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Corticotropin Stimulation Test

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1. Salivary Cortisol and Cortisone After Low-Dose Corticotropin Stimulation in the Diagnosis of Adrenal Insufficiency (PubMed)

Salivary Cortisol and Cortisone After Low-Dose Corticotropin Stimulation in the Diagnosis of Adrenal Insufficiency Basal and poststimulation salivary cortisol and cortisone levels can be useful in the diagnosis of adrenal insufficiency. However, little is known about the optimal cutoffs and performance characteristics of these tests.To derive the cutoff values and study the performance characteristics of salivary cortisol and salivary cortisone in the diagnosis of adrenal (...) insufficiency.Prospective study in a regional hospital in Hong Kong from January 2014 to September 2015.Fifty-six Chinese healthy volunteers and 171 patients suspected of having adrenal insufficiency.All participants underwent low-dose short Synacthen test (LDSST) with intravenous injection of 1 μg of tetracosactide (Synacthen 1-24). Serum cortisol, salivary cortisol and cortisone levels were measured at baseline and 30 and 60 minutes afterward.Using the reference cutoff (mean - 2 standard deviations of post-LDSST peak

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2017 Journal of the Endocrine Society

2. Corticotropin Stimulation Test

Corticotropin Stimulation Test Corticotropin Stimulation Test Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Corticotropin (...) Stimulation Test Corticotropin Stimulation Test Aka: Corticotropin Stimulation Test , Cosyntropin Stimulation Test , ACTH Stimulation Test II. Indications evaluation 8am level decreased III. Technique Obtain Baseline Labs Plasma Adrenocorticotropic Hormone (ACTH) Level level Plasma aldosterone Plasma renin activity Administer cosyntropin (ACTH) Administer ACTH 250 mcg IV Repeat Obtain at 30 and 60 minutes after IV ACTH IV. Interpretation Low cortisol level (<18 mcg/dl) and high plasma ACTH (>50 pg/ml

2018 FP Notebook

3. Estradiol-dependent stimulation and suppression of gonadotropin-releasing hormone (GnRH) neuron firing activity by corticotropin-releasing hormone (CRH) in female mice. (PubMed)

Estradiol-dependent stimulation and suppression of gonadotropin-releasing hormone (GnRH) neuron firing activity by corticotropin-releasing hormone (CRH) in female mice. Gonadotropin-releasing hormone (GnRH) neurons are the final central regulators of reproduction, integrating various inputs that modulate fertility. Stress typically inhibits reproduction but can be stimulatory; stress effects can also be modulated by steroid milieu. Corticotropin-releasing hormone (CRH) released during (...) the stress response may suppress reproduction independent of downstream glucocorticoids. We hypothesized CRH suppresses fertility by decreasing GnRH neuron firing activity. To test this, mice were ovariectomized (OVX) and either implanted with an estradiol capsule (OVX+E) or not treated further to examine the influence of estradiol on GnRH neuron response to CRH. Targeted extracellular recordings were used to record firing activity from green fluorescent protein-identified GnRH neurons in brain slices

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2017 Endocrinology

4. Corticotropin-releasing factor stimulates colonic motility via muscarinic receptors in the rat (PubMed)

Corticotropin-releasing factor stimulates colonic motility via muscarinic receptors in the rat To measure exogenous corticotropin-releasing factor (CRF)-induced motility of the isolated rat colon and to demonstrate the effect of pharmacologic inhibition on CRF-induced motility.The isolated vascularly-perfused rat colon was used. Luminal pressure was monitored via microtip catheter pressure transducers in the proximal and distal colon. At first, exogenous CRF was administered in a stepwise (...) manner and the concentration of CRF yielding maximal colonic motility was selected. After recording basal colonic motility, hexamethonium, phentolamine, propranolol, atropine and tetrodotoxin were infused into the isolated colon. Initially, only the test drug was infused; then, CRF was added. The motility index was expressed as percentage change over basal level.Administration of 1.4, 14.4, 144 and 288 pmol/L CRF progressively increased colonic motility in the proximal and distal colon. Infusion

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2017 World Journal of Gastroenterology

5. Salivary alpha-amylase and noradrenaline responses to corticotropin-releasing hormone administration in humans. (PubMed)

parameters remains questionable. Therefore, we employed the corticotropin-releasing hormone (CRH) stimulation test to pharmacologically activate the sympathetic nervous system and to analyze plasma noradrenaline response together with sAA activity. Thirty-one healthy male volunteers (mean age of 25.2±3.1years) were randomized into two groups and received injections with either CRH (100μg, N=17) or placebo (0.9% NaCl, N=14). Blood samples were taken at baseline and 15, 30, 60, 120min after injection (...) Salivary alpha-amylase and noradrenaline responses to corticotropin-releasing hormone administration in humans. Salivary alpha-amylase (sAA) is a digestive enzyme mainly responsible for the hydrolysis of starch and glycogen in the oral cavity. Since the secretion of sAA is largely under the control of the sympathetic nervous system, sAA activity is also considered to be a non-invasive marker of sympathetic activation. However, the direct association between sAA activity and other sympathetic

2018 Biological psychology

6. Effect of Intravenous or Perivascular Injection of Synthetic Adrenocorticotropic Hormone on Stimulation Test Results in Dogs (PubMed)

Effect of Intravenous or Perivascular Injection of Synthetic Adrenocorticotropic Hormone on Stimulation Test Results in Dogs Standard protocols for adrenocorticotropic hormone (ACTH) stimulation testing (ACTHst) often involve intravenous (IV) injection of corticotropin. ACTH might be unintentionally injected into the perivascular (PV) space.To compare stimulation test results after IV and PV injections of ACTH.Twenty privately owned dogs were studied: 10 healthy and 10 with trilostane-treated (...) stimulation test results in healthy dogs or in dogs with HAC undergoing therapy with trilostane.Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

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2017 Journal of Veterinary Internal Medicine

7. Corticotropin Stimulation Test

Corticotropin Stimulation Test Corticotropin Stimulation Test Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Corticotropin (...) Stimulation Test Corticotropin Stimulation Test Aka: Corticotropin Stimulation Test , Cosyntropin Stimulation Test , ACTH Stimulation Test II. Indications evaluation 8am level decreased III. Technique Obtain Baseline Labs Plasma Adrenocorticotropic Hormone (ACTH) Level level Plasma aldosterone Plasma renin activity Administer cosyntropin (ACTH) Administer ACTH 250 mcg IV Repeat Obtain at 30 and 60 minutes after IV ACTH IV. Interpretation Low cortisol level (<18 mcg/dl) and high plasma ACTH (>50 pg/ml

2015 FP Notebook

8. [Relative adrenal insufficiency in septic shock: comparison of the response to hydrocortisone in patients diagnosed through random cortisol measurement versus corticotropin test]. (PubMed)

[Relative adrenal insufficiency in septic shock: comparison of the response to hydrocortisone in patients diagnosed through random cortisol measurement versus corticotropin test]. The incidence of relative adrenal insufficiency (RAI) in patients with septic shock is high and has a significant impact on survival. The purpose of this study was to determine whether a random cortisol concentration < 25 mg/dL was as good as a low dose (1 mg) corticotrophin stimulation test in the diagnosis of RAI (...) in patients with septic shock as assessed by the hemodynamic response to hydrocortisone.Patients were randomized to a single cortisol determination or to a low dose corticotrophin stimulation test. After blood collection to cortisol determinations, hydrocortisone (100 mg every 8 hrs) was administered for all patients in the first 36 hours. RAI was defined by a random cortisol concentration < 25 mg/dL or a D cortisol concentration < 9 mg/dL in the corticotrophin test.Sixty patients (G1 = 30; G2 = 30) were

2014 Revista brasileira de terapia intensiva

9. Differential Activation in Amygdala and Plasma Noradrenaline during Colorectal Distention by Administration of Corticotropin-Releasing Hormone between Healthy Individuals and Patients with Irritable Bowel Syndrome (PubMed)

Differential Activation in Amygdala and Plasma Noradrenaline during Colorectal Distention by Administration of Corticotropin-Releasing Hormone between Healthy Individuals and Patients with Irritable Bowel Syndrome Irritable bowel syndrome (IBS) often comorbids mood and anxiety disorders. Corticotropin-releasing hormone (CRH) is a major mediator of the stress response in the brain-gut axis, but it is not clear how CRH agonists change human brain responses to interoceptive stimuli. We tested (...) adrenocorticotropic hormone (ACTH), serum cortisol and plasma noradrenaline levels were measured at each stimulation. At baseline, CRH without colorectal distention induced more activation in the right amygdala in IBS patients than in controls. During intense distention after CRH injection, controls showed significantly greater activation than IBS patients in the right amygdala. Plasma ACTH and serum cortisol secretion showed a significant interaction between drug (CRH, saline) and distention. Plasma

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2016 PloS one

10. A Search for Variables Predicting Cortisol Response to Low-Dose Corticotropin Stimulation Following Supraphysiological Doses of Glucocorticoids. (PubMed)

A Search for Variables Predicting Cortisol Response to Low-Dose Corticotropin Stimulation Following Supraphysiological Doses of Glucocorticoids. To determine which biological or clinical variables may predict cortisol response to low-dose adrenocorticotropic hormone (ACTH) stimulation following supraphysiological doses of glucocorticoids in children.This retrospective study included all patients who underwent ACTH testing (1 μg) between October 2008 and June 2010 at the Sainte-Justine (...) (median, 374 days; range, 5-4226 days); duration of physiological hydrocortisone replacement (median, 118 days; range, 0-1089 days); maximum daily (median, 200 mg/m(2)/day; range, 12-3750 mg/m(2)/day) and cumulative (median, 16 728 mg/m(2); range, 82-178 209 mg/m(2)) doses, in hydrocortisone equivalents; and interval since the last dose (median, 43 days; range, 1-1584 days). Sixty-two patients (58%) exhibited a normal response (ie, peak cortisol >500 nmol/L) to ACTH stimulation. Peak cortisol level

2013 Journal of Pediatrics

11. Corticotropin Releasing Hormone (CRH) Responsiveness in Children With Functional Dyspepsia

dyspepsia react to CRH, we will do a CRH stimulation test. A CRH stimulation test is routinely done in endocrine patients. It is not routinely done for patients with functional dyspepsia or for patients who do not have functional dyspepsia. Part of the CRH stimulation test is giving a synthetic type of corticotropin, Acthrel® (brand name for Corticorelin), as injection. Acthrel® has been approved by the Food and Drug Administration (FDA) for use. The purpose of this research study is to see (...) if there are differences in how the bodies of children with functional dyspepsia react to CRH versus children who don't have functional dyspepsia. Being in this study involves one clinic visit where an IV placed and a CRH stimulation test. In this test the child will be given an injection of CRH and then observed for one hour. During that hour the child will have five blood draws through the IV and will be asked questions about their anxiety and abdominal pain. This visit will take about 4 hours. The following things

2011 Clinical Trials

12. Alterations in response of rat white adipocytes to insulin, noradrenaline, corticotropin and glucagon after adrenalectomy. Correction of these changes by adenosine deaminase. (PubMed)

. Adipocytes from adrenalectomized rats had decreased lipolytic responses to all concentrations of noradrenaline and glucagon tested and a decreased lipolytic response to low but not high concentrations of corticotropin. There was no difference in lipolytic response to theophylline after adrenalectomy. Adenosine deaminase corrected the differences in response to noradrenaline and glucagon resulting from adrenalectomy. 3. In the presence of adenosine deaminase rates of lipolysis, after stimulation by high (...) Alterations in response of rat white adipocytes to insulin, noradrenaline, corticotropin and glucagon after adrenalectomy. Correction of these changes by adenosine deaminase. 1. Adipocytes isolated from rats 6--9 days after adrenalectomy had significantly increased sensitivity to insulin action against noradrenaline-stimulated lipolysis. In the presence of adenosine deaminase there was no significant difference in insulin sensitivity between cells from adrenalectomized and sham-operated rats. 2

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1978 Biochemical Journal

13. Corticosteroid secretion: responses to 1-24 corticotropin, metyrapone and dexamethasone. (PubMed)

Adrenocorticotropic Hormone WI4X0X7BPJ Hydrocortisone ZS9KD92H6V Metyrapone IM Adrenal Cortex Hormones administration & dosage metabolism Adrenal Glands drug effects physiology Adrenocorticotropic Hormone metabolism pharmacology Circadian Rhythm Dexamethasone pharmacology Humans Hydrocortisone blood Hypothalamus physiology Metyrapone pharmacology Pituitary Gland physiology Pituitary-Adrenal Function Tests Stimulation, Chemical 1972 1 1 1972 1 1 0 1 1972 1 1 0 0 ppublish 4339147 PMC2441267 Arch Intern Med. 1966 (...) Corticosteroid secretion: responses to 1-24 corticotropin, metyrapone and dexamethasone. 4339147 1972 09 05 2018 11 30 0065-7778 83 1972 Transactions of the American Clinical and Climatological Association Trans. Am. Clin. Climatol. Assoc. Corticosteroid secretion: responses to alpha1-24 corticotropin, metyrapone and dexamethasone. 45-56 Frawley T F TF eng Journal Article United States Trans Am Clin Climatol Assoc 7507559 0065-7778 0 Adrenal Cortex Hormones 7S5I7G3JQL Dexamethasone 9002-60-2

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1972 Transactions Of The American Clinical And Climatological Association

14. ACTH after 15 minutes distinguishes between Cushing's disease and ectopic Cushing's syndrome: A proposal for a short and simple CRH test. (PubMed)

ACTH after 15 minutes distinguishes between Cushing's disease and ectopic Cushing's syndrome: A proposal for a short and simple CRH test. The aim of the present study was to validate criteria of corticotropin-releasing hormone (CRH) stimulation and 8 mg dexamethasone suppression (high-dose dexamethasone suppression, HDDS) to distinguish the etiology of ACTH-dependent Cushing's syndrome.We retrospectively analyzed cortisol and ACTH after the injection of 100 μg human CRH in confirmed Cushing's (...) of 14.0, a sensitivity of 83%, a specificity of 94%, a positive predictive value of 98% and a negative predictive value of 58%. All of the other criteria of stimulated ACTH and cortisol levels were not superior in predicting CD in response to CRH injection. The addition of cortisol suppression by dexamethasone did not increase the discriminatory power. However, the combination of a positive ACTH response at 15 min and a positive HDDS test excluded ECS in all cases.The present findings support the use

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2015 European Journal of Endocrinology

15. 3 Tesla magnetic resonance imaging with and without corticotropin releasing hormone stimulation for the detection of microadenomas in Cushing's syndrome. (PubMed)

3 Tesla magnetic resonance imaging with and without corticotropin releasing hormone stimulation for the detection of microadenomas in Cushing's syndrome. We sought to determine if higher resolution 3 Tesla (T) magnetic resonance imaging (MRI) with or without ovine corticotropin releasing hormone (o-CRH) stimulation would increase the sensitivity for detection of pituitary microadenomas in ACTH-dependent Cushing's syndrome (CS).We prospectively identified 23 patients over a 2-year period (...) 3T MRI without (P < 0.016) and with o-CRH stimulation (P < 0.013) was significantly more sensitive for detection of pituitary microadenomas than 1.5T MRI for Group 1 (definitive proof of Cushing's disease, n = 10). Group 2 (those in group 1, plus three patients where dynamic/invasive testing suggested pituitary source) also showed a significant (P < 0.012) advantage for 3T. There was no difference between the 3T and the 3T o-CRH examinations for any of the pulse sequences. We did not observe

2010 Clinical endocrinology

16. The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine responses in human blood and is sorted into placental exosomes. (PubMed)

The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine responses in human blood and is sorted into placental exosomes. To examine whether syncytin-1 has immune regulatory functions and is carried by human placental exosomes. Further, to examine whether corticotropin-releasing hormone (CRH) can induce the production of syncytin-1.Human placental exosomes were isolated from placental explant, primary trophoblast and BeWo cell cultures. The presence of exosomes (...) was confirmed by transmission electron microscopy and western blotting. Exosomal protein was probed with 3 separate antibodies targeting syncytin-1. Syncytin-1 immunosuppression was tested, using either a syncytin-1 recombinant ectodomain protein or a synthetic peptide with the human syncytin-1 immunosuppressive domain sequence, in an in vitro human blood culture system immune challenged with LPS or PHA. The inhibition of cytokine production by syncytin-1 was determined by ELISA of TNF-α, IFN-γ and CXCL10

2012 Placenta

17. ACTH stimulation test

ACTH stimulation test ACTH stimulation test - Wikipedia ACTH stimulation test From Wikipedia, the free encyclopedia ACTH stimulation test , The ACTH test (also called the cosyntropin , tetracosactide , or Synacthen test ) is a usually ordered and interpreted by to assess the functioning of the stress response by measuring the adrenal response to (ACTH; corticotropin) or another such as (cosyntropin, tetracosactrin; Synacthen) or (Synchrodyn). ACTH is a hormone produced in the that stimulates (...) production) or pituitary (low ACTH production). The is recognized as the gold standard assay of adrenal insufficiency, but due to the cumbersome requirement for a two-hour test and the risks of seizures or myocardial infarction, the ACTH stimulation test is commonly used as an easier, safer, though not as accurate, alternative. The test is extremely sensitive (97% at 95% specificity) to primary adrenal insufficiency, but less so to secondary adrenal insufficiency (57-61% at 95% specificity); while

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2012 Wikipedia

18. Effects of Hormone Stimulation on Brain Scans for Cushing s Disease

the tumors more active. Objectives: - To test the use of hormone stimulation to improve brain scans for Cushing s disease tumors. Eligibility: - Individuals at least 8 years of age who will be having surgery to remove Cushing s disease tumors. Design: Participants will be screened with a medical history, physical exam, blood and urine tests, and imaging studies. They will have three brain scans before surgery. The first scan is a magnetic resonance imaging scan to show a full picture of the brain (...) table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 30 participants Allocation: Randomized Intervention Model: Single Group Assignment Masking: Single (Participant) Primary Purpose: Diagnostic Official Title: Prospective Evaluation of the Effect of Corticotropin-Releasing Hormone Stimulation on 18F-Fludeoxyglucose High-Resolution Positron-Emission Tomography in Cushing's Disease Study Start Date : October 11, 2011 Actual Primary Completion Date : January 30

2011 Clinical Trials

19. Corticosteroids in Sepsis Now Less Stimulating

Corticosteroids in Sepsis Now Less Stimulating Corticosteroids in Sepsis Now Less Stimulating – Clinical Correlations Search Corticosteroids in Sepsis Now Less Stimulating April 30, 2008 4 min read Commentary by Joe Philip MD, PGY-2 CORTICUS was the long-awaited trial addressing the use of corticosteroids in sepsis that was this past January. Months prior to the leading auther Charles Sprung publishing it, the Tisch and Bellevue intensive care units halted corticotropin stimulation testing (...) for the use of steroids in sepsis. But it was the Annane studies in 2000 and 2002 that determined first the prognostic value in corticotropin stimulation as well as the fact that treatment of those relatively adrenally insufficient led to decreased time off vasopressors, reduced 28-day and 1-year mortality rates. So why should we think twice about using corticosteroids in septic patients since CORTICUS? Corticosteroids showed no mortality benefit and the corticotropin test was of no value in predicting

2008 Clinical Correlations

20. Effects of Corticotropin-Releasing Hormone Receptor 1 (CRH1) Antagonism on Stress-Induced Craving in Alcoholic Women With High Anxiety

with simultaneous follicle stimulating hormone (FSH) > 40 MlU/ml and estradiol < 40 pg/ml (<140 pmol/L) is confirmatory]; or, of child-bearing potential, has a negative serum pregnancy test both on screening and during placebo lead-in, and agrees to one of the following methods of contraception: i. Practices complete abstinence from intercourse two weeks prior to administration of study drug, throughout participating in the clinical trial and for two weeks following discontinuation of the study medication (...) Effects of Corticotropin-Releasing Hormone Receptor 1 (CRH1) Antagonism on Stress-Induced Craving in Alcoholic Women With High Anxiety CRF1 Antagonist GSK561679 in Alcoholism - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2010 Clinical Trials

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