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Cough

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22861. Cough plate versus cough swab in patients with cystic fibrosis; a pilot study. Full Text available with Trip Pro

Cough plate versus cough swab in patients with cystic fibrosis; a pilot study. Accurate identification of lower respiratory tract pathogens is important in the management of cystic fibrosis patients.To evaluate the cough plate as an alternative method of obtaining respiratory samples for microbiological culture.Using sputum culture as the "gold standard", the cough plate method identified significantly more positive cases than either dry or moistened cough swabs. Of 20 patients who had (...) a positive sputum culture, 16 had a positive culture on cough plate compared to seven positive cultures each on moistened swab and on dry swab respectively.In this study cough plates were more sensitive than cough swabs in isolating respiratory pathogens in sputum producers. As patients prefer it, the cough plate merits further evaluation, particularly in non-sputum producers.

2004 Archives of disease in childhood Controlled trial quality: uncertain

22862. Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. (Abstract)

Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. To determine whether the commonly used over-the-counter medications dextromethorphan and diphenhydramine are superior to placebo for the treatment of nocturnal cough and sleep difficulty associated with upper respiratory infections and to determine whether parents have improved sleep quality when their children receive the medications when compared (...) with placebo.Parents of 100 children with upper respiratory infections were questioned to assess the frequency, severity, and bothersome nature of the nocturnal cough. Their answers were recorded on 2 consecutive days, initially on the day of presentation, when no medication had been given the previous evening, and then again on the subsequent day, when either medication or placebo was given before bedtime. Sleep quality for both the child and the parent were also assessed for both nights.For the entire cohort

2004 Pediatrics Controlled trial quality: uncertain

22863. Effectiveness of amitriptyline versus cough suppressants in the treatment of chronic cough resulting from postviral vagal neuropathy. Full Text available with Trip Pro

Effectiveness of amitriptyline versus cough suppressants in the treatment of chronic cough resulting from postviral vagal neuropathy. The objective of this prospective, randomized, controlled study (N = 28) was to evaluate the effectiveness of amitriptyline versus cough suppressants in the treatment of chronic cough resulting from postviral vagal neuropathy.Patients were selected based on a clinical history consistent with postviral vagal neuropathy and a history of an antecedent upper (...) respiratory tract infection. All patients had been tried on antireflux medication (proton pump inhibitors) and had a negative chest x-ray before presentation. All were nonsmokers without a history of asthma. Patients on angiotensin-converting enzyme inhibitors were excluded from the study. All patients completed a pretreatment, validated cough-specific quality-of-life (QOL) survey. Patients were randomized by chart numbers to either 10 mg amitriptyline at bedtime or 10 to 100 mg/5 mL, 10 mL codeine

2006 Laryngoscope Controlled trial quality: uncertain

22864. Acidification of the oesophagus acutely increases the cough sensitivity in patients with gastro-oesophageal reflux and chronic cough. (Abstract)

Acidification of the oesophagus acutely increases the cough sensitivity in patients with gastro-oesophageal reflux and chronic cough. Gastro-oesophageal reflux disease (GORD) is one of the most common causes of chronic cough; however, the mechanisms by which GOR initiates coughing are incompletely understood. We address the hypothesis that acidification of oesophagus acutely increases the cough reflex sensitivity in patients with GORD and chronic cough. Nine patients with GORD with chronic (...) cough and 16 patients with GORD without cough were recruited. In a randomized double blind study, saline and acid (HCl, 0.1 mol L(-1)) were separately infused into oesophagus via naso-oesophageal catheter. Cough reflex sensitivity to inhaled capsaicin was determined immediately after completion of each infusion. Infusion of acid into oesophagus increased capsaicin cough reflex sensitivity in patients with GORD and chronic cough. In contrast, acid had no effect on the cough sensitivity in patients

2008 Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Controlled trial quality: uncertain

22865. Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults. Full Text available with Trip Pro

Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults. To determine whether over the counter cough medicines are effective for acute cough in adults.Systematic review of randomised controlled trials.Search of the Cochrane Acute Respiratory Infections Group specialised register, Cochrane Controlled Trials Register, Medline, Embase, and the UK Department of Health National Research Register in all languages.All randomised controlled trials (...) that compared oral over the counter cough preparations with placebo in adults with acute cough due to upper respiratory tract infection in ambulatory settings and that had cough symptoms as an outcome.15 trials involving 2166 participants met all the inclusion criteria. Antihistamines seemed to be no better than placebo. There was conflicting evidence on the effectiveness of antitussives, expectorants, antihistamine-decongestant combinations, and other drug combinations compared with placebo.Over

2002 BMJ

22866. Validation of the Leicester Cough Monitor (LCM): preliminary findings using an automated cough detection system in patients with chronic cough. Full Text available with Trip Pro

Validation of the Leicester Cough Monitor (LCM): preliminary findings using an automated cough detection system in patients with chronic cough. Chronic cough is a common condition that presents to both primary and secondary care. Assessment and management are hampered by the absence of well-validated outcome measures. The present study comprises the validation of the Leicester Cough Monitor (LCM), an automated sound-based ambulatory cough monitor. Cough frequency was measured with the LCM (...) and compared with coughs and other sounds counted manually over 2 h of a 6-h recording by two observers in nine patients with chronic cough in order to determine the sensitivity and specificity of the LCM. Automated cough frequency was also compared with manual counts from one observer in 15 patients with chronic cough and eight healthy subjects. All subjects underwent 6-h recordings. A subgroup consisting of six control and five patients with stable chronic cough underwent repeat automated measurements

2008 European Respiratory Journal

22867. Chronic cough: how do cough reflex sensitivity and subjective assessments correlate with objective cough counts during ambulatory monitoring? Full Text available with Trip Pro

Chronic cough: how do cough reflex sensitivity and subjective assessments correlate with objective cough counts during ambulatory monitoring? Cough reflex sensitivity, subjective estimates of cough frequency and cough-related quality of life have been used to assess cough and monitor treatment responses. The relationships between these measures and objective cough monitoring remain unclear and the usefulness of subjective assessments remains questionable.62 patients with chronic cough (39 women (...) ) were studied. Mean age of patients was 54.9 (SD 12.2) years, with a median duration of cough of 5.5 (range 1-30) years.Cough reflex sensitivity testing (C5; citric acid) was performed in all patients before fully ambulatory day-time and night-time cough recordings. Patients scored the frequency and severity of their cough (Visual Analogue Scales (VAS) and 0-5 score) for each recording period and completed a cough-related quality-of-life questionnaire, Leicester Cough Questionnaire (LCQ). Ambulatory

2007 Thorax

22868. Habit cough, tic cough, and psychogenic cough in adult and pediatric populations: ACCP evidence-based clinical practice guidelines. (Abstract)

Habit cough, tic cough, and psychogenic cough in adult and pediatric populations: ACCP evidence-based clinical practice guidelines. To review the literature on habit, tic, and psychogenic cough, and to make evidence-based recommendations regarding diagnosis and treatment.For data on adults, an Ovid MEDLINE literature review (through February 2005) was performed for all studies published in the English language, including case series and case reports, since 1966 using the medical subject heading (...) terms "habit cough," "psychogenic cough," "tic disorder," "vocal tic," "Tourette's syndrome," "honking cough," and "barking cough." For pediatric data, articles were identified dating from 1966 from searches of the Cochrane Library, PubMed, EMBASE, the list of references in relevant publications, and the authors' collection of references with the last search performed in February 2005. The search terms used were "children" and "vocal tics" or "habit cough," or "psychogenic cough" or "chronic cough

2006 Chest

22869. Do directed cough maneuvers improve cough effectiveness in the early period after open heart surgery? Effect of thoracic support and maximal inspiration on cough peak expiratory flow, cough expiratory volume, and thoracic pain. (Abstract)

Do directed cough maneuvers improve cough effectiveness in the early period after open heart surgery? Effect of thoracic support and maximal inspiration on cough peak expiratory flow, cough expiratory volume, and thoracic pain. Directed cough maneuvers are often included in physiotherapy management aimed at preventing postoperative pulmonary complications after open heart surgery, but there is little scientific evidence of the effectiveness of directed cough maneuvers.We conducted a randomized (...) intra-subject crossover trial to evaluate the effect of thoracic support (patient holds his or her hands over the incision) and maximal inspiration on cough peak expiratory flow (CPEF), cough expiratory volume (CEV), and incision pain during cough in the early period after open heart surgery. Cough evaluation was undertaken on the first and second morning after surgery. On both measurement days the subject did a baseline cough (baseline cough 1) then, in a random sequence, performed 3 cough

2008 Respiratory care Controlled trial quality: uncertain

22870. Severe nonproductive cough and cough-induced stress urinary incontinence in diabetic postmenopausal women treated with ACE inhibitor. (Abstract)

Severe nonproductive cough and cough-induced stress urinary incontinence in diabetic postmenopausal women treated with ACE inhibitor. 10868884 2000 10 03 2013 11 21 0149-5992 23 3 2000 Mar Diabetes care Diabetes Care Severe nonproductive cough and cough-induced stress urinary incontinence in diabetic postmenopausal women treated with ACE inhibitor. 427-8 Lee Y J YJ Chiang Y F YF Tsai J C JC eng Clinical Trial Letter Randomized Controlled Trial Research Support, Non-U.S. Gov't United States (...) Diabetes Care 7805975 0149-5992 0 Angiotensin-Converting Enzyme Inhibitors JMS50MPO89 Losartan Y5GMK36KGY Perindopril IM Angiotensin-Converting Enzyme Inhibitors adverse effects Cough chemically induced epidemiology Diabetic Angiopathies complications drug therapy physiopathology Double-Blind Method Female Humans Hypertension complications drug therapy Losartan adverse effects Perindopril adverse effects Postmenopause Prevalence Prospective Studies Urinary Incontinence, Stress etiology 2000 6 27 11 0

2000 Diabetes Care Controlled trial quality: uncertain

22871. Assessment of the antitussive efficacy of codeine using cough sound pressure levels as a means of measuring cough. (Abstract)

Assessment of the antitussive efficacy of codeine using cough sound pressure levels as a means of measuring cough. 9232676 1997 08 25 2013 11 21 0952-0600 9 5-6 1996 Oct-Dec Pulmonary pharmacology Pulm Pharmacol Assessment of the antitussive efficacy of codeine using cough sound pressure levels as a means of measuring cough. 365 Freestone C C Common Cold Centre, School of Molecular and Medical Biosciences, University of Wales College Cardiff, U.K. Eccles R R Morris S S Jawad M S MS eng Clinical (...) Trial Journal Article Randomized Controlled Trial England Pulm Pharmacol 9007551 0952-0600 Q830PW7520 Codeine IM Adolescent Adult Codeine therapeutic use Cough drug therapy physiopathology Double-Blind Method Female Humans Male Middle Aged Outcome Assessment (Health Care) Sound Spectrography 1996 10 1 1996 10 1 0 1 1996 10 1 0 0 ppublish 9232676 S0952-0600(96)90048-4

1997 Pulmonary Pharmacology Controlled trial quality: uncertain

22872. Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ). Full Text available with Trip Pro

Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ). Chronic cough is a common condition which has a significant impact on quality of life. Assessment and management are hampered by the absence of well validated outcome measures. The development and validation of the Leicester Cough Questionnaire (LCQ), a self-completed health related quality of life measure of chronic cough, is presented.Patients with chronic cough were (...) recruited from outpatient clinics. The development of the LCQ consisted of three phases: phase 1 (item generation); phase 2 (item reduction, allocation of items to domains and validation of questionnaire); phase 3 (repeatability and responsiveness testing of final version of questionnaire).Phase 1: Literature review, multidisciplinary team meeting and 15 structured interviews with chronic cough patients generated 44 items (LCQ1) with a 7 point Likert response scale. Phase 2: 104 chronic cough

2003 Thorax

22873. Cough . 2: Chronic cough in children. Full Text available with Trip Pro

Cough . 2: Chronic cough in children. Chronic cough is a common problem in childhood. Viral infections are the most prevalent cause, but other rarer disorders should be excluded whenever cough appears unusually severe and/or frequent, and when there is evidence of failure to thrive and growth retardation. The younger the child, the more the need to exclude underlying disease at an early stage. Passive smoking is an important contributor to chronic cough in children. Chronic productive cough

2003 Thorax

22874. Cough. 3: chronic cough and gastro-oesophageal reflux. Full Text available with Trip Pro

Cough. 3: chronic cough and gastro-oesophageal reflux. The pathogenesis and clinical features of gastro-oesophageal reflux related cough are complex and the diagnostic tests available are of limited reliability. Treatment needs to be tailored to the specific needs of individual patients and other possible causes of chronic cough should be investigated. Treatment should only be considered to have failed when cough persists after administration of proton pump inhibitors at an adequate dosage

2003 Thorax

22875. Cough. 1: Chronic cough in adults. Full Text available with Trip Pro

Cough. 1: Chronic cough in adults. The investigation and treatment of chronic cough in adults is generally rewarding, provided there is an understanding of its aetiology, particularly when it arises from sites outside the respiratory tract.

2003 Thorax

22876. Sex-related differences in cough reflex sensitivity in patients with chronic cough. (Abstract)

Sex-related differences in cough reflex sensitivity in patients with chronic cough. Among patients attending specialist cough clinics there is an excess of females, but the reason for this sex difference is unknown. We tested the hypothesis that the sensitivity of the cough reflex is greater in female compared with male patients with chronic cough. Inhalation cough challenges with capsaicin and citric acid were performed in a large group of patients with chronic cough. The concentrations (...) of tussive agent causing two (C2) and five (C5) coughs were calculated. Measurements of capsaicin cough reflex sensitivity (median [interquartile range]) were significantly lower for female patients compared with male patients (C2: 1.9 [0.5 to 5.5] versus 5.3 [2.2 to 11.5] micro M, p = 0.0026; C5: 8.6 [2.2 to 34.0] versus 51.2 [7.2 to > 100] micro M, p = 0.0007). Similarly for citric acid challenge, values were significantly lower for female compared with male patients (C2: 53.5 [17.3 to 145.4] versus

2002 American Journal of Respiratory and Critical Care Medicine

22877. A Comparison of the Cough Profile of Fosinopril and Enalapril in Hypertensive Patients with a History of ACE Inhibitor-Associated Cough. (Abstract)

A Comparison of the Cough Profile of Fosinopril and Enalapril in Hypertensive Patients with a History of ACE Inhibitor-Associated Cough. OBJECTIVE: Cough frequency and severity with fosinopril and enalapril were assessed in hypertensive patients with previous angiotensin-converting enzyme inhibitor (ACEI)-associated cough. DESIGN: Prospective, multicenter, randomized, 8-week double-blind treatment. PATIENTS: One hundred seventy-nine patients (mild-to-moderate hypertension, nonsmokers, mean age (...) 58 years; 55% females; 72% Caucasian, 6% black, 19% Hispanic) were studied. Patients with other cough etiologies, significant co-morbidity, or confounding medications were excluded. INTERVENTIONS: Patients were randomized to fosinopril 10 mg (n = 85) or enalapril 5 mg (n = 94) once daily. Dosage could be doubled for blood pressure control after 4 weeks. Outcome measurements: The primary end point was all-cough frequency based on patient daily diary ratings; a cumulative cough frequency score

1995 American journal of therapeutics Controlled trial quality: uncertain

22878. Candesartan Cilexetil is not Associated with Cough in Patients with Enalapril-induced Cough. (Abstract)

Candesartan Cilexetil is not Associated with Cough in Patients with Enalapril-induced Cough. Treatment with angiotensin-converting enzyme (ACE) inhibitors is frequently associated with persistent dry cough. This side effect is thought to be due to the non-specific action of ACE inhibitors, which, in addition to suppressing the renin-angiotensin system (RAS), leads to the accumulation of kinins, encephalins and other biologically active peptides. Candesartan cilexetil is a new, long-acting (...) angiotensin II type 1 (AT 1 ) receptor blocker, which offers a more specific means of suppressing the RAS than can be achieved with ACE inhibitors. In this study, we compared the incidence and severity of cough during treatment with candesartan cilexetil, enalapril and placebo in patients with hypertension and enalapril-induced cough. Men and women, aged 20-80 years, with a history of medically treated primary hypertension and ACE-inhibitor-related cough were enrolled. The presence of cough was confirmed

2000 Blood pressure Controlled trial quality: uncertain

22879. Longitudinal decline in pulmonary function in atopic cough and cough variant asthma. (Abstract)

Longitudinal decline in pulmonary function in atopic cough and cough variant asthma. Cough variant asthma and atopic cough are different clinical manifestations of eosinophilic airway inflammation presenting with isolated chronic non-productive cough. The aim of this study was to examine the longitudinal change in pulmonary function in cough variant asthma and atopic cough.Longitudinal change in FEV1 was prospectively examined in 20 patients with cough variant asthma, 14 patients with atopic (...) cough and 271 asymptomatic healthy subjects. All were lifetime non-smokers. Of the 20 cough variant asthma patients, 13 were taking long-term inhaled corticosteroid therapy (ICS) (beclomethasone dipropionate 615 +/- 58 micro g/day) and the other seven were not. Spirometry was taken at first visit, after cough was almost completely relieved on therapy, and at least once every year for 5 or more years afterwards.The slope of longitudinal change in FEV1 was not significantly different among cough

2003 Clinical and Experimental Allergy

22880. Effect of manually assisted cough and mechanical insufflation on cough flow of normal subjects, patients with chronic obstructive pulmonary disease (COPD), and patients with respiratory muscle weakness Full Text available with Trip Pro

Effect of manually assisted cough and mechanical insufflation on cough flow of normal subjects, patients with chronic obstructive pulmonary disease (COPD), and patients with respiratory muscle weakness It has been suggested that cough effectiveness can be improved by assisted techniques. The effects of manually assisted cough and mechanical insufflation on cough flow physiology are reported in this study.The physiological actions and patient self-assessment of manually assisted cough (...) and mechanical insufflation were investigated in 29 subjects (nine normal subjects, eight patients with chronic obstructive pulmonary disease (COPD), four subjects with respiratory muscle weakness (RMW) with scoliosis, and eight subjects with RMW without scoliosis).The peak cough expiratory flow rate and cough expiratory volume were not improved by manually assisted cough and mechanical insufflation alone or in combination in normal subjects. The median increase in peak cough expiratory flow in subjects

2001 Thorax

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