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Cranial Nerve 10

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9981. [Usefulness of tranexamic acid in cranial remodeling surgery]. (Abstract)

[Usefulness of tranexamic acid in cranial remodeling surgery]. To assess the usefulness of tranexamic acid (TA) in pediatric cranial remodeling surgery, by analyzing its effects on bleeding and transfusion requirements, number of days of cranial drainage required, and time spent in the postoperative recovery unit.A single-blind, controlled study was designed with 20 patients (10 cases and 10 controls) randomly assigned to receive or not receive 15 mg/kg of intravenous TA upon anesthetic (...) surgery. TA group patients also spent less time in the recovery unit (60 +/- 14 vs 72 +/- 11 hours). Blood test variables in TA-treated children were also better 24 hours after surgery with regard to hemoglobin (12.1 +/- 2 vs 11.6 +/- 1.3 mg/dL) and platelet (261 +/- 68.5 vs 181.6 +/- 58.1 platelets/mm3) concentrations, and cephalin time (33 +/- 12 vs 49 +/- 16 seconds). No complications related to TA treatment were observed.TA can reduce perioperative bleeding in the context of pediatric cranial

2003 Revista española de anestesiología y reanimación Controlled trial quality: uncertain

9982. BFM-oriented treatment for children with acute lymphoblastic leukemia without cranial irradiation and treatment reduction for standard risk patients: results of DCLSG protocol ALL-8 (1991-1996). (Full text)

BFM-oriented treatment for children with acute lymphoblastic leukemia without cranial irradiation and treatment reduction for standard risk patients: results of DCLSG protocol ALL-8 (1991-1996). Modern treatment strategies, consisting of intensive chemotherapy and cranial irradiation, have remarkably improved the prognosis for children with acute lymphoblastic leukemia. However, patients with a potential for cure are at risk of severe acute and late adverse effects of treatment. Furthermore (...) , in 25-30% of patients treatment still fails. The objectives of the DCLSG study ALL 8 were to decrease the toxicity and to increase the effectivity of BFM-oriented treatment. Decrease of toxicity was aimed at by confirmation of the results of the previous DCLSG study ALL-7, showing that the majority (94%) of children with ALL can successfully be treated with BFM-oriented therapy without cranial irradiation, and by reduction of treatment for standard risk (SRG) patients. To increase the cure rate

2002 Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K Controlled trial quality: uncertain PubMed abstract

9983. Cranial MRI scans are indicated in all girls with central precocious puberty. (Full text)

age of onset of puberty was 6.2 years (range 2.0-7.9). Intracranial abnormalities were present in 10 (15%) patients (MR+), while 57 (85%) had no abnormalities (MR-). There was no statistical difference between MR+ patients and MR- patients at presentation with respect to age of onset of puberty, pubertal stage, bone age advance, pelvic ultrasound findings, or height or body mass index standard deviation scores (SDS).Girls with CPP should have a cranial MRI scan as part of their assessment since (...) Cranial MRI scans are indicated in all girls with central precocious puberty. (1) To assess the value of cranial magnetic resonance imaging (MRI) scans in the investigation of girls with central precocious puberty (CPP); and (2) to determine the clinical predictors of abnormal cranial MRI scans in these patients.A retrospective study of 67 girls diagnosed with CPP who underwent cranial MRI scans at diagnosis. Patients with neurological signs or symptoms at presentation were excluded.The mean

2003 Archives of Disease in Childhood PubMed abstract

9984. Microsurgical anatomy of the perigeniculate ganglion area as seen from the middle cranial fossa approach. (Abstract)

Microsurgical anatomy of the perigeniculate ganglion area as seen from the middle cranial fossa approach. The middle cranial fossa approach is useful for decompressing the perigeniculate ganglion area of the facial nerve in patients with serviceable hearing. The present study was designed to investigate the microsurgical anatomy of the perigeniculate ganglion area of the facial nerve from the point of view of the middle cranial fossa. We dissected 20 human temporal bones under a microscope (...) using a middle fossa approach, and measured the angle between the lines drawn from the malleus head to the vertical crest and from the malleus head to the geniculate ganglion, and the distance from the malleus head to the geniculate ganglion. These were found to be 22.7 degrees +/- 2.2 degrees and 6.5 +/- 0.3 mm, respectively. Detailed knowledge about the microsurgical anatomy of the perigeniculate ganglion area of the facial nerve from the point of view of the middle cranial fossa is imperative

2003 Rhinology and Laryngology

9985. RSR13 plus cranial radiation therapy in patients with brain metastases: comparison with the Radiation Therapy Oncology Group Recursive Partitioning Analysis Brain Metastases Database. (Abstract)

Analysis Brain Metastases Database (RTOG RPA BMD).Eligibility criteria were age > or = 18 years, Karnofsky performance score > or = 70, and brain metastases with solid tumor histology. Patients received cranial RT, 30 Gy in 10 fractions of 3 Gy each, preceded by RSR13, 50 to 100 mg/kg intravenously over 30 minutes. Univariate and multivariate comparisons of survival and cause of death were made between class II study patients and RTOG BMD patients.Fifty-seven RPA class II patients were enrolled (...) RSR13 plus cranial radiation therapy in patients with brain metastases: comparison with the Radiation Therapy Oncology Group Recursive Partitioning Analysis Brain Metastases Database. This phase II, open-label, multicenter study assessed the efficacy and safety of the potential radiation enhancer RSR13 plus cranial radiation therapy (RT) in patients with brain metastases. The primary end point was patient survival in comparison with the Radiation Therapy Oncology Group Recursive Partitioning

2003 Journal of Clinical Oncology

9986. The effect of cranial manipulation on the Traube-Hering-Mayer oscillation as measured by laser-Doppler flowmetry. (Abstract)

The effect of cranial manipulation on the Traube-Hering-Mayer oscillation as measured by laser-Doppler flowmetry. A correlation has been established between the Traube-Hering-Mayer oscillation in blood-flow velocity, measured by laser-Doppler flowmetry, and the cranial rhythmic impulse.To determine the effect of cranial manipulation on the Traube-Hering-Mayer oscillation.Of 23 participants, 13 received a sham treatment and 10 received cranial manipulation.Osteopathic Manipulative Medicine (...) Department, Midwestern University, Downers Grove, Ill.Healthy adult subjects of both sexes participated (N = 23).A laser-Dopper flowmetry probe was placed on the left earlobe of each subject to obtain a 5-min baseline blood-flow velocity record. Cranial manipulation, consisting of equilibration of the global cranial motion pattern and the craniocervical junction, was then applied for 10 to 20 min; the sham treatment was palpation only.Immediately following the procedures, a 5-min posttreatment laser

2002 Alternative Therapies in Health & Medicine

9987. CARD15 mutations in familial granulomatosis syndromes: a study of the original Blau syndrome kindred and other families with large-vessel arteritis and cranial neuropathy. (Abstract)

CARD15 mutations in familial granulomatosis syndromes: a study of the original Blau syndrome kindred and other families with large-vessel arteritis and cranial neuropathy. To analyze the CARD15 gene in families with heritable multi-organ granulomatoses, including the original Blau syndrome kindred as well as other families with related granulomatous conditions.Linkage mapping was performed in 10 families. Observed recombination events were used to exclude regions centromeric or telomeric (...) for the R334W missense mutation; mutations at the same position were also observed in several unrelated Blau syndrome families, some of whose phenotypes included large-vessel arteritis and cranial neuropathy. The missense mutations segregated with the disease phenotype in the families, and were not seen in 208 control alleles.These findings demonstrate that CARD15 is an important susceptibility gene for Blau syndrome and for other familial granulomatoses that display phenotypic traits beyond those

2002 Arthritis and Rheumatism

9988. Practice guideline on prophylactic cranial irradiation in small-cell lung cancer. (Abstract)

Practice guideline on prophylactic cranial irradiation in small-cell lung cancer. To develop an evidence-based clinical practice guideline that would address the following questions: (a) What is the role of prophylactic cranial irradiation (PCI) in patients with limited or extensive stage small-cell lung cancer (SCLC) who have achieved complete remission in response to induction therapy (chemotherapy or chemoradiotherapy)? (b) What dose and fractionation schedules of PCI are optimal? (c) Does (...) after induction therapy, there is evidence of a disease-free survival benefit (4 of 6 trials) and an overall survival benefit (meta-analysis). There is insufficient evidence to make a definitive recommendation with respect to dose. There is some indication that 30-36 Gy in 2-3 Gy per fraction, or a biologically equivalent dose, may produce a better outcome than a lower dose or less aggressive fractionation regimen. The schedule commonly used in Canada is 25 Gy in 10 fractions over 2 weeks. Data from

2001 International journal of radiation oncology, biology, physics

9989. Cranial electrostimulation for headache: meta-analysis. (Abstract)

Cranial electrostimulation for headache: meta-analysis. 9442190 1998 02 03 2019 07 24 0022-3018 185 12 1997 Dec The Journal of nervous and mental disease J. Nerv. Ment. Dis. Cranial electrostimulation for headache: meta-analysis. 766-7 McCrory D C DC eng Comment Letter United States J Nerv Ment Dis 0375402 0022-3018 AIM IM J Nerv Ment Dis. 1995 Jul;183(7):478-84 7623022 Electric Stimulation Therapy Headache therapy Humans Meta-Analysis as Topic Migraine Disorders therapy Research Design

1998 The Journal of nervous and mental disease

9990. MRSA with progression from otitis media and sphenoid sinusitis to clival osteomyelitis, pachymeningitis and abducens nerve palsy in an immunocompetent 10-year-old patient. (Abstract)

MRSA with progression from otitis media and sphenoid sinusitis to clival osteomyelitis, pachymeningitis and abducens nerve palsy in an immunocompetent 10-year-old patient. A previously healthy 10-year-old patient with headache, otalgia, and hearing loss was diagnosed with pachymeningitis and methicillin-resistant Staphylococcus aureus otitis media and bacteremia. Despite antimicrobial therapy, intracranial extension progressed, including clival osteomyelitis, sphenoid sinusitis, cavernous sinus (...) inflammation and cranial nerve palsies, until the sphenoid sinus was drained. This case exemplifies an aggressive MRSA intracranial infection that advanced despite antibiotic therapy.

2008 International Journal of Pediatric Otorhinolaryngology

9991. Cornichon-like Protein Facilitates Secretion of HB-EGF and Regulates Proper Development of Cranial Nerves (Full text)

Cornichon-like Protein Facilitates Secretion of HB-EGF and Regulates Proper Development of Cranial Nerves During their migration to the periphery, cranial neural crest cells (NCCs) are repulsed by an ErbB4-dependent cue(s) in the mesenchyme adjoining rhombomeres (r) 3 and 5, which are segmented hindbrain neuromeres. ErbB4 has many ligands, but which ligand functions in the above system has not yet been clearly determined. Here we found that a cornichon-like protein/cornichon homolog 2 (CNIL (...) /CNIH2) gene was expressed in the developing chick r3 and r5. In a cell culture system, its product facilitated the secretion of heparin-binding epidermal growth factor-like growth factor (HB-EGF), one of the ligands of ErbB4. When CNIL function was perturbed in chick embryos by forced expression of a truncated form of CNIL, the distribution of NCCs was affected, which resulted in abnormal nerve fiber connections among the cranial sensory ganglia. Also, knockdown of CNIL or HB-EGF with siRNAs yielded

2007 Molecular biology of the cell PubMed abstract

9992. Is migraine with cranial nerve palsy an ophthalmoplegic migraine? (Full text)

Is migraine with cranial nerve palsy an ophthalmoplegic migraine? Ophthalmoplegic migraine (OM) is a rare form of primary headache. Because of its rarity, only a few cases, mostly symptomatic, are reported. We analyse nine cases among 52 973 adults who suffer from headaches with an oculomotor palsy firstly considered as OM. The study was retrospective and multicentric in a database set up in France. The aim of our investigation was to describe the clinical and radiological aspects (...) of these cases and to discuss the diagnosis of OM. We demonstrate that the characteristics of the headaches were identical to usual migraine without oculomotor nerve palsy for each case. The study emphasises the difficulty of the OM diagnosis even with the new IHS criteria because of the rarity of having all characteristics. A wide heterogeneity was noted in cranial imagery and blood tests. We suggest adding the code of probable OM in the IHS classification to increase the knowledge and detection

2007 The journal of headache and pain PubMed abstract

9993. Efficacy of Endovascular Surgery for Unruptured Internal Carotid Artery Aneurysms Presenting with Cranial Nerve Symptoms (Full text)

Efficacy of Endovascular Surgery for Unruptured Internal Carotid Artery Aneurysms Presenting with Cranial Nerve Symptoms Whether endovascular surgery is able to reduce the mass effects of unruptured aneurysms is still controversial, although some reports have suggested efficacy in cases of internal carotid artery aneurysms with cranial nerve palsy. Here we assessed outcome in a series of cases. Between April 1992 and April 2005, 18 patients with unruptured internal carotid artery aneurysms (...) presenting with cranial nerve palsy were treated by endovascular surgery. The patients were two males and 16 females aged from 19 to 84 (mean 59.6 years). Aneurysms were located in the cavernous portion in 14, at the origin of the ophthalmic artery in one and at the origin of P-com in three. The aneurysms were all embolized using Guglielmi detachable coils, Interlocking detachable coils, Cook's detachable coils or Trufill DSC and detachable Balloons were applied to occlude the proximal parent artery.We

2007 Interventional Neuroradiology PubMed abstract

9994. Virtual Cisternoscopy: 3D MRI Models of the Cerebellopontine Angle for Lesions Related to the Cranial Nerves (Full text)

Virtual Cisternoscopy: 3D MRI Models of the Cerebellopontine Angle for Lesions Related to the Cranial Nerves This study was conducted to show that high-resolution magnetic resonance imaging (MRI) can aid in the neurosurgical approach to lesions affecting the cranial nerves (CNs) in the cerebellopontine angle (CPA). Three patients with symptomatology related to CNs VII and VIII underwent MRI examinations performed on a 1.5-Tesla Siemens MR scanner. As part of these routine examinations

2004 Skull Base PubMed abstract

9995. Loss of the Sall3 Gene Leads to Palate Deficiency, Abnormalities in Cranial Nerves, and Perinatal Lethality (Full text)

Loss of the Sall3 Gene Leads to Palate Deficiency, Abnormalities in Cranial Nerves, and Perinatal Lethality Members of the Spalt gene family encode putative transcription factors characterized by seven to nine C2H2 zinc finger motifs. Four genes have been identified in mice--Spalt1 to Spalt4 (Sall1 to Sall4). Spalt homologues are widely expressed in neural and mesodermal tissues during early embryogenesis. Sall3 is normally expressed in mice from embryonic day 7 (E7) in the neural ectoderm (...) and primitive streak and subsequently in the brain, peripheral nerves, spinal cord, limb buds, palate, heart, and otic vesicles. We have generated a targeted disruption of Sall3 in mice. Homozygous mutant animals die on the first postnatal day and fail to feed. Examination of the oral structures of these animals revealed that abnormalities were present in the palate and epiglottis from E16.5. In E10.5 embryos, deficiencies in cranial nerves that normally innervate oral structures, particularly

2004 Molecular and cellular biology PubMed abstract

9996. Imaging the cranial nerves in cancer (Full text)

Imaging the cranial nerves in cancer The cranial nerves are often involved in head and neck malignancies. Some malignancies have a strong propensity to show perineural spread. Cranial nerve palsy may be the presenting sign of metastatic disease to the skull base. Like metastatic disease to the lungs or liver, the cranial nerves themselves may be the site of metastatic disease. In addition, cranial nerves can be injured by radiation therapy or sacrificed during surgical treatment. This paper (...) focuses on the imaging features of perineural infiltration, skull base neural foramen involvement and metastatic disease in the cranial nerves. It will also highlight the complications of radiation therapy, in particular radiation - induced optic neuritis.

2004 Cancer Imaging PubMed abstract

9997. Hemifacial spasm, neuralgia, and syncope due to cranial nerve compression in a patient with vertebral artery ectasia (Full text)

Hemifacial spasm, neuralgia, and syncope due to cranial nerve compression in a patient with vertebral artery ectasia 16227538 2005 11 22 2017 11 14 0022-3050 76 11 2005 Nov Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry Neurological picture. Hemifacial spasm, neuralgia, and syncope due to cranial nerve compression in a patient with vertebral artery ectasia. 1500 Spengos K K Department of Neurology, University of Athens, 11528 Athens, Greece. spengos@hol.gr (...) complications pathology surgery Neuralgia complications etiology Pons pathology Syncope complications etiology Vagus Nerve pathology surgery Vertebral Artery diagnostic imaging pathology 2005 10 18 9 0 2005 12 13 9 0 2005 10 18 9 0 ppublish 16227538 76/11/1500 10.1136/jnnp.2005.064147 PMC1739408

2005 Journal of neurology, neurosurgery, and psychiatry PubMed abstract

9998. Cranial Nerve Injuries and the Retrojugular Approach in Carotid Endarterectomy (Full text)

Cranial Nerve Injuries and the Retrojugular Approach in Carotid Endarterectomy This is a retrospective case series analysis to compare the incidence of cranial nerve injuries in carotid endarterectomy by the retrojugular and anteromedial approaches.Data were extracted from a prospectively collected database. Ninety-one retrojugular carotid endarterectomies were compared with 145 anteromedial carotid endarterectomies. All were performed under local anaesthesia and used the eversion technique (...) . Data were analysed using the chi-squared test.Nine (3.8%) cases were complicated by cranial nerve injuries. In four cases, multiple nerves were involved. In total, 13 (5.5%) cranial nerves were injured. The affected nerves were: two (0.8%) marginal mandibular, two (0.8%) laryngeal, three (1.2%) accessory and six (2.5%) hypoglossal. There was no statistically significant difference in total or specific cranial nerve injuries between the two surgical approaches.The risk of cranial nerve injuries

2008 Annals of the Royal College of Surgeons of England PubMed abstract

9999. An 89-year-old woman with cranial nerve dysfunction: diagnosis by observation (Full text)

An 89-year-old woman with cranial nerve dysfunction: diagnosis by observation 15738486 2005 07 05 2018 11 13 1488-2329 172 5 2005 Mar 01 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ An 89-year-old woman with cranial nerve dysfunction: diagnosis by observation. 632 Milbrandt Kris K Division of Plastic Surgery, Department of Surgery, University of Saskatchewan, Saskatoon, Sask. Classen Dale D eng Case Reports Journal Article Canada CMAJ 9711805 (...) 0820-3946 AIM IM Aged Aged, 80 and over Blindness etiology Carcinoma, Squamous Cell complications diagnosis Cranial Nerve Diseases etiology Female Humans Orbital Neoplasms complications diagnosis Tomography, X-Ray Computed 2005 3 2 9 0 2005 7 6 9 0 2005 3 2 9 0 ppublish 15738486 172/5/632 10.1503/cmaj.1041089 PMC550631 J Neurooncol. 2002 Mar;57(1):37-40 12125965 Br J Plast Surg. 1995 Dec;48(8):564-8 8548157 Surv Ophthalmol. 1987 Sep-Oct;32(2):136-40 3686340

2005 CMAJ : Canadian Medical Association Journal PubMed abstract

10000. Cranial Nerve Preservation in Surgery for Large Acoustic Neuromas (Full text)

Cranial Nerve Preservation in Surgery for Large Acoustic Neuromas Facial nerve outcomes and surgical complication rates for other cranial nerves were evaluated retrospectively after the resection of large acoustic neuromas. The charts of all patients who underwent surgical removal of an acoustic neuroma between 1992 and 2001 at New York University Medical Center were reviewed. Fifty-four patients with tumors measuring 3 cm or larger were included in the study. Four patients had (...) was achieved in 84% of patients. Ultimate facial nerve outcome was excellent after the surgical resection of large acoustic neuromas. Preoperative cranial nerve palsies also improved after surgery. The translabyrinthine approach for tumor removal is our treatment of choice for acoustic neuromas 3 cm or larger.

2004 Skull Base PubMed abstract

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