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Cranial Nerve 10

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221. Annexin A6 controls neuronal membrane dynamics throughout chick cranial sensory gangliogenesis Full Text available with Trip Pro

Annexin A6 controls neuronal membrane dynamics throughout chick cranial sensory gangliogenesis Cranial sensory ganglia are components of the peripheral nervous system that possess a significant somatosensory role and include neurons within the trigeminal and epibranchial nerve bundles. Although it is well established that these ganglia arise from interactions between neural crest and neurogenic placode cells, the molecular basis of ganglia assembly is still poorly understood. Members (...) of the Annexin protein superfamily play key roles in sensory nervous system development throughout metazoans. Annexin A6 is expressed in chick trigeminal and epibranchial placode cell-derived neuroblasts and neurons, but its function in cranial ganglia formation has not been elucidated. To this end, we interrogated the role of Annexin A6 using gene perturbation studies in the chick embryo. Our data reveal that placode cell-derived neuroblasts with reduced Annexin A6 levels ingress and migrate normally

2017 Developmental biology

222. Comments on “Neuromuscular Ultrasonography of Cranial Nerves” Full Text available with Trip Pro

Comments on “Neuromuscular Ultrasonography of Cranial Nerves” 28406588 2019 01 11 1738-6586 13 2 2017 04 Journal of clinical neurology (Seoul, Korea) J Clin Neurol Comments on "Neuromuscular Ultrasonography of Cranial Nerves". 212-213 10.3988/jcn.2017.13.2.212 Tenuta Maurizio M Azienda Ospedaliera Universitaria OO.RR. San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy. De Bernardo Maddalena M Azienda Ospedaliera Universitaria OO.RR. San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy

2017 Journal of clinical neurology (Seoul, Korea)

223. Re: Comments on “Neuromuscular Ultrasonography of Cranial Nerves”: The Authors Respond Full Text available with Trip Pro

Re: Comments on “Neuromuscular Ultrasonography of Cranial Nerves”: The Authors Respond 28406589 2018 11 13 1738-6586 13 2 2017 04 Journal of clinical neurology (Seoul, Korea) J Clin Neurol Re: Comments on "Neuromuscular Ultrasonography of Cranial Nerves": The Authors Respond. 214 10.3988/jcn.2017.13.2.214 Tawfik Eman A EA Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Walker Francis O FO Department of Neurology, Medical Center

2017 Journal of clinical neurology (Seoul, Korea)

224. The p75 neurotrophin receptor regulates cranial irradiation-induced hippocampus-dependent cognitive dysfunction Full Text available with Trip Pro

regulation of spine density, which are associated with various neurological disorders. In this study, male Sprague-Dawley (SD) rats received 10 Gy cranial irradiation. Then, we evaluated the expression of p75NTR in the hippocampus after cranial irradiation and explored its potential role in radiation-induced synaptic dysfunction and memory deficits. We found that the expression of p75NTR was significantly increased in the irradiated rat hippocampus. Knockdown of p75NTR by intrahippocampal infusion (...) The p75 neurotrophin receptor regulates cranial irradiation-induced hippocampus-dependent cognitive dysfunction Cognitive deficits, characterized by progressive problems with hippocampus-dependent learning, memory and spatial processing, are the most serious complication of cranial irradiation. However, the underlying mechanisms remain obscure. The p75 neurotrophin receptor (p75NTR) is involved in a diverse arrays of cellular responses, including neurite outgrowth, neurogenesis, and negative

2017 Oncotarget

225. A Rare Presentation of Cranial Polyneuropathy Without Rash Caused by Varicella Zoster Virus Full Text available with Trip Pro

A Rare Presentation of Cranial Polyneuropathy Without Rash Caused by Varicella Zoster Virus Varicella Zoster Virus (VZV) is associated with many disorders of the central and peripheral nervous systems including neuralgia, meningitis, meningoencephalitis, cerebellitis, vasculopathy, myelopathy, Ramsay-Hunt syndrome, and polyneuritis cranialis. Cranial nerves V, VI, VII, VIII, IX, X, XI, and/or XII may be affected. The neurological disorders caused by VZV usually present with rash, but may rarely (...) present without rash.We herein present a case of polyneuritis cranialis without rash caused by VZV affecting cranial nerves VII, VIII, IX, and X. After excluding other causes of the condition, we diagnosed VZV infection based on VZV DNA in the CSF and an elevated anti-VZV IgG level in serum. The patient responded well to antiviral therapy.VZV infection should be kept in mind during the differential diagnosis of polyneuritis cranialis; it is important to note that VZV re-activation may occur without

2017 Medical Archives

226. Perihippocampal metastasis following hippocampus-avoiding prophylactic cranial irradiation for small cell lung cancer: a case report Full Text available with Trip Pro

Perihippocampal metastasis following hippocampus-avoiding prophylactic cranial irradiation for small cell lung cancer: a case report Prophylactic cranial irradiation (PCI) lowers the risk of brain metastasis (BM) and increases survival in small cell lung cancer (SCLC) patients, but it also entails a risk of neurocognitive dysfunction (NCD). One strategy to mitigate this neurotoxicity is hippocampus-avoiding (HA) whole-brain radiation therapy, as the hippocampus is mainly responsible (...) for radiation-related NCD and hippocampal or perihippocampal metastases are rare. A few prospective clinical trials have demonstrated a reduction in NCD following HA whole-brain radiation therapy. The 59-year-old male patient described in this report had limited-stage SCLC and a complete response to thoracic chemoradiotherapy. Seven months after receiving HA-PCI of 25 Gy in 10 fractions using intensity-modulated radiation therapy, a 36 mm solitary metastasis was detected in the right perihippocampal region

2017 OncoTargets and therapy

227. Diagnostic Challenge: Sequential Unilateral Cranial Neuropathies Due to Perineural Spread of Carcinoma Full Text available with Trip Pro

Diagnostic Challenge: Sequential Unilateral Cranial Neuropathies Due to Perineural Spread of Carcinoma An 86-year old man developed sequential dysfunction of trigeminal (V1), facial, abducens, trigeminal (v2), oculomotor, and hypoglossal cranial nerves on the right over 20 months. Magnetic resonance imaging (MRI) showed a lesion in the right cavernous sinus. Although there was clinical suspicion that this was related to perineural spread of an extracranial tumour, a primary lesion

2017 Neuro-Ophthalmology

228. Complete Cranial Iliac Osteotomy to Approach the Lumbosacral Foramen Full Text available with Trip Pro

Complete Cranial Iliac Osteotomy to Approach the Lumbosacral Foramen An approach using a complete cranial iliac osteotomy (CCIO) to access the lumbosacral (LS) foramen in dogs from lateral was developed using cadavers and applied in a clinical patient with degenerative lumbosacral stenosis (DLSS). The foraminal enlargement in the cadavers and the patient was documented on postoperative CT scans. The preoperative CT scan of the patient showed moderate cranial telescoping of the sacral roof (...) and a moderate central disk protrusion, leading to moderate to severe compression of the cauda equina. In addition, there was lateral spondylosis with consequential stenosis of the right LS foramen. The right L7 nerve had lost its fat attenuation and appeared thickened. After a routine L7S1 dorsal laminectomy with a partial discectomy, a CCIO was performed, providing good access to the LS foramen and the adhesions around the proximal L7 nerve caudoventral to the foramen. The osteotomy was stabilized

2017 Frontiers in veterinary science

229. A congenital cranial dysinnervation disorder: Möbius’ syndrome Full Text available with Trip Pro

A congenital cranial dysinnervation disorder: Möbius’ syndrome Möbius' syndrome, also known as Möbius' sequence, is a nonprogressive cranial dysinnervation disorder characterized by congenital facial and abducens nerve paralysis. Here, we report a 5-day-old girl who was conceived after in vitro fertilization with poor suck and facial paralysis. She had bilaterally ptosis and lateral gaze limitation, left-sided deviation of the tongue, dysmorphic face, hypoplastic fingers and finger nails (...) on the left hand, and was diagnosed as having Möbius' syndrome. Involvement of other cranial nerves such as three, four, five, nine, 9 and 12, and limb malformations may accompany this syndrome. However, several factors have been proposed for the etiology, some rare cases have also been reported with artificial reproductive technologies. Feeding difficulties and aspiration are the main problems encountered in infancy. The other cranial nerves should be examined further in newborns who present

2017 Turkish Archives of Pediatrics/Türk Pediatri Arşivi

230. Multiple Primary Recurrent Basaliomas (mPR-BCCs) of the Scalp with Cranial Bone Invasion Full Text available with Trip Pro

surgery (MMS), with MMS being the gold standard for the definitive treatment of BCC. Improper removal or electrocautery (as in our case) of the several aggressive forms of BCC seems to be a particular problem, and not only for dermatologic surgeons. The risk of subsequent invasion and destruction of the cranium, underlying dura, and cranial nerves by basal cell carcinoma (BCC) is extremely low, with an estimated incidence of 0.03%, but is a potential complication over time. Computed tomography (...) Multiple Primary Recurrent Basaliomas (mPR-BCCs) of the Scalp with Cranial Bone Invasion We present a 68-year-old patient with multiple primary infiltrative BCCs in the scalp area, initially treated 14 years ago with superficial contact X-ray therapy, end dose 60 greys, followed by electrocautery (x2) several years later. He presented in the dermatologic policlinic for diagnosis and therapy of two additional, newly-formed pigmented lesions, and because of an uncomfortable, itchy, burning

2017 Open access Macedonian journal of medical sciences

231. Health-related quality of life of cranial WHO grade I meningioma patients: are current questionnaires relevant? Full Text available with Trip Pro

Health-related quality of life of cranial WHO grade I meningioma patients: are current questionnaires relevant? The clinical relevance of Health-Related Quality of Life (HRQoL) in meningioma patients has been increasingly acknowledged in recent years. Various questionnaires have been used. However, almost none of these questionnaires has been particularly developed for and/or validated in this patient group. Therefore, the aim of this study was to assess the relevance and comprehensiveness (...) relevant), (2) assess the ten most important issues, and (3) identify new relevant HRQoL issues.Fourteen different questionnaires were found in the literature, comprising 140 unique issues. Interviews were conducted with 20 patients (median age 57, 71% female) and 10 HCPs (4 neurosurgeons, 2 neurologists, 2 radiotherapists, 1 rehabilitation specialist, 1 neuropsychologist; median experience 13 years). Meningioma patients rated 17-80% of the issues in each of the questionnaires as relevant, HCPs 90-100

2017 Acta neurochirurgica

232. Effects of vacuum sealing drainage on the treatment of cranial bone-exposed wounds in rabbits Full Text available with Trip Pro

Effects of vacuum sealing drainage on the treatment of cranial bone-exposed wounds in rabbits This study was designed to assess the efficacy of vacuum sealing drainage (VSD) on skull exposure wounds in rabbits and to investigate the underlying mechanism of the process. Full-thickness excisional circular wounds 2×2 cm with or without periosteum involvement were created in 88 New Zealand white rabbits (mean body weight: 3.0±0.65 kg). Animals were randomly divided into 4 groups: periosteum-intact (...) the wound healing process significantly (P<0.05) compared to the corresponding control groups. VSD alleviated the inflammation reaction, accelerated re-epithelialization and facilitated the organization of collagen fibers into neat rows. During the wound healing process, the hydroxyproline content increased overtime [i.e., postoperative days (POD) 7, POD 10 and POD 15] in all four groups, and it peaked in the p+VSD group. VSD also promoted angiogenesis via increasing number and quality of collagen. We

2017 Brazilian Journal of Medical and Biological Research

233. Prophylactic cranial irradiation for stage IV small cell lung cancer, live longer or reduce morbidity of brain metastases? Full Text available with Trip Pro

Prophylactic cranial irradiation for stage IV small cell lung cancer, live longer or reduce morbidity of brain metastases? 29268344 2018 11 13 2072-1439 9 10 2017 Oct Journal of thoracic disease J Thorac Dis Prophylactic cranial irradiation for stage IV small cell lung cancer, live longer or reduce morbidity of brain metastases? 3572-3575 10.21037/jtd.2017.09.50 Postmus Pieter E PE Department of Medical Oncology, Clatterbridge Cancer Centre, Liverpool Heart & Chest Hospital, University (...) of Liverpool, Liverpool, UK. Smit Egbert F EF Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands. eng Editorial Comment China J Thorac Dis 101533916 2072-1439 Lancet Oncol. 2017 May;18(5):663-671 28343976 Conflicts of Interest: The authors have no conflicts of interest to declare. 2017 12 23 6 0 2017 12 23 6 0 2017 12 23 6 1 ppublish 29268344 10.21037/jtd.2017.09.50 jtd-09-10-3572 PMC5723843 Eur J Cancer. 1997 Oct;33(11):1752-8 9470828 Cancer. 2008 Apr 15;112(8):1827

2017 Journal of thoracic disease

234. Prophylactic Cranial Irradiation Following Surgical Resection of Early-Stage Small-Cell Lung Cancer: A Review of the Literature Full Text available with Trip Pro

Prophylactic Cranial Irradiation Following Surgical Resection of Early-Stage Small-Cell Lung Cancer: A Review of the Literature With increasing use of low-dose screening CT scans, the diagnosis of early-stage small-cell lung cancer (SCLC) without evidence of mediastinal nodal or distant metastasis is likely to become more common, but the role of adjuvant therapies such as prophylactic cranial irradiation (PCI) are not well understood in this population. We performed a review of the literature (...) pertaining to the impact of PCI in patients who underwent surgical resection of early-stage SCLC. Four studies were identified that were pertinent including three single-institution retrospective analyses and a National Cancer Database analysis. Based upon these studies, we estimate the rate of brain metastases to be 10-15% for Stage I and 15-25% for Stage II disease without PCI. However, the impact of PCI on the development of brain metastases and its ultimate impact on overall survival were

2017 Frontiers in oncology

235. Obsessive-Compulsive Disorder Associated with Posterior Cranial Fossa Meningioma Full Text available with Trip Pro

criteria such as depression. One month after giving childbirth, the symptoms worsened, while headache and dizziness also developed. The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score was 34. The patient was examined for a headache and a posterior cranial fossa meningioma was found. Following resection of the meningioma, the OCD symptoms were remarkably reduced (Y-BOCS score 10). There is only one previous report of pure OCD associated with a cerebellar mass and the present findings should help (...) Obsessive-Compulsive Disorder Associated with Posterior Cranial Fossa Meningioma We report here a patient in whom the effects of a cerebellum mass may have led to development of obsessive-compulsive disorder (OCD). A 33-year-old woman showed symptoms of OCD, including obsessive worry about infection from tainted blood and repetitive confirmation, which worsened during pregnancy. She had comprehension in regard to her illness and no evidence of cognitive dysfunction and did not meet other DSM-5

2017 Case reports in psychiatry

236. Low‐level laser therapy (780 nm) combined with collagen sponge scaffold promotes repair of rat cranial critical‐size defects and increases TGF‐β, FGF‐2, OPG/RANK and osteocalcin expression Full Text available with Trip Pro

Low‐level laser therapy (780 nm) combined with collagen sponge scaffold promotes repair of rat cranial critical‐size defects and increases TGF‐β, FGF‐2, OPG/RANK and osteocalcin expression The aim of this study was to evaluate the effect of collagen sponge scaffold (CSS) implantation associated with low-level laser therapy (LLLT) on repairing bone defects. A single 5-mm cranial defect was surgically created in forty Wistar rats, which then received one of the following four (...) interventions (n = 10 per group): no treatment (G0); bone defect implanted with collagen sponge scaffold (CSS) alone (G1); defect treated with low-level laser therapy (LLLT) (wavelength 780 nm; total energy density 120 J/cm2 ; power 50 mW) alone (G2); and CSS associated with LLLT treatment (G3). After surgery, animals in each group were euthanized at 21 days and 30 days (n = 5 per euthanasia time group). Bone formation was monitored by X-ray imaging analysis. Biopsies were collected and processed

2017 International journal of experimental pathology

237. Commentary: Complete Cranial Iliac Osteotomy to Approach the Lumbosacral Foramen Full Text available with Trip Pro

Commentary: Complete Cranial Iliac Osteotomy to Approach the Lumbosacral Foramen 28717639 2018 11 13 2297-1769 4 2017 Frontiers in veterinary science Front Vet Sci Commentary: Complete Cranial Iliac Osteotomy to Approach the Lumbosacral Foramen. 106 10.3389/fvets.2017.00106 Saulnier Troff Francois-Guillaume FG Soft Tissue/Orthopaedics/Neurosurgery Department, Veterinary Emergency and Specialty Hospital, Singapore. Motta Luca L Northwest Surgeons, Frodsham, United Kingdom. De Busscher Virginie V (...) Diagnostic Imaging Department, Veterinary Emergency and Specialty Hospital, Singapore. eng Journal Article Comment 2017 07 03 Switzerland Front Vet Sci 101666658 2297-1769 Front Vet Sci. 2017 May 19;4:75 28580360 dogs foraminotomy ilium lumbosacral region transiliac 2017 05 31 2017 06 20 2017 7 19 6 0 2017 7 19 6 0 2017 7 19 6 1 epublish 28717639 10.3389/fvets.2017.00106 PMC5494476 J Am Vet Med Assoc. 2002 Sep 15;221(6):807-10, 800 12322918 Vet Surg. 2007 Oct;36(7):705-13 17894598 Front Vet Sci. 2017 May

2017 Frontiers in veterinary science

238. Highly Conformal Craniospinal Radiotherapy Techniques Can Underdose the Cranial Clinical Target Volume if Leptomeningeal Extension through Skull Base Exit Foramina is not Contoured Full Text available with Trip Pro

Highly Conformal Craniospinal Radiotherapy Techniques Can Underdose the Cranial Clinical Target Volume if Leptomeningeal Extension through Skull Base Exit Foramina is not Contoured Craniospinal irradiation (CSI) remains a crucial treatment for patients with medulloblastoma. There is uncertainty about how to manage meningeal surfaces and cerebrospinal fluid (CSF) that follows cranial nerves exiting skull base foramina. The purpose of this study was to assess plan quality and dose coverage (...) of posterior cranial fossa foramina with both photon and proton therapy.We analysed the radiotherapy plans of seven patients treated with CSI for medulloblastoma and primitive neuro-ectodermal tumours and three with ependymoma (total n = 10). Four had been treated with a field-based technique and six with TomoTherapy™. The internal acoustic meatus (IAM), jugular foramen (JF) and hypoglossal canal (HC) were contoured and added to the original treatment clinical target volume (Plan_CTV) to create a Test_CTV

2017 Clinical Oncology (Royal College of Radiologists (Great Britain)

239. Cranial Neuropathies and Neuromuscular Weakness: A Case of Mistaken Identity Full Text available with Trip Pro

Cranial Neuropathies and Neuromuscular Weakness: A Case of Mistaken Identity We describe a case of wound botulism initially thought to represent Miller-Fisher variant Guillain-Barré syndrome (MFS). Botulism classically presents with the so-called "four D's" (diplopia, dysarthria, dysphagia, dry mouth) with symmetric, descending weakness. MFS presents with a triad of limb-ataxia, areflexia, and ophthalmoplegia, with variable cranial nerve and extremity involvement. The distinction can

2017 Clinical Practice and Cases in Emergency Medicine

240. Analyses of distribution and dosimetry of brain metastases in small cell lung cancer with relation to the neural stem cell regions: feasibility of sparing the hippocampus in prophylactic cranial irradiation Full Text available with Trip Pro

Analyses of distribution and dosimetry of brain metastases in small cell lung cancer with relation to the neural stem cell regions: feasibility of sparing the hippocampus in prophylactic cranial irradiation This work aims to assess the feasibility of selectively sparing the hippocampus during prophylactic cranial irradiation (PCI) for small cell lung cancer (SCLC).SCLC patients with brain metastases (BMs) diagnosed with MRI were enrolled. Lesions localized to the neural stem cell (NSC (...) ) compartments [subventricular zone (SVZ) or hippocampus] were analyzed. Patients were categorized by the total number of intracranial metastases, the therapy processes and the symptoms. Hippocampi and enhanced lesions within 15 mm from the hippocampus were contoured. IMRT treatment plans were generated for hippocampal avoidance (HA)-PCI (25Gy in 10 fractions).From Jan 2011 to Oct 2014, 1511 metastases were identified in 238 patients. The overall ratio of metastatic lesions located in NSC regions was 2.0

2017 Radiation oncology (London, England)

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