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Corneal Reflex

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102. Post-Resuscitation Therapy in Adult Advanced Life Support

that multiple modalities of testing (clinical exam, neurophysiological measures, imaging, or blood markers) be used to estimate prognosis instead of relying on single tests or findings. 25. ANZCOR recommends using bilaterally absent pupillary light reflexes (PLRs) or the combined absence of both pupillary and corneal reflexes at least 72 hours after ROSC to predict poor outcome in patients who are comatose after resuscitation from cardiac arrest and who are treated with TTM. 26. ANZCOR suggests against (...) of clinical criteria alone before 72 hours after ROSC to estimate prognosis. 38. ANZCOR suggests that multiple modalities of testing (clinical exam, neurophysiological measures, imaging, or blood markers) be used to estimate prognosis instead of relying on single tests or findings. 39. ANZCOR recommends using the absence of PLR (or the combined absence of both pupillary and corneal reflexes) at 72 hours or greater from ROSC to predict poor outcome in patients who are comatose after resuscitation from

2016 Australian Resuscitation Council

103. Newborn Nursing Care Pathway

history) Assess mother’s/ family/ supports understanding of newborn physiology and capacity to identify variances that may require further assessments Refer to: • Skin Norm and Normal Variations • Outer canthus aligned with upper ear • Dark or slate blue color • Blink reflex present • Edematous lids • Sclera clear • No tears • Pupils equal and reactive to light • May see subconjunctival hemorrhage • Administer eye prophylaxis (after completion of initial feeding or by 1 hour after birth) 20 promotes (...) months Parent education/ Anticipatory Guidance • Parent Education • Refer to >12 – 72 hr • No tears- tear ducts patent ~ 5 – 7 months Physiological Health: eyes Refer to: Healthy Families BC Website – www.healthyfamiliesbc.ca/parenting11 Newborn Guideline 13: Newborn Nursing Care Pathway Physiological Assessment 0 – 12 hours Period of Stability (POS) >12 – 24 hours >24 – 72 hours >72 hours – 7 days and beyond eyeS (Continued) Variance • Hazy, dull cornea • Pupils unequal, dilated constricted

2015 British Columbia Perinatal Health Program

105. Legal and Ethical Issues related to Resuscitation

, severe cerebral disability). The earliest time to prognosticate an unfavourable neurological outcome is 72 hours after ROSC, but longer if sedative or paralytic drugs confound the situation. 9 Among predictive factors are the clinical observations of persistent coma, bilateral absent pupillary or corneal reflexes, absent motor and extensor response to pain, presence of myoclonus, absent N20 wave in somato-sensory evoked potentials, high serum values of neurological biomarkers, a marked reduction

2015 Australian Resuscitation Council

108. Anoro (umeclidinium bromide / vilanterol trifenatate)

At 36, 612 and 34399 mcg/kg: Decrease in motor activity at time points up to 9 hours following start of exposure. At 34399 mcg/kg: Decreased body temperature (up to 1.6°C) at 1.25 hours following start of exposure. Rat Conscious male Sprague Dawley rats were intravenously administered with single dose of vehicle or GW642444H. Animals were observed for peripheral and central nervous systems activities (e.g. motor activity, behaviour, co-ordination, somatic sensory/motor reflex responses and automatic

2014 European Medicines Agency - EPARs

109. Laventair - umeclidinium bromide / vilanterol

(e.g. motor activity, behaviour, co-ordination, somatic sensory/motor reflex responses and automatic responses such as piloerection, pupil size, lachrymation, salivation, overt cardiovascular and gastrointestinal effects) and potential effects on body temperature. Assessment report EMA/CHMP/163509/2014 Page 28/309 In other study also performed in conscious male Sprague Dawley CD rats, GW642444M was administered as a single dose via snout-only inhalation. Animals were subjected to neurobehavioural

2014 European Medicines Agency - EPARs

110. Harvoni - sofosbuvir / ledipasvir

observations. No statistically significant findings were noted for forelimb grip strength, hindlimb grip strength, nociceptive reflex, or body temperature in animals given 10, 30, or 100 mg/kg. In the rat respiratory study animals given 10 or 30 mg/kg displayed statistically significant overall increases in covariate-adjusted mean minute volume compared with controls across the measured timepoints. The low magnitude of the effect and lack of statistically significant effect at 100 mg/kg suggested

2014 European Medicines Agency - EPARs

111. Evolocumab (Repatha)

by Background Therapy and Investigational Product Study 20110109 82 Table 12: Analysis of Percent Change from Baseline in Ultracentrifugation LDL-C at Week 52 by Background Therapy in Trial 20110109 (Full Analysis Set) 84 Table 13: Treatment Effects (EvoMab vs Placebo) of Week 12 and Week 52 in Trial 20110109 (Full Analysis Set) 86 Table 14: Treatment Differences in the Percent Change From Baseline at Week 52 Compared With Placebo Using UC LDL-C, Calculated LDL-C, or Reflexive LDL-C in Trial 20110109 (Full (...) ’ and HeFH. Of note, participants who were not on concomitant statin therapy included individuals at low CV risk that did not warrant any lipid-lowering therapy as well as individuals at increased CV risk who did need to be on lipid-lowering therapy but had not tolerated statins in the past. The integrated analyses from the four phase 3 12-week trials demonstrated statistically significant reductions in reflexive 2 LDL-C for both dosing regimens (evolocumab 140 mg Q2W and 420 mg QM dosing) (multiplicity

2014 FDA - Drug Approval Package

114. Vyndaqel (tafamidis meglumine)

thyroid stimulating hormone decreased; blood thyroid stimulating hormone increased; blood thyroid stimulating hormone; thyroid releasing hormone challenge test abnormal; and thyroid releasing hormone challenge test. 12) Events in the MedDRA SMQ “lacrimal disorders” and PTs: dry eye; lacrimation decreased; lacrimal disorder; keratomalacia; xerophthalmia; vitamin A deficiency; vitamin A deficiency related corneal disorder; vitamin A deficiency eye disorder; vitamin A deficiency related conjunctival (...) disorder; night blindness; corneal deposits; corneal leukoma; corneal lesion; corneal degeneration; and dry skin. 13 ) Events in the MedDRA SMQ “hyperglycaemia/new onset diabetes mellitus”, HLGT “diabetic complications”, and HLTs “hyperglycaemic conditions NEC”, “diabetes mellitus (incl subtypes)”, and “carbohydrate tolerance analyses (incl diabetes)” (excluding “decreased” PTs under the HLT “carbohydrate tolerance analyses (incl diabetes)”). 16 3.(ii) Summary of pharmacokinetic studies 3.(ii

2013 Pharmaceuticals and Medical Devices Agency, Japan

115. Prolonged analgesic response of cornea to topical resiniferatoxin, a potent TRPV1 agonist. Full Text available with Trip Pro

and consequently a target for pain control. Resiniferatoxin (RTX), a potent TRPV1 agonist, produces transient analgesia when injected peripherally by inactivating TRPV1-expressing nerve terminals through excessive calcium influx. The aim of the present study was to evaluate topical RTX as a corneal analgesic. In rat cornea, a single application of RTX dose dependently eliminated or reduced the capsaicin eye wipe response for 3-5 days, with normal nociceptive responses returning by 5-7 days. RTX alone produced (...) a brief but intense noxious response, similar to capsaicin, necessitating pretreatment of the cornea with a local anesthetic. Topical lidocaine, applied prior to RTX, blocks acute nociceptive responses to RTX without impairing the subsequent analgesic effect. Importantly, RTX analgesia (a) did not impair epithelial wound healing, (b) left the blink reflex intact and (c) occurred without detectable histological damage to the cornea. Immunohistochemistry showed that loss of CGRP immunoreactivity

2010 Pain

116. The effect of etomidate or propofol on brainstem function during anesthesia induction: a bispectral index-guided study. Full Text available with Trip Pro

The effect of etomidate or propofol on brainstem function during anesthesia induction: a bispectral index-guided study. To compare the effect of etomidate versus propofol infusion on hemodynamic profiles, spontaneous breathing, and corneal reflex during the induction of anesthesia.Adult patients (n=80) were randomized to receive etomidate (Group E, n=40) or propofol (Group P, n=40) infusion during anesthesia induction. Throughout induction, mean blood pressure and heart rate were monitored (...) . Time to loss of consciousness (LOC), bispectral index (BIS), existence of spontaneous breathing, and corneal reflex at LOC were recorded.Fewer changes in hemodynamic profile occurred in Group E compared with Group P during induction of anesthesia. The mean time to LOC was shorter with etomidate than propofol (129.5 s vs 189.5 s, P<0.0001). BIS was lower in Group E compared with Group P at LOC (46.3 vs 52.9, P=0.0141). More patients exhibited spontaneous breathing in Group E compared with Group P

2019 Drug design, development and therapy Controlled trial quality: uncertain

117. Decentration following femtosecond laser small incision lenticule extraction (SMILE) in eyes with high astigmatism and its impact on visual quality. Full Text available with Trip Pro

, China.. Patients with myopic astigmatism < 1.5D served as controls (low astigmatism group, LA). Decentration was measured using a Scheimpflug camera with a difference map of the tangential curvature at 12 months postoperatively. Also the associations between decentration from the coaxial sighted corneal light reflex (CSCLR) and the visual outcomes, correction efficacy of astigmatism, wavefront aberrations and objective scatter index (OSI) were analyzed.No significant differences were observed

2019 BMC Ophthalmology

118. Quantitative measurement of horizontal strabismus with digital photography. Full Text available with Trip Pro

to the light reflex (RD) and corneal diameter (CD). The RD/CD ratio of each gaze angle was recorded. To estimate the eyes' gaze angle, an equation to determine the best-fit line for the gaze angle data according to each RD/CD ratio was created. In a second clinical analysis, this equation was applied to photographs of real strabismus patients (n = 72), and the results were compared with measurements taken by a double-masked strabismus specialist. Separately, an equation was created to calculate the imaging (...) Quantitative measurement of horizontal strabismus with digital photography. To develop a method to calculate the gaze angle in photographs and to determine its validity and reliability in real strabismus patients.Photographs of eyes from 15 orthophoric subjects (n = 1,022) with known gaze angle and imaging distance were investigated with the help of a smartphone application developed by the authors. The application provided measurements of the distance from the geometrical center of the cornea

2019 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

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