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Cough Expectorant

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1. Cough Expectorant

Cough Expectorant Cough Expectorant Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Cough Expectorant Cough Expectorant Aka: Cough (...) Expectorant , Protussive , Guaifenesin , Robitussin , Humibid , Liquibid , Guaifenex From Related Chapters II. Indications Infectious cough (may speed recovery) (clear airway mucus) (assists with sinus drainage) III. Guaifenesin Short acting agents (e.g. Robitussin) Ages 2 to 5 years old: 2.5 ml PO q4h Ages 6 to 12 years old: 5 ml PO q4h Adults: 10 ml PO q4h Long acting agents Mucinex (Over-the-counter) Humabid LA with new, unproven formulation Contains guiacolsulfonate (old expectorant) Discontinued

2018 FP Notebook

2. A 43-year-old man with cough, expectoration and recurrent wheezing (PubMed)

A 43-year-old man with cough, expectoration and recurrent wheezing 28149536 2019 02 26 2072-1439 8 12 2016 Dec Journal of thoracic disease J Thorac Dis A 43-year-old man with cough, expectoration and recurrent wheezing. 3468-3477 10.21037/jtd.2016.12.106 Wang Hongyu H State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China

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2016 Journal of thoracic disease

3. Cough (acute): antimicrobial prescribing

to resistant bacteria. See the evidence and committee discussion on bronchodilators, corticosteroids, mucolytics, no antibiotic, back-up antibiotics and choice of antibiotic. 1.2 Self-care 1.2.1 Be aware that some people may wish to try the following self-care treatments, which have limited evidence of some benefit for the relief of cough symptoms: honey (in people aged over 1 year) pelargonium (a herbal medicine; in people aged 12 and over) over-the-counter cough medicines containing the expectorant (...) ) that causes cough and mucus production lasting for up to 3 weeks. It is usually caused by a viral infection, but may be caused by a bacterial infection. (NICE clinical knowledge summary on chest infections – adult). Self-care treatments Self-care treatments available for acute cough include honey, herbal medicines and over-the- counter cough medicines (for example, expectorants and cough suppressants [also called antitussives]). Cough (acute): antimicrobial prescribing (NG120) © NICE 2019. All rights

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

4. Antitussive, expectorant, and anti-inflammatory effects of Adenophorae Radix powder in ICR mice. (PubMed)

orally to mice once daily for 11 days, at dose levels of 400, 200, and 100 mg/kg. Theobromine (TB), ambroxol (AM) and dexamethasone (DEXA) were used as standard drugs for antitussive effects, expectorant effects and anti-inflammatory effects, respectively. Evaluations of antitussive effects were based on changes in body weight, the number of cough responses and the histopathology of the lung and trachea. Expectorant effects were based on changes in the body weight, macroscopic observations of body (...) Antitussive, expectorant, and anti-inflammatory effects of Adenophorae Radix powder in ICR mice. Adenophora triphylla var. japonica is frequently used as an oriental medicinal plant in Korea, China, and Japan for its anti-inflammatory, antitussive, and hepatoprotective effects.In the present study, the antitussive, expectorant, and anti-inflammatory effects of AR powder were investigated using animal models to evaluate their potential to treat respiratory disorders.AR powder was administered

2019 Journal of Ethnopharmacology

5. Impact of Hypertonic Saline Solutions on Sputum Expectoration and Their Safety Profile in Patients with Bronchiectasis: A Randomized Crossover Trial. (PubMed)

(7% HS; 0.1% HA +7%HS; and 0.9% isotonic saline, IS) were compared in outpatients with bronchiectasis and chronic sputum expectoration. Participants inhaled each solution across four consecutive sessions. All sessions, except on session 3, also included 30 minutes of airway clearance technique. A 7-day washout period was applied. Sputum weight was collected during the sessions (primary outcome) as well as during a 24-hour follow-up. The Leicester Cough Questionnaire (LCQ) and lung function were (...) Impact of Hypertonic Saline Solutions on Sputum Expectoration and Their Safety Profile in Patients with Bronchiectasis: A Randomized Crossover Trial. The role of hyaluronic acid plus hypertonic saline (HA+HS) as a mucoactive treatment in patients with bronchiectasis is still unknown. This study evaluated whether HA+HS solution enhances similar sputum quantity with better safety profile than HS alone in patients with bronchiectasis.In this double-blind randomized crossover trial, three solutions

2018 Journal of aerosol medicine and pulmonary drug delivery

6. Expectoration of <i>Cryptosporidium</i> Parasites in Sputum of Human Immunodeficiency Virus-Positive and -Negative Adults. (PubMed)

respiratory Cryptosporidium infection and TB persisted after controlling for HIV (odds ratio = 3.2, 95% confidence interval: 0.9, 11.8; P = 0.080). This is the first study to document adult respiratory tract cryptosporidiosis in a referral population with presumed TB. These findings 1) confirm that Cryptosporidium respiratory infection occurs in HIV-negative and -positive adults; 2) suggest there is potential for Cryptosporidium to be disseminated or transmitted by coughing or expectoration; and 3 (...) Expectoration of Cryptosporidium Parasites in Sputum of Human Immunodeficiency Virus-Positive and -Negative Adults. Respiratory cryptosporidiosis is thought to be a rare, end-stage complication of HIV. Few studies have systematically examined the frequency of such infection in adults. Sputum specimens submitted for tuberculosis (TB) testing at Mulago Hospital, Uganda, were anonymously retested for Cryptosporidium using real-time polymerase chain reaction (PCR). Visual confirmation using

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2018 American Journal of Tropical Medicine & Hygiene

7. [Results of international multicentre non-interventional clinical study of the effectiveness and safety of ascoril expectorant for the treatment of cough in Kazakhstan and Uzbekistan]. (PubMed)

[Results of international multicentre non-interventional clinical study of the effectiveness and safety of ascoril expectorant for the treatment of cough in Kazakhstan and Uzbekistan]. This paper reports results of international multicentre non-interventional clinical study of the effectiveness and safety of ascoril expectorant for the treatment of cough in Kazakhstan and Uzbekistan. The study included 16312 patients examined in different cities during 2011-2012. It showed that ascoril (...) expectorant (Glenmark) at a standard dose is an effective agent for the treatment of cough in children above 3 years and adults aged up to 78 years with ARVI and acute bronchitis, exacerbation of these conditions or grade I-II chronic obstructire pulmonary disease. Most patients reported good therapeutic effect within 1 day after intake. Ascoril expectorant caused no adverse reactions and was well tolerated by the patients. 91% of the attending physicians describe the drug as highly effective.

2014 Klinicheskaia meditsina

8. Positive Expiratory Pressure via Mask Does Not Improve Ventilation Inhomogeneity More than Huffing and Coughing in Individuals with Stable Chronic Obstructive Pulmonary Disease and Chronic Sputum Expectoration. (PubMed)

Positive Expiratory Pressure via Mask Does Not Improve Ventilation Inhomogeneity More than Huffing and Coughing in Individuals with Stable Chronic Obstructive Pulmonary Disease and Chronic Sputum Expectoration. Positive expiratory pressure (PEP) has been used to promote airway clearance in individuals with chronic obstructive pulmonary disease (COPD) for many years; however, its mechanism of action and benefits are unclear. Previous authors have suggested that PEP improves collateral (...) ventilation via changes in lung volumes.It was the aim of this study to determine whether PEP improves ventilation inhomogeneity more than controlled huffing and coughing in individuals with stable COPD.Twelve participants with COPD (mean forced expiratory volume in 1 s 45% predicted) and chronic sputum expectoration performed PEP therapy (10-20 cm H2O) or controlled huffing and coughing in random order on alternate study days with a 48-hour washout. Measures of acinar and conductive airway ventilation (S

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2014 Respiration; international review of thoracic diseases

9. A new method for enhanced expectoration of sputum by vibratory stimulation of the cervical trachea. (PubMed)

and this study aimed to compare it with the Acapella (a current oscillation device) method.Patients with chronic productive cough and difficulty with expectoration were recruited for the study. The tracheal vibration and Acapella methods were applied for 4 weeks each, according to a crossover design with an intervening 4-week washout period. To perform the tracheal vibration method, an electronic artificial larynx (Yourtone®) was applied to the cervical trachea for up to 5minutes. Patient preference (...) A new method for enhanced expectoration of sputum by vibratory stimulation of the cervical trachea. Expectoration of sputum can be difficult for patients with respiratory conditions such as chronic obstructive pulmonary disease, chronic bronchitis, or bronchiectasis because of the effects of decreased pulmonary function, respiratory muscle fatigue, altered sputum properties, and impaired ciliary function. We developed a new method for the vibratory stimulation of the cervical trachea

2017 Respiratory investigation

10. Over-the-counter (OTC) medications for acute cough in children and adults in community settings. (PubMed)

) involving 4835 people (3799 adults and 1036 children). All studies were placebo-controlled RCTs. However, assessment of the risk of bias of the included studies was limited by poor reporting, particularly for the earlier studies.In the adult studies, six trials compared antitussives with placebo and had variable results. Three trials compared the expectorant guaifenesin with placebo; one indicated significant benefit, whereas the other two did not. One trial found that a mucolytic reduced cough (...) /bronchodilator combinations (one study) were no more effective than placebo. No studies using expectorants met our inclusion criteria. The results of one trial favoured active treatment with mucolytics over placebo. One trial tested two paediatric cough syrups and both preparations showed a 'satisfactory response' in 46% and 56% of children compared to 21% of children in the placebo group. One new trial indicated that three types of honey were more effective than placebo over a three-day period.Twenty-one

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2014 Cochrane

11. A favorable clinical effect of an expectorant in allergic bronchopulmonary mycosis caused by Schizophyllum commune (PubMed)

A favorable clinical effect of an expectorant in allergic bronchopulmonary mycosis caused by Schizophyllum commune An 80-year-old Japanese woman with wet cough and dyspnea was diagnosed with pneumonia at a clinic. Antibiotics did not improve her symptoms; therefore, she was referred to our hospital one month after symptom onset. Chest radiograph findings revealed complete collapse of the left lung. Bronchoscopy showed white mucus plug in the left main bronchus, which could not be removed. She

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2016 Respiratory Medicine Case Reports

12. Cough

supportive care. Offer written information and verbal explanation. Consider referral to physiotherapy services if difficulty in expectorating retained secretions. Agree a self management plan which could include: cough diary smoking cessation advice. improved ventilation such as opening a window, putting on a fan coping strategies, such as: positioning and posture relaxation controlled breathing technique and effective coughing techniques, eg huffing. Seek specialist advice for the small number (...) Consider antisecretory, eg hyoscine to achieve acceptable moisture levels. Titrate carefully. Consider suction or cough assist machine. Precipitated by supra pharyngeal secretions Postnasal drip Sinusitis/allergies Nasal steroids Nasal decongestant spray, antihistamine, nasal steroids Cough Table 2. Version 1 May 2014 Medication In addition to the advice described in Table 2, consider treatment to aid expectoration: mucolytics - to reduce sputum viscosity, eg carbocisteine. Stop if no benefit after a 4

2015 Scottish Palliative Care Guidelines

13. Open Airway Surgery in a Paraplegic: The Importance of an Adequate Cough. (PubMed)

-anastomosis. Her postoperative course was complicated by mucus plugging and severe atelectasis, necessitating reintubation. After extubation, the patient reported difficulty expectorating secretions ever since her SCI, requiring manual abdominal pressure from her family members to assist her when she needed to cough.This first report of cricotracheal resection in a patient with paraplegia following SCI highlights the importance of an adequate cough and demonstrates the unique respiratory management (...) Open Airway Surgery in a Paraplegic: The Importance of an Adequate Cough. To describe a case of open airway surgery with postoperative respiratory complications in a paraplegic woman and to review the unique respiratory physiology seen in patients with a history of cervical or thoracic spinal cord injury (SCI).Case report and literature review.We describe the case of a 25-year-old paraplegic who developed tracheal stenosis after tracheotomy, eventually requiring tracheal resection and re

2019 Rhinology and Laryngology

14. Palliative care - cough

be considered. Managing symptomatic cough in palliative care can be done by a stepwise approach: Simple measures, such as humidified room air, or simple linctus. A weak opioid cough suppressant, such as codeine linctus. A strong opioid cough suppressant, such as morphine. Measures to encourage expectoration in people with moist cough and an effective cough mechanism, such as nebulized saline solution or a mucolytic. Have I got the right topic? Have I got the right topic? From age 16 years onwards. This CKS (...) nodes) causes abductor paralysis of the vocal cords. Hard, metallic-sounding 'brassy' cough — tracheal compression from intrathoracic lesions (may be associated with wheeze or stridor). Loose cough — secretions moving in the major airways (these may or may not be expectorated). Coughing with food or after a meal — aspiration from oesophageal or pharyngeal disease. Associated symptoms: Nasal discharge — cough may be caused by post-nasal drip. Sputum: Purulent sputum — infection. Frothy sputum — left

2017 NICE Clinical Knowledge Summaries

15. Systematic review: There is no good evidence for the effectiveness of commonly used over-the-counter medicine to alleviate acute cough

effects have been described. 1 Keeping the evidence up-to-date is very important. Methods The authors searched CENTRAL, MEDLINE, EMBASE, CINAHL, LILACS, Web of Science and the UK Department of Health National Research Register for randomised controlled trials comparing oral OTC cough medications to placebo in adults and children. Six types of cough medicines were reviewed and included: antitussives, expectorants, mucolytics, antihistamine decongestant combinations, antihistamines and other (...) Systematic review: There is no good evidence for the effectiveness of commonly used over-the-counter medicine to alleviate acute cough There is no good evidence for the effectiveness of commonly used over-the-counter medicine to alleviate acute cough | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log

2015 Evidence-Based Medicine (Requires free registration)

16. Cough Expectorant

Cough Expectorant Cough Expectorant Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Cough Expectorant Cough Expectorant Aka: Cough (...) Expectorant , Protussive , Guaifenesin , Robitussin , Humibid , Liquibid , Guaifenex From Related Chapters II. Indications Infectious cough (may speed recovery) (clear airway mucus) (assists with sinus drainage) III. Guaifenesin Short acting agents (e.g. Robitussin) Ages 2 to 5 years old: 2.5 ml PO q4h Ages 6 to 12 years old: 5 ml PO q4h Adults: 10 ml PO q4h Long acting agents Mucinex (Over-the-counter) Humabid LA with new, unproven formulation Contains guiacolsulfonate (old expectorant) Discontinued

2015 FP Notebook

17. Over-the-counter (OTC) medications for acute cough in children and adults in ambulatory settings. (PubMed)

variable results. Two trials compared the expectorant guaifenesin with placebo; one indicated significant benefit whereas the other did not. One trial found that a mucolytic reduced cough frequency and symptom scores. Two studies examined antihistamine-decongestant combinations and found conflicting results. Four studies compared other combinations of drugs with placebo and indicated some benefit in reducing cough symptoms. Three trials found antihistamines were no more effective than placebo (...) in relieving cough symptoms.In the children studies antitussives (two studies), antihistamines (two studies), antihistamine decongestants (two studies) and antitussive/bronchodilator combinations (one study) were no more effective than placebo. No studies using expectorants met our inclusion criteria. The results of one trial favoured active treatment with mucolytics over placebo. One trial tested two paediatric cough syrups and both preparations showed a 'satisfactory response' in 46% and 56% of children

2012 Cochrane

18. A Study of the Effect of 20 mg Ambroxol Hydrochloride on Acute Cough.

by Hull and East Yorkshire Hospitals NHS Trust: acute Additional relevant MeSH terms: Layout table for MeSH terms Cough Respiration Disorders Respiratory Tract Diseases Signs and Symptoms, Respiratory Signs and Symptoms Ambroxol Expectorants Respiratory System Agents (...) A Study of the Effect of 20 mg Ambroxol Hydrochloride on Acute Cough. A Study of the Effect of 20 mg Ambroxol Hydrochloride on Acute Cough. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study

2018 Clinical Trials

19. Study to Evaluate the Safety and Tolerability of Mucinexâ„¢(Guaifenesin) 600 mg Extended-Release Bi-Layer Tablets in the Treatment of Otherwise Healthy Patients With Symptoms of Cough, Thickened Mucus and Chest Congestion

Study to Evaluate the Safety and Tolerability of Mucinexâ„¢(Guaifenesin) 600 mg Extended-Release Bi-Layer Tablets in the Treatment of Otherwise Healthy Patients With Symptoms of Cough, Thickened Mucus and Chest Congestion Study to Evaluate the Safety and Tolerability of Mucinex™(Guaifenesin) 600 mg Extended-Release Bi-Layer Tablets in the Treatment of Otherwise Healthy Patients With Symptoms of Cough, Thickened Mucus and Chest Congestion - Full Text View - ClinicalTrials.gov Hide glossary (...) Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study to Evaluate the Safety and Tolerability of Mucinex™(Guaifenesin) 600 mg Extended-Release Bi-Layer Tablets in the Treatment of Otherwise Healthy Patients With Symptoms of Cough, Thickened Mucus and Chest

2018 Clinical Trials

20. The effect of pholcodine with and without an antihistamine on cough and expectoration. (PubMed)

The effect of pholcodine with and without an antihistamine on cough and expectoration. 22340 1978 02 18 2013 11 21 0007-0971 71 4 1977 Oct British journal of diseases of the chest Br J Dis Chest The effect of pholcodine with and without an antihistamine on cough and expectoration. 245-52 Edwards G F GF Lewis H E HE Stafford D D eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial England Br J Dis Chest 7511123 0007-0971 0 Drug Combinations 0 Histamine H1 Antagonists (...) 0 Morphine Derivatives RWO67D87EU Ethylmorphine IM Adult Aged Bronchitis drug therapy Chronic Disease Clinical Trials as Topic Cough drug therapy Double-Blind Method Drug Combinations Ethylmorphine analogs & derivatives therapeutic use Female Histamine H1 Antagonists therapeutic use Humans Male Middle Aged Morphine Derivatives therapeutic use Sputum analysis Tape Recording Time Factors 1977 10 1 1977 10 1 0 1 1977 10 1 0 0 ppublish 22340

1978 British Journal of Diseases of the Chest

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