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Corneal Reflex

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141. The Anticipated Organ Donation Approach

or Female over 18 years-old patients with serious brain damages medical decision of withdrawing life sustaining treatment Signed and dated informed consent by trusted person, or family Patient covered by social security regimen Glasgow Coma Scale (GCS) : Patient with serious brain-injured without confounding factors, without head trauma or brain anoxia : GCS<5 and loss of the corneal reflex or GCS<5 and loss of the brainstem reflex Patient with serious brain-injured with confounding factors, without (...) head trauma and brain anoxia : GCS<7 with a least one scanographic sign of gravity Deletion of the subarachnoid cisterns Deviation of the median line of more than 15 mm Hematoma volume < 65 cm3 Secondary hydrocephalus to an intra-ventricular bleeding with V3 or V4 flood. o Patient with head trauma or brain anoxia (no confounding factor) with reliable clinical examination required : GCS<5 and loss of the corneal reflex or GCS<5 and loss of the brainstem reflex Exclusion Criteria: No trusted person

2018 Clinical Trials

142. A holographic waveguide based eye tracker Full Text available with Trip Pro

collimator. The waveguide captured images of the anterior segment of the eye right in front of it and guided the images to a processing unit distant from the eye. The vector connecting the pupil center (PC) and the corneal reflex (CR) of the eye was used to compute eye position in the socket. An eye model, made of a high quality prosthetic eye, was used prototype validation. The benchtop prototype demonstrated a linear relationship between the angular eye position and the PC/CR vector over a range of 60

2018 Proceedings of SPIE--the International Society for Optical Engineering

143. TRPV1 and TRPM8 Channels and Nocifensive Behavior in a Rat Model for Dry Eye. Full Text available with Trip Pro

TRPV1 and TRPM8 Channels and Nocifensive Behavior in a Rat Model for Dry Eye. Persistent ocular surface pain occurs in moderate to severe dry eye disease (DE); however, the mechanisms that underlie this symptom remain uncertain. The aim of this study was to determine if the transient receptor potential vanilloid ion channels play a role in hypertonic saline (HS)-evoked corneal reflexes in a model for aqueous tear deficient DE.Eye wipe behavior and orbicularis oculi muscle activity (OOemg) were (...) to target specific transducer molecules on corneal nerves may prove beneficial as adjunct therapies in managing ocular pain in moderate to severe cases of DE.

2018 Investigative Ophthalmology & Visual Science

144. Prognostication after cardiac arrest Full Text available with Trip Pro

Prognostication after cardiac arrest Hypoxic-ischaemic brain injury (HIBI) is the main cause of death in patients who are comatose after resuscitation from cardiac arrest. A poor neurological outcome-defined as death from neurological cause, persistent vegetative state, or severe neurological disability-can be predicted in these patients by assessing the severity of HIBI. The most commonly used indicators of severe HIBI include bilateral absence of corneal and pupillary reflexes, bilateral

2018 Critical Care

145. Neurotrophic keratitis: current challenges and future prospects Full Text available with Trip Pro

Neurotrophic keratitis: current challenges and future prospects Neurotrophic keratitis (NK) is a degenerative corneal disease caused by damage of trigeminal corneal innervation, which leads to spontaneous epithelial breakdown and corneal ulceration. The impairment of corneal sensory innervation causes the reduction of both protective reflexes and trophic neuromodulators that are essential for the vitality, metabolism, and wound healing of ocular surface tissues. A wide range of ocular (...) and systemic conditions, including herpetic keratitis, ocular chemical burns, corneal surgery, diabetes, multiple sclerosis, and neurosurgical procedures, can cause NK by damaging trigeminal innervation. Diagnosis of NK requires careful investigation of any ocular and systemic condition associated with the disease, complete ocular surface examination, and quantitative measurement of corneal sensitivity. The clinical stages of NK range from corneal epithelial alterations (stage 1) to persistent epithelial

2018 Eye and brain

146. A Case of Neurotrophic Keratopathy Concomitant to Brain Metastasis Full Text available with Trip Pro

A Case of Neurotrophic Keratopathy Concomitant to Brain Metastasis We report a case of a 63-year-old Caucasian female referred to the cornea service of Clinica Oculistica with a neurotrophic corneal ulcer, decreased corneal sensitivity, absent corneal reflex, and decreased lacrimation. The medical record review was relevant for mastectomy and adjuvant therapy for breast cancer complicated by pontocerebellar angle metastasis. Eye patching and application of antibiotic and vitamin ointments were (...) prescribed at first, without a significant improvement. Thus, treatment with autologous serum was started. In about two weeks, the cornea recovered and visual acuity improved with a residual corneal scarring. Finally, we should mention that, in our case, the main cause of the neurotrophic corneal ulcer could be identified in the previous trigeminal damage at the pontocerebellar angle and trigeminal ganglion. Sensory nerves play an important regulatory role via neuro-mediators on corneal wound healing

2018 Cureus

147. Prediction of Pseudophakodonesis of Intraocular Lenses

stability. Several techniques have been used to measure IOL decentration and tilt, such as slitlamp examination, retroillumination photography, Scheimpflug imaging and the analysis of purkinje reflexes. Slitlamp examination is a subjective method that allows approximate decentration measurements, but no quantitative tilt measurements. For this measurement the pupil has to be dilated. Scheimpflug imaging also needs a sufficiently dilated pupil to make the optic edge and the posterior surface of the IOL (...) to be clinically irrelevant Written informed consent Pseudoexfoliation syndrome or history of blunt ocular trauma - for the study group Exclusion Criteria: Pseudoexfoliation syndrome or history of blunt ocular trauma - for the control group History of penetrating ocular trauma Relevant other ophthalmic diseases that could affect corneal transparency or the ability for fixation Any relevant ophthalmic disease leading to limited visual acuity prognosis after cataract surgery In case of pregnancy (pregnancy test

2018 Clinical Trials

148. Peribulbar Block: Lidocaine-bupivacaine vs Lidocaine-bupivacaine-fentanyl

of lidocaine 5%, 15 mg of 0.5% bupivacaine and 50 mcg of fentanyl citrate for a total volume of the anesthetic mixture of 6 ml. Drug: peribulbar block 2 lidocaine/bupivacaine/fentanyl Peribulbar block: 100 mg of lidocaine 5%, 15 mg of 0.5% bupivacaine and 50 mcg of fentanyl citrate for a total volume of the anesthetic mixture of 6 ml. Other Name: lidocaine/bupivacaine/fentanyl Outcome Measures Go to Primary Outcome Measures : Latency period (lost of corneal reflex) [ Time Frame: 10 minutes until the start (...) of surgery ] lost of corneal reflex Secondary Outcome Measures : Ocular akinesia: movements of extraocular muscles [ Time Frame: 10 minutes until the start of surgery ] movements of extraocular muscles Incidence of postoperative pain [ Time Frame: 2 Hours ] Analogous visual scale postoperative complications [ Time Frame: 2 hours ] bleeding or bruise Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk

2018 Clinical Trials

149. Gabapentin as Preanesthetic Medication to Fast Procedures in Pediatric´s Oncology

will be submitted to the same general anesthesia protocol, receiving sevoflurane 8% plus N2O and oxygen prior to the procedure. We will record the time, in seconds, when patients lose their consciousness and corneal reflex. Levels of postoperative pain in children through Children and Infants Postoperative Pain Scale (CHIPPS). [ Time Frame: 1 hour ] After the procedure, all patients will be observed for changes in the Children and Infants Postoperative Pain Scale (CHIPPS) scores. Score changes will be assessed

2018 Clinical Trials

150. Serum Neurofilament Light Chain for Prognosis of Outcome After Cardiac Arrest. Full Text available with Trip Pro

performance than the other biochemical serum markers (ie, tau, neuron-specific enolase, and S100). At comparable specificities, serum NFL levels had greater sensitivity for poor outcome compared with routine electroencephalogram, somatosensory-evoked potentials, head computed tomography, and both pupillary and corneal reflexes (ranging from 29.2% to 49.0% greater for serum NFL level).Findings from this study suggest that the serum NFL level is a highly predictive marker of long-term poor neurologic

2018 JAMA neurology Controlled trial quality: uncertain

151. Universal ocular screening of 481 infants using wide-field digital imaging system. Full Text available with Trip Pro

assessment, eye position examination, external eye check, pupillary light reflex, red reflex examination, anterior and posterior ocular segments were examined using flashlight, ophthalmoscope, and wide-field digital imaging system.A total of 481 infants at 45.1 ± 6.1 days after birth were enrolled in the study. 198 infants had abnormal findings (41.2%). Retinal white spots and retinal white areas were the most common findings (42.9% of abnormalities and 17.7% of all infants screened). The second major (...) finding was retinal hemorrhage (16.2% of abnormalities and 6.7% of all infants screened). Other abnormal findings include retinal pigmentation, concomitant exotropia, neonatal dacryocystitis, retinopathy of prematurity, 'albinism-like fundus', congenital nasolacrimal duct obstruction, familial exudative vitreoretinopathy, immature retina, corneal dermoid tumor, large physiologic cupping of optic disc, congenital persistent pupillary membrane, entropion trichiasis, subconjunctival hemorrhage

2018 BMC Ophthalmology

152. Functional and aesthetic outcomes of eyelid skin grafting in facial nerve palsy. (Abstract)

Functional and aesthetic outcomes of eyelid skin grafting in facial nerve palsy. To report the functional and aesthetic outcomes of eyelid full-thickness skin grafting (FTSG) in patients with facial nerve palsy (FNP).This is a retrospective, non-comparative, single-centre review of all patients with FNP who underwent FTSG over an 8-year period. Functional outcomes were collected through case notes review: CADS (cornea, static asymmetry and dynamic and synkinesis) score facial nerve grading (...) and lagophthalmos on blink, gentle and forced closure. Marginal reflex distance (MRD1 and MRD2) was calculated on standardised photographs. The aesthetic outcomes were assessed objectively by two blinded independent assessors who assessed standardised photographs based on a mutually agreed grading scale. Both functional and aesthetic outcomes were measured preoperatively, and at early (1-3 months), intermediate (3-6 months) and late (>9 months) postoperative periods.A total of 28 eyelid FTSGs were performed

2018 British Journal of Ophthalmology

153. M7824 in Consensus Molecular Subtype 4, Treatment-Refractory Metastatic Colorectal Cancer

transplantation, but with the exception of transplants that do not require immunosuppression (e.g., corneal transplant, hair transplant). Significant acute or chronic infections including, among others: a) Known history of testing positive test for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome; b) HBV or HCV infection (HBV surface antigen positive and HBV core antibody positive with reflex to positive HBV DNA or HBV core antibody positive alone with reflex to positive HBV DNA (...) or positive HCV antibody with reflex to positive HCV RNA); c) Subjects with active tuberculosis (history of exposure or history of positive tuberculosis test plus presence of clinical symptoms, physical or radiographic findings). Active autoimmune disease that might deteriorate when receiving an immunostimulatory agent: a) Subjects with type I diabetes, vitiligo, alopecia, psoriasis, hypo- or hyperthyroid disease not requiring immunosuppressive treatment are eligible; b) Subjects requiring hormone

2018 Clinical Trials

154. Easy Stretch Toolkit: A Pilot Study

] function of cranial nerve III and IV as measured by following a finger for letter "H" Screening of cranial nerve function for CN III and IV [ Time Frame: completed at week 8 ] function of cranial nerve III and IV as measured by following a finger for letter "H" Screening of cranial nerve function for CN V [ Time Frame: completed at week 1 ] function of cranial nerve V as measured by corneal reflex test, clenching the teeth, among other actions Screening of cranial nerve function for CN V [ Time Frame (...) : completed at week 8 ] function of cranial nerve V as measured by corneal reflex test, clenching the teeth, among other actions Screening of cranial nerve function for CN VII [ Time Frame: completed at week 1 ] functional of cranial nerve VII as measured by closing the eyes, creasing the forehead, puffing out the cheeks, among other actions Screening of cranial nerve function for CN VII [ Time Frame: completed at week 8 ] functional of cranial nerve VII as measured by closing the eyes, creasing

2018 Clinical Trials

155. Effect of Exercise and Surgical Weight Loss on Polyneuropathy

in Intraepidermal Nerve Fiber Density (IENFD) at distal leg. [ Time Frame: Baseline, 3 months, 12 months and 24 months ] As assessed by 3mm skin biopsies. Linear mixed effects regression modeling will account for multiple time points of the same measure. Corneal Confocal Microscopy (CCM) [ Time Frame: Baseline, 3 month, 12 months and 24 months ] 24-2 Frequency Doubling Technology (FDT) [ Time Frame: Baseline, 3 month, 12 months and 24 months ] Retinal Fundus Photography [ Time Frame: Baseline, 3 month, 12 (...) of probable neuropathy [ Time Frame: 24 months ] Toronto definition of probable neuropathy-2 out of 3 of abnormal sensory examination, reflexes, and symptoms. Michigan Neuropathy Screening Instrument (MNSI) [ Time Frame: Baseline, 3 month, 12 months and 24 months ] Utah Early Neuropathy Score [ Time Frame: Baseline, 3 month, 12 months and 24 months ] Scale 0-48, higher is more severe polyneuropathy Modified Toronto Neuropathy Score (mTNS) [ Time Frame: Baseline, 3 month, 12 months and 24 months ] Range 0

2018 Clinical Trials

156. The Use of 3D Printing in Orbital Fractures

groups are recorded Number of subjects with a difference of more than 2 mm between the two orbits between the treatment and control groups [ Time Frame: 1 week, 3 weeks, and 6 weeks postoperatively. ] A difference of more than 2 mm between the two orbits is diagnostic for enophthalmos. Enophthalmos is assessed by clinical examination using a Hertel exophthalmometer. The measurement is taken from the lateral orbital rim to the corneal apex. The normal range is 12-21 mm. Upper normal limit for people (...) incarceration and a positive forced duction test. Immediate correction in a symptomatic patient with orbital floor ( trapdoor) fracture that has elicited the oculocardiac reflex. At least 18 years of age. Unilateral orbital floor fracture. No history of orbital trauma. Healthy contralateral orbit. Underwent orbital reconstruction. Admitted to GMH. Returned for the 6-week follow-up. Exclusion Criteria: Refuse study enrollment. Are younger than 18 years. Pregnant women. Prisoner Unable to obtain consent

2018 Clinical Trials

157. The Comparison of 50% AS Versus PFAT+ 0.05 % COE in Severe Dry Eye Syndrome

with or without preservatives) had low TBUT (< 5 s) (5μL of fluorescein sodium 2% eye drops was used) low Schirmer's test I score without topical anesthesia ( basic+reflex secretion), positive corneal and conjunctival fluorescein staining (≥grade 1 according to the OXFORD Scale) (3) and an OSDI score > 40 OSDI was a reliable and valid test for quantifying the severity of dry eye symptoms Exclusion Criteria: active ocular infection or any other inflammation not associated with dry eye a severe associated (...) : Layout table for MeSH terms Syndrome Keratoconjunctivitis Sicca Dry Eye Syndromes Disease Pathologic Processes Keratoconjunctivitis Conjunctivitis Conjunctival Diseases Eye Diseases Keratitis Corneal Diseases Lacrimal Apparatus Diseases Cyclosporins Cyclosporine Ophthalmic Solutions Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Immunosuppressive Agents Immunologic Factors Physiological Effects of Drugs Antifungal Agents Anti-Infective Agents Dermatologic Agents Antirheumatic Agents

2018 Clinical Trials

158. Cerebral Malaria in a Patient with HIV, Hepatitis B, and Hepatitis C Full Text available with Trip Pro

Cerebral Malaria in a Patient with HIV, Hepatitis B, and Hepatitis C Cerebral malaria is one of the most common causes of non-traumatic encephalopathy. A 25-year-old man who is a known intravenous and oral drug abuser presented to our clinic with fever and sore throat for two days prior and an altered level of consciousness for one day. On examination, the patient was icteric, and his Glasgow coma scale score on arrival was 10/15; he had dilated pupils reactive to light and a positive corneal (...) reflex. All cranial nerves were intact; however, signs of meningeal irritation were positive. Motor examination showed an increased tone and rigidity in all limbs, patellar reflex was 3+, plantars were down-going, and clonus was negative. A fundoscopic examination was unremarkable. Additional investigations revealed he was positive for Plasmodium falciparum, HIV, hepatitis B, and hepatitis C. In addition, a test of his cerebrospinal fluid revealed evidence of cerebral malaria. We initiated artemether

2018 Cureus

159. Dry Eye After LASIK. Full Text available with Trip Pro

suggested that the loss of corneal innervation caused by flap-making is the major cause, affecting the corneal-lacrimal gland, corneal-blinking, and blinking-meibomian gland reflexes, resulting in decreased aqueous and lipid tear secretion and mucin expression. A new type of corneal refractive surgery, SMILE, which has less impact on corneal nerves, induces less postoperative dry eye, supporting the association between corneal denervation and postoperative dry eye. As LASIK enhancement by flap-lifting (...) Dry Eye After LASIK. Post-LASIK dry eye is the most common postoperative dry eye after ophthalmic surgeries. The clinical signs of post-LASIK dry eye include positive vital staining of the ocular surface, decreased tear breakup time and Schirmer test values, reduced corneal sensitivity, and decreased functional visual acuity. The symptoms and signs usually last for about 1 month after LASIK. A small number of patients continue to experience symptoms more than 1 year postoperatively. It has been

2018 Investigative Ophthalmology & Visual Science

160. Measurement of Total Retinal Blood Flow and Oxygen Extraction in Patients With Diabetes and Healthy Subjects

in parallel. The system operates with an equivalent A-scan rate of 25 kHz and allows real time imaging of the color encoded Doppler information together with the tissue morphology at a rate of 2-4 tomograms (40 x 512 pixel) per second. Despite the high detection speed we achieve a system sensitivity of 86dB using a beam power of 500μW at the cornea. The fundus camera allows simultaneous view for selection of the region of interest. We observe bi-directional blood flow and pulsatility of blood velocity (...) ) It does not need reference arm scanning and records one full depth and Doppler profile in parallel. The system operates with an equivalent A-scan rate of 25 kHz and allows real time imaging of the color encoded Doppler information together with the tissue morphology at a rate of 2-4 tomograms (40 x 512 pixel) per second. Despite the high detection speed we achieve a system sensitivity of 86dB using a beam power of 500μW at the cornea. The fundus camera allows simultaneous view for selection

2018 Clinical Trials

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