How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

9,987 results for

Cranial Nerve 10

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

9781. RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity. Full Text available with Trip Pro

RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity. Carpenter syndrome is a pleiotropic disorder with autosomal recessive inheritance, the cardinal features of which include craniosynostosis, polysyndactyly, obesity, and cardiac defects. Using homozygosity mapping, we found linkage to chromosome 6p12.1-q12 and, in 15 independent families, identified five different mutations (four truncating and one missense) in RAB23 (...) , which encodes a member of the RAB guanosine triphosphatase (GTPase) family of vesicle transport proteins and acts as a negative regulator of hedgehog (HH) signaling. In 10 patients, the disease was caused by homozygosity for the same nonsense mutation, L145X, that resides on a common haplotype, indicative of a founder effect in patients of northern European descent. Surprisingly, nonsense mutations of Rab23 in open brain mice cause recessive embryonic lethality with neural-tube defects, suggesting

2007 American Journal of Human Genetics

9782. New method of identifying the internal auditory canal as seen from the middle cranial fossa approach. (Abstract)

New method of identifying the internal auditory canal as seen from the middle cranial fossa approach. The middle cranial fossa approach allows one to remove acoustic tumors and preserve the facial nerve and hearing. However, there are no consistent landmarks on the surface of the temporal bone to identify the internal auditory canal. This study was designed to identify the internal auditory canal by use of external and internal references as seen during the middle cranial fossa approach.We (...) dissected 32 temporal bones using the middle cranial fossa approach and measured the distances from the posterior origin of the zygomatic arch to an imaginary coronal line between the foramen spinosum and the foramen ovale. We measured the angle between the lines drawn from the posterior origin of the zygomatic root to the foramen spinosum and from the foramen spinosum to the porus of the internal auditory canal.The distances were 14.7 mm and 22.9 mm, respectively, and the angle was roughly 90

2006 Rhinology and Laryngology

9783. Circumferential petrosectomy for petrous apicitis and cranial base osteomyelitis. (Abstract)

therapy (duration, 6-10 weeks) was administered after surgery, which resulted in the complete resolution of the disease and the associated symptoms in all five patients. No patient experienced hearing loss or facial nerve dysfunction as a result of the surgery within at least 1 year of follow-up in four of the five patients in this series.The circumferential petrosectomy is a potential treatment option when medical treatment fails in patients with petrositis or cranial base osteomyelitis. It permits (...) Circumferential petrosectomy for petrous apicitis and cranial base osteomyelitis. Petrous apicitis and cranial base osteomyelitis are life-threatening conditions. A surgical management may be necessary in cases that progress, in conditions that fail to improve with medical treatment, or in cases with impending complications. In this study, we describe a technique to remove the maximum amount of infected temporal bone while preserving the integrity of the peripheral auditory pathway and facial

2006 Otology and Neurotology

9784. Hypertrophic cranial pachymeningitis associated with middle ear inflammation. (Abstract)

imaging scans of the brain in all patients.Contrast-enhanced magnetic resonance imaging (MRI) of the brain, dural biopsy, and otomicroscopic examination.Thickening and abnormal enhancement of the dura mater on the MRI of the brain.All of the six patients had chronic inflammatory middle ear diseases. Three patients had otitis media with effusion, two had chronic otitis media, and one had postoperative otorrhea. The most common presentations of HCP were headache and cranial nerve palsies. Cranial Nerves (...) Hypertrophic cranial pachymeningitis associated with middle ear inflammation. To describe a series of patients with hypertrophic cranial pachymeningitis (HCP) associated with chronic middle ear inflammation.Retrospective case review.University Hospital.Six consecutive patients between the years 2000 and 2004 who had both middle ear disease and HCP (three men and three women; age range, 36-72 yr, mean age, 58.2 yr). The diagnosis of HCP was made by the use of contrast-enhanced magnetic resonance

2006 Otology and Neurotology

9785. Congenital unilateral multiple cranial neuropathy: an etiology shared with Mobius syndrome? (Abstract)

Congenital unilateral multiple cranial neuropathy: an etiology shared with Mobius syndrome? Mobius syndrome was originally described as bilateral 6th and 7th cranial nerve palsy and has since been expanded to include involvement of nearly all cranial nerves, limb deformities, orofacial anomalies and deficits in intellectual function. The etiology of Mobius syndrome remains elusive. Here we present a case with unilateral 5th, 7th, 9th, 10th and 12th cranial nerve palsy along with MRI evidence

2006 International Journal of Pediatric Otorhinolaryngology

9786. Penetrating orbital trauma by stiletto causing complex cranial neuropathies. Full Text available with Trip Pro

, and was treated with corticosteroids, however the globes escaped direct injury. Injuries to the IIIrd and VIth cranial nerves were also observed. Deep orbital injuries must be excluded in patients presenting with small eyelid wounds caused by sharp penetrating objects. (...) Penetrating orbital trauma by stiletto causing complex cranial neuropathies. Penetrating orbital injuries pose a serious threat to vision, ocular motility, and in some cases, life. Long, sharp stiletto objects may penetrate deeply, causing catastrophic damage to orbital structures, despite seemingly trivial entry wounds. The authors present two cases of penetrating orbital injuries by stiletto objects, both entering via small eyelid wounds. Traumatic optic neuropathy occurred in both cases

2006 Emergency Medicine Journal

9787. Epidemiology of blunt head injury victims undergoing ED cranial computed tomographic scanning. (Abstract)

of TBI, among patients selected for scanning, included the following: age below 10 years (relative risk [RR] = 1.44, 95% confidence interval [CI], 1.19-1.77); age above 65 years (RR = 1.59; 95% CI, 1.40-1.80), and male sex (RR = 1.27; 95% CI, 1.30-1.43).Among patients selected for cranial CT scanning after blunt head injury, men, patients younger than 10 years, and those older than 65 years have an increased likelihood of significant TBI. (...) Epidemiology of blunt head injury victims undergoing ED cranial computed tomographic scanning. We sought to describe the epidemiology of emergency department (ED) patients with blunt head injury undergoing cranial computed tomography (CT) scanning for the evaluation of possible traumatic brain injury (TBI).Prospective, multicenter, observational study of ED patients undergoing cranial CT after blunt head injury. Patient's date of birth, sex, and race/ethnicity were documented before CT scanning

2006 American Journal of Emergency Medicine

9788. Comparison of long-term neurocognitive outcomes in young children with acute lymphoblastic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate. (Abstract)

Comparison of long-term neurocognitive outcomes in young children with acute lymphoblastic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate. Cranial radiation therapy (CRT) is associated with neurocognitive morbidity in survivors of childhood acute lymphoblastic leukemia (ALL). For most patients, CRT has been replaced with intensified systemic and intrathecal chemotherapy, often including methotrexate (MTX). The impact of chemotherapy-only (...) protocols on neurocognitive outcomes is unclear, and the importance of systemic MTX dose has not been established.Seventy nine of 120 eligible children diagnosed with high-risk ALL between the ages of 1.0 and 4.9 years participated in this retrospective cohort study. All patients were treated on a uniform chemotherapy protocol with one of three modalities of CNS prophylaxis, depending on their treatment era. In addition to intrathecal therapy, CNS-directed therapy consisted of CRT (18 Gy in 10 fractions

2006 Journal of Clinical Oncology

9789. Pial arterial response to topical verapamil in acute closed cranial windows in rabbits. (Abstract)

the large proximal arteries. We tested our hypothesis in acute cranial windows implanted in 10 New Zealand White rabbits. After predrug measurements, we superfused 4 increasing concentrations of verapamil or nitroglycerin (10(-8), 10(-6), 10(-4), and 10(-3) M) in the cranial windows for 5 min each. The maximum increase in diameter was expressed as a percentage change from predrug diameters. There was a 30-min period of rest between the two drug challenges. Topical verapamil increased the arterial (...) Pial arterial response to topical verapamil in acute closed cranial windows in rabbits. We have previously observed that intraarterial verapamil increases cerebral blood flow, whereas nitric oxide donors, such as nitroglycerin, do not. Clinically, both verapamil and nitroglycerin dilate large cerebral arteries. Therefore, we hypothesized that topical verapamil would dilate both the large proximal and the small distal cerebral arteries, whereas nitroglycerin would preferentially dilate only

2005 Anesthesia and Analgesia

9790. Cranial irradiation and growth hormone neurosecretory dysfunction: a critical appraisal. Full Text available with Trip Pro

Cranial irradiation and growth hormone neurosecretory dysfunction: a critical appraisal. It has been suggested that radiation-induced GH neurosecretory dysfunction exists in children; however, the pathophysiology is poorly understood, and it is unknown if such a phenomenon exists in adult life.Twenty-four-hour spontaneous GH secretion was studied by 20-min sampling both in the fed state (n = 16; six women) and the last 24 h of 33-h fast (n = 10; three women) in adult cancer survivors of normal (...) GH status defined by two GH provocative tests, 13.1 +/- 1.6 (range, 3-28) yr after cranial irradiation (18-40 Gy) for nonpituitary brain tumors (n = 12) or leukemia (n = 4) in comparison with 30 (nine women) age- and body mass index-matched normal controls (fasting, 11 men and three women).Using previously published diagnostic thresholds, all patients had stimulated peak GH responses in the normal range to both the insulin tolerance test and the combined GHRH plus arginine stimulation test

2007 Journal of Clinical Endocrinology and Metabolism

9791. Absence of adrenocorticotropin (ACTH) neurosecretory dysfunction but increased cortisol concentrations and production rates in ACTH-replete adult cancer survivors after cranial irradiation for nonpituitary brain tumors. Full Text available with Trip Pro

neurosecretory dysfunction that might explain the excessive fatigue suffered by some cancer survivors.Cortisol profiling at 20-min intervals over 24 h during the fed state was undertaken in 34 patients (10 females), aged 17-53.7 yr (median, 21.5 yr), 2-29 yr (median, 11.5 yr) after receiving conventional cranial irradiation for nonpituitary brain tumors or leukemia (n = 5) and in 33 age-, gender-, and body mass index-matched normal controls, of whom 23 patients and 17 controls were also profiled in the last (...) Absence of adrenocorticotropin (ACTH) neurosecretory dysfunction but increased cortisol concentrations and production rates in ACTH-replete adult cancer survivors after cranial irradiation for nonpituitary brain tumors. For the first time, physiological cortisol secretion has been studied in ACTH-replete adult cancer survivors to explore any discrepancy between stimulated (during insulin-induced hypoglycemia) and spontaneous cortisol secretion and, in particular, the possible existence of ACTH

2005 Journal of Clinical Endocrinology and Metabolism

9792. Cranial bone defect healing is accelerated by mesenchymal stem cells induced by coadministration of bone morphogenetic protein-2 and basic fibroblast growth factor. (Abstract)

Cranial bone defect healing is accelerated by mesenchymal stem cells induced by coadministration of bone morphogenetic protein-2 and basic fibroblast growth factor. To facilitate bone healing in difficult circumstances, and to replace conventional therapeutic modalities, highly purified bone marrow-derived human mesenchymal stem cells (hMSCs) were investigated for induction of their osteogenic lineage upon provision of cytokine cues in vitro and in the cranial defect model in vivo. Alkaline (...) phosphatase-expressing cells were most frequently observed when the hMSCs were treated with 2.5 ng/ml of basic fibroblast growth factor (bFGF) and 50 ng/ml of bone morphogenetic protein (BMP)-2 for 4 days in culture after a 6-day incubation in osteogenic medium containing dexamethasone, ascorbic acid-2-phosphate, and beta-glycerophosphate. Four-millimeter full-thickness cranial defect wounds were made in male nude rats (F344/NJCl-rnu), whose deficit in the T cell compartment prevented T-cell-mediated

2004 Wound Repair and Regeneration

9793. Orbital varices, cranial defects, and encephaloceles: an unrecognized association. (Abstract)

anomalies.All available orbital imaging for patients with orbital venous anomalies was examined. For those with defects of the cranial base, the radiologic characteristics were noted and the clinical details were reviewed.The presence and type of orbital roof or medial wall defects and associated nasal or other cranial anomalies.Imaging was adequate for review in 222 of 310 patients (72%), and anomalies of the neighboring cranium or cerebral structure were found in 10 of 222 patients (4.5%). In the group (...) with cranial anomalies, the proportion of men (7/10; 70%) did not significantly differ from that in the group with varices but without cranial anomalies (93/212; 44%; P = 0.19, Fisher exact test). Orbital varices were associated with 3 types of cranial anomaly: major midline encephaloceles (type I anomaly; 4 cases), large superomedial defects of the orbital wall (type II; 3 cases), or defects of the greater wing of the sphenoid (type III; 3 cases).Clinicians should be aware of the possibility

2004 Ophthalmology

9794. Assessment of the cranial involvement pattern of giant cell arteritis with 3T magnetic resonance imaging. (Abstract)

thickness and lumen diameter of the major cranial arteries on both sides of the head. In all cases, MRI results were compared with findings of clinical examination and laboratory tests. In addition, temporal artery biopsy specimens from 10 patients were examined by histology.MRI sharply revealed all of the major superficial cranial arteries, allowing for an evaluation of their lumen and vessel wall. Nine of the 21 patients were diagnosed as having GCA according to the criteria of the American College (...) Assessment of the cranial involvement pattern of giant cell arteritis with 3T magnetic resonance imaging. To noninvasively determine the involvement pattern of the cranial arteries in giant cell arteritis (GCA), with high-resolution magnetic resonance imaging (MRI).The superficial cranial arteries of 21 patients with suspected GCA were examined using a 3T high-field MRI scanner. Postcontrast T1-weighted spin-echo images were acquired with submillimeter spatial resolution, to assess mural

2005 Arthritis and Rheumatism

9795. Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three patients and review of the literature. (Abstract)

Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three patients and review of the literature. Intracranial malignancies (primary and metastatic) are often complicated by seizure activity. Phenytoin (Dilantin) is typically employed as prophylactic anticonvulsant in this setting. Uncommonly, erythema multiforme (EM) can develop in such patients at the port site during or soon after cranial radiation and can rapidly progress to EM major. Herein, in addition (...) to a comprehensive literature review of this entity, three additional patients are presented. The acronym 'EMPACT' is suggested (E: erythema; M: multiforme; associated with P: phenytoin; A: and; C: cranial, radiation; T: therapy) to best describe this disorder.An extensive review of the English medical literature through the National Library of Medicine (PUBMED) was performed to identify patients who had received or continued to receive radiation therapy while on phenytoin. A total of 24 patients were identified

2004 International Journal of Dermatology

9796. Cranial Electrotherapy Stimulation in Burned Patients

and anxiety. Mean Visual Analogue Scale of Pain (VAS-P) Before and After Cranial Electrotherapy Stimulation (CES). [ Time Frame: Blinded Period, Unblinded Period ] Subjects were asked to evaluate their pain intensity before and after each daily CES or sham treatment. Responses were scored on a scale ranging from 0 (indicating no pain) to 10 (worst possible pain). Mean Visual Analogue Scale of Anxiety (VAS-A) Before and After Cranial Electrotherapy Stimulation (CES). [ Time Frame: Blinded Period, Unblinded (...) Cranial Electrotherapy Stimulation in Burned Patients Cranial Electrotherapy Stimulation in Burned Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cranial Electrotherapy Stimulation in Burned

2007 Clinical Trials

9797. Prophylactic Cranial Irradiation (PCI) for Small Cell Carcinoma of the Urothelium

Prophylactic Cranial Irradiation (PCI) for Small Cell Carcinoma of the Urothelium Prophylactic Cranial Irradiation (PCI) for Small Cell Carcinoma of the Urothelium - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Prophylactic Cranial Irradiation (PCI) for Small Cell Carcinoma of the Urothelium The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00756639 Recruitment Status : Active, not recruiting First Posted : September 22, 2008 Last Update Posted : April 19, 2018 Sponsor: M.D. Anderson Cancer Center

2008 Clinical Trials

9798. Repetitive Trans-cranial Magnetic Stimulation of the Motor Cortex in Fibromyalgia: A Study Evaluating the Clinical Efficiency and the Metabolic Correlate in 18FDG-PET

Repetitive Trans-cranial Magnetic Stimulation of the Motor Cortex in Fibromyalgia: A Study Evaluating the Clinical Efficiency and the Metabolic Correlate in 18FDG-PET Repetitive Trans-cranial Magnetic Stimulation of the Motor Cortex in Fibromyalgia: A Study Evaluating the Clinical Efficiency and the Metabolic Correlate in 18FDG-PET - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms (...) x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Repetitive Trans-cranial Magnetic Stimulation of the Motor Cortex in Fibromyalgia: A Study Evaluating the Clinical Efficiency and the Metabolic Correlate in 18FDG-PET The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been

2008 Clinical Trials

9799. Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery

. Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00438087 Recruitment Status : Completed First Posted : February 21, 2007 Last Update Posted : July 10, 2012 Sponsor: Assistance Publique - Hôpitaux de Paris Information provided (...) by (Responsible Party): Assistance Publique - Hôpitaux de Paris Study Details Study Description Go to Brief Summary: Facial palsy after surgical removal of cranial base tumors adherent to the nerve can partly be explained by inflammation. Condition or disease Intervention/treatment Phase Facial Palsy Drug: methylprednisolone Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 313 participants Allocation: Randomized Intervention Model

2007 Clinical Trials

9800. Canine cranial cruciate ligament rupture in profile: 2002–2007 Full Text available with Trip Pro

Canine cranial cruciate ligament rupture in profile: 2002–2007 18309752 2008 03 24 2018 11 13 0008-5286 49 2 2008 Feb The Canadian veterinary journal = La revue veterinaire canadienne Can. Vet. J. Canine cranial cruciate ligament rupture in profile: 2002-2007. 193-4 Harasen Greg G Animal Clinic of Regina, 1800 Garnet Street, Regina, Saskatchewan S4T 2Z2. eng Journal Article Canada Can Vet J 0004653 0008-5286 IM Age Factors Animals Anterior Cruciate Ligament Injuries Breeding Canada Dog (...) Diseases epidemiology surgery Dogs Joint Diseases epidemiology surgery veterinary Osteotomy methods veterinary Rupture surgery veterinary Sex Factors Treatment Outcome 2008 3 4 9 0 2008 3 25 9 0 2008 3 4 9 0 ppublish 18309752 PMC2216436 Aust Vet J. 1995 Aug;72(8):281-5 8579557 J Am Vet Med Assoc. 2006 Jan 1;228(1):61-4 16426167 Vet Surg. 1998 Nov-Dec;27(6):533-9 9845216 Can Vet J. 2003 Oct;44(10):845-6 14601687 Can Vet J. 1995 Apr;36(4):250-1 7600520 J Am Vet Med Assoc. 2003 Jan 15;222(2):184-93

2008 The Canadian Veterinary Journal

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>