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101. Cohort study: Pertussis has low prevalence in adults with acute cough and is difficult to distinguish clinically from other causes

Cohort study: Pertussis has low prevalence in adults with acute cough and is difficult to distinguish clinically from other causes Pertussis has low prevalence in adults with acute cough and is difficult to distinguish clinically from other causes | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log (...) in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Pertussis has low prevalence in adults with acute cough and is difficult to distinguish clinically from other causes Article Text Diagnosis

2016 Evidence-Based Medicine

102. Cohort study: Pertussis: a significant cause of prolonged acute cough in previously vaccinated school-aged children Full Text available with Trip Pro

Cohort study: Pertussis: a significant cause of prolonged acute cough in previously vaccinated school-aged children Pertussis: a significant cause of prolonged acute cough in previously vaccinated school-aged children | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password (...) For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Pertussis: a significant cause of prolonged acute cough in previously vaccinated school-aged children Article Text Aetiology/Harm Cohort study Pertussis: a significant cause

2015 Evidence-Based Medicine

103. Tools for Assessing Outcomes in Studies of Chronic Cough

Tools for Assessing Outcomes in Studies of Chronic Cough 804 Evidence-Based Medicine [ 147#3 CHEST MARCH 2015 ] T o o l s f o r A s s essin g Ou t co m es in S t udies o f Chr o nic Cough CHEST Guideline and Expert Panel Report Louis-Philippe Boulet , MD, FCCP ; Remy R. Coeytaux , MD, PhD ; Douglas C. McCrory , MD, MHS ; Cynthia T. French , PhD, RN, FCCP ; Anne B. Chang , MBBS, PhD, MPH ; Surinder S. Birring , MBChB, MD ; Jaclyn Smith , MBChB, PhD ; Rebecca L. Diekemper , MPH ; Bruce Rubin , MD (...) , MEngr, MBA ; and Richard S. Irwin , MD, Master FCCP ; on behalf of the CHEST Expert Cough Panel BACKGROUND: Since the publication of the 2006 American College of Chest Physicians (CHEST) cough guidelines, a variety of tools has been developed or further refi ned for assessing cough. Th e purpose of the present committee was to evaluate instruments used by investigators perform- ing clinical research on chronic cough. Th e specifi c aims were to (1) assess the performance of tools designed to measure

2015 American College of Chest Physicians

104. Inhaled corticosteroids for subacute and chronic cough in adults. Full Text available with Trip Pro

Inhaled corticosteroids for subacute and chronic cough in adults. Persistent cough is a common clinical problem. Despite thorough investigation and empirical management, a considerable proportion of those people with subacute and chronic cough have unexplained cough, for which treatment options are limited. While current guidelines recommend inhaled corticosteroids (ICS), the research evidence for this intervention is conflicting.To assess the effects of ICS for subacute and chronic cough (...) in adults.We searched the Cochrane Airways Group Register of Trials, Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE and ClinicalTrials.gov in December 2012 and conducted handsearches.Two authors independently assessed all potentially relevant trials. All published and unpublished randomised comparisons of ICS versus placebo in adults with subacute or chronic cough were included. Participants with known chronic respiratory disease and asthma were excluded. Studies of cough-variant asthma

2013 Cochrane

105. Systematic review: There is no good evidence for the effectiveness of commonly used over-the-counter medicine to alleviate acute cough

Systematic review: There is no good evidence for the effectiveness of commonly used over-the-counter medicine to alleviate acute cough There is no good evidence for the effectiveness of commonly used over-the-counter medicine to alleviate acute cough | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log (...) in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here There is no good evidence for the effectiveness of commonly used over-the-counter medicine to alleviate acute cough Article Text

2015 Evidence-Based Medicine

106. Codeine for cough and cold: restricted use in children

Codeine for cough and cold: restricted use in children Codeine for cough and cold: restricted use in children - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Codeine for cough and cold: restricted use in children Do not use codeine in children under 12 as it is associated with a risk of respiratory side effects. Codeine is not recommended for adolescents (12 to 18) who have problems with breathing. Published 29 April 2015 From: Therapeutic area: , , Contents When prescribing (...) or dispensing codeine-containing medicines for cough and cold, consider that: codeine is contraindicated in children younger than 12 years old patients of any age known to be CYP2D6 ultra-rapid metabolisers breastfeeding mothers codeine is not recommended for adolescents (12 to 18) who have problems with breathing reporting suspected side effects to codeine or any other medicine on a contributes to our understanding of medicine safety Codeine is an opioid medicine that is authorised for pain relief

2015 MHRA Drug Safety Update

107. Effect of anti-reflux treatment on gastroesophageal reflux-associated chronic cough: Implications of neurogenic and neutrophilic inflammation. (Abstract)

Effect of anti-reflux treatment on gastroesophageal reflux-associated chronic cough: Implications of neurogenic and neutrophilic inflammation. Objective: Gastroesophageal reflux disease (GERD) is an important cause of chronic cough. Substance P (SP) has been implicated in the pathophysiology of cough. Proton pump inhibitors (PPIs) and prokinetic agents are the current treatment for GER-associated cough. The aim was to evaluate the effects of anti-reflux treatment and its associations (...) with cellular and neurogenic inflammation. Methods: Thirty-seven patients with GER-associated cough suspected based on characteristic symptoms such as heartburn and worsening of cough by phonation and rising were recruited. A PPI, rabeprazole 20 mg daily, and a prokinetic agent, itopride 50 mg t.i.d., were administered for 4 weeks in a prospective, observational manner. Before and after treatment, subjective cough measures [visual analog scale (VAS) and the Japanese version of the Leicester Cough

2019 Journal of Asthma

108. Optimal dose of ropivacaine for relieving cough-pain after video-assisted thoracoscopic lobectomy by single intrapleural injection: A randomized, double-blind, controlled study. (Abstract)

Optimal dose of ropivacaine for relieving cough-pain after video-assisted thoracoscopic lobectomy by single intrapleural injection: A randomized, double-blind, controlled study. Pain due to coughing after thoracoscopic surgery remains a clinical problem, and its relief by intrapleural analgesia has not been extensively studied. This study attempts to determine the suitable volume of 0.75% ropivacaine needed for intrapleural analgesia after thoracoscopic surgery.A double-blind, randomized (...) , controlled trial was performed. Forty-five patients were randomly divided into three groups: R20, R15, and R10 (n = 15); 20 ml, 15 ml, or 10 ml of 0.75% ropivacaine was injected into the pleural cavity of each patient in the 3 groups, respectively, when the pain score from postoperative coughing was ≥4. The primary outcome was pain score upon coughing (C-NRS), and the secondary outcomes were pain score at rest (R-NRS), morphine consumption, time of onset, and duration of intrapleural analgesia.All

2019 International journal of surgery (London, England) Controlled trial quality: predicted high

109. Salso-bromo-iodine thermal water: a nonpharmacological alternative treatment for postnasal drip-related cough in children with upper respiratory tract infections. (Abstract)

Salso-bromo-iodine thermal water: a nonpharmacological alternative treatment for postnasal drip-related cough in children with upper respiratory tract infections. Postnasal drip (PND)-related cough is a very common symptom in patients with upper respiratory tract infections (URTIs). At present, there is not a standard treatment for postnasal drip and postnasal drip-related cough. The aim of this pilot study was to evaluate the efficacy of a specific salso-bromo-iodine thermal water containing (...) hyaluronic acid and grapefruit seed extract (SBI-H-GSE) comparing it with a normal saline solution in children with URTIs who refer PND-related symptoms. The study was randomized, single-blind, and controlled. Study group (75 children) was treated with SBI-H-GSE and control group (65 children) was treated with a normal saline solution; both compounds were administered by nasal nebulization with Rinowash nasal douche twice/day for 10 days a month for 3 consecutive months. Parent Cough-Specific Quality

2019 Journal of biological regulators and homeostatic agents Controlled trial quality: uncertain

110. Transmission of bacteria in bronchiectasis and chronic obstructive pulmonary disease: Low burden of cough aerosols. Full Text available with Trip Pro

Transmission of bacteria in bronchiectasis and chronic obstructive pulmonary disease: Low burden of cough aerosols. Aerosol transmission of Pseudomonas aeruginosa has been suggested as a possible mode of respiratory infection spread in patients with cystic fibrosis (CF); however, whether this occurs in other suppurative lung diseases is unknown. Therefore, we aimed to determine if (i) patients with bronchiectasis (unrelated to CF) or chronic obstructive pulmonary disease (COPD) can aerosolize P (...) . aeruginosa during coughing and (ii) if genetically indistinguishable (shared) P. aeruginosa strains are present in these disease cohorts.People with bronchiectasis or COPD and P. aeruginosa respiratory infection were recruited for two studies. Aerosol study: Participants (n = 20) underwent cough testing using validated cough rigs to determine the survival of P. aeruginosa aerosols in the air over distance and duration. Genotyping study: P. aeruginosa sputum isolates (n = 95) were genotyped using

2019 Respirology

111. Cohort Study on Laryngeal Cough Reflex, Respiratory Disease, and Death: A Mediation Analysis. (Abstract)

Cohort Study on Laryngeal Cough Reflex, Respiratory Disease, and Death: A Mediation Analysis. To estimate quantitatively whether the presence of cough associated with dysphagia (laryngeal cough reflex) increased mortality through respiratory disease among community-dwelling older Japanese.A 6-year follow-up prospective cohort study (from 2010 to 2017).Thirteen municipalities in Japan.Community-dwelling individuals aged 65 years or older (N = 32,682).The baseline survey was conducted through (...) self-reported questionnaire. Exposure was experience of laryngeal cough reflex while drinking. The outcome was all-cause mortality. All covariates were selected from demographic, socioeconomic variables, baseline health and functional status, smoking, alcohol drinking, number of remaining teeth, and stroke. The mediator variable was respiratory disease. Cox proportional hazards regression was used to estimate hazard ratios (HRs) for mortality. Parametric mediation analysis was conducted to estimate

2019 Journal of the American Medical Directors Association

112. Effects of intravenous infusion of lidocaine and dexmedetomidine on inhibiting cough during the tracheal extubation period after thyroid surgery. Full Text available with Trip Pro

Effects of intravenous infusion of lidocaine and dexmedetomidine on inhibiting cough during the tracheal extubation period after thyroid surgery. Intravenous lidocaine and dexmedetomidine treatments have been proposed as methods for inhibiting cough. We compared the efficacy of intravenous lidocaine and dexmedetomidine treatments on inhibiting cough during the tracheal extubation period after thyroid surgery.One hundred eighty patients undergoing thyroid surgeries were randomly allocated (...) to the LIDO group (received lidocaine 1.5 mg/kg loading, 1.5 mg/kg/h infusion), the DEX group (received dexmedetomidine 0.5 μg/kg loading, 0.4 μg/kg/h infusion) and the CON group (received saline), with 60 cases in each group. The primary outcomes of cough were recorded. Secondary outcomes included hemodynamic variables, awareness time, volume of drainage, the postoperative visual analogue scale and adverse effects were recorded.The incidence of cough were significantly lower in the LIDO group (28.3

2019 BMC Anesthesiology Controlled trial quality: uncertain

113. Effect of pregabalin for the treatment of chronic refractory cough: A case report. Full Text available with Trip Pro

Effect of pregabalin for the treatment of chronic refractory cough: A case report. Chronic refractory cough (CRC) is a common clinical problem which is more likely associated with some physical problems. Although many patients have received satisfactory treatment, there were still many patients suffered from long-term cough symptoms after standardized treatment.A patient suffered from postherpetic neuralgia (PHN) and also he complained CRC for more than 20 years.The patient was diagnosed

2019 Medicine

114. A prospective multicentre study testing the diagnostic accuracy of an automated cough sound centred analytic system for the identification of common respiratory disorders in children. Full Text available with Trip Pro

A prospective multicentre study testing the diagnostic accuracy of an automated cough sound centred analytic system for the identification of common respiratory disorders in children. The differential diagnosis of paediatric respiratory conditions is difficult and suboptimal. Existing diagnostic algorithms are associated with significant error rates, resulting in misdiagnoses, inappropriate use of antibiotics and unacceptable morbidity and mortality. Recent advances in acoustic engineering (...) and artificial intelligence have shown promise in the identification of respiratory conditions based on sound analysis, reducing dependence on diagnostic support services and clinical expertise. We present the results of a diagnostic accuracy study for paediatric respiratory disease using an automated cough-sound analyser.We recorded cough sounds in typical clinical environments and the first five coughs were used in analyses. Analyses were performed using cough data and up to five-symptom input derived from

2019 Respiratory research

115. Bradykinin sensitizes the cough reflex via a B<sub>2</sub> receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase. Full Text available with Trip Pro

Bradykinin sensitizes the cough reflex via a B2 receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase. Inhaled bradykinin (BK) has been reported to both sensitize and induce cough but whether BK can centrally sensitize the cough reflex is not fully established. In this study, using a conscious guinea-pig model of cough, we investigated the role of BK in the central sensitization of the cough reflex and in airway (...) obstruction.Drugs were administered, to guinea pigs, by the intracerebroventricular (i.c.v.) route. Aerosolized citric acid (0.2 M) was used to induce cough in a whole-body plethysmograph box, following i.c.v. infusion of drugs. An automated analyser recorded both cough and airway obstruction simultaneously.BK, administered by the i.c.v. route, dose-dependently enhanced the citric acid-induced cough and airway obstruction. This effect was inhibited following i.c.v. pretreatment with a B2 receptor antagonist

2019 Respiratory research

116. Chronic Cough in a 70-Year-Old Woman. Full Text available with Trip Pro

Chronic Cough in a 70-Year-Old Woman. A 70-year-old lifelong nonsmoking woman with a past medical history of hypertension was referred to the respiratory clinic for evaluation of chronic cough. She presented with a 5-month history of dry cough, night sweats, fatigue, and a 4.5-kg weight loss. Her cough tended to be worse while lying flat. She denied having shortness of breath, chest pain, wheeze, or hemoptysis. She was taking amlodipine for her blood pressure as well as omeprazole

2019 Chest

117. Altered neural activity in brain cough suppression networks in cigarette smokers. (Abstract)

Altered neural activity in brain cough suppression networks in cigarette smokers. Cough is important for airway defence and studies in healthy animals and humans have revealed multiple brain networks intimately involved in the perception of airway irritation, cough induction and cough suppression. Changes in cough sensitivity and/ or the ability to suppress cough accompany pulmonary pathologies, suggesting a level of plasticity is possible in these central neural circuits. However, little (...) is known about how persistent inputs from the lung might modify the brain processes regulating cough. In the present study, we used human functional brain imaging to investigate the central neural responses that accompany an altered cough sensitivity in cigarette smokers. In non-smokers, inhalation of the airway irritant capsaicin induced a transient urge-to-cough associated with the activation of a distributed brain network that included sensory, prefrontal and motor cortical regions. Cigarette

2019 European Respiratory Journal

118. Relationship of vocal fold atrophy to swallowing safety and cough function in Parkinson's disease. (Abstract)

Relationship of vocal fold atrophy to swallowing safety and cough function in Parkinson's disease. When swallowing function is compromised in patients with Parkinson's disease (PD), cough plays a crucial role in clearing the airway and preventing pulmonary complications. The aim of this study was to determine the influence of vocal fold atrophy severity as measured by the bowing index (BI) on airway protection in PD.Thirty participants with PD completed measures of voluntary and reflex cough (...) . Flexible laryngoscopy with endoscopic evaluation of swallowing allowed for measurement of BI using ImageJ software. Swallowing safety was scored on the Penetration-Aspiration Scale (PAS). Regression and receiver operating characteristic (ROC) analyses were performed to test our study aim.Twenty-four of 30 participants had some degree of vocal fold atrophy (BI >0). When controlling for age, disease duration did not significantly influence BI. BI was not predictive of any sensorimotor parameters of cough

2019 Laryngoscope

119. Are neural pathways processing airway inputs sensitized in patients with cough hypersensitivity? (Abstract)

Are neural pathways processing airway inputs sensitized in patients with cough hypersensitivity? Patients with cough hypersensitivity exhibit unusually low thresholds for responses to tussive stimuli, exaggerated responses to suprathreshold tussive stimuli, and report spontaneous experiences of urge-to-cough in the absence of exogenous stimulation. These aberrant responses to tussive challenge have the hallmark features of behaviours associated with a sensitized sensory system. Searching (...) for further evidence to implicate neural sensitization in the symptomatology of cough hypersensitivity warrants consideration. If up-regulation of neural circuits involved in processing of airways inputs can be demonstrated in patients with cough hypersensitivity, then strategies to reverse this dysfunctional plasticity can be contemplated and assessed. This review considers the implications of neural sensitization as a factor in the cough hypersensitivity syndrome, reflects on the limited data available

2019 Pulmonary Pharmacology & Therapeutics

120. Bronchiectasis and cough: An old relationship in need of renewed attention. (Abstract)

Bronchiectasis and cough: An old relationship in need of renewed attention. Bronchiectasis is an increasingly recognised respiratory condition with limited therapeutic options and a complex spectrum of clinical manifestations that invariably includes chronic cough. As the primary presentation of bronchiectasis in most cases, chronic cough and its mechanistic underpinnings are of central importance but remain poorly understood in this setting. Bronchiectasis is also increasingly identified (...) as an underlying cause of chronic cough highlighting the interrelationship between the two conditions that share overlapping clinical features. Several therapeutic approaches have illustrated positive effects on bronchiectasis-associated cough, however, more focused treatment of heterogeneous cough subtypes may yield better outcomes for patients. A current challenge is the identification of bronchiectasis and cough endophenotypes that may allow improved patient stratification and more targeted therapeutic

2019 Pulmonary Pharmacology & Therapeutics

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