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Cough Expectorant

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1. Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease. (Abstract)

expectoration of sputum by reducing its viscosity, thus making it easier to cough it up. Improved expectoration of sputum may lead to a reduction in exacerbations of COPD.Primary objective• To determine whether treatment with mucolytics reduces exacerbations and/or days of disability in patients with chronic bronchitis or COPDSecondary objectives• To assess whether mucolytics lead to improvement in lung function or quality of life• To determine frequency of adverse effects associated with use of mucolytics (...) Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease. Individuals with chronic bronchitis or chronic obstructive pulmonary disease (COPD) may suffer recurrent exacerbations with an increase in volume or purulence of sputum, or both. Personal and healthcare costs associated with exacerbations indicate that therapies that reduce the occurrence of exacerbations are likely to be useful. Mucolytics are oral medicines that are believed to increase

2019 Cochrane

2. Diseases of the respiratory system: cough suppressants, expectorants, and mucolytic agents. Full Text available with Trip Pro

Diseases of the respiratory system: cough suppressants, expectorants, and mucolytic agents. 25115 1978 06 28 2018 11 13 0007-1447 1 6121 1978 May 06 British medical journal Br Med J Diseases of the respiratory system: cough suppressants, expectorants, and mucolytic agents. 1202-3 Hughes D T DT eng Journal Article England Br Med J 0372673 0007-1447 0 Antitussive Agents 0 Drug Combinations 0 Expectorants 0 Histamine H1 Antagonists 7355X3ROTS Dextromethorphan 8V32U4AOQU Noscapine Q830PW7520 (...) Codeine AIM IM Antitussive Agents therapeutic use Codeine therapeutic use Cough drug therapy physiopathology Dextromethorphan therapeutic use Drug Combinations Drug Therapy, Combination Expectorants therapeutic use Histamine H1 Antagonists therapeutic use Humans Noscapine therapeutic use 1978 5 6 1978 5 6 0 1 1978 5 6 0 0 ppublish 25115 PMC1604265 J Pharmacol Exp Ther. 1975 Sep;194(3):499-505 1159627 Br J Dis Chest. 1977 Oct;71(4):245-52 22340 Arch Intern Med. 1977 Sep;137(9):1186-91 901087

1978 British medical journal

3. Cough Expectorant

Expectorant , Protussive , Guaifenesin , Robitussin , Humibid , Liquibid , Guaifenex From Related Chapters II. Indications Infectious cough (may speed recovery) (clear airway mucus) (assists with sinus drainage) III. Guaifenesin Short acting agents (e.g. Robitussin) Ages 2 to 5 years old: 2.5 ml PO q4h Ages 6 to 12 years old: 5 ml PO q4h Adults: 10 ml PO q4h Long acting agents Mucinex (Over-the-counter) Humabid LA with new, unproven formulation Contains guiacolsulfonate (old expectorant) Discontinued (...) agents Prior Humibid LA, Liquibid, Guaifenex LA Effect The only effective expectorant medication per FDA Paradoxically also reduces cough in URI Due to altered cough receptor sensitivity in URI IV. Other Expectorant Preparations (use with caution) Nebulized Used to induce for exam and culture ( ) Beta adrenergic agonist ( risk) Dose (age >12): 2.5 to 5 mg PO q6 hours while awake ( ) sparing Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search

2018 FP Notebook

4. Antitussive, expectorant, and anti-inflammatory effects of Adenophorae Radix powder in ICR mice. (Abstract)

orally to mice once daily for 11 days, at dose levels of 400, 200, and 100 mg/kg. Theobromine (TB), ambroxol (AM) and dexamethasone (DEXA) were used as standard drugs for antitussive effects, expectorant effects and anti-inflammatory effects, respectively. Evaluations of antitussive effects were based on changes in body weight, the number of cough responses and the histopathology of the lung and trachea. Expectorant effects were based on changes in the body weight, macroscopic observations of body (...) activities as compared to DEXA (1 mg/kg).The results obtained in this study suggest that AR powder exerts dose-dependent, favorable antitussive, expectorant, and anti-inflammatory activities achieved through modulation of the activity of mast cells and respiratory mucous production. Therefore, AR powder may serve as a therapeutic agent in various respiratory disorders, especially those that occur as a result of environmental toxicants.Copyright © 2019. Published by Elsevier B.V.

2019 Journal of Ethnopharmacology

5. Impact of Hypertonic Saline Solutions on Sputum Expectoration and Their Safety Profile in Patients with Bronchiectasis: A Randomized Crossover Trial. Full Text available with Trip Pro

(7% HS; 0.1% HA +7%HS; and 0.9% isotonic saline, IS) were compared in outpatients with bronchiectasis and chronic sputum expectoration. Participants inhaled each solution across four consecutive sessions. All sessions, except on session 3, also included 30 minutes of airway clearance technique. A 7-day washout period was applied. Sputum weight was collected during the sessions (primary outcome) as well as during a 24-hour follow-up. The Leicester Cough Questionnaire (LCQ) and lung function were (...) Impact of Hypertonic Saline Solutions on Sputum Expectoration and Their Safety Profile in Patients with Bronchiectasis: A Randomized Crossover Trial. The role of hyaluronic acid plus hypertonic saline (HA+HS) as a mucoactive treatment in patients with bronchiectasis is still unknown. This study evaluated whether HA+HS solution enhances similar sputum quantity with better safety profile than HS alone in patients with bronchiectasis.In this double-blind randomized crossover trial, three solutions

2018 Journal of aerosol medicine and pulmonary drug delivery Controlled trial quality: predicted high

6. Expectoration of <i>Cryptosporidium</i> Parasites in Sputum of Human Immunodeficiency Virus-Positive and -Negative Adults. Full Text available with Trip Pro

respiratory Cryptosporidium infection and TB persisted after controlling for HIV (odds ratio = 3.2, 95% confidence interval: 0.9, 11.8; P = 0.080). This is the first study to document adult respiratory tract cryptosporidiosis in a referral population with presumed TB. These findings 1) confirm that Cryptosporidium respiratory infection occurs in HIV-negative and -positive adults; 2) suggest there is potential for Cryptosporidium to be disseminated or transmitted by coughing or expectoration; and 3 (...) Expectoration of Cryptosporidium Parasites in Sputum of Human Immunodeficiency Virus-Positive and -Negative Adults. Respiratory cryptosporidiosis is thought to be a rare, end-stage complication of HIV. Few studies have systematically examined the frequency of such infection in adults. Sputum specimens submitted for tuberculosis (TB) testing at Mulago Hospital, Uganda, were anonymously retested for Cryptosporidium using real-time polymerase chain reaction (PCR). Visual confirmation using

2018 American Journal of Tropical Medicine & Hygiene

7. Efficacy of Percussive Ventilation Therapy (MetaNeb ®) Compared With Mucolytic Agents for Atelectasis in the Mechanically Ventilated Pediatric Patient

Efficacy of Percussive Ventilation Therapy (MetaNeb ®) Compared With Mucolytic Agents for Atelectasis in the Mechanically Ventilated Pediatric Patient Efficacy of Percussive Ventilation Therapy (MetaNeb ®) Compared With Mucolytic Agents for Atelectasis in the Mechanically Ventilated Pediatric Patient - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy of Percussive Ventilation Therapy (MetaNeb ®) Compared With Mucolytic Agents for Atelectasis in the Mechanically Ventilated Pediatric Patient The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our

2014 Clinical Trials

8. A new method for enhanced expectoration of sputum by vibratory stimulation of the cervical trachea. (Abstract)

and this study aimed to compare it with the Acapella (a current oscillation device) method.Patients with chronic productive cough and difficulty with expectoration were recruited for the study. The tracheal vibration and Acapella methods were applied for 4 weeks each, according to a crossover design with an intervening 4-week washout period. To perform the tracheal vibration method, an electronic artificial larynx (Yourtone®) was applied to the cervical trachea for up to 5minutes. Patient preference (...) A new method for enhanced expectoration of sputum by vibratory stimulation of the cervical trachea. Expectoration of sputum can be difficult for patients with respiratory conditions such as chronic obstructive pulmonary disease, chronic bronchitis, or bronchiectasis because of the effects of decreased pulmonary function, respiratory muscle fatigue, altered sputum properties, and impaired ciliary function. We developed a new method for the vibratory stimulation of the cervical trachea

2017 Respiratory investigation Controlled trial quality: uncertain

9. A 43-year-old man with cough, expectoration and recurrent wheezing Full Text available with Trip Pro

A 43-year-old man with cough, expectoration and recurrent wheezing 28149536 2019 02 26 2072-1439 8 12 2016 Dec Journal of thoracic disease J Thorac Dis A 43-year-old man with cough, expectoration and recurrent wheezing. 3468-3477 10.21037/jtd.2016.12.106 Wang Hongyu H State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China

2016 Journal of thoracic disease

10. [Results of international multicentre non-interventional clinical study of the effectiveness and safety of ascoril expectorant for the treatment of cough in Kazakhstan and Uzbekistan]. (Abstract)

expectorant (Glenmark) at a standard dose is an effective agent for the treatment of cough in children above 3 years and adults aged up to 78 years with ARVI and acute bronchitis, exacerbation of these conditions or grade I-II chronic obstructire pulmonary disease. Most patients reported good therapeutic effect within 1 day after intake. Ascoril expectorant caused no adverse reactions and was well tolerated by the patients. 91% of the attending physicians describe the drug as highly effective. (...) [Results of international multicentre non-interventional clinical study of the effectiveness and safety of ascoril expectorant for the treatment of cough in Kazakhstan and Uzbekistan]. This paper reports results of international multicentre non-interventional clinical study of the effectiveness and safety of ascoril expectorant for the treatment of cough in Kazakhstan and Uzbekistan. The study included 16312 patients examined in different cities during 2011-2012. It showed that ascoril

2014 Klinicheskaia meditsina Controlled trial quality: uncertain

11. Positive Expiratory Pressure via Mask Does Not Improve Ventilation Inhomogeneity More than Huffing and Coughing in Individuals with Stable Chronic Obstructive Pulmonary Disease and Chronic Sputum Expectoration. Full Text available with Trip Pro

Positive Expiratory Pressure via Mask Does Not Improve Ventilation Inhomogeneity More than Huffing and Coughing in Individuals with Stable Chronic Obstructive Pulmonary Disease and Chronic Sputum Expectoration. Positive expiratory pressure (PEP) has been used to promote airway clearance in individuals with chronic obstructive pulmonary disease (COPD) for many years; however, its mechanism of action and benefits are unclear. Previous authors have suggested that PEP improves collateral (...) ventilation via changes in lung volumes.It was the aim of this study to determine whether PEP improves ventilation inhomogeneity more than controlled huffing and coughing in individuals with stable COPD.Twelve participants with COPD (mean forced expiratory volume in 1 s 45% predicted) and chronic sputum expectoration performed PEP therapy (10-20 cm H2O) or controlled huffing and coughing in random order on alternate study days with a 48-hour washout. Measures of acinar and conductive airway ventilation (S

2014 Respiration; international review of thoracic diseases Controlled trial quality: uncertain

12. Cough (acute): antimicrobial prescribing

to resistant bacteria. See the evidence and committee discussion on bronchodilators, corticosteroids, mucolytics, no antibiotic, back-up antibiotics and choice of antibiotic. 1.2 Self-care 1.2.1 Be aware that some people may wish to try the following self-care treatments, which have limited evidence of some benefit for the relief of cough symptoms: honey (in people aged over 1 year) pelargonium (a herbal medicine; in people aged 12 and over) over-the-counter cough medicines containing the expectorant (...) . Mucolytics Mucolytics (oral acetylcysteine and oral carbocisteine) were significantly better than placebo for reducing cough at 6 to 7 days in children with acute upper and lower respiratory tract infection (4.1% versus 13.8%; very low quality evidence), but not at the end of treatment (28 days; very low quality evidence). There were no significant differences between mucolytics and placebo for the outcomes of productive cough and expectoration at end of treatment (at 7 days), pulmonary function at day 3

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

13. A favorable clinical effect of an expectorant in allergic bronchopulmonary mycosis caused by Schizophyllum commune Full Text available with Trip Pro

A favorable clinical effect of an expectorant in allergic bronchopulmonary mycosis caused by Schizophyllum commune An 80-year-old Japanese woman with wet cough and dyspnea was diagnosed with pneumonia at a clinic. Antibiotics did not improve her symptoms; therefore, she was referred to our hospital one month after symptom onset. Chest radiograph findings revealed complete collapse of the left lung. Bronchoscopy showed white mucus plug in the left main bronchus, which could not be removed. She

2016 Respiratory Medicine Case Reports

14. Mucolytic Effectiveness of Tacholiquine ® in Chronic Bronchitis

, Obstructive Bronchial Diseases Respiratory Tract Infections Expectorants Respiratory System Agents (...) Mucolytic Effectiveness of Tacholiquine ® in Chronic Bronchitis Mucolytic Effectiveness of Tacholiquine ® in Chronic Bronchitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Mucolytic Effectiveness

2015 Clinical Trials

15. <i>In Vivo</i> Evaluation of the Antiasthmatic, Antitussive, and Expectorant Activities and Chemical Components of Three <i>Elaeagnus</i> Leaves. Full Text available with Trip Pro

In Vivo Evaluation of the Antiasthmatic, Antitussive, and Expectorant Activities and Chemical Components of Three Elaeagnus Leaves. The leaf of Elaeagnus lanceolata and Elaeagnus henryi as well as Elaeagnus pungens has been documented as an effective herb for the treatment of asthma and chronic bronchitis in traditional clinical medicine. This study was aimed at evaluating the antiasthmatic, antitussive, and expectorant activities of the water extracts from the three plants (...) in vivo and analyzing their chemical components by HPLC-DAD. At the medium and high doses, the water extracts of three Elaeagnus leaves significantly prolonged the preconvulsive time (P < 0.01) in guinea pigs, lengthened the latent period of cough (P < 0.01) and decreased the cough frequency caused by aqueous ammonia in mice (P < 0.01), and enhanced tracheal phenol red output in mice (P < 0.01). There were no significant differences in the pharmacological actions between the three Elaeagnus leaves

2015 Evidence-based Complementary and Alternative Medicine (eCAM)

16. The Challenge of Obtaining Qualitative Bacterial Cultures in Non-expectorating Cystic Fibrosis Patients

sputum and bronchoalveolar lavage (BAL) are the gold standard. However, BAL is an invasive method, not designated to repeat monthly. Therefore, the diagnosis of lower respiratory tract infections can be challenging in the non-expectorating CF patient. Other methods, such as induced sputum (IS), cough swabs and nasal swabs, have been developed to obtain bacterial cultures in these patients. Studies have investigated the reliability of these different sampling methods, however, with controversial (...) conclusions. Condition or disease Intervention/treatment Cystic Fibrosis Procedure: Nasal swab Procedure: Cough swab Procedure: Spontaneous expectorated sputum Procedure: Induced sputum Procedure: Bronchoalveolar lavage Other: Questionnaire Detailed Description: I. Protocol design: The current protocol is designed to compare: Group 1: nasal swab, cough swab and spontaneous expectorated sputum in expectorating CF patients Group 2: nasal swab, cough swab and induced sputum in non-expectorating CF patients

2015 Clinical Trials

17. Expectorant, antitussive, anti-inflammatory activities and compositional analysis of aster tataricus. (Abstract)

Expectorant, antitussive, anti-inflammatory activities and compositional analysis of aster tataricus. The root of Aster tataricus L. f., recorded in all versions of Chinese Pharmacopoeia, is a traditional Chinese medicine with the function of dispelling phlegm and relieving cough for more than 2000 years. This study was designed to evaluate the expectorant, antitussive, and anti-inflammatory activities of the root of A. tataricus and to explore the chemical substances responsible (...) for these activities.The 70% ethanol extract of the root of A. tataricus (RA-70) was divided into three fractions, Fr-0, Fr-50 and Fr-95. They were all orally administrated to the mice to investigate their potential expectorant activities by a tracheal phenol red secretion method. The most effective fraction, together with shionone, was evaluated the expectorant, antitussive and anti-inflammatory activities by the mouse models of phenol red secretion, ammonia-induced cough, and xylene-induced ear swelling. Furthermore

2015 Journal of Ethnopharmacology

18. Expectorant and Antitussive Effect of Hedera helix and Rhizoma coptidis Extracts Mixture Full Text available with Trip Pro

effect on phenol red secretion (25.25±3.14) and cough inhibition (61.25±5.36) than the individual use of each extracts [phenol red secretion; HH 13.39±4.22 (p=0.000), RC 20.78±2.50 (p=0.010), cough inhibition; HH 9.89±4.14 (p=0.010), RC 30.25±7.69 (p=0.000)]. A 3:1 ratio mixture of HH to RC demonstrated an optimal expectorant effect (p<0.001), and this mixture showed expectorant and antitussive effects in a dose-dependent manner.This study provides evidence for antitussive and expectorant effect (...) Expectorant and Antitussive Effect of Hedera helix and Rhizoma coptidis Extracts Mixture This study aims to investigate the additive effect of the Hedera helix (HH) and Rhizoma coptidis (RC) extracts mixture on antitussive and expectorant activities in animals.The expectorant assay was performed with phenol red secretion in mice trachea. Mice or guinea pigs were randomly divided into groups of 8 each, including negative and positive control groups. After gastric administration of the test

2015 Yonsei medical journal

19. Cough Expectorant

Expectorant , Protussive , Guaifenesin , Robitussin , Humibid , Liquibid , Guaifenex From Related Chapters II. Indications Infectious cough (may speed recovery) (clear airway mucus) (assists with sinus drainage) III. Guaifenesin Short acting agents (e.g. Robitussin) Ages 2 to 5 years old: 2.5 ml PO q4h Ages 6 to 12 years old: 5 ml PO q4h Adults: 10 ml PO q4h Long acting agents Mucinex (Over-the-counter) Humabid LA with new, unproven formulation Contains guiacolsulfonate (old expectorant) Discontinued (...) agents Prior Humibid LA, Liquibid, Guaifenex LA Effect The only effective expectorant medication per FDA Paradoxically also reduces cough in URI Due to altered cough receptor sensitivity in URI IV. Other Expectorant Preparations (use with caution) Nebulized Used to induce for exam and culture ( ) Beta adrenergic agonist ( risk) Dose (age >12): 2.5 to 5 mg PO q6 hours while awake ( ) sparing Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search

2015 FP Notebook

20. Managing Chronic Cough as a Symptom in Children and Management Algorithms: CHEST Guideline and Expert Panel Report

. For children with chronic cough (>4-weeks) after acute viral bronchiolitis, we suggest 182 that the cough be managed according to the CHEST pediatric chronic cough guidelines, 183 asthma medications not be used for the cough unless other evidence of asthma is present, 184 and inhaled osmotic agents not be used. 8 (Ungraded Consensus–based Statement) 185 26. For children with chronic cough, we suggest that the presence or absence of night time 186 cough or cough with a barking or honking character should (...) who can expectorate, productive cough is the preferred term. The 599 presence of chronic wet/productive cough leads to a divergent pathway within the algorithm 32 600 (Figure 3). The evidence using antibiotics for a chronic wet cough when there no other symptoms 601 27 and signs (e.g. dysphagia or digital clubbing) suggesting PBB, is now strong. 65 While many 602 questions remain, PBB as a clinical entity is also now widely accepted. 65,105,106,107 603 15. For children aged = 14-years with chronic

2020 American College of Chest Physicians

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