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121. Effect of air, anesthetic gas mixture, saline, or 2% lignocaine used for tracheal tube cuff inflation on coughing and laryngotracheal morbidity after tracheal extubation. (Abstract)

Effect of air, anesthetic gas mixture, saline, or 2% lignocaine used for tracheal tube cuff inflation on coughing and laryngotracheal morbidity after tracheal extubation. Coughing and sore throat postoperatively are common clinical problems during general anesthesia which can be avoided by various methods including topicalization of airway with local anesthetics, endotracheal tube cuff (ETT) inflation with local anesthetics, use of intravenous drugs such as dexamethasone, maintaining ETT cuff (...) pressure, intubation by an experienced anethesiologist, etc. The aims of the study were to compare postextubation coughing response, mean number of cuff deflations required intraoperatively, and postoperative airway morbidity in terms of sore throat (2 h and 18-24 h), hoarseness of voice, and dysphagia following inflation of ETT cuff with air, anesthetic gas mixture, saline, and 2% lignocaine during general anesthesia.One hundred and four patients were randomized into 1 of 4 groups depending on whether

2019 Journal of anaesthesiology, clinical pharmacology Controlled trial quality: uncertain

122. Efficacy and Safety of Using Air Versus Alkalinized 2% Lignocaine for Inflating Endotracheal Tube Cuff and Its Pressure Effects on Incidence of Postoperative Coughing and Sore Throat. (Full text)

Efficacy and Safety of Using Air Versus Alkalinized 2% Lignocaine for Inflating Endotracheal Tube Cuff and Its Pressure Effects on Incidence of Postoperative Coughing and Sore Throat. We wished to compare the endotracheal tube (ETT) cuff pressure inflated with air or alkalinized lignocaine during anesthesia and evaluate clinical symptoms such as coughing and sore throat (postoperative sore throat [POST]) following tracheal extubation.This was a prospective randomized controlled study conducted (...) manometer. After extubation, an independent observer blinded to study group recorded the presence or absence of coughing and POST at immediately, 1 h and 24 h postoperatively.Demographic data, baseline characteristics (American Society of Anesthesiologists grade, intracuff volume/cuff pressure at start of surgery), and duration of anesthesia were comparable among study groups (P > 0.05). Cuff pressure and volume achieved in the end of surgery were much higher in air group as compared to lignocaine group

2019 Anesthesia, essays and researches Controlled trial quality: uncertain PubMed abstract

123. [Clinical effect of fluticasone propionate, montelukast sodium and ketotifen in treatment of cough variant asthma in children]. (Abstract)

[Clinical effect of fluticasone propionate, montelukast sodium and ketotifen in treatment of cough variant asthma in children]. To study the clinical effect of different combinations of fluticasone propionate (Flu), montelukast sodium (Mon) and ketotifen (Ket) in the treatment of children with cough variant asthma (CVA).A total of 280 children with CVA who were admitted to the department of respiratory medicine from June 2015 to January 2018 were randomly divided into Flu+Mon+Ket, Flu+Mon, Flu (...) +Ket, Mon+Ket, Flu, Mon and Ket groups, with 40 children in each group. The children in each group were given corresponding drug(s), and the course of treatment was 3 months for all groups. The condition of cough, cough symptom score, pulmonary function and adverse drug reactions were evaluated after 2 and 3 months of treatment. The children were followed up to observe recurrence.After treatment, cough symptom score tended to decrease in all 7 groups, with increases in percentage of forced

2019 Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics Controlled trial quality: uncertain

124. [Clinical trial of acupuncture treatment of gastroesophageal reflux cough by needling dorsal segment of the Governor Vessel]. (Abstract)

[Clinical trial of acupuncture treatment of gastroesophageal reflux cough by needling dorsal segment of the Governor Vessel]. To observe the curative effect of acupuncture stimulation of the back segment (10 spots below the spinous processes from T3 to T12) of the Governor Vessel in the treatment of gastroesophageal reflux cough (GERC).A total of 60 cases of GERC patients were randomly divided into acupuncture and medication groups (n=30 in each). For patients of the acupuncture group (...) , acid regurgitation and food regurgitation, 0-40 points), cough symptom score (0-3 points) and "Leicester Cough Questionnaire" (LCQ, scores of physiological, psychological and social functions, 0-21 points), respectively.Following the treatment, RDQ score and cough symptom scores during both daytime and night were significantly decreased in both groups (P<0.05),and the scores of physiological status, psychological health and social function of LCQ were significantly increased in both acupuncture

2019 Zhen ci yan jiu = Acupuncture research Controlled trial quality: uncertain

125. Montelukast and Budesonide for Childhood Cough Variant Asthma. (Full text)

Montelukast and Budesonide for Childhood Cough Variant Asthma. To determine the effects of combined treatment of montelukast and budesonide on young children with cough variant asthma, and their serum inflammatory factors of serum hypersensitive c-reactive protein (hs-CRP), tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6) and pulmonary function.An experimental study.The Second Affiliated Hospital of Xi'an Jiaotong University, China, from January 2016 to January 2017.A total of 112 (...) children with cough variant asthma were randomly divided into observation group and control group with 56 cases in each group. All children were treated with antibiotics and resolving phlegm. The control group were given budesonide, while the observation group was treated additionally with montelukast. After the course, improvement time of clinical symptoms of cough, asthma, etc., changes in levels of serum inflammatory factors of hs-CRP, TNF-α and IL-6, and pulmonary function indexes of forced vital

2019 Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Controlled trial quality: uncertain PubMed abstract

126. Comparison of Usefulness of Ketamine and Magnesium Sulfate Nebulizations for Attenuating Postoperative Sore Throat, Hoarseness of Voice, and Cough. (Full text)

Comparison of Usefulness of Ketamine and Magnesium Sulfate Nebulizations for Attenuating Postoperative Sore Throat, Hoarseness of Voice, and Cough. Postoperative sore throat (POST) is a complication that is unresolved in patients undergoing endotracheal intubation.To compare the effects of ketamine and magnesium sulfate nebulizations in two strengths, on the incidence and severity of POST, hoarseness, and cough.Sixty surgical patients undergoing elective abdominal and lower limb surgeries under (...) combined epidural and general anesthesia were included in this prospective, randomized, double-blinded study.Patients in each group were nebulized with the respective study drug 15 min prior to the surgery, i.e., ketamine in Group K, magnesium sulfate 250 mg, and 500 mg in Group M1 and Group M2, respectively, and normal saline as control in Group C. A standardized anesthesia protocol was followed for all patients. After extubation, the patients were asked to grade POST, hoarseness, and cough at 0, 2, 4

2019 Anesthesia, essays and researches Controlled trial quality: uncertain PubMed abstract

127. The Effect of Aclidinium on Symptoms Including Cough in Chronic Obstructive Pulmonary Disease: A Phase 4, Double-Blind, Placebo-controlled, Parallel-Group Study. (Full text)

The Effect of Aclidinium on Symptoms Including Cough in Chronic Obstructive Pulmonary Disease: A Phase 4, Double-Blind, Placebo-controlled, Parallel-Group Study. 30951372 2019 10 27 1535-4970 200 5 2019 Sep 01 American journal of respiratory and critical care medicine Am. J. Respir. Crit. Care Med. The Effect of Aclidinium on Symptoms Including Cough in Chronic Obstructive Pulmonary Disease: A Phase 4, Double-Blind, Placebo-controlled, Parallel-Group Study. 642-645 10.1164/rccm.201901-0048LE (...) Lancet Respir Med. 2014 Mar;2(3):195-203 24621681 Respir Med. 2015 Jan;109(1):88-95 25528948 Respir Res. 2014 Oct 07;15:124 25287629 Chest. 2009 Apr;135(4):975-982 19017866 Handb Exp Pharmacol. 2009;(187):311-20 18825348 Cough. 2013 Jun 24;9:17 23799979 COPD. 2014 Aug;11(4):451-8 24127996 Chest. 2000 Nov;118(5):1294-302 11083677 Chronic Obstr Pulm Dis. 2015 Dec 22;3(1):435-445 28848864 Eur Respir J. 2012 Oct;40(4):830-6 22441743 Chest. 2004 May;125(5):1726-34 15136383 Prim Care Respir J. 2012 Sep;21

2019 American Journal of Respiratory and Critical Care Medicine Controlled trial quality: uncertain PubMed abstract

128. Relationship of vocal fold atrophy to swallowing safety and cough function in Parkinson's disease. (Abstract)

Relationship of vocal fold atrophy to swallowing safety and cough function in Parkinson's disease. When swallowing function is compromised in patients with Parkinson's disease (PD), cough plays a crucial role in clearing the airway and preventing pulmonary complications. The aim of this study was to determine the influence of vocal fold atrophy severity as measured by the bowing index (BI) on airway protection in PD.Thirty participants with PD completed measures of voluntary and reflex cough (...) . Flexible laryngoscopy with endoscopic evaluation of swallowing allowed for measurement of BI using ImageJ software. Swallowing safety was scored on the Penetration-Aspiration Scale (PAS). Regression and receiver operating characteristic (ROC) analyses were performed to test our study aim.Twenty-four of 30 participants had some degree of vocal fold atrophy (BI >0). When controlling for age, disease duration did not significantly influence BI. BI was not predictive of any sensorimotor parameters of cough

2019 Laryngoscope

129. Open Airway Surgery in a Paraplegic: The Importance of an Adequate Cough. (Abstract)

Open Airway Surgery in a Paraplegic: The Importance of an Adequate Cough. To describe a case of open airway surgery with postoperative respiratory complications in a paraplegic woman and to review the unique respiratory physiology seen in patients with a history of cervical or thoracic spinal cord injury (SCI).Case report and literature review.We describe the case of a 25-year-old paraplegic who developed tracheal stenosis after tracheotomy, eventually requiring tracheal resection and re (...) -anastomosis. Her postoperative course was complicated by mucus plugging and severe atelectasis, necessitating reintubation. After extubation, the patient reported difficulty expectorating secretions ever since her SCI, requiring manual abdominal pressure from her family members to assist her when she needed to cough.This first report of cricotracheal resection in a patient with paraplegia following SCI highlights the importance of an adequate cough and demonstrates the unique respiratory management

2019 Rhinology and Laryngology

130. A 63-Year-Old Woman With Pulmonary Micronodules and Chronic Cough. (Abstract)

A 63-Year-Old Woman With Pulmonary Micronodules and Chronic Cough. A 63-year-old woman presented with a 2-year history of nonproductive cough. She denied the presence of shortness of breath, chest pain, arthralgia, muscle weakness, weight loss, night sweats, and fatigue. She was a never smoker and had a history of arterial hypertension and diabetes. There was no history of asthma, allergic rhinitis, nasal polyps, or gastroesophageal reflux disease, known malignancy, or collagen tissue disease

2019 Chest

131. The Neurokinin-1 Receptor Antagonist Orvepitant is a Novel Antitussive Therapy for Chronic Refractory Cough: Results From a Phase 2 Pilot Study (VOLCANO-1). (Abstract)

The Neurokinin-1 Receptor Antagonist Orvepitant is a Novel Antitussive Therapy for Chronic Refractory Cough: Results From a Phase 2 Pilot Study (VOLCANO-1). Substance P and the neurokinin-1 (NK-1) receptor are implicated in chronic refractory cough pathophysiology. We assessed the efficacy and safety of orvepitant, a brain-penetrant NK-1 antagonist, in an open-label study in CRC patients with chronic refractory cough.Thirteen patients with daytime cough frequency >3 to <250 coughs/h took (...) orvepitant 30 mg once daily for 4 weeks. Objective cough frequency was measured over 24 h at baseline and weeks 1, 4, and 8. The primary end point was change from Baseline in daytime cough frequency at week 4. Secondary end points included cough severity visual analog scale (VAS) score, global ratings of change for cough frequency and severity, and Cough-specific Quality of Life Questionnaire score.All patients completed the study. Mean baseline cough frequency was 71.4/h. A statistically and clinically

2019 Chest

132. The "Cough Trick" Reduces Pain During Removal of Closed-suction Drains after Total Knee Arthroplasty: A Randomized Trial. (Abstract)

The "Cough Trick" Reduces Pain During Removal of Closed-suction Drains after Total Knee Arthroplasty: A Randomized Trial. Drain removal after TKA can be painful. Prior research suggests that the "cough trick," in which a patient coughs at the same time she or he receives an injection, effectively decreases pain. To our knowledge, this intervention has not been evaluated as a way to reduce pain during other brief but painful interventions, such as removal of closed-suction drains after (...) orthopaedic surgery.Does the cough trick reduce pain while a surgeon is removing a closed-suction drain after TKA?Fifty-six patients with primary osteoarthritis who underwent primary TKA were randomized into two groups: drain removal as the patient coughed (n = 28 patients; three men, 25 women) or drain removal using the usual process, without the cough trick (n = 28 patients; three men, 25 women). The study groups were not different in terms of gender, BMI, surgical time, or other baseline variables

2019 Clinical Orthopaedics and Related Research Controlled trial quality: uncertain

133. Application via mechanical dropper alleviates sufentanil-induced cough: a prospective, randomized, single-blinded trial. (Full text)

Application via mechanical dropper alleviates sufentanil-induced cough: a prospective, randomized, single-blinded trial. It was reported that prolonging the injection time or diluting administration can reduce the incidence of opioid-induced cough. However, the incidence of sufentanil-induced cough (SIC) via a standardized infusion rate is unclear. A mechanical dropper is an infusion filtering device commonly used for intravenous degassing; it can also be used to administer special drugs due (...) to its temporary storage and dilution effect. This study assesses the effectiveness of administration via mechanical dropper on SIC.Two hundred patients undergoing general anesthesia were enrolled. Patients received sufentanil at a strength of 0.3 μg·kg- 1 either via T-connector (group C) or by mechanical dropper (group M) at 1 ml·s- 1. Cough severity was graded as none (0), mild (1-2), moderate (3-5), or severe (> 5), and the incidence of SIC was evaluated for 5 min after the start of sufentanil

2019 Trials Controlled trial quality: uncertain PubMed abstract

134. Dual Tasking Influences Cough Sensorimotor Outcomes in Healthy Young Adults. (Abstract)

Dual Tasking Influences Cough Sensorimotor Outcomes in Healthy Young Adults. Purpose Reflex cough is an essential airway protective mechanism that often occurs in the context of divided attention. The effect of divided attention on measures of reflexive cough airflow and sensitivity remains unknown. We present findings from a study testing the effects of divided attention (via a dual-task paradigm) on measures of reflex cough in healthy young adults. Method Volunteers (N = 20, age = 20-40 years (...) ) underwent 4 blocks of capsaicin-induced cough challenges. Within each block, capsaicin ranging from 0 to 200 μM was presented in a randomized order. Two blocks consisted of cough testing only (single task). During the other 2 blocks, participants counted tones while simultaneously undergoing cough testing (dual task). Measures of cough motor response, self-reported urge-to-cough, cough frequency, and cough airflow were collected. Results Participants coughed more in the single-task condition compared

2019 Journal of speech, language, and hearing research : JSLHR Controlled trial quality: uncertain

135. A systematic review of methods of citric acid cough reflex testing. (Abstract)

A systematic review of methods of citric acid cough reflex testing. This systematic review summarises and appraises methods of citric acid cough reflex testing (CRT) documented in published literature.Electronic databases, MEDLINE, EMBASE, CINAHL, PsychINFO, Scopus were searched up to and including 11th February 2018. Studies reporting a method of citric acid CRT, published in peer-reviewed journals in English or Spanish, were assessed for the inclusion criteria. Of the selected studies (...) , information on the instrumentation and CRT protocol was extracted.A total of 129 studies were included. Instrumentation and protocols differed widely across studies. Reporting of methods of citric acid CRT was sub-standard, with many crucial methodological components omitted from published manuscripts, preventing their full replication.Considerable methodological variability exists for citric acid CRT in published literature. The findings suggest that caution is warranted in comparing citric acid cough

2019 Pulmonary Pharmacology & Therapeutics

136. Comparison of mannitol and citric acid cough provocation tests. (Abstract)

Comparison of mannitol and citric acid cough provocation tests. Citric acid has been used as a cough provocation test for decades. However, the methods of administration have not been standardized. Inhaled mannitol is a novel cough provocation test, which has regulatory approval and can be performed utilizing a simple disposable inhaler in a standardized manner.To compare the mannitol and citric acid cough provocation tests with respect to their ability to identify subjects with chronic cough (...) and their tolerability.Subjects with chronic cough (n = 36) and controls (n = 25) performed provocation tests with mannitol and citric acid. Both tests were video recorded. Cough sensitivity was expressed as coughs-to-dose ratios (CDR) and the cumulative doses to mannitol or concentration to citric acid evoking 5 coughs (C5). Forced expiratory volume in 1 s (FEV1), visual analogue scales (VAS), test completion rates and the total cough frequencies were analysed.Mannitol and citric acid CDR both effectively separated those

2019 Respiratory medicine

137. The evaluation ofefficacy and safety of Cough (EMA) granules used for upper respiratory disorders. (Abstract)

The evaluation ofefficacy and safety of Cough (EMA) granules used for upper respiratory disorders. Ivy leaf is used for the treatment of respiratory diseases with the intensive mucus formation, respiratory infections, and irritating cough coming from the common cold. Conferring to clinical trials, the efficacy, and tolerability of ivy leaf is good. The main compounds accountable for biological activity are triterpene and saponins. Ivy leaves show convulsive/antispasmodic, anti-inflammatory (...) , antimicrobial, analgesic, anthelmintic and anti-thrombin activity. Not only ivy but also marshmallow and mustard seeds are used for these indications. This study was conducted to evaluate the efficacy and safety of Cough (EMA; European Medicines Agency) granules used for upper respiratory disorders. This clinical trial was conducted on 150 patients, out of which 75received the Cough (EMA) granules and 75received the placebo. The age range of patients was 3 years to above 15 years. The sample paired t-test

2019 Pakistan journal of pharmaceutical sciences Controlled trial quality: uncertain

138. Efficacy of Single-Dose Dexmedetomidine Combined with Low-Dose Remifentanil Infusion for Cough Suppression Compared to High-Dose Remifentanil Infusion: A Randomized, Controlled, Non-Inferiority Trial. (Full text)

Efficacy of Single-Dose Dexmedetomidine Combined with Low-Dose Remifentanil Infusion for Cough Suppression Compared to High-Dose Remifentanil Infusion: A Randomized, Controlled, Non-Inferiority Trial. Background: Combination of dexmedetomidine and opioid may be an alternative to high-dose opioid in attenuating cough during emergence from anesthesia, while also reducing the adverse effects of high-dose opioid. We tested the hypothesis that a single-dose of dexmedetomidine combined with low-dose (...) remifentanil infusion during emergence would not be inferior to high-dose remifentanil infusion alone in attenuating cough after thyroidectomy. Methods: One hundred sixty-nine patients undergoing thyroidectomy were enrolled and randomized in a 1:1 ratio into group DR or group R. Each patient received an infusion of dexmedetomidine (0.5 μg/kg) and low-dose remifentanil infusion of effect-site concentration (Ce) at 1 ng/mL or normal saline and high-dose remifentanil infusion of Ce at 2 ng/mL for 10 min

2019 International journal of medical sciences Controlled trial quality: uncertain PubMed abstract

139. Optimal dose of ropivacaine for relieving cough-pain after video-assisted thoracoscopic lobectomy by single intrapleural injection: A randomized, double-blind, controlled study. (Abstract)

Optimal dose of ropivacaine for relieving cough-pain after video-assisted thoracoscopic lobectomy by single intrapleural injection: A randomized, double-blind, controlled study. Pain due to coughing after thoracoscopic surgery remains a clinical problem, and its relief by intrapleural analgesia has not been extensively studied. This study attempts to determine the suitable volume of 0.75% ropivacaine needed for intrapleural analgesia after thoracoscopic surgery.A double-blind, randomized (...) , controlled trial was performed. Forty-five patients were randomly divided into three groups: R20, R15, and R10 (n = 15); 20 ml, 15 ml, or 10 ml of 0.75% ropivacaine was injected into the pleural cavity of each patient in the 3 groups, respectively, when the pain score from postoperative coughing was ≥4. The primary outcome was pain score upon coughing (C-NRS), and the secondary outcomes were pain score at rest (R-NRS), morphine consumption, time of onset, and duration of intrapleural analgesia.All

2019 International journal of surgery (London, England) Controlled trial quality: predicted high

140. Effect of pregabalin for the treatment of chronic refractory cough: A case report. (Full text)

Effect of pregabalin for the treatment of chronic refractory cough: A case report. Chronic refractory cough (CRC) is a common clinical problem which is more likely associated with some physical problems. Although many patients have received satisfactory treatment, there were still many patients suffered from long-term cough symptoms after standardized treatment.A patient suffered from postherpetic neuralgia (PHN) and also he complained CRC for more than 20 years.The patient was diagnosed

2019 Medicine PubMed abstract

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