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Corticotropin Stimulation Test

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81. High-dosage short-term corticotrophin therapy in acute asthma Full Text available with Trip Pro

High-dosage short-term corticotrophin therapy in acute asthma 4307610 1969 09 04 2018 11 13 0040-6376 24 4 1969 Jul Thorax Thorax High-dosage short-term corticotrophin therapy in acute asthma. 415-20 Glick I W IW Friedman M M eng Journal Article England Thorax 0417353 0040-6376 9002-60-2 Adrenocorticotropic Hormone WI4X0X7BPJ Hydrocortisone IM Adolescent Adrenal Glands drug effects Adrenocorticotropic Hormone administration & dosage Adult Aged Asthma drug therapy Female Humans Hydrocortisone (...) blood Injections, Intramuscular Male Middle Aged Respiratory Function Tests Respiratory System physiopathology Spirometry Stimulation, Chemical Time Factors 1969 7 1 1969 7 1 0 1 1969 7 1 0 0 ppublish 4307610 PMC472004 Br Med J. 1965 Feb 27;1(5434):562-7 14243060 Nature. 1965 Apr 10;206(980):158-60 4284051 Proc R Soc Med. 1968 Mar;61(3):291-3 4297157 Br Med J. 1954 Feb 27;1(4860):486-90 13126543 Perspect Biol Med. 1964;7:71-84 14215618 Thorax. 1965 Jan;20:93-8 14255493 Am J Med Sci. 1960 Aug;240:213

1969 Thorax

82. The Effects of Corticotrophin and Corticoids on Secretion from Denervated Gastric Pouches in Dogs Full Text available with Trip Pro

The Effects of Corticotrophin and Corticoids on Secretion from Denervated Gastric Pouches in Dogs The effects of corticotrophin and of cortisone, methyl prednisolone, and of aldosterone on the gastric secretion of dogs have been investigated. Juice was collected from dogs with denervated pouches under basal conditions and when stimulated with meat extract and with histamine. For each secretion the volume, viscosity, and pH were measured, and the concentrations of hydrochloric acid, pepsin (...) , sodium, potassium, and chloride estimated. In the pharmacological doses used all the substances produced similar effects. Volume and acidity of the secretion were increased and there was a decrease in the viscosity of the basal secretion. The concentration of pepsin and of sodium and potassium were decreased while the chloride concentration was unaffected. Cortisone (the only steroid tested in this respect) increased the maximal secretory response to histamine. Three to five days elapsed before any

1960 Gut

83. Acute-Onset Panhypopituitarism Nearly Missed by Initial Cosyntropin Testing Full Text available with Trip Pro

panhypopituitarism. MRI showed a new sellar metastasis. After 2 weeks, stimulated cortisol in cosyntropin testing reached only 219 nmol/l, confirming adrenal insufficiency.The time course showed that the adrenal glands took 2 weeks to atrophy after loss of pituitary ACTH secretion. Therefore, a misleading result of the cosyntropin test in the initial phase with low basal cortisol and allegedly normal response to exogenous ACTH may be seen. Cosyntropin testing in the critically ill should be interpreted (...) Acute-Onset Panhypopituitarism Nearly Missed by Initial Cosyntropin Testing Diagnosis of adrenal crisis and panhypopituitarism in patients with septic shock is difficult but crucial for outcome.A 66-year-old woman with metastasized breast cancer presented to the ED with respiratory insufficiency and septic shock after a 2-day history of the flu. After transfer to the ICU, corticosteroids were started in addition to antibiotics, as the patient was vasopressor-nonresponsive. Diabetes insipidus

2017 Case reports in critical care

84. ACTH in Progressive Forms of MS

provided by (Responsible Party): University of Minnesota - Clinical and Translational Science Institute Study Details Study Description Go to Brief Summary: This is a phase II, randomized, double-blind, placebo-controlled, multi-center study to evaluate the safety, tolerability, and efficacy of adrenocorticotropic hormone (ACTH, Acthar gel) administered as a pulsed regimen consisting of injections on three consecutive days per month in patients with progressive forms of Multiple Sclerosis (MS (...) for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 100 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: Treatment of Progressive Forms of Multiple Sclerosis With Pulsed ACTH (Acthar Gel) Study Start Date : October 2013 Estimated Primary Completion Date : March 2021 Estimated Study Completion Date : March 2022

2013 Clinical Trials

85. A cellular and molecular basis for the selective desmopressin-induced ACTH release in Cushing's disease patients: key role of AVPR1b receptor and potential therapeutic implications. Full Text available with Trip Pro

A cellular and molecular basis for the selective desmopressin-induced ACTH release in Cushing's disease patients: key role of AVPR1b receptor and potential therapeutic implications. Desmopressin is a synthetic agonist of vasopressin receptors (AVPRs). The desmopressin stimulation test is used in the diagnosis and postsurgery prognosis of Cushing disease (CD). However, the cellular and molecular mechanisms underlying the desmopressin-induced ACTH increase in patients with CD are poorly (...) understood.The objectives of this study were to determine, for the first time, whether desmopressin acts directly and exclusively on pituitary corticotropinoma cells to stimulate ACTH expression/release and to elucidate the cellular and molecular mechanisms involved in desmopressin-induced ACTH increase in CD.A total of 8 normal pituitaries (NPs), 23 corticotropinomas, 14 nonfunctioning pituitary adenomas, 17 somatotropinomas, and 3 prolactinomas were analyzed for AVPR expression by quantitative real-time RT

2013 Journal of Clinical Endocrinology and Metabolism

86. Anomalous responses to stimulation and suppression tests in Cushing's syndrome due to a calcified adrenal adenoma Full Text available with Trip Pro

Anomalous responses to stimulation and suppression tests in Cushing's syndrome due to a calcified adrenal adenoma 4377169 1975 11 08 2018 11 13 0032-5473 49 578 1973 Dec Postgraduate medical journal Postgrad Med J Anomalous responses to stimulation and suppression tests in Cushing's syndrome due to a calcified adrenal adenoma. 923-6 Epstein S S Goldin A R AR McLaren E H EH eng Journal Article England Postgrad Med J 0234135 0032-5473 7S5I7G3JQL Dexamethasone 9002-60-2 Adrenocorticotropic Hormone (...) IM Adenoma complications Adrenal Gland Neoplasms complications Adrenal Glands drug effects Adrenocorticotropic Hormone pharmacology Adult Calcinosis complications Cushing Syndrome etiology Dexamethasone pharmacology Female Humans 1973 12 1 1973 12 1 0 1 1973 12 1 0 0 ppublish 4377169 PMC2495454 Am J Med. 1969 Oct;47(4):619-24 4309844 J Endocrinol. 1965 Nov;33(3):515-24 5845673 Br J Radiol. 1972 Aug;45(536):621-3 5045980 Metabolism. 1958 Sep;7(5):608-23 13577415 Acta Endocrinol (Copenh). 1964 Jun

1973 Postgraduate medical journal

87. Appropriateness of Adrenocorticotropic Hormone Stimulation Test for Critically Ill Patients Full Text available with Trip Pro

Appropriateness of Adrenocorticotropic Hormone Stimulation Test for Critically Ill Patients In earlier work, it was shown that patients with septic shock who also have adrenal insufficiency experience a benefit in terms of lower mortality rates with hydrocortisone supplementation. As such, the adrenocorticotropic hormone (ACTH) stimulation test has been used frequently to identify these patients. However, recent evidence has suggested that the identification and treatment of adrenal (...) insufficiency in patients with septic shock does not reduce mortality. These results call into question the utility of the ACTH stimulation test in this patient population.To determine the indications for ordering the ACTH stimulation test for critically ill patients at a tertiary care hospital and to classify the indications as either appropriate (e.g., primary adrenal insufficiency or medication-induced suppression of the hypothalamus-pituitary-adrenal axis) or inappropriate (e.g., patients with septic

2010 The Canadian journal of hospital pharmacy

88. ACTH stimulation test Full Text available with Trip Pro

ACTH stimulation test ACTH stimulation test - Wikipedia ACTH stimulation test From Wikipedia, the free encyclopedia ACTH stimulation test , The ACTH test (also called the cosyntropin , tetracosactide , or Synacthen test ) is a usually ordered and interpreted by to assess the functioning of the stress response by measuring the adrenal response to (ACTH; corticotropin) or another such as (cosyntropin, tetracosactrin; Synacthen) or (Synchrodyn). ACTH is a hormone produced in the that stimulates (...) showed that Synacthen test results can be used to predict future recovery of HPA axis function in patients with reversible causes of Adrenal Insufficiency. Other hormones and chemicals that will rise in the ACTH stimulation test [ ] - precursor to cortisol and aldosterone - a pituitary hormone that stimulates sex hormone production DHEA and DHEA-S - androgen hormones produced in the adrenal glands Simple diagnostic chart [ ] Source of pathology CRH ACTH DHEA DHEA-S Cortisol Aldosterone Renin Na K

2012 Wikipedia

89. Corticosteroid secretion: responses to 1-24 corticotropin, metyrapone and dexamethasone. Full Text available with Trip Pro

Adrenocorticotropic Hormone WI4X0X7BPJ Hydrocortisone ZS9KD92H6V Metyrapone IM Adrenal Cortex Hormones administration & dosage metabolism Adrenal Glands drug effects physiology Adrenocorticotropic Hormone metabolism pharmacology Circadian Rhythm Dexamethasone pharmacology Humans Hydrocortisone blood Hypothalamus physiology Metyrapone pharmacology Pituitary Gland physiology Pituitary-Adrenal Function Tests Stimulation, Chemical 1972 1 1 1972 1 1 0 1 1972 1 1 0 0 ppublish 4339147 PMC2441267 Arch Intern Med. 1966 (...) Corticosteroid secretion: responses to 1-24 corticotropin, metyrapone and dexamethasone. 4339147 1972 09 05 2018 11 30 0065-7778 83 1972 Transactions of the American Clinical and Climatological Association Trans. Am. Clin. Climatol. Assoc. Corticosteroid secretion: responses to alpha1-24 corticotropin, metyrapone and dexamethasone. 45-56 Frawley T F TF eng Journal Article United States Trans Am Clin Climatol Assoc 7507559 0065-7778 0 Adrenal Cortex Hormones 7S5I7G3JQL Dexamethasone 9002-60-2

1972 Transactions Of The American Clinical And Climatological Association

90. Alterations in response of rat white adipocytes to insulin, noradrenaline, corticotropin and glucagon after adrenalectomy. Correction of these changes by adenosine deaminase. Full Text available with Trip Pro

. Adipocytes from adrenalectomized rats had decreased lipolytic responses to all concentrations of noradrenaline and glucagon tested and a decreased lipolytic response to low but not high concentrations of corticotropin. There was no difference in lipolytic response to theophylline after adrenalectomy. Adenosine deaminase corrected the differences in response to noradrenaline and glucagon resulting from adrenalectomy. 3. In the presence of adenosine deaminase rates of lipolysis, after stimulation by high (...) Alterations in response of rat white adipocytes to insulin, noradrenaline, corticotropin and glucagon after adrenalectomy. Correction of these changes by adenosine deaminase. 1. Adipocytes isolated from rats 6--9 days after adrenalectomy had significantly increased sensitivity to insulin action against noradrenaline-stimulated lipolysis. In the presence of adenosine deaminase there was no significant difference in insulin sensitivity between cells from adrenalectomized and sham-operated rats. 2

1978 Biochemical Journal

91. A reappraisal of the effects of ACTH on the response of the central nervous system to injury. Full Text available with Trip Pro

A reappraisal of the effects of ACTH on the response of the central nervous system to injury. ACTH possesses powerful immuno-suppressive properties and also retards healing by inhibiting fibroblast proliferation and the deposition of collagen. In the present work this hormone was used to test both the 'barrier' and 'immune' hypotheses relating to the failure of CNS regeneration after injury, dosages being administered which had been found to stimulate maximal adrenal production

1979 Journal of anatomy

92. Transcranial Magnetic Stimulation (TMS) in Obesity

Stimulation (dTMS) was proposed to reduce appetite and food craving in obese subjects, leading eventually to a weight reduction. dTMS was already tested successfully in other forms of addiction (smoking, alcohol, cocaine) and the usefulness of dTMS in the treatment of food addiction, and therefore in obesity, was hypothesized. End-points of this research will be: 1) effect on food craving; 2) acute and chronic effects on blood level of hormones acting on the appetite regulation; 3) chronic effects on body (...) and chronic changes induced by repetitive dTMS on the neuro-endocrine pathway involved in the hunger/satiety balance, the following parameter will be considered: ACTH (pg/mL). ACTH will be evaluated acutely (before and immediately after the first and the last rTMS sessions) and chronically (at baseline, at end of treatment and at the 3 follow-up visits). Acute and chronic changes in Thyroid-Stimulating Hormone (TSH) levels induced by repetitive dTMS from baseline at 5 weeks [ Time Frame: Baseline and end

2016 Clinical Trials

93. Cosyntropin-stimulated serum free cortisol in healthy, adrenally-insufficient, and mildly cirrhotic populations. Full Text available with Trip Pro

Cosyntropin-stimulated serum free cortisol in healthy, adrenally-insufficient, and mildly cirrhotic populations. Serum free cortisol (SFF) responses to cosyntropin simulation test (CST) may more accurately assess adrenal function than total cortisol (TF).The objective of the study was to evaluate the diagnostic utility of SFF responses during a 250-μg CST.We recruited healthy volunteers (HV; n = 27), patients with primary and secondary adrenal insufficiency (n = 19 and n = 24, respectively (...) ), and subjects with Child-Pugh class A cirrhosis (CH; n = 15). Each received 250 μg cosyntropin with measurement of ACTH and corticosteroid binding globulin (CBG) at time 0 and TF and SFF at 0, 30, and 60 minutes. Salivary cortisol was measured at all time points in CH subjects.Peak SFF and TF were significantly higher in HVs vs both AI groups (P < .05). Peak SFF and TF (6.8 μg/dL vs 2.2 μg/dL; [188 nmol/L vs 62 nmol/L]; P < .01) were significantly higher in the secondary adrenal insufficiency vs primary

2015 Journal of Clinical Endocrinology and Metabolism

94. Copeptin under glucagon stimulation Full Text available with Trip Pro

Copeptin under glucagon stimulation Stimulation of growth hormone (GH) and adrenocorticotropic hormone (ACTH) secretion by glucagon is a standard procedure to assess pituitary dysfunction but the pathomechanism of glucagon action remains unclear. As arginine vasopressin (AVP) may act on the release of both, GH and ACTH, we tested here the role of AVP in GST by measuring a stable precursor fragment, copeptin, which is stoichiometrically secreted with AVP in a 1:1 ratio. ACTH, cortisol, GH (...) stimulated over time and the maximal increment correlated with ACTH, while correlations between copeptin and GH were weaker. Interestingly, copeptin as well as GH secretion was significantly attenuated when comparing subjects within the highest to those in the lowest BMI quartile (p < 0.05). Copeptin is significantly released following glucagon stimulation. As this release is BMI-dependent, the time-dependent relation between copeptin and GH may be obscured, whereas the close relation to ACTH suggests

2015 Endocrine

95. Adrenal Function Testing Following Hormone Therapy for Infantile Spasms: Case Series and Review of Literature Full Text available with Trip Pro

Adrenal Function Testing Following Hormone Therapy for Infantile Spasms: Case Series and Review of Literature Prednisolone and adrenocorticotropic hormone (ACTH) are "hormone" therapies for infantile spasms. There is limited data on the occurrence of decreased adrenal reserve or signs of clinical adrenal insufficiency after hormone therapy. This is a retrospective medical record review of patients referred to our Infantile Spasms Program. Our standardized infantile spasms management guideline (...) began in September 2012 and initially included a post-hormone laboratory assessment of adrenal function. Medical records were assessed for hormone treatments, adrenal function testing, and signs of adrenal insufficiency. Forty-two patients who received one or both hormone therapies met inclusion criteria. A post-hormone laboratory assessment of adrenal function was done in 14 patients. Of these 14 patients, 2 had an abnormal laboratory assessment of adrenal function, both by adrenal stimulation

2015 Frontiers in neurology

96. NeSST2: The Development of a Noninvasive Short Synacthen Test

is injected to stimulate the adrenal glands and multiple blood samples are collected to assess the response in terms of cortisol production. It is invasive, time consuming and unpleasant for the child. Our project aims to produce a noninvasive alternative to the current SST, with Synacthen given nasally and using saliva to measure the subsequent production of cortisol. A noninvasive test will allow us to establish the first normal ranges for children and determine which children with asthma are at risk (...) NeSST2: The Development of a Noninvasive Short Synacthen Test NeSST2: The Development of a Noninvasive Short Synacthen Test - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. NeSST2: The Development

2015 Clinical Trials

97. Acupuncture Stimulation Attenuates Impaired Emotional-Like Behaviors and Activation of the Noradrenergic System during Protracted Abstinence following Chronic Morphine Exposure in Rats. Full Text available with Trip Pro

was injected once to extend despair-related withdrawal behaviors for 4 weeks. Acupuncture stimulation was performed once at the SP6 (Sanyinjiao) acupoint on rat's; hind leg for 5 min during protracted abstinence from morphine. The acupuncture stimulation significantly decreased despair-like behavior deficits in the forced swimming test and low sociability in the open-field test as well as increased open-arm exploration in the elevated plus maze test in the last week of 4-week withdrawal period. Also (...) the acupuncture stimulation significantly suppressed the increase in the hypothalamic corticotropin-releasing factor (CRF) expression, the decrease in the tyrosine hydroxylase expression in the locus coeruleus, and the decrease in the hippocampal brain-derived neurotrophic factor mRNA expression, induced by repeated injection of morphine. Taken together, these findings demonstrate that the acupuncture stimulation of SP6 significantly reduces withdrawal-induced behaviors, induced by repeated administration

2014 Evidence-based Complementary and Alternative Medicine (eCAM)

98. Follicle-Stimulating Hormone Abnormalities (Overview)

etiology is related to primary hypogonadism or a gonadotroph adenoma. Therefore, the following lab tests are indicated: LH and testosterone levels In patients with gonadotroph adenomas, other pituitary hormone levels must also be assessed because macroadenomas may induce hypopituitarism; serum TSH and free thyroxine (T4), morning cortisol and adrenocorticotropic hormone (ACTH), prolactin, and, occasionally, dynamic testing for growth hormone (GH) may be necessary Peripheral leukocyte karyotype (...) luteinizing hormone (LH), another gonadotropin. FSH and LH are composed of alpha and beta subunits. The specific beta subunit confers the unique biologic activity. FSH and LH bind to receptors in the testis and ovary and regulate gonadal function by promoting sex steroid production and gametogenesis. [ ] In men, LH stimulates testosterone production from the interstitial cells of the testes (Leydig cells). FSH stimulates testicular growth and enhances the production of an androgen-binding protein

2014 eMedicine.com

99. Follicle-Stimulating Hormone Abnormalities (Diagnosis)

etiology is related to primary hypogonadism or a gonadotroph adenoma. Therefore, the following lab tests are indicated: LH and testosterone levels In patients with gonadotroph adenomas, other pituitary hormone levels must also be assessed because macroadenomas may induce hypopituitarism; serum TSH and free thyroxine (T4), morning cortisol and adrenocorticotropic hormone (ACTH), prolactin, and, occasionally, dynamic testing for growth hormone (GH) may be necessary Peripheral leukocyte karyotype (...) luteinizing hormone (LH), another gonadotropin. FSH and LH are composed of alpha and beta subunits. The specific beta subunit confers the unique biologic activity. FSH and LH bind to receptors in the testis and ovary and regulate gonadal function by promoting sex steroid production and gametogenesis. [ ] In men, LH stimulates testosterone production from the interstitial cells of the testes (Leydig cells). FSH stimulates testicular growth and enhances the production of an androgen-binding protein

2014 eMedicine.com

100. Free and Total Plasma Cortisol Measured by Immunoassay and Mass Spectrometry Following ACTH1-24 Stimulation in the Assessment of Pituitary Patients. Full Text available with Trip Pro

total and free plasma cortisol by LCMS and total cortisol by immunoassay during an ACTH₁₋₂₄ stimulation test to define HPA status in pituitary patients.This was a case control study conducted in a clinical research facility.We studied 60 controls and 21 patients with pituitary disease in whom HPA sufficiency (n = 8) or deficiency (n = 13) had been previously defined.Participants underwent 1 μg ACTH(1-24) intravenous and 250 μg ACTH₁₋₂₄ intramuscular ACTH₁₋₂₄ stimulation tests.Concordance of ACTH (...) Free and Total Plasma Cortisol Measured by Immunoassay and Mass Spectrometry Following ACTH1-24 Stimulation in the Assessment of Pituitary Patients. Measurement of plasma cortisol by immunoassay after ACTH₁₋₂₄ stimulation is used to assess the hypothalamic-pituitary-adrenal (HPA) axis. Liquid chromatography-tandem mass spectrometry (LCMS) has greater analytical specificity than immunoassay and equilibrium dialysis allows measurement of free plasma cortisol.We investigated the use of measuring

2013 Journal of Clinical Endocrinology and Metabolism Controlled trial quality: uncertain

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