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22901. Longitudinal decline in pulmonary function in atopic cough and cough variant asthma. (Abstract)

Longitudinal decline in pulmonary function in atopic cough and cough variant asthma. Cough variant asthma and atopic cough are different clinical manifestations of eosinophilic airway inflammation presenting with isolated chronic non-productive cough. The aim of this study was to examine the longitudinal change in pulmonary function in cough variant asthma and atopic cough.Longitudinal change in FEV1 was prospectively examined in 20 patients with cough variant asthma, 14 patients with atopic (...) cough and 271 asymptomatic healthy subjects. All were lifetime non-smokers. Of the 20 cough variant asthma patients, 13 were taking long-term inhaled corticosteroid therapy (ICS) (beclomethasone dipropionate 615 +/- 58 micro g/day) and the other seven were not. Spirometry was taken at first visit, after cough was almost completely relieved on therapy, and at least once every year for 5 or more years afterwards.The slope of longitudinal change in FEV1 was not significantly different among cough

2003 Clinical and Experimental Allergy

22902. Candesartan Cilexetil is not Associated with Cough in Patients with Enalapril-induced Cough. (Abstract)

Candesartan Cilexetil is not Associated with Cough in Patients with Enalapril-induced Cough. Treatment with angiotensin-converting enzyme (ACE) inhibitors is frequently associated with persistent dry cough. This side effect is thought to be due to the non-specific action of ACE inhibitors, which, in addition to suppressing the renin-angiotensin system (RAS), leads to the accumulation of kinins, encephalins and other biologically active peptides. Candesartan cilexetil is a new, long-acting (...) angiotensin II type 1 (AT 1 ) receptor blocker, which offers a more specific means of suppressing the RAS than can be achieved with ACE inhibitors. In this study, we compared the incidence and severity of cough during treatment with candesartan cilexetil, enalapril and placebo in patients with hypertension and enalapril-induced cough. Men and women, aged 20-80 years, with a history of medically treated primary hypertension and ACE-inhibitor-related cough were enrolled. The presence of cough was confirmed

2000 Blood pressure Controlled trial quality: uncertain

22903. A Comparison of the Cough Profile of Fosinopril and Enalapril in Hypertensive Patients with a History of ACE Inhibitor-Associated Cough. (Abstract)

A Comparison of the Cough Profile of Fosinopril and Enalapril in Hypertensive Patients with a History of ACE Inhibitor-Associated Cough. OBJECTIVE: Cough frequency and severity with fosinopril and enalapril were assessed in hypertensive patients with previous angiotensin-converting enzyme inhibitor (ACEI)-associated cough. DESIGN: Prospective, multicenter, randomized, 8-week double-blind treatment. PATIENTS: One hundred seventy-nine patients (mild-to-moderate hypertension, nonsmokers, mean age (...) 58 years; 55% females; 72% Caucasian, 6% black, 19% Hispanic) were studied. Patients with other cough etiologies, significant co-morbidity, or confounding medications were excluded. INTERVENTIONS: Patients were randomized to fosinopril 10 mg (n = 85) or enalapril 5 mg (n = 94) once daily. Dosage could be doubled for blood pressure control after 4 weeks. Outcome measurements: The primary end point was all-cough frequency based on patient daily diary ratings; a cumulative cough frequency score

1995 American journal of therapeutics Controlled trial quality: uncertain

22904. Severe nonproductive cough and cough-induced stress urinary incontinence in diabetic postmenopausal women treated with ACE inhibitor. (Abstract)

Severe nonproductive cough and cough-induced stress urinary incontinence in diabetic postmenopausal women treated with ACE inhibitor. 10868884 2000 10 03 2013 11 21 0149-5992 23 3 2000 Mar Diabetes care Diabetes Care Severe nonproductive cough and cough-induced stress urinary incontinence in diabetic postmenopausal women treated with ACE inhibitor. 427-8 Lee Y J YJ Chiang Y F YF Tsai J C JC eng Clinical Trial Letter Randomized Controlled Trial Research Support, Non-U.S. Gov't United States (...) Diabetes Care 7805975 0149-5992 0 Angiotensin-Converting Enzyme Inhibitors JMS50MPO89 Losartan Y5GMK36KGY Perindopril IM Angiotensin-Converting Enzyme Inhibitors adverse effects Cough chemically induced epidemiology Diabetic Angiopathies complications drug therapy physiopathology Double-Blind Method Female Humans Hypertension complications drug therapy Losartan adverse effects Perindopril adverse effects Postmenopause Prevalence Prospective Studies Urinary Incontinence, Stress etiology 2000 6 27 11 0

2000 Diabetes Care Controlled trial quality: uncertain

22905. Assessment of the antitussive efficacy of codeine using cough sound pressure levels as a means of measuring cough. (Abstract)

Assessment of the antitussive efficacy of codeine using cough sound pressure levels as a means of measuring cough. 9232676 1997 08 25 2013 11 21 0952-0600 9 5-6 1996 Oct-Dec Pulmonary pharmacology Pulm Pharmacol Assessment of the antitussive efficacy of codeine using cough sound pressure levels as a means of measuring cough. 365 Freestone C C Common Cold Centre, School of Molecular and Medical Biosciences, University of Wales College Cardiff, U.K. Eccles R R Morris S S Jawad M S MS eng Clinical (...) Trial Journal Article Randomized Controlled Trial England Pulm Pharmacol 9007551 0952-0600 Q830PW7520 Codeine IM Adolescent Adult Codeine therapeutic use Cough drug therapy physiopathology Double-Blind Method Female Humans Male Middle Aged Outcome Assessment (Health Care) Sound Spectrography 1996 10 1 1996 10 1 0 1 1996 10 1 0 0 ppublish 9232676 S0952-0600(96)90048-4

1997 Pulmonary Pharmacology Controlled trial quality: uncertain

22906. Cough challenge in the assessment of cough reflex Full Text available with Trip Pro

Cough challenge in the assessment of cough reflex 11678780 2001 12 18 2018 11 13 0306-5251 52 4 2001 Oct British journal of clinical pharmacology Br J Clin Pharmacol Cough challenge in the assessment of cough reflex. 365-75 Morice A H AH Academic Department of Medicine, Respiratory Medicine, University of Hull, Castle Hill Hospital, Castle Road, Cottingham HU16 5JQ. a.h.morice@medschool.hull.ac.uk Kastelik J A JA Thompson R R eng Journal Article Review England Br J Clin Pharmacol 7503323 0306 (...) -5251 0 Antitussive Agents 2968PHW8QP Citric Acid S07O44R1ZM Capsaicin IM Animals Antitussive Agents therapeutic use Capsaicin administration & dosage adverse effects Citric Acid administration & dosage adverse effects Clinical Trials as Topic Cough chemically induced drug therapy Humans Nebulizers and Vaporizers Reflex drug effects 102 2001 10 27 10 0 2002 1 5 10 1 2001 10 27 10 0 ppublish 11678780 1475 PMC2014577 Thorax. 1985 Sep;40(9):662-7 2932814 Pulm Pharmacol. 1996 Oct-Dec;9(5-6):389-92

2001 British journal of clinical pharmacology

22907. Should we advise parents to administer over the counter cough medicines for acute cough? Systematic review of randomised controlled trials Full Text available with Trip Pro

Should we advise parents to administer over the counter cough medicines for acute cough? Systematic review of randomised controlled trials Should we advise parents to admin... preview & related info | Mendeley Papers People Groups Search Search Search Journal Article OPEN ACCESS Should we advise parents to administer over the counter cough medicines for acute cough? Systematic review of randomised controlled trials Archives of Disease in Childhood (2002) 86(3) 170-175 DOI: 63 Citations (...) Citations of this article 28 Readers Mendeley users who have this article in their library. Add to library Sign in to view PDF Abstract AIMS: To determine the effectiveness of over the counter (OTC) cough medicines for acute cough in children. METHODS: Systematic review of randomised controlled trials (RCTs). An all language search of the Cochrane Acute Respiratory Infections Group specialised register, Cochrane Controlled Trials Register, Medline, Embase, and the UK Department of Health National

2002 Archives of Disease in Childhood

22908. Effect of manually assisted cough and mechanical insufflation on cough flow of normal subjects, patients with chronic obstructive pulmonary disease (COPD), and patients with respiratory muscle weakness Full Text available with Trip Pro

Effect of manually assisted cough and mechanical insufflation on cough flow of normal subjects, patients with chronic obstructive pulmonary disease (COPD), and patients with respiratory muscle weakness It has been suggested that cough effectiveness can be improved by assisted techniques. The effects of manually assisted cough and mechanical insufflation on cough flow physiology are reported in this study.The physiological actions and patient self-assessment of manually assisted cough (...) and mechanical insufflation were investigated in 29 subjects (nine normal subjects, eight patients with chronic obstructive pulmonary disease (COPD), four subjects with respiratory muscle weakness (RMW) with scoliosis, and eight subjects with RMW without scoliosis).The peak cough expiratory flow rate and cough expiratory volume were not improved by manually assisted cough and mechanical insufflation alone or in combination in normal subjects. The median increase in peak cough expiratory flow in subjects

2001 Thorax

22909. Over the counter cough medicines for acute cough : The fact that people keep buying the medicines is itself evidence Full Text available with Trip Pro

Over the counter cough medicines for acute cough : The fact that people keep buying the medicines is itself evidence 12003902 2002 05 31 2018 11 13 1756-1833 324 7346 2002 May 11 BMJ (Clinical research ed.) BMJ Over the counter cough medicines for acute cough. The fact that people keep buying the medicines is itself evidence. 1158 Walmsley James J Marshall Graham G eng Comment Letter England BMJ 8900488 0959-8138 0 Antitussive Agents 0 Nonprescription Drugs AIM IM BMJ. 2002 Feb 9;324(7333):329 (...) -31 11834560 BMJ. 2002 May 11;324(7346):1158 12008729 Acute Disease Antitussive Agents therapeutic use Cough drug therapy Evidence-Based Medicine Humans Nonprescription Drugs therapeutic use Practice Guidelines as Topic 2002 5 11 10 0 2002 6 1 10 1 2002 5 11 10 0 ppublish 12003902 PMC1123112 Chest. 2001 Oct;120(4):1121-8 11591548 BMJ. 2002 Feb 9;324(7333):329-31 11834560 Eur Respir J. 2002 Jan;19(1):6-7 11843328

2002 BMJ : British Medical Journal

22910. Cough sensitivity in children with asthma, recurrent cough, and cystic fibrosis Full Text available with Trip Pro

Cough sensitivity in children with asthma, recurrent cough, and cystic fibrosis In adults, cough sensitivity is influenced by gender and is heightened in those with non-productive cough. This study examined if cough sensitivity is (i) altered in children with asthma, recurrent cough, and cystic fibrosis and (ii) influenced by age, gender, or forced expiratory volume in one second (FEV1). Cough sensitivity to capsaicin and spirometry were performed on 209 children grouped by the diagnosis (...) of asthma, recurrent dry cough, cystic fibrosis, and controls. Cough sensitivity was increased in children with recurrent cough, and lower in children with cystic fibrosis when compared with children with asthma and controls. Age influenced cough sensitivity in the controls. In the asthmatics, FEV1 (% predicted) correlated to cough sensitivity measures. There was no gender difference in cough sensitivity. It is concluded that cough sensitivity is different among children with recurrent dry cough, asthma

1997 Archives of Disease in Childhood

22911. Cough threshold for capsaicin increases by azelastine in patients with cough-variant asthma. (Abstract)

Cough threshold for capsaicin increases by azelastine in patients with cough-variant asthma. To assess the effects of azelastine in patients with cough-variant asthma, we measured the cough threshold for capsaicin (the concentration required to elicit more than five coughs) in 16 patients with cough-variant asthma before and after 4 weeks of treatment with azelastine (2 mg; b.i.d.) or placebo. After treatment, coughing decreased in all patients and the cough threshold for capsaicin increased (...) significantly, from 0.67 +/- 0.30 microM to 4.76 +/- 1.55 microM (P < 0.01) in the azelastine group. However, the cough threshold for capsaicin did not increase significantly, from 0.86 +/- 0.33 microM to 1.11 +/- 0.35 microM (P > 0.10) in the placebo group. These results suggest that azelastine inhibits coughing in patients with cough-variant asthma.

1996 Pulmonary pharmacology

22912. Application and validation of a computerized cough acquisition system for objective monitoring of acute cough: a meta-analysis. (Abstract)

Application and validation of a computerized cough acquisition system for objective monitoring of acute cough: a meta-analysis. The purpose of the meta-analysis was to understand the antitussive effect of treatment with dextromethorphan hydrobromide, 30 mg, vs placebo over a 3-h treatment period in patients with cough due to uncomplicated upper respiratory tract infection (URTI), and to show that the computerized system for acquisition and analysis of cough sound was consistent and reproducible (...) across the individual studies.The six studies used for the meta-analysis were randomized, double-blind, parallel-group, single-dose, placebo-controlled studies with a 3-h postdose cough evaluation period.One study was conducted in Durban, South Africa, and five studies were conducted in Bombay, India. Four studies took place in clinics, and two studies were in-home studies.Seven hundred ten adult patients with cough due to uncomplicated URTI who were otherwise healthy and who satisfied the inclusion

2001 Chest

22913. Symptomatic treatment of the cough in whooping cough. (Abstract)

Symptomatic treatment of the cough in whooping cough. Whooping cough is an important cause of childhood morbidity and mortality. There are 20 to 40 million cases of whooping cough annually world-wide, 90% of which occur in developing countries, resulting in an estimated 200 to 300 000 fatalities each year. Much of the morbidity is due to the effects of the paroxysmal cough. Corticosteroids, salbutamol (beta 2 - adrenergic stimulant), and pertussis-specific immunoglobulin have been proposed (...) as standard treatment for the cough. Antihistamines have also been administered. No systematic review of the effectiveness of any of these interventions or others has been performed.To assess the effectiveness and safety of interventions used to reduce the severity of the coughing paroxysms in whooping cough in children and adults.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (issue 2, 2003); MEDLINE (January 1966 to June 2003); EMBASE (1990 to June 2003) and LILACS (1982

2003 Cochrane database of systematic reviews (Online)

22914. Randomized single-blind trial in general practice comparing the efficacy and palatability of two cough linctus preparations, 'Pholcolix' and 'Actifed' Compound, in children with acute cough. (Abstract)

Randomized single-blind trial in general practice comparing the efficacy and palatability of two cough linctus preparations, 'Pholcolix' and 'Actifed' Compound, in children with acute cough. Two hundred and seventeen patients between 6 and 12 years of age suffering from acute cough took part in a randomized, single-blind study comparing 'Pholcolix' and 'Actifed' Compound. No significant difference in efficacy was demonstrated but analysis of palatability components (taste, smell, aftertaste

1983 Current medical research and opinion Controlled trial quality: uncertain

22915. Bradykinin-induced cough reflex markedly increases in patients with cough associated with captopril and enalapril. (Abstract)

Bradykinin-induced cough reflex markedly increases in patients with cough associated with captopril and enalapril. We studied the effects of angiotensin converting enzyme (ACE) inhibitors on cough responses to bradykinin (BK), substance P (SP) and citric acid in a double blind, random study on 10 hypertensive patients receiving ACE inhibitors. Of these patients, five had reported cough with ACE inhibitors. Cough responses to citric acid were similar between patients with and without cough (...) , and SP up to 10(-5) M did not cause cough in any of the subjects. BK caused cough at 13.4 +/- 1.2 (-log M) in 5 patients with cough associated with ACE inhibitors, but it did not cause cough at concentrations up to 10(-5) M in other 5 patients. One month after the withdrawal of ACE inhibitors, 5 patients were free from cough symptoms, and BK did not cause cough up to 10(-5) M in these patients, except for one who coughed at 10(-9) M, without changes in responses to citric acid. BK caused cough

1991 The Tohoku journal of experimental medicine Controlled trial quality: uncertain

22916. The effect of sulindac on the abnormal cough reflex associated with dry cough. (Abstract)

The effect of sulindac on the abnormal cough reflex associated with dry cough. In order to determine the possible role of prostaglandins in the abnormal cough reflex in patients with dry cough, the effects of a cyclooxygenase inhibitor on cough symptoms were examined. This was measured by a cough symptom score and by the cough reflex sensitivity to inhaled capsaicin in a double blind, randomized, cross-over study comparing the effects of placebo with sulindac, 200 mg daily for 1 week. We (...) studied six hypertensive patients with angiotensin converting enzyme inhibitor-associated cough and six patients with an idiopathic, dry, unproductive cough, all of whom had an increase in the sensitivity of the cough reflex. There was no change in blood pressure control in the hypertensive patients during sulindac therapy. The patients with the angiotensin converting enzyme-associated cough had a significant reduction in the cough symptom score and also a significant increase in the dose of capsaicin

1990 The Journal of pharmacology and experimental therapeutics Controlled trial quality: uncertain

22917. ACE inhibitors, angiotensin II antagonists and cough. The Losartan Cough Study Group. (Abstract)

ACE inhibitors, angiotensin II antagonists and cough. The Losartan Cough Study Group. One hundred and thirty five non-smoking hypertensive patients with ACE inhibitor cough confirmed by lisinopril rechallenge and placebo dechallenge were recruited into a double-blind random parallel-group comparison of losartan 50 mg, lisinopril 20 mg and hydrochlorothiazide 25 mg each given once daily for a maximum of 8 weeks. The aim of the study was to compare the incidence of cough with the angiotensin II (...) antagonist losartan, the ACE inhibitor lisinopril and the hydrochlorothiazide in hypertensive patients with previous ACE inhibitor cough. Cough detected by self-administered questionnaire was the primary end-point, and cough frequency by visual analogue scale a secondary end-point. The incidence of cough with losartan (29%) was lower than that for lisinopril (72%, P < 0.01) and similar to that for hydrochlorothiazide (34%). Cough frequency by visual analogue scale was lower for losartan than lisinopril

1995 Journal of human hypertension Controlled trial quality: uncertain

22918. Effects of modulators of the renin-angiotensin-aldosterone system on cough. Losartan Cough Study Group. (Abstract)

Effects of modulators of the renin-angiotensin-aldosterone system on cough. Losartan Cough Study Group. To compare the incidence of cough in patients with a history of angiotensin converting enzyme (ACE) inhibitor-related cough who received losartan [a type 1 angiotensin II (Ang II) receptor antagonist], lisinopril (an ACE inhibitor) or hydrochlorothiazide (a diuretic).An international, multicentre, randomized double-blind, parallel-group controlled trial.Outpatient clinics at 20 tertiary care (...) medical centres in 11 countries.One hundred and thirty-five patients with uncomplicated primary hypertension with a history of ACE inhibitor-related cough were randomly assigned to the double-blind treatment phase and completed the study.After confirming that the cough was ACE inhibitor-related by a single-blind rechallenge, followed by a placebo washout period, patients were randomly assigned to receive 50mg losartan, 20mg lisinopril or 25mg hydrochlorothiazide once a day for 8 weeks.Cough incidence

1994 Journal of hypertension Controlled trial quality: predicted high

22919. [Effects of inhaled anticholinergic agents and beta 2-agonists on distilled water induced cough in patients with chronic cough]. (Abstract)

[Effects of inhaled anticholinergic agents and beta 2-agonists on distilled water induced cough in patients with chronic cough]. The purpose of this study was to evaluate the usefulness of ultrasonically nebulized distilled water (UNDW) inhalation for assessing cough receptor sensitivity and also the effects of inhaled anticholinergic agents and beta 2-agonists on the number of coughs induced by the UNDW inhalation in patients with chronic cough. All patients were non-smokers and had neither (...) bronchial hyperreactivity nor atopic status. We studied the effects of inhaled oxitropium bromide (300 micrograms) and fenoterol hydrobromide (600 micrograms) on the number of coughs induced by UNDW inhalation for 3 minutes in 9 patients with chronic cough and the effects of inhaled fenoterol hydrobromide (400 micrograms) on the number of coughs induced by UNDW inhalation for 1 minute in 8 patients with chronic cough using a randomized, double-blind, cross-over method. There was no significant

1996 Arerugī = [Allergy] Controlled trial quality: uncertain

22920. Effect of loratadine, an H1 antihistamine, on induced cough in non-asthmatic patients with chronic cough. Full Text available with Trip Pro

Effect of loratadine, an H1 antihistamine, on induced cough in non-asthmatic patients with chronic cough. H1 antihistamines have been shown to have an antitussive effect in patients with asthma, postnasal drip, and allergic rhinitis. No study has been performed to determine whether orally administered H1 antihistamines can reduce the number of coughs induced by stimulation of cough receptors in non-asthmatic patients with chronic dry cough.The effect of loratadine (10 mg) on the number (...) of coughs induced by ultrasonically nebulised distilled water (UNDW) was examined in 10 patients with nasal disease and in seven patients with unexplained chronic cough using a randomised, double blind crossover method. Eleven normal volunteers were also studied. Each subject inhaled UNDW for one minute, and the numbers of coughs during the one minute inhalation and the 30 seconds following it were counted.There was no difference in the results of pulmonary function tests performed before and one minute

1996 Thorax Controlled trial quality: uncertain

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