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Corneal Reflex

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601. A Novel Mouse Model for Neurotrophic Keratopathy: Trigeminal Nerve Stereotactic Electrolysis through the Brain. Full Text available with Trip Pro

A Novel Mouse Model for Neurotrophic Keratopathy: Trigeminal Nerve Stereotactic Electrolysis through the Brain. To develop a mouse model of neurotrophic keratopathy by approaching the trigeminal nerve through the brain and to evaluate changes in corneal cell apoptosis and proliferation.Six- to 8-week-old male C57BL/6 mice underwent trigeminal stereotactic electrolysis (TSE) to destroy the ophthalmic branch of the trigeminal nerve. Clinical follow-up using biomicroscopy of the cornea (...) was performed at days 2, 4, 5, and 7. To confirm the effectiveness of the procedure, we examined the gross nerve pathology, blink reflex, and immunohistochemistry of the corneal nerves. TUNEL-positive apoptotic and Ki-67-positive proliferating corneal cells were evaluated to detect changes from the contralateral normal eye.TSE was confirmed by gross histology of the trigeminal nerve and was considered effective if the corneal blink reflex was completely abolished. TSE totally abolished the blink reflex

2010 Investigative Ophthalmology & Visual Science

602. Evaluation of Objective Perimetry Using Pupillometer

): Dr. Ygal Rotenstreich, Sheba Medical Center Study Details Study Description Go to Brief Summary: Objective perimetry can better monitor visual field defects in RP and Glaucoma patients than conventional subjective perimetry.The PLR ( Pupil Light Reflex ) of the short and long wave ratio should be significantly higher in areas of visual field defects in RP and Glaucoma patients. Condition or disease Retinitis Pigmentosa Glaucoma Visual Field Detailed Description: Pupil light reflex (...) with early glaucoma damage on HVF (nasal step ect. ), Glaucoma patients with advanced glaucoma damage on HVF (arcuate , tubular vision ) and RP patients (Early VF damage , ring scotoma ) . Refractive correction up to -3.5 D. Exclusion Criteria: Cloudy corneas. Surgical intraocular ophthalmic procedure within the past 30 days. Nonreactive pupils. Synechia of the iris to the lens after surgery or inflammation . Neovascularization. Iris coloboma. Sphincter damage due to ischemia or trauma (tears

2009 Clinical Trials

603. Determine the Effect of Intraocular Pressure (IOP), Optic Nerve Imaging, Venous Congestion in Volunteers Prone Position 5 Hours

optic nerve imaging, refractometry, ultrasound, corneal thickness pachymetry, measurement of proptosis, measurement of pupillary reflex, The volunteers do not receive anesthetic medications or intravenous fluids and will provide a baseline for comparision with patients enrolled in the prospective study. Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 10 participants Observational Model: Case-Crossover Time Perspective: Prospective Official Title

2009 Clinical Trials

604. Topical Cyclosporine vs. Placebo for Epiphora Associated With Docetaxel

; diagnosed with acne rosacea and currently on any systemic tetracycline antibiotic or any other prescribed treatment such as metronidazole, or have used any prescribed treatment for acne rosacea in the past; active ocular infection or inflammation in any eye; active ocular allergy in any eye; abnormal dilated fundus examination indicative of intraocular tumor presence; corneal disorder or abnormality that affects cornea sensitivity or normal spreading of the tear film in any eye; severe blepharitis (...) or obvious inflammation of the lid margin in any eye which, in the judgment of the investigator, may interfere with the interpretation of the study results; history of punctal occlusion, canalicular stenosis or nasolacrimal duct blockage. unable to cannulate the puncta (grade 3 on the Canalicular Stenosis Scale); unable to successfully irrigate the canaliculi; Schirmer's Test - Standard Test (with anesthesia) result of reflex tearing resulting from dry eye syndrome; history

2009 Clinical Trials

605. Photographic assessment of changes in torsional strabismus. (Abstract)

Photographic assessment of changes in torsional strabismus. The horizontal and vertical components of strabismus are measured routinely and relatively easily in the clinical setting using prism-and-cover and/or corneal light reflex tests. The third dimension of ocular alignment, ocular torsion, is more difficult to assess. Objective torsional deviation (cyclotropia) is evaluated qualitatively with fundus examination. For quantitative assessment, however, fundus photography is needed, which may

2009 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

606. Comparison of myopic LASIK centered on the coaxially sighted corneal light reflex or line of sight. Full Text available with Trip Pro

Comparison of myopic LASIK centered on the coaxially sighted corneal light reflex or line of sight. To compare refractive outcomes of myopic LASIK with centration on the coaxially sighted corneal light reflex (CSCLR) to centration on the center of the pupil (line of sight [LOS]).The NIDEK CXIII excimer laser was used to treat 268 eyes with centration on the CSCLR (CSCLR group) and 288 eyes with centration on the LOS (LOS group). For the CSCLR group, the laser ablation was delivered 80% closer

2009 Journal of Refractive Surgery

607. Relationship between Static Ocular Counterroll and Bielschowsky Head-tilt Phenomenon. Full Text available with Trip Pro

camera, static ocular counterrolling (s-OCR) was determined by measuring the inclination of a line connecting the two centroids of the characteristic iris pattern and corneal reflex. The BHP was measured with the alternate prism and cover test.The mean (SD) amplitude of s-OCR in paretic eyes based on the fit of the regression sine curve against the ipsilesional head tilt angle was significantly decreased compared with that for contralesional head tilt, 6.3 (3.5) degrees for ipsilesional and 11.3 (3.9

2009 Investigative Ophthalmology & Visual Science

608. Outcomes of hyperopic LASIK with the NIDEK NAVEX platform centered on the visual axis or line of sight. (Abstract)

were digitally transferred to the excimer laser system based on the positional relationship between the LOS and the coaxially sighted corneal light reflex. All eyes were treated with a 6.5-mm optical zone and 9.0-mm transition zone. Three-month postoperative outcomes were retrospectively analyzed.The preoperative manifest refraction spherical equivalent (MRSE) was +2.57+/-1.26 diopters (D) (range: 0.13 to 5.63 D) in the visual axis group and +2.46+/-1.32 D (range: 0.38 to 5.63 D) in the LOS group

2009 Journal of Refractive Surgery

609. examination of fundi

- the red numbers of most ophthalmoscopes - and at arm's length with the patient gazing into the distance - starting the examination in this manner prevents reflex pupil contraction which occurs if the patient attempts to accommodate. Rack the ophthalmoscope towards zero. Sequentially, with racking down, examine the: cornea for ulcers lens for opacities - cataracts may cause and prevent full examination of the fundus vitreous disc: this is found by following a large retinal vein back towards the disc

2010 GP Notebook

610. keratitis

, corneal oedema blood vessel dilatation is typically concentrated around the limbus - circumcorneal injection often, the conjunctiva is also inflamed - keratoconjunctivitis discharge is usually present and may be watery, mucoid or purulent; notably, it is absent in keratoconjunctivitis sicca pupil may be small due to reflexive miosis; photophobia is common fluorescein readily demonstrates any ulceration (an epithelial breach) Keratitis an cause significant loss of vision from (1): scarring astigmatism (...) keratitis keratitis - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search keratitis Keratitis is inflammation of the cornea. This may result from a variety of bacterial, viral or fungal infections, or may be non-infective, for example due to trauma or associated with an auto-immune disease. Inflammation of the cornea commonly presents as a painful red eye with reduced visual acuity due to cellular infiltration and later

2010 GP Notebook

611. cranial nerves

strength corneal reflex, if appropriate VII furrowing of brow on frowning, raising of eyebrows show teeth, smile, puff out cheeks screwing up of eyes facial movement VIII repeat number whispered into each ear Rinne's test Weber's test IX, X palatal movement, difficulty swallowing, gag reflex quality of speech: nasal guttural say "ee" XI sternocleidomastoid and trapezius bulk and strength XII tongue at rest and on movements to command, e.g. protrude say "la" and "ta"; quality of articulation Links

2010 GP Notebook

612. examination of the patient with dizziness

for : signs of palsies and sensorineural hearing loss this includes particularly funduscopy for papilloedema or optic atrophy (II) eye movements (III, IV, and VI) corneal reflex (V) facial movement (VII) tuning folk tests for hearing loss(VIII) special attention is paid to those that pass through the cerebellopontine angle - the fifth to the seventh. nystagmus common in acute virtigo (2) vertical nystagmus (1) is commonly seen in vestibular nuclear or cerebellar vermis lesions horizontal nystagmus

2010 GP Notebook

613. clinical examination of the dizzy patient

for : signs of palsies and sensorineural hearing loss this includes particularly funduscopy for papilloedema or optic atrophy (II) eye movements (III, IV, and VI) corneal reflex (V) facial movement (VII) tuning folk tests for hearing loss(VIII) special attention is paid to those that pass through the cerebellopontine angle - the fifth to the seventh. nystagmus common in acute virtigo (2) vertical nystagmus (1) is commonly seen in vestibular nuclear or cerebellar vermis lesions horizontal nystagmus

2010 GP Notebook

614. keratitis (eye)

and later, corneal oedema blood vessel dilatation is typically concentrated around the limbus - circumcorneal injection often, the conjunctiva is also inflamed - keratoconjunctivitis discharge is usually present and may be watery, mucoid or purulent; notably, it is absent in keratoconjunctivitis sicca pupil may be small due to reflexive miosis; photophobia is common fluorescein readily demonstrates any ulceration (an epithelial breach) Keratitis an cause significant loss of vision from (1): scarring (...) keratitis (eye) keratitis (eye) - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search keratitis (eye) Keratitis is inflammation of the cornea. This may result from a variety of bacterial, viral or fungal infections, or may be non-infective, for example due to trauma or associated with an auto-immune disease. Inflammation of the cornea commonly presents as a painful red eye with reduced visual acuity due to cellular infiltration

2010 GP Notebook

615. Biograstim (filgrastim)

parameters were examined: body position; restlessness; writhing; stereotypic behaviour; convulsions; twitches and tremors; grooming; ease of removal; gait; palpebral closure; piloerection; respiratory rate/pattern; locomotor activity level; defecation/urination; escape response; lacrimation; pupil size; salivation; diarrhoea; body tone; staub tail; cutaneous blood flow; corneal reflex; pinna reflex; tail pinch; auricular startle; righting reflex; positional passivity; vocalisation; and geotropism

2008 European Medicines Agency - EPARs

616. Implantable miniature telescope for macualar degeneration (Update)

(Williams et al 1998; Tolman et al 2005). Designed for patients with advanced dry and wet stage AMD, the IMT is a prosthetic telescope device measuring 4.4mm in length and weighing 46.1mg in an aqueous environment. The device is implanted behind the pupil in the posterior chamber of one eye during an outpatient surgical procedure that takes approximately 45 minutes. Once implanted, the IMT together with the cornea functions as a telephoto lens, providing three times magnification on the retina (...) of visual tasks. External telescopes are generally cumbersome and cosmetically unappealing, and the visual field they offer is severely restricted (5 to 10 degrees, compared to 36 degrees for the IMT). Patients can also experience nausea when using external 2 Update Implantable miniature telescope for macular degeneration: August 2007 telescopes because of the vestibular ocular reflex conflict caused by the need to scan the visual field using head movement rather than natural eye movement (Peli 2002

2007 Australia and New Zealand Horizon Scanning Network

617. Implantable Miniature Telescope for the treatment of age-related macular degeneration

, and an overall decrease in quality of life (Williams et al 1998; Tolman et al 2005). Designed for patients with advanced dry and wet stage AMD, the IMT is a prosthetic telescope device measuring 4.4mm in length and weighing 46.1mg in an aqueous environment. The device is implanted behind the pupil in the posterior chamber of one eye during an outpatient surgical procedure that takes approximately 45 minutes. Once implanted, the IMT together with the cornea functions as a telephoto lens, providing three times (...) inappropriate for a large number of visual tasks. External telescopes are generally cumbersome and cosmetically unappealing, and the visual field they offer is severely restricted (5 to 10 degrees, compared to 36 degrees for the IMT). Patients can also experience nausea when using external telescopes because of the vestibular ocular reflex conflict caused by the need to scan the visual field using head movement rather than natural eye movement (Peli 2002). A number of non-optical treatments for AMD have

2006 Australia and New Zealand Horizon Scanning Network

619. Prediction of outcome in comatose survivors after cardiopulmonary resuscitation

months. Results: The authors identified four class I studies, three class II studies, and five class III studies on clinical findings and circumstances. The indicators of poor outcome after CPR are absent pupillary light response or corneal reflexes, and extensor or no motor response to pain after 3 days of observation (level A), and myoclonus status epilepticus (level B). Prognosis cannot be based on circumstances of CPR (level B) or elevated body temperature (level C). The authors identified one (...) predicted poor outcome (level B). Ten class IV studies on brain monitoring and neuroimaging did not provide data to support or refute usefulness in prognostication (level U). Conclusion: Pupillary light response, corneal reflexes, motor responses to pain, myoclonus status epilepticus, serum neuron-specific enolase, and somatosensory evoked potential studies can reliably assist in accurately predicting poor outcome in comatose patients after cardiopulmonary resuscitation for cardiac arrest. Despite

2006 American Academy of Neurology

620. Ocular Emergencies

to the immediate environment preceding the injury. Small, sharp, high velocity objects, for example, resulting from hammering metal on metal, or through the use of a grinder, often lead to penetrating injuries. 1 An accident or fall may cause blunt trauma and present different issues. This knowledge is vital and will direct further testing. Observation of the patient can be performed with a bright light and pen torch. Particular care should be given to noticing the presence of foreign bodies, chemosis, corneal (...) haze and the presence of blood or pus in the anterior segment of the eye. 2 Fluorescein staining and examination under a blue light helps determine the extent of corneal injury. If full thickness corneal injury is present, aqueous humour may be seen to leak (Seidel test). This requires emergency referral. Pupil examination is a particularly useful objective assessment of the afferent and efferent visual pathways. 3 The presence of a pupillary defect is an important diagnostic sign. Pupil

2008 The Royal Australian College of General Practitioners

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