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Corneal Ulcer

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1. Cenegermin (Oxervate) - for the treatment of moderate (persistent epithelial defect) or severe (corneal ulcer) neurotrophic keratitis in adults

Cenegermin (Oxervate) - for the treatment of moderate (persistent epithelial defect) or severe (corneal ulcer) neurotrophic keratitis in adults Search Page - Drug and Health Product Register Language selection Search and menus Search Search website Search Topics menu You are here: Summary Basis of Decision - - Health Canada Expand all Summary Basis of Decision (SBD) for Contact: Summary Basis of Decision (SBD) documents provide information related to the original authorization of a product

2019 Health Canada - Drug and Health Product Register

3. Cenegermin (Oxervate) - Treatment of moderate (persistent epithelial defect) or severe (corneal ulcer) neurotrophic keratitis in adults

Cenegermin (Oxervate) - Treatment of moderate (persistent epithelial defect) or severe (corneal ulcer) neurotrophic keratitis in adults Published 08 October 2018 . Statement of advice SMC2124 cenegermin 20micrograms/ml eye drops, solution (Oxervate®) Dompé UK Ltd In confidence 7 September 2018 ADVICE: in the absence of a submission from the holder of the marketing authorisation cenegermin (Oxervate®) is not recommended for use within NHSScotland. Indication under review: Treatment of moderate (...) (persistent epithelial defect) or severe (corneal ulcer) neurotrophic keratitis in adults. The holder of the marketing authorisation has not made a submission to SMC regarding this product in this indication. As a result we cannot recommend its use within NHSScotland. Advice context: No part of this advice may be used without the whole of the advice being quoted in full. This advice represents the view of the Scottish Medicines Consortium and was arrived at after careful consideration and evaluation

2018 Scottish Medicines Consortium

4. Individualized penetrating keratoplasty using edge-trimmed glycerol-preserved donor corneas for perforated corneal ulcers. Full Text available with Trip Pro

Individualized penetrating keratoplasty using edge-trimmed glycerol-preserved donor corneas for perforated corneal ulcers. To report a surgical technique and the surgical outcomes of individualized penetrating keratoplasty (PK) using edge-trimmed glycerol-preserved donor corneas for perforated corneal ulcers.Fourteen perforated eyes from 14 patients who underwent individualized PK using edge-trimmed glycerol-preserved donor corneas, were included in the retrospective study. The perforations (...) were mainly 1-2 mm in size except for one that was 2.5 × 4 mm. Three patients were treated with PK; one patient was treated with PK and a conjunctival flap; ten patients who had large ulcer areas were treated with PK combined with lamellar keratoplasty (LK). Donor corneas were preserved in sterile pure glycerol at - 80 °C. Corneal grafts were specially edge-trimmed to match the perforation, and then sutured onto the recipient bed avoiding the visual axis.All 14 patients recovered anatomical

2019 BMC Ophthalmology

5. Resorbable and running suture for stable fixation of amniotic membrane multilayers: A useful modification in deep or perforating sterile corneal ulcers Full Text available with Trip Pro

Resorbable and running suture for stable fixation of amniotic membrane multilayers: A useful modification in deep or perforating sterile corneal ulcers To present a modified technique for secure tightening and fixing of multilayer amniotic membranes in deep or perforating corneal ulcers.The modified procedure for application and fixation of multilayer amniotic membranes is retrospectively described step by step, and the results of three patients treated with this technique were retrospectively (...) remained stable throughout the 3- to 5-month follow-up period. This modified technique represents a very useful auxiliary means of treating deep or perforating non-infectious corneal ulcers.

2018 American journal of ophthalmology case reports

6. Changes in interleukin-6 tear concentration and clinical outcome in moderate-to-severe bacterial corneal ulcers after corneal collagen cross-linking Full Text available with Trip Pro

Changes in interleukin-6 tear concentration and clinical outcome in moderate-to-severe bacterial corneal ulcers after corneal collagen cross-linking We aimed to evaluate interleukin-6 (IL-6) tear concentration and clinical outcome in patients with moderate-to-severe bacterial corneal ulcers post corneal collagen cross-linking (CXL) therapy. This pre-post designed study involving 21 moderate-to-severe corneal ulcer patients who underwent CXL therapy. Patients with infectious corneal ulcer were (...) given CXL therapy as adjunctive treatment after 5d of broadspectrum antibiotic treatment. Patients with moderate to severe infectious bacterial corneal ulcers were included in this study. Tear sampling was performed before CXL therapy, using sterile Schimer paper from conjunctival inferior fornix. CXL therapy was performed in accordance with the CXL Dresden protocol. Data recording and tear sampling were then performed at day 1 and day 7 after CXL therapy. Data recording included, presence

2018 International journal of ophthalmology

7. Colocalization of Galectin-3 With CD147 Is Associated With Increased Gelatinolytic Activity in Ulcerating Human Corneas. Full Text available with Trip Pro

and the presence of gelatinolytic activity.This was an observational case series involving donor tissue from 13 patients with active corneal ulceration and 6 control corneas. Fixed-frozen sections of the corneas were processed to localize galectin-3 and CD147 by immunofluorescence microscopy. Gelatinolytic activity was detected by in situ zymography.Tissue from patients with active corneal ulceration showed a greater galectin-3 immunoreactivity in basal epithelia and stroma compared with controls (...) . Immunofluorescence grading scores revealed increased colocalization of galectin-3 and CD147 in corneal ulcers at the epithelial-stromal junction and within fibroblasts. Quantitative analysis using the Manders' colocalization coefficient demonstrated significant overlap in corneas from patients with ulcerative keratitis (M1 = 0.29; M2 = 0.22) as opposed to control corneas (M1 = 0.01, P < 0.01; M2 = 0.02, P < 0.05). In these experiments, there was a significant positive correlation between the degree of galectin-3

2018 Investigative Ophthalmology & Visual Science

8. Modified ulcer debridement in the treatment of the superficial fungal infection of the cornea Full Text available with Trip Pro

Modified ulcer debridement in the treatment of the superficial fungal infection of the cornea To evaluate the efficacy of modified corneal ulcer debridement in superficial fungal keratitis unresponsive to medications.A total of 209 patients (209 eyes) with fungal keratitis, involving no more than 50% of the stromal depth and not responding to antifungal agents for 2wk, were recruited in this retrospective, noncomparative study. The patients were treated with modified corneal ulcer debridement (...) with preoperative hypopyon (P=0.036) and ever using steroid (P=0.025).Modified surgical debridement is a simple and effective method for the treatment of superficial fungal infection of the cornea, with improved visual acuity and no recurrence. Such an intervention in time can rapidly control fungal infection and largely shorten corneal ulcer healing time.

2018 International journal of ophthalmology

9. A study protocol for a multicentre randomised clinical trial evaluating the safety and feasibility of a bioengineered human allogeneic nanostructured anterior cornea in patients with advanced corneal trophic ulcers refractory to conventional treatment. Full Text available with Trip Pro

A study protocol for a multicentre randomised clinical trial evaluating the safety and feasibility of a bioengineered human allogeneic nanostructured anterior cornea in patients with advanced corneal trophic ulcers refractory to conventional treatment. There is a need to find alternatives to the use of human donor corneas in transplants because of the limited availability of donor organs, the incidence of graft complications, as well as the inability to successfully perform corneal transplant (...) in patients presenting limbal deficiency, neo-vascularized or thin corneas, etc. We have designed a clinical trial to test a nanostructured fibrin-agarose corneal substitute combining allogeneic cells that mimics the anterior human native cornea in terms of optical, mechanical and biological behaviour.This is a phase I-II, randomised, controlled, open-label clinical trial, currently ongoing in ten Spanish hospitals, to evaluate the safety and feasibility, as well as clinical efficacy evidence

2017 BMJ open Controlled trial quality: uncertain

10. Severe corneal ulcer with progression to endophthalmitis and high-grade bacteremia Full Text available with Trip Pro

Severe corneal ulcer with progression to endophthalmitis and high-grade bacteremia Bacterial sepsis is a common consequence of many infectious processes. Here, we describe a case of a woman with a corneal ulcer who went on to develop group B streptococcal (GBS) endophthalmitis, bacteremia, and eventual loss of the eye.A previously healthy, immunocompetent, middle aged, contact lens wearing female who, after freshwater boating in her contact lenses, developed a red, painful eye. She

2017 American journal of ophthalmology case reports

11. A case report of infectious scleritis with corneal ulcer caused by Scedosporium aurantiacum. Full Text available with Trip Pro

A case report of infectious scleritis with corneal ulcer caused by Scedosporium aurantiacum. Scedosporium species is rare pathogen of ocular infection. The accurate diagnosis is delaying in many cases and the clinical prognosis is poor due to its resistance to antifungal agents. This report describes a patient with infectious scleritis and corneal ulcer caused by Scedosporium auranticum infection who required enucleation to control the infection.A 70-year-old woman visited our clinic after (...) experiencing ocular discomfort in her right eye for 4 days after minor ocular trauma, with soil exposure.Scedosporium species was isolated from a culture of corneal tissue, Scedosporium aurantiacum was identified in a culture of necrotic tissue.She was started on treatment with antifungal agents, including topical amphotericin B and systemic fluconazole, but her ocular condition did not improve. Although the lesion showed temporary improvement, ocular pain and corneal ulcer recurred 3 months later

2019 Medicine

12. Severe congenital bilateral corneal ulceration due to Wolf-Hirschhorn syndrome: a case-report and review of the ophthalmic literature. (Abstract)

Severe congenital bilateral corneal ulceration due to Wolf-Hirschhorn syndrome: a case-report and review of the ophthalmic literature. A newborn boy with genetically confirmed Wolf-Hirschhorn syndrome presented with severe bilateral corneal ulceration that required emergency surgical tarsorrhaphies and permanent lower punctal occlusion. The patient healed completely, with no recurrence over 18 months of follow-up.Copyright © 2019 American Association for Pediatric Ophthalmology and Strabismus

2019 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

13. Efficacy and Safety of Amphotericin B with Autologous Serum for Fungal Corneal Ulcer. Full Text available with Trip Pro

Efficacy and Safety of Amphotericin B with Autologous Serum for Fungal Corneal Ulcer. To observe the clinical efficacy and safety of injection therapy of amphotericin B combined with autologous serum in the treatment of fungal corneal ulcer.An experimental study.Department of Ophthalmology, Jinan Second People's Hospital, Shandong Province, China, from July 2013 to June 2017.Patients diagnosed with monocular fungal corneal ulcer were divided randomly into observation group and control group, 48 (...) cases in each group. Control group was treated with amphotericin B alone. Observation group was treated with autologous serum injection on the basis of the control group treatment. The improvement time of clinical symptoms such as hypopyon, corneal ulcer, foreign body sensation and photophobia were observed in two groups. The clinical efficacy and adverse reactions were compared between the two groups.The total effective rate of the observation group was higher than that of the control group (p

2019 Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Controlled trial quality: uncertain

14. Visual impairment in fungal versus bacterial corneal ulcers four years after successful antimicrobial treatment. (Abstract)

Visual impairment in fungal versus bacterial corneal ulcers four years after successful antimicrobial treatment. To compare longitudinal visual acuity outcomes of fungal corneal ulcers with those of bacterial ulcers.Prospective cohort study SETTING: Tertiary eye hospital in South India STUDY POPULATION: 100 individuals who had been diagnosed four years prior with either fungal or bacterial keratitis and had been enrolled in one of two concurrent randomized trials, out of 152 consecutive (...) and 10 (20.0%) individuals in the bacterial group. Median BSCVA in the affected eye at the 4-year visit was similar in the fungal and bacterial groups (Snellen equivalent 20/32 for each), though vision worse than 20/400 was more common in the fungal ulcer group after spectacle correction (OR 4.19, 95%CI 1.11 to 15.8) and contact lens correction (OR 5.74, 95%CI 1.37-24.1).In this South Indian population with a previous episode of fungal or bacterial keratitis, correctable bilateral visual impairment

2019 American Journal of Ophthalmology

15. Implantation of a corneal graft-keratoprosthesis for severe corneal opacity in wet blinking eyes

in specialist centres by surgeons experienced in the technique; long-term follow-up should be carried out by an experienced multidisciplinary team. 2 2 Indications and current treatments Indications and current treatments 2.1 Injury or disease of the cornea can make it opaque, stopping light from entering the eye and resulting in loss of vision. Some severe corneal diseases can also affect the eye's blink and tear mechanisms. Corneal injuries can be caused by direct trauma, including surgery, as well (...) as chemical or thermal burns. Diseases that can cause corneal opacity include autoimmune diseases, bullous keratopathy, keratoconus, keratitis and corneal stromal dystrophies. 2.2 The standard treatment for significant corneal opacity is a corneal transplant (penetrating keratoplasty). Penetrating keratoplasty removes the opaque cornea using a trephine, replacing it with a donor cornea. Some patients cannot have a standard corneal transplant for reasons including: disease severity; severe involvement

2015 National Institute for Health and Clinical Excellence - Interventional Procedures

16. Epithelial basement membrane injury and regeneration modulates corneal fibrosis after pseudomonas corneal ulcers in rabbits Full Text available with Trip Pro

Epithelial basement membrane injury and regeneration modulates corneal fibrosis after pseudomonas corneal ulcers in rabbits The purpose of this study was to investigate whether myofibroblast-related fibrosis (scarring) after microbial keratitis was modulated by the epithelial basement membrane (EBM) injury and regeneration. Rabbits were infected with Pseudomonas aeruginosa after epithelial scrape injury and the resultant severe keratitis was treated with topical tobramycin. Corneas were (...) analyzed from one to four months after keratitis with slit lamp photos, immunohistochemistry for alpha-smooth muscle actin (α-SMA) and monocyte lineage marker CD11b, and transmission electron microscopy. At one month after keratitis, corneas had no detectible EBM lamina lucida or lamina densa, and the central stroma was packed with myofibroblasts that in some eyes extended to the posterior corneal surface with damage to Descemet's membrane and the endothelium. At one month, a nest of stromal cells

2017 Experimental eye research

17. Identification and antimicrobial susceptibility of microorganisms isolated from severe corneal ulcers of dogs in Thailand Full Text available with Trip Pro

Identification and antimicrobial susceptibility of microorganisms isolated from severe corneal ulcers of dogs in Thailand This study aims to determine the microbiological profile and risk factors associated with antimicrobial-resistant bacteria in canine severe corneal ulcers. Thirty-two corneal and conjunctival swabs were collected from dogs with diagnosed severe corneal ulcers that presented to Prasu-Arthorn veterinary teaching hospital in Nakhon Pathom, Thailand from June 2015 to June 2016 (...) active against staphylococci (81.3% susceptible). The width (P=0.02) and the depth (P=0.04) of ulcers predicted greater risk of yielding resistant bacteria. The identification of antimicrobial-resistant bacteria prompts practitioners to be prudent when choosing ophthalmic antibiotics for severe corneal ulcers.

2018 The Journal of Veterinary Medical Science

18. Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Neurotrophic Corneal Ulcer Full Text available with Trip Pro

Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Neurotrophic Corneal Ulcer Platelet-rich plasma (PRP) is an autologous blood product without preservatives and rich in proteins and growth factors which make it possible for cells to differentiate, proliferate, and migrate, thus stimulating healing and regeneration of tissues. The aim of this study was to evaluate the efficiency of autologous platelet-rich plasma in the treatment of neurotrophic keratopathy.The study group consists (...) of 25 patients with nonhealing corneal ulcers due to herpes simplex or herpes zoster infection and facial nerve or trigeminal nerve paralysis as a result of a neurosurgical operation caused by a tumour or stroke. The patients were given autologous platelet-rich plasma drops five times a day and additionally preservative-free artificial tears and a vitamin A ointment at night for maximum 3 months. The following were evaluated: best corrected visual acuity (BCVA), healing of corneal surface

2018 Journal of ophthalmology

19. Village-Integrated Eye Worker trial (VIEW): rationale and design of a cluster-randomised trial to prevent corneal ulcers in resource-limited settings. Full Text available with Trip Pro

Village-Integrated Eye Worker trial (VIEW): rationale and design of a cluster-randomised trial to prevent corneal ulcers in resource-limited settings. Corneal opacity is a leading cause of blindness worldwide. In resource-limited settings, untreated traumatic corneal abrasions may result in infection and ultimately, opacity. Although antimicrobial treatment of corneal ulcers may successfully cure infections, the scarring that accompanies the resolution of infection can still result in visual (...) impairment. Prevention may be the optimal approach for reducing corneal blindness. Studies have employed community health workers to provide prompt administration of antimicrobials after corneal abrasions to prevent infections, but these studies were not designed to determine the effectiveness of such a programme.The Village-Integrated Eye Worker trial (VIEW) is a cluster-randomised trial designed to assess the effectiveness of a community health worker intervention to prevent corneal ulcers. Twenty-four

2018 BMJ open Controlled trial quality: uncertain

20. Corneal abrasions

are at increased risk of Pseudomonas infection. Most abrasions heal within 1 or 2 days and have very few sequelae. Larger defects, or those associated with contact lens use, should have ophthalmological follow-up in 1 to 2 days to ensure healing. Complications are rare but include corneal ulceration and keratitis. Definition Corneal abrasions are corneal epithelial defects. They are common and are typically caused by mechanical trauma from external objects such as fingernails and branches, foreign bodies (...) Corneal abrasions Corneal abrasions - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Corneal abrasions Last reviewed: February 2019 Last updated: March 2018 Summary Onset is usually sudden, and typical symptoms include a foreign body sensation (even if none present), photophobia, excessive tearing, blepharospasm, and blurry vision. Treatment involves adequate analgesia and topical antibiotics. Contact lens wearers

2018 BMJ Best Practice

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