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21. Cough Due to Tuberculous and Other Chronic Infections

Cough Due to Tuberculous and Other Chronic Infections Cough Due to TB and Other Chronic Infections CHEST Guideline and Expert Panel Report Stephen K. Field, MD,CM, FCCP; Patricio Escalante, MD, FCCP; Dina A. Fisher, MD, FCCP; Belinda Ireland, MD; Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel BACKGROUND: Cough is common in pulmonary TB and other chronic respiratory infections. Identifying features that predict whether pulmonary TB is the cause would help target (...) in February 2016. An updated KQ 2 search was undertaken in March 2017. RESULTS: Even where TB prevalence is greatest, most individuals with cough do not have pulmonary TB. There was no evidence that 1, 3, or 4 weeks’ duration were better predictors than cough lasting $ 2 weeks to screen for pulmonary TB. In people living with HIV (PLWHIV), screening for fever, night sweats, hemoptysis, and/or weight loss in addition to cough(any WorldHealthOrganization[WHO]-endorsed symptom)increasesthediagnostic

2018 American College of Chest Physicians

22. Classification of Cough as a Symptom in Adults and Management Algorithms

Classification of Cough as a Symptom in Adults and Management Algorithms Classi?cation of Cough as a Symptom in Adults and Management Algorithms CHEST Guideline and Expert Panel Report Richard S. Irwin, MD, Master FCCP; Cynthia L. French, PhD, RN, ANP-BC, FCCP; Anne B. Chang, MBBS, PhD, MPH; Kenneth W. Altman, MD, PhD; on behalf of the CHEST Expert Cough Panel* BACKGROUND: We performed systematic reviews using the population, intervention, com- parison, outcome (PICO) format to answer (...) the following key clinical question: Are the CHEST 2006 classi?cations of acute, subacute and chronic cough and associated manage- ment algorithms in adults that were based on durations of cough useful? METHODS:WeusedtheCHESTExpertCoughPanel’sprotocolforthesystematicreviewsand the American College of Chest Physicians (CHEST) methodological guidelines and Grading of Recommendations Assessment, Development, and Evaluation framework. Data from

2018 American College of Chest Physicians

23. Treating Cough Due to Non-CF and CF Bronchiectasis With Nonpharmacological Airway Clearance: CHEST Expert Panel Report

Treating Cough Due to Non-CF and CF Bronchiectasis With Nonpharmacological Airway Clearance: CHEST Expert Panel Report Treating Cough Due to Non-CF and CF Bronchiectasis With Nonpharmacological Airway Clearance CHEST Expert Panel Report Adam T. Hill, MD; Alan F. Barker, MD, FCCP; Donald C. Bolser, PhD; Paul Davenport, PhD; Belinda Ireland, MD; Anne B. Chang, MBBS, PhD, MPH; Stuart B. Mazzone, PhD; and Lorcan McGarvey, MD BACKGROUND: Inbronchiectasisduetocystic?brosis(CF)andothercauses (...) ,airwayclearanceis oneofthemainstaysofmanagement.Weconductedasystematicreviewonairwayclearanceby using non-pharmacological methods as recommended by international guidelines to develop recommendations or suggestions to update the 2006 CHEST guideline on cough. METHODS: The systematic search for evidence examined the question, “Is there evidence of clinically important treatment effects for non-pharmacological therapies in cough treatment for patients with bronchiectasis?” Populations selected were all patients

2018 American College of Chest Physicians

24. Subfreezing air as a cough trigger and multiple triggers are strongly associated with the presence of asthma in chronic cough. (Abstract)

Subfreezing air as a cough trigger and multiple triggers are strongly associated with the presence of asthma in chronic cough. Management of chronic cough relies on the recognition of cough background disorders. It is not known whether certain cough triggers are associated with specific background disorders.This was an e-mail study to public service employees of two towns in Finland. The questionnaire included twelve triggers. Current asthma was defined as doctor's diagnosis of asthma (...) and current wheezing. Chronic rhinosinusitis was defined as either nasal blockage or nasal discharge and either facial pain/pressure or reduction/loss of smell for more than three months. Gastroesophageal reflux disease was defined as heartburn and/or regurgitation on at least one day a week during the last three months. Idiopathic cough was defined as absence of any of them.There were 421 subjects with current cough that had lasted at least eight weeks. Subfreezing air as a cough trigger was associated

2019 Respiratory medicine

25. Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough. Full Text available with Trip Pro

Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough. The differential sensitivity of cough to antitussive therapies implies the existence of heterogeneity in cough hypersensitivity, but how such heterogeneity is expressed across individual patients is poorly understood. We investigated the phenotypes of cough hypersensitivity by examining transient receptor potential ankyrin 1 (TRPA1)- and transient receptor potential vanilloid 1 (TRPV1 (...) )-mediated cough sensitivity in patients with chronic refractory cough.Using a selective TRPA1 agonist, allyl isothiocyanate (AITC), we established an AITC cough challenge as a measure of TRPA1-mediated cough sensitivity. The AITC cough challenge and the widely used capsaicin (a selective TRPV1 agonist) cough challenge were performed with 250 patients with chronic refractory cough and 56 healthy subjects. The concentration of AITC or capsaicin solution causing at least two (C2) and five coughs (C5

2019 Respiratory research

26. Typical symptoms and not positive reflux-cough correlation predict cure of gastroesophageal reflux disease related chronic cough after laparoscopic fundoplication: a retrospective study. Full Text available with Trip Pro

Typical symptoms and not positive reflux-cough correlation predict cure of gastroesophageal reflux disease related chronic cough after laparoscopic fundoplication: a retrospective study. The effect of laparoscopic fundoplication on reflux-related chronic cough is unpredictable, the aim of the study is to investigate the predictive effect of positive reflux-cough correlation on the resolution of reflux-related chronic cough after anti-reflux surgery.A 5 years retrospective review was performed (...) . Logistic regression analysis was used to determine the independent predictors on the cure of chronic cough.Seventy-nine patients were included in this study, among which chronic cough was cured in 47 (59.5%) and significantly improved in 10 (12.7%) patients. Present of typical symptoms (odds ratio = 6.435,95% confidence interval [CI] = 1.427-29.032, p = 0.015) and number of Reflux episodes (impedance) ≥73 (odds ratio = 0.306, 95% confidence interval [CI] = 0.107-0.874, p = 0.027) were significantly

2019 BMC Gastroenterology

27. Cough presentation in primary care and the identification of chronic cough: a need for diagnostic clarity? (Abstract)

Cough presentation in primary care and the identification of chronic cough: a need for diagnostic clarity? Objective: To investigate patterns of presentation of cough in primary care and develop an algorithm to identify probable and possible chronic cough (CC). Methods: This retrospective observational study used routine English primary care data and linked hospital data. Patients with ≥1 cough event in the study period (March 2014-February 2015) were selected. Index date (...) was that of the earliest cough event in this period. Adults (aged ≥18 years) were classified as having probable CC if they had an explicit CC diagnosis; as having possible CC if they had ≥3 cough events recorded over 8-26 weeks; or, otherwise, as having acute cough. Underlying conditions associated with CC were identified. Results: 198,151 people were identified. 56.5% were female; median age was 47.0 years. The prevalence of cough in the study year was 17.6%. Of the 150,213 identified adults, 1600 (1.1%), 10,913 (7.3

2019 Current medical research and opinion

28. An Open-Label, Multi-Institutional, Randomized Study to Evaluate the Additive Effect of a Leukotriene Receptor Antagonist on Cough Score in Patients with Cough-Variant Asthma Being Treated with Inhaled Corticosteroids. (Abstract)

An Open-Label, Multi-Institutional, Randomized Study to Evaluate the Additive Effect of a Leukotriene Receptor Antagonist on Cough Score in Patients with Cough-Variant Asthma Being Treated with Inhaled Corticosteroids. Cough-variant asthma is one of the most common reasons for chronic cough. It is important to treat appropriately cough-variant asthma because 30% to 40% of cough-variant asthma becomes a typical asthma. However, little is known about the treatment of cough-variant asthma except (...) for inhaled corticosteroid (ICS). The aim of this study was to validate the additive efficacy of a leukotriene receptor antagonist (LTRA) on cough score and respiratory function in patients with cough-variant asthma being treated with ICS. A total 28 patients were randomly assigned to either an ICS + LTRA group or an ICS group. There were statistically significant improvements in cough scores in the ICS + LTRA group from 0 weeks (6.7 ± 4.4) to 2 weeks (2.9 ± 3.2) (P < 0.05), 4 weeks (0.7 ± 1.1) (P < 0.001

2019 The Kobe journal of medical sciences Controlled trial quality: uncertain

29. Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study. Full Text available with Trip Pro

Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study. The purpose of this prospective, quasi-experimental, single cohort proof-of-concept study was to determine feasibility and proof-of-concept of programmatically decreasing cough sensitivity through use of cough suppression strategies following inhalation of aerosolized capsaicin, in gradually increasing doses, across repeated treatment sessions.Five healthy adults (...) , ages 20-32 years of age, enrolled and completed the study. The study commenced in three phases. Phase I consisted of baseline cough sensitivity testing using pharmaceutical-grade aerosolized capsaicin, delivered via a Koko DigiDoser with nebulizer. The single-inhale, dose-response method was used. Doses that elicited two coughs (C2) and five coughs (C5) were recorded. Testing ceased when participants met the C5 threshold or when they had been given the maximum dose of 1,000 µmol/L. Phase II

2019 Annals of Translational Medicine Controlled trial quality: uncertain

30. Clinical validation of efficacy and safety of herbal cough formulation "Honitus syrup" for symptomatic relief of acute non-productive cough and throat irritation. Full Text available with Trip Pro

Clinical validation of efficacy and safety of herbal cough formulation "Honitus syrup" for symptomatic relief of acute non-productive cough and throat irritation. Acute cough represents the most common illness evaluated in the outpatient settings. Available remedies for its management are generally allopathic combinations of antihistamines and decongestants that achieve antitussive activity, but often with unpleasant side effects prompting the need to explore safer and effective options (...) . Honitus is an Ayurvedic proprietary herbal cough syrup with benefits of honey, intended to provide relief in acute nonproductive cough and throat irritation without causing drowsiness. This study investigated the safety and efficacy of Honitus in reducing acute nonproductive cough and throat irritation in comparison to a standard marketed allopathic cough syrup intended for use in similar conditions.This was a randomized double-blind study conducted in 105 individuals who received orally 2 tsp (10 ml

2019 Ayu Controlled trial quality: uncertain

31. Quantifying test-retest variability of natural and suppressed citric acid cough thresholds and urge to cough ratings. (Abstract)

Quantifying test-retest variability of natural and suppressed citric acid cough thresholds and urge to cough ratings. The citric acid cough reflex test (CRT) is used to quantify cough sensitivity and evaluate the effects of cough therapies and antitussive medications. This study quantifies the test-retest variability of natural and suppressed citric acid cough thresholds and urge to cough ratings in healthy individuals.Healthy adults (n = 16) inhaled increasing concentrations of citric acid (...) (0.01-3.2 mol/L) on three alternate days (1, 3, 5) until C2 cough thresholds (i.e. two consecutive coughs within 3 s) or the highest concentrations of citric acid was reached. Participants were instructed to "cough if you need to" in the natural cough condition, and "try not to cough" in the suppressed cough condition. Following each inhalation, participants were asked to rate their urge to cough (UTC) using a modified Borg Scale.Natural cough thresholds (NCTs) increased across days 1-3 (0.87

2019 Pulmonary Pharmacology & Therapeutics

32. Impaired cough suppression in chronic refractory cough. (Abstract)

Impaired cough suppression in chronic refractory cough. Functional brain imaging in individuals with chronic cough demonstrates reduced activation in cortical regions associated with voluntary cough suppression. Little is known about the ability of patients with chronic cough to suppress cough. This study aimed to compare the ability to voluntarily suppress cough during inhaled capsaicin challenge in participants with chronic refractory cough with that in healthy controls. This study also aimed (...) to assess the repeatability of capsaicin challenge test with voluntary cough suppression.Participants with chronic refractory cough and healthy controls underwent inhaled capsaicin challenge tests whilst attempting to suppress their cough responses. After 5 days either a conventional capsaicin challenge test with no cough suppression attempt, or a repeat test with an attempt at cough suppression was performed. Threshold capsaicin concentrations required to elicit 1, 2 and 5 coughs were calculated

2019 European Respiratory Journal

33. [Fractional exhaled nitric oxide measurement in patients with asthma and chronic cough]

[Fractional exhaled nitric oxide measurement in patients with asthma and chronic cough] [Fractional exhaled nitric oxide measurement in patients with asthma and chronic cough] [Fractional exhaled nitric oxide measurement in patients with asthma and chronic cough] Virgilio S, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation Virgilio S, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A. [Fractional exhaled nitric oxide measurement in patients with asthma and chronic cough] Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Documentos de Evaluación de Tecnologías Sanitarias, Informe de Respuesta Rapida No 536. 2017 Authors' conclusions Moderate quality evidence suggests that fractional exhaled

2017 Health Technology Assessment (HTA) Database.

34. ERS guidelines on the diagnosis and treatment of chronic cough in adults and children Full Text available with Trip Pro

ERS guidelines on the diagnosis and treatment of chronic cough in adults and children ERS Guidelines on the Diagnosis and Treatment of Chronic Cough in Adults and Children - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health U.S. National Library (...) Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation Eur Respir J Actions , 55 (1) 2020 Jan 2 ERS Guidelines on the Diagnosis and Treatment of Chronic Cough in Adults and Children , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Respiratory Research Group, Hull York Medical School, University of Hull, Hull, UK a.h.morice@hull.ac.uk. 2 Dept of Internal Medicine/Respiratory Medicine and Allergology

2020 EvidenceUpdates

35. Comparison of a Protective Cough Syrup Against Placebo on Night Cough in Children 1-5 Years Coughing Since 1- 2 Days Due to Common Cold

Comparison of a Protective Cough Syrup Against Placebo on Night Cough in Children 1-5 Years Coughing Since 1- 2 Days Due to Common Cold Comparison of a Protective Cough Syrup Against Placebo on Night Cough in Children 1-5 Years Coughing Since 1- 2 Days Due to Common Cold - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning (...) You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Comparison of a Protective Cough Syrup Against Placebo on Night Cough in Children 1-5 Years Coughing Since 1- 2 Days Due to Common Cold The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider

2017 Clinical Trials

36. Management of children with chronic wet cough and protracted bacterial bronchitis: CHEST guideline and Expert Panel report.

Management of children with chronic wet cough and protracted bacterial bronchitis: CHEST guideline and Expert Panel report. Management of children with chronic wet cough and protracted bacterial bronchitis: CHEST guideline and Expert Panel report. | National Guideline Clearinghouse success fail JUN 10 2017 2018 2019 14 Apr 2018 - 13 Jul 2018 COLLECTED BY Organization: Formed in 2009, the Archive Team (not to be confused with the archive.org Archive-It Team) is a rogue archivist collective (...) of children with chronic wet cough and protracted bacterial bronchitis: CHEST guideline and Expert Panel report. Chang AB, Oppenheimer JJ, Weinberger MM, Rubin BK, Grant CC, Weir K, Irwin RS, CHEST Expert Cough Panel. Management of children with chronic wet cough and protracted bacterial bronchitis: CHEST guideline and Expert Panel report. Chest. 2017 Apr;151(4):884-90. [33 references] This is the current release of the guideline. This guideline updates a previous version: Chang AB, Glomb WB. Guidelines

2017 National Guideline Clearinghouse (partial archive)

37. Use of management pathways or algorithms in children with chronic cough: CHEST guideline and Expert Panel report.

Use of management pathways or algorithms in children with chronic cough: CHEST guideline and Expert Panel report. Use of management pathways or algorithms in children with chronic cough: CHEST guideline and Expert Panel report. | National Guideline Clearinghouse success fail JUN 09 2017 2018 2019 14 Apr 2018 - 12 Jul 2018 COLLECTED BY Organization: Formed in 2009, the Archive Team (not to be confused with the archive.org Archive-It Team) is a rogue archivist collective dedicated to saving (...) of management pathways or algorithms in children with chronic cough: CHEST guideline and Expert Panel report. Chang AB, Oppenheimer JJ, Weinberger MM, Rubin BK, Weir K, Grant CC, Irwin RS, CHEST Expert Cough Panel. Use of management pathways or algorithms in children with chronic cough: CHEST guideline and Expert Panel report. Chest. 2017 Apr;151(4):875-83. [48 references] This is the current release of the guideline. This guideline meets NGC's 2013 (revised) inclusion criteria. Age Group UMLS Concepts

2017 National Guideline Clearinghouse (partial archive)

38. Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer

Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer CHEST Guideline and Expert Panel Report Alex Molassiotis, RN, PhD; Jaclyn A. Smith, MBChB, PhD; Peter Mazzone, MD, MPH; Fiona Blackhall, MD, PhD; and Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel BACKGROUND: Cough among patients with lung cancer is a common but often undertreated symptom. We used a 2015 Cochrane systematic (...) review, among other sources of evidence, to update the recommendations and suggestions of the American College of Chest Physicians (CHEST) 2006 guideline on this topic. METHODS: The CHEST methodologic guidelines and the Grading of Recommendations, Assessment, Development, and Evaluation framework were used. The Expert Cough Panel based their recommendations on data from the Cochrane systematic review on the topic, uncontrolled studies, case studies, and the clinical context. Final grading was reached

2017 American College of Chest Physicians

39. Cough in Ambulatory Immunocompromised Adults

Cough in Ambulatory Immunocompromised Adults CoughinAmbulatoryImmunocompromised Adults CHEST Expert Panel Report Mark J. Rosen, MD, Master FCCP; Belinda Ireland, MD; Mangala Narasimhan, DO, FCCP; Cynthia French, PhD, FCCP; Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel BACKGROUND: Cough is a common symptom prompting patients to seek medical care. Like patients in the general population, patients with compromised immune systems also seek care for cough. However (...) , it is unclear whether the causes of cough in immunocompromised patients who are deemed unlikely to have a life-threating condition and a normal or un- changed chest radiograph are similar to those in persons with cough and normal immune systems. METHODS: We conducted a systematic review to answer the question: What are the most common causes of cough in ambulatory immunode?cient adults with normal chest radio- graphs?Studiesofpatients$ 18years ofagewithimmunede?ciency, cough ofany duration, and normal

2017 American College of Chest Physicians

40. Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold

Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold CHEST Expert Panel Report MarkA.Malesker,PharmD,FCCP;PriscillaCallahan-Lyon,MD;BelindaIreland,MD;RichardS.Irwin,MD;MasterFCCP; on behalf of the CHEST Expert Cough Panel BACKGROUND: Acute cough associated with the common cold (CACC) causes signi?cant impairment in quality of life. Effective treatment approaches (...) . CONCLUSIONS: The evidence supporting the management of CACC is overall of low quality. This document provides treatment suggestions based on the best currently available evidence and identi?es gaps in our knowledge and areas for future research. CHEST 2017; 152(5):1021-1037 KEYWORDS: acute cough; common cold; pharmacologic and nonpharmacologic treatment ABBREVIATIONS: CACC = cough associated with the common cold; CHEST = American College of Chest Physicians; FDA = Food and Drug Administration; NSAID

2017 American College of Chest Physicians

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