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Corticotropin Stimulation Test

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101. Cortisol Test

. For more information on reference ranges, please read . What is being tested? Cortisol is a steroid , produced by the , which is essential for survival. Cortisol is a steroid hormone that breaks down fat and protein and stimulates glucose production in the liver. It helps the body react to physical and emotional stress, helps to regulate blood pressure, to control inflammation, and can affect cardiovascular function. The production and secretion of cortisol is stimulated by produced by the – a tiny (...) and a short stature. Increased cortisol production may be seen as a result of: ACTH-producing , in the pituitary gland ( ) and/or in other parts of the body that stimulate the adrenal glands to produce cortisol (Cushings syndrome) Adrenal gland tumour or due to excessive growth of adrenal tissues ( ) How is the sample collected for testing? Typically, a blood sample will be taken by a syringe with needle from a vein in the arm, but sometimes urine or saliva may be tested. Blood should ideally be collected

2012 Lab Tests Online UK

102. Effects of Progesterone on IV Nicotine-Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Effect

induced changes on anterior pituitary (ACTH, LH, and Prolactin) and adrenal hormones (DHEA and cortisol). We also plan to study norepinephrine (NE) and epinephrine (E), because nicotine stimulates rapid release of NE and E in preclinical and clinical studies. The study will examine the acute effects of progesterone on the effects of IV nicotine on the HPG axis. Progesterone's influence on the acute effects of nicotine on the gonadal steroid hormones (estradiol, testosterone, progesterone) are unknown (...) Effects of Progesterone on IV Nicotine-Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Effect Effects of Progesterone on IV Nicotine-Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Effect - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2012 Clinical Trials

103. The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine responses in human blood and is sorted into placental exosomes. (Abstract)

The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine responses in human blood and is sorted into placental exosomes. To examine whether syncytin-1 has immune regulatory functions and is carried by human placental exosomes. Further, to examine whether corticotropin-releasing hormone (CRH) can induce the production of syncytin-1.Human placental exosomes were isolated from placental explant, primary trophoblast and BeWo cell cultures. The presence of exosomes (...) was confirmed by transmission electron microscopy and western blotting. Exosomal protein was probed with 3 separate antibodies targeting syncytin-1. Syncytin-1 immunosuppression was tested, using either a syncytin-1 recombinant ectodomain protein or a synthetic peptide with the human syncytin-1 immunosuppressive domain sequence, in an in vitro human blood culture system immune challenged with LPS or PHA. The inhibition of cytokine production by syncytin-1 was determined by ELISA of TNF-α, IFN-γ and CXCL10

2012 Placenta

104. Hormonal Responses to Synthetic Luteinizing Hormone and Follicle Stimulating Hormone-Releasing Hormone in Man Full Text available with Trip Pro

Hormonal Responses to Synthetic Luteinizing Hormone and Follicle Stimulating Hormone-Releasing Hormone in Man The effects of the gonadotrophin-releasing hormone, synthetic decapeptide luteinizing hormone/follicle stimulating hormone-releasing hormone (LH/FSH-RH), have been studied in 18 normal men and five women in the follicular phase of their menstrual cycle. Rapid and dose-dependent (25 to 100 mug) increases in serum immunoreactive LH were seen, which reached a peak 20 to 30 minutes after (...) a rapid intravenous injection. Similar but much smaller increases in serum immunoreactive FSH were seen. These conclusions have been validated by using two different immunoassay systems for each hormone. The LH/FSH-RH therefore causes both LH and FSH release in man as in animals but does not affect growth hormone, thyrotrophin, or ACTH. The gonadotrophin responses were the same in the women as in the men but were insufficient in the men to cause statistically significant changes in the serum levels

1972 British medical journal

105. The Diagnostic Accuracy of the Glucagon Stimulation Test for Evaluation of Adult Growth Hormone Deficiency and the Hypothalamic-Pituitary-Adrenal Axis

The Diagnostic Accuracy of the Glucagon Stimulation Test for Evaluation of Adult Growth Hormone Deficiency and the Hypothalamic-Pituitary-Adrenal Axis The Glucagon Stimulation Test for Evaluation of Adult Growth Hormone Deficiency and Adrenocorticotropic Axis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have (...) reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Glucagon Stimulation Test for Evaluation of Adult Growth Hormone Deficiency and Adrenocorticotropic Axis (GST) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01282164 Recruitment Status

2011 Clinical Trials

106. Value of 25 mcg Cortrosyn Stimulation Test

Go to Brief Summary: The diagnosis of secondary AI is vital to prevent catastrophic events in patients. An optimal test should have a very low margin of error with high sensitivity and specificity, be easy and safe to administer, and have distinct cut off values. Both 1 ug and 250 ug doses have their limitations. Based on our experience over the past six years, we hypothesize that 25 ug ACTH stimulation test may eliminate some of the shortcomings of the LDST (1 ug) and SDST (250 ug (...) ). This is supported by our preliminary data and the study by Oelkers et al, which looked at ACTH levels following various doses of cortrosyn injections. Therefore we propose a head to head comparison of 25 ug, 250 ug and 1 ug dose using ITT as gold standard. Condition or disease Intervention/treatment Phase Adrenal Insufficiency Procedure: 1 ug ACTH stimulation test Procedure: 250 ug ACTH stimulation test Procedure: 25 ug Cortrosyn stimulation test Procedure: Insulin tolerance test Not Applicable Study Design Go

2011 Clinical Trials

107. Significance of Adrenocorticotropin Stimulation Test in the Diagnosis of an Aldosterone-Producing Adenoma. Full Text available with Trip Pro

Significance of Adrenocorticotropin Stimulation Test in the Diagnosis of an Aldosterone-Producing Adenoma. Adrenal venous sampling is the "gold standard" test in the diagnosis of an aldosterone-producing adenoma (APA) among patients with primary aldosteronism (PA) but is available only in specialized medical centers. Meanwhile, an APA is reported to be generally more sensitive to ACTH than idiopathic hyperaldosteronism.The aim was to evaluate the diagnostic accuracy of the ACTH stimulation test (...) in the diagnosis of an APA among those with suspicion of PA.Fifty-nine patients admitted to Kyoto University Hospital on suspicion of PA were included in the study.ACTH stimulation tests with 1-mg dexamethasone suppression were performed.Plasma aldosterone concentrations (PAC) were examined every 30 min after ACTH stimulation. Receiver-operated characteristics curve analysis was used to evaluate the diagnostic accuracy.PAC after ACTH stimulations were significantly higher in patients with an APA than

2011 Journal of Clinical Endocrinology and Metabolism

108. Low prevalence of hypopituitarism after Subarachnoid Haemorrhage using confirmatory testing and with BMI-specific growth hormone cut-off levels. Full Text available with Trip Pro

prospectively a cohort of SAH survivors for development of hypopituitarism post-SAH using rigorous endocrine testing and compare GH response to glucagon stimulation with a cohort of healthy controls of a similar BMI.Sixty-four patients were investigated for evidence of hypopituitarism 3 months post-SAH with 50 patients tested again at 12 months. Glucagon stimulation testing (GST), with confirmation of deficiencies by GHRH/arginine testing for GH deficiency (GHD) and short synacthen testing for ACTH (...) deficiency, was used. Basal testing of other hormonal axes was undertaken.Mean age of patients was 53±11.7 years and mean BMI was 27.5±5.7 kg/m(2). After confirmatory testing, the prevalence of hypopituitarism was 12% (GHD 10%, asymptomatic hypocortisolaemia 2%). There was no association between hypopituitarism and post-SAH vasospasm, presence of cerebral infarction, Fisher grade, or clinical grading at presentation. There was a significant correlation between BMI and peak GH to glucagon stimulation

2012 European Journal of Endocrinology

109. Combined test of anterior pituitary function in children. Full Text available with Trip Pro

Combined test of anterior pituitary function in children. A combined test of anterior pituitary function was used on 21 normal children. It shows that a comprehensive evaluation can be made of growth hormone, thyroid stimulating hormone, adrenocorticotrophic hormone, and gonadotrophin reserve. Simultaneous assessment of those peripheral glands associated with the anterior pituitary is possible by the measurement of thyroid hormones, cortisol, and gonadal steroids. The procedure can be completed

1978 Archives of Disease in Childhood

110. Corticotropin Releasing Hormone (CRH) Responsiveness in Children With Functional Dyspepsia

dyspepsia react to CRH, we will do a CRH stimulation test. A CRH stimulation test is routinely done in endocrine patients. It is not routinely done for patients with functional dyspepsia or for patients who do not have functional dyspepsia. Part of the CRH stimulation test is giving a synthetic type of corticotropin, Acthrel® (brand name for Corticorelin), as injection. Acthrel® has been approved by the Food and Drug Administration (FDA) for use. The purpose of this research study is to see (...) Corticotropin Releasing Hormone (CRH) Responsiveness in Children With Functional Dyspepsia Corticotropin Releasing Hormone (CRH) Responsiveness in Children With Functional Dyspepsia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2011 Clinical Trials

111. Prevention of West Syndrome With Low-dose Adrenocorticotropin Hormone (ACTH)

Resource links provided by the National Library of Medicine related topics: related topics: available for: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: ACTH treatment Infants with a Type 3 EEG (pre-hypsarhythmia) will be treated with ACTH for 2 weeks. Drug: adrenocorticotropin hormone ACTH 16 units intramuscular injection once daily for 2 weeks Other Name: H.P. Acthar® Gel (repository corticotropin injection) Outcome Measures Go to Primary Outcome Measures : Evidence (...) Hormones Adrenocorticotropic Hormone Melanocyte-Stimulating Hormones beta-Endorphin Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action

2011 Clinical Trials

112. ACTH-Dependent Regulation of MicroRNA As Endogenous Modulators of Glucocorticoid Receptor Expression in the Adrenal Gland. Full Text available with Trip Pro

stimulation, four of the predefined miR (miR-96, miR-101a, miR-142-3p, and miR-433) were found to putatively target the glucocorticoid receptor [nuclear receptor subfamily 3, group C, member 1 (Nr3c1)]. Nr3c1 expression levels were elevated 10 min after ACTH stimulation but decreased after 60 min in comparison with baseline conditions. Modified Nr3c1-3'-untranslated region constructs were further tested by in vitro luciferase assays. Thereby, we could confirm that miR96, miR101a, miR142-3p, and miR433 (...) homeostasis upon stressful stimuli, here, we determined the miR expression pattern in mouse adrenal glands under baseline conditions, as well as 10, 30, and 60 min upon ACTH stimulation, using miR microarray. Changes in miR expression levels detected by array analysis were confirmed by real-time PCR and further analyzed by bioinformatic tools to identify miR that putatively target genes involved in adrenal function. After selecting miR, with a significant change in their expression level upon ACTH

2011 Endocrinology

113. Clinical 15 Months Study Comparing Monthly Pulse ACTH (Acthar Gel) Therapy With Monthly Methylprednisolone (MP, Solumedrol) for Multiple Sclerosis (MS) Patients Who Are on Regular Beta-interferons (Avonex, Betaseron or Rebif)

of Southern California Information provided by (Responsible Party): Regina Berkovich, University of Southern California Study Details Study Description Go to Brief Summary: We hypothesize that corticotropin or adrenocorticotrophic hormone (ACTH), administered as Acthar Gel® (MANUFACTURER NAME) is effective in the control of clinical disease activity as a pulse therapy for relapsing-remitting MS when added to standard treatment with beta-interferon. We wish to determine whether ACTH, when administered (...) relevant MeSH terms: Layout table for MeSH terms Sclerosis Multiple Sclerosis Pathologic Processes Demyelinating Autoimmune Diseases, CNS Autoimmune Diseases of the Nervous System Nervous System Diseases Demyelinating Diseases Autoimmune Diseases Immune System Diseases Methylprednisolone Methylprednisolone Acetate Methylprednisolone Hemisuccinate Prednisolone Prednisolone acetate Prednisolone hemisuccinate Prednisolone phosphate Adrenocorticotropic Hormone Melanocyte-Stimulating Hormones beta-Endorphin

2010 Clinical Trials

114. Technical details influence the diagnostic accuracy of the 1 microg ACTH stimulation test. Full Text available with Trip Pro

Technical details influence the diagnostic accuracy of the 1 microg ACTH stimulation test. To examine the factors causing inadequate cortisol responses to the 1 microg ACTH stimulation test.Random test assignment (by age and gender) at 0800 or 1600 h.We recruited 20 healthy adults to each of the three age groups (<40 years, 40-55 years, and >55 years; half females in each group). ACTH stimulation tests were performed in an outpatient clinic at the NIH Clinical Research Center. Plasma cortisol (...) was measured just before, and 30 and 60 min after the administration of 1 microg ACTH (1-24). The ACTH concentration in diluted and administered solutions was measured.Twenty-five volunteers (19 at 1600 h) had a subnormal cortisol response (peak cortisol 10.4-17.5 microg/dl), using a criterion <18 microg/dl (497 nmol/l), for a specificity of 58% (confidence interval (CI) 45-71%). Afternoon testing had a significant impact on failure rates (odds ratio 6.98, CI 2.17-22.43), while gender and age did

2010 European journal of endocrinology / European Federation of Endocrine Societies Controlled trial quality: uncertain

115. Approach to the Genitourinary Patient - Testing

-hydrated, sodium- and potassium-replete patients. Plasma renin, aldosterone, cortisol , and ACTH should be measured in evaluation of all of the following: Adrenal insufficiency Hyperaldosteronism The plasma aldosterone/renin ratio calculated from measurements obtained with the patient in an upright posture is the best screening test for hyperaldosteronism, provided that plasma renin activity is < 0.5 ng/mL/h and aldosterone is > 12 to 15 ng/dL. Evaluating Kidney Function Kidney function is evaluated (...) Approach to the Genitourinary Patient - Testing Evaluation of the Renal Patient - Genitourinary Disorders - MSD Manual Professional Edition Brought to you by The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases / / / / IN THIS TOPIC OTHER TOPICS IN THIS CHAPTER

2013 Merck Manual (19th Edition)

116. Precocious puberty

stimulation test MRI brain CT brain 17-hydroxyprogesterone urinary steroid profile ACTH stimulation test CT or MRI adrenals ultrasound adrenals bone scan/skeletal survey other pituitary hormone investigations genetic testing thyroid function tests overnight gonadotrophin profile Treatment algorithm ACUTE Contributors Authors Paediatric Endocrinologist London UK Disclosures AM is an author of several articles cited within this topic. Professor of Paediatric Endocrinology University College London London UK (...) , or aromatase inhibitors and anti-androgens. Treatment should be stopped once an acceptable age of puberty is reached. Definition Puberty is an interval characterised by the acquisition of the secondary sexual characteristics, accelerated linear growth, increase in the secretion of sex hormones, maturation of gonads (testes in boys; ovaries in girls), and the potential for reproduction. It is typically complete within 2 to 5 years. Precocious puberty should be considered when secondary sexual

2019 BMJ Best Practice

117. Hyponatraemia

water excretion fractional excretion of sodium thyroid-stimulating hormone serum cortisol level and/or adrenocorticotrophic hormone test serum lipids and serum protein electrophoresis CT brain, chest, abdomen/pelvis other tests targeted at evaluating the underlying cause Treatment algorithm ACUTE ONGOING Contributors Authors Associate Director Nephrology MedStar Washington Hospital Center Washington DC Disclosures JHV declares that she has no competing interests. Peer reviewers Director Department (...) 25;170(3):G1-47. http://www.eje-online.org/content/170/3/G1.long http://www.ncbi.nlm.nih.gov/pubmed/24569125?tool=bestpractice.com Hyponatraemia is generally caused by an increase in renal water reabsorption due to release of vasopressin (arginine vasopressin also known as antidiuretic hormone) along with water intake, and can occur in situations of volume depletion, volume overload, or normal volume. (It should be noted that loss of sodium is minor compared with gains in water in most types

2019 BMJ Best Practice

118. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children Full Text available with Trip Pro

that these guidelines should constitute a general scheme of “best practice,” but that translation to treatment algorithms or bundles and standards of care will need to account for variation in the availability of local healthcare resources. The panel acknowledges as well the need for future research to test the adaptation of interventions to locally available resources. Funding and Sponsorship All funding for the development of these guidelines was provided by SCCM and ESICM. In addition, sponsoring organizations (...) provide a valuable indirect marker of tissue hypoperfusion ( ). Although increased lactate levels are not specific, they provide a quantifiable surrogate for tissue hypoxia and can be rapidly obtained by point-of-care tests available in many settings. In adults, blood lactate greater than 2 mmol/L is now included within the operational definition of septic shock as an indication of cellular/metabolic dysfunction, and measurement of lactate is included in the Hour-1 Sepsis Bundle, with recommendations

2020 Society of Critical Care Medicine

119. European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity

, developmental delay PTH ? calcium ? phosphate ? ACTH, adrenocorticotropic hormone; FSH, follicle-stimulating hormone; FT4, free thyroxine; GH, growth hormone; IGF, insulin-like growth factor; LH, luteinizing hormone; MC4R, melanocortin receptor 4; ODST, overnight dexamethasone suppression test; PCSK, proprotein convertase subtilisin/kexin; PTH, parathyroid hormone; TSH, thyroid-stimulating hormone. Downloaded from Bioscientifica.com at 02/19/2020 06:38:23AM via free accessEuropean Journal of Endocrinology (...) , adrenocorticotropic hormone; CBG, corticosteroid-binding globulin; CRH, corticotropin-releasing hormone; FFA, free fatty acids; FSH, follicle-stimulating hormone; FT4, free thyroxine; GH-BP, growth hormone-binding protein; GHRH, growth hormone- releasing hormone; GLP, glucagon-like peptide; GnRH, gonadotropin-releasing hormone; HPA, hypothalamic–pituitary–adrenal axis; IGF, insulin-like growth factor; LH, luteinizing hormone; PCOS, polycystic ovary syndrome; PTH, parathyroid hormone; SHBG, sex hormone-binding

2020 European Society of Endocrinology

120. Unsupported Price Increase Assessment

$13,685 19.1% Copaxone® $1,711 7.8% Prezista®/ Prezcobix® $1,119 16.4% Revlimid® $6,469 25.8% Novolog®/Mix $1,700 13.3% Acthar® $1,110 14.3% Enbrel® $4,807 19.0% Lucentis® $1,695 -64.3% Levemir® $1,091 9.2% Rituxan® $4,384 17.0% Cosentyx® $1,674 15.9% Sprycel® $1,091 14.3% Opdivo® $4,239 4.6% Botox® $1,639 3.8% Cimzia® $1,055 17.8% Keytruda® $4,149 5.4% Mavyret™ $1,599 -- Simponi®/Aria $1,051 17.2% Eylea® $4,077 0.0% Latuda® $1,574 20.8% Rebif® $1,032 15.4% Neulasta® $3,866 14.4% Vyvanse® $1,573 (...) ($39) Revlimid # Victoza $207 Activase/ TNKase ($43) Sensipar # Chantix $206 Sprycel ($70) Avastin # Odefsey $203 Triumeq ($79) Pomalyst # Descovy $198 Simponi/Aria ($106) Acthar # Xolair $183 Xeljanz ($123) Prevnar Family # Afinitor/Disperz $177 Trulicity ($125) Jakafi # Aubagio $162 Jardiance ($204) Fluzone # Prezista/ Prezcobix $133 Cosentyx ($208) Orencia # Gilenya $114 Eliquis ($222) Invega Sustenna/ Trinza # Humalog/Mix $107 Restasis ($267) *In millions. †Exact value provided by Genentech

2020 California Technology Assessment Forum

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