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Corticotropin Stimulation Test

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1. Salivary Cortisol and Cortisone After Low-Dose Corticotropin Stimulation in the Diagnosis of Adrenal Insufficiency Full Text available with Trip Pro

Salivary Cortisol and Cortisone After Low-Dose Corticotropin Stimulation in the Diagnosis of Adrenal Insufficiency Basal and poststimulation salivary cortisol and cortisone levels can be useful in the diagnosis of adrenal insufficiency. However, little is known about the optimal cutoffs and performance characteristics of these tests.To derive the cutoff values and study the performance characteristics of salivary cortisol and salivary cortisone in the diagnosis of adrenal (...) insufficiency.Prospective study in a regional hospital in Hong Kong from January 2014 to September 2015.Fifty-six Chinese healthy volunteers and 171 patients suspected of having adrenal insufficiency.All participants underwent low-dose short Synacthen test (LDSST) with intravenous injection of 1 μg of tetracosactide (Synacthen 1-24). Serum cortisol, salivary cortisol and cortisone levels were measured at baseline and 30 and 60 minutes afterward.Using the reference cutoff (mean - 2 standard deviations of post-LDSST peak

2017 Journal of the Endocrine Society

2. Corticotropin Stimulation Test

Corticotropin Stimulation Test Corticotropin Stimulation Test Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Corticotropin (...) Stimulation Test Corticotropin Stimulation Test Aka: Corticotropin Stimulation Test , Cosyntropin Stimulation Test , ACTH Stimulation Test II. Indications evaluation 8am level decreased III. Technique Obtain Baseline Labs Plasma Adrenocorticotropic Hormone (ACTH) Level level Plasma aldosterone Plasma renin activity Administer cosyntropin (ACTH) Administer ACTH 250 mcg IV Repeat Obtain at 30 and 60 minutes after IV ACTH IV. Interpretation Low cortisol level (<18 mcg/dl) and high plasma ACTH (>50 pg/ml

2018 FP Notebook

3. Estradiol-dependent stimulation and suppression of gonadotropin-releasing hormone (GnRH) neuron firing activity by corticotropin-releasing hormone (CRH) in female mice. Full Text available with Trip Pro

Estradiol-dependent stimulation and suppression of gonadotropin-releasing hormone (GnRH) neuron firing activity by corticotropin-releasing hormone (CRH) in female mice. Gonadotropin-releasing hormone (GnRH) neurons are the final central regulators of reproduction, integrating various inputs that modulate fertility. Stress typically inhibits reproduction but can be stimulatory; stress effects can also be modulated by steroid milieu. Corticotropin-releasing hormone (CRH) released during (...) the stress response may suppress reproduction independent of downstream glucocorticoids. We hypothesized CRH suppresses fertility by decreasing GnRH neuron firing activity. To test this, mice were ovariectomized (OVX) and either implanted with an estradiol capsule (OVX+E) or not treated further to examine the influence of estradiol on GnRH neuron response to CRH. Targeted extracellular recordings were used to record firing activity from green fluorescent protein-identified GnRH neurons in brain slices

2017 Endocrinology

4. Corticotropin-releasing factor stimulates colonic motility via muscarinic receptors in the rat Full Text available with Trip Pro

Corticotropin-releasing factor stimulates colonic motility via muscarinic receptors in the rat To measure exogenous corticotropin-releasing factor (CRF)-induced motility of the isolated rat colon and to demonstrate the effect of pharmacologic inhibition on CRF-induced motility.The isolated vascularly-perfused rat colon was used. Luminal pressure was monitored via microtip catheter pressure transducers in the proximal and distal colon. At first, exogenous CRF was administered in a stepwise (...) manner and the concentration of CRF yielding maximal colonic motility was selected. After recording basal colonic motility, hexamethonium, phentolamine, propranolol, atropine and tetrodotoxin were infused into the isolated colon. Initially, only the test drug was infused; then, CRF was added. The motility index was expressed as percentage change over basal level.Administration of 1.4, 14.4, 144 and 288 pmol/L CRF progressively increased colonic motility in the proximal and distal colon. Infusion

2017 World Journal of Gastroenterology

5. Salivary alpha-amylase and noradrenaline responses to corticotropin-releasing hormone administration in humans. (Abstract)

parameters remains questionable. Therefore, we employed the corticotropin-releasing hormone (CRH) stimulation test to pharmacologically activate the sympathetic nervous system and to analyze plasma noradrenaline response together with sAA activity. Thirty-one healthy male volunteers (mean age of 25.2±3.1years) were randomized into two groups and received injections with either CRH (100μg, N=17) or placebo (0.9% NaCl, N=14). Blood samples were taken at baseline and 15, 30, 60, 120min after injection (...) Salivary alpha-amylase and noradrenaline responses to corticotropin-releasing hormone administration in humans. Salivary alpha-amylase (sAA) is a digestive enzyme mainly responsible for the hydrolysis of starch and glycogen in the oral cavity. Since the secretion of sAA is largely under the control of the sympathetic nervous system, sAA activity is also considered to be a non-invasive marker of sympathetic activation. However, the direct association between sAA activity and other sympathetic

2018 Biological psychology Controlled trial quality: uncertain

6. Effect of Intravenous or Perivascular Injection of Synthetic Adrenocorticotropic Hormone on Stimulation Test Results in Dogs Full Text available with Trip Pro

Effect of Intravenous or Perivascular Injection of Synthetic Adrenocorticotropic Hormone on Stimulation Test Results in Dogs Standard protocols for adrenocorticotropic hormone (ACTH) stimulation testing (ACTHst) often involve intravenous (IV) injection of corticotropin. ACTH might be unintentionally injected into the perivascular (PV) space.To compare stimulation test results after IV and PV injections of ACTH.Twenty privately owned dogs were studied: 10 healthy and 10 with trilostane-treated (...) stimulation test results in healthy dogs or in dogs with HAC undergoing therapy with trilostane.Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

2017 Journal of Veterinary Internal Medicine

7. Corticotropin Stimulation Test

Corticotropin Stimulation Test Corticotropin Stimulation Test Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Corticotropin (...) Stimulation Test Corticotropin Stimulation Test Aka: Corticotropin Stimulation Test , Cosyntropin Stimulation Test , ACTH Stimulation Test II. Indications evaluation 8am level decreased III. Technique Obtain Baseline Labs Plasma Adrenocorticotropic Hormone (ACTH) Level level Plasma aldosterone Plasma renin activity Administer cosyntropin (ACTH) Administer ACTH 250 mcg IV Repeat Obtain at 30 and 60 minutes after IV ACTH IV. Interpretation Low cortisol level (<18 mcg/dl) and high plasma ACTH (>50 pg/ml

2015 FP Notebook

8. [Relative adrenal insufficiency in septic shock: comparison of the response to hydrocortisone in patients diagnosed through random cortisol measurement versus corticotropin test]. (Abstract)

[Relative adrenal insufficiency in septic shock: comparison of the response to hydrocortisone in patients diagnosed through random cortisol measurement versus corticotropin test]. The incidence of relative adrenal insufficiency (RAI) in patients with septic shock is high and has a significant impact on survival. The purpose of this study was to determine whether a random cortisol concentration < 25 mg/dL was as good as a low dose (1 mg) corticotrophin stimulation test in the diagnosis of RAI (...) in patients with septic shock as assessed by the hemodynamic response to hydrocortisone.Patients were randomized to a single cortisol determination or to a low dose corticotrophin stimulation test. After blood collection to cortisol determinations, hydrocortisone (100 mg every 8 hrs) was administered for all patients in the first 36 hours. RAI was defined by a random cortisol concentration < 25 mg/dL or a D cortisol concentration < 9 mg/dL in the corticotrophin test.Sixty patients (G1 = 30; G2 = 30) were

2014 Revista brasileira de terapia intensiva Controlled trial quality: uncertain

9. A Search for Variables Predicting Cortisol Response to Low-Dose Corticotropin Stimulation Following Supraphysiological Doses of Glucocorticoids. (Abstract)

A Search for Variables Predicting Cortisol Response to Low-Dose Corticotropin Stimulation Following Supraphysiological Doses of Glucocorticoids. To determine which biological or clinical variables may predict cortisol response to low-dose adrenocorticotropic hormone (ACTH) stimulation following supraphysiological doses of glucocorticoids in children.This retrospective study included all patients who underwent ACTH testing (1 μg) between October 2008 and June 2010 at the Sainte-Justine (...) (median, 374 days; range, 5-4226 days); duration of physiological hydrocortisone replacement (median, 118 days; range, 0-1089 days); maximum daily (median, 200 mg/m(2)/day; range, 12-3750 mg/m(2)/day) and cumulative (median, 16 728 mg/m(2); range, 82-178 209 mg/m(2)) doses, in hydrocortisone equivalents; and interval since the last dose (median, 43 days; range, 1-1584 days). Sixty-two patients (58%) exhibited a normal response (ie, peak cortisol >500 nmol/L) to ACTH stimulation. Peak cortisol level

2013 Journal of Pediatrics

10. Differential Activation in Amygdala and Plasma Noradrenaline during Colorectal Distention by Administration of Corticotropin-Releasing Hormone between Healthy Individuals and Patients with Irritable Bowel Syndrome Full Text available with Trip Pro

Differential Activation in Amygdala and Plasma Noradrenaline during Colorectal Distention by Administration of Corticotropin-Releasing Hormone between Healthy Individuals and Patients with Irritable Bowel Syndrome Irritable bowel syndrome (IBS) often comorbids mood and anxiety disorders. Corticotropin-releasing hormone (CRH) is a major mediator of the stress response in the brain-gut axis, but it is not clear how CRH agonists change human brain responses to interoceptive stimuli. We tested (...) adrenocorticotropic hormone (ACTH), serum cortisol and plasma noradrenaline levels were measured at each stimulation. At baseline, CRH without colorectal distention induced more activation in the right amygdala in IBS patients than in controls. During intense distention after CRH injection, controls showed significantly greater activation than IBS patients in the right amygdala. Plasma ACTH and serum cortisol secretion showed a significant interaction between drug (CRH, saline) and distention. Plasma

2016 PloS one

11. Alterations in response of rat white adipocytes to insulin, noradrenaline, corticotropin and glucagon after adrenalectomy. Correction of these changes by adenosine deaminase. Full Text available with Trip Pro

. Adipocytes from adrenalectomized rats had decreased lipolytic responses to all concentrations of noradrenaline and glucagon tested and a decreased lipolytic response to low but not high concentrations of corticotropin. There was no difference in lipolytic response to theophylline after adrenalectomy. Adenosine deaminase corrected the differences in response to noradrenaline and glucagon resulting from adrenalectomy. 3. In the presence of adenosine deaminase rates of lipolysis, after stimulation by high (...) Alterations in response of rat white adipocytes to insulin, noradrenaline, corticotropin and glucagon after adrenalectomy. Correction of these changes by adenosine deaminase. 1. Adipocytes isolated from rats 6--9 days after adrenalectomy had significantly increased sensitivity to insulin action against noradrenaline-stimulated lipolysis. In the presence of adenosine deaminase there was no significant difference in insulin sensitivity between cells from adrenalectomized and sham-operated rats. 2

1978 Biochemical Journal

12. Corticosteroid secretion: responses to 1-24 corticotropin, metyrapone and dexamethasone. Full Text available with Trip Pro

Adrenocorticotropic Hormone WI4X0X7BPJ Hydrocortisone ZS9KD92H6V Metyrapone IM Adrenal Cortex Hormones administration & dosage metabolism Adrenal Glands drug effects physiology Adrenocorticotropic Hormone metabolism pharmacology Circadian Rhythm Dexamethasone pharmacology Humans Hydrocortisone blood Hypothalamus physiology Metyrapone pharmacology Pituitary Gland physiology Pituitary-Adrenal Function Tests Stimulation, Chemical 1972 1 1 1972 1 1 0 1 1972 1 1 0 0 ppublish 4339147 PMC2441267 Arch Intern Med. 1966 (...) Corticosteroid secretion: responses to 1-24 corticotropin, metyrapone and dexamethasone. 4339147 1972 09 05 2018 11 30 0065-7778 83 1972 Transactions of the American Clinical and Climatological Association Trans. Am. Clin. Climatol. Assoc. Corticosteroid secretion: responses to alpha1-24 corticotropin, metyrapone and dexamethasone. 45-56 Frawley T F TF eng Journal Article United States Trans Am Clin Climatol Assoc 7507559 0065-7778 0 Adrenal Cortex Hormones 7S5I7G3JQL Dexamethasone 9002-60-2

1972 Transactions Of The American Clinical And Climatological Association

13. ACTH after 15 minutes distinguishes between Cushing's disease and ectopic Cushing's syndrome: A proposal for a short and simple CRH test. Full Text available with Trip Pro

ACTH after 15 minutes distinguishes between Cushing's disease and ectopic Cushing's syndrome: A proposal for a short and simple CRH test. The aim of the present study was to validate criteria of corticotropin-releasing hormone (CRH) stimulation and 8 mg dexamethasone suppression (high-dose dexamethasone suppression, HDDS) to distinguish the etiology of ACTH-dependent Cushing's syndrome.We retrospectively analyzed cortisol and ACTH after the injection of 100 μg human CRH in confirmed Cushing's (...) of 14.0, a sensitivity of 83%, a specificity of 94%, a positive predictive value of 98% and a negative predictive value of 58%. All of the other criteria of stimulated ACTH and cortisol levels were not superior in predicting CD in response to CRH injection. The addition of cortisol suppression by dexamethasone did not increase the discriminatory power. However, the combination of a positive ACTH response at 15 min and a positive HDDS test excluded ECS in all cases.The present findings support the use

2015 European Journal of Endocrinology

14. Acupuncture Stimulation Attenuates Impaired Emotional-Like Behaviors and Activation of the Noradrenergic System during Protracted Abstinence following Chronic Morphine Exposure in Rats. Full Text available with Trip Pro

was injected once to extend despair-related withdrawal behaviors for 4 weeks. Acupuncture stimulation was performed once at the SP6 (Sanyinjiao) acupoint on rat's; hind leg for 5 min during protracted abstinence from morphine. The acupuncture stimulation significantly decreased despair-like behavior deficits in the forced swimming test and low sociability in the open-field test as well as increased open-arm exploration in the elevated plus maze test in the last week of 4-week withdrawal period. Also (...) the acupuncture stimulation significantly suppressed the increase in the hypothalamic corticotropin-releasing factor (CRF) expression, the decrease in the tyrosine hydroxylase expression in the locus coeruleus, and the decrease in the hippocampal brain-derived neurotrophic factor mRNA expression, induced by repeated injection of morphine. Taken together, these findings demonstrate that the acupuncture stimulation of SP6 significantly reduces withdrawal-induced behaviors, induced by repeated administration

2014 Evidence-based Complementary and Alternative Medicine (eCAM)

15. The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine responses in human blood and is sorted into placental exosomes. (Abstract)

The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine responses in human blood and is sorted into placental exosomes. To examine whether syncytin-1 has immune regulatory functions and is carried by human placental exosomes. Further, to examine whether corticotropin-releasing hormone (CRH) can induce the production of syncytin-1.Human placental exosomes were isolated from placental explant, primary trophoblast and BeWo cell cultures. The presence of exosomes (...) was confirmed by transmission electron microscopy and western blotting. Exosomal protein was probed with 3 separate antibodies targeting syncytin-1. Syncytin-1 immunosuppression was tested, using either a syncytin-1 recombinant ectodomain protein or a synthetic peptide with the human syncytin-1 immunosuppressive domain sequence, in an in vitro human blood culture system immune challenged with LPS or PHA. The inhibition of cytokine production by syncytin-1 was determined by ELISA of TNF-α, IFN-γ and CXCL10

2012 Placenta

16. Corticotropin Releasing Hormone (CRH) Responsiveness in Children With Functional Dyspepsia

dyspepsia react to CRH, we will do a CRH stimulation test. A CRH stimulation test is routinely done in endocrine patients. It is not routinely done for patients with functional dyspepsia or for patients who do not have functional dyspepsia. Part of the CRH stimulation test is giving a synthetic type of corticotropin, Acthrel® (brand name for Corticorelin), as injection. Acthrel® has been approved by the Food and Drug Administration (FDA) for use. The purpose of this research study is to see (...) if there are differences in how the bodies of children with functional dyspepsia react to CRH versus children who don't have functional dyspepsia. Being in this study involves one clinic visit where an IV placed and a CRH stimulation test. In this test the child will be given an injection of CRH and then observed for one hour. During that hour the child will have five blood draws through the IV and will be asked questions about their anxiety and abdominal pain. This visit will take about 4 hours. The following things

2011 Clinical Trials

17. ACTH stimulation test Full Text available with Trip Pro

ACTH stimulation test ACTH stimulation test - Wikipedia ACTH stimulation test From Wikipedia, the free encyclopedia ACTH stimulation test , The ACTH test (also called the cosyntropin , tetracosactide , or Synacthen test ) is a usually ordered and interpreted by to assess the functioning of the stress response by measuring the adrenal response to (ACTH; corticotropin) or another such as (cosyntropin, tetracosactrin; Synacthen) or (Synchrodyn). ACTH is a hormone produced in the that stimulates (...) production) or pituitary (low ACTH production). The is recognized as the gold standard assay of adrenal insufficiency, but due to the cumbersome requirement for a two-hour test and the risks of seizures or myocardial infarction, the ACTH stimulation test is commonly used as an easier, safer, though not as accurate, alternative. The test is extremely sensitive (97% at 95% specificity) to primary adrenal insufficiency, but less so to secondary adrenal insufficiency (57-61% at 95% specificity); while

2012 Wikipedia

18. 3 Tesla magnetic resonance imaging with and without corticotropin releasing hormone stimulation for the detection of microadenomas in Cushing's syndrome. (Abstract)

3 Tesla magnetic resonance imaging with and without corticotropin releasing hormone stimulation for the detection of microadenomas in Cushing's syndrome. We sought to determine if higher resolution 3 Tesla (T) magnetic resonance imaging (MRI) with or without ovine corticotropin releasing hormone (o-CRH) stimulation would increase the sensitivity for detection of pituitary microadenomas in ACTH-dependent Cushing's syndrome (CS).We prospectively identified 23 patients over a 2-year period (...) 3T MRI without (P < 0.016) and with o-CRH stimulation (P < 0.013) was significantly more sensitive for detection of pituitary microadenomas than 1.5T MRI for Group 1 (definitive proof of Cushing's disease, n = 10). Group 2 (those in group 1, plus three patients where dynamic/invasive testing suggested pituitary source) also showed a significant (P < 0.012) advantage for 3T. There was no difference between the 3T and the 3T o-CRH examinations for any of the pulse sequences. We did not observe

2010 Clinical endocrinology Controlled trial quality: uncertain

19. Adrenal suppression

endogenous glucocorticoid excess (e.g., Cushing's syndrome after treatment). Even locally administered glucocorticoids may result in adrenal suppression. The adrenocorticotropic hormone stimulation test is generally the most useful test to detect adrenal suppression. Treatment consists of augmented corticosteroid therapy plus supportive care for any intercurrent stress or overt signs of adrenal insufficiency. Preventive measures include minimising corticosteroid dose and duration when possible (...) weeks non-physiological scheduling of glucocorticoid dose megestrol use medroxyprogesterone use Diagnostic investigations serum comprehensive chemistry panel serum a.m. cortisol salivary a.m. cortisol adrenocorticotropic hormone (ACTH) stimulation test insulin tolerance test (ITT) overnight metyrapone test urine synthetic glucocorticoids Treatment algorithm INITIAL ACUTE ONGOING Contributors Authors Associate Professor Department of Endocrinology Cleveland Clinic Foundation Cleveland OH Disclosures

2018 BMJ Best Practice

20. Diagnosis and Treatment of Non-Neurogenic Overactive Bladder (OAB) in Adults

-line treatment in the carefully-selected and thoroughly-counseled patient who has been refractory to first- and second-line OAB treatments. The patient must be able and willing to return for frequent post-void residual evaluation and able and willing to perform self-catheterization if necessary. Standard (Evidence Strength Grade B) 19. Clinicians may offer peripheral tibial nerve stimulation (PTNS) as third-line treatment in a carefully selected patient population. Recommendation (Evidence Strength (...) to the database. Given that the AHRQ report included limited information regarding use of neuromodulation therapies, including sacral neuromodulation (SNS) and peripheral tibial nerve stimulation (PTNS) (also known as posterior tibial nerve stimulation) and limited information regarding the use of intravesical onabotulinumtoxinA to treat non-neurogenic OAB patients, additional searches were performed to capture this literature and relevant data were added to the database. The AUA update literature review

2019 American Urological Association

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