancer Research

135. Meningioma Screening with MRI in Childhood Leukemia Survivors Treated with Cranial Radiation. Full Text available with Trip Pro

Meningioma Screening with MRI in Childhood Leukemia Survivors Treated with Cranial Radiation. Radiation-induced meningioma is a known late effect of cranial radiation therapy. Cranial magnetic resonance imaging (MRI) can detect small meningiomas, but its potential value as a screening tool is unknown.MRI was used to screen asymptomatic survivors of childhood acute lymphoblastic leukemia (ALL) treated with cranial radiation therapy ≥10 years previously. The incidence of radiation-induced

2019 Biology and Physics

136. Evaluation of 3D Printed Temporal Bone Models in Preparation for Middle Cranial Fossa Surgery. (Abstract)

Evaluation of 3D Printed Temporal Bone Models in Preparation for Middle Cranial Fossa Surgery. Patient-specific 3D printed models are useful presurgical planning tools because they accurately represent the anatomy and drilling characteristics of the middle cranial fossa (MCF) approach to the internal auditory canal (IAC).The MCF approach to the IAC can be challenging due to variability of the bony architecture along the floor of the middle fossa. Patient-specific 3D printed models may enhance (...) surgeon knowledge of a given patient's anatomy when preparing for MCF surgery.Six temporal bone models were printed from photoacrylic resin based on CT data obtained from cadaveric specimens using a desktop stereolithography 3D printer. Critical structures to avoid injuring, the facial nerve and membranous labyrinth, were modeled as hollow cavities and filled with indicator paint. Two neurotologists each drilled three 3D printed models and the corresponding cadaveric specimens, and then completed a 41

2019 Otology and Neurotology

137. The relevant psychological burden of having a benign brain tumor: a prospective study of patients undergoing surgical treatment of cranial meningiomas. (Abstract)

The relevant psychological burden of having a benign brain tumor: a prospective study of patients undergoing surgical treatment of cranial meningiomas. OBJECTIVEMeningiomas are the most common intracranial neoplasm. Evidence concerning surgical management and outcome is abundant, while the implications for the quality of life (QOL) of a patient confronted with the diagnosis and undergoing surgery are unclear. The authors conducted a prospective study to evaluate QOL in relation to psychological (...) comorbidities comorbidities.METHODSA prospective study of patients undergoing elective surgery for the removal of an intracranial meningioma was performed. The authors evaluated depression (Allgemeine Depressionsskala K score) and anxiety (Post-Traumatic Stress Scale-10 [PTSS-10]; State Trait Anxiety Inventory-State Anxiety and -Trait Anxiety [STAI-S and STAI-T]; and Anxiety Sensitivity Index-3 [ASI-3]) scores before surgery and at 3 and 12 months after surgery. The correlation between preoperative

2019 Journal of Neurosurgery

138. Prophylactic Cranial Irradiation vs Observation in Patients With Locally Advanced Non-Small Cell Lung Cancer: A Long-term Update of the NRG Oncology/RTOG 0214 Phase 3 Randomized Clinical Trial. (Abstract)

Prophylactic Cranial Irradiation vs Observation in Patients With Locally Advanced Non-Small Cell Lung Cancer: A Long-term Update of the NRG Oncology/RTOG 0214 Phase 3 Randomized Clinical Trial. Brain metastasis (BM) rates are high in locally advanced non-small cell lung cancer (LA-NSCLC), approaching rates seen in small cell lung cancer, where prophylactic cranial irradiation (PCI) is standard of care. Although PCI decreases the incidence of BM in LA-NSCLC, a survival advantage has not yet been (...) randomized.Observation vs PCI.The primary outcome was overall survival (OS). The secondary end points were disease-free survival (DFS) and incidence of BM.Of the 340 total participants, mean (SD) age was 61 years; 213 of the participants were men and 127 were women. The median follow-up time was 2.1 years for all patients, and 9.2 years for living patients. The OS for PCI was not significantly better than observation (hazard ratio [HR], 0.82; 95% CI, 0.63-1.06; P = .12; 5- and 10-year rates, 24.7% and 17.6% vs 26.0

2019 JAMA oncology Controlled trial quality: predicted high

139. Malignant Peripheral Nerve Sheath Tumor of the C2 Nerve Root: Case Report Full Text available with Trip Pro

Malignant Peripheral Nerve Sheath Tumor of the C2 Nerve Root: Case Report Here we present the case of a 36-year-old man who was found to have a symptomatic malignant neural sheath tumor growing from the C2 nerve root following a period of progressively worsening headaches. The patient was successfully treated with surgical resection resulting in resolution of cranial nerve deficits. Though uncommon, malignant peripheral nerve sheath tumor must be considered in the differential diagnosis (...) of tumors involving the cervical nerve roots and carotid space.

2017 Journal of neurological surgery reports

140. Topographical study of the trapezius muscle, greater occipital nerve, and occipital artery for facilitating blockade of the greater occipital nerve. Full Text available with Trip Pro

. The piercing points and the courses of the greater occipital nerve and occipital artery were analyzed by dividing a line connecting between the external occipital protuberance and mastoid process into three equal parts. A circle with a radius of 2 cm drawn at the medial trisection point of this line was divided into four equal sectors. The greater occipital nerve simply passed the lateral border of the trapezius muscle and then pierced the fascia connecting the cranial attachment of the trapezius muscle (...) Topographical study of the trapezius muscle, greater occipital nerve, and occipital artery for facilitating blockade of the greater occipital nerve. The aim of this study was to clarify the topographical relationships between the greater occipital nerve and the trapezius muscle and between the greater occipital nerve and the occipital artery in the occiput in order to increase the success rate of greater occipital nerve blockade. Fifty-six halved heads of 28 cadavers were used in this study

2018 PLoS ONE

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