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81. An advanced recording and analysis system for the differentiation of guinea pig cough responses to citric acid and prostaglandin E2 in real time. Full Text available with Trip Pro

An advanced recording and analysis system for the differentiation of guinea pig cough responses to citric acid and prostaglandin E2 in real time. Cough number and/or sound have been used to assess cough sensitivity/intensity and to discriminate cough patterns in clinical settings. However, to date, only manual counting of cough number in an offline manner is applied in animal cough studies, which diminishes the efficiency of cough identification and hinders the diagnostic discrimination (...) of cough patterns, especially in animals with pulmonary diseases. This study aims to validate a novel recording/analysis system by which cough numbers are automatically counted and cough patterns are comprehensively differentiated in real time. The experiment was carried out in conscious guinea pigs exposed to aerosolized citric acid (CA, 150 mM) and prostaglandin E2 (PGE2, 0.43 mM). Animal body posture (video), respiratory flow, and cough acoustics (audio) were simultaneously monitored and recorded

2019 PLoS ONE

82. Treatments for subacute cough in primary care: systematic review and meta-analyses of randomised clinical trials Full Text available with Trip Pro

Treatments for subacute cough in primary care: systematic review and meta-analyses of randomised clinical trials Subacute cough following a non-specific viral infection lasting 3-8 weeks is common. However, despite many treatment options there are no systematic reviews evaluating these.To provide a systematic overview of treatment options and outcomes evaluated in randomised clinical trials (RCTs).Systematic review and meta-analyses assessing the overall effects of any treatment for subacute (...) cough.The authors systematically searched PubMed/MEDLINE and the Cochrane Central Register of Controlled Trials (last search March 2017) for RCTs in adult patients with subacute cough. The authors considered trials evaluating any outcome of any drug or non-drug treatments, apart from traditional Chinese and Asian medicines. They combined treatment effects on cough-related outcomes in random effects meta-analyses.Six eligible RCTs including 724 patients were identified. These assessed montelukast

2018 EvidenceUpdates

83. Treatment of Interstitial Lung Disease Associated Cough: CHEST Guideline and Expert Panel Report Full Text available with Trip Pro

Treatment of Interstitial Lung Disease Associated Cough: CHEST Guideline and Expert Panel Report Chronic cough in interstitial lung disease (ILD) causes significant impairment in quality of life. Effective treatment approaches are needed for cough associated with ILD.This systematic review asked: Is there evidence of clinically relevant treatment effects for therapies for cough in ILD? Studies of adults aged > 18 years with a chronic cough ≥ 8 weeks' duration were included and assessed (...) for relevance and quality. Based on the systematic review, guideline suggestions were developed and voted on by using CHEST guideline methodology.Eight randomized controlled trials and two case series (≥ 10 patients) were included that reported data on patients with idiopathic pulmonary fibrosis, sarcoidosis, and scleroderma-related ILD who received a variety of interventions. Study quality was high in all eight randomized controlled trials. Inhaled corticosteroids were not supported for cough associated

2018 EvidenceUpdates

84. Cough Due to TB and Other Chronic Infections: CHEST Guideline and Expert Panel Report Full Text available with Trip Pro

Cough Due to TB and Other Chronic Infections: CHEST Guideline and Expert Panel Report Cough is common in pulmonary TB and other chronic respiratory infections. Identifying features that predict whether pulmonary TB is the cause would help target appropriate individuals for rapid and cost-effective screening, potentially limiting disease progression and preventing transmission to others.A systematic literature search for individual studies to answer eight key questions (KQs) was conducted (...) according to established Chest Organization methods by using the following databases: MEDLINE via PubMed, Embase, Scopus, and the Cochrane Database of Systematic Reviews from January 1, 1984, to April 2014. Searches for KQ 1 and KQ 3 were updated in February 2016. An updated KQ 2 search was undertaken in March 2017.Even where TB prevalence is greatest, most individuals with cough do not have pulmonary TB. There was no evidence that 1, 3, or 4 weeks' duration were better predictors than cough lasting ≥ 2

2018 EvidenceUpdates

85. Honey for coughs in children with URTI

Honey for coughs in children with URTI RACGP - Honey and cough in children with URTI Search Become a student member today for free and be part of the RACGP community A career in general practice Starting the GP journey Enrolments for the 2019.1 OSCE FRACGP exams closing 29 March 2019 Fellowship FRACGP exams Research Practice Experience Program is a self-directed education program designed to support non vocationally registered doctors on their pathway to RACGP Fellowship Fellowship (...) Media Releases 2013 Media Releases 2012 Media Releases Search Honey and cough in children with URTI Honey and cough in children with URTI Introduction Cough associated with an URTI in children does not require treatment but treatment may be necessary when the cough interferes with sleep. Indication Honey may be used if a cough suppressant is sought for the short-term symptomatic relief of nocturnal cough in children (12 months to 18 years of age) with an URTI after other causes of the cough have

2014 Handbook of Non-Drug interventions (HANDI)

86. Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults. Full Text available with Trip Pro

Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults. Cough is often distressing for patients with pneumonia. Accordingly they often use over-the-counter (OTC) cough medications (mucolytics or cough suppressants). These might provide relief in reducing cough severity, but suppression of the cough mechanism might impede airway clearance and cause harm.To evaluate the efficacy of OTC cough medications as an adjunct (...) to antibiotics in children and adults with pneumonia.We searched CENTRAL 2013, Issue 12, MEDLINE (January 1966 to January week 2, 2014), OLDMEDLINE (1950 to 1965), EMBASE (1980 to January 2014), CINAHL (2009 to January 2014), LILACS (2009 to January 2014) and Web of Science (2009 to January 2014).Randomised controlled trials (RCTs) in children and adults comparing any type of OTC cough medication with placebo, or control medication, with cough as an outcome and where the cough is secondary to acute

2014 Cochrane

87. Acellular vaccines for preventing whooping cough in children. (Abstract)

Acellular vaccines for preventing whooping cough in children. Routine use of whole-cell pertussis (wP) vaccines was suspended in some countries in the 1970s and 1980s because of concerns about adverse effects. Following this action, there was a resurgence of whooping cough. Acellular pertussis (aP) vaccines, containing purified or recombinant Bordetella pertussis (B. pertussis) antigens, were developed in the hope that they would be as effective, but less reactogenic than the whole-cell (...) with a total of 136,541 participants. Most of the safety trials did not report the methods for random sequence generation, allocation concealment and blinding, which made it difficult to assess the risk of bias in the studies. The efficacy of multi-component (≥ three) vaccines varied from 84% to 85% in preventing typical whooping cough (characterised by 21 or more consecutive days of paroxysmal cough with confirmation of B. pertussis infection by culture, appropriate serology or contact with a household

2014 Cochrane

88. Clinical pathways for chronic cough in children. Full Text available with Trip Pro

Clinical pathways for chronic cough in children. Chronic cough (a cough lasting longer than four weeks) is a common problem internationally. Chronic cough has associated economic costs and is distressing to the child and to parents; ignoring cough may lead to delayed diagnosis and progression of serious underlying respiratory disease. Clinical guidelines have been shown to lead to efficient and effective patient care and can facilitate clinical decision making. Cough guidelines have been (...) designed to facilitate the management of chronic cough. However, treatment recommendations vary, and specific clinical pathways for the treatment of chronic cough in children are important, as causes of and treatments for cough vary significantly from those in adults. Therefore, systematic evaluation of the use of evidence-based clinical pathways for the management of chronic cough in children would be beneficial for clinical practice and for patient care. Use of a management algorithm can improve

2014 Cochrane

89. Honey for acute cough in children. Full Text available with Trip Pro

Honey for acute cough in children. Cough causes concern for parents and is a major cause of outpatient visits. It can impact on quality of life, cause anxiety and affect sleep in parents and children. Several remedies, including honey, have been used to alleviate cough symptoms.To evaluate the effectiveness of honey for acute cough in children in ambulatory settings.We searched CENTRAL (2014, Issue 10), MEDLINE (1950 to October week 4, 2014), EMBASE (1990 to November 2014), CINAHL (1981 (...) to November 2014), Web of Science (2000 to November 2014), AMED (1985 to November 2014), LILACS (1982 to November 2014) and CAB abstracts (2009 to January 2014).Randomised controlled trials (RCTs) comparing honey given alone, or in combination with antibiotics, versus nothing, placebo or other over-the-counter (OTC) cough medications to participants aged from one to 18 years for acute cough in ambulatory settings.Two review authors independently screened search results for eligible studies and extracted

2014 Cochrane

90. Over-the-counter (OTC) medications for acute cough in children and adults in community settings. (Abstract)

Over-the-counter (OTC) medications for acute cough in children and adults in community settings. Acute cough due to upper respiratory tract infection (URTI) is a common symptom. Non-prescription, over-the-counter (OTC) medicines are frequently recommended as a first-line treatment, but there is little evidence as to whether these drugs are effective.To assess the effects of oral OTC cough preparations for acute cough in children and adults in community settings.We searched CENTRAL (2014, Issue (...) 1), MEDLINE (January 1966 to March week 3 2014), EMBASE (January 1974 to March 2014), CINAHL (January 2010 to March 2014), LILACS (January 2010 to March 2014), Web of Science (January 2010 to March 2014) and the UK Department of Health National Research Register (March 2010).Randomised controlled trials (RCTs) comparing oral OTC cough preparations with placebo in children and adults suffering from acute cough in community settings. We considered all cough outcomes; secondary outcomes of interest

2014 Cochrane

91. Whooping cough

Whooping cough Whooping cough - NICE CKS Share Whooping cough: Summary Whooping cough, also known as pertussis, is a highly infectious disease caused by the bacterium Bordetella pertussis . It is spread by aerosol droplets released during coughing, and disproportionately affects infants and young children. The name of the infection is derived from the characteristic 'whoops' that occur in younger children, caused by sharp inhalation of breath during bouts of paroxysmal cough. The incubation (...) period of whooping cough is usually about 7 days, and the person is infectious for 3 weeks after the onset of symptoms. Whooping cough has 3 phases of symptoms. The catarrhal phase lasts approximately a week and is characterized by the development of a dry, unproductive cough. The paroxysmal phase may last for a month or more and is characterized by coughing fits, whooping, and post-tussive vomiting. The person may be relatively well between paroxysms. The convalescent phase may last an additional 2

2018 NICE Clinical Knowledge Summaries

92. Mechanical insufflation-exsufflation assisted coughing in neuromuscular diseases

Mechanical insufflation-exsufflation assisted coughing in neuromuscular diseases Mechanical insufflation-exsufflation assisted coughing in neuromuscular diseases Mechanical insufflation-exsufflation assisted coughing in neuromuscular diseases Secco A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Bardach A, Ciapponi A, López A, Rey-Ares L Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality (...) of this assessment has been made for the HTA database. Citation Secco A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Bardach A, Ciapponi A, López A, Rey-Ares L. Mechanical insufflation-exsufflation assisted coughing in neuromuscular diseases. Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Documentos de Evaluación de Tecnologías Sanitarias, Informe de Respuesta Rápida N° 445. 2015 Authors' conclusions The existing evidence on mechanical insufflation-exsufflation

2015 Health Technology Assessment (HTA) Database.

93. Posture and firmness changes in a pressure-relieving air mattress affect cough strength in elderly people with dysphagia. Full Text available with Trip Pro

Posture and firmness changes in a pressure-relieving air mattress affect cough strength in elderly people with dysphagia. Dysphagia is the major pathophysiologic mechanism leading to aspiration pneumonia in the elderly. Elderly people with dysphagia who show low levels of the cough peak flow (CPF) are at greater risk for aspiration pneumonia. It has been reported that CPF values were significantly lower in the "soft" versus "hard" mode of a pressure-relieving air mattress in healthy volunteers (...) in a supine position. Parameters such as spinal curvature, however, were not evaluated in detail. In this study, we clarified whether the changes in posture associated with two different firmness levels of a pressure-relieving air mattress were associated with cough production and related factors in the elderly with dysphagia. The body sinking distance, pelvic tilt angle, and immersion of the lumbar spine were measured to evaluate changes in posture. Forty subjects met the study criteria for dysphagia

2018 PLoS ONE

94. Psychometric properties of the German version of the Leicester Cough Questionnaire in sarcoidosis. Full Text available with Trip Pro

Psychometric properties of the German version of the Leicester Cough Questionnaire in sarcoidosis. Cough is one of the most common symptoms in general and pulmonary medicine with profound negative impact on health-related quality of life (HRQL). The Leicester Cough Questionnaire (LCQ) is a validated HRQL questionnaire, yet a validated German version of the LCQ is not available and it has never been tested in a cohort with sarcoidosis.To translate the LCQ into German and determine its

2018 PLoS ONE

95. Is honey an effective treatment for acute cough in children? Full Text available with Trip Pro

Is honey an effective treatment for acute cough in children? Cough represents one of the most common reasons for pediatrician consultations. There are many available treatments for symptomatic relief, including honey. Despite its wide availability, there is little knowledge about its benefits. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified three systematic reviews including three randomized trials. We combined the evidence using meta-analysis (...) and generated a summary of findings table following the GRADE approach. We concluded the use of honey probably decreases the severity and frequency of cough, improves the quality of parent's and patient's sleep, and does not have side effects.

2017 Medwave

96. Computational Modelling of Cough Function and Airway Penetrant Behavior in Patients with Disorders of Laryngeal Function Full Text available with Trip Pro

Computational Modelling of Cough Function and Airway Penetrant Behavior in Patients with Disorders of Laryngeal Function Patients with laryngeal disorders often exhibit changes to cough function contributing to aspiration episodes. Two primary cough variables (peak cough flow: PCF and compression phase duration: CPD) were examined within a biomechanical model to determine their impact on characteristics that impact airway compromise.Computational study.A Computational Fluid Dynamics (CFD (...) ) technique was used to simulate fluid flow within an upper airway model reconstructed from patient CT images. The model utilized a finite-volume numerical scheme to simulate cough-induced airflow, allowing for turbulent particle interaction, collision, and break-up. Liquid penetrants at 8 anatomical release locations were tracked during the simulated cough. Cough flow velocity was computed for a base case and four simulated cases. Airway clearance was evaluated through assessment of the fate of particles

2017 Laryngoscope investigative otolaryngology

97. Psychological profile of individuals presenting with chronic cough Full Text available with Trip Pro

Psychological profile of individuals presenting with chronic cough Chronic refractory cough (CRC) is a common problem in respiratory clinics. Adverse effects on quality of life are documented in the literature, but relatively little is known about the underlying psychological factors in this patient population. We aimed to investigate the association of psychological factors with chronic cough, comparing CRC to explained cough and non-cough groups. 67 patients attending a specialist cough (...) clinic (CRC, n=25; explained cough, n=42) and 22 non-cough individuals participated. All participants completed the Hospital Anxiety & Depression Scale, Big Five Inventory (Personality), Chalder Fatigue Scale and Patient Health Questionnaire-15. Cough patients also completed the Illness Perception Questionnaire-Revised. Appropriate statistical analyses were used to compare participant groups. Chronic refractory coughers displayed significantly higher levels of anxiety, depression, fatigue and somatic

2017 ERJ open research

98. Treatment of Unexplained Chronic Cough

Treatment of Unexplained Chronic Cough Treatment of Unexplained Chronic Cough CHEST Guideline and Expert Panel Report Peter Gibson, MBBS; Gang Wang, MD, PhD; Lorcan McGarvey, MD; Anne E. Vertigan, PhD, MBA, BAppSc (SpPath); Kenneth W. Altman, MD, PhD; and Surinder S. Birring, MB ChB, MD; on behalf of the CHEST Expert Cough Panel BACKGROUND: Unexplained chronic cough (UCC) causes signi?cant impairments in quality of life. Effective assessment and treatment approaches are needed for UCC. METHODS (...) : This systematic review of randomized controlled trials (RCTs) asked: What is the ef?cacy of treatment compared with usual care for cough severity, cough frequency, and cough-related quality of life in patients with UCC? Studies of adults and adolescents aged> 12 years with a chronic cough of> 8 weeks’ duration that was unexplained after systematic investigation and treatment were included and assessed for relevance and quality. Based on the systematic review, guideline suggestions were developed and voted

2016 American College of Chest Physicians

99. Occupational and Environmental Contributions to Chronic Cough in Adults

Occupational and Environmental Contributions to Chronic Cough in Adults Occupational and Environmental Contributions to Chronic Cough in Adults Chest Expert Panel Report Susan M. Tarlo, MBBS, FCCP; Kenneth W. Altman, MD, PhD; John Oppenheimer, MD; Kaiser Lim, MD; Anne Vertigan, PhD; David Prezant, MD; and Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel BACKGROUND: In response to occupational and environmental exposures, cough can be an isolatedsymptomre?ecting (...) exposuretoanirritantwithlittlephysiologicalconsequence,orit can be a manifestation of more signi?cant disease. This document reviews occupational and environmental contributions to chronic cough in adults, focusing on aspects not previously covered in the 2006 ACCP Cough Guideline or our more recent systematic review, and suggests an approach to investigation of these factors when suspected. METHODS: MEDLINE and TOXLINE literature searches were supplemented by articles identi?edbythecoughpaneloccupationalandenvironmentalsubgroupmembers,toidentify

2016 American College of Chest Physicians

100. Chronic Cough Due to Gastroesophageal Reflux in Adults

Chronic Cough Due to Gastroesophageal Reflux in Adults Chronic Cough Due to Gastroesophageal Re?ux in Adults CHEST Guideline and Expert Panel Report Peter J. Kahrilas, MD; Kenneth W. Altman, MD, PhD; Anne B. Chang, PhD; Stephen K. Field, MD, FCCP; Susan M. Harding, MD, FCCP; Andrew P. Lane, MD; Kaiser Lim, MD, FCCP; Lorcan McGarvey, MD; Jaclyn Smith, PhD; and Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel BACKGROUND: We updated the 2006 ACCP clinical practice (...) guidelines for management of re?ux-cough syndrome. METHODS: Two population, intervention, comparison, outcome (PICO) questions were addressed by systematic review: (1) Can therapy for gastroesophageal re?ux improve or eliminatecoughinadultswithchronicandpersistentlytroublesomecough?and(2)Arethere minimal clinical criteria to guide practice in determining that chronic cough is likely to respond to therapy for gastroesophageal re?ux? RESULTS: We found no high-quality studies pertinent to either question

2016 American College of Chest Physicians

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