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Corneal Reflex

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181. EFNS?ENS Guidelines on the diagnosis and management of disorders associated with dementia

limbs, usually of the limb‐kinetic type. During the evolution of the disease, postural and action tremor, limb dystonia, focal reflex myoclonus, postural instability and falls, alien hand‐like phenomenon, corticospinal signs, oculomotor and eyelid motor deficits and dysarthria develop in more than half of cases. CBD, the commonest cause of CBS, is a 4‐repeat tauopathy defined by unique neuropathological features including cortical atrophy, nigral degeneration, achromasia (swollen neurons (...) hallucinations . Genetic prion diseases Genetic prion diseases occurring in 10–15% of cases are caused by prion protein gene ( PRNP ) mutations, showing the patterns of autosomal‐dominant inheritance with incomplete penetrance. The disorders manifest as familial Creutzfeldt–Jakob disease (fCJD), Gerstmann–Sträussler–Scheinker disease (GSS) or fatal familial insomnia (FFI). Accidentally transmitted (iatrogenic) CJD has been related to corneal graft transplantation, contaminated human pituitary‐derived growth

2012 European Academy of Neurology

182. TearLab osmolarity system for diagnosing dry eye disease

, whereas grade 4 refers to severe and constant DED with potentially disabling symptoms. Severe symptoms can impair vision, limiting vision-related daily activities such as reading and driving. The complications of DED include conjunctivitis, keratitis (infection of the cornea) and corneal scarring. The condition is estimated to affect 15–33% of people aged over 65 years, and is about 50% more common in women than men (NICE clinical knowledge summary on dry eye syndrome; Lemp et al. 2012). DED is also (...) -and- conditions#notice-of-rights). Page 5 of 32Setting and intended use Setting and intended use The T earLab osmolarity system is intended to measure the osmolarity of tears to help diagnose DED, in conjunction with other tests and with clinical evaluation. T earLab Corporation recommends that the osmolarity test is done before any other tests, such as the fluorescein dye test, because they could stimulate the production of reflex tears (which differ from basal tears) and affect the value of the reading

2015 National Institute for Health and Clinical Excellence - Advice

183. Vegetative State 2.0

be present. The movements can vary from fast to quite slow. They can be almost constantly present, or rarely seen. 3) Automatic chewing (lips typically closed) and swallowing are frequently present. 4) Blinking is a common finding (including blinking while the lids are closed). The patient who has an essentially preserved brain stem, intact cranial nerves and end organs, will have preserved pupillary, corneal, oculocephalic, vestibulo-ocular, gag and cough reflexes. With brain stem or cranial nerve (...) for the imagery tasks could have elicited some type of cortical response independent of awareness, some kind of a very sophisticated knee-jerk reflex. Ropper suggested that instead of cuing the patients with “playing tennis” versus “relax”, Monti’s team should have asked patients “imagine playing tennis” and compared with “imagine not playing tennis”. Perhaps nothing in clinical medicine is as complex as the assessment of consciousness, thus Allan Ropper, Andrew Billings, and others(3)(13)(14)(15) all hold

2011 Clinical Correlations

184. Efficacy of stereotactic gamma knife surgery and microvascular decompression in the treatment of primary trigeminal neuralgia: a retrospective study of 220 cases from a single center (Full text)

significantly reduced compared with those of patients treated with GKS at the same postoperative time points (P<0.01). Patients treated with GKS had a significantly increased rate of loss of corneal reflex compared with patients treated with MVD (P=0.002).Both GKS and MVD are safe and effective first-line and adjunctive treatment options for patients with TN. The clinical outcomes of pain relief and reduction of pain recurrence were better with MVD. For GKS, this study showed that the optimal radiation

2016 Journal of pain research PubMed

185. Total Upper Eyelid Reconstruction with Modified Cutler-Beard Procedure Using Autogenous Auricular Cartilage (Full text)

% were included. Of these patients, those with lymph node involvement, distant metastasis, lower eyelid involvement, corneal infiltration or intra-orbital extension were excluded. FNAC was done in all the cases. Created defect was measured in mm (length and width) and later expressed in percentage. Pre and Post-operative measurement of Levator Palpebrae Superioris (LPS) was done. Pre and Post-operative measurement of Margin to Reflex Distance (MRD1) were also noted.Upper eyelid recreation

2016 Journal of clinical and diagnostic research : JCDR PubMed

186. Clinical Outcomes of Femtosecond Laser-assisted Pterygium Surgery (FLAPS)

pressures during suction application. Patients with amblyopia or strabismus or those who are at risk for developing strabismus postoperatively as determined by corneal light reflex and cover-uncover testing. Patients who are pregnant, lactating, of child-bearing potential and not practising a medically approved method of birth control, or planning to become pregnant during the course of the trial, and patients with other conditions associated with fluctuation of hormones that could lead to refractive (...) ) to be measured with a Snellen chart at 6 meters, then converted to logarithmic minimum angle of resolution unit to allow for averaging and statistical analysis Refraction [ Time Frame: Day 0, 7 and 1, 3, 6, 12 months ] Non-invasive non-contact measurement with autorefractor measured in spherical and cylindrical diopters Corneal Topography [ Time Frame: (Day 0, 7 and 1, 3, 6, 12 months) ] Non-invasive non-contact scan with OCULUS Pentacam, measurement of cylindrical diopters Eligibility Criteria Go

2016 Clinical Trials

187. Multicenter Neonatal Eye Disease Screening in China

School of Medicine. The multi-center network will be built with the collaboration of eight hospitals from different parts of China. Condition or disease Eye Disease Detailed Description: Studies reveal that ocular anomalies may also be found in healthy full-term babies. These abnormal ocular findings included subconjunctival haemorrhage, congenital microphthalmos, congenital corneal leukoma, posterior synechia, persistent pupillary membrane, congenital cataract, enlarged C/D ratio, retinal hamartoma (...) and timely treatment. All the neonates will undergo eye examination by using RetCam III. The external eye, pupillary light reflex, red reflex, opacity of refractive media, anterior chamber and posterior segments will be examined. The outcomes will be analyzed by a blinded specialist in order to discover serious congenital, hereditary and acquired diseases in the neonatal period of healthy newborns and to improve epidemiological information of neonatal ophthalmopathy. Neonatal ocular examination may play

2016 Clinical Trials

188. Two Different Surgical Methods of Blepharospasm

that facial nerve and trigeminal nerve combing can improve the clinical symptoms of the patients. Therefore, the investigators speculated that over activity were related to clinical symptoms and corneal reflex pathway of blepharospasm patients. Research content: the blepharospasm patients were randomly divided into two groups, prospective comparative analysis of two different surgical methods for the treatment of blepharospasm. One group of patients were performed facial nerve combing and microvascular (...) symptoms and corneal reflex pathway of blepharospasm patients. Research content: the blepharospasm patients were randomly divided into two groups, prospective comparative analysis of two different surgical methods for the treatment of blepharospasm. One group of patients were performed facial nerve combing and microvascular decompression, the other group of patients were performed facial nerve, trigeminal nerve combing with microvascular decompression, to observation of postoperative clinical

2016 Clinical Trials

189. Identification of Neurological Prognostic Markers of Cardiac Arrest Patients Alive on 3rd Day

of Neurology had proposed a decision algorithm for use in prognostication of comatose survivors published in 2006.Before the widespread use of therapeutic hypothermia (TH), predictor factors of neurological outcome were: serum neuron-specific enolase (NSE), N20 somatosensory-evoked potentials (SSEP), status epilepticus, pupil and corneal reflexes and Glasgow coma score motor response (GCS-M). Therapeutic hypothermia is recommended in the management of CA.It has been associated with improved outcome after (...) collected. The following prognostication factors were tested: neurological examination at day 3 and 7 including corneal and pupillary reflexes, GCS-M, status epilepticus, electro-encephalogram (EEG), SSEPs and NSE levels between day 2 and day 3. Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 130 participants Observational Model: Cohort Time Perspective: Retrospective Official Title: Neuron Specific Enolase and Glasgow Motor Score Remain Useful Tools

2016 Clinical Trials

190. Predictive Electrophysiological Score of the Neurological Prognosis Post Cardiac Arrest

. The American Academy of Neurology identifies accurate predictors of poor neurologic outcome (2): clinical examination findings such as no pupil response, no corneal reflexes, no motor response to stimulation and early myoclonus status epilepticus; biologic parameters like high neuron specific enolase (NSE) greater than 33 μg/L (3-4) and electrophysiologic results like flat electroencephalogram (EEG) or with burst suppression and Somatosensory evoked potentials (SEP) with no response to N20. Brain imaging (...) of hypothermia, warming was started at a rate of 0.2 ° C/hr; neuromuscular blocking agents were arrested at 35.5°C and sedation at 36.5°C. Neurological evaluation performed at 48 hours off sedation included a clinical evaluation (Glasgow score, myoclonus status, response to orders, motor response to stimulation, brain-stem reflexes). NSE was sampled between 48 and 72 H. EEGs were performed at Day-2, Day-3 and Day-5 off sedation and SEP at Day-5 off sedation. All EEGs were interpreted by two certified

2016 Clinical Trials

191. Comparison of the Clinical Effects of Two Tear Substitutes in Patients With Dry Eye Syndrome

Naturale Forte Tears Naturale Forte was applied to one eye of patients in this group Drug: Tears Naturale Forte the other eye of the participant recieved Tears Naturale Forte Other Name: DEXTRAN/HYPROMELLOSE/GLYCERIN Outcome Measures Go to Primary Outcome Measures : scale of Schirmer I test [ Time Frame: up to 3 months after tear substitutes apply ] scale of corneal fluorescein staining [ Time Frame: up to 3 months after tear substitutes apply ] scale of noninvasive tear breakup time [ Time Frame: up (...) the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 20 Years to 40 Years (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Minimum age of 20 years(range from 20 year to 25 years) The value of OSDI is over 12 NBUT is less 5 seconds Schirmer 1 test is less 10mm The basical lipid layer grade is 1-2 Exclusion Criteria: Any corneal,conjunctival, or eyelid

2016 Clinical Trials

192. Neurological Outcomes After In-Hospital Cardiac Arrest

score is classified according to the point. Good neurological outcome is defined as CPC 1-2 and poor is CPC 3-5. CPC score will be evaluated by neurological examination and the results of other exam. Neurological examination: Neurologist will perform directly until the point of CPC score 1 is confirmed. mental status: ACDU score, FOUR score and Glasgow Coma Scale brain stem reflex: Light reflexes by pupillometer(the NeurOptics® NPi™-100 (Neuroptics Inc., Irvine, CA, USA)) and corneal reflexes motor (...) )) and corneal reflexes motor status Responsive state: Medical Research Council grade Unresponsive state: motor response to painful stimuli) seizure evaluation: status myoclonus , seizure, status epilepticus The result of other examinations in accordance with medical treatment guideline will be evaluated as well. (e.g. Finding MRI of the brain, EEG, neuron specific enolase) CPC score [ Time Frame: 12 month after IHCA ] CPC score is the most universal index to assess neurological outcome following cardiac

2016 Clinical Trials

193. Multichannel Vestibular Implant Early Feasibility Study

. Preclinical studies have demonstrated that electrical stimulation of the vestibular nerve via a chronically implanted multichannel vestibular prosthesis can partially restore vestibular reflexes that maintain steady posture and vision. This pilot clinical feasibility study of a multichannel vestibular implant system will evaluate this approach in up to ten human subjects with bilateral vestibular deficiency due to gentamicin ototoxicity or other causes of inner ear dysfunction. Condition or disease (...) , and post-deactivation) Change in three-dimensional (3D) angular vestibulo-ocular reflex (VOR) gain [dimensionless] during ~150 deg/sec passive head impulse with modulated prosthetic input to assess the preliminary efficacy of the MVI [ Time Frame: through study completion, an average of 1 year, that is: in visits 0, 3-10 ] VOR gain (eye velocity / -head velocity) Secondary Outcome Measures : Consonant-vowel nucleus-consonant (CNC) speech recognition scores to assess the effects of MVI™ implantation

2016 Clinical Trials

194. Clinical Evaluation of An Approved Contact Lens

and evaluated over a period of 2 weeks. Device: Marketed Contact Lens Narafilcon A Outcome Measures Go to Primary Outcome Measures : Tear Film Osmolarity [ Time Frame: 2-Week Follow-up ] Tear film osmolarity was measured in each subject eye using the TearLab Osmolarity system. The instrument was placed gently into the lower lid temporal tear minuscus without simulating reflex tearing Secondary Outcome Measures : Tear Film Osmolarity [ Time Frame: 1-Week Follow-up ] Tear film osmolarity was measured in each (...) subject eye using the TearLab Osmolarity system. The instrument was placed gently into the lower lid temporal tear minuscus without simulating reflex tearing. Tear Film PH [ Time Frame: 1-Week Follow-up ] Tear Film PH was measured using a 1mm Microglass electrode (Thermo Scientific Orion 9810BN) placed gently in lower temporal tear meniscus of non-Schirmer eye without simulating reflex tearing. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate

2016 Clinical Trials

195. Circulatory collapse, right ventricular dilatation, and alveolar dead space: A triad for the rapid diagnosis of massive pulmonary embolism. (PubMed)

to our emergency department, arriving minimally responsive with undetectable blood pressure but having positive corneal reflexes and bradycardia with wide QRS. The trachea was intubated and goal-directed echocardiography revealed marked right ventricular dilatation with septal flattening. The arterial PCO2 was 40mmHg with an end-tidal PCO2 of 8mmHg, revealing a large alveolar dead space. Persistent hypotension, bradycardia, and fading alertness despite epinephrine and norepinephrine infusions

2016 American Journal of Emergency Medicine

196. Melanopsin-mediated post-illumination pupil response in the peripheral retina. (Full text)

Melanopsin-mediated post-illumination pupil response in the peripheral retina. Intrinsically photosensitive retinal ganglion cells (ipRGCs) regulate pupil size by integrating extrinsic rod and cone signals with intrinsic melanopsin-mediated phototransduction. Light adapted pupil diameter is determined by the corneal flux density (CFD), and for central visual field stimulation the melanopsin-mediated post-illumination pupil response (PIPR) follows this same CFD relationship. Rods, cones (...) , and ipRGCs vary in size, density, and distribution across the retina, but how these differences affect the amplitude and timing of the extrinsic and intrinsic pupil light reflex in the central and peripheral retina is unknown. We determined the relationship between stimulus area and photon flux with stimuli constant for CFD, irradiance, or area at central (0°) and peripheral (20°) eccentricities with high and low melanopsin excitation. We show that the pupil constriction amplitude was similar at both

2016 Journal of vision PubMed

197. Comparison of Clinical Outcomes in Ziemer Femtosecond Versus Conventional Phacoemulsification Surgery

with anterior segment pathology. Patients with any corneal abnormality Patients with any progressive retinal disease or subjects with a history or evidence of retinal vascular occlusion and/or hypercoagulability, because of the risks associated with high pressures during suction application. Patients with amblyopia or strabismus or those who are at risk for developing strabismus postoperatively as determined by corneal light reflex and cover-uncover testing. Patients who are pregnant, lactating, of child (...) Measures : Cumulative dissipated energy (CDE) (nJ) [ Time Frame: 12 months ] Secondary Outcome Measures : Best corrected distance visual acuity (snellen) [ Time Frame: 12 months ] Refraction (diopters) [ Time Frame: 12 months ] Corneal endothelial count [ Time Frame: 12 months ] Anterior chamber inflammation (by flaremeter) [ Time Frame: 12 months ] Effective intraocular lens position (UBM) [ Time Frame: 12 months ] Intraocular pressure (mmHg) [ Time Frame: 12 months ] Patient surgery experiences

2016 Clinical Trials

198. Ten Years of Results of Modified Frontalis Muscle Transfer for the Correction of Blepharoptosis (Full text)

of modification, preoperative and postoperative values of the marginal distance reflex 1 (MRD1), the corneal exposure area, and the decrease in eyebrow height were compared between the two groups.In group A, patients showed an improvement of 1.19 mm in the MRD1, a 6.31% improvement in the corneal exposure area, and a 7.82 mm decrease in eyebrow height. In group B, patients showed an improvement of 2.17 mm in the MRD1, an 8.39% improvement in the corneal exposure area, and an 11.54 mm decrease in eyebrow

2016 Archives of plastic surgery PubMed

199. Development of an In Vitro Ocular Platform to Test Contact Lenses (Full text)

Development of an In Vitro Ocular Platform to Test Contact Lenses Currently, in vitro evaluations of contact lenses (CLs) for drug delivery are typically performed in large volume vials, which fail to mimic physiological tear volumes. The traditional model also lacks the natural tear flow component and the blinking reflex, both of which are defining factors of the ocular environment. The development of a novel model is described in this study, which consists of a unique 2-piece design, eyeball (...) and eyelid piece, capable of mimicking physiological tear volume. The models are created from 3-D printed molds (Polytetrafluoroethylene or Teflon molds), which can be used to generate eye models from various polymers, such as polydimethylsiloxane (PDMS) and agar. Further modifications to the eye pieces, such as the integration of an explanted human or animal cornea or human corneal construct, will permit for more complex in vitro ocular studies. A commercial microfluidic syringe pump is integrated

2016 Journal of visualized experiments : JoVE PubMed

200. Bell's Palsy

MRI Identifies central causes (Schwannoma, , meningioma and ) MRI offers prognostic information based on nerve contrast enhancement Indications Suspected central cause (see Red Flags above) Persistent or progressive peripheral Facial Nerve Palsy lasting >2 months Facial twitching or spasm XV. Management: Loss of Blink Reflex Rewetting the eye Frequent use of preservative-free artificial tears (every 15 to 30 minutes) Refresh PM ointment six times daily Protective glasses with side pieces Use (...) :// ) Definition (MSH) A syndrome characterized by the acute onset of unilateral FACIAL PARALYSIS which progresses over a 2-5 day period. Weakness of the orbicularis oculi muscle and resulting incomplete eye closure may be associated with corneal injury. Pain behind the ear often precedes the onset of paralysis. This condition may be associated with HERPESVIRUS 1, HUMAN infection of the facial nerve. (Adams et al., Principles of Neurology, 6th ed, p1376) Concepts Disease or Syndrome ( T047 ) MSH

2018 FP Notebook

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