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Cranial Nerve 10

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181. Prophylactic cranial irradiation in small-cell lung cancer: update on patient selection, efficacy and outcomes (Full text)

Prophylactic cranial irradiation in small-cell lung cancer: update on patient selection, efficacy and outcomes Over 10% of small-cell lung cancer (SCLC) patients have brain metastases (BM) at initial diagnosis; more than 50% will develop BM within 2 years. BM are detected in up to 80% of all patients at autopsy. After primary treatment, prophylactic cranial irradiation (PCI) has been established as standard of care in SCLC patients responding to initial therapy. Based on level I evidence, PCI

2018 Lung Cancer: Targets and Therapy PubMed

182. Point-of-care Cranial Ultrasound in a Hemicraniectomy Patient (Full text)

Point-of-care Cranial Ultrasound in a Hemicraniectomy Patient 30443636 2018 12 07 2474-252X 2 4 2018 Nov Clinical practice and cases in emergency medicine Clin Pract Cases Emerg Med Point-of-care Cranial Ultrasound in a Hemicraniectomy Patient. 375-377 10.5811/cpcem.2018.7.39379 Sarwal Aarti A Wake Forest School of Medicine, Department of Neurology, Winston-Salem, North Carolina. Elder Natalie M NM Wake Forest School of Medicine, Department of Emergency Medicine, Winston-Salem, North Carolina (...) . eng Journal Article 2018 09 10 United States Clin Pract Cases Emerg Med 101718968 2474-252X Conflicts of Interest: By the CPC-EM article submission agreement, all authors are required to disclose all affiliations, funding sources and financial or management relationships that could be perceived as potential sources of bias. The authors disclosed none. 2018 06 13 2018 06 19 2018 07 19 2018 11 17 6 0 2018 11 18 6 0 2018 11 18 6 1 epublish 30443636 10.5811/cpcem.2018.7.39379 cpcem-02-375 PMC6230339

2018 Clinical Practice and Cases in Emergency Medicine PubMed

183. Involvement of Calvarial Stem Cells in Healing: A Regional Analysis of Large Cranial Defects. (PubMed)

Involvement of Calvarial Stem Cells in Healing: A Regional Analysis of Large Cranial Defects. Large craniofacial defects present a substantial clinical challenge that often requires the use of osteoconductive matrices and osteoinductive cues (i.e., bone morphogenetic proteins [BMP2]) to augment healing. While these methods have improved clinical outcomes, a better understanding of how the osteogenic fronts surrounding the defect, the underlying dura mater, and the cranial suture area contribute (...) to healing may lead to more targeted therapies to enhance bone regeneration. We hypothesized that healing within a large bone defect will be precipitated from cells within the remaining or available suture mesenchyme abutting the edges of a murine critical sized defect. To investigate this hypothesis, 39 adult, wild-type mice were randomly arranged into groups (9 or 10 per group) by time (4 and 8 weeks) and treatment (control, acellular collagen sponge alone, or acellular collagen sponge loaded

2018 Wound Repair and Regeneration

184. Penetration of the blood-brain barrier by avitinib and its control of intra/extra-cranial disease in non-small cell lung cancer harboring the T790M mutation. (PubMed)

Penetration of the blood-brain barrier by avitinib and its control of intra/extra-cranial disease in non-small cell lung cancer harboring the T790M mutation. Avitinib is an oral, potent, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor selective for the EGFR T790 M mutation. We report the safety, intra-/extracranial efficacy, and the blood-brain barrier (BBB) penetration rate of avitinib (NCT02330367).Non-small cell lung cancer (NSCLC) patients with the EGFR T790 M (...) ) and 536 days (95%CI: 363.6-708.4), respectively. The median intracranial PFS of seven brain metastases patients was 142 days (95% CI 31.1-252.9). Blood and cerebrospinal fluid analysis of five brain metastases patients showed the BBB penetration rate to be 0.046%-0.146%. The most frequent adverse events were mild and reversible hepatic transaminases elevating (10/16, 62.5%) and diarrhea (4/16, 25.0%).Avitinib is well tolerated and efficacious in T790M-positive patients. Its penetrability to the BBB is weak

2018 Lung Cancer

185. Characteristics, outcome and treatments with cranial pachymeningitis: A multicenter French retrospective study of 60 patients. (Full text)

, female/male ratio 0.43). Neurologic signs were present in 59 patients (98%) and consisted of headache in 43 (72%), cranial nerve palsy in 33 (55%), confusion in 10 (17%), seizures in 7 (12%), and focal neurologic signs in 9 (15%). Fever and weight loss were present in 8 (13%) and 13 cases (22%), respectively. Cerebral venous thrombosis was present in 8 cases (13%). Analysis of cerebrospinal fluid showed moderate hyperproteinorachia (median 0.68 g/L; IQR 0.46-3.2) with or without pleiocytosis (...) Characteristics, outcome and treatments with cranial pachymeningitis: A multicenter French retrospective study of 60 patients. The aim of this study was to determine the characteristics, treatment, and outcome according to each etiology of pachymeningitis.We conducted a retrospective multicenter French nationwide study between 2000 and 2016 to describe the characteristics, outcome, and treatment of pachymeningitis.We included 60 patients (median age 55.5 years; interquartile range [IQR] 30-80

2018 Medicine PubMed

186. Tumor spontaneous regression in an elderly patient with Squamous Cell Carcinoma of the cranial vertex pre-treated with cetuximab monotherapy. (Full text)

Tumor spontaneous regression in an elderly patient with Squamous Cell Carcinoma of the cranial vertex pre-treated with cetuximab monotherapy. 30117145 2019 01 03 1365-2133 180 1 2019 Jan The British journal of dermatology Br. J. Dermatol. Spontaneous regression of tumour in an elderly patient with squamous cell carcinoma of the cranial vertex pretreated with cetuximab monotherapy. 209-210 10.1111/bjd.17097 Ginocchi L L http://orcid.org/0000-0002-2278-7372 UO Oncologia, Ospedale San Luca di (...) Lucca, Lucca, 55100, Italy. Cirigliano G G UO Oncologia, Ospedale San Luca di Lucca, Lucca, 55100, Italy. Mazzatenta C C UO Dermatologia, Ospedale San Luca di Lucca, Lucca, 55100, Italy. Baldini E E EE UO Oncologia, Ospedale San Luca di Lucca, Lucca, 55100, Italy. eng Letter 2018 10 21 England Br J Dermatol 0004041 0007-0963 2018 8 18 6 0 2018 8 18 6 0 2018 8 18 6 0 ppublish 30117145 10.1111/bjd.17097

2018 British Journal of Dermatology PubMed

187. Multiple Cranial Neuropathies in a Patient with Diffuse Large B-cell Lymphoma: Case Report and Review of Literature (Full text)

Multiple Cranial Neuropathies in a Patient with Diffuse Large B-cell Lymphoma: Case Report and Review of Literature Neuropathies can occur in patients with diffuse large B-cell lymphoma (DLBCL) at any stage of the disease as a presenting symptom or during later stages of illness. A wide spectrum of neurological association is known to occur with DLBCL, ranging from cranial nerve palsies to peripheral neuropathies. Evaluation of cranial and peripheral neuropathies in patients with DLBCL requires (...) meticulous clinical, imaging, and electrodiagnostic testing. A 75-year-old right-handed female with a known history of multiple cranial neuropathies and DLBCL presented with acute dysphagia and upper extremity weakness of one-week duration. On evaluation, she was found to have right vagal nerve palsy. Cerebrospinal fluid (CSF) analysis along with flow cytometry testing showed CD19 and CD20 positive B cells, confirming neoplastic infiltration of CSF. We describe the case and review the literature

2018 Cureus PubMed

188. Institutional experience with SRS VMAT planning for multiple cranial metastases (Full text)

Institutional experience with SRS VMAT planning for multiple cranial metastases This study summarizes the cranial stereotactic radiosurgery (SRS) volumetric modulated arc therapy (VMAT) procedure at our institution.Volumetric modulated arc therapy plans were generated for 40 patients with 188 lesions (range 2-8, median 5) in Eclipse and treated on a TrueBeam STx. Limitations of the custom beam model outside the central 2.5 mm leaves necessitated more than one isocenter pending the spatial (...) to PTV volume a predicted GI = 4/PTV0.2 was determined and implemented in a script in Eclipse and used for plan evaluation. Brain volume receiving 7 Gy (V7 Gy ) ranged 10-136 cm3 (median 42 cm3 ). Total treatment time ranged 24-138 min (median 61 min).Volumetric modulated arc therapy provide plans with steep dose gradients around the targets and low dose to critical structures, and VMAT treatment is delivered in a shorter time than conventional methods using one isocenter per lesion. To further

2018 Journal of Applied Clinical Medical Physics PubMed

189. Short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms in NMOSD (Full text)

Short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms in NMOSD 29484308 2018 11 13 2332-7812 5 3 2018 May Neurology(R) neuroimmunology & neuroinflammation Neurol Neuroimmunol Neuroinflamm Short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms in NMOSD. e447 10.1212/NXI.0000000000000447 Mizuno Yuri Y Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Shinoda Koji (...) Sciences, Kyushu University, Fukuoka, Japan. Kira Jun-Ichi JI Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. eng Journal Article 2018 02 21 United States Neurol Neuroimmunol Neuroinflamm 101636388 2332-7812 2017 10 21 2018 01 05 2018 2 28 6 0 2018 2 28 6 0 2018 2 28 6 1 epublish 29484308 10.1212/NXI.0000000000000447 NEURIMMINFL2017015123 PMC5822750 Cephalalgia. 2006 Feb;26(2):221-4 16426279 Mult Scler. 2014 Jun;20(7):843-7

2018 Neurology® neuroimmunology & neuroinflammation PubMed

190. Successful rituximab treatment of granulomatosis with polyangiitis with cranial neuropathies (Full text)

Successful rituximab treatment of granulomatosis with polyangiitis with cranial neuropathies In granulomatosis with polyangiitis (GPA), peripheral nerve involvement is common but central nervous system (CNS) involvement is extremely rare and treatment strategy has not been established. We report a case of intravenous cyclophosphamide (IVCY)-resistant GPA with associated cranial neuropathies that was successfully treated with rituximab (RTX).A 37-year-old man with intractable sinusitis had (...) with cranial neuropathies.GPA with cranial neuropathies might be useful with RTX as induction therapy.

2018 Inflammation and regeneration PubMed

191. Prophylactic cranial irradiation for limited-stage small-cell lung cancer patients: secondary findings from the prospective randomized phase 3 CONVERT trial. (PubMed)

Prophylactic cranial irradiation for limited-stage small-cell lung cancer patients: secondary findings from the prospective randomized phase 3 CONVERT trial. The impact of the dose and fractionation of thoracic radiotherapy on the risk of developing brain metastasis (BM) has not been evaluated prospectively in limited stage SCLC patients receiving prophylactic cerebral irradiation (PCI).Data from patients treated with PCI from the CONVERT trial were analyzed.Four hundred forty-nine of 547 (...) , weight loss of more than 10%, and tGTV were prognostic factors associated with OS. In the multivariate analysis, only tGTV was associated with OS. Delay between end of chemotherapy and PCI was not associated with OS.Patients receiving OD or BD thoracic radiotherapy have the same risk of developing BM. Larger tumors are associated with a higher risk of BM.Copyright © 2018 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

2018 Journal of Thoracic Oncology

192. Use of collagen/chitosan sponges mineralized with hydroxyapatite for the repair of cranial defects in rats. (PubMed)

Use of collagen/chitosan sponges mineralized with hydroxyapatite for the repair of cranial defects in rats. In traumatology, we encounter several clinical challenges that involve extensive bone loss primarily related to trauma, conditions that can be treated with autologous grafts. A good alternative is the use of synthetic biomaterials as substitutes. These polymers provide a suitable environment for the growth of new bone and vascular tissue, which are essential for repair. Collagen (...) animals were used for the creation of a defect in the left parietal bone and were divided into three groups of 10 animals each: a control group without biomaterial implantation, a group receiving the blend of collagen and chitosan, and a group receiving this blend combined with hydroxyapatite. Each group was subdivided and the animals were sacrificed 3 or 8 weeks after surgery. After sacrifice, the skulls were removed for macroscopic photodocumentation and radiographic examination. The samples were

2018 Injury

193. Application of Ultrasonic Bone Aspirator for Decompression of the Internal Auditory Canal via the Middle Cranial Fossa Approach. (PubMed)

Application of Ultrasonic Bone Aspirator for Decompression of the Internal Auditory Canal via the Middle Cranial Fossa Approach. Evaluate the safety and efficacy of the ultrasonic bone aspirator (UBA) during middle cranial fossa (MCF) approach to vestibular schwannoma (VS).Retrospective case series.Tertiary referral center.Charts of 192 consecutive VS patients over 18 years of age were reviewed to identify 65 patients who underwent MCF approach to VS resection between 2006 and 2017 (...) . A combination of UBA and high-speed drill (HSD) was used to decompress the internal auditory canal (IAC) in 25 patients and HSD alone was used in the other 40 patients.Use of UBA during vestibular schwannoma surgery via MCF approach for decompression of the IAC.Postoperative facial nerve outcomes assessed by the House-Brackmann (HB) facial nerve grading scale. Rates of gross total resection (GTR) and cerebrospinal fluid (CSF) leak.There were no significant differences in postoperative facial nerve function

2018 Otology and Neurotology

194. Symptom Burden Associated With Late Lower Cranial Neuropathy in Long-term Oropharyngeal Cancer Survivors. (PubMed)

Symptom Burden Associated With Late Lower Cranial Neuropathy in Long-term Oropharyngeal Cancer Survivors. Lower cranial neuropathy (LCNP) is a rare but potentially disabling result of radiotherapy and other head and neck cancer therapies. Survivors who develop late LCNP may experience profound functional impairment, with deficits in swallowing, speech, and voice.To investigate the association of late LCNP with severity of cancer treatment-related symptoms and subsequent general functional (...) impairment among oropharyngeal cancer (OPC) survivors.This cross-sectional survey study analyzed 889 OPC survivors nested within a retrospective cohort of OPC survivors treated at MD Anderson Cancer Center from January 1, 2000, to December 31, 2013. Eligible survey participants were disease free and completed OPC treatment 1 year or more before the survey. Data analysis was performed from October 10, 2017, to March 15, 2018.Late LCNP defined by onset 3 months or more after cancer therapy.The primary

2018 JAMA otolaryngology-- head & neck surgery

195. Varicella zoster presenting as cranial polyneuropathy. (PubMed)

Varicella zoster presenting as cranial polyneuropathy. Cranial polyneuropathy is commonly caused by Lyme disease. We discuss the case of a man who presented with cranial nerve deficits causing dysphagia, dysphonia and facial weakness. This diagnostic dilemma stemmed from a workup that ruled out Lyme and vascular causes leading to an expanded search for infectious explanations, which revealed varicella zoster in the cerebrospinal fluid. On review, this phenomenon is rarely reported, but has been (...) observed with a number of herpes family viruses. In emergency department settings, clinical suspicion should be raised for VZV infection even in the absence of rash in patients that present with multiple cranial nerve palsies.Copyright © 2018. Published by Elsevier Inc.

2018 American Journal of Emergency Medicine

196. CRACKCast 107 – Peripheral Nerve Disorders

= Central Nervous System + Peripheral Nervous System PNS divided into 12 cranial nerves (Remember episode 105?) 31 spinal nerves (8 cervical, 12 thoracic, 5 lumbar, 5 sacral, and 1 coccygeal). Almost all of these nerves have Sensory, Motor and autonomic function Anatomically / functionally speaking the autonomic nervous system is divided into: Sympathetic (thoracolumbar) component Parasympathetic (craniosacral) component. Note: Autonomic dysfunction may cause systemic abnormalities (e.g., Orthostasis (...) Vasospastic (deep buttock injection) Neoplastic Radiation Idiopathic lumbosacral plexitis Infectious Herpesvirus (sacrococygeal) Herpes simplex 2 Herpes zoster Cytomegalovirus polyradiculopathy (HIV infection) Isolated mononeuropathies (broad categories): Upper extremity Radial nerve Ulnar nerve Median nerve Lower extremity Sciatic nerve Femoral nerve Lateral femoral cutaneous (meralgia paresthetica) Peroneal nerve Tibial nerve Sural nerve Plantar nerve Obturator mononeuropathy [10] What are two other

2017 CandiEM

197. Prognostic value of magnetic resonance imaging-detected cranial nerve invasion in nasopharyngeal carcinoma. (Full text)

Prognostic value of magnetic resonance imaging-detected cranial nerve invasion in nasopharyngeal carcinoma. We previously reported that magnetic resonance imaging evidence of cranial nerve invasion was an unfavourable prognostic factor in nasopharyngeal carcinoma. However, the prognostic value of this evidence in nasopharyngeal carcinoma treated with intensity-modulated radiotherapy remains unknown.We retrospectively analysed 749 nasopharyngeal carcinoma patients who underwent intensity (...) -modulated radiotherapy.Cranial nerve invasion was observed in 299 (39.9%) patients with T3-4 disease. In T3-4 nasopharyngeal carcinoma, magnetic resonance imaging-detected cranial nerve invasion was associated with inferior 5-year overall survival, distant metastasis-free survival, and locoregional relapse-free survival (P=0.002, 0.003, and 0.012, respectively). Multivariate analyses confirmed that cranial nerve invasion was an independent prognostic factor for distant metastasis-free survival (hazard

2014 British Journal of Cancer PubMed

198. Systematic Review and Meta-Analysis of Noninvasive Cranial Nerve Neuromodulation for Nervous System Disorders. (PubMed)

Systematic Review and Meta-Analysis of Noninvasive Cranial Nerve Neuromodulation for Nervous System Disorders. To systematically review the medical literature and comprehensively summarize clinical research done on rehabilitation with a novel portable and noninvasive electrical stimulation device called the cranial nerve noninvasive neuromodulator in patients suffering from nervous system disorders.PubMed, MEDLINE, and Cochrane Database of Systematic Reviews from 1966 to March 2013.Studies were (...) included if they recruited adult patients with peripheral and central nervous system disorders, were treated with the cranial nerve noninvasive neuromodulator device, and were assessed with objective measures of function.After title and abstract screening of potential articles, full texts were independently reviewed to identify articles that met inclusion criteria.The search identified 12 publications: 5 were critically reviewed, and of these 5, 2 were combined in a meta-analysis. There were

2014 Archives of physical medicine and rehabilitation

199. Detection of third and sixth cranial nerve palsies with a novel method for eye tracking while watching a short film clip. (Full text)

Detection of third and sixth cranial nerve palsies with a novel method for eye tracking while watching a short film clip. Automated eye movement tracking may provide clues to nervous system function at many levels. Spatial calibration of the eye tracking device requires the subject to have relatively intact ocular motility that implies function of cranial nerves (CNs) III (oculomotor), IV (trochlear), and VI (abducent) and their associated nuclei, along with the multiple regions of the brain (...) , or surgically treatable pathological conditions potentially impacting these nerves. The authors compared the ratio of vertical to horizontal eye movement (height/width defined as aspect ratio) in normal and test subjects.In 157 normal controls, the aspect ratio (height/width) for the left eye had a mean value ± SD of 1.0117 ± 0.0706. For the right eye, the aspect ratio had a mean of 1.0077 ± 0.0679 in these 157 subjects. There was no difference between sexes or ages. A patient with known CN VI palsy had

2014 Journal of Neurosurgery PubMed

200. Cranial-nerve Non-invasive Neuromodulation (CN-NINM) for Balance Deficits After Mild Traumatic Brain Injury (Full Trial)

Cranial-nerve Non-invasive Neuromodulation (CN-NINM) for Balance Deficits After Mild Traumatic Brain Injury (Full Trial) Cranial-nerve Non-invasive Neuromodulation (CN-NINM) for Balance Deficits After Mild Traumatic Brain Injury (Full Trial) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Cranial-nerve Non-invasive Neuromodulation (CN-NINM) for Balance Deficits After Mild Traumatic Brain Injury (Full Trial) (CN-NINM) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02125591 Recruitment Status

2014 Clinical Trials

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