How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

26,777 results for

Cornea

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

121. The Effects of Distance Between the Corneal Apex and the Inner and Outer Corneal Wound Edges on Corneal Astigmatism After Cataract Surgery. (Abstract)

, the mean change in anterior, posterior, and total corneal astigmatism at 1 week and anterior astigmatism at 1 month were statistically significantly greater in the inner incision close group than in the inner incision far group. In the outer incision distance group, the mean change in anterior corneal astigmatism at 1 week was statistically significantly greater in the close group than in the far group. Surgically induced astigmatism (SIA) of the posterior cornea showed a statistically significant (...) The Effects of Distance Between the Corneal Apex and the Inner and Outer Corneal Wound Edges on Corneal Astigmatism After Cataract Surgery. To compare the effects of the distance from the inner and outer corneal incision wounds to the corneal apex on the changes in corneal astigmatism after cataract surgery.Seventy-two eyes with anterior corneal astigmatism less than 2.50 diopters (D) were evaluated. The distance between the incision wound and the corneal apex was measured using the Pentacam

2017 Journal of Refractive Surgery

122. Connective tissue growth factor is not necessary for haze formation in excimer laser wounded mouse corneas. Full Text available with Trip Pro

Connective tissue growth factor is not necessary for haze formation in excimer laser wounded mouse corneas. We sought to determine if connective tissue growth factor (CTGF) is necessary for the formation of corneal haze after corneal injury. Mice with post-natal, tamoxifen-induced, knockout of CTGF were subjected to excimer laser phototherapeutic keratectomy (PTK) and the corneas were allowed to heal. The extent of scaring was observed in non-induced mice, heterozygotes, and full homozygous (...) knockout mice and quantified by macrophotography. The eyes from these mice were collected after euthanization for re-genotyping to control for possible Cre-mosaicism. Primary corneal fibroblasts from CTGF knockout corneas were established in a gel plug assay. The plug was removed, simulating an injury, and the rate of hole closure and the capacity for these cells to form light reflecting cells in response to CTGF and platelet-derived growth factor B (PDGF-B) were tested and compared to wild-type cells

2017 PLoS ONE

123. 3D Functional Corneal Stromal Tissue Equivalent Based on Corneal Stromal Stem Cells and Multi-Layered Silk Film Architecture. Full Text available with Trip Pro

3D Functional Corneal Stromal Tissue Equivalent Based on Corneal Stromal Stem Cells and Multi-Layered Silk Film Architecture. The worldwide need for human cornea equivalents continues to grow. Few clinical options are limited to allogenic and synthetic material replacements. We hypothesized that tissue engineered human cornea systems based on mechanically robust, patterned, porous, thin, optically clear silk protein films, in combination with human corneal stromal stem cells (hCSSCs), would (...) generate 3D functional corneal stroma tissue equivalents, in comparison to previously developed 2D approaches. Silk film contact guidance was used to control the alignment and distribution of hCSSCs on RGD-treated single porous silk films, which were then stacked in an orthogonally, multi-layered architecture and cultured for 9 weeks. These systems were compared similar systems generated with human corneal fibroblasts (hCFs). Both cell types were viable and preferentially aligned along the biomaterial

2017 PLoS ONE

124. Re: Hersh et al.: U.S. multicenter clinical trial of corneal collagen crosslinking for treatment of corneal ectasia after refractive surgery (Ophthalmology. 2017;124:1475-1484). (Abstract)

Re: Hersh et al.: U.S. multicenter clinical trial of corneal collagen crosslinking for treatment of corneal ectasia after refractive surgery (Ophthalmology. 2017;124:1475-1484). 29784099 2018 05 22 1549-4713 125 6 2018 Jun Ophthalmology Ophthalmology Re: Hersh et al.: U.S. multicenter clinical trial of corneal collagen crosslinking for treatment of corneal ectasia after refractive surgery (Ophthalmology. 2017;124:1475-1484). e39 S0161-6420(17)33642-4 10.1016/j.ophtha.2018.01.037 De Bernardo

2018 Ophthalmology Controlled trial quality: uncertain

125. [MITOCHONDRIA-TARGETED ANTIOXIDANTS IN THE PREVENTION OF THE CORNEA EROSION WHEN PERFORMING SURGERY UNDER GENERAL ANESTHESIA.] (Abstract)

[MITOCHONDRIA-TARGETED ANTIOXIDANTS IN THE PREVENTION OF THE CORNEA EROSION WHEN PERFORMING SURGERY UNDER GENERAL ANESTHESIA.] Despite the use of modern methods of prevention, at least 10% of patients operated on for ophthalmic indications not develop corneal erosion as the indirect complication of general anesthesia.To reduce the number of ophthalmic complications of general anesthesia by prophylactic use of new mito- chondria-targeted antioxidants - Vizomitin (eye drops).70 patients, which (...) was supposed to perform the average duration of operations under general anesthesia were randomized into 3 groups depending on the method specific (pharmacological) prevention of corneal erosions: (1) control (specic (pharmacological) prevention was not carried out), (2), using preparation "natural tear, and (3) "Vizomitin" preparation. Postoperative biomicroscopy was performed to assess the condition of the cornea, tear film stability was measured and the height of the tear meniscus.When using eye drops

2018 Anesteziologiia i reanimatologiia Controlled trial quality: uncertain

126. Mitochondria-targeted antioxidant SKQ1 protects cornea from oxidative damage induced by ultraviolet irradiation and mechanical injury. Full Text available with Trip Pro

Mitochondria-targeted antioxidant SKQ1 protects cornea from oxidative damage induced by ultraviolet irradiation and mechanical injury. Cornea protects the eye against natural and anthropogenic ultraviolet (UV) damage and mechanical injury. Corneal incisions produced by UV lasers in ophthalmic surgeries are often complicated by oxidative stress and inflammation, which delay wound healing and result in vision deterioration. This study trialed a novel approach to prevention and treatment (...) of iatrogenic corneal injuries using SkQ1, a mitochondria-targeted antioxidant approved for therapy of polyethiological dry eye disease.Rabbit models of UV-induced and mechanical corneal damage were employed. The animals were premedicated or treated with conjunctival instillations of 7.5 μM SkQ1. Corneal damage was assessed by fluorescein staining and histological analysis. Oxidative stress in cornea was monitored by measuring malondialdehyde (MDA) using thiobarbituric acid assay. Total antioxidant activity

2018 BMC Ophthalmology

127. Assessment of Topical Therapies for Improving the Optical Clarity Following Stromal Wounding in a Novel Ex Vivo Canine Cornea Model. Full Text available with Trip Pro

Assessment of Topical Therapies for Improving the Optical Clarity Following Stromal Wounding in a Novel Ex Vivo Canine Cornea Model. To evaluate the effect of topical suberanilohydroxamic acid (SAHA) and 5-methyl-1-phenyl-2[1H]-pyridone (pirfenidone) on the degree of corneal haze in the stromal wounded ex vivo canine cornea.Twenty-four corneoscleral rims from normal dogs were uniformly wounded with an excimer laser and placed into culture medium with an air-liquid interface. The control group (...) , and 5.92 mm2 in the pirfenidone group, which is significant (P < 0.01).Stromal-wounded ex vivo canine corneas exhibited greater optical clarity when treated with SAHA and pirfenidone than when placebo treated at 21 days. There was no significant difference in epithelialization rate between groups. Corneal contour was correlated with geographic haze distribution.

2018 Investigative Ophthalmology & Visual Science

128. Corneal dysplastic melanosis associated with recurrent corneal erosions: A case report. Full Text available with Trip Pro

Corneal dysplastic melanosis associated with recurrent corneal erosions: A case report. Pigmented lesions of conjunctiva and cornea can be observed in various conditions, from the benign nevus to malignant melanoma. Pigmented acquired melanosis (PAM) is one of them, which is a neoplastic proliferation with malignant transformation potential of melanocytes. However, to our knowledge, there has been no report as to a disturbance of corneal barrier function caused by PAM. Here we report a case (...) of corneal PAM which led to recurrent corneal erosions.A 60-year-old woman was referred with a 4-month history of intractable recurrent epithelial erosions in the left eye. She denied any history of ocular trauma or surgery. Slit-lamp examination showed small epithelial defects and loose epithelium of overlying pigmented corneal lesions. The pigmentations were scattered in the corneal epithelial layer, from limbus to the central cornea.Conservative treatment with therapeutic contact lens and oral

2018 Medicine

129. Accuracy of Tonopen vs. iCare in Human Cadaveric Eyes with Edematous Corneas Over a Wide Range of Intraocular Pressures. (Abstract)

Accuracy of Tonopen vs. iCare in Human Cadaveric Eyes with Edematous Corneas Over a Wide Range of Intraocular Pressures. [Black Square] [Black Square] [Black Square] [Black Square].

2018 Journal of Glaucoma

130. Corneal Neurotization Improves Ocular Surface Health in a Novel Rat Model of Neurotrophic Keratopathy and Corneal Neurotization. Full Text available with Trip Pro

Corneal Neurotization Improves Ocular Surface Health in a Novel Rat Model of Neurotrophic Keratopathy and Corneal Neurotization. Corneal neurotization is a novel surgical procedure to reinnervate the cornea in patients with neurotrophic keratopathy (NK). We developed a rat model of NK and corneal neurotization to further investigate corneal neurotization as a treatment to improve maintenance and healing of the corneal epithelium.Thy1-GFP+ Sprague Dawley rats were used to develop the model (...) . Corneal denervation was performed via stereotactic electrocautery of the ophthalmomaxillary branch of the trigeminal nerve. Corneal neurotization was performed by guiding donor sensory axons from the contralateral infraorbital nerve into the cornea via two nerve grafts. Corneal imaging, including nerve density measurements and retrograde labeling were performed to validate the model. In vivo assays of corneal maintenance and repair were used to examine whether treatment with corneal neurotization

2018 Investigative Ophthalmology & Visual Science

131. Effect of dexamethasone intravitreal implant (Ozurdex®) on corneal endothelium in retinal vein occlusion patients : Corneal endothelium after dexamethasone implant injection. Full Text available with Trip Pro

Effect of dexamethasone intravitreal implant (Ozurdex®) on corneal endothelium in retinal vein occlusion patients : Corneal endothelium after dexamethasone implant injection. To assess corneal endothelial cell changes after intravitreal dexamethasone (DEX) implant (Ozurdex®) injection in patients with macular edema secondary to retinal vein occlusion (RVO).Twenty-two eyes of 22 patients were assessed prospectively after intravitreal 0.7 mg DEX implant injection. Twenty-two eyes of 22 healthy (...) volunteers served as control group. Corneal endothelial cell parameters including endothelial cell density (ECD), coefficient of variation of cell size (CV), percentage of hexagonality (Hex) and central corneal thickness (CCT) were analyzed before and 1 and 3 months after injection by specular microscopy. The results of the study were compared statistically.There were 17 (77.3%) patients with branch RVO and 5 (22.7%) patients with central RVO. Mean intraocular pressure (IOP) was 14.73 mmHg before

2018 BMC Ophthalmology

132. Modified Corneal EA With Middle LKP for Severe Corneal Burn

Modified Corneal EA With Middle LKP for Severe Corneal Burn Modified Corneal EA With Middle LKP for Severe Corneal Burn - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Modified Corneal EA With Middle LKP (...) for Severe Corneal Burn The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03498846 Recruitment Status : Recruiting First Posted : April 17, 2018 Last Update Posted : July 9, 2018 See Sponsor: Sun Yat-sen University Information

2018 Clinical Trials

133. OCT in Diagnosis of Irregular Corneas

, Oregon Health and Science University Study Details Study Description Go to Brief Summary: This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions. The primary goal will be achieved by using optical coherence tomography (OCT) to: Develop an OCT-based system to classify and evaluate corneal-shape irregularities. Develop OCT metrics for more (...) sensitive detection of keratoconus progression. Develop OCT-and-topography guided phototherapeutic keratectomy (PTK) for irregular corneas. Condition or disease Intervention/treatment Keratoconus Corneal Opacity Corneal Dystrophy Device: Optical Coherence Tomography Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 445 participants Observational Model: Case-Control Time Perspective: Prospective Official Title: Optical Coherence Tomography-Aided

2018 Clinical Trials

134. Corneal neurotisation by great auricular nerve transfer and scleral-corneal tunnel incisions for neurotrophic keratopathy. (Abstract)

Corneal neurotisation by great auricular nerve transfer and scleral-corneal tunnel incisions for neurotrophic keratopathy. Medical management of neurotrophickeratopathy is challenging and costly. Supra-orbital nerve transfer to thecornea has proven effective for management of keratopathy, but yieldsconsiderable donor site morbidity. Herein, a novel technique for reinnervationof the anaesthetic cornea is presented and early results characterised.Sensory fibres of the ipsilateral greatauricular (...) nerve were directed via an interposition graft to the anteriorcorneal stroma using scleral-corneal tunnel incisions in two patients withgrade III neurotrophic keratopathy.Improvements in visual acuity, cornealpachymetry, corneal esthesiometry, and corneal neurotisation as assessed by invivo confocal microscopy were observed within nine months of surgery in bothpatients.Corneal neurotisation by interposition grafttransfer of great auricular nerve fibres via scleral-corneal tunnel incisionsappears

2018 British Journal of Ophthalmology

135. Transepithelial versus epithelium-off corneal crosslinking for corneal ectasia. (Abstract)

Transepithelial versus epithelium-off corneal crosslinking for corneal ectasia. This review compared the clinical results of transepithelial corneal crosslinking (CXL) to epithelium-off (epi-off) CXL in progressive corneal ectasia using a metaanalysis. The Cochrane databases and Medline were searched for randomized controlled trials (RCTs). Seven RCTs involving 505 eyes that met the eligibility criteria were identified. The epi-off CXL group showed significantly better outcomes in postoperative (...) changes in maximum keratometry (K) during 1-year observation periods. Transepithelial CXL resulted in significantly greater post-treatment central corneal thickness and best spectacle-corrected visual acuity (BSCVA). The presence of a postoperative demarcation line was significantly more frequent after epi-off CXL than that after transepithelial CXL. No statistically significant difference was found between other parameters. Although patients in the transepithelial CXL group demonstrated a greater

2018 Journal of cataract and refractive surgery

136. Factors Associated with Graft Rejection in the Cornea Preservation Time Study. Full Text available with Trip Pro

Factors Associated with Graft Rejection in the Cornea Preservation Time Study. To identify factors related to graft rejection following Descemet stripping automated endothelial keratoplasty (DSAEK) in the Cornea Preservation Time Study (CPTS).Cohort study within a multicenter randomized clinical trial.A total of 1330 eyes of 1090 subjects undergoing DSAEK were randomized to receive a donor cornea with preservation time (PT) of 0-7 days (n = 675) or 8-14 days (n = 655) and followed for 3 years

2018 American Journal of Ophthalmology Controlled trial quality: uncertain

137. Brittle cornea syndrome: a case report and review of the literature. Full Text available with Trip Pro

Brittle cornea syndrome: a case report and review of the literature. To report a patient who presented with bluish scleral discoloration, keratoconus, and progressive high myopia.A 6-year-old Chinese female patient presented with a significant bluish discoloration of the sclera in both eyes and extreme corneal thinning with anterior corneal protrusion. General pediatric physical examination was normal for all systems and no genetic disorders known were observed.We aim to highlight (...) the importance of diagnosis and treatment of patients suffering from Brittle cornea syndrome. Timely diagnosis and early provision of protective glasses seem to be the most important step in treating BCS. To our knowledge, this is the first case of BCS being reported in the Asia area.

2018 BMC Ophthalmology

138. Optimization of femtosecond lasers using porcine and human donor corneas before in vivo use. (Abstract)

Optimization of femtosecond lasers using porcine and human donor corneas before in vivo use. To demonstrate a safe and effective method of optimizing a femtosecond laser upon installation or for a new procedure before use on patients. In this case, specifically for optimizing settings for intrastromal corneal pocket creation for the presbyopic small-aperture corneal inlay (Kamra) and deep laser in situ keratomileusis (LASIK) flaps for the presbyopic hydrogel corneal inlay (Raindrop).Keil LASIK (...) pockets for the small-aperture corneal inlay. Further adjustment of settings to 14.0 mm/s pocket at 110% energy was still necessary to optimize pockets. No change in settings was necessary when creating deeper corneal LASIK flaps (ie, the same settings could be used for flaps of 110 μm or 180 μm).After settings were optimized for porcine corneas, further optimization was necessary before successful corneal incisions could be created in vivo for corneal pockets. No further optimization was required

2018 Journal of cataract and refractive surgery

139. TSLP Protects Corneas From Pseudomonas aeruginosa Infection by Regulating Dendritic Cells and IL-23-IL-17 Pathway. Full Text available with Trip Pro

TSLP Protects Corneas From Pseudomonas aeruginosa Infection by Regulating Dendritic Cells and IL-23-IL-17 Pathway. We sought to determine the role of epithelium-produced thymic stromal lymphopoietin (TSLP) and its underlying mechanisms in corneal innate immune defense against Pseudomonas (P.) aeruginosa keratitis.The expression of TSLP and TSLPR in cultured human corneal epithelial cells (HCECs) and mouse corneas was determined by PCR, Western, and/or ELISA. Cellular localization of TSLP (...) receptor (TSLPR) was determined by whole mount confocal microscopy. TSLP-TSLPR signaling was downregulated by neutralizing antibodies and/or small interfering (si)RNA; their effects on the severity of P. aeruginosa-keratitis and cytokine expression were assessed using clinical scoring, bacterial counting, PMN infiltration, and real-time PCR. The role of dendritic cells (DCs) in corneal innate immunity was determined by local DC depletion using CD11c-DTR mice.P. aeruginosa-infection induced

2018 Investigative Ophthalmology & Visual Science

140. Impaired healing of cornea incision injury in a TRPV1-deficient mouse Full Text available with Trip Pro

Impaired healing of cornea incision injury in a TRPV1-deficient mouse The present study attempts to elucidate the role of TRPV1 cation channel receptor on primary repair in an incision-wounded mouse cornea in vivo. Previous study revealed that blocking TRPV1 suppressed myofibroblast formation and expression of transforming growth factor β1 (TGFβ1) in cultured keratocytes or ocular fibroblasts. Male C57BL/6 (wild-type; WT) mice and male C57BL/6 Trpv1-null (KO) mice incurred a full-thickness (...) incision injury (1.8 mm in length, limbus to limbus) in the central cornea of one eye with a surgical blade under general and topical anesthesia. The injury was not sutured. On days 0, 5, and 10, the eyes were enucleated, processed for histology, immunohistochemistry, and real-time RT-PCR gene expression analysis to evaluate the effects of the loss of TRPV1 on primary healing. Electron microscopy observation was also performed to know the effect of the loss of TRPV1 on ultrastructure of keratocytes

2018 Cell and tissue research

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>