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Corneal Reflex

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41. Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy

population undergoing therapeutic laser treatment for corneal dystrophy or recurrent corneal erosions. Condition or disease Intervention/treatment Phase Corneal Dystrophy, Epithelial Basement Membrane Epithelial Recurrent Erosion Dystrophy Corneal Erosions Device: Cacicol20 Device: Placebo Phase 4 Detailed Description: Patients undergoing various surgical treatments of the cornea often suffer from a neural deficit, due to nerves being severed or removed completely during surgery. This can result in pain (...) , impaired epithelial wound healing, reduced tear production, symptoms of dry eye, and loss of ocular surface sensitivity/blink reflex. In addition, surgical wound healing can be accompanied by undesirable formation of scar tissue, which can limit postoperative visual acuity. The investigators' prior clinical experience with patients having undergone surgery of the anterior cornea is that neural recovery is slow and incomplete, while in certain situations scar tissue can form and limit the visual

2015 Clinical Trials

42. Degeneration and Regeneration of Corneal Nerves in Response to HSV-1 Infection. Full Text available with Trip Pro

Degeneration and Regeneration of Corneal Nerves in Response to HSV-1 Infection. Herpes simplex virus type 1 (HSV-1) infection is one cause of neurotrophic keratitis, characterized by decreases in corneal sensation, blink reflex, and tear secretion as consequence of damage to the sensory fibers innervating the cornea. Our aim was to characterize changes in the corneal nerve network and its function in response to HSV-1 infection.C57BL/6J mice were infected with HSV-1 or left uninfected. Corneas (...) were harvested at predetermined times post infection (pi) and assessed for β III tubulin, substance P, calcitonin gene-related peptide, and neurofilament H staining by immunohistochemistry (IHC). Corneal sensitivity was evaluated using a Cochet-Bonnet esthesiometer. Expression of genes associated with nerve repair was determined in corneas by real time RT-PCR, Western blotting, and IHC. Semaphorin 7A (SEMA 7A) neutralizing antibody or isotype control was subconjunctivally administered to infected

2015 Investigative Ophthalmology & Visual Science

43. Transglutaminase binding fusion protein linked to SLPI reduced corneal inflammation and neovascularization. Full Text available with Trip Pro

staining at 18 and 24 hours. In the remaining animals corneal opacity was studied and digital photographs were taken at day 7 before doing euthanasia. Eyes were processed for histology and immunofluorescence.Corneal ulcerated area was significantly lower in PF-MC treated animals compared to SLPI and buffer-treated animals at 18 hours and 24 hours postinjury. A clear cornea and fundus red reflex was only found among PF-MC treated animals. Histological analysis revealed a stratified corneal epithelium (...) Transglutaminase binding fusion protein linked to SLPI reduced corneal inflammation and neovascularization. To study the effect of topical administration of a fusion protein (PF-MC) made up of N-terminal portion of the protease inhibitor Trappin-2 (which is a substrate of transglutaminasa-2) and SLPI (protein with anti-inflammatory, anti-bacterial and anti-viral ability), in an animal model of corneal inflammation and angiogenesis.An alkali injury was produced with a filter paper of 3 mm with 1

2015 BMC Ophthalmology

44. Intracameral illuminator-assisted advanced cataract surgery combined with 23-gauge vitrectomy in eyes with poor red reflex. (Abstract)

and 23-gauge vitrectomy. The main outcome measures were causes of the poor red reflex, value of the intracameral illuminator in specific cataract steps, and intraoperative and postoperative complications.The study comprised 17 patients (17 eyes). The main causes of a poor red reflex were vitreous hemorrhage in 8 eyes, vitreous opacity in 6 eyes, and corneal opacity, bullous retinal detachment, and globe deviation in 1 eye each. Horizontal or oblique intracameral illumination minimized the amount (...) Intracameral illuminator-assisted advanced cataract surgery combined with 23-gauge vitrectomy in eyes with poor red reflex. To evaluate the efficacy and outcomes of intracameral illuminator-assisted advanced cataract surgery combined with 23-gauge vitrectomy in eyes with a poor red reflex.Department of Ophthalmology, Gachon University Gil Hospital, Incheon, Korea.Interventional case series.Surgeon-controlled intracameral illumination was used for visualization during combined cataract surgery

2013 Journal of cataract and refractive surgery

45. Endoilluminator-assisted transcorneal illumination for Descemet membrane endothelial keratoplasty: enhanced intraoperative visualization of the graft in corneal decompensation secondary to pseudophakic bullous keratopathy. (Abstract)

Endoilluminator-assisted transcorneal illumination for Descemet membrane endothelial keratoplasty: enhanced intraoperative visualization of the graft in corneal decompensation secondary to pseudophakic bullous keratopathy. Compromised visibility is problematic with Descemet membrane endothelial keratoplasty (DMEK), especially in the presence of corneal edema. Visibility may be enhanced by dehydrating the cornea preoperatively and by debriding the epithelium, staining the graft, and using (...) a handheld slitlamp during surgery. Because the DMEK graft is transparent, thin, and flimsy, it is difficult to confirm the position, orientation, and morphology even with a clearer cornea. We describe a technique (endoilluminator-assisted DMEK) for identifying graft orientation and enhancing 3-dimensional depth perception within the anterior chamber of the graft. The technique uses oblique light from the endoilluminator for better visualization. Light reflexes from graft folds and edges aid further

2014 Journal of cataract and refractive surgery

46. Investigating the Association between Angiogenic Cytokines and Corneal Neovascularization in Sulfur Mustard Intoxicated Subjects 26 Years after Exposure Full Text available with Trip Pro

Investigating the Association between Angiogenic Cytokines and Corneal Neovascularization in Sulfur Mustard Intoxicated Subjects 26 Years after Exposure This study aimed to evaluate the associations between the concentrations of three major angiogenic cytokines-vascular endothelial growth factor-A165 (VEGF-A165), basic fibroblast growth factor (bFGF), and platelet-derived growth factor-BB (PDGF-BB)-in the tear of sulfur mustard (SM)-exposed subjects and corneal neovascularization (CNV) 26 years (...) after exposure.The concentrations of VEGF-A, bFGF, and PDGF-BB were measured by enzyme-linked immunosorbent assay (ELISA) in reflex tears of (i) SM-injured patients with CNV (positive case group including 18 individuals) and (ii) SM-injured patients without CNV (negative case group including 22 individuals). Then results were compared to corresponding values obtained from tears of 40 healthy control subjects.The mean concentrations of all investigated growth factors, VEGF-A165, bFGF, and PDGF-BB

2014 Toxicology international

47. Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density and Neuropathic Symptoms of Subjects With Sarcoidosis

, and measurement of nerve fibers in their cornea and skin (via a non-invasive test and a biopsy, respectively). The total participation time for each patient will be 16 weeks. Condition or disease Intervention/treatment Phase Neuropathy of Sarcoidosis Drug: ARA 290 Other: Placebo Phase 2 Detailed Description: This was a double-blind, randomized, placebo-controlled study to assess the effects of daily SC administration of ARA 290 at a dose of 1 mg, 4 mg, or 8 mg or placebo on corneal nerve fiber density (...) Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density and Neuropathic Symptoms of Subjects With Sarcoidosis Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density and Neuropathic Symptoms of Subjects With Sarcoidosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2014 Clinical Trials

48. Corneal Lesions in Intensive Care Unit (ICU) Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing in the Adult Intensive Care Center Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing in the Adult Intens

Corneal Lesions in Intensive Care Unit (ICU) Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing in the Adult Intensive Care Center Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing in the Adult Intens Corneal Lesions in Intensive Care Unit (ICU) Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing in the Adult Intensive Care Center Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing (...) in the Adult Intensive Care Center - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Corneal Lesions in Intensive Care Unit (ICU) Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing in the Adult

2014 Clinical Trials

49. Corneal nerves in health and disease. Full Text available with Trip Pro

Corneal nerves in health and disease. Corneal nerves are responsible for the sensations of touch, pain, and temperature and play an important role in the blink reflex, wound healing, and tear production and secretion. Corneal nerve dysfunction is a frequent feature of diseases that cause opacities and result in corneal blindness. Corneal opacities rank as the second most frequent cause of blindness. Technological advances in in vivo corneal nerve imaging, such as optical coherence tomography (...) and confocal scanning, have generated new knowledge regarding the phenomenological events that occur during reinnervation of the cornea following disease, injury, or surgery. The recent availability of transgenic neurofluorescent murine models has stimulated the search for molecular modulators of corneal nerve regeneration. New evidence suggests that neuroregenerative and inflammatory pathways in the cornea are intertwined. Evidence-based treatment of neurotrophic corneal diseases includes using

2014 Survey of Ophthalmology

50. Corneal Abrasion (Diagnosis)

> Emergency Care of Corneal Abrasion Updated: May 31, 2017 Author: Feras H Khan, MD; Chief Editor: Barry E Brenner, MD, PhD, FACEP Share Email Print Feedback Close Sections Sections Emergency Care of Corneal Abrasion Overview Overview The cornea is a transparent cover over the anterior part of the eye that serves several purposes, such as protection, refraction, and filtration of some ultraviolet light. This structure has no blood vessels and receives nutrients through tears as well as from the aqueous (...) humor. The cornea is innervated primarily by the ophthalmic division of the trigeminal nerve and the oculomotor nerve. Although the exact frequency of emergency department visits for corneal abrasions is unknown, a 1985 survey showed that around 3% of all cases to US general practitioners were corneal abrasions. [ ] In addition, in 2008, approximately 27,450 work-related eye injuries and illnesses occurred that caused missed time from work. [ ] See the following image. Corneal foreign body

2014 eMedicine Emergency Medicine

51. Corneal Abrasion (Follow-up)

> Emergency Care of Corneal Abrasion Updated: May 31, 2017 Author: Feras H Khan, MD; Chief Editor: Barry E Brenner, MD, PhD, FACEP Share Email Print Feedback Close Sections Sections Emergency Care of Corneal Abrasion Overview Overview The cornea is a transparent cover over the anterior part of the eye that serves several purposes, such as protection, refraction, and filtration of some ultraviolet light. This structure has no blood vessels and receives nutrients through tears as well as from the aqueous (...) humor. The cornea is innervated primarily by the ophthalmic division of the trigeminal nerve and the oculomotor nerve. Although the exact frequency of emergency department visits for corneal abrasions is unknown, a 1985 survey showed that around 3% of all cases to US general practitioners were corneal abrasions. [ ] In addition, in 2008, approximately 27,450 work-related eye injuries and illnesses occurred that caused missed time from work. [ ] See the following image. Corneal foreign body

2014 eMedicine Emergency Medicine

52. Corneal Abrasion (Treatment)

> Emergency Care of Corneal Abrasion Updated: May 31, 2017 Author: Feras H Khan, MD; Chief Editor: Barry E Brenner, MD, PhD, FACEP Share Email Print Feedback Close Sections Sections Emergency Care of Corneal Abrasion Overview Overview The cornea is a transparent cover over the anterior part of the eye that serves several purposes, such as protection, refraction, and filtration of some ultraviolet light. This structure has no blood vessels and receives nutrients through tears as well as from the aqueous (...) humor. The cornea is innervated primarily by the ophthalmic division of the trigeminal nerve and the oculomotor nerve. Although the exact frequency of emergency department visits for corneal abrasions is unknown, a 1985 survey showed that around 3% of all cases to US general practitioners were corneal abrasions. [ ] In addition, in 2008, approximately 27,450 work-related eye injuries and illnesses occurred that caused missed time from work. [ ] See the following image. Corneal foreign body

2014 eMedicine Emergency Medicine

53. Corneal Abrasion (Overview)

Care of Corneal Abrasion Updated: May 31, 2017 Author: Feras H Khan, MD; Chief Editor: Barry E Brenner, MD, PhD, FACEP Share Email Print Feedback Close Sections Sections Emergency Care of Corneal Abrasion Overview Overview The cornea is a transparent cover over the anterior part of the eye that serves several purposes, such as protection, refraction, and filtration of some ultraviolet light. This structure has no blood vessels and receives nutrients through tears as well as from the aqueous humor (...) . The cornea is innervated primarily by the ophthalmic division of the trigeminal nerve and the oculomotor nerve. Although the exact frequency of emergency department visits for corneal abrasions is unknown, a 1985 survey showed that around 3% of all cases to US general practitioners were corneal abrasions. [ ] In addition, in 2008, approximately 27,450 work-related eye injuries and illnesses occurred that caused missed time from work. [ ] See the following image. Corneal foreign body with cobalt blue

2014 eMedicine Emergency Medicine

54. Comparison of wavefront-guided aspheric laser in situ keratomileusis for myopia: coaxially sighted corneal-light-reflex versus line-of-sight centration. (Abstract)

Comparison of wavefront-guided aspheric laser in situ keratomileusis for myopia: coaxially sighted corneal-light-reflex versus line-of-sight centration. To compare refractive outcomes, higher-order aberrations (HOAs), and contrast sensitivity of myopic wavefront-guided aspheric laser in situ keratomileusis centered on the coaxially sighted corneal light reflex or on the line of sight.Okamoto Eye Clinic, Ehime, Japan.Comparative case series.Data at 3 months were compared based on the distance (...) between the coaxially sighted corneal light reflex and the line of sight (P-distance) as follows: distance greater than 0.25 mm (high-distance group), distance greater than 0.15 mm and less than 0.25 mm (intermediate-distance group), and distance less than 0.15 mm (low distance group).The chart review included 317 eyes in the corneal-light-reflex group and 269 eyes in the line-of-sight group. The mean postoperative manifest refraction spherical equivalent was +0.123 diopter (D) ± 0.378 (SD) and +0.187

2011 Journal of cataract and refractive surgery

55. Corneal Confocal Microscopy to Detect Diabetic Neuropathy in Children

strength, knee and ankle reflexes, sensation in the great toes will be evaluated for light touch-pressure, temperature, pin-prick, vibratory sense and joint position sense. Normal controls Healthy children aged 8 to 18 years will undergo Corneal Confocal Microscopy, Nerve Conduction Studies, Quantitative sensory testing, Neuropathy Symptom Scoring and Clinical nerve examinations. Procedure: Corneal Confocal Microscopy Close-up pictures of the front part of the eye (the cornea) Procedure: Nerve (...) testing, Neuropathy Symptom Scoring and Clinical nerve examinations. Procedure: Corneal Confocal Microscopy Close-up pictures of the front part of the eye (the cornea) Procedure: Nerve Conduction Studies The following assessments will be made: a) amplitude of nerve action potential (μV) and conduction velocity (m/s) of the sural sensory nerve by antidromic stimulation; b) motor nerve conduction velocity (m/s), maximum M-wave amplitude (mV) and motor nerve distal latency (ms) of the peroneal motor

2013 Clinical Trials

56. Structure-Function Relationship Between Corneal Nerves and Conventional Small-Fiber Tests in Type 1 Diabetes. Full Text available with Trip Pro

corneal nerve structure, including corneal nerve fiber length (CNFL), fiber density (CNFD), branch density (CNBD), and fiber tortuosity (CNFT). Small nerve fiber function was assessed by cooling detection thresholds (CDTs), axon reflex-mediated neurogenic vasodilatation in response to cutaneous heating by laser Doppler imaging flare technique (LDIFLARE), and heart rate variability (HRV). Linear associations between structural and functional measures in type 1 diabetic subjects were determined using (...) Structure-Function Relationship Between Corneal Nerves and Conventional Small-Fiber Tests in Type 1 Diabetes. In vivo corneal confocal microscopy (IVCCM) has been proposed as a noninvasive technique to assess small nerve fiber structural morphology. We investigated the structure-function relationship of small fibers in diabetic sensorimotor polyneuropathy (DSP).Ninety-six type 1 diabetic subjects with a spectrum of clinical DSP and 64 healthy volunteers underwent IVCCM examinations to determine

2013 Diabetes Care

57. Dependence of Corneal Stem/Progenitor Cells on Ocular Surface Innervation. Full Text available with Trip Pro

model of NK.NK was induced in mice by electrocoagulation of the ophthalmic branch of the trigeminal nerve. The absence of corneal nerves was confirmed with β-III tubulin immunostaining and blink reflex test after 7 days. ATP-binding cassette subfamily G member 2 (ABCG2), p63, and hairy enhancer of split 1 (Hes1) were chosen as corneolimbal stem/progenitor cell markers and assessed in denervated mice versus controls by immunofluorescent microscopy and real-time PCR. In addition, corneolimbal stem (...) Dependence of Corneal Stem/Progenitor Cells on Ocular Surface Innervation. Neurotrophic keratopathy (NK) is a corneal degeneration associated with corneal nerve dysfunction. It can cause corneal epithelial defects, stromal thinning, and perforation. However, it is not clear if and to which extent epithelial stem cells are affected in NK. The purpose of this study was to identify the relationship between corneolimbal epithelial progenitor/stem cells and sensory nerves using a denervated mouse

2012 Investigative Ophthalmology & Visual Science

58. Optical modeling of a corneal inlay in real eyes to increase depth of focus: optimum centration and residual defocus. (Abstract)

in diameter was placed at the corneal plane in each model. The monochromatic and polychromatic Strehl ratios were calculated as a function of the pinhole position. Different residual defocus values were also incorporated into the models, and the through-focus Strehl ratios were calculated.Sixteen eye models were built. For most subjects, the optimum location of the aperture for distance vision was close to the corneal reflex position. For a given optimized centration of the aperture, the best compromise (...) of depth of focus was obtained when the eyes had some residual myopic defocus (range -0.75 to -1.00 diopter [D]). Strehl ratio values were over 0.1 for far distance, which led to visual acuities better than 20/20. The depth of focus was 2.50 D with a mean near visual acuity of Jaeger 1 or better.In eyes with little astigmatism and aberrations, the optimum centration of the small aperture was near the corneal reflex position. To improve optical outcomes with the inlay, some small residual myopia

2012 Journal of cataract and refractive surgery

59. A new mucolipidosis with psychomotor retardation, corneal clouding, and retinal degeneration. Full Text available with Trip Pro

A new mucolipidosis with psychomotor retardation, corneal clouding, and retinal degeneration. A man now 22 years of age had slow psychomotor development about 6 months after birth and developed intermittent corneal clouding at about 18 months. He developed truncal ataxia, hypotonia of the limbs combined with spasticity, and active deep reflexes. These have not progressed. His skeleton and facies are normal. Between his first and thriteenth year he developed sev ere optic atrophy, absence

1975 Transactions of the American Ophthalmological Society

60. Proceedings: Depletion of acetylcholine in the corneal epithelium. Full Text available with Trip Pro

pharmacology Cornea analysis physiology Depression, Chemical Epithelium analysis Naphthalenes pharmacology Pyridines pharmacology Rabbits Reflex drug effects Vinyl Compounds pharmacology 1973 9 1 1973 9 1 0 1 1973 9 1 0 0 ppublish 4787540 PMC1776399 Biochim Biophys Acta. 1970 May 13;206(2):242-51 5421956 Biochem Pharmacol. 1971 Oct;20(10):2741-8 5114509 (...) Proceedings: Depletion of acetylcholine in the corneal epithelium. 4787540 1974 06 12 2018 11 13 0007-1188 49 1 1973 Sep British journal of pharmacology Br. J. Pharmacol. Proceedings: Depletion of acetylcholine in the corneal epithelium. 167P Stevenson R W RW Wilson W S WS eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Cholinesterase Inhibitors 0 Naphthalenes 0 Pyridines 0 Vinyl Compounds N9YNS0M02X Acetylcholine IM Acetylcholine analysis Animals Cholinesterase Inhibitors

1973 British journal of pharmacology

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