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Cough

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22641. Nocturnal cough in asthma. Full Text available with Trip Pro

Nocturnal cough in asthma. The timing of nocturnal cough and its association with change in ambient temperature was documented in 11 asthmatic children, median age 5.1 years, while they were receiving continuous prophylaxis. Studies were performed in their homes on three nights. A voice activated system with electronic time signal recorded coughing. Ambient temperature was recorded every five minutes throughout the night on a Grant Squirrel data logger. Ten children coughed on 27 nights (...) with a median of six bouts of coughing a night (range 0-272). The cough rate in the two hours after going to bed was significantly higher than the cough rate in the middle of the night (2-4 am or 4-6 am). Peak coughing times were 7-9 pm and 6-8 am. The room temperature was lowest between 5 and 7 am. There were no significant differences between cough rates during periods of rapid temperature change (more than 1 degree C an hour). The timing of nocturnal cough observed in this study differed from the known

1987 Archives of Disease in Childhood

22642. Rapid diagnosis of whooping cough using monoclonal antibody. Full Text available with Trip Pro

Rapid diagnosis of whooping cough using monoclonal antibody. A counterimmunoelectrophoresis (CIE) method for antigen detection using monoclonal antibody was assessed for its ability to aid in the rapid diagnosis of Bordetella pertussis in 59 patients. A positive diagnosis from a combination of results from tests of serum and urine was obtained in 51 (87%) of cases. For sera, CIE had a sensitivity of 85% and a specificity of 94%; for urine samples the sensitivity was 81% and a specificity of 100

1988 Journal of Clinical Pathology

22643. Chronic cough and gastroesophageal reflux. Full Text available with Trip Pro

Chronic cough and gastroesophageal reflux. We reviewed the charts of 20 patients with chronic cough of unknown cause who had been referred to a tertiary care respiratory centre from 1980 to 1984 to determine whether gastroesophageal reflux (GER) was a contributing factor. Fifteen of the patients complained of symptoms suggestive of GER: radiologic investigation of the upper gastrointestinal tract revealed hiatus hernia and GER in four, hiatus hernia alone in three, GER alone in two, decreased (...) and metoclopramide) relieved the chronic cough in 14 of the 20 patients. Of the remaining patients one was lost to follow-up and five had GER confirmed by means of esophagoscopy, esophageal motility testing and long-term intraesophageal pH monitoring; four of the five patients underwent fundoplication and were asymptomatic 3 months after surgery. Antireflux therapy should be considered in patients with chronic cough when other causes have been ruled out, even if there are no GER symptoms. If the treatment fails

1989 CMAJ: Canadian Medical Association Journal

22644. Unusual Complication of ACE Inhibitor-Induced Cough Full Text available with Trip Pro

Unusual Complication of ACE Inhibitor-Induced Cough A cough produced by the administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril, resulted in a case of rectus abdominis hematoma. The author discusses the incidence and pathophysiology of ACE inhibitor-induced cough.

1989 Canadian Family Physician

22645. Recombinant human enkephalinase (neutral endopeptidase) prevents cough induced by tachykinins in awake guinea pigs. Full Text available with Trip Pro

Recombinant human enkephalinase (neutral endopeptidase) prevents cough induced by tachykinins in awake guinea pigs. To determine whether recombinant enkephalinase (neutral endopeptidase, EC 3.4.24.11) prevents cough induced by exogenously applied and endogenously released neuropeptides, we measured cough responses to aerosolized solutions of substance P or of capsaicin for 2 min in random-source guinea pigs before or after exposing them to aerosolized recombinant human enkephalinase. Substance (...) P (10(-16) M) increased coughing compared with its vehicle. Enkephalinase (120 micrograms) inhibited cough induced by subsequent exposure to substance P compared with the response to substance P alone, but after further exposure to the enkephalinase inhibitor leucine-thiorphan (10(-5) M), substance P increased cough significantly. Similar results were obtained for capsaicin-induced cough. In pathogen-free guinea pigs, after they inhaled inactive recombinant enkephalinase (33 micrograms

1989 Journal of Clinical Investigation

22646. Morbidity in whooping cough and measles. Full Text available with Trip Pro

Morbidity in whooping cough and measles. Parents of 99 children who were admitted to hospital with whooping cough or measles, and of 50 children with whooping cough or measles who were nursed at home, were interviewed to determine the extent of morbidity and its effects on the family. Children admitted with whooping cough or measles spent a mean of 12.6 and 5.8 days in hospital, respectively. Time to full recovery was 13.7 and 2.1 weeks, respectively. Over a third of the children who were

1989 Archives of Disease in Childhood

22647. Chronic cough in a hospital population; its relationship to atopy and defects in host defence. Full Text available with Trip Pro

Chronic cough in a hospital population; its relationship to atopy and defects in host defence. The background and aetiology of chronic cough were investigated by comparing 60 children under 6 years with simple cough, 60 children with asthma, and 60 controls. Both cough and asthma were more common in boys and associated with a history of eczema, chest deformity, and skin reactivity to inhaled allergens, but these findings were more prevalent in asthma than cough. House dust mite sensitivity (...) was found in 34 (57%) children with cough, 45 (75%) with asthma, and six (10%) controls. Tests of immunological function showed some high concentrations of IgM in groups with both cough and asthma, but high IgE concentrations, eosinophilia, and lymphocytosis were significant only in asthma. IgG1 and IgG2 concentrations were raised in some children with cough or asthma, but the only low subclass concentrations were of IgG3 observed in the group with cough. Children with simple cough represented

1989 Archives of Disease in Childhood

22648. Cough receptor sensitivity in children with acute and non-acute asthma Full Text available with Trip Pro

Cough receptor sensitivity in children with acute and non-acute asthma Cough is a major symptom in some children with asthma. The relationship between cough and the severity of asthma is ill defined. A study was undertaken to test the hypotheses that, in children with asthma who cough as a major part of their asthma symptoms, cough receptor sensitivity (CRS) is heightened during an acute severe exacerbation of asthma but not in the non-acute phase and airway calibre or its change correlates (...) with CRS.Spirometric measurements and the capsaicin CRS test were performed on children admitted to hospital for an acute severe exacerbation of asthma. Nasal secretions were tested for viruses. The children were grouped into those who usually cough with asthma episodes and those who do not. The tests were repeated 7-10 days and 4-6 weeks later. The CRS outcome measure used was the concentration of capsaicin required to stimulate two (Cth) and five coughs (C5).The CRS of the group who coughed (n = 15

1997 Thorax

22649. Chronic cough. What's the diagnosis? Full Text available with Trip Pro

Chronic cough. What's the diagnosis? 9356752 1997 12 11 2018 11 13 0008-350X 43 1997 Oct Canadian family physician Medecin de famille canadien Can Fam Physician Chronic cough. What's the diagnosis? 1731-2 Evans M F MF Toronto Hospital. michael.evans@utoronto.ca Frank J J eng Journal Article Canada Can Fam Physician 0120300 0008-350X IM Adolescent Adult Aged Aged, 80 and over Chronic Disease Cough diagnosis Female Humans Linear Models Male Medical History Taking Middle Aged Prospective Studies

1997 Canadian Family Physician

22650. ABC of palliative care. Breathlessness, cough, and other respiratory problems. Full Text available with Trip Pro

ABC of palliative care. Breathlessness, cough, and other respiratory problems. 9361545 1997 11 25 2008 11 20 0959-8138 315 7113 1997 Oct 11 BMJ (Clinical research ed.) BMJ ABC of palliative care. Breathlessness, cough, and other respiratory problems. 931-4 Davis C L CL eng Journal Article Review England BMJ 8900488 0959-8138 AIM IM Cough therapy Dyspnea therapy Hemoptysis therapy Humans Palliative Care Respiration Disorders therapy 0 1997 11 15 1997 11 15 0 1 1997 11 15 0 0 ppublish 9361545

1997 BMJ : British Medical Journal

22651. Trend in occurrence of asthma among children and young adults. Labelling of cough alone as asthma may partially explain increase. Full Text available with Trip Pro

Trend in occurrence of asthma among children and young adults. Labelling of cough alone as asthma may partially explain increase. 9365311 1997 11 26 2008 11 20 0959-8138 315 7114 1997 Oct 18 BMJ (Clinical research ed.) BMJ Trend in occurrence of asthma among children and young adults. Labelling of cough alone as asthma may partially explain increase. 1015 Chang A B AB Newson T P TP eng Letter England BMJ 8900488 0959-8138 AIM IM Adult Asthma epidemiology Australia epidemiology Child Cough

1997 BMJ : British Medical Journal

22652. [Chronic persistent cough]. (Abstract)

[Chronic persistent cough]. 7892152 1995 04 20 2013 11 21 0934-8387 49 1 1995 Jan Pneumologie (Stuttgart, Germany) Pneumologie [Chronic persistent cough]. 2-13 Kardos P P Gemeinschaftspraxis und Pneumologische Abteilung, Maingau Krankenaus v. Roten Kreuz, Frankfurt/M. ger Case Reports Journal Article Meta-Analysis Chronisch persistierender Husten (CHP). Germany Pneumologie 8906641 0934-8387 65M2UDR9AG Etretinate IM Adult Chronic Disease Cough chemically induced etiology Diagnosis, Differential

1995 Pneumologie (Stuttgart, Germany)

22653. The association of chronic cough with the risk of myocardial infarction: the Framingham Heart Study. (Abstract)

The association of chronic cough with the risk of myocardial infarction: the Framingham Heart Study. A persistent inflammatory response accompanying chronic infections may contribute to the risk of coronary atherothrombosis. Recent studies have reported an association between chronic respiratory infections and an increased risk of coronary heart disease; however, these reports have not accounted for important confounders such as impaired lung function.We considered chronic cough as an indicator (...) of chronic lung infection or inflammation in the original Framingham Heart Study participants aged 47 to 89 years. Chronic cough was defined as a cough present for at least 3 months in the preceding year and was categorized as either nonproductive or productive. The association of chronic cough with myocardial infarction was examined for six consecutive examination cycles (1965 to 1979) among participants free of myocardial infarction at the baseline examination. In a secondary analysis, plasma

1999 The American journal of medicine

22654. Prolonged cough and lung cancer: the need for more general practice research to inform clinical decision-making. Full Text available with Trip Pro

Prolonged cough and lung cancer: the need for more general practice research to inform clinical decision-making. Despite its clinical relevance, an extensive literature search for papers reporting on the relationship between prolonged cough and lung cancer revealed only one paper from a specialized setting. No study originating from primary care could be identified.

1997 British Journal of General Practice

22655. Antitussive effect of dextromethorphan and dextromethorphan-salbutamol combination in healthy volunteers with artificially induced cough. (Abstract)

Antitussive effect of dextromethorphan and dextromethorphan-salbutamol combination in healthy volunteers with artificially induced cough. The antitussive effects of dextromethorphan (30 mg) + salbutamol (2 mg), dextromethorphan (30 mg) alone and placebo on artificial cough induced by citric acid were compared in 19 healthy non-smoking volunteers in a double-blind crossover study. The method using inhaled citric acid with increasing concentrations to establish the cough threshold level showed (...) an acceptable reproducibility and proved to be suitable for comparison of antitussive drugs. The cough threshold level was assessed before as well as 90 and 180 min after each medication. After placebo the cough threshold level showed no statistically significant rise. However, significant rises were shown following dextromethorphan (p less than 0.001) and the dextromethorphan-salbutamol combination (p less than 0.001). Between the treatments significant differences were shown in favour

1987 Respiration; international review of thoracic diseases

22656. Effect of bronchodilators on the cough response to inhaled citric acid in normal and asthmatic subjects. Full Text available with Trip Pro

Effect of bronchodilators on the cough response to inhaled citric acid in normal and asthmatic subjects. Coughing was induced in seven normal and eight asthmatic subjects by giving successive inhalations of citric acid aerosols of progressively higher concentration (range 0.5-32%). A baseline cough response was obtained on each of four experimental days, and there was no significant difference between days in this respect. Then the subjects received by inhalation either a bronchodilator (...) (salbutamol 5 mg or ipratropium 1 mg) or placebo, in a paired double blind crossover design. A second citric acid run followed and was used for paired drug-placebo comparisons. In the asthmatic subjects the cough response was diminished by both bronchodilators (p less than 0.05), and the cough threshold was significantly higher after ipratropium but not salbutamol. In normal subjects no significant effects were found. Airways calibre was assessed, by an oscillatory technique that measures the resistance

1985 Thorax

22657. Intravenous lidocaine as a suppressant of coughing during tracheal intubation. (Abstract)

Intravenous lidocaine as a suppressant of coughing during tracheal intubation. Effects of intravenously administered lidocaine on cough suppression during tracheal intubation under general anesthesia were evaluated in two studies. In study 1, 100 patients received either a placebo or 0.5, 1.0, 1.5, or 2.0 mg/kg lidocaine intravenously 1 min before tracheal intubation. All visible coughs were classified as coughing. The incidence of coughing decreased as the dose of lidocaine increased. A dose (...) of 1 mg/kg or more of intravenous lidocaine suppressed the cough reflex significantly (P less than 0.01). Coughing was suppressed completely by 2 mg/kg of intravenous lidocaine. In study 2, 108 patients received 2 mg/kg lidocaine intravenously or a placebo 1, 3, 5, 7, 10, or 15 min before intubation. The same criteria for determining whether a patient did or did not cough during tracheal intubation were used as in study 1. The incidence of coughing decreased significantly (P less than 0.01) when 2

1985 Anesthesia and analgesia

22658. Effect of inhaled procaterol on cough receptor sensitivity to capsaicin in patients with asthma or chronic bronchitis and in normal subjects. Full Text available with Trip Pro

Effect of inhaled procaterol on cough receptor sensitivity to capsaicin in patients with asthma or chronic bronchitis and in normal subjects. To evaluate the effect of inhaled beta 2 adrenergic agonists on the sensitivity of airway cough receptors, the effect of inhaled procaterol on cough induced by aerosolised capsaicin, a stimulant of C fibres, was studied in patients with asthma or chronic bronchitis and in normal subjects.Eleven patients with asthma and 10 with chronic bronchitis and 14 (...) normal subjects participated. Increasing concentrations of capsaicin solution were inhaled for 15 seconds by tidal breathing through the mouth at one minute intervals until five or more coughs were elicited, before and 30 minutes after inhalation of 20 micrograms procaterol or placebo (freon gas alone) through a metered dose inhaler. Cough threshold was defined as the lowest concentration of capsaicin that elicited five or more coughs. To evaluate the bronchodilator effect of procaterol

1993 Thorax

22659. Sodium cromoglycate and atropine block the fall in FEV1 but not the cough induced by hypotonic mist. Full Text available with Trip Pro

Sodium cromoglycate and atropine block the fall in FEV1 but not the cough induced by hypotonic mist. In a group of patients with mild asthma the inhalation of mist derived from ultrasonically nebulised distilled water caused an increase in cough and a fall in FEV1. Double blind administration for five minutes of sodium cromoglycate (from an original solution containing 30 mg/ml) or atropine (2 mg/ml) by inhalation from a Minineb nebuliser, 30 minutes before the mist challenge, caused (...) a significant reduction in the fall in FEV1 (p less than 0.05), but not in cough, by comparison with the protection afforded by placebo (saline). In a second study the fall in FEV1 caused by the inhalation of distilled water was not significantly different from that seen in response to hypotonic sodium chloride (1.7 g/l, 58 mmol/l), but both produced a significantly greater fall than did a similar mist containing sodium cromoglycate at an original concentration of 10 mg/ml (58 mmol/l). The results show

1984 Thorax

22660. Cough and wheezing from beclomethasone aerosol. (Abstract)

Cough and wheezing from beclomethasone aerosol. Cough and wheezing are frequent side effects of inhaling beclomethasone dipropionate aerosol (BA) in patients with asthma. Twenty percent of our outpatient asthmatic subjects are unable to take BA due to these side effects. Twelve patients with history of severe cough and wheezing after inhaling BA were tested. Three puffs of either BA or placebo (Plc) were administered from a metered dose inhaler (MDI) in a double-blind crossover design (...) . They coughed a mean of 31 times after BA and 19 times after Plc. Forced expiratory volume in one sec (FEV1) declined a mean of 22.6 percent after BA and 22.0 percent after Plc. Pretreatment with albuterol attenuated both the cough and the drop in FEV1. Follow-up study showed that regular pretreatment with bronchodilator enabled seven of 12 patients to tolerate BA therapy. The remaining five required a short course of increased dose oral steroid therapy. Cough and wheezing are frequent side effects of BA

1987 Chest

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