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Corneal Reflex

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21. A Study Raindrop Near Vision Inlay in Presbyopes Implanted in Corneal Pockets

with high pressures during suction application. 1.1.15 Patients with known history of steroid-responsive intraocular pressure increases, glaucoma, preoperative IOP > 21 mm Hg, or are otherwise suspected of having glaucoma. 1.1.16 Patients with amblyopia or strabismus or those who are at risk for developing strabismus postoperatively as determined by corneal light reflex and cover-uncover testing. 1.1.17 Patients with diabetic retinopathy, collagen, vascular, diagnosed autoimmune disease (e.g., lupus (...) A Study Raindrop Near Vision Inlay in Presbyopes Implanted in Corneal Pockets A Study Raindrop Near Vision Inlay in Presbyopes Implanted in Corneal Pockets - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2017 Clinical Trials

22. Changes of corneal tomography in patients with congenital blepharoptosis (Full text)

Changes of corneal tomography in patients with congenital blepharoptosis The study aimed to evaluate the effect of drooped eyelid on corneal tomography in congenital blepharoptosis patients. Sixty-four patients with congenital blepharoptosis and 64 age- and sex- matched healthy subjects were included. According to the eyelid margin to corneal light reflex distance (MRD), eyes with congenital blepharoptosis were categorized as mild, moderate, or severe. The eyes were scanned using the rotating (...) Scheimpflug camera. Increased topometric parameters were observed in moderate and severe blepharoptosis. Back corneal elevations at the thinnest point were significant higher for mild (P = 0.009), moderate (P < 0.001), and severe (P < 0.001) congenital blepharoptosis compared with controls. Maximum Ambrósio's relational thickness (ART) was decreased in eyes with severe blepharoptosis (P < 0.001). Fnal D values were significantly higher in moderate (P < 0.001) and severe blepharoptosis (P < 0.001) groups

2017 Scientific reports PubMed

23. Neurotrophic factors and corneal nerve regeneration (Full text)

Neurotrophic factors and corneal nerve regeneration The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination. Corneal sensitivity is provided by the ophthalmic branch of the trigeminal nerve that elicits protective reflexes such as blinking and tearing and exerts trophic support by releasing neuromediators and growth factors (...) . Corneal nerves are easily evaluated for both function and morphology using standard instruments such as corneal esthesiometer and in vivo confocal microscope. All local and systemic conditions that are associated with damage of the trigeminal nerve cause the development of neurotrophic keratitis, a rare degenerative disease. Neurotrophic keratitis is characterized by impairment of corneal sensitivity associated with development of persistent epithelial defects that may progress to corneal ulcer

2017 Neural Regeneration Research PubMed

24. Defining a mechanistic link between pigment epithelium–derived factor, docosahexaenoic acid, and corneal nerve regeneration (Full text)

Defining a mechanistic link between pigment epithelium–derived factor, docosahexaenoic acid, and corneal nerve regeneration The cornea is densely innervated to sustain the integrity of the ocular surface. Corneal nerve damage produced by aging, diabetes, refractive surgeries, and viral or bacterial infections impairs tear production, the blinking reflex, and epithelial wound healing, resulting in loss of transparency and vision. A combination of the known neuroprotective molecule, pigment (...) epithelium-derived factor (PEDF) plus docosahexaenoic acid (DHA), has been shown to stimulate corneal nerve regeneration, but the mechanisms involved are unclear. Here, we sought to define the molecular events of this effect in an in vivo mouse injury model. We first confirmed that PEDF + DHA increased nerve regeneration in the mouse cornea. Treatment with PEDF activates the phospholipase A2 activity of the PEDF-receptor (PEDF-R) leading to the release of DHA; this free DHA led to enhanced docosanoid

2017 The Journal of biological chemistry PubMed

25. Pharmacology of reflex blinks in the rat: a novel model for headache research (Full text)

blinks in the anaesthetised rat to determine whether such reflexes may prove useful as the basis for a novel animal model to evaluate potential anti-migraine therapeutic agents.In anaesthetised rats the electromyogram associated with the reflex blink evoked by corneal airpuff was recorded. Rats were infused with glyceryl trinitrate, sumatriptan plus glyceryl trinitrate or vehicle control. Changes in the magnitude of the reflex blink-associated electromyogram following these treatments were (...) Pharmacology of reflex blinks in the rat: a novel model for headache research Migraineurs are highly sensitive to the nitric oxide donor glyceryl trinitrate which triggers attacks in many sufferers. In animal studies, glyceryl trinitrate increases neuronal activity in the trigeminovascular pathway and elevates neurotransmitter levels in the brainstem. Many migraineurs also display alterations in blink reflexes, known to involve brainstem circuits. We investigated the effect of GTN on evoked

2016 The journal of headache and pain PubMed

26. Corneal Light Reflex

Corneal Light Reflex Corneal Light Reflex Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Corneal Light Reflex Corneal Light Reflex (...) Aka: Corneal Light Reflex , Hirschberg Test II. Indications: Strabismus Testing Differentiate true deviation from pseudostrabismus (due to wide nasal bridge or epicanthal folds) In uncooperative child, only test of alignment III. Technique Hold penlight at arms length in front of child Gain child's attention blink/tap light When child fixated on light Examiner lines up light with her eyes Note position of Corneal Light Reflex on each eye IV. Interpretation based on Corneal Light Reflex position

2015 FP Notebook

27. Corneal Reflex

Corneal Reflex Corneal Reflex Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Corneal Reflex Corneal Reflex Aka: Corneal Reflex (...) in those who use es Intact reflex suggests intact function VI. Resources at wikipedia VII. References Degowin (1987) Diagnostic Examination, 5th ed, MacMillan Publishing Company, p. 810 Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Corneal Reflex." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Corneal Reflexes (C0520451) Concepts Organ

2015 FP Notebook

28. Comparison of wavefront-guided aspheric laser in situ keratomileusis for myopia: coaxially sighted corneal-light-reflex versus line-of-sight centration. (PubMed)

Comparison of wavefront-guided aspheric laser in situ keratomileusis for myopia: coaxially sighted corneal-light-reflex versus line-of-sight centration. To compare refractive outcomes, higher-order aberrations (HOAs), and contrast sensitivity of myopic wavefront-guided aspheric laser in situ keratomileusis centered on the coaxially sighted corneal light reflex or on the line of sight.Okamoto Eye Clinic, Ehime, Japan.Comparative case series.Data at 3 months were compared based on the distance (...) between the coaxially sighted corneal light reflex and the line of sight (P-distance) as follows: distance greater than 0.25 mm (high-distance group), distance greater than 0.15 mm and less than 0.25 mm (intermediate-distance group), and distance less than 0.15 mm (low distance group).The chart review included 317 eyes in the corneal-light-reflex group and 269 eyes in the line-of-sight group. The mean postoperative manifest refraction spherical equivalent was +0.123 diopter (D) ± 0.378 (SD) and +0.187

2011 Journal of cataract and refractive surgery

29. Corneal Sensitivity to Hyperosmolar Eye Drops: A Novel Behavioral Assay to Assess Diabetic Peripheral Neuropathy. (Full text)

sophisticated instrumentation, expertise in confocal imaging, cooperative patients, and automated analysis tools to derive corneal nerve density. As an alternative, we developed a simple screening method that is based on the sensitivity of corneal nerves to cause reflex eyelid squinting in response to hyperosmolar eye drops.Eyes of control and type 2 diabetic rats were given an eye drop of a 290- to 900-mOsm solution, and the ocular response was video recorded. Other neuropathic end points including nerve (...) Corneal Sensitivity to Hyperosmolar Eye Drops: A Novel Behavioral Assay to Assess Diabetic Peripheral Neuropathy. Diagnosis of peripheral neuropathy (PN), which affects approximately 50% of the diabetic population, is subjective, with many patients seeking a diagnosis only after presenting with symptoms. Recently, in vivo confocal microscopy of subepithelial corneal nerve density has been promoted as a surrogate marker for early detection of PN, but imaging of corneal nerves requires

2016 Investigative Ophthalmology & Visual Science PubMed

30. Dorsally located corneal dermoid in a cat (Full text)

Dorsally located corneal dermoid in a cat A 2-month-old, male kitten was presented for evaluation of unilateral blepharospasm and epiphora involving the right eye. Ocular examination revealed conjunctivitis, a superficial corneal ulcer, reflex anterior uveitis and a haired mass within the dorsal cornea of the right eye. The mass was subsequently removed surgically via a lamellar keratectomy. Histologic evaluation of the mass via light microscopy revealed it to be comprised of normal-haired skin (...) with mild inflammation. One week after surgical removal and medical management of the corneal ulcer, all ocular clinical signs had resolved with minimal corneal scarring. On re-examination 6 months following surgical excision of the mass, the kitten was noted to be comfortable with no significant corneal scarring.To our knowledge, this is the first case report of a dorsally located corneal dermoid in a cat.

2016 JFMS Open Reports PubMed

31. Understanding Neuropathic Corneal Pain-Gaps and Current Therapeutic Approaches (Full text)

to elucidate the pathophysiology and neurobiology of pain resulting from initially protective physiological reflexes, to a more persistent chronic state. The goal of this clinical review is to briefly summarize the pathophysiology of neuropathic corneal pain, describe how to systematically approach the diagnosis of these patients, and finally summarizing our experience with current therapeutic approaches for the treatment of corneal neuropathic pain. (...) Understanding Neuropathic Corneal Pain-Gaps and Current Therapeutic Approaches The richly innervated corneal tissue is one of the most powerful pain generators in the body. Corneal neuropathic pain results from dysfunctional nerves causing perceptions such as burning, stinging, eye-ache, and pain. Various inflammatory diseases, neurological diseases, and surgical interventions can be the underlying cause of corneal neuropathic pain. Recent efforts have been made by the scientific community

2016 Seminars in Ophthalmology PubMed

32. Corneal reflex in hemisphere disease (Full text)

Corneal reflex in hemisphere disease The contralateral corneal reflex may be absent in patients with a deep lesion of the parietal lobe. Frontal and temporal lobe lesions apparently do not interfere with this reflex.

1972 Journal of neurology, neurosurgery, and psychiatry PubMed

33. THE CORNEAL REFLEX THE MOST RELIABLE GUIDE IN ANAESTHESIA (Full text)

THE CORNEAL REFLEX THE MOST RELIABLE GUIDE IN ANAESTHESIA 20761914 2011 03 29 2011 03 29 0007-1447 1 2301 1905 Feb 04 British medical journal Br Med J THE CORNEAL REFLEX THE MOST RELIABLE GUIDE IN ANAESTHESIA. 244-5 Gardner H B HB eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1905 2 4 0 0 1905 2 4 0 1 ppublish 20761914 PMC2319119

1905 British medical journal PubMed

34. THE CORNEAL REFLEX IN ANAESTHESIA (Full text)

THE CORNEAL REFLEX IN ANAESTHESIA 20762065 2011 03 29 2011 03 29 0007-1447 1 2312 1905 Apr 22 British medical journal Br Med J THE CORNEAL REFLEX IN ANAESTHESIA. 880 Thomas L K LK eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1905 4 22 0 0 1905 4 22 0 1 ppublish 20762065 PMC2320024

1905 British medical journal PubMed

35. Effect of stimulus size and luminance on the rod-, cone-, and melanopsin-mediated pupillary light reflex. (Full text)

Effect of stimulus size and luminance on the rod-, cone-, and melanopsin-mediated pupillary light reflex. This study determined if the pupillary light reflex (PLR) driven by brief stimulus presentations can be accounted for by the product of stimulus luminance and area (i.e., corneal flux density, CFD) under conditions biased toward the rod, cone, and melanopsin pathways. Five visually normal subjects participated in the study. Stimuli consisted of 1-s short- and long-wavelength flashes

2015 Journal of vision PubMed

36. Optical Zone Centration Accuracy Using Corneal Fixation-based SMILE Compared to Eye Tracker-based Femtosecond Laser-assisted LASIK for Myopia. (PubMed)

treated with LASIK (the LASIK group) with VisuMax flap creation and eye tracker-based centration MEL 90 excimer laser (Carl Zeiss Meditec) ablation. In SMILE, the corneal vertex of the coaxially fixating eye was aligned with the vertex of the curved contact glass. In LASIK, the treatment was centered on the coaxially sighted corneal light reflex (first Purkinje image). A tangential (instantaneous) curvature preoperative to postoperative difference map was generated for each eye. A fixed grid and set (...) Optical Zone Centration Accuracy Using Corneal Fixation-based SMILE Compared to Eye Tracker-based Femtosecond Laser-assisted LASIK for Myopia. To compare the optical zone centration accuracy between myopic eyes treated with small incision lenticule extraction (SMILE) and LASIK.Retrospective analysis of 100 consecutive eyes treated with SMILE (the SMILE group) with the corneal fixation-based centration VisuMax femtosecond laser (Carl Zeiss Meditec, Jena, Germany) and a matched group of 100 eyes

2015 Journal of Refractive Surgery

37. Treatment of Keratoconus With Advanced Corneal Crosslinking

Scheimflug camera and/or repeated subjective refraction and keratometry. A keratoconus diagnosis based on the Amsler-Krumeich grading and the "Total Deviation" KC quantification value from the "Belin-Ambrosio enhanced ectasia" measurements of the Pentacam Scheimpflug camera, and an altered red reflex and/or an irregular cornea seen as distortion of the keratometric mires. Minimum corneal thickness of 400 µm at the thinnest point after epithelial removal. 18-28 years of age No ocular abnormalities except (...) Treatment of Keratoconus With Advanced Corneal Crosslinking Treatment of Keratoconus With Advanced Corneal Crosslinking - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment of Keratoconus With Advanced

2015 Clinical Trials

38. Hyperosmolar Tears Induce Functional and Structural Alterations of Corneal Nerves: Electrophysiological and Anatomical Evidence Toward Neurotoxicity. (Full text)

that are strongly excited by corneal dessication ("dry response"), a response thought to trigger the lacrimation reflex. In the present study, we found that the dry responses of corneal dry-sensitive neurons were depressed or even completely abolished by hyperosmolar tears in a time- (30 minutes to 3 hours) and dose (450- to 1000-mOsm solutions)-dependent manner. Furthermore, eyes treated with hyperosmolar tears for 3 hours contained large numbers of morphologically abnormal (granular, fragmented (...) Hyperosmolar Tears Induce Functional and Structural Alterations of Corneal Nerves: Electrophysiological and Anatomical Evidence Toward Neurotoxicity. In an effort to elucidate possible neural mechanisms underlying diminished tearing in dry eye disease, this study sought to determine if hyperosmolar tears, a ubiquitous sign of dry eye disease, produce functional changes in corneal nerve responses to drying of the cornea and if these changes correlate with alterations in corneal nerve

2015 Investigative Ophthalmology & Visual Science PubMed

39. Changes in corneal aesthesiometry and the sub-basal nerve plexus in benign essential blepharospasm. (PubMed)

Changes in corneal aesthesiometry and the sub-basal nerve plexus in benign essential blepharospasm. The aetiology of blepharospasm remains unclear. There is evidence that the afferent pathway is important, but this area remains under-researched.To explore the hypothesis that the afferent arm of the blink reflex is abnormal in blepharospasm by assessing a range of measures of corneal sensory function.In this prospective case-control study, 21 patients with blepharospasm and 21 age-matched (...) and gender-matched controls completed the Ocular Surface Disease Index questionnaire and underwent the following assessments: tear osmolarity, Shirmer test, tear-film break up time, corneal and conjunctival vital staining, meibomian gland dysfunction, corneal aesthesiometry and confocal microscopy.Corneal sensitivity was significantly lower in patients with blepharospasm than in controls (right eyes p=0.009; left eyes p=0.009, paired t test). The median number of main nerve trunks was lower for patients

2015 British Journal of Ophthalmology

40. Transglutaminase binding fusion protein linked to SLPI reduced corneal inflammation and neovascularization. (Full text)

staining at 18 and 24 hours. In the remaining animals corneal opacity was studied and digital photographs were taken at day 7 before doing euthanasia. Eyes were processed for histology and immunofluorescence.Corneal ulcerated area was significantly lower in PF-MC treated animals compared to SLPI and buffer-treated animals at 18 hours and 24 hours postinjury. A clear cornea and fundus red reflex was only found among PF-MC treated animals. Histological analysis revealed a stratified corneal epithelium (...) Transglutaminase binding fusion protein linked to SLPI reduced corneal inflammation and neovascularization. To study the effect of topical administration of a fusion protein (PF-MC) made up of N-terminal portion of the protease inhibitor Trappin-2 (which is a substrate of transglutaminasa-2) and SLPI (protein with anti-inflammatory, anti-bacterial and anti-viral ability), in an animal model of corneal inflammation and angiogenesis.An alkali injury was produced with a filter paper of 3 mm with 1

2015 BMC Ophthalmology PubMed

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