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61. Use of honey associated with Ananas comosus (Bromelin) in the treatment of acute irritative cough. (PubMed)

Use of honey associated with Ananas comosus (Bromelin) in the treatment of acute irritative cough. To evaluate the immediate improvement rate of irritative cough in patients treated with the combination of Ananas comosus extract and honey (Bromelin®) compared with the use of honey alone (placebo group).Pragmatic, double-blind, randomized, parallel-group study with children aged between 2 and 15 years, with irritative cough for at least 24hours. The double-blind assessment of cough was through (...) the number of observed coughing episodes and intensity score for a period of 10minutes of observation. The decrease of one point in the mean total score was considered as a therapeutic effect.There was a reduction in coughing episodes in both groups, as well as in the cough score after 30minutes of drug or honey administration. The change in clinical score above two points, which could indicate marked improvement, occurred in five patients in the bromelin group and only in one in the placebo group

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2018 Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo

62. Comparison of the effects of pretreatment intravenous fentanyl or intravenous lidocaine on suppression of fentanyl-induced cough in children: a randomized, double-blind, controlled clinical trial (PubMed)

Comparison of the effects of pretreatment intravenous fentanyl or intravenous lidocaine on suppression of fentanyl-induced cough in children: a randomized, double-blind, controlled clinical trial The injection of fentanyl usually causes coughing during induction of anesthesia. Based on a few studies about effects of lidocaine and the fact there is no study concerning the effect of fentanyl on fentanyl-induced cough in pediatric patients, the aim of this study was to compare the effectiveness (...) of low dose of fentanyl with lidocaine in prevention of fentanyl-induced cough in children.This randomized double-blind controlled clinical trial study was conducted at Motahari Hospital between February and August 2017 in Urmia (Iran). One hundred patients, aged 2-10 years, of class I or II ASA status who were candidates for elective herniorrhaphy under general anesthesia were enrolled in this study. They were randomly divided into three groups. One minute before the administration of 2 μg/kg

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2018 Electronic physician

63. The impacts of cough: a cross-sectional study in a Finnish adult employee population (PubMed)

The impacts of cough: a cross-sectional study in a Finnish adult employee population Given the very high prevalence of cough, little is known about its impacts. A questionnaire was sent via e-mail to all public service employees in two towns in Finland. There were 373 subjects with acute cough, 174 with subacute cough and 421 with chronic cough. Cough-related quality of life was assessed with the Leicester Cough Questionnaire (LCQ) and depressive symptoms with Patient Health Questionnaire-2 (...) . In addition, data on doctor's visits and sick leave days were collected. Mean LCQ (95% CI) total scores were 16.2 (15.9-16.5), 14.5 (14.1-15.0) and 14.6 (14.3-14.9) among subjects with acute, subacute and chronic cough, respectively (p<0.001). The prevalence of depressive symptoms was 5.4%, 7.5% and 4.8%, respectively, and 5.0% among subjects without current cough (p=0.50). The respective proportions of subjects with at least one doctor's visit due to cough during the previous year were 27.6%, 44.8%, 49.6

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2018 ERJ open research

64. Vertical diplopia and oscillopsia due to midbrain keyhole aqueduct syndrome associated with severe cough (PubMed)

Vertical diplopia and oscillopsia due to midbrain keyhole aqueduct syndrome associated with severe cough Midline structural defects in the neural axis can give rise to neuro-ophthalmic symptoms. We report a rare case of keyhole aqueduct syndrome presenting after two years of severe cough due to gastroesophageal reflux disease.A 58-year-old woman with a 2-year history of daily, severe cough presented to the neuro-ophthalmology clinic with progressive diplopia and oscillopsia. Examination (...) in the ventral midbrain communicating with the cerebral aqueduct, consistent with keyhole aqueduct syndrome. Her nystagmus and diplopia improved with oral acetazolamide treatment, at high doses of 2500-3000 mg per day.We report the first case of midbrain keyhole aqueduct syndrome with ocular motor and other neuro-ophthalmic manifestations associated with severe cough. Although her cough was effectively treated and intracranial pressure measurement was normal, her ophthalmic symptoms continued to progress

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2018 American journal of ophthalmology case reports

65. Validation of the Mandarin Chinese version of the Leicester Cough Questionnaire in non‐small cell lung cancer patients after surgery (PubMed)

Validation of the Mandarin Chinese version of the Leicester Cough Questionnaire in non‐small cell lung cancer patients after surgery There are no validated and reliable cough-specific instruments to assess health-related quality of life with respect to postoperative cough in non-small cell lung cancer (NSCLC) patients. We used the Leicester Cough Questionnaire in Mandarin-Chinese (LCQ-MC) and investigated the validity, reliability, and repeatability of this instrument.A total of 130 NSCLC (...) patients (average age 58.75 ± 9.43 years, 65 men, 65 women) completed the LCQ-MC, cough Visual Analogue Scale (VAS), Cough Symptom Score (CSS), Hospital Anxiety and Depression Scale (HADS), and Medical Outcomes Study 36-item Short-Form Health Survey (SF-36). Forty patients completed the LCQ-MC again one week later. Concurrent validity, internal consistency, and repeatability were assessed.Analyses of concurrent validity showed significant correlations between the LCQ-MC and the cough VAS (r = -0.488

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2018 Thoracic cancer

66. An advanced recording and analysis system for the differentiation of guinea pig cough responses to citric acid and prostaglandin E2 in real time. (PubMed)

An advanced recording and analysis system for the differentiation of guinea pig cough responses to citric acid and prostaglandin E2 in real time. Cough number and/or sound have been used to assess cough sensitivity/intensity and to discriminate cough patterns in clinical settings. However, to date, only manual counting of cough number in an offline manner is applied in animal cough studies, which diminishes the efficiency of cough identification and hinders the diagnostic discrimination (...) of cough patterns, especially in animals with pulmonary diseases. This study aims to validate a novel recording/analysis system by which cough numbers are automatically counted and cough patterns are comprehensively differentiated in real time. The experiment was carried out in conscious guinea pigs exposed to aerosolized citric acid (CA, 150 mM) and prostaglandin E2 (PGE2, 0.43 mM). Animal body posture (video), respiratory flow, and cough acoustics (audio) were simultaneously monitored and recorded

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2019 PLoS ONE

67. Health seeking behavior among individuals presenting with chronic cough at referral hospitals in Uganda; Missed opportunity for early tuberculosis diagnosis. (PubMed)

Health seeking behavior among individuals presenting with chronic cough at referral hospitals in Uganda; Missed opportunity for early tuberculosis diagnosis. Tuberculosis (TB) is the 9th leading cause of death from a single infectious agent. Patients live in a complex health care system with both formal and informal providers, and it is important that a TB diagnosis is not missed at the first interaction with the health care system. In this study, we highlight the health seeking behavior (...) of patients and missed opportunities for early TB diagnosis for which interventions could be instituted to ensure early TB diagnosis and prompt TB treatment initiation.This study was nested in a cross-sectional study that assessed the accuracy of different Xpert MTB/Rif implementation strategies in programmatic settings at the referral hospitals in Uganda. We documented the symptom profile of presumptive TB patients and assessed the health seeking behavior of those with chronic cough by calculating

2019 PLoS ONE

68. Beta2-agonists for acute cough or a clinical diagnosis of acute bronchitis. (PubMed)

Beta2-agonists for acute cough or a clinical diagnosis of acute bronchitis. The diagnosis of acute bronchitis is made on clinical grounds and a variety of clinical definitions have been used. There are no clearly effective treatments for the cough of acute bronchitis. Beta2-agonists are often prescribed, perhaps because clinicians suspect many patients also have reversible airflow restriction (as seen in asthma or chronic obstructive pulmonary disease (COPD)) contributing to the symptoms.To (...) cough and without known pulmonary disease to beta2-agonist versus placebo, no treatment or alternative treatment.Three review authors independently selected outcomes and extracted data while blinded to study results. Two review authors independently assessed each trial for risk of bias. We analysed trials in children and adults separately.Two trials of moderate quality in children (n = 134) with no evidence of airflow restriction did not find any benefits from oral beta2-agonists. Five trials

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2015 Cochrane

69. Interventions for cough in cancer. (PubMed)

Interventions for cough in cancer. This is an updated version of the original Cochrane review first published in Issue 9, 2010 on "Interventions for cough in cancer". Cough is a common symptom in patients with malignancies, especially in patients with lung cancer. Cough is not well controlled in clinical practice and clinicians have few management options to treat it.The primary objective was to determine the effectiveness of interventions, both pharmacological and non-pharmacological, (other (...) than chemotherapy and external beam radiotherapy) in the management of cough in malignant disease (especially in lung cancer).For this update, we searched for relevant studies in CENTRAL and DARE (The Cochrane Library); MEDLINE; EMBASE; PsycINFO; AMED and CINAHL to 9 June 2014. In addition, we searched for ongoing trials via the metaRegister of controlled trials (mRCT), ClinicalTrials.gov, the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) and the UK

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2015 Cochrane

70. Honey for coughs in children with URTI

Honey for coughs in children with URTI RACGP - Honey and cough in children with URTI Search Become a student member today for free and be part of the RACGP community A career in general practice Starting the GP journey Enrolments for the 2019.1 OSCE FRACGP exams closing 29 March 2019 Fellowship FRACGP exams Research Practice Experience Program is a self-directed education program designed to support non vocationally registered doctors on their pathway to RACGP Fellowship Fellowship (...) Media Releases 2013 Media Releases 2012 Media Releases Search Honey and cough in children with URTI Honey and cough in children with URTI Introduction Cough associated with an URTI in children does not require treatment but treatment may be necessary when the cough interferes with sleep. Indication Honey may be used if a cough suppressant is sought for the short-term symptomatic relief of nocturnal cough in children (12 months to 18 years of age) with an URTI after other causes of the cough have

2014 Handbook of Non-Drug interventions (HANDI)

71. Cough Due to TB and Other Chronic Infections: CHEST Guideline and Expert Panel Report

Cough Due to TB and Other Chronic Infections: CHEST Guideline and Expert Panel Report Cough is common in pulmonary TB and other chronic respiratory infections. Identifying features that predict whether pulmonary TB is the cause would help target appropriate individuals for rapid and cost-effective screening, potentially limiting disease progression and preventing transmission to others.A systematic literature search for individual studies to answer eight key questions (KQs) was conducted (...) according to established Chest Organization methods by using the following databases: MEDLINE via PubMed, Embase, Scopus, and the Cochrane Database of Systematic Reviews from January 1, 1984, to April 2014. Searches for KQ 1 and KQ 3 were updated in February 2016. An updated KQ 2 search was undertaken in March 2017.Even where TB prevalence is greatest, most individuals with cough do not have pulmonary TB. There was no evidence that 1, 3, or 4 weeks' duration were better predictors than cough lasting ≥ 2

2018 EvidenceUpdates

72. Treatments for subacute cough in primary care: systematic review and meta-analyses of randomised clinical trials

Treatments for subacute cough in primary care: systematic review and meta-analyses of randomised clinical trials Subacute cough following a non-specific viral infection lasting 3-8 weeks is common. However, despite many treatment options there are no systematic reviews evaluating these.To provide a systematic overview of treatment options and outcomes evaluated in randomised clinical trials (RCTs).Systematic review and meta-analyses assessing the overall effects of any treatment for subacute (...) cough.The authors systematically searched PubMed/MEDLINE and the Cochrane Central Register of Controlled Trials (last search March 2017) for RCTs in adult patients with subacute cough. The authors considered trials evaluating any outcome of any drug or non-drug treatments, apart from traditional Chinese and Asian medicines. They combined treatment effects on cough-related outcomes in random effects meta-analyses.Six eligible RCTs including 724 patients were identified. These assessed montelukast

2018 EvidenceUpdates

73. Acellular vaccines for preventing whooping cough in children. (PubMed)

Acellular vaccines for preventing whooping cough in children. Routine use of whole-cell pertussis (wP) vaccines was suspended in some countries in the 1970s and 1980s because of concerns about adverse effects. Following this action, there was a resurgence of whooping cough. Acellular pertussis (aP) vaccines, containing purified or recombinant Bordetella pertussis (B. pertussis) antigens, were developed in the hope that they would be as effective, but less reactogenic than the whole-cell (...) with a total of 136,541 participants. Most of the safety trials did not report the methods for random sequence generation, allocation concealment and blinding, which made it difficult to assess the risk of bias in the studies. The efficacy of multi-component (≥ three) vaccines varied from 84% to 85% in preventing typical whooping cough (characterised by 21 or more consecutive days of paroxysmal cough with confirmation of B. pertussis infection by culture, appropriate serology or contact with a household

2014 Cochrane

74. Clinical pathways for chronic cough in children. (PubMed)

Clinical pathways for chronic cough in children. Chronic cough (a cough lasting longer than four weeks) is a common problem internationally. Chronic cough has associated economic costs and is distressing to the child and to parents; ignoring cough may lead to delayed diagnosis and progression of serious underlying respiratory disease. Clinical guidelines have been shown to lead to efficient and effective patient care and can facilitate clinical decision making. Cough guidelines have been (...) designed to facilitate the management of chronic cough. However, treatment recommendations vary, and specific clinical pathways for the treatment of chronic cough in children are important, as causes of and treatments for cough vary significantly from those in adults. Therefore, systematic evaluation of the use of evidence-based clinical pathways for the management of chronic cough in children would be beneficial for clinical practice and for patient care. Use of a management algorithm can improve

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2014 Cochrane

75. Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults. (PubMed)

Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults. Cough is often distressing for patients with pneumonia. Accordingly they often use over-the-counter (OTC) cough medications (mucolytics or cough suppressants). These might provide relief in reducing cough severity, but suppression of the cough mechanism might impede airway clearance and cause harm.To evaluate the efficacy of OTC cough medications as an adjunct (...) to antibiotics in children and adults with pneumonia.We searched CENTRAL 2013, Issue 12, MEDLINE (January 1966 to January week 2, 2014), OLDMEDLINE (1950 to 1965), EMBASE (1980 to January 2014), CINAHL (2009 to January 2014), LILACS (2009 to January 2014) and Web of Science (2009 to January 2014).Randomised controlled trials (RCTs) in children and adults comparing any type of OTC cough medication with placebo, or control medication, with cough as an outcome and where the cough is secondary to acute

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2014 Cochrane

76. Honey for acute cough in children. (PubMed)

Honey for acute cough in children. Cough causes concern for parents and is a major cause of outpatient visits. It can impact on quality of life, cause anxiety and affect sleep in parents and children. Several remedies, including honey, have been used to alleviate cough symptoms.To evaluate the effectiveness of honey for acute cough in children in ambulatory settings.We searched CENTRAL (2014, Issue 10), MEDLINE (1950 to October week 4, 2014), EMBASE (1990 to November 2014), CINAHL (1981 (...) to November 2014), Web of Science (2000 to November 2014), AMED (1985 to November 2014), LILACS (1982 to November 2014) and CAB abstracts (2009 to January 2014).Randomised controlled trials (RCTs) comparing honey given alone, or in combination with antibiotics, versus nothing, placebo or other over-the-counter (OTC) cough medications to participants aged from one to 18 years for acute cough in ambulatory settings.Two review authors independently screened search results for eligible studies and extracted

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2014 Cochrane

77. Over-the-counter (OTC) medications for acute cough in children and adults in community settings. (PubMed)

Over-the-counter (OTC) medications for acute cough in children and adults in community settings. Acute cough due to upper respiratory tract infection (URTI) is a common symptom. Non-prescription, over-the-counter (OTC) medicines are frequently recommended as a first-line treatment, but there is little evidence as to whether these drugs are effective.To assess the effects of oral OTC cough preparations for acute cough in children and adults in community settings.We searched CENTRAL (2014, Issue (...) 1), MEDLINE (January 1966 to March week 3 2014), EMBASE (January 1974 to March 2014), CINAHL (January 2010 to March 2014), LILACS (January 2010 to March 2014), Web of Science (January 2010 to March 2014) and the UK Department of Health National Research Register (March 2010).Randomised controlled trials (RCTs) comparing oral OTC cough preparations with placebo in children and adults suffering from acute cough in community settings. We considered all cough outcomes; secondary outcomes of interest

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2014 Cochrane

78. Treatment of Interstitial Lung Disease Associated Cough: CHEST Guideline and Expert Panel Report

Treatment of Interstitial Lung Disease Associated Cough: CHEST Guideline and Expert Panel Report Chronic cough in interstitial lung disease (ILD) causes significant impairment in quality of life. Effective treatment approaches are needed for cough associated with ILD.This systematic review asked: Is there evidence of clinically relevant treatment effects for therapies for cough in ILD? Studies of adults aged > 18 years with a chronic cough ≥ 8 weeks' duration were included and assessed (...) for relevance and quality. Based on the systematic review, guideline suggestions were developed and voted on by using CHEST guideline methodology.Eight randomized controlled trials and two case series (≥ 10 patients) were included that reported data on patients with idiopathic pulmonary fibrosis, sarcoidosis, and scleroderma-related ILD who received a variety of interventions. Study quality was high in all eight randomized controlled trials. Inhaled corticosteroids were not supported for cough associated

2018 EvidenceUpdates

79. Cough

Cough Scottish Palliative Care Guidelines - Cough Scottish Palliative Care Guidelines search / / / Cough Cough Introduction Cough is a forced expulsive manoeuvre usually against a closed glottis, which is associated with a characteristic sound. It usually has a protective function in maintaining patency and cleanliness of the airways. The impact of cough on patients and relatives is often underestimated. Patients may need symptomatic treatment when cough is persistent, distressing or affecting (...) sleep and/or quality of life. An assessment of the pattern and character of the patient's cough is essential to optimise treatment. Acute cough is defined as duration of <3 weeks, subacute as 3 to 8 weeks, chronic as >8 weeks. For information on the nature of cough, see the Management section. Assessment Ask the patient to rate cough frequency, severity and level of associated distress or anxiety. Explore: understanding of the reasons for cough fears (including fear of choking) impact on: functional

2015 Scottish Palliative Care Guidelines

80. Is honey an effective treatment for acute cough in children?

Is honey an effective treatment for acute cough in children? Cough represents one of the most common reasons for pediatrician consultations. There are many available treatments for symptomatic relief, including honey. Despite its wide availability, there is little knowledge about its benefits. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified three systematic reviews including three randomized trials. We combined the evidence using meta-analysis (...) and generated a summary of findings table following the GRADE approach. We concluded the use of honey probably decreases the severity and frequency of cough, improves the quality of parent's and patient's sleep, and does not have side effects.

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2017 Medwave

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