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21. Subfreezing air as a cough trigger and multiple triggers are strongly associated with the presence of asthma in chronic cough. (PubMed)

Subfreezing air as a cough trigger and multiple triggers are strongly associated with the presence of asthma in chronic cough. Management of chronic cough relies on the recognition of cough background disorders. It is not known whether certain cough triggers are associated with specific background disorders.This was an e-mail study to public service employees of two towns in Finland. The questionnaire included twelve triggers. Current asthma was defined as doctor's diagnosis of asthma (...) and current wheezing. Chronic rhinosinusitis was defined as either nasal blockage or nasal discharge and either facial pain/pressure or reduction/loss of smell for more than three months. Gastroesophageal reflux disease was defined as heartburn and/or regurgitation on at least one day a week during the last three months. Idiopathic cough was defined as absence of any of them.There were 421 subjects with current cough that had lasted at least eight weeks. Subfreezing air as a cough trigger was associated

2019 Respiratory medicine

22. Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough. (PubMed)

Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough. The differential sensitivity of cough to antitussive therapies implies the existence of heterogeneity in cough hypersensitivity, but how such heterogeneity is expressed across individual patients is poorly understood. We investigated the phenotypes of cough hypersensitivity by examining transient receptor potential ankyrin 1 (TRPA1)- and transient receptor potential vanilloid 1 (TRPV1 (...) )-mediated cough sensitivity in patients with chronic refractory cough.Using a selective TRPA1 agonist, allyl isothiocyanate (AITC), we established an AITC cough challenge as a measure of TRPA1-mediated cough sensitivity. The AITC cough challenge and the widely used capsaicin (a selective TRPV1 agonist) cough challenge were performed with 250 patients with chronic refractory cough and 56 healthy subjects. The concentration of AITC or capsaicin solution causing at least two (C2) and five coughs (C5

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2019 Respiratory research

23. Typical symptoms and not positive reflux-cough correlation predict cure of gastroesophageal reflux disease related chronic cough after laparoscopic fundoplication: a retrospective study. (PubMed)

Typical symptoms and not positive reflux-cough correlation predict cure of gastroesophageal reflux disease related chronic cough after laparoscopic fundoplication: a retrospective study. The effect of laparoscopic fundoplication on reflux-related chronic cough is unpredictable, the aim of the study is to investigate the predictive effect of positive reflux-cough correlation on the resolution of reflux-related chronic cough after anti-reflux surgery.A 5 years retrospective review was performed (...) . Logistic regression analysis was used to determine the independent predictors on the cure of chronic cough.Seventy-nine patients were included in this study, among which chronic cough was cured in 47 (59.5%) and significantly improved in 10 (12.7%) patients. Present of typical symptoms (odds ratio = 6.435,95% confidence interval [CI] = 1.427-29.032, p = 0.015) and number of Reflux episodes (impedance) ≥73 (odds ratio = 0.306, 95% confidence interval [CI] = 0.107-0.874, p = 0.027) were significantly

2019 BMC Gastroenterology

24. Cough presentation in primary care and the identification of chronic cough: a need for diagnostic clarity? (PubMed)

Cough presentation in primary care and the identification of chronic cough: a need for diagnostic clarity? Objective: To investigate patterns of presentation of cough in primary care and develop an algorithm to identify probable and possible chronic cough (CC). Methods: This retrospective observational study used routine English primary care data and linked hospital data. Patients with ≥1 cough event in the study period (March 2014-February 2015) were selected. Index date (...) was that of the earliest cough event in this period. Adults (aged ≥18 years) were classified as having probable CC if they had an explicit CC diagnosis; as having possible CC if they had ≥3 cough events recorded over 8-26 weeks; or, otherwise, as having acute cough. Underlying conditions associated with CC were identified. Results: 198,151 people were identified. 56.5% were female; median age was 47.0 years. The prevalence of cough in the study year was 17.6%. Of the 150,213 identified adults, 1600 (1.1%), 10,913 (7.3

2019 Current medical research and opinion

25. Quantifying test-retest variability of natural and suppressed citric acid cough thresholds and urge to cough ratings. (PubMed)

Quantifying test-retest variability of natural and suppressed citric acid cough thresholds and urge to cough ratings. The citric acid cough reflex test (CRT) is used to quantify cough sensitivity and evaluate the effects of cough therapies and antitussive medications. This study quantifies the test-retest variability of natural and suppressed citric acid cough thresholds and urge to cough ratings in healthy individuals.Healthy adults (n = 16) inhaled increasing concentrations of citric acid (...) (0.01-3.2 mol/L) on three alternate days (1, 3, 5) until C2 cough thresholds (i.e. two consecutive coughs within 3 s) or the highest concentrations of citric acid was reached. Participants were instructed to "cough if you need to" in the natural cough condition, and "try not to cough" in the suppressed cough condition. Following each inhalation, participants were asked to rate their urge to cough (UTC) using a modified Borg Scale.Natural cough thresholds (NCTs) increased across days 1-3 (0.87

2019 Pulmonary Pharmacology & Therapeutics

26. Cough Due to Tuberculous and Other Chronic Infections

Cough Due to Tuberculous and Other Chronic Infections Cough Due to TB and Other Chronic Infections CHEST Guideline and Expert Panel Report Stephen K. Field, MD,CM, FCCP; Patricio Escalante, MD, FCCP; Dina A. Fisher, MD, FCCP; Belinda Ireland, MD; Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel BACKGROUND: Cough is common in pulmonary TB and other chronic respiratory infections. Identifying features that predict whether pulmonary TB is the cause would help target (...) in February 2016. An updated KQ 2 search was undertaken in March 2017. RESULTS: Even where TB prevalence is greatest, most individuals with cough do not have pulmonary TB. There was no evidence that 1, 3, or 4 weeks’ duration were better predictors than cough lasting $ 2 weeks to screen for pulmonary TB. In people living with HIV (PLWHIV), screening for fever, night sweats, hemoptysis, and/or weight loss in addition to cough(any WorldHealthOrganization[WHO]-endorsed symptom)increasesthediagnostic

2018 American College of Chest Physicians

27. Chronic Cough Related to Acute Viral Bronchiolitis in Children

Chronic Cough Related to Acute Viral Bronchiolitis in Children Chronic Cough Related to Acute Viral Bronchiolitis in Children CHEST Expert Panel Report Anne B. Chang, MBBS, PhD, MPH; John J. Oppenheimer, MD; Bruce K. Rubin, MD; Miles Weinberger, MD, FCCP; and Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel BACKGROUND: Acute bronchiolitis is common in young children, and some children develop chronic cough after their bronchiolitis. We thus undertook systematic (...) reviews based on key questions (KQs) using the PICO (Population, Intervention, Comparison, Outcome) format. The KQs were: Among children with chronic cough (> 4 weeks) after acute viral bron- chiolitis, how effective are the following interventions in improving the resolution of cough?: (1) Antibiotics. If so what type and for how long? (2) Asthma medications (inhaled steroids, beta 2 agonist, montelukast); and (3) Inhaled osmotic agents like hypertonic saline? METHODS: We used the CHEST expert cough

2018 American College of Chest Physicians

28. Classification of cough as a symptom in adults and management algorithms: CHEST guideline and Expert Panel report.

Classification of cough as a symptom in adults and management algorithms: CHEST guideline and Expert Panel report. Classification of cough as a symptom in adults and management algorithms: CHEST guideline and Expert Panel report. | National Guideline Clearinghouse success fail May JUN 09 2017 2018 2019 19 May 2018 - 12 Jul 2018 COLLECTED BY Organization: Formed in 2009, the Archive Team (not to be confused with the archive.org Archive-It Team) is a rogue archivist collective dedicated to saving (...) of cough as a symptom in adults and management algorithms: CHEST guideline and Expert Panel report. Irwin RS, French CL, Chang AB, Altman KW, CHEST Expert Cough Panel. Classification of cough as a symptom in adults and management algorithms: CHEST guideline and Expert Panel Report. Chest. 2018 Jan;153(1):196-209. [35 references] This is the current release of the guideline. This guideline meets NGC's 2013 (revised) inclusion criteria. Age Group UMLS Concepts ICD9CM (786.2) MSH , , , , , , , MTH

2018 National Guideline Clearinghouse (partial archive)

29. Comparison of a Protective Cough Syrup Against Placebo on Night Cough in Children 1-5 Years Coughing Since 1- 2 Days Due to Common Cold

Comparison of a Protective Cough Syrup Against Placebo on Night Cough in Children 1-5 Years Coughing Since 1- 2 Days Due to Common Cold Comparison of a Protective Cough Syrup Against Placebo on Night Cough in Children 1-5 Years Coughing Since 1- 2 Days Due to Common Cold - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning (...) You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Comparison of a Protective Cough Syrup Against Placebo on Night Cough in Children 1-5 Years Coughing Since 1- 2 Days Due to Common Cold The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider

2017 Clinical Trials

30. [Fractional exhaled nitric oxide measurement in patients with asthma and chronic cough]

[Fractional exhaled nitric oxide measurement in patients with asthma and chronic cough] [Fractional exhaled nitric oxide measurement in patients with asthma and chronic cough] [Fractional exhaled nitric oxide measurement in patients with asthma and chronic cough] Virgilio S, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation Virgilio S, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A. [Fractional exhaled nitric oxide measurement in patients with asthma and chronic cough] Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Documentos de Evaluación de Tecnologías Sanitarias, Informe de Respuesta Rapida No 536. 2017 Authors' conclusions Moderate quality evidence suggests that fractional exhaled

2017 Health Technology Assessment (HTA) Database.

31. Codeine versus placebo for chronic cough in children. (PubMed)

Codeine versus placebo for chronic cough in children. Cough in children is a commonly experienced symptom that is associated with increased health service utilisation and burden to parents. The presence of chronic (equal to or more than four weeks) cough in children may indicate a serious underlying condition such as inhaled foreign body or bronchiectasis. Codeine (and derivative)-based medications are sometimes used to treat cough due to their antitussive properties. However (...) , there are inherent risks associated with the use of these medications such as respiratory drive suppression, anaesthetic-induced anaphylaxis, and addiction. Metabolic response and dosage variability place children at increased risk of experiencing such side effects. A systematic review evaluating the quality of the available literature would be useful to inform management practices.To evaluate the safety and efficacy of codeine (and derivatives) in the treatment of chronic cough in children.We searched

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2016 Cochrane

32. Combination Inhaled Corticosteroids and Long-Acting Beta2-Agonists for Acute Respiratory Tract Infections and Cough: Clinical Effectiveness

Combination Inhaled Corticosteroids and Long-Acting Beta2-Agonists for Acute Respiratory Tract Infections and Cough: Clinical Effectiveness Combination Inhaled Corticosteroids and Long-Acting Beta2-Agonists for Acute Respiratory Tract Infections and Cough: Clinical Effectiveness | CADTH.ca Find the information you need Combination Inhaled Corticosteroids and Long-Acting Beta2-Agonists for Acute Respiratory Tract Infections and Cough: Clinical Effectiveness Combination Inhaled Corticosteroids (...) and Long-Acting Beta2-Agonists for Acute Respiratory Tract Infections and Cough: Clinical Effectiveness Published on: June 15, 2016 Project Number: RB0996-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of combination inhaled corticosteroids and long-acting beta2-agonists for patients with acute bacterial upper respiratory tract infections? What is the clinical effectiveness of combination inhaled corticosteroids

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

33. Use of management pathways or algorithms in children with chronic cough: CHEST guideline and Expert Panel report.

Use of management pathways or algorithms in children with chronic cough: CHEST guideline and Expert Panel report. Use of management pathways or algorithms in children with chronic cough: CHEST guideline and Expert Panel report. | National Guideline Clearinghouse success fail JUN 09 2017 2018 2019 14 Apr 2018 - 12 Jul 2018 COLLECTED BY Organization: Formed in 2009, the Archive Team (not to be confused with the archive.org Archive-It Team) is a rogue archivist collective dedicated to saving (...) of management pathways or algorithms in children with chronic cough: CHEST guideline and Expert Panel report. Chang AB, Oppenheimer JJ, Weinberger MM, Rubin BK, Weir K, Grant CC, Irwin RS, CHEST Expert Cough Panel. Use of management pathways or algorithms in children with chronic cough: CHEST guideline and Expert Panel report. Chest. 2017 Apr;151(4):875-83. [48 references] This is the current release of the guideline. This guideline meets NGC's 2013 (revised) inclusion criteria. Age Group UMLS Concepts

2017 National Guideline Clearinghouse (partial archive)

34. Management of children with chronic wet cough and protracted bacterial bronchitis: CHEST guideline and Expert Panel report.

Management of children with chronic wet cough and protracted bacterial bronchitis: CHEST guideline and Expert Panel report. Management of children with chronic wet cough and protracted bacterial bronchitis: CHEST guideline and Expert Panel report. | National Guideline Clearinghouse success fail JUN 10 2017 2018 2019 14 Apr 2018 - 13 Jul 2018 COLLECTED BY Organization: Formed in 2009, the Archive Team (not to be confused with the archive.org Archive-It Team) is a rogue archivist collective (...) of children with chronic wet cough and protracted bacterial bronchitis: CHEST guideline and Expert Panel report. Chang AB, Oppenheimer JJ, Weinberger MM, Rubin BK, Grant CC, Weir K, Irwin RS, CHEST Expert Cough Panel. Management of children with chronic wet cough and protracted bacterial bronchitis: CHEST guideline and Expert Panel report. Chest. 2017 Apr;151(4):884-90. [33 references] This is the current release of the guideline. This guideline updates a previous version: Chang AB, Glomb WB. Guidelines

2017 National Guideline Clearinghouse (partial archive)

35. Combination Inhaled Corticosteroids and Long-Acting Beta2-Agonists for Acute Respiratory Tract Infections and Cough: A Review of the Clinical Effectiveness

Combination Inhaled Corticosteroids and Long-Acting Beta2-Agonists for Acute Respiratory Tract Infections and Cough: A Review of the Clinical Effectiveness Combination Inhaled Corticosteroids and Long-Acting Beta2-Agonists for Acute Respiratory Tract Infections and Cough: A Review of the Clinical Effectiveness | CADTH.ca Find the information you need Combination Inhaled Corticosteroids and Long-Acting Beta2-Agonists for Acute Respiratory Tract Infections and Cough: A Review of the Clinical (...) Effectiveness Combination Inhaled Corticosteroids and Long-Acting Beta2-Agonists for Acute Respiratory Tract Infections and Cough: A Review of the Clinical Effectiveness Published on: July 6, 2016 Project Number: RC0790-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of combination inhaled corticosteroids (ICSs) and long-acting beta2-agonists (LABAs) for patients with acute bacterial upper respiratory tract

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

36. Cough in Ambulatory Immunocompromised Adults

Cough in Ambulatory Immunocompromised Adults CoughinAmbulatoryImmunocompromised Adults CHEST Expert Panel Report Mark J. Rosen, MD, Master FCCP; Belinda Ireland, MD; Mangala Narasimhan, DO, FCCP; Cynthia French, PhD, FCCP; Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel BACKGROUND: Cough is a common symptom prompting patients to seek medical care. Like patients in the general population, patients with compromised immune systems also seek care for cough. However (...) , it is unclear whether the causes of cough in immunocompromised patients who are deemed unlikely to have a life-threating condition and a normal or un- changed chest radiograph are similar to those in persons with cough and normal immune systems. METHODS: We conducted a systematic review to answer the question: What are the most common causes of cough in ambulatory immunode?cient adults with normal chest radio- graphs?Studiesofpatients$ 18years ofagewithimmunede?ciency, cough ofany duration, and normal

2017 American College of Chest Physicians

37. The effect of pH on citric acid cough challenge: A randomised control trial in chronic cough and healthy volunteers. (PubMed)

The effect of pH on citric acid cough challenge: A randomised control trial in chronic cough and healthy volunteers. Citric acid has been used for over six decades to induce cough; however the mechanism of its pro-tussive effect is still not fully understood. We assessed the response to inhalation of citric acid at varying levels of acidity to determine if the pH of the solution plays a role in the induction of cough. Data was collected from both healthy volunteers and patients with chronic (...) cough.20 chronic cough patients and 20 healthy volunteers were recruited and underwent three cough challenges on separate days. Each visit involved 5 repeated one second inhalations of 300 mM citric acid solution. The concentration of the citrate cation remained constant, but the pH of the solution altered by the addition of sodium bicarbonate to 3, 5 and 6, representing the pKa values of the individual acid moieties. The total number of coughs elicited was recorded for each inhalation.Two subjects

2018 Respiratory physiology & neurobiology

38. Estimation of Cough Peak Flow Using Cough Sounds (PubMed)

Estimation of Cough Peak Flow Using Cough Sounds Cough peak flow (CPF) is a measurement for evaluating the risk of cough dysfunction and can be measured using various devices, such as spirometers. However, complex device setup and the face mask required to be firmly attached to the mouth impose burdens on both patients and their caregivers. Therefore, this study develops a novel cough strength evaluation method using cough sounds. This paper presents an exponential model to estimate CPF from (...) the cough peak sound pressure level (CPSL). We investigated the relationship between cough sounds and cough flows and the effects of a measurement condition of cough sound, microphone type and participant's height and gender on CPF estimation accuracy. The results confirmed that the proposed model estimated CPF with a high accuracy. The absolute error between CPFs and estimated CPFs were significantly lower when the microphone distance from the participant's mouth was within 30 cm than when the distance

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2018 Sensors (Basel, Switzerland)

39. Prevalence of Arnold nerve reflex in subjects with and without chronic cough: Relevance to Cough Hypersensitivity Syndrome. (PubMed)

Prevalence of Arnold nerve reflex in subjects with and without chronic cough: Relevance to Cough Hypersensitivity Syndrome. Cough is induced by stimulation of structures innervated by the vagus nerve, including the upper and lower airways and distal esophagus. The Arnold nerve reflex describes cough resulting from stimulation of the external auditory canal, which is innervated by the auricular branch of the vagus. We have recently reported the increased prevalence of this reflex in adults (...) , but not children, with chronic cough, relative to healthy adult and pediatric subjects. The prevalence of the Arnold nerve reflex in patients with pulmonary disease but without chronic cough has not been investigated previously.Three hundred adults and 100 children with chronic cough, 50 adults with stable pulmonary disease but without chronic cough, as well as 100 adult and 100 pediatric volunteers, underwent evaluation consisting of stimulation of the external auditory canal of each ear with a cotton-tipped

2018 Pulmonary Pharmacology & Therapeutics

40. Assessing referral and practice patterns of patients with chronic cough referred for behavioral cough suppression therapy. (PubMed)

Assessing referral and practice patterns of patients with chronic cough referred for behavioral cough suppression therapy. The purpose of this exploratory research was to describe current referral and practice patterns for behavioral cough suppression therapy (BCST) throughout the United States, and to assess the need for improving the efficiency of BCST referral patterns. In study I, 126 speech-language pathologists, who treat patients with refractory chronic cough (RCC) in the United States (...) , completed a survey about referral patterns, cough duration, and patient frustration level. In study II, 36 adults with RCC referred for BCST completed a four-part survey about cough symptoms and treatment. The survey included the Leicester Cough Questionnaire (LCQ) before and after BCST. Study I revealed significant patient frustration about the treatment process and the wait-time for BCST. Participants in study II reported average cough duration of over 2 years before BCST. Twenty-seven of 31

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2018 Chronic respiratory disease

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