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101. Psychological profile of individuals presenting with chronic cough Full Text available with Trip Pro

Psychological profile of individuals presenting with chronic cough Chronic refractory cough (CRC) is a common problem in respiratory clinics. Adverse effects on quality of life are documented in the literature, but relatively little is known about the underlying psychological factors in this patient population. We aimed to investigate the association of psychological factors with chronic cough, comparing CRC to explained cough and non-cough groups. 67 patients attending a specialist cough (...) clinic (CRC, n=25; explained cough, n=42) and 22 non-cough individuals participated. All participants completed the Hospital Anxiety & Depression Scale, Big Five Inventory (Personality), Chalder Fatigue Scale and Patient Health Questionnaire-15. Cough patients also completed the Illness Perception Questionnaire-Revised. Appropriate statistical analyses were used to compare participant groups. Chronic refractory coughers displayed significantly higher levels of anxiety, depression, fatigue and somatic

2017 ERJ open research

102. Treatment of Unexplained Chronic Cough

Treatment of Unexplained Chronic Cough Treatment of Unexplained Chronic Cough CHEST Guideline and Expert Panel Report Peter Gibson, MBBS; Gang Wang, MD, PhD; Lorcan McGarvey, MD; Anne E. Vertigan, PhD, MBA, BAppSc (SpPath); Kenneth W. Altman, MD, PhD; and Surinder S. Birring, MB ChB, MD; on behalf of the CHEST Expert Cough Panel BACKGROUND: Unexplained chronic cough (UCC) causes signi?cant impairments in quality of life. Effective assessment and treatment approaches are needed for UCC. METHODS (...) : This systematic review of randomized controlled trials (RCTs) asked: What is the ef?cacy of treatment compared with usual care for cough severity, cough frequency, and cough-related quality of life in patients with UCC? Studies of adults and adolescents aged> 12 years with a chronic cough of> 8 weeks’ duration that was unexplained after systematic investigation and treatment were included and assessed for relevance and quality. Based on the systematic review, guideline suggestions were developed and voted

2016 American College of Chest Physicians

103. Occupational and Environmental Contributions to Chronic Cough in Adults

Occupational and Environmental Contributions to Chronic Cough in Adults Occupational and Environmental Contributions to Chronic Cough in Adults Chest Expert Panel Report Susan M. Tarlo, MBBS, FCCP; Kenneth W. Altman, MD, PhD; John Oppenheimer, MD; Kaiser Lim, MD; Anne Vertigan, PhD; David Prezant, MD; and Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel BACKGROUND: In response to occupational and environmental exposures, cough can be an isolatedsymptomre?ecting (...) exposuretoanirritantwithlittlephysiologicalconsequence,orit can be a manifestation of more signi?cant disease. This document reviews occupational and environmental contributions to chronic cough in adults, focusing on aspects not previously covered in the 2006 ACCP Cough Guideline or our more recent systematic review, and suggests an approach to investigation of these factors when suspected. METHODS: MEDLINE and TOXLINE literature searches were supplemented by articles identi?edbythecoughpaneloccupationalandenvironmentalsubgroupmembers,toidentify

2016 American College of Chest Physicians

104. Chronic Cough Due to Gastroesophageal Reflux in Adults

Chronic Cough Due to Gastroesophageal Reflux in Adults Chronic Cough Due to Gastroesophageal Re?ux in Adults CHEST Guideline and Expert Panel Report Peter J. Kahrilas, MD; Kenneth W. Altman, MD, PhD; Anne B. Chang, PhD; Stephen K. Field, MD, FCCP; Susan M. Harding, MD, FCCP; Andrew P. Lane, MD; Kaiser Lim, MD, FCCP; Lorcan McGarvey, MD; Jaclyn Smith, PhD; and Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel BACKGROUND: We updated the 2006 ACCP clinical practice (...) guidelines for management of re?ux-cough syndrome. METHODS: Two population, intervention, comparison, outcome (PICO) questions were addressed by systematic review: (1) Can therapy for gastroesophageal re?ux improve or eliminatecoughinadultswithchronicandpersistentlytroublesomecough?and(2)Arethere minimal clinical criteria to guide practice in determining that chronic cough is likely to respond to therapy for gastroesophageal re?ux? RESULTS: We found no high-quality studies pertinent to either question

2016 American College of Chest Physicians

105. Cohort study: Pertussis has low prevalence in adults with acute cough and is difficult to distinguish clinically from other causes

Cohort study: Pertussis has low prevalence in adults with acute cough and is difficult to distinguish clinically from other causes Pertussis has low prevalence in adults with acute cough and is difficult to distinguish clinically from other causes | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log (...) in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Pertussis has low prevalence in adults with acute cough and is difficult to distinguish clinically from other causes Article Text Diagnosis

2016 Evidence-Based Medicine

106. Cohort study: Pertussis: a significant cause of prolonged acute cough in previously vaccinated school-aged children Full Text available with Trip Pro

Cohort study: Pertussis: a significant cause of prolonged acute cough in previously vaccinated school-aged children Pertussis: a significant cause of prolonged acute cough in previously vaccinated school-aged children | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password (...) For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Pertussis: a significant cause of prolonged acute cough in previously vaccinated school-aged children Article Text Aetiology/Harm Cohort study Pertussis: a significant cause

2015 Evidence-Based Medicine

107. Tools for Assessing Outcomes in Studies of Chronic Cough

Tools for Assessing Outcomes in Studies of Chronic Cough 804 Evidence-Based Medicine [ 147#3 CHEST MARCH 2015 ] T o o l s f o r A s s essin g Ou t co m es in S t udies o f Chr o nic Cough CHEST Guideline and Expert Panel Report Louis-Philippe Boulet , MD, FCCP ; Remy R. Coeytaux , MD, PhD ; Douglas C. McCrory , MD, MHS ; Cynthia T. French , PhD, RN, FCCP ; Anne B. Chang , MBBS, PhD, MPH ; Surinder S. Birring , MBChB, MD ; Jaclyn Smith , MBChB, PhD ; Rebecca L. Diekemper , MPH ; Bruce Rubin , MD (...) , MEngr, MBA ; and Richard S. Irwin , MD, Master FCCP ; on behalf of the CHEST Expert Cough Panel BACKGROUND: Since the publication of the 2006 American College of Chest Physicians (CHEST) cough guidelines, a variety of tools has been developed or further refi ned for assessing cough. Th e purpose of the present committee was to evaluate instruments used by investigators perform- ing clinical research on chronic cough. Th e specifi c aims were to (1) assess the performance of tools designed to measure

2015 American College of Chest Physicians

108. Systematic review: There is no good evidence for the effectiveness of commonly used over-the-counter medicine to alleviate acute cough

Systematic review: There is no good evidence for the effectiveness of commonly used over-the-counter medicine to alleviate acute cough There is no good evidence for the effectiveness of commonly used over-the-counter medicine to alleviate acute cough | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log (...) in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here There is no good evidence for the effectiveness of commonly used over-the-counter medicine to alleviate acute cough Article Text

2015 Evidence-Based Medicine

109. Codeine for cough and cold: restricted use in children

Codeine for cough and cold: restricted use in children Codeine for cough and cold: restricted use in children - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Codeine for cough and cold: restricted use in children Do not use codeine in children under 12 as it is associated with a risk of respiratory side effects. Codeine is not recommended for adolescents (12 to 18) who have problems with breathing. Published 29 April 2015 From: Therapeutic area: , , Contents When prescribing (...) or dispensing codeine-containing medicines for cough and cold, consider that: codeine is contraindicated in children younger than 12 years old patients of any age known to be CYP2D6 ultra-rapid metabolisers breastfeeding mothers codeine is not recommended for adolescents (12 to 18) who have problems with breathing reporting suspected side effects to codeine or any other medicine on a contributes to our understanding of medicine safety Codeine is an opioid medicine that is authorised for pain relief

2015 MHRA Drug Safety Update

110. Effect of anti-reflux treatment on gastroesophageal reflux-associated chronic cough: Implications of neurogenic and neutrophilic inflammation. (Abstract)

Effect of anti-reflux treatment on gastroesophageal reflux-associated chronic cough: Implications of neurogenic and neutrophilic inflammation. Objective: Gastroesophageal reflux disease (GERD) is an important cause of chronic cough. Substance P (SP) has been implicated in the pathophysiology of cough. Proton pump inhibitors (PPIs) and prokinetic agents are the current treatment for GER-associated cough. The aim was to evaluate the effects of anti-reflux treatment and its associations (...) with cellular and neurogenic inflammation. Methods: Thirty-seven patients with GER-associated cough suspected based on characteristic symptoms such as heartburn and worsening of cough by phonation and rising were recruited. A PPI, rabeprazole 20 mg daily, and a prokinetic agent, itopride 50 mg t.i.d., were administered for 4 weeks in a prospective, observational manner. Before and after treatment, subjective cough measures [visual analog scale (VAS) and the Japanese version of the Leicester Cough

2019 Journal of Asthma

111. Optimal dose of ropivacaine for relieving cough-pain after video-assisted thoracoscopic lobectomy by single intrapleural injection: A randomized, double-blind, controlled study. (Abstract)

Optimal dose of ropivacaine for relieving cough-pain after video-assisted thoracoscopic lobectomy by single intrapleural injection: A randomized, double-blind, controlled study. Pain due to coughing after thoracoscopic surgery remains a clinical problem, and its relief by intrapleural analgesia has not been extensively studied. This study attempts to determine the suitable volume of 0.75% ropivacaine needed for intrapleural analgesia after thoracoscopic surgery.A double-blind, randomized (...) , controlled trial was performed. Forty-five patients were randomly divided into three groups: R20, R15, and R10 (n = 15); 20 ml, 15 ml, or 10 ml of 0.75% ropivacaine was injected into the pleural cavity of each patient in the 3 groups, respectively, when the pain score from postoperative coughing was ≥4. The primary outcome was pain score upon coughing (C-NRS), and the secondary outcomes were pain score at rest (R-NRS), morphine consumption, time of onset, and duration of intrapleural analgesia.All

2019 International journal of surgery (London, England) Controlled trial quality: predicted high

112. Salso-bromo-iodine thermal water: a nonpharmacological alternative treatment for postnasal drip-related cough in children with upper respiratory tract infections. (Abstract)

Salso-bromo-iodine thermal water: a nonpharmacological alternative treatment for postnasal drip-related cough in children with upper respiratory tract infections. Postnasal drip (PND)-related cough is a very common symptom in patients with upper respiratory tract infections (URTIs). At present, there is not a standard treatment for postnasal drip and postnasal drip-related cough. The aim of this pilot study was to evaluate the efficacy of a specific salso-bromo-iodine thermal water containing (...) hyaluronic acid and grapefruit seed extract (SBI-H-GSE) comparing it with a normal saline solution in children with URTIs who refer PND-related symptoms. The study was randomized, single-blind, and controlled. Study group (75 children) was treated with SBI-H-GSE and control group (65 children) was treated with a normal saline solution; both compounds were administered by nasal nebulization with Rinowash nasal douche twice/day for 10 days a month for 3 consecutive months. Parent Cough-Specific Quality

2019 Journal of biological regulators and homeostatic agents Controlled trial quality: uncertain

113. Transmission of bacteria in bronchiectasis and chronic obstructive pulmonary disease: Low burden of cough aerosols. Full Text available with Trip Pro

Transmission of bacteria in bronchiectasis and chronic obstructive pulmonary disease: Low burden of cough aerosols. Aerosol transmission of Pseudomonas aeruginosa has been suggested as a possible mode of respiratory infection spread in patients with cystic fibrosis (CF); however, whether this occurs in other suppurative lung diseases is unknown. Therefore, we aimed to determine if (i) patients with bronchiectasis (unrelated to CF) or chronic obstructive pulmonary disease (COPD) can aerosolize P (...) . aeruginosa during coughing and (ii) if genetically indistinguishable (shared) P. aeruginosa strains are present in these disease cohorts.People with bronchiectasis or COPD and P. aeruginosa respiratory infection were recruited for two studies. Aerosol study: Participants (n = 20) underwent cough testing using validated cough rigs to determine the survival of P. aeruginosa aerosols in the air over distance and duration. Genotyping study: P. aeruginosa sputum isolates (n = 95) were genotyped using

2019 Respirology

114. Cohort Study on Laryngeal Cough Reflex, Respiratory Disease, and Death: A Mediation Analysis. (Abstract)

Cohort Study on Laryngeal Cough Reflex, Respiratory Disease, and Death: A Mediation Analysis. To estimate quantitatively whether the presence of cough associated with dysphagia (laryngeal cough reflex) increased mortality through respiratory disease among community-dwelling older Japanese.A 6-year follow-up prospective cohort study (from 2010 to 2017).Thirteen municipalities in Japan.Community-dwelling individuals aged 65 years or older (N = 32,682).The baseline survey was conducted through (...) self-reported questionnaire. Exposure was experience of laryngeal cough reflex while drinking. The outcome was all-cause mortality. All covariates were selected from demographic, socioeconomic variables, baseline health and functional status, smoking, alcohol drinking, number of remaining teeth, and stroke. The mediator variable was respiratory disease. Cox proportional hazards regression was used to estimate hazard ratios (HRs) for mortality. Parametric mediation analysis was conducted to estimate

2019 Journal of the American Medical Directors Association

115. Effects of intravenous infusion of lidocaine and dexmedetomidine on inhibiting cough during the tracheal extubation period after thyroid surgery. Full Text available with Trip Pro

Effects of intravenous infusion of lidocaine and dexmedetomidine on inhibiting cough during the tracheal extubation period after thyroid surgery. Intravenous lidocaine and dexmedetomidine treatments have been proposed as methods for inhibiting cough. We compared the efficacy of intravenous lidocaine and dexmedetomidine treatments on inhibiting cough during the tracheal extubation period after thyroid surgery.One hundred eighty patients undergoing thyroid surgeries were randomly allocated (...) to the LIDO group (received lidocaine 1.5 mg/kg loading, 1.5 mg/kg/h infusion), the DEX group (received dexmedetomidine 0.5 μg/kg loading, 0.4 μg/kg/h infusion) and the CON group (received saline), with 60 cases in each group. The primary outcomes of cough were recorded. Secondary outcomes included hemodynamic variables, awareness time, volume of drainage, the postoperative visual analogue scale and adverse effects were recorded.The incidence of cough were significantly lower in the LIDO group (28.3

2019 BMC Anesthesiology Controlled trial quality: uncertain

116. Effect of pregabalin for the treatment of chronic refractory cough: A case report. Full Text available with Trip Pro

Effect of pregabalin for the treatment of chronic refractory cough: A case report. Chronic refractory cough (CRC) is a common clinical problem which is more likely associated with some physical problems. Although many patients have received satisfactory treatment, there were still many patients suffered from long-term cough symptoms after standardized treatment.A patient suffered from postherpetic neuralgia (PHN) and also he complained CRC for more than 20 years.The patient was diagnosed

2019 Medicine

117. A prospective multicentre study testing the diagnostic accuracy of an automated cough sound centred analytic system for the identification of common respiratory disorders in children. Full Text available with Trip Pro

A prospective multicentre study testing the diagnostic accuracy of an automated cough sound centred analytic system for the identification of common respiratory disorders in children. The differential diagnosis of paediatric respiratory conditions is difficult and suboptimal. Existing diagnostic algorithms are associated with significant error rates, resulting in misdiagnoses, inappropriate use of antibiotics and unacceptable morbidity and mortality. Recent advances in acoustic engineering (...) and artificial intelligence have shown promise in the identification of respiratory conditions based on sound analysis, reducing dependence on diagnostic support services and clinical expertise. We present the results of a diagnostic accuracy study for paediatric respiratory disease using an automated cough-sound analyser.We recorded cough sounds in typical clinical environments and the first five coughs were used in analyses. Analyses were performed using cough data and up to five-symptom input derived from

2019 Respiratory research

118. Bradykinin sensitizes the cough reflex via a B<sub>2</sub> receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase. Full Text available with Trip Pro

Bradykinin sensitizes the cough reflex via a B2 receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase. Inhaled bradykinin (BK) has been reported to both sensitize and induce cough but whether BK can centrally sensitize the cough reflex is not fully established. In this study, using a conscious guinea-pig model of cough, we investigated the role of BK in the central sensitization of the cough reflex and in airway (...) obstruction.Drugs were administered, to guinea pigs, by the intracerebroventricular (i.c.v.) route. Aerosolized citric acid (0.2 M) was used to induce cough in a whole-body plethysmograph box, following i.c.v. infusion of drugs. An automated analyser recorded both cough and airway obstruction simultaneously.BK, administered by the i.c.v. route, dose-dependently enhanced the citric acid-induced cough and airway obstruction. This effect was inhibited following i.c.v. pretreatment with a B2 receptor antagonist

2019 Respiratory research

119. Chronic Cough in a 70-Year-Old Woman. Full Text available with Trip Pro

Chronic Cough in a 70-Year-Old Woman. A 70-year-old lifelong nonsmoking woman with a past medical history of hypertension was referred to the respiratory clinic for evaluation of chronic cough. She presented with a 5-month history of dry cough, night sweats, fatigue, and a 4.5-kg weight loss. Her cough tended to be worse while lying flat. She denied having shortness of breath, chest pain, wheeze, or hemoptysis. She was taking amlodipine for her blood pressure as well as omeprazole

2019 Chest

120. Altered neural activity in brain cough suppression networks in cigarette smokers. (Abstract)

Altered neural activity in brain cough suppression networks in cigarette smokers. Cough is important for airway defence and studies in healthy animals and humans have revealed multiple brain networks intimately involved in the perception of airway irritation, cough induction and cough suppression. Changes in cough sensitivity and/ or the ability to suppress cough accompany pulmonary pathologies, suggesting a level of plasticity is possible in these central neural circuits. However, little (...) is known about how persistent inputs from the lung might modify the brain processes regulating cough. In the present study, we used human functional brain imaging to investigate the central neural responses that accompany an altered cough sensitivity in cigarette smokers. In non-smokers, inhalation of the airway irritant capsaicin induced a transient urge-to-cough associated with the activation of a distributed brain network that included sensory, prefrontal and motor cortical regions. Cigarette

2019 European Respiratory Journal

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