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Cranial Nerve 10

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9801. Relative roles of microsurgery and stereotactic radiosurgery for the treatment of patients with cranial meningiomas: a single-surgeon 4-year integrated experience with both modalities. (Abstract)

of treatment. Symptoms improved in 48.4% of patients undergoing microsurgery and 16.7% of those who underwent GKS. Transient and permanent cranial nerve morbidity was 7.9 compared with 2.9%, and 5.3 compared with 8.5% for GKS and microsurgery, respectively. In a patient satisfaction survey 93.1% of microsurgery patients and 91.2% of GKS patients were highly satisfied.Both GKS and microsurgery serve important roles in the overall management of patients with meningiomas. Both are safe and effective (...) Relative roles of microsurgery and stereotactic radiosurgery for the treatment of patients with cranial meningiomas: a single-surgeon 4-year integrated experience with both modalities. The authors sought to assess the respective roles of microsurgery and gamma knife surgery (GKS) in the treatment of patients with meningiomas.The authors culled from a 4-year prospective database data on 74 cases of meningiomas. Thirty-eight were treated with GKS and 35 with microsurgery. Simpson Grade 1 or 2

2005 Journal of Neurosurgery

9802. A superciliary approach for anterior cranial fossa lesions in children. Technical note. Full Text available with Trip Pro

x 3-cm bone opening just above the eyebrow through a superciliary incision, has been previously described in adults for many lesions situated in the anterior cranial fossa, including tumors and aneurysms. The authors review their experience in using this approach in 27 children for a variety of intracranial lesions. This approach was used for 28 procedures in children ranging in age from 1 to 16 years (mean age 10 years). The lesions included arachnoid cysts, cerebrospinal fluid fistulas (...) A superciliary approach for anterior cranial fossa lesions in children. Technical note. Many subfrontal and orbitofrontal craniotomy techniques have been proposed and developed for anterior cranial fossa lesions. The purpose of this study was to evaluate the surgical experience with the frontolateral keyhole craniotomy through a superciliary skin incision in children. The keyhole craniotomy is a modification of the traditional pterional approach. This modified approach, a craniotomy with a 2.5

2005 Journal of Neurosurgery

9803. Using the processus cochleariformis as a multipurpose landmark in middle cranial fossa surgery. (Abstract)

cochleariformis to inner-ear structures, and to define 14 other measurements that relate inner-ear structures to adjacent structures within the intact bone.Using 10 cadaver specimens, 20 reproducible measurements were defined. The first six of these defined the relation of the processus cochleariformis to inner-ear structures in the middle cranial fossa approach. The other measurements defined the exact location of the inner-ear structures and adjacent structures within the intact bone.The vertical crest lies (...) cochleariformis to the coronal plane. The other measurements obtained give important clues about the position of the cochlea, vestibulum, greater superficial petrosal nerve and labyrinthine segment of the facial nerve.If the classical landmarks are indiscernible during middle cranial fossa surgery, then the processus cochleariformis, with its intimate and constant relationships to inner-ear structures, is a safe and constant landmark.

2008 Journal of Laryngology & Otology

9804. A case of cranial fasciitis masquerading as acute mastoiditis. (Abstract)

A case of cranial fasciitis masquerading as acute mastoiditis. We report a case of infection against a background of pre-existing cranial fasciitis.Case report and review of world literature on cranial fasciitis.Cranial fasciitis of childhood is a benign condition and a rare variant of nodular fasciitis. We present the case of a 10-week-old infant with symptoms and signs consistent with a subperiosteal abscess complicating acute mastoiditis. Subsequent findings showed this to be an infection (...) against a background of pre-existing cranial fasciitis.To our knowledge, this is the first such reported case in the literature. Knowledge of the distinctive histopathological features, coupled with an awareness of the condition, are crucial to establishing a definitive diagnosis of cranial fasciitis and, in turn, to instituting appropriate management. The aetiopathogenesis of the condition remains unclear.

2008 Journal of Laryngology & Otology

9805. Otogenic Cranial Base Osteomyelitis: A Proposed Prognosis-Based System for Disease Classification. (Abstract)

Charlson comorbidity score was 5, and 63% of patients were diabetic. The most common presenting symptoms were pain and otorrhea, and 8 patients had cranial nerve neuropathy. Pseudomonas aeruginosa was the most common bacterial pathogen (n = 28; 74%), and 9 patients had fungal or mixed infections. On average, antibiotics were administered for 161 days, and 6 patients had concomitant surgery. The average follow-up was 33 months, and 3-year disease-specific survival was 76%. Univariate predictors (...) of survival were the SPECT grade, fungal/mixed infections, Charlson score, immune compromise, and cranial nerve neuropathy. The only independent predictor of survival on multivariate Cox regression was the SPECT stage at presentation.Cranial base osteomyelitis is associated with significant morbidity and mortality and requires prolonged treatment. Long-term outcome can be predicted from the initial SPECT scan.

2008 Otology and Neurotology

9806. Systemic chemotherapy after cranial irradiation in patients with brain metastases from non-small cell lung cancer: A retrospective study. (Abstract)

Systemic chemotherapy after cranial irradiation in patients with brain metastases from non-small cell lung cancer: A retrospective study. Brain metastases (BMs) are found in about 10% of patients with newly diagnosed non-small cell lung cancer (NSCLC). This retrospective study was conducted to assess the clinical outcomes and prognostic factors of patients who received chemotherapy after cranial irradiation for NSCLC with synchronous BMs.From January 2000 through July 2007, we reviewed (...) the medical records of patients who received systemic chemotherapy following cranial irradiation for BMs from newly diagnosed NSCLC.A total of 40 patients were included in this review. As the first-line chemotherapy, a total of 114 cycles were administered, for a median number of 2 cycles per patient (range, 0.5-8 cycles). Thirty-four patients (85%) received platinum-based combination regimen and the remaining 6 received chemotherapy with a single agent. Sixteen (40%) patients, 11 of whom had ECOG of 2

2008 Lung Cancer

9807. A True Minimally Invasive Approach for Cochlear Implantation: High Accuracy in Cranial Base Navigation Through Flat-Panel-Based Volume Computed Tomography. (Abstract)

A True Minimally Invasive Approach for Cochlear Implantation: High Accuracy in Cranial Base Navigation Through Flat-Panel-Based Volume Computed Tomography. High-precision intraoperative navigation using high-resolution flat-panel volume computed tomography makes feasible the possibility of minimally invasive cochlear implant surgery, including cochleostomy. Conventional cochlear implant surgery is typically performed via mastoidectomy with facial recess to identify and avoid damage to vital (...) functional important structures (e.g., facial nerve, chorda tympani, incus).Postoperatively, computed tomographic imaging and conventional surgical exploration of the drilled route to the cochlea were performed.All 4 specimens showed a cochleostomy located at the scala tympani anterior inferior to the round window. The chorda tympani was damaged in 1 specimen--this was preoperatively planned as a narrow facial recess was encountered.Using flat-panel volume computed tomography for image-guided surgical

2007 Otology and Neurotology

9808. Malignant myoepithelioma of cranial dura. (Abstract)

Malignant myoepithelioma of cranial dura. Malignant tumors of myoepithelial origin have been increasingly recognized at a variety of sites. Herein, we describe an example of malignant myoepithelioma arising in intracranial dura. The patient is a 47-year-old woman who presented with intracranial hemorrhage and on magnetic resonance imaging was found to have an enhancing tumor. No extracranial primary tumor was identified. A gross total resection was performed. Histologically, it varied (...) in pattern from diffuse to focally (<10%) ductular and consisted of epitheloid to spindle cells showing marked mitotic activity. Prominent infiltration of the dura was noted. Immunohistochemical stains showed convincing expression of cytokeratins (AE1/AE3 and CAM 5.2), S-100 protein, smooth muscle actin, and glial fibrillary acidic protein. Electron microscopy performed on formalin-fixed, paraffin-embedded tissue demonstrated cohesive cells with focal intermediate filament content and surface basal

2007 American Journal of Surgical Pathology

9809. Osteopontin and bone metabolism in healing cranial defects in rabbits. (Abstract)

Osteopontin and bone metabolism in healing cranial defects in rabbits. Non-collagen proteins such as bone sialoprotein and osteopontin (OPN) form 10% of the extracellular bone matrix. In this study, the influence of OPN on bone repair was investigated. Human OPN (Innogenetics) was produced by a recombinant technique and bonded onto the surface of hydroxyapatite (Interpore 200). Thirty rabbits were divided into six equal groups. A circular defect (10mm) was prepared in each parietal bone

2006 International Journal of Oral and Maxillofacial Surgery

9810. Mannitol but not dantrolene prevents myocardial dysfunction following intra-cranial hypertension in rats. Full Text available with Trip Pro

Mannitol but not dantrolene prevents myocardial dysfunction following intra-cranial hypertension in rats. Cardiac complications stemming from intra-cranial hypertension may result from impaired intra-cellular Ca(2+) homeostasis. The aim of this study was to examine the effects of dantrolene, a blocker of sarcoplasmic reticulum (SR) Ca(2+) release, on myocardial dysfunction associated with intra-cranial hypertension in rats. Dantrolene (10 mg) with and without 15% mannitol was administered (...) to halothane-anesthetized rats prior to induction of intra-cranial hypertension by subdural balloon inflation. Its effects were compared to 3% and 15% mannitol and 5% Pentaspan. Dantrolene with mannitol or 15% mannitol alone prevented the transient intra-cranial hypertension-induced hyperdynamic response and ensuing circulatory collapse that was found in animals pre-treated with 3% mannitol solution or pentaspan. Moreover, hemodynamic function was preserved irrespective of TnI cleavage. However, only

2005 American Journal of Transplantation

9811. Sensitivity of Noncontrast Cranial Computed Tomography for the Emergency Department Diagnosis of Subarachnoid Hemorrhage. (Abstract)

, 2001, to December 31, 2004, with spontaneous subarachnoid hemorrhage. We determined whether patients were diagnosed by cranial CT or lumbar puncture, the presence of headache and level of consciousness at ED presentation, and whether or not they had an aneurysm or arteriovenous malformation.We identified 149 patients who were diagnosed with spontaneous subarachnoid hemorrhage during the study period. Noncontrast cranial CT scan diagnosed 139 patients, and 10 were diagnosed with lumbar puncture (...) Sensitivity of Noncontrast Cranial Computed Tomography for the Emergency Department Diagnosis of Subarachnoid Hemorrhage. Emergency physicians use noncontrast cranial computed tomographic (CT) imaging of headache patients to identify subarachnoid hemorrhage caused by aneurysms or arteriovenous malformations. Given sufficiently high sensitivity, CT imaging could be used as a definitive diagnostic study in these patients. The purpose of this study is to determine the sensitivity of noncontrast

2008 Annals of Emergency Medicine

9812. Cranial Neuropathy as a Presenting Sign of Recurrent Aggressive Skin Cancer. (Abstract)

with multiple cranial neuropathies. All exhibited neuropathy of the trigeminal nerve (cranial nerve V). The tumors involved were squamous cell carcinoma (4) and melanoma (2). All patients were multiply symptomatic, presenting with a mean of three neurologic symptoms, including facial numbness (5), facial paralysis or weakness (3), facial pain (3), diplopia (3), paresthesia (3), hearing loss (1), or formication (2). Symptoms were present for an average of 7 months prior to diagnosis of perineural recurrence (...) . Cranial nerve involvement was confirmed in all patients by magnetic resonance imaging, and five patients manifested histologic evidence of perineural tumor infiltration. Treatment consisted of various combinations of surgery, radiation, and chemotherapy for five patients, and one patient declined any intervention. Death rate subsequent to disease was 50%, and follow-up has continued within our institution on all patients for an average of 25.5 months (range, 3-72 months).Cranial neuropathy is a rare

2008 Dermatologic Surgery

9813. Neurocognitive function in patients with small cell lung cancer : effect of prophylactic cranial irradiation. Full Text available with Trip Pro

Neurocognitive function in patients with small cell lung cancer : effect of prophylactic cranial irradiation. The use of prophylactic cranial irradiation (PCI) in patients with small cell lung cancer (SCLC) has been tempered by fears of detrimental effects on cognitive function. Neuropsychologic testing was prospectively conducted before and after PCI to evaluate its effects on cognitive function in patients with SCLC.Ninety-six patients who completely or partially responded to initial therapy (...) underwent formal neurocognitive testing before PCI. Three patients who had central nervous system metastasis were excluded. Of the remaining patients, 69 received PCI (mean dose, 25 grays [Gy] in 10 fractions). Repeat testing was performed on 37 patients (median follow-up, 23 months; range, 6-120 months).Baseline impairment was defined as > or =1.5 standard deviations below the normative mean. Before undergoing PCI, 47% of patients had evidence of impaired cognitive function. After PCI, univariate

2007 Cancer

9814. Splitting of the Extraocular Horizontal Rectus Muscle in Congenital Cranial Dysinnervation Disorders. (Abstract)

Splitting of the Extraocular Horizontal Rectus Muscle in Congenital Cranial Dysinnervation Disorders. To analyze the horizontal rectus extraocular muscles (EOMs) by orbital magnetic resonance imaging (MRI) in patients with congenital cranial dysinnervation disorders that arises from abnormal development of cranial nerve nuclei or their axonal connections.Case series, retrospective analysis.The morphology of the horizontal rectus EOMs was analyzed in orbital MRI on 4 patients with congenital (...) , and 1 of the 4 patients (25%) with oculomotor palsy, but in none of the 6 normal subjects and 12 patients with acquired cranial nerve palsy.Since splitting of the horizontal rectus EOMs was noted in patients with congenital dysinnervation disorders, including Duane syndrome, Sevel's theory that the horizontal rectus EOMs develop from the superior and inferior mesodermal complexes is considered to be reasonable.

2008 American Journal of Ophthalmology

9815. Current definitions of hypotension do not predict abnormal cranial ultrasound findings in preterm infants. (Abstract)

catheters in the first 3 days of life. Sequential 5-minute epochs of continuous mean arterial pressure recordings were assigned a mean value and a coefficient of variation. We applied to our data 3 definitions of hypotension in current clinical use and derived a hypotensive index for each definition. We examined the association between these definitions of hypotension and abnormal cranial ultrasound findings between days 5 and 10. In addition, we evaluated the effect of illness severity (Score (...) Current definitions of hypotension do not predict abnormal cranial ultrasound findings in preterm infants. Hypotension is a commonly treated complication of prematurity, although definitions and management guidelines vary widely. Our goal was to examine the relationship between current definitions of hypotension and early abnormal cranial ultrasound findings.We prospectively measured mean arterial pressure in 84 infants who were < or = 30 weeks' gestational age and had umbilical arterial

2007 Pediatrics

9816. Canine cranial cruciate ligament rupture in profile: 2002–2007 Full Text available with Trip Pro

Canine cranial cruciate ligament rupture in profile: 2002–2007 18309752 2008 03 24 2018 11 13 0008-5286 49 2 2008 Feb The Canadian veterinary journal = La revue veterinaire canadienne Can. Vet. J. Canine cranial cruciate ligament rupture in profile: 2002-2007. 193-4 Harasen Greg G Animal Clinic of Regina, 1800 Garnet Street, Regina, Saskatchewan S4T 2Z2. eng Journal Article Canada Can Vet J 0004653 0008-5286 IM Age Factors Animals Anterior Cruciate Ligament Injuries Breeding Canada Dog (...) Diseases epidemiology surgery Dogs Joint Diseases epidemiology surgery veterinary Osteotomy methods veterinary Rupture surgery veterinary Sex Factors Treatment Outcome 2008 3 4 9 0 2008 3 25 9 0 2008 3 4 9 0 ppublish 18309752 PMC2216436 Aust Vet J. 1995 Aug;72(8):281-5 8579557 J Am Vet Med Assoc. 2006 Jan 1;228(1):61-4 16426167 Vet Surg. 1998 Nov-Dec;27(6):533-9 9845216 Can Vet J. 2003 Oct;44(10):845-6 14601687 Can Vet J. 1995 Apr;36(4):250-1 7600520 J Am Vet Med Assoc. 2003 Jan 15;222(2):184-93

2008 The Canadian Veterinary Journal

9817. Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery

. Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00438087 Recruitment Status : Completed First Posted : February 21, 2007 Last Update Posted : July 10, 2012 Sponsor: Assistance Publique - Hôpitaux de Paris Information provided (...) by (Responsible Party): Assistance Publique - Hôpitaux de Paris Study Details Study Description Go to Brief Summary: Facial palsy after surgical removal of cranial base tumors adherent to the nerve can partly be explained by inflammation. Condition or disease Intervention/treatment Phase Facial Palsy Drug: methylprednisolone Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 313 participants Allocation: Randomized Intervention Model

2007 Clinical Trials

9818. Cranial ultrasound as a non‐invasive diagnostic technique in the diagnosis of subdural haemorrhage Full Text available with Trip Pro

Cranial ultrasound as a non‐invasive diagnostic technique in the diagnosis of subdural haemorrhage 17449534 2007 05 09 2018 11 13 1468-2044 92 5 2007 May Archives of disease in childhood Arch. Dis. Child. Cranial ultrasound as a non-invasive diagnostic technique in the diagnosis of subdural haemorrhage. 468 Sert Ahmet A eng Letter Comment England Arch Dis Child 0372434 0003-9888 AIM IM Arch Dis Child. 2005 Sep;90(9):952-5 16113132 Arch Dis Child. 2005 Sep;90(9):947-51 16113131 Age Factors (...) Child Abuse diagnosis Echoencephalography methods Hematoma, Subdural diagnostic imaging Humans Infant Infant, Newborn 2007 4 24 9 0 2007 5 10 9 0 2007 4 24 9 0 ppublish 17449534 92/5/468 PMC2083715 Zh Vopr Neirokhir Im N N Burdenko. 1991 Jul-Aug;(4):16-9 1659075 Arch Dis Child. 2005 Sep;90(9):947-51 16113131 Arch Dis Child. 2005 Sep;90(9):952-5 16113132 Klin Padiatr. 1996 May-Jun;208(3):97-102 8676604

2007 Archives of Disease in Childhood

9819. Transvenous Treatment of Cranial Dural Arteriovenous Fistulas with Hydrogel Coated Coils Full Text available with Trip Pro

and future risk of intracranial bleeding and/or neurological deficit. Hydrogel coated coils (Hydro- Coil(R)) expand after contact with blood causing the coils to swell up to five to 11 times a standard 10-system bare platinum coil. Due to this property, HydroCoils could have an advantage over platinum coils in the transvenous approach to embolization of DAVFs. Ten patients with symptomatic cranial DAVF underwent a transvenous embolization using HydroCoils as the only embolic agent or in a combination (...) Transvenous Treatment of Cranial Dural Arteriovenous Fistulas with Hydrogel Coated Coils Intracranial dural arteriovenous fistulas (DAVF) with cortical venous reflux may become symptomatic due to venous congestion or intracranial hemorrhage. Venous congestion in the orbit can also occur resulting in proptosis, chemosis, double vision and progressive visual loss. The transvenous approach has been used for selective disconnection of the venous drainage to eliminate the venous congestion

2007 Interventional Neuroradiology

9820. Cranial bone defect healing is accelerated by mesenchymal stem cells induced by coadministration of bone morphogenetic protein-2 and basic fibroblast growth factor. (Abstract)

Cranial bone defect healing is accelerated by mesenchymal stem cells induced by coadministration of bone morphogenetic protein-2 and basic fibroblast growth factor. To facilitate bone healing in difficult circumstances, and to replace conventional therapeutic modalities, highly purified bone marrow-derived human mesenchymal stem cells (hMSCs) were investigated for induction of their osteogenic lineage upon provision of cytokine cues in vitro and in the cranial defect model in vivo. Alkaline (...) phosphatase-expressing cells were most frequently observed when the hMSCs were treated with 2.5 ng/ml of basic fibroblast growth factor (bFGF) and 50 ng/ml of bone morphogenetic protein (BMP)-2 for 4 days in culture after a 6-day incubation in osteogenic medium containing dexamethasone, ascorbic acid-2-phosphate, and beta-glycerophosphate. Four-millimeter full-thickness cranial defect wounds were made in male nude rats (F344/NJCl-rnu), whose deficit in the T cell compartment prevented T-cell-mediated

2004 Wound Repair and Regeneration

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