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Corneal Reflex

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601. Construct validity of a surgical simulator as a valid model for capsulorhexis training. (Abstract)

with the simulator. Each participant completed 4 trials on the capsulorhexis module.The 7 experienced surgeons achieved statistically significantly better total scores than the 16 medical students and residents on the easy level and the medium level of the capsulorhexis module (P = .004 and P = .000007, respectively). Experienced surgeons achieved significantly better scores in all parameters at the medium level, with better centering (P = .001), less corneal injury (P = .02), fewer spikes (P = .03), less time (...) operating without a red reflex (P = .0005), better roundness of the capsulorhexis (P = .003), and less time completing tasks (P = .008).The surgical simulator capsulorhexis module showed significant construct validity (P<.05).Published by Elsevier Inc.

2010 Journal of cataract and refractive surgery

602. Predictors of neurologic outcome in hypothermia after cardiac arrest. Full Text available with Trip Pro

, and electroencephalogram (EEG) results were recorded. EEG patterns were blindly dichotomized with malignant patterns consisting of burst-suppression, generalized suppression, status epilepticus, and nonreactivity. Outcome measure of in-hospital mortality was assessed.A total of 192 patients (103 hypothermic, 89 nonhypothermic) were studied. The absence of pupillary light responses, corneal reflexes, and an extensor or absent motor response at Day 3 after cardiac arrest remained accurate predictors of poor outcome (...) reflexes, motor response, and presence of myoclonus) at Day 3 after cardiac arrest remains an accurate predictor of outcome after therapeutic hypothermia. Sedative medications in both hypothermic and nonhypothermic patients may confound the clinical exam. NSE > 33 ng/ml has a high false-positive rate in patients treated with hypothermia and should be interpreted with caution.

2010 Annals of Neurology

603. Fixation-Free Assessment of the Hirschberg Ratio. Full Text available with Trip Pro

Fixation-Free Assessment of the Hirschberg Ratio. To describe a novel methodology by which to measure the Hirschberg ratio (HR) in infants. The methodology does not require fixation on specific points, and measurements are made while infants look naturally at a display.The HR is calculated automatically from measurements of the direction of the optical axis, the position of the pupil center, and corneal reflexes in video images from an advanced two-camera eye-tracking system. The performance

2010 Investigative Ophthalmology & Visual Science

604. Factors influencing time to death after withdrawal of life support in neurocritical patients. Full Text available with Trip Pro

. A total of 75 patients had cardiac arrest in <60 minutes; 57% were male and 52% were older than 66 years. Ischemic stroke (30%) and intraparenchymal hemorrhage (52%) were the most frequent diagnoses. Absent corneal (odds ratio [OR] = 4.24, 95% confidence interval [CI] 1.57-11.5, p = 0.005) and cough reflexes (OR = 4.46, 95% CI 1.93-10.3, p = 0.0005), extensor or absent motor response (OR = 2.83, 95% CI 1.01-7.91, p = 0.048), and an oxygenation index greater than 4.2 (OR = 3.36, 95% CI 1.33-8.5, p

2010 Neurology

605. A Novel Mouse Model for Neurotrophic Keratopathy: Trigeminal Nerve Stereotactic Electrolysis through the Brain. Full Text available with Trip Pro

A Novel Mouse Model for Neurotrophic Keratopathy: Trigeminal Nerve Stereotactic Electrolysis through the Brain. To develop a mouse model of neurotrophic keratopathy by approaching the trigeminal nerve through the brain and to evaluate changes in corneal cell apoptosis and proliferation.Six- to 8-week-old male C57BL/6 mice underwent trigeminal stereotactic electrolysis (TSE) to destroy the ophthalmic branch of the trigeminal nerve. Clinical follow-up using biomicroscopy of the cornea (...) was performed at days 2, 4, 5, and 7. To confirm the effectiveness of the procedure, we examined the gross nerve pathology, blink reflex, and immunohistochemistry of the corneal nerves. TUNEL-positive apoptotic and Ki-67-positive proliferating corneal cells were evaluated to detect changes from the contralateral normal eye.TSE was confirmed by gross histology of the trigeminal nerve and was considered effective if the corneal blink reflex was completely abolished. TSE totally abolished the blink reflex

2010 Investigative Ophthalmology & Visual Science

606. Evaluation of Objective Perimetry Using Pupillometer

): Dr. Ygal Rotenstreich, Sheba Medical Center Study Details Study Description Go to Brief Summary: Objective perimetry can better monitor visual field defects in RP and Glaucoma patients than conventional subjective perimetry.The PLR ( Pupil Light Reflex ) of the short and long wave ratio should be significantly higher in areas of visual field defects in RP and Glaucoma patients. Condition or disease Retinitis Pigmentosa Glaucoma Visual Field Detailed Description: Pupil light reflex (...) with early glaucoma damage on HVF (nasal step ect. ), Glaucoma patients with advanced glaucoma damage on HVF (arcuate , tubular vision ) and RP patients (Early VF damage , ring scotoma ) . Refractive correction up to -3.5 D. Exclusion Criteria: Cloudy corneas. Surgical intraocular ophthalmic procedure within the past 30 days. Nonreactive pupils. Synechia of the iris to the lens after surgery or inflammation . Neovascularization. Iris coloboma. Sphincter damage due to ischemia or trauma (tears

2009 Clinical Trials

607. Determine the Effect of Intraocular Pressure (IOP), Optic Nerve Imaging, Venous Congestion in Volunteers Prone Position 5 Hours

optic nerve imaging, refractometry, ultrasound, corneal thickness pachymetry, measurement of proptosis, measurement of pupillary reflex, The volunteers do not receive anesthetic medications or intravenous fluids and will provide a baseline for comparision with patients enrolled in the prospective study. Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 10 participants Observational Model: Case-Crossover Time Perspective: Prospective Official Title

2009 Clinical Trials

608. Topical Cyclosporine vs. Placebo for Epiphora Associated With Docetaxel

; diagnosed with acne rosacea and currently on any systemic tetracycline antibiotic or any other prescribed treatment such as metronidazole, or have used any prescribed treatment for acne rosacea in the past; active ocular infection or inflammation in any eye; active ocular allergy in any eye; abnormal dilated fundus examination indicative of intraocular tumor presence; corneal disorder or abnormality that affects cornea sensitivity or normal spreading of the tear film in any eye; severe blepharitis (...) or obvious inflammation of the lid margin in any eye which, in the judgment of the investigator, may interfere with the interpretation of the study results; history of punctal occlusion, canalicular stenosis or nasolacrimal duct blockage. unable to cannulate the puncta (grade 3 on the Canalicular Stenosis Scale); unable to successfully irrigate the canaliculi; Schirmer's Test - Standard Test (with anesthesia) result of reflex tearing resulting from dry eye syndrome; history

2009 Clinical Trials

609. Photographic assessment of changes in torsional strabismus. (Abstract)

Photographic assessment of changes in torsional strabismus. The horizontal and vertical components of strabismus are measured routinely and relatively easily in the clinical setting using prism-and-cover and/or corneal light reflex tests. The third dimension of ocular alignment, ocular torsion, is more difficult to assess. Objective torsional deviation (cyclotropia) is evaluated qualitatively with fundus examination. For quantitative assessment, however, fundus photography is needed, which may

2009 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

610. Comparison of myopic LASIK centered on the coaxially sighted corneal light reflex or line of sight. Full Text available with Trip Pro

Comparison of myopic LASIK centered on the coaxially sighted corneal light reflex or line of sight. To compare refractive outcomes of myopic LASIK with centration on the coaxially sighted corneal light reflex (CSCLR) to centration on the center of the pupil (line of sight [LOS]).The NIDEK CXIII excimer laser was used to treat 268 eyes with centration on the CSCLR (CSCLR group) and 288 eyes with centration on the LOS (LOS group). For the CSCLR group, the laser ablation was delivered 80% closer

2009 Journal of Refractive Surgery

611. Relationship between Static Ocular Counterroll and Bielschowsky Head-tilt Phenomenon. Full Text available with Trip Pro

camera, static ocular counterrolling (s-OCR) was determined by measuring the inclination of a line connecting the two centroids of the characteristic iris pattern and corneal reflex. The BHP was measured with the alternate prism and cover test.The mean (SD) amplitude of s-OCR in paretic eyes based on the fit of the regression sine curve against the ipsilesional head tilt angle was significantly decreased compared with that for contralesional head tilt, 6.3 (3.5) degrees for ipsilesional and 11.3 (3.9

2009 Investigative Ophthalmology & Visual Science

612. Outcomes of hyperopic LASIK with the NIDEK NAVEX platform centered on the visual axis or line of sight. (Abstract)

were digitally transferred to the excimer laser system based on the positional relationship between the LOS and the coaxially sighted corneal light reflex. All eyes were treated with a 6.5-mm optical zone and 9.0-mm transition zone. Three-month postoperative outcomes were retrospectively analyzed.The preoperative manifest refraction spherical equivalent (MRSE) was +2.57+/-1.26 diopters (D) (range: 0.13 to 5.63 D) in the visual axis group and +2.46+/-1.32 D (range: 0.38 to 5.63 D) in the LOS group

2009 Journal of Refractive Surgery

613. examination of fundi

- the red numbers of most ophthalmoscopes - and at arm's length with the patient gazing into the distance - starting the examination in this manner prevents reflex pupil contraction which occurs if the patient attempts to accommodate. Rack the ophthalmoscope towards zero. Sequentially, with racking down, examine the: cornea for ulcers lens for opacities - cataracts may cause and prevent full examination of the fundus vitreous disc: this is found by following a large retinal vein back towards the disc

2010 GP Notebook

614. keratitis

, corneal oedema blood vessel dilatation is typically concentrated around the limbus - circumcorneal injection often, the conjunctiva is also inflamed - keratoconjunctivitis discharge is usually present and may be watery, mucoid or purulent; notably, it is absent in keratoconjunctivitis sicca pupil may be small due to reflexive miosis; photophobia is common fluorescein readily demonstrates any ulceration (an epithelial breach) Keratitis an cause significant loss of vision from (1): scarring astigmatism (...) keratitis keratitis - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search keratitis Keratitis is inflammation of the cornea. This may result from a variety of bacterial, viral or fungal infections, or may be non-infective, for example due to trauma or associated with an auto-immune disease. Inflammation of the cornea commonly presents as a painful red eye with reduced visual acuity due to cellular infiltration and later

2010 GP Notebook

615. cranial nerves

strength corneal reflex, if appropriate VII furrowing of brow on frowning, raising of eyebrows show teeth, smile, puff out cheeks screwing up of eyes facial movement VIII repeat number whispered into each ear Rinne's test Weber's test IX, X palatal movement, difficulty swallowing, gag reflex quality of speech: nasal guttural say "ee" XI sternocleidomastoid and trapezius bulk and strength XII tongue at rest and on movements to command, e.g. protrude say "la" and "ta"; quality of articulation Links

2010 GP Notebook

616. examination of the patient with dizziness

for : signs of palsies and sensorineural hearing loss this includes particularly funduscopy for papilloedema or optic atrophy (II) eye movements (III, IV, and VI) corneal reflex (V) facial movement (VII) tuning folk tests for hearing loss(VIII) special attention is paid to those that pass through the cerebellopontine angle - the fifth to the seventh. nystagmus common in acute virtigo (2) vertical nystagmus (1) is commonly seen in vestibular nuclear or cerebellar vermis lesions horizontal nystagmus

2010 GP Notebook

617. clinical examination of the dizzy patient

for : signs of palsies and sensorineural hearing loss this includes particularly funduscopy for papilloedema or optic atrophy (II) eye movements (III, IV, and VI) corneal reflex (V) facial movement (VII) tuning folk tests for hearing loss(VIII) special attention is paid to those that pass through the cerebellopontine angle - the fifth to the seventh. nystagmus common in acute virtigo (2) vertical nystagmus (1) is commonly seen in vestibular nuclear or cerebellar vermis lesions horizontal nystagmus

2010 GP Notebook

618. keratitis (eye)

and later, corneal oedema blood vessel dilatation is typically concentrated around the limbus - circumcorneal injection often, the conjunctiva is also inflamed - keratoconjunctivitis discharge is usually present and may be watery, mucoid or purulent; notably, it is absent in keratoconjunctivitis sicca pupil may be small due to reflexive miosis; photophobia is common fluorescein readily demonstrates any ulceration (an epithelial breach) Keratitis an cause significant loss of vision from (1): scarring (...) keratitis (eye) keratitis (eye) - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search keratitis (eye) Keratitis is inflammation of the cornea. This may result from a variety of bacterial, viral or fungal infections, or may be non-infective, for example due to trauma or associated with an auto-immune disease. Inflammation of the cornea commonly presents as a painful red eye with reduced visual acuity due to cellular infiltration

2010 GP Notebook

619. Biograstim (filgrastim)

parameters were examined: body position; restlessness; writhing; stereotypic behaviour; convulsions; twitches and tremors; grooming; ease of removal; gait; palpebral closure; piloerection; respiratory rate/pattern; locomotor activity level; defecation/urination; escape response; lacrimation; pupil size; salivation; diarrhoea; body tone; staub tail; cutaneous blood flow; corneal reflex; pinna reflex; tail pinch; auricular startle; righting reflex; positional passivity; vocalisation; and geotropism

2008 European Medicines Agency - EPARs

620. Implantable miniature telescope for macualar degeneration (Update)

(Williams et al 1998; Tolman et al 2005). Designed for patients with advanced dry and wet stage AMD, the IMT is a prosthetic telescope device measuring 4.4mm in length and weighing 46.1mg in an aqueous environment. The device is implanted behind the pupil in the posterior chamber of one eye during an outpatient surgical procedure that takes approximately 45 minutes. Once implanted, the IMT together with the cornea functions as a telephoto lens, providing three times magnification on the retina (...) of visual tasks. External telescopes are generally cumbersome and cosmetically unappealing, and the visual field they offer is severely restricted (5 to 10 degrees, compared to 36 degrees for the IMT). Patients can also experience nausea when using external 2 Update Implantable miniature telescope for macular degeneration: August 2007 telescopes because of the vestibular ocular reflex conflict caused by the need to scan the visual field using head movement rather than natural eye movement (Peli 2002

2007 Australia and New Zealand Horizon Scanning Network

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