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41. Degeneration and Regeneration of Corneal Nerves in Response to HSV-1 Infection. (Full text)

Degeneration and Regeneration of Corneal Nerves in Response to HSV-1 Infection. Herpes simplex virus type 1 (HSV-1) infection is one cause of neurotrophic keratitis, characterized by decreases in corneal sensation, blink reflex, and tear secretion as consequence of damage to the sensory fibers innervating the cornea. Our aim was to characterize changes in the corneal nerve network and its function in response to HSV-1 infection.C57BL/6J mice were infected with HSV-1 or left uninfected. Corneas (...) were harvested at predetermined times post infection (pi) and assessed for β III tubulin, substance P, calcitonin gene-related peptide, and neurofilament H staining by immunohistochemistry (IHC). Corneal sensitivity was evaluated using a Cochet-Bonnet esthesiometer. Expression of genes associated with nerve repair was determined in corneas by real time RT-PCR, Western blotting, and IHC. Semaphorin 7A (SEMA 7A) neutralizing antibody or isotype control was subconjunctivally administered to infected

2015 Investigative Ophthalmology & Visual Science PubMed

42. Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy

Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy (CACICOL-PTK) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02373397 Recruitment Status : Terminated (Study terminated due to poor patient recruitment) First Posted

2015 Clinical Trials

43. Two target locations for corneal inlay implantation combined with laser in situ keratomileusis. (PubMed)

Two target locations for corneal inlay implantation combined with laser in situ keratomileusis. To compare the visual acuity outcomes between 2 target locations for corneal inlay implantation with concurrent laser in situ keratomileusis (LASIK) to compensate for presbyopia.Shinagawa LASIK Center, Tokyo, Japan.Retrospective cohort study.Bilateral LASIK was performed simultaneously with inlay implantation in the nondominant eye. The preoperative and 6-month postoperative uncorrected distance (...) (UDVA) and uncorrected near (UNVA) visual acuities were evaluated. Patients were divided into the following 2 groups based on the pupil center to Purkinje reflex distance (Pp-Pk): small (≤300 μm) and large (>300 μm). Each group was divided into subgroups according to the distance of the inlay center to the Purkinje reflex (I-Pk) or to the midpoint between the pupil center and Purkinje reflex (I-M). The inlay position was classified as 0 to 100 μm, 101 to 200 μm, 201 to 300 μm, and 301 to 400 μm from

2015 Journal of cataract and refractive surgery

44. Corneal nerves in health and disease. (Full text)

Corneal nerves in health and disease. Corneal nerves are responsible for the sensations of touch, pain, and temperature and play an important role in the blink reflex, wound healing, and tear production and secretion. Corneal nerve dysfunction is a frequent feature of diseases that cause opacities and result in corneal blindness. Corneal opacities rank as the second most frequent cause of blindness. Technological advances in in vivo corneal nerve imaging, such as optical coherence tomography (...) and confocal scanning, have generated new knowledge regarding the phenomenological events that occur during reinnervation of the cornea following disease, injury, or surgery. The recent availability of transgenic neurofluorescent murine models has stimulated the search for molecular modulators of corneal nerve regeneration. New evidence suggests that neuroregenerative and inflammatory pathways in the cornea are intertwined. Evidence-based treatment of neurotrophic corneal diseases includes using

2014 Survey of Ophthalmology PubMed

45. Corneal Lesions in Intensive Care Unit (ICU) Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing in the Adult Intensive Care Center Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing in the Adult Intens

Corneal Lesions in Intensive Care Unit (ICU) Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing in the Adult Intensive Care Center Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing in the Adult Intens Corneal Lesions in Intensive Care Unit (ICU) Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing in the Adult Intensive Care Center Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing (...) in the Adult Intensive Care Center - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Corneal Lesions in Intensive Care Unit (ICU) Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing in the Adult

2014 Clinical Trials

46. Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density and Neuropathic Symptoms of Subjects With Sarcoidosis

Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density and Neuropathic Symptoms of Subjects With Sarcoidosis Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density and Neuropathic Symptoms of Subjects With Sarcoidosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density and Neuropathic Symptoms of Subjects With Sarcoidosis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02039687 Recruitment Status : Completed First Posted : January 20, 2014

2014 Clinical Trials

47. Investigating the Association between Angiogenic Cytokines and Corneal Neovascularization in Sulfur Mustard Intoxicated Subjects 26 Years after Exposure (Full text)

Investigating the Association between Angiogenic Cytokines and Corneal Neovascularization in Sulfur Mustard Intoxicated Subjects 26 Years after Exposure This study aimed to evaluate the associations between the concentrations of three major angiogenic cytokines-vascular endothelial growth factor-A165 (VEGF-A165), basic fibroblast growth factor (bFGF), and platelet-derived growth factor-BB (PDGF-BB)-in the tear of sulfur mustard (SM)-exposed subjects and corneal neovascularization (CNV) 26 years (...) after exposure.The concentrations of VEGF-A, bFGF, and PDGF-BB were measured by enzyme-linked immunosorbent assay (ELISA) in reflex tears of (i) SM-injured patients with CNV (positive case group including 18 individuals) and (ii) SM-injured patients without CNV (negative case group including 22 individuals). Then results were compared to corresponding values obtained from tears of 40 healthy control subjects.The mean concentrations of all investigated growth factors, VEGF-A165, bFGF, and PDGF-BB

2014 Toxicology international PubMed

48. Endoilluminator-assisted transcorneal illumination for Descemet membrane endothelial keratoplasty: enhanced intraoperative visualization of the graft in corneal decompensation secondary to pseudophakic bullous keratopathy. (PubMed)

Endoilluminator-assisted transcorneal illumination for Descemet membrane endothelial keratoplasty: enhanced intraoperative visualization of the graft in corneal decompensation secondary to pseudophakic bullous keratopathy. Compromised visibility is problematic with Descemet membrane endothelial keratoplasty (DMEK), especially in the presence of corneal edema. Visibility may be enhanced by dehydrating the cornea preoperatively and by debriding the epithelium, staining the graft, and using (...) a handheld slitlamp during surgery. Because the DMEK graft is transparent, thin, and flimsy, it is difficult to confirm the position, orientation, and morphology even with a clearer cornea. We describe a technique (endoilluminator-assisted DMEK) for identifying graft orientation and enhancing 3-dimensional depth perception within the anterior chamber of the graft. The technique uses oblique light from the endoilluminator for better visualization. Light reflexes from graft folds and edges aid further

2014 Journal of cataract and refractive surgery

49. Corneal Abrasion (Follow-up)

. Previous Next: Anesthetics and Analgesics Topical anesthetic agents are used for analgesia to facilitate an adequate ophthalmologic examination. Traditionally, these agents have never been prescribed for home use, because they may cause a secondary keratitis, compromise epithelial wound healing, and block effective corneal protective reflexes and sensation. Although a recent study found the use of topical tetracaine for 24 hours in corneal abrasions to be safe, [ ] there was no significant difference (...) Corneal Abrasion (Follow-up) Emergency Care of Corneal Abrasion: Overview, Clinical Evaluation, ED Treatment Considerations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzk5MzE2LW92ZXJ2aWV3 processing

2014 eMedicine Emergency Medicine

50. Corneal Abrasion (Treatment)

. Previous Next: Anesthetics and Analgesics Topical anesthetic agents are used for analgesia to facilitate an adequate ophthalmologic examination. Traditionally, these agents have never been prescribed for home use, because they may cause a secondary keratitis, compromise epithelial wound healing, and block effective corneal protective reflexes and sensation. Although a recent study found the use of topical tetracaine for 24 hours in corneal abrasions to be safe, [ ] there was no significant difference (...) Corneal Abrasion (Treatment) Emergency Care of Corneal Abrasion: Overview, Clinical Evaluation, ED Treatment Considerations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzk5MzE2LW92ZXJ2aWV3 processing

2014 eMedicine Emergency Medicine

51. Corneal Abrasion (Diagnosis)

. Previous Next: Anesthetics and Analgesics Topical anesthetic agents are used for analgesia to facilitate an adequate ophthalmologic examination. Traditionally, these agents have never been prescribed for home use, because they may cause a secondary keratitis, compromise epithelial wound healing, and block effective corneal protective reflexes and sensation. Although a recent study found the use of topical tetracaine for 24 hours in corneal abrasions to be safe, [ ] there was no significant difference (...) Corneal Abrasion (Diagnosis) Emergency Care of Corneal Abrasion: Overview, Clinical Evaluation, ED Treatment Considerations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzk5MzE2LW92ZXJ2aWV3 processing

2014 eMedicine Emergency Medicine

52. Corneal Abrasion (Overview)

. Previous Next: Anesthetics and Analgesics Topical anesthetic agents are used for analgesia to facilitate an adequate ophthalmologic examination. Traditionally, these agents have never been prescribed for home use, because they may cause a secondary keratitis, compromise epithelial wound healing, and block effective corneal protective reflexes and sensation. Although a recent study found the use of topical tetracaine for 24 hours in corneal abrasions to be safe, [ ] there was no significant difference (...) Corneal Abrasion (Overview) Emergency Care of Corneal Abrasion: Overview, Clinical Evaluation, ED Treatment Considerations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzk5MzE2LW92ZXJ2aWV3 processing > Emergency

2014 eMedicine Emergency Medicine

53. Intracameral illuminator-assisted advanced cataract surgery combined with 23-gauge vitrectomy in eyes with poor red reflex. (PubMed)

and 23-gauge vitrectomy. The main outcome measures were causes of the poor red reflex, value of the intracameral illuminator in specific cataract steps, and intraoperative and postoperative complications.The study comprised 17 patients (17 eyes). The main causes of a poor red reflex were vitreous hemorrhage in 8 eyes, vitreous opacity in 6 eyes, and corneal opacity, bullous retinal detachment, and globe deviation in 1 eye each. Horizontal or oblique intracameral illumination minimized the amount (...) Intracameral illuminator-assisted advanced cataract surgery combined with 23-gauge vitrectomy in eyes with poor red reflex. To evaluate the efficacy and outcomes of intracameral illuminator-assisted advanced cataract surgery combined with 23-gauge vitrectomy in eyes with a poor red reflex.Department of Ophthalmology, Gachon University Gil Hospital, Incheon, Korea.Interventional case series.Surgeon-controlled intracameral illumination was used for visualization during combined cataract surgery

2013 Journal of cataract and refractive surgery

54. Structure-Function Relationship Between Corneal Nerves and Conventional Small-Fiber Tests in Type 1 Diabetes. (Full text)

corneal nerve structure, including corneal nerve fiber length (CNFL), fiber density (CNFD), branch density (CNBD), and fiber tortuosity (CNFT). Small nerve fiber function was assessed by cooling detection thresholds (CDTs), axon reflex-mediated neurogenic vasodilatation in response to cutaneous heating by laser Doppler imaging flare technique (LDIFLARE), and heart rate variability (HRV). Linear associations between structural and functional measures in type 1 diabetic subjects were determined using (...) Structure-Function Relationship Between Corneal Nerves and Conventional Small-Fiber Tests in Type 1 Diabetes. In vivo corneal confocal microscopy (IVCCM) has been proposed as a noninvasive technique to assess small nerve fiber structural morphology. We investigated the structure-function relationship of small fibers in diabetic sensorimotor polyneuropathy (DSP).Ninety-six type 1 diabetic subjects with a spectrum of clinical DSP and 64 healthy volunteers underwent IVCCM examinations to determine

2013 Diabetes Care PubMed

55. Corneal Confocal Microscopy to Detect Diabetic Neuropathy in Children

strength, knee and ankle reflexes, sensation in the great toes will be evaluated for light touch-pressure, temperature, pin-prick, vibratory sense and joint position sense. Normal controls Healthy children aged 8 to 18 years will undergo Corneal Confocal Microscopy, Nerve Conduction Studies, Quantitative sensory testing, Neuropathy Symptom Scoring and Clinical nerve examinations. Procedure: Corneal Confocal Microscopy Close-up pictures of the front part of the eye (the cornea) Procedure: Nerve (...) Corneal Confocal Microscopy to Detect Diabetic Neuropathy in Children Corneal Confocal Microscopy to Detect Diabetic Neuropathy in Children - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Corneal Confocal

2013 Clinical Trials

56. Anterior capsule staining using micronized triamcinolone in the absence of red reflex. (PubMed)

Anterior capsule staining using micronized triamcinolone in the absence of red reflex. We describe a technique to stain the anterior lens capsule with micronized triamcinolone to perform a continuous curvilinear capsulorhexis (CCC) during phacoemulsification in the absence of a red reflex due to vitreous hemorrhage. After a self-sealing clear corneal tunnel incision is performed using a 2.75 mm blade, a dispersive ophthalmic viscosurgical device (OVD) is injected to protect the iridocorneal (...) angle. An air bubble as large as possible is injected into the center of the anterior chamber, and a small amount of micronized triamcinolone is then injected as needed to stain the anterior lens capsule. The OVD injection permits the removal of excessive triamcinolone and protects the corneal endothelium from damage during phacoemulsification. A capsulorhexis forceps is used to perform the CCC.No author has a financial or proprietary interest in any material or method mentioned.Copyright © 2011

2011 Journal of cataract and refractive surgery

57. Influence of topical anesthetics on oculocardiac reflex and corneal healing in rabbits (Full text)

Influence of topical anesthetics on oculocardiac reflex and corneal healing in rabbits To investigate the incidence of oculocardiac reflex (OCR) with two anesthetic regimens and its prevention using topical anesthetics in a rabbit model, and to explore the effect of topical anesthetics on corneal healing.Forty-eight clinically healthy adult New Zealand white rabbits of either sex were divided into two groups (Group A and B) and anesthetized with either ketamine (Group A, n =24) or propofol (...) (Group B, n =24). he incidence of OCR was recorded in each group with a variety of ocular manipulation with or without the use of topical anesthetics (40g/L lignocaine, 5g/L proparacain, 5g/L bupivacaine). Corneal toxicity and healing following the use of each topical anesthetic was assessed one day after surgery and up to 7 days postoperatively by clinical examination of the eye, histopathology and collagen staining and transmission electron microscopy.No incidence of OCR was recorded with ocular

2010 International journal of ophthalmology PubMed

58. Dependence of Corneal Stem/Progenitor Cells on Ocular Surface Innervation. (Full text)

model of NK.NK was induced in mice by electrocoagulation of the ophthalmic branch of the trigeminal nerve. The absence of corneal nerves was confirmed with β-III tubulin immunostaining and blink reflex test after 7 days. ATP-binding cassette subfamily G member 2 (ABCG2), p63, and hairy enhancer of split 1 (Hes1) were chosen as corneolimbal stem/progenitor cell markers and assessed in denervated mice versus controls by immunofluorescent microscopy and real-time PCR. In addition, corneolimbal stem (...) Dependence of Corneal Stem/Progenitor Cells on Ocular Surface Innervation. Neurotrophic keratopathy (NK) is a corneal degeneration associated with corneal nerve dysfunction. It can cause corneal epithelial defects, stromal thinning, and perforation. However, it is not clear if and to which extent epithelial stem cells are affected in NK. The purpose of this study was to identify the relationship between corneolimbal epithelial progenitor/stem cells and sensory nerves using a denervated mouse

2012 Investigative Ophthalmology & Visual Science PubMed

59. Optical modeling of a corneal inlay in real eyes to increase depth of focus: optimum centration and residual defocus. (PubMed)

in diameter was placed at the corneal plane in each model. The monochromatic and polychromatic Strehl ratios were calculated as a function of the pinhole position. Different residual defocus values were also incorporated into the models, and the through-focus Strehl ratios were calculated.Sixteen eye models were built. For most subjects, the optimum location of the aperture for distance vision was close to the corneal reflex position. For a given optimized centration of the aperture, the best compromise (...) of depth of focus was obtained when the eyes had some residual myopic defocus (range -0.75 to -1.00 diopter [D]). Strehl ratio values were over 0.1 for far distance, which led to visual acuities better than 20/20. The depth of focus was 2.50 D with a mean near visual acuity of Jaeger 1 or better.In eyes with little astigmatism and aberrations, the optimum centration of the small aperture was near the corneal reflex position. To improve optical outcomes with the inlay, some small residual myopia

2012 Journal of cataract and refractive surgery

60. The Application of Cultured Cornea Stem Cells in Patients Suffering From Corneal Stem Cell Insufficiency

of surface matrix peripheral surface matrix is less than 200um thick no corneal reflex was induced by fiber less than 5mm length measured by Cocet-Bonnet esthesiometer improvement under medication perisurgical follow up less than 6 months unable to be long term followed up postoperatively glaucoma patients underwent glaucoma surgery, under medication, IOP > 21mmHg glaucoma patients underwent glaucoma surgery, under medication, IOP < 21mmHg, optic disc depression > 90% severe incomplete eyelid closure (...) The Application of Cultured Cornea Stem Cells in Patients Suffering From Corneal Stem Cell Insufficiency The Application of Cultured Cornea Stem Cells in Patients Suffering From Corneal Stem Cell Insufficiency - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2011 Clinical Trials

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