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Cranial Nerve 10

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241. Prophylactic Cranial Irradiation Following Surgical Resection of Early-Stage Small-Cell Lung Cancer: A Review of the Literature Full Text available with Trip Pro

Prophylactic Cranial Irradiation Following Surgical Resection of Early-Stage Small-Cell Lung Cancer: A Review of the Literature With increasing use of low-dose screening CT scans, the diagnosis of early-stage small-cell lung cancer (SCLC) without evidence of mediastinal nodal or distant metastasis is likely to become more common, but the role of adjuvant therapies such as prophylactic cranial irradiation (PCI) are not well understood in this population. We performed a review of the literature (...) pertaining to the impact of PCI in patients who underwent surgical resection of early-stage SCLC. Four studies were identified that were pertinent including three single-institution retrospective analyses and a National Cancer Database analysis. Based upon these studies, we estimate the rate of brain metastases to be 10-15% for Stage I and 15-25% for Stage II disease without PCI. However, the impact of PCI on the development of brain metastases and its ultimate impact on overall survival were

2017 Frontiers in oncology

242. Health-related quality of life of cranial WHO grade I meningioma patients: are current questionnaires relevant? Full Text available with Trip Pro

Health-related quality of life of cranial WHO grade I meningioma patients: are current questionnaires relevant? The clinical relevance of Health-Related Quality of Life (HRQoL) in meningioma patients has been increasingly acknowledged in recent years. Various questionnaires have been used. However, almost none of these questionnaires has been particularly developed for and/or validated in this patient group. Therefore, the aim of this study was to assess the relevance and comprehensiveness (...) relevant), (2) assess the ten most important issues, and (3) identify new relevant HRQoL issues.Fourteen different questionnaires were found in the literature, comprising 140 unique issues. Interviews were conducted with 20 patients (median age 57, 71% female) and 10 HCPs (4 neurosurgeons, 2 neurologists, 2 radiotherapists, 1 rehabilitation specialist, 1 neuropsychologist; median experience 13 years). Meningioma patients rated 17-80% of the issues in each of the questionnaires as relevant, HCPs 90-100

2017 Acta neurochirurgica

243. Constitutively active Notch1 converts cranial neural crest-derived frontonasal mesenchyme to perivascular cells in vivo Full Text available with Trip Pro

Constitutively active Notch1 converts cranial neural crest-derived frontonasal mesenchyme to perivascular cells in vivo Perivascular/mural cells originate from either the mesoderm or the cranial neural crest. Regardless of their origin, Notch signalling is necessary for their formation. Furthermore, in both chicken and mouse, constitutive Notch1 activation (via expression of the Notch1 intracellular domain) is sufficient in vivo to convert trunk mesoderm-derived somite cells to perivascular (...) cells, at the expense of skeletal muscle. In experiments originally designed to investigate the effect of premature Notch1 activation on the development of neural crest-derived olfactory ensheathing glial cells (OECs), we used in ovo electroporation to insert a tetracycline-inducible NotchΔE construct (encoding a constitutively active mutant of mouse Notch1) into the genome of chicken cranial neural crest cell precursors, and activated NotchΔE expression by doxycycline injection at embryonic day 4

2017 Biology open

244. The spatial accuracy of two frameless, linear accelerator‐based systems for single‐isocenter, multitarget cranial radiosurgery Full Text available with Trip Pro

The spatial accuracy of two frameless, linear accelerator‐based systems for single‐isocenter, multitarget cranial radiosurgery Single-isocenter, multitarget cranial stereotactic radiosurgery (SRS) is more efficient than using an isocenter for each target, but spatial positioning uncertainties can be magnified at locations away from the isocenter. This study reports on the spatial accuracy of two frameless, linac-based SRS systems for multitarget, single-isocenter SRS as a function (...) to about 7-8 cm from the isocenter. For distances 10 cm or more, the CBCT-based alignment remained within 1.1 mm while the ExacTrac-based alignment differed by up to 2.2 mm.© 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

2017 Journal of Applied Clinical Medical Physics

245. Clinical Features, Imaging Characteristics, and Long‐term Outcome of Dogs with Cranial Meningocele or Meningoencephalocele Full Text available with Trip Pro

Clinical Features, Imaging Characteristics, and Long‐term Outcome of Dogs with Cranial Meningocele or Meningoencephalocele The term meningoencephalocele (MEC) describes a herniation of cerebral tissue and meninges through a defect in the cranium, whereas a meningocele (MC) is a herniation of the meninges alone.To describe the clinical features, magnetic resonance imaging (MRI) characteristics, and outcomes of dogs with cranial MC and MEC.Twenty-two client-owned dogs diagnosed with cranial MC (...) enhancement of the protruded tissue in 77% of the cases. Porencephaly was seen in all cases with parietal MC. Cerebrospinal fluid (CSF) analysis identified mild abnormalities in 4 of 11 cases. Surgery was not performed in any affected dog. Seventeen patients were treated medically, and seizures were adequately controlled with anti-epileptic drugs in 10 dogs. Dogs with intranasal MEC and mild neurologic signs had a fair prognosis with medical treatment.Although uncommon, MC and MEC should be considered

2017 Journal of Veterinary Internal Medicine

246. Morphological and Morphometric Analysis of Hypoglossal Canal in North Indian Dry Skulls and It’s Significance in Cranial Base Surgeries Full Text available with Trip Pro

Morphological and Morphometric Analysis of Hypoglossal Canal in North Indian Dry Skulls and It’s Significance in Cranial Base Surgeries Hypoglossal Canal (HC) is a paired bony passage which is situated above the Occipital Condyle (OC) and transmits hypoglossal nerve and blood vessels. Studies on the osteotic variations of HC has been a field of considerable interest to research workers especially because of its clinical, radiological and surgical significance.The aim of the present study

2017 Journal of clinical and diagnostic research : JCDR

247. Annexin A6 controls neuronal membrane dynamics throughout chick cranial sensory gangliogenesis Full Text available with Trip Pro

Annexin A6 controls neuronal membrane dynamics throughout chick cranial sensory gangliogenesis Cranial sensory ganglia are components of the peripheral nervous system that possess a significant somatosensory role and include neurons within the trigeminal and epibranchial nerve bundles. Although it is well established that these ganglia arise from interactions between neural crest and neurogenic placode cells, the molecular basis of ganglia assembly is still poorly understood. Members (...) of the Annexin protein superfamily play key roles in sensory nervous system development throughout metazoans. Annexin A6 is expressed in chick trigeminal and epibranchial placode cell-derived neuroblasts and neurons, but its function in cranial ganglia formation has not been elucidated. To this end, we interrogated the role of Annexin A6 using gene perturbation studies in the chick embryo. Our data reveal that placode cell-derived neuroblasts with reduced Annexin A6 levels ingress and migrate normally

2017 Developmental biology

248. Carbon dioxide-mediated vasomotion of extra-cranial cerebral arteries in humans: a role for prostaglandins? Full Text available with Trip Pro

Carbon dioxide-mediated vasomotion of extra-cranial cerebral arteries in humans: a role for prostaglandins? Cerebral blood flow increases during hypercapnia and decreases during hypocapnia; it is unknown if vasomotion of the internal carotid artery is implicated in these responses. Indomethacin, a non-selective cyclooxygenase inhibitor (used to inhibit prostaglandin synthesis), has a unique ability to blunt cerebrovascular carbon dioxide reactivity, while other cyclooxygenase inhibitors have (...) no effect. We show significant dilatation and constriction of the internal carotid artery during hypercapnia and hypocapnia, respectively. Indomethacin, but not ketorolac or naproxen, reduced the dilatatory response of the internal carotid artery to hypercapnia The differential effect of indomethacin compared to ketorolac and naproxen suggests that indomethacin inhibits vasomotion of the internal carotid artery independent of prostaglandin synthesis inhibition.Extra-cranial cerebral blood vessels

2017 The Journal of physiology Controlled trial quality: uncertain

249. Unusual cranial infection caused by Citrobacter Koseri. (Abstract)

Unusual cranial infection caused by Citrobacter Koseri. A 60-year-old female had a frontal bone intraosseous meningioma resected 10 years previously. On follow up CT head, an enlarging intraosseous frontal bone lesion was noted. This was thought to be a recurrent frontal meningioma. Intraooperatively, she was found to have an abscess deep to the cranioplasty.

2017 British Journal of Neurosurgery

250. Intra cranial granulomatous disease in common variable immunodeficiency: Case series and review of the literature. (Abstract)

Intra cranial granulomatous disease in common variable immunodeficiency: Case series and review of the literature. Common variable immunodeficiency (CVID) is typically characterized by hypogammaglobulinemia and often but not always recurrent infections. Paradoxically, 8-22% of patients with CVID develop granulomatous disease. Granulomata have been described in many organs including the lungs, skin, liver, spleen, kidneys, eyes, lymph nodes, and intestines. Data about central nervous system (CNS (...) ; mean age when the CNS disease was diagnosed was 21.5 years. 68.4% of the patients (13/19) had granulomas involving ≥2 organs including the central nervous system, 31.6% (6/19) had CNS granulomas only. Associated granulomatous diseases occurred in lungs (72.7%), lymph nodes (27.2%), spleen (27.2%), eyes (18.1%), liver (18.1%), parotid glands (9%), and skin (9%). Fifty-three percent (10/19) of the patients had documented recurrent infections, all of them being upper respiratory tract infections. CNS

2017 Seminars in arthritis and rheumatism

251. A case study of Ramsay Hunt Syndrome in conjunction with cranial polyneuritis. Full Text available with Trip Pro

A case study of Ramsay Hunt Syndrome in conjunction with cranial polyneuritis. Ramsay Hunt syndrome in conjunction with cranial polyneuritis is not extensively documented, and is very easily misdiagnosed.A case of a 53-year-old male with Ramsay Hunt syndrome in conjunction with cranial polyneuritis is presented with early symptoms of vertigo, cephalalgia, and facial palsy, followed by zoster oticus 10 days later.Diagnosis was challenging as this condition presents with multiple neuropathies (...) , and attempting to diagnose based on clinical symptoms was often misleading. Polymerase chain reaction can be used to test for presence of the virus in the cerebrospinal fluid, followed by targeted drug therapy.Acupuncture, in conjunction with fire cupping, bloodletting around the afflicted region on the face, as well as oral consumption of herbal medicine and vitamins for nerve nourishment was given to treat this disease.Due to misdiagnosis resulting in delayed treatment, peripheral facial paralysis was left

2017 Medicine

252. Matched increases in cerebral artery shear stress, irrespective of stimulus, induce similar changes in extra-cranial arterial diameter in humans. Full Text available with Trip Pro

of the large extra-cranial arteries. Participants ( n = 10) participated in three 30-min experimental interventions, each separated by ≥48 h: (1) mild-hypercapnia (FICO2:∼0.045); (2) submaximal cycling (EX; 60%HRreserve); or (3) resting (time-matched control, CTRL). Blood flow, diameter, and shear rate were assessed (via Duplex ultrasound) in the internal carotid and vertebral arteries (ICA, VA) at baseline, during and following the interventions. Hypercapnia and EX produced similar elevations in blood (...) Matched increases in cerebral artery shear stress, irrespective of stimulus, induce similar changes in extra-cranial arterial diameter in humans. The mechanistic role of arterial shear stress in the regulation of cerebrovascular responses to physiological stimuli (exercise and hypercapnia) is poorly understood. We hypothesised that, if shear stress is a key regulator of arterial dilation, then matched increases in shear, induced by distinct physiological stimuli, would trigger similar dilation

2017 Journal of Cerebral Blood Flow and Metabolism

253. Gustatory lid retraction: an unusual congenital cranial dysinnervation disorder. (Abstract)

Gustatory lid retraction: an unusual congenital cranial dysinnervation disorder. Congenital cranial dysinnervation disorders are developmental abnormalities of cranial nerves that often include abnormal synkinesis. Among the most common ophthalmic congenital cranial dysinnervation disorders are Duane retraction syndrome and the Marcus-Gunn jaw-winking phenomenon. This report documents gustatory lid retraction as an unusual congenital cranial dysinnervation.Copyright © 2017 American Association

2017 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

254. Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial. (Abstract)

to observation was 0·011%, resulting in early termination of the study because of futility. In the final analysis, median overall survival was 11·6 months (95% CI 9·5-13·3) in the prophylactic cranial irradiation group and 13·7 months (10·2-16·4) in the observation group (hazard ratio 1·27, 95% CI 0·96-1·68; p=0·094). The most frequent grade 3 or worse adverse events at 3 months were anorexia (six [6%] of 106 in the prophylactic cranial irradiation group vs two [2%] of 111 in the observation group), malaise (...) Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial. Results from a previous phase 3 study suggested that prophylactic cranial irradiation reduces the incidence of symptomatic brain metastases and prolongs overall survival compared with no prophylactic cranial irradiation in patients with extensive-disease small-cell lung cancer. However, because of the absence of brain imaging before

2017 Lancet Oncology Controlled trial quality: predicted high

255. Cranial Electrotherapy Stimulation for the Management of Depression, Anxiety, Sleep Disturbance, and Pain in Patients with Advanced Cancer: A preliminary study. Full Text available with Trip Pro

Cranial Electrotherapy Stimulation for the Management of Depression, Anxiety, Sleep Disturbance, and Pain in Patients with Advanced Cancer: A preliminary study. Cranial electrotherapy stimulation (CES) is a safe modulation of brain activity for treating depression, anxiety, insomnia, and pain. However, there are no published studies in patients with advanced cancer (ACPs).The aim of the study was to determine the feasibility and preliminary efficacy of a four-week CES intervention on depression (...) , anxiety, sleep disturbance, and pain scores. Concurrent salivary biomarker studies were conducted.In this one group open label pre- and post-intervention study with a four-week CES intervention, ACPs with one or more of four moderate intensity (≥3/10) Edmonton Symptom Assessment Scale (ESAS) symptoms (depression, anxiety, sleep disturbance, and pain) were eligible. Adherence (0%-100%), satisfaction rates (0-10), and safety were assessed. ESAS, Hospital Anxiety and Depression Scale (HADS), Pittsburgh

2017 Journal of pain and symptom management

256. [Influence of cranial radiotherapy on outcome in children with acute lymphoblastic leukemia treated with contemporary therapy]. (Abstract)

[Influence of cranial radiotherapy on outcome in children with acute lymphoblastic leukemia treated with contemporary therapy]. 27091457 2017 01 30 2018 11 13 1439-099X 192 5 2016 May Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] Strahlenther Onkol [Influence of cranial radiotherapy on outcome in children with acute lymphoblastic leukemia treated with contemporary therapy]. 352-3 10.1007/s00066-016-0965-0 Sauer Martin G MG Klinik für Pädiatrische (...) administration & dosage Brain Neoplasms drug therapy epidemiology radiotherapy Child Child, Preschool Cranial Irradiation methods statistics & numerical data Humans Methotrexate administration & dosage Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy epidemiology radiotherapy Randomized Controlled Trials as Topic Secondary Prevention methods statistics & numerical data Treatment Outcome 2016 4 20 6 0 2016 4 20 6 0 2017 1 31 6 0 ppublish 27091457 10.1007/s00066-016-0965-0 10.1007/s00066-016-0965-0

2017 Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]

257. Growth changes in the anterior and middle cranial bases assessed with cone-beam computed tomography in adolescents. (Abstract)

landmarks.Cone-beam computed tomography images of 10 dry skulls were used to identify useful landmarks from different areas of the anterior and middle cranial bases based on their reliability and accuracy. These selected landmarks were identified in the images of an already available sample of adolescents (n = 60) taken at 2 time points (19 months apart) to assess dimensional changes with growth.The majority of the proposed 3-dimensional landmarks with the exception of the lesser wing of the sphenoid showed (...) Growth changes in the anterior and middle cranial bases assessed with cone-beam computed tomography in adolescents. Initially, cone-beam computed tomography images from dry skulls were used to 3 dimensionally evaluate intrarater and interrater reliabilities and accuracy of selected 3-dimensional landmarks located in the anterior and middle cranial bases. Thereafter, dimensional changes of the anterior and middle cranial bases with growth were evaluated by using the previously selected

2017 American journal of orthodontics and dentofacial orthopedics

258. Cranial Laser Reflex Technique for Hamstring Function

treatment session, the participants completed a de-blinding questionnaire administrated by the assessor providing a dichotomous 'yes' or 'no' answer as to whether active treatment was received. This response was followed by a second question regarding how certain they were that active treatment was received on a 0-10 numeric rating scale (NRS), where 0 represents absolutely uncertain and 10 represents absolutely certain. Primary Purpose: Treatment Official Title: The Effects of Cranial Laser Reflex (...) Cranial Laser Reflex Technique for Hamstring Function Cranial Laser Reflex Technique for Hamstring Function - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cranial Laser Reflex Technique for Hamstring

2017 Clinical Trials

259. Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies

strabismus and eyelid movement disorders for over 10 years and the lab's interests have expanded to include Congenital Cranial Dysinnervation Disorders (CCDDs) which are neurological disorders affecting one or more of the 12 cranial nerves. Cranial nerves control bodily functions such as movement of the eyes, transmission of visual information, smell, facial sensation, facial expression, blinking, hearing, balance, taste, chewing and swallowing. Based on genetic studies on individuals with eye movement (...) : January 2022 Resource links provided by the National Library of Medicine related topics: resources: Groups and Cohorts Go to Outcome Measures Go to Primary Outcome Measures : Identifying and characterizing genes important in normal development and function of the ocular motility system, cranial nerves and brainstem and associated with congenital cranial dysinnervation disorders and related anomalies. [ Time Frame: Ongoing ] This is an observational, descriptive study with no interventions geared

2017 Clinical Trials

260. Prospective Study of Hippocampal-Sparing Prophylactic Cranial Irradiation in Limited-Stage Small Cell Lung Cancer. (Abstract)

Prospective Study of Hippocampal-Sparing Prophylactic Cranial Irradiation in Limited-Stage Small Cell Lung Cancer. To prospectively evaluate cognitive function and intracranial failure patterns after hippocampal-sparing prophylactic cranial irradiation (PCI) for limited-stage small cell lung cancer (SCLC).Adults with limited-stage SCLC, achieving a complete response to chemoradiotherapy and no brain metastases, were eligible. Patients received PCI 25 Gy/10 fractions, with a mean hippocampal

2017 Biology and Physics

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