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Corneal Reflex

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141. A Study to Evaluate the Raindrop Near Vision Inlay Under Flap or Within Pocket

with high pressures during suction application. 1.1.15 Patients with known history of steroid-responsive intraocular pressure increases, glaucoma, preoperative IOP > 21 mm Hg, or are otherwise suspected of having glaucoma. 1.1.16 Patients with amblyopia or strabismus or those who are at risk for developing strabismus postoperatively as determined by corneal light reflex and cover-uncover testing. 1.1.17 Patients with diabetic retinopathy, collagen, vascular, diagnosed autoimmune disease (e.g., lupus (...) : December 18, 2017 See Sponsor: Whitten Laser Eye Information provided by (Responsible Party): Whitten Laser Eye Study Details Study Description Go to Brief Summary: The objective of this study is to evaluate the Raindrop® Near Vision Inlay for the improvement of near vision in presbyopes implanted under a corneal flap or within a small-incision pocket. Condition or disease Intervention/treatment Phase Presbyopia Device: Raindrop Near Vision Inlay Phase 4 Detailed Description: Patients must require

2017 Clinical Trials

142. Epidermoid cysts of the cavernous sinus: clinical features, surgical outcomes, and literature review. (Full text)

with CS epidermoid cysts that had been surgically treated at the authors' hospital between 2001 and 2016. The patients' medical records, imaging data, and follow-up outcomes were retrospectively analyzed. The related literature from the past 40 years (18 articles, 20 patients) was also evaluated.The most common chief complaints were facial numbness or hypesthesia (64.5%), absent corneal reflex (45.2%), and abducens or oculomotor nerve deficit (35.5%). On MRI, 51.6% of the epidermoid cysts showed low

2017 Journal of Neurosurgery PubMed

143. External validation of prediction models for time to death in potential donors after circulatory death. (PubMed)

used the data of 92 potential cDCD donors. Multivariable regression analysis demonstrated that absent cough-, corneal reflex, lower morphine dosage, and midazolam use were significantly associated with death within 60 minutes (area under the curve [AUC] 0.89; 95% confidenence interval [CI] 0.87-0.91). External validation of the logistic regression models of de Groot et al (AUC 0.86; 95% CI 0.77-0.95), Wind et al (AUC 0.62; 95% CI 0.49-0.76), Davila et al (AUC 0.80; 95% CI 0.708-0.901) and the Cox

2017 American Journal of Transplantation

144. A prospective multicentre randomized placebo-controlled superiority trial in patients with suspected bacterial endophthalmitis after cataract surgery on the adjuvant use of intravitreal dexamethasone to intravitreal antibiotics. (PubMed)

, corneal oedema, the absence of a red fundus reflex on presentation, LP on presentation and culture of virulent pathogens from biopsy were statistically significantly associated with an unfavourable visual outcome.Intravitreal dexamethasone without preservatives as an adjuvant to intravitreal antibiotics does not improve visual acuity (VA) in patients treated for suspected bacterial endophthalmitis after cataract surgery.© 2017 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley

2017 Acta ophthalmologica

145. An Anti-VEGF-B Antibody Fragment Induces Regression of Pre-Existing Blood Vessels in the Rat Cornea. (Full text)

, compared to results in untreated controls). Cleaved caspase-3 was identified in vascular endothelial cells of anti-VEGF-B scFv-treated corneas. In scFv-treated rats, corneal endothelial cell function was maintained to 12 weeks after treatment and a normal blink reflex was present.The anti-VEGF-B scFv significantly regressed established but not developing corneal blood vessels in rats. (...) An Anti-VEGF-B Antibody Fragment Induces Regression of Pre-Existing Blood Vessels in the Rat Cornea. We tested the ability of an antibody fragment with specificity for vascular endothelial growth factor-B (VEGF-B) to regress nascent and established corneal blood vessels in the rat.A single chain variable antibody fragment (scFv) with specificity for VEGF-B was engineered from the 2H10 hybridoma. Binding to rat, mouse, and human VEGF-B was confirmed by surface plasmon resonance. Activity

2017 Investigative Ophthalmology & Visual Science PubMed

146. Quantification of rat supraglottic laryngeal sensation threshold. (PubMed)

, and 3) determine the ideal depth of anesthesia.Animal study.Rats were induced with ketamine/xylazine. The level of anesthesia was monitored by spontaneous glottic closure and corneal reflex testing. Air puffs were delivered to the epiglottis, arytenoid, and piriform sinus at varied pressures with pulse time kept constant. Sensation thresholds were determined by direct visualization of the larynx using a binocular microscope. Topical lidocaine was then applied to the larynx and ST was determined (...) . Trials were repeated in a small subset of animals.Twenty-six trials were performed in 14 rats. Mean STs were 39 ± 9.7 mm Hg at the epiglottis, 48.8 ± 10.5 at the arytenoid, and not detectable at the pyriform sinus. Repeated trials demonstrated consistent results. Lidocaine effectively ablated the LAR in each trial. The LAR was difficult to induce while corneal reflex was absent and was difficult to distinguish from spontaneous glottic closures while under lighter sedation.Air pulse stimulation

2017 Laryngoscope

147. Development of a Chromatic Pupillography Protocol for the First Gene Therapy Trial in Patients With CNGA3-Linked Achromatopsia. (Full text)

the pupillary light reflex parameters and to create the final protocol. In the individual protocols, various stimulus parameters (i.e., intensity, duration, wavelength, adaptation states) were applied to evaluate the impact of these stimuli on the pupillary response in untreated ACHM patients.In the light-adapted conditions, CNGA3-ACHM patients showed significantly reduced maximal amplitudes compared with the control group when using a 1-second high intensity (28-lux corneal illumination) blue or red (...) stimulus (P < 0.005). In the dark-adapted conditions, CNGA3-ACHM patients unexpectedly revealed significantly increased maximal amplitudes when stimulating with red (1 second) or blue (4 ms and 1 second) stimuli of low intensity (0.01-lux corneal illumination; P < 0.05). Pupil responses of CNGA3-ACHM patients after high intensity (28 lux) red and blue 1-second stimuli were within the normal range.Chromatic pupillography demonstrated significant reduced pupil responses to stimuli addressing primarily

2017 Investigative Ophthalmology & Visual Science PubMed

148. Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy. (Full text)

Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy. Impaired rate-dependent depression (RDD) of the Hoffman reflex is associated with reduced dorsal spinal cord potassium chloride cotransporter expression and impaired spinal γ-aminobutyric acid type A receptor function, indicative of spinal inhibitory dysfunction. We have investigated the pathogenesis of impaired RDD in diabetic rodents exhibiting features of painful neuropathy and the translational potential (...) of this marker of spinal inhibitory dysfunction in human painful diabetic neuropathy. Impaired RDD and allodynia were present in type 1 and type 2 diabetic rats but not in rats with type 1 diabetes receiving insulin supplementation that did not restore normoglycemia. Impaired RDD in diabetic rats was rapidly normalized by spinal delivery of duloxetine acting via 5-hydroxytryptamine type 2A receptors and temporally coincident with the alleviation of allodynia. Deficits in RDD and corneal nerve density were

2017 Diabetes PubMed

149. Small Incision Lenticule Extraction (SMILE) for Hyperopia: Optical Zone Centration. (PubMed)

) and astigmatism up to 6.00 D. For SMILE, the optical zone was between 6.3 and 6.7 mm, with a 2-mm transition zone. Two LASIK control groups (6.5- and 7-mm optical zone) were generated matched for spherical equivalent treated. In SMILE, the corneal vertex of the coaxially fixating eye was aligned with the vertex of the curved contact glass. In LASIK, the treatment was centered on the coaxially sighted corneal light reflex (first Purkinje image) with the contralateral eye (Seiler method). A tangential (...) (instantaneous) curvature preoperative to 3 months postoperative difference map was generated for each eye. A fixed grid and set of concentric circles were superimposed on the difference map to measure the offset between the optical zone center and corneal vertex (0,0), and vector analysis was used for comparative analysis.Mean attempted spherical equivalent was +5.61 ± 0.96 D (range: +3.20 to +6.50 D) and mean cylinder was -0.96 ± 0.62 D (range: 0.00 to -2.75 D) in the SMILE group. Mean age was 29 ± 7 years

2017 Journal of Refractive Surgery

150. Electroencephalography Predicts Poor and Good Outcomes After Cardiac Arrest: A Two-Center Study. (PubMed)

than 70% positive predictive value for good outcome; reactivity (80.4%; 95% CI, 75.9-84.4%) and motor response (80.1%; 95% CI, 75.6-84.1%) had highest accuracy. Early benign electroencephalography heralded good outcome in 86.2% (95% CI, 79.8-91.1%). False positive rates for mortality were less than 5% for epileptiform or nonreactive early electroencephalography, nonreactive late electroencephalography, absent somatosensory-evoked potential, absent pupillary or corneal reflexes, presence

2017 Critical Care Medicine

151. Outcome after Hunt and Hess Grade V subarachnoid hemorrhage: a comparison of pre-coiling era (1980-1995) versus post-ISAT era (2005-2014). (Full text)

treatment resulted in a significant improvement in survival rate (NNT = 2) and favorable outcome (NNT = 3 for mRS score of 0-3) for comatose patients with Hunt and Hess Grade V SAH compared with the earlier period. Independent predictors for favorable outcome were younger age and bilateral intact corneal reflexes. Despite a high rate of cerebral infarction (65%) in the current period, 29.5% of the patients who received treatment for their aneurysms during the current era (2005-2014) had a favorable

2017 Journal of Neurosurgery PubMed

152. A physician’s first code. See how it turned out.

stillness is serene, otherworldly. Impossible for a living being to achieve. The few remaining people in the room use hushed voices. The room feels sacred, somehow. I look at the man again. I think of Homer’s line from the Odyssey: “Upon his eyes gathered the mist of death.” I perform the death exam. I check his eyelids and see no corneal reflex. Feel no pulse. Hear no breath sounds. It’s done. I exit the room. A few feet from the door, a young black woman in cheery pink scrubs, is curled up in a ball

2017 KevinMD blog

153. Effects of Two Tear Substitutes in Patients With Dry Eye Syndrome

is 1-2 Exclusion Criteria: Any corneal,conjunctival, or eyelid abnormalities; conjunctivitis; current ocular infection; photophobia that may cause reflex tearing or difficulty in evaluating the patien 's lipid layer; Known allergic sensitivity to any of the ingredients in Liposic or Tears Naturale Forte Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information (...) of the participant recieved Tears Naturale Forte Other Name: DEXTRAN/HYPROMELLOSE/GLYCERIN Outcome Measures Go to Primary Outcome Measures : scale of Schirmer I test [ Time Frame: up to 3 months after tear substitutes apply ] scale of corneal fluorescein staining [ Time Frame: up to 3 months after tear substitutes apply ] scale of noninvasive tear breakup time [ Time Frame: up to 3 months after tear substitutes apply ] scale of tear meniscus height [ Time Frame: up to 3 months after tear substitutes apply

2017 Clinical Trials

154. NMES to Improve Eyelid Functions in Cranial Nerve (CN) III and VII Palsy

additional measures of eye and corneal health. Condition or disease Intervention/treatment Phase Blepharoptosis Lagophthalmos Device: Neuromuscular electrical stimulation Device: Sham neuromuscular electrical stimulation Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 60 participants Allocation: Randomized Intervention Model: Parallel Assignment Intervention Model Description: Active treatment vs. Sham control (...) for eyelid function for 5 consecutive days just as in the experimental group, However participants do not receive the electrical stimulation. Due to the low intensity of the stimulation all participants regardless of group allocation are told they may or may not feel the electrical stimulation. Outcome Measures Go to Primary Outcome Measures : Marginal reflex distance-1 (MRD-1) [ Time Frame: Within 1 week of last treatment session. ] Measure of eyelid function for participants with CN III or CN VII palsy

2017 Clinical Trials

155. Comparison Between Different Surgical Approaches for the Treatment of INVOLUTIONAL PTOSIS

or mullerectomy Outcome Measures Go to Primary Outcome Measures : MRD1 [ Time Frame: 6 months ] Distance in millimeters between corneal light reflex and upper eyelid margin surgery duration [ Time Frame: 3 hours ] Time from first incision to last suture (in minutes) Levator function [ Time Frame: 6 months ] change (in millimeters) in upper eyelid position from downgaze to maximal upgaze Secondary Outcome Measures : Need for additional eyelid surgery [ Time Frame: 6 months ] Any need for oculoplastic

2017 Clinical Trials

156. Congenital Cavitary Optic Disc Anomaly and Axenfeld’s Anomaly in Wolf-Hirschhorn Syndrome: A Case Report and Review of the Literature (Full text)

and Xp22.33-p22.2. Systemic findings included "Greek warrior helmet" facies, hypotonia, cleft palate, neonatal tooth eruption, talipes equinovarus, bilateral clinodactyly, clitoromegaly, partial agenesis of the corpus callosum, bilateral renal hypoplasia, and two atrial septal defects. Ocular findings included normal intraocular pressures and corneal diameters, large-angle exotropia, downward slanting of the palpebral fissures, absent eyelid creases, upper and lower eyelid retraction with shortage (...) of the anterior eyelid lamellae, euryblepharon, lagophthalmos with poor Bell's reflex and exposure keratopathy, hypertelorism, Axenfeld's anomaly, megalopapillae, and cavitary optic disc anomaly.We describe the ocular phenotype of a patient with Wolf-Hirschhorn syndrome, including the rare descriptions and photographs of Axenfeld's anomaly, megalopapilla, and cavitary optic disc anomaly in this condition.

2017 Ophthalmic genetics PubMed

157. Effect of Allopurinol for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome

or hyperexcitability) Severe muscular hypotonia or hypertonia, Absent or insufficient spontaneous respiration (e.g., gasping only) with need for respiratory support at 10 min postnatally Abnormal primitive reflexes (absent suck or gag or corneal or Moro reflex) or abnormal movements (e.g., potential clinical correlates of seizure activity) Exclusion criteria gestational age below 36 weeks birth weight below 2500 g postnatal age >30min at the end of screening phase severe congenital malformation or syndrome

2017 Clinical Trials

158. Oral Flurbiprofen Spray for Mucosal Graft Harvesting at the Palatal Area

at the site of affected area, topical NSAIDs have been suggested to use. Topical flurbiprofen was reported to decrease corneal sensitivity, to effect symptomatic relief of sore throat and to reduce acute post-operative pain after oral surgical procedures in previous studies. An oral spray formulation containing 0.075 g of flurbiprofen per 30 ml spray has been developed and frequently use for the inflammatory affections of the oral cavity, pharynx and larynx. The hypotheses for this study were (...) on the experimental sites before, no smoking, no pregnancy or lactation. Exclusion Criteria: hypersensitivity to flurbiprofen, history of allergy to NSAIDs, having coagulation disorders, presence of gagging reflex. Contacts and Locations Go to No Contacts or Locations Provided More Information Go to Layout table for additonal information Responsible Party: Sıla Çağrı İşler, PhD, Gazi University Identifier: Other Study ID Numbers: 36290600/66 First Posted: May 24, 2017 Last Update Posted: May 24

2017 Clinical Trials

159. Is Anesthetic Loss of Consciousness a Top Down or Bottom up Phenomenon. What Does the Neurologic Examination Say?.

ke0 1,21 min-1 using a calculated target of 5.4 ug/ml (loss of counsciousness EC95) and slow induction (GL) 10 mg/kg/h with calculated effect site concentrations (CeCALC) same PK model. The same neurologist, blind to the correspondent group, evaluated all the patients every 30 sec using the coma FOUR scale until loss of counsciousness (LOC), defined as a FOUR (E0 no eyes opening response and /or M0 no motor response). At LOC the existance of brainstem reflex was evaluated (B no pupil and corneal (...) reflex), respiratory pattern (R apnoea), CeCALC and patient state index (PSI) SEDline™ was recorded during all the examination. After LOC in both groups we maintain in GR the initial target (5.3 ug/ml) and the LOC CeCALC during 10 min without intervention, except respiratory support if it was required. Frontal EEG 4 channel and spectrogram from SEDline monitor was extracted for each case and posterior analysis. Fisher exact test was used to describe primary outcome and difference between B and R

2017 Clinical Trials

160. A Prospective Study to Evaluate the Raindrop Near Vision Inlay With Mitomycin C

suspected of having glaucoma. Patients with amblyopia or strabismus or those who are at risk for developing strabismus postoperatively as determined by corneal light reflex and cover-uncover testing. Patients with diabetic retinopathy, collagen, vascular, diagnosed autoimmune disease (e.g., lupus, rheumatoid arthritis, fibromylagia), immunodeficiency (e.g., HIV), connective tissue disease, or clinically significant atopic syndrome such as allergies or asthma. Patients on chronic systemic corticosteroid (...) Device: Raindrop Near Vision Inlay Phase 4 Detailed Description: The surgical procedure includes a low dose, short duration MMC treatment on the exposed stromal bed of the non-dominant eye, before the unilateral implantation of the corneal inlay. This treatment is at a concentration of 0.2 mg/mL (0.02%) applied for 10 to 30 seconds on the stromal bed as well as the stromal side of the corneal flap or pocket. In the third month after surgical procedure, one-drop a day of low dose steroid

2017 Clinical Trials

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