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Corneal Reflex

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181. Inhaled Nitric Oxide After Out-of-Hospital Cardiac Arrest

Inclusion Criteria: Intubated and comatose adult (>18 yo) resuscitated from out-of-hospital cardiac arrest (OHCA)* *Cardiac arrest within an emergency department or outpatient medical center will be included). OHCA includes Emergency Medical Service (EMS) witnessed cardiac arrest. Return of spontaneous circulation (ROSC) within 40 min of CPR initiation Full Outline of Unresponsiveness (FOUR) Brainstem score ≥ 2 (i.e. patient must have pupil OR corneal reflex at the time of ED presentation or within 1h

2017 Clinical Trials

182. Multifocal Chromatic Pupilloperimetry in Patients With Pseudotumor Cerebri and Healthy Subjects.

cloudy corneas. Any condition preventing accurate measurement or examination of the pupil. PTC patients Any other neurologic or ophthalmic disease other than PTC Use of any topical or systemic medications that could adversely influence pupillary reflex Intolerance to gonioscopy, slit lamp examination, Goldmann applanation tonometry or other schedule study procedure. Mental impairment or instability such as that informed consent may not be obtained or compliance with tester instructions is unlikely (...) typical for PTC Exclusion Criteria: Healthy subjects History of past (last 3 months) or present ocular disease or ocular surgery Use of any topical or systemic medications that could adversely influence pupillary reflex Intolerance to gonioscopy, slit lamp examination, Goldmann applanation tonometry or other schedule study procedure. Mental impairment or instability such as that informed consent may not be obtained or compliance with tester instructions is unlikely. Visual media opacity including

2017 Clinical Trials

183. Effects of Two Tear Substitutes in Patients With Dry Eye Syndrome

is 1-2 Exclusion Criteria: Any corneal,conjunctival, or eyelid abnormalities; conjunctivitis; current ocular infection; photophobia that may cause reflex tearing or difficulty in evaluating the patien 's lipid layer; Known allergic sensitivity to any of the ingredients in Liposic or Tears Naturale Forte Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information (...) of the participant recieved Tears Naturale Forte Other Name: DEXTRAN/HYPROMELLOSE/GLYCERIN Outcome Measures Go to Primary Outcome Measures : scale of Schirmer I test [ Time Frame: up to 3 months after tear substitutes apply ] scale of corneal fluorescein staining [ Time Frame: up to 3 months after tear substitutes apply ] scale of noninvasive tear breakup time [ Time Frame: up to 3 months after tear substitutes apply ] scale of tear meniscus height [ Time Frame: up to 3 months after tear substitutes apply

2017 Clinical Trials

184. Comparison Between Different Surgical Approaches for the Treatment of INVOLUTIONAL PTOSIS

or mullerectomy Outcome Measures Go to Primary Outcome Measures : MRD1 [ Time Frame: 6 months ] Distance in millimeters between corneal light reflex and upper eyelid margin surgery duration [ Time Frame: 3 hours ] Time from first incision to last suture (in minutes) Levator function [ Time Frame: 6 months ] change (in millimeters) in upper eyelid position from downgaze to maximal upgaze Secondary Outcome Measures : Need for additional eyelid surgery [ Time Frame: 6 months ] Any need for oculoplastic

2017 Clinical Trials

185. A Study to Evaluate the Raindrop Near Vision Inlay Under Flap or Within Pocket

for corneal staining Grade 3 or higher, recurrent corneal erosion or severe basement membrane disease, and pterygium extending onto the cornea. 1.1.12 Patients with ophthalmoscopic/topographic signs of keratoconus or those who are keratoconus suspect. 1.1.13 Patients with history of Herpes zoster or Herpes simplex keratitis. 1.1.14 Patients with any progressive retinal disease or patients with a history or evidence of retinal vascular occlusion and/or hypercoagulability, because of the risks associated (...) with high pressures during suction application. 1.1.15 Patients with known history of steroid-responsive intraocular pressure increases, glaucoma, preoperative IOP > 21 mm Hg, or are otherwise suspected of having glaucoma. 1.1.16 Patients with amblyopia or strabismus or those who are at risk for developing strabismus postoperatively as determined by corneal light reflex and cover-uncover testing. 1.1.17 Patients with diabetic retinopathy, collagen, vascular, diagnosed autoimmune disease (e.g., lupus

2017 Clinical Trials

186. Development of a Chromatic Pupillography Protocol for the First Gene Therapy Trial in Patients With CNGA3-Linked Achromatopsia. Full Text available with Trip Pro

the pupillary light reflex parameters and to create the final protocol. In the individual protocols, various stimulus parameters (i.e., intensity, duration, wavelength, adaptation states) were applied to evaluate the impact of these stimuli on the pupillary response in untreated ACHM patients.In the light-adapted conditions, CNGA3-ACHM patients showed significantly reduced maximal amplitudes compared with the control group when using a 1-second high intensity (28-lux corneal illumination) blue or red (...) stimulus (P < 0.005). In the dark-adapted conditions, CNGA3-ACHM patients unexpectedly revealed significantly increased maximal amplitudes when stimulating with red (1 second) or blue (4 ms and 1 second) stimuli of low intensity (0.01-lux corneal illumination; P < 0.05). Pupil responses of CNGA3-ACHM patients after high intensity (28 lux) red and blue 1-second stimuli were within the normal range.Chromatic pupillography demonstrated significant reduced pupil responses to stimuli addressing primarily

2017 Investigative Ophthalmology & Visual Science

187. A prospective multicentre randomized placebo-controlled superiority trial in patients with suspected bacterial endophthalmitis after cataract surgery on the adjuvant use of intravitreal dexamethasone to intravitreal antibiotics. Full Text available with Trip Pro

, corneal oedema, the absence of a red fundus reflex on presentation, LP on presentation and culture of virulent pathogens from biopsy were statistically significantly associated with an unfavourable visual outcome.Intravitreal dexamethasone without preservatives as an adjuvant to intravitreal antibiotics does not improve visual acuity (VA) in patients treated for suspected bacterial endophthalmitis after cataract surgery.© 2017 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley

2017 Acta ophthalmologica Controlled trial quality: predicted high

188. Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy. Full Text available with Trip Pro

Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy. Impaired rate-dependent depression (RDD) of the Hoffman reflex is associated with reduced dorsal spinal cord potassium chloride cotransporter expression and impaired spinal γ-aminobutyric acid type A receptor function, indicative of spinal inhibitory dysfunction. We have investigated the pathogenesis of impaired RDD in diabetic rodents exhibiting features of painful neuropathy and the translational potential (...) of this marker of spinal inhibitory dysfunction in human painful diabetic neuropathy. Impaired RDD and allodynia were present in type 1 and type 2 diabetic rats but not in rats with type 1 diabetes receiving insulin supplementation that did not restore normoglycemia. Impaired RDD in diabetic rats was rapidly normalized by spinal delivery of duloxetine acting via 5-hydroxytryptamine type 2A receptors and temporally coincident with the alleviation of allodynia. Deficits in RDD and corneal nerve density were

2017 Diabetes

189. Small Incision Lenticule Extraction (SMILE) for Hyperopia: Optical Zone Centration. (Abstract)

) and astigmatism up to 6.00 D. For SMILE, the optical zone was between 6.3 and 6.7 mm, with a 2-mm transition zone. Two LASIK control groups (6.5- and 7-mm optical zone) were generated matched for spherical equivalent treated. In SMILE, the corneal vertex of the coaxially fixating eye was aligned with the vertex of the curved contact glass. In LASIK, the treatment was centered on the coaxially sighted corneal light reflex (first Purkinje image) with the contralateral eye (Seiler method). A tangential (...) (instantaneous) curvature preoperative to 3 months postoperative difference map was generated for each eye. A fixed grid and set of concentric circles were superimposed on the difference map to measure the offset between the optical zone center and corneal vertex (0,0), and vector analysis was used for comparative analysis.Mean attempted spherical equivalent was +5.61 ± 0.96 D (range: +3.20 to +6.50 D) and mean cylinder was -0.96 ± 0.62 D (range: 0.00 to -2.75 D) in the SMILE group. Mean age was 29 ± 7 years

2017 Journal of Refractive Surgery

190. Outcome after Hunt and Hess Grade V subarachnoid hemorrhage: a comparison of pre-coiling era (1980-1995) versus post-ISAT era (2005-2014). (Abstract)

treatment resulted in a significant improvement in survival rate (NNT = 2) and favorable outcome (NNT = 3 for mRS score of 0-3) for comatose patients with Hunt and Hess Grade V SAH compared with the earlier period. Independent predictors for favorable outcome were younger age and bilateral intact corneal reflexes. Despite a high rate of cerebral infarction (65%) in the current period, 29.5% of the patients who received treatment for their aneurysms during the current era (2005-2014) had a favorable

2017 Journal of Neurosurgery

191. External validation of prediction models for time to death in potential donors after circulatory death. Full Text available with Trip Pro

used the data of 92 potential cDCD donors. Multivariable regression analysis demonstrated that absent cough-, corneal reflex, lower morphine dosage, and midazolam use were significantly associated with death within 60 minutes (area under the curve [AUC] 0.89; 95% confidenence interval [CI] 0.87-0.91). External validation of the logistic regression models of de Groot et al (AUC 0.86; 95% CI 0.77-0.95), Wind et al (AUC 0.62; 95% CI 0.49-0.76), Davila et al (AUC 0.80; 95% CI 0.708-0.901) and the Cox

2017 American Journal of Transplantation

192. Quantification of rat supraglottic laryngeal sensation threshold. (Abstract)

, and 3) determine the ideal depth of anesthesia.Animal study.Rats were induced with ketamine/xylazine. The level of anesthesia was monitored by spontaneous glottic closure and corneal reflex testing. Air puffs were delivered to the epiglottis, arytenoid, and piriform sinus at varied pressures with pulse time kept constant. Sensation thresholds were determined by direct visualization of the larynx using a binocular microscope. Topical lidocaine was then applied to the larynx and ST was determined (...) . Trials were repeated in a small subset of animals.Twenty-six trials were performed in 14 rats. Mean STs were 39 ± 9.7 mm Hg at the epiglottis, 48.8 ± 10.5 at the arytenoid, and not detectable at the pyriform sinus. Repeated trials demonstrated consistent results. Lidocaine effectively ablated the LAR in each trial. The LAR was difficult to induce while corneal reflex was absent and was difficult to distinguish from spontaneous glottic closures while under lighter sedation.Air pulse stimulation

2017 Laryngoscope

193. Electroencephalography Predicts Poor and Good Outcomes After Cardiac Arrest: A Two-Center Study. Full Text available with Trip Pro

than 70% positive predictive value for good outcome; reactivity (80.4%; 95% CI, 75.9-84.4%) and motor response (80.1%; 95% CI, 75.6-84.1%) had highest accuracy. Early benign electroencephalography heralded good outcome in 86.2% (95% CI, 79.8-91.1%). False positive rates for mortality were less than 5% for epileptiform or nonreactive early electroencephalography, nonreactive late electroencephalography, absent somatosensory-evoked potential, absent pupillary or corneal reflexes, presence

2017 Critical Care Medicine

194. Epidermoid cysts of the cavernous sinus: clinical features, surgical outcomes, and literature review. Full Text available with Trip Pro

with CS epidermoid cysts that had been surgically treated at the authors' hospital between 2001 and 2016. The patients' medical records, imaging data, and follow-up outcomes were retrospectively analyzed. The related literature from the past 40 years (18 articles, 20 patients) was also evaluated.The most common chief complaints were facial numbness or hypesthesia (64.5%), absent corneal reflex (45.2%), and abducens or oculomotor nerve deficit (35.5%). On MRI, 51.6% of the epidermoid cysts showed low

2017 Journal of Neurosurgery

195. Principles of pharmacology in the eye Full Text available with Trip Pro

to many physical and biochemical barriers including the pre-corneal tear film, the structure and biophysiological properties of the cornea, the limited volume that can be accommodated by the cul-de-sac, the lacrimal drainage system and reflex tearing. The tissue layers of the cornea and conjunctiva are further key factors that act to restrict drug delivery. Using carriers that enhance viscosity or bind to the ocular surface increases bioavailability. Matching the pH and polarity of drug molecules

2017 British journal of pharmacology

196. Ophthalmic manifestations in Rothmund–Thomson syndrome: Case report and review of literature Full Text available with Trip Pro

Ophthalmic manifestations in Rothmund–Thomson syndrome: Case report and review of literature A 24-year-old male patient presented to us with diminution of vision in both eyes with watering and photophobia for the past 8 years. General physical examination showed short stature and poikiloderma. Ocular findings include photophobia with reflex tearing, dry eye, cicatricial ectropion, symblepharon approaching pupillary area of cornea, and multiple superficial punctuate erosions on the cornea (...) . Both eyelids showed scanty meibomian glands on infrared meibography. The rest of the anterior and posterior segment was normal. The patient was treated with topical lubricants which reduced photophobia and corneal erosions. He then underwent symblepharon release with buccal mucosal grafting, which improved ectropion. Patient improved symptomatically with reduction of photophobia and improvement in vision as well.

2017 Indian journal of ophthalmology

197. TFOS DEWS II pain and sensation report Full Text available with Trip Pro

and reflex blinking. ViVc ocular neurons project to brain regions that control lacrimation and spontaneous blinking and to the sensory thalamus. Secretion of the main lacrimal gland is regulated dominantly by autonomic parasympathetic nerves, reflexly activated by eye surface sensory nerves. These also evoke goblet cell secretion through unidentified efferent fibers. Neural pathways involved in the regulation of meibomian gland secretion or mucin release have not been identified. In dry eye disease (...) of molecular, structural and functional disturbances in ocular sensory pathways ultimately leads to dysestesias and neuropathic pain referred to the eye surface. Pain can be assessed with a variety of questionaires while the status of corneal nerves is evaluated with esthesiometry and with in vivo confocal microscopy.Copyright © 2017 Elsevier Inc. All rights reserved.

2017 The ocular surface

198. Riley-Day Syndrome in a Hispanic Infant of Non-Jewish Ashkenazi Descent Full Text available with Trip Pro

of strabismus, absence of fungiform papillae, feeding difficulty, gastroesophageal reflux and episodes of self-mutilation. Deep tendon reflexes were depressed, the blinking rate and corneal reflex were diminished as well and corneas were opaque due to corneal erosions. Reduced lacrimal production was confirmed by the Schirmer test. Eye drops were recommended every 2-3 hours for corneal erosion and the patient was referred to the genetics department for further diagnostic confirmation.

2017 Journal of clinical and diagnostic research : JCDR

199. Early predictors of poor outcome after out-of-hospital cardiac arrest Full Text available with Trip Pro

predictive of a poor outcome (CPC 3-5). On the basis of these factors, a risk score for poor outcome was constructed.We identified ten independent predictors of a poor outcome: older age, cardiac arrest occurring at home, initial rhythm other than ventricular fibrillation/tachycardia, longer duration of no flow, longer duration of low flow, administration of adrenaline, bilateral absence of corneal and pupillary reflexes, Glasgow Coma Scale motor response 1, lower pH and a partial pressure of carbon

2017 Critical Care

200. The Preferential Impairment of Pupil Constriction Stimulated by Blue Light in Patients with Type 2 Diabetes without Autonomic Neuropathy Full Text available with Trip Pro

The Preferential Impairment of Pupil Constriction Stimulated by Blue Light in Patients with Type 2 Diabetes without Autonomic Neuropathy The main aim of the present paper is to examine whether the pupillary light reflex (PLR) mediated by intrinsically photosensitive retinal ganglion cells (ipRGCs) is impaired in type 2 diabetic patients. One hundred and three diabetic patients without diabetic autonomic neuropathy (DAN) and 42 age-matched controls underwent a series of detailed neurological (...) examinations. The patients were stratified into three groups: stage I, no neuropathy; stage II, asymptomatic neuropathy; stage III, symptomatic but without DAN. The PLR to 470 and 635 nm light at 20 cd/m2 was recorded. Small fiber neuropathy was assessed by corneal confocal microscopy and quantifying corneal nerve fiber (CNF) morphology. The 470 nm light induced a stronger and faster PLR than did 635 nm light in all subjects. The PLR to both lights was impaired equally across all of the diabetic subgroups

2017 Journal of diabetes research

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