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121. Partial thickness cornea tissue from small incision lenticule extraction: A novel patch graft in glaucoma drainage implant surgery. Full Text available with Trip Pro

implantation surgery from August 2015 to January 2017 at the Xiamen Eye Center were randomly divided into 2 groups. Group A (corneal group) included 131 cases (135 eyes), receiving the 3 layers of allogeneic cornea slices as graft. Group B (scleral group) included 124 cases (127 eyes), using the sclera as allograft. The appearance, graft, conjunctiva melting, and tube exposure were the primary observation points.After followed up for 6 to 20 months, a thinner appearance was seen in 3 eyes (2.2 (...) %) in the corneal graft group and 7 eyes (5.5%) in the scleral group. Conjunctiva melted and drainage tube exposed in 0 eyes (0%) in the corneal graft group and 2 eyes (1.6%) in the scleral group. One eye needed repair surgery. There was no statistical difference between the 2 groups (P > .05). After surgery, the intraocular pressure was reduced significantly in both groups (P < .05). The white sclera slice could be seen under the conjunctiva, thereby affecting the cosmetic appearance.The cornea slice acquired

2019 Medicine Controlled trial quality: uncertain

122. Mediators of Corneal Haze Following Implantation of Presbyopic Corneal Inlays. Full Text available with Trip Pro

Mediators of Corneal Haze Following Implantation of Presbyopic Corneal Inlays. To identify protein mediators of corneal haze following presbyopic corneal inlay surgery.Tears were collected from eyes with corneal haze following surgery with a shape-changing corneal inlay. Samples were subjected to quantitative proteomic analysis using iTRAQ and proteins significantly increased or decreased (1.3-fold or more) in haze eyes relative to fellow eyes were identified. Expression ratios were compared (...) to postoperative eyes without corneal haze to identify proteins selectively increased or decreased in corneal haze eyes.Inlay-associated haze occurred in 35% of eyes (6 of 17). Of 1443 unique tear proteins identified, eight proteins were selectively reduced in tears from postoperative haze eyes and one protein selectively increased. Proteins reduced in haze eyes included complement 4a (level relative to nonhaze eyes 0.464, P = 0.037), complement factor H (0.589, P = 0.048), immunoglobulin kappa variable 2-29

2019 Investigative Ophthalmology & Visual Science

123. Treatment of neurotrophic keratopathy with minimally invasive corneal neurotisation: long-term clinical outcomes and evidence of corneal reinnervation. (Abstract)

Treatment of neurotrophic keratopathy with minimally invasive corneal neurotisation: long-term clinical outcomes and evidence of corneal reinnervation. To report clinical outcomes and evidence of corneal innervation in patients with neurotrophic keratopathy (NK) treated with minimally invasive corneal neurotisation (MICN) using a sural nerve graft and donor sensory nerves from the face.Patients undergoing MICN at The Hospital for Sick Children, Toronto, Canada were prospectively recruited. Data (...) on central corneal sensation (CCS, measured with Cochet-Bonnet aesthesiometer), best-corrected visual acuity (BCVA) and corneal epithelial integrity were collected. In four patients who subsequently underwent keratoplasty, immunohistochemical analysis was performed on the corneal explants. One patient underwent magnetoencephalography (MEG) after MICN to characterise the neurophysiological pathways involved.Between November 2012 and February 2017, 19 eyes of 16 patients underwent MICN. Mean follow-up

2019 British Journal of Ophthalmology

124. Angiostrongylus-a technique for removing a rare parasite from the cornea of a child. (Abstract)

Angiostrongylus-a technique for removing a rare parasite from the cornea of a child. We report a case of an Angiostrongylus parasite in the corneal stroma in an 8-year-old boy and our technique for its removal. The parasite was identified on slit-lamp examination. Its location was confirmed on anterior segment optical coherence topography (AS-OCT). The parasite was found on the superficial corneal stroma in the periphery and was removed after lamellar dissection of the cornea following marking

2019 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

125. Corneal Substructure Dosimetry Predicts Corneal Toxicity in Patients with Uveal Melanoma Treated with Proton Beam Therapy. (Abstract)

Gy (RBE) for max dose, and 32 Gy (RBE) for mean dose to the cornea separated patients into groups experiencing and not experiencing toxicity with 90% sensitivity and ≥96% specificity. Bivariate logistic regression indicated that corneal V25, V45, and mean dose independently predicted for toxicity after adjusting for tumor location.Patients receiving PBT for anterior uveal melanomas experience a high rate of GR2+ corneal toxicity due to increased corneal dose. Anterior location and corneal DVH (...) Corneal Substructure Dosimetry Predicts Corneal Toxicity in Patients with Uveal Melanoma Treated with Proton Beam Therapy. The present study examines the relationship between dose to corneal substructures and incidence of corneal toxicity within six months of proton beam therapy (PBT) for uveal melanoma. We aim to develop clinically meaningful dose constraints that can be used to mitigate corneal toxicity.Ninety-two patients were treated with PBT between 2015 and 2017 and evaluated for grade 2

2019 Biology and Physics

126. Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy. Full Text available with Trip Pro

Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy. The diabetic cornea exhibits pathological alterations such as delayed epithelial wound healing and nerve regeneration. We sought to investigate the role of Semaphorin (SEMA) 3C in corneal wound healing and re-innervation in normal and diabetic B6 mice. Wounding induced the expression of SEMA3A, 3C and their receptor Neuropilin (NRP) 2 (...) , but not NRP1 in normal corneal epithelial cells (CECs); this upregulation was suppressed for SEMA3C and NRP2 in diabetic corneas. Injections of Sema3C-specific siRNA and NRP2 neutralizing antibodies in wounded mice resulted in a decrease in the rate of wound healing and regenerating nerve fibers, while exogenous SEMA3C had opposing effects in diabetic corneas. NRP1 neutralization, on the other hand, decreased epithelial wound closure but increased sensory nerve regeneration in diabetic corneas, suggesting

2019 Diabetes

127. Comparing the effects of two different contact lenses on corneal re-epithelialization after corneal collagen cross-linking. Full Text available with Trip Pro

Comparing the effects of two different contact lenses on corneal re-epithelialization after corneal collagen cross-linking. To investigate whether keratoconus (KC) patients who applied the corneal collagen cross-linking (CXL) and two different contact lens (CL) showed any differences in complaints and findings following the CXL.This prospective, comparative, double-blind clinical study involved 60 eyes of 60 patients (38 female and 22 male). At the end of the CXL procedure, CL (Balafilcon (...) A) was inserted in 29 patients (Group-1) while CL with different material content (Hioxifilcon A) designed for therapeutic/bandage purposes were inserted in 31 patients (Group-2).On the 1st and 3th day after the CXL, there were no statistically significant differences between the groups in terms of the postoperative symptoms. On the 3th day after the CXL, all cases of both two groups were found to complete the corneal re-epithelialization. There was more PE ratio in the patients who had allergic

2019 Pakistan Journal Of Medical Sciences Controlled trial quality: uncertain

128. Myh11 Lineage Corneal Endothelial Cells and ASCs Populate Corneal Endothelium. Full Text available with Trip Pro

. Immunostaining and Western blot characterized marker expression and spatial distribution of Myh11-Lin(+) cells in the cornea, and administration of 5-ethynyl-2'-deoxyuridine labeled proliferating cells. ASCs were isolated from epididymal adipose Myh11+ mural cells and treated with cornea differentiation media to evaluate corneal endothelial differentiation potential. Differentiated ASCs were injected into the anterior chamber to test for incorporation into corneal endothelium following scratch injury.A (...) subset of CECs express Myh11, a marker previously thought restricted to only mural cells. Myh11-Lin(+) CECs marked a stable subpopulation of cells in the cornea endothelium. Myh11-Lin(+) ASCs undergo CEC differentiation in vitro and incorporate into injured corneal endothelium.Dystrophy and dysfunction of the corneal endothelium accounts for almost half of all corneal transplants, the maintenance of the cornea endothelium is poorly understood, and there are a lack of mouse models to study specific

2019 Investigative Ophthalmology & Visual Science

129. Gene Expression and Missplicing in the Corneal Endothelium of Patients With a TCF4 Trinucleotide Repeat Expansion Without Fuchs' Endothelial Corneal Dystrophy. Full Text available with Trip Pro

Gene Expression and Missplicing in the Corneal Endothelium of Patients With a TCF4 Trinucleotide Repeat Expansion Without Fuchs' Endothelial Corneal Dystrophy. CTG trinucleotide repeat (TNR) expansion in an intron of the TCF4 gene is the most common genetic variant associated with Fuchs' endothelial corneal dystrophy (FECD). Although several mechanisms have been implicated in the disease process, their exact pathophysiologic importance is unclear. To understand events leading from TCF4 TNR (...) expansion to disease phenotype, we characterized splicing, gene expression, and exon sequence changes in a rare cohort of patients with TNR expansions but no phenotypic FECD (RE+/FECD-).Corneal endothelium and blood were collected from patients undergoing endothelial keratoplasty for non-FECD corneal edema. Total RNA was isolated from corneal endothelial tissue (n = 3) and used for RNASeq. Gene splicing and expression was assessed by Mixture of Isoforms (MISO) and MAP-RSeq software. Genomic DNA

2019 Investigative Ophthalmology & Visual Science

130. Comparison of Surgically Induced Astigmatism and Corneal Morphological Features Between Femtosecond Laser and Manual Clear Corneal Incisions. (Abstract)

Comparison of Surgically Induced Astigmatism and Corneal Morphological Features Between Femtosecond Laser and Manual Clear Corneal Incisions. To assess corneal morphologic changes and surgically induced astigmatism (SIA) following clear corneal incisions (CCIs) created manually or with the Catalys femtosecond laser (Johnson & Johnson Vision, Santa Ana, CA).In this retrospective cohort analysis, patients undergoing femtosecond laser-assisted cataract surgery (FLACS) or manual cataract surgery (...) between June and September 2018 from a single surgical center in Toronto, Canada, were considered for inclusion. Postoperative corneal astigmatism values were compared to preoperative astigmatism indices to determine the SIA at the postoperative 3-month (POM3) mark using the Alpins vector method. Secondary outcomes included postoperative corrected distance visual acuity (CDVA), central corneal thickness (CCT), and CCI morphology parameters.Refractive outcomes from 104 eyes of 61 patients (54 eyes

2019 Journal of Refractive Surgery

131. Assessment of the Association Between In Vivo Corneal Biomechanical Changes After Corneal Cross-linking and Depth of Demarcation Line. (Abstract)

, there was no significant correlation between the change in 1/R and the demarcation line ratio (R2 = .002 and P = .75). However, there was a significant association between the preoperative values of 1/R and the respective change in 1/R (P < .0001). The change in 1/R was inversely proportional to the patient's preoperative 1/R; stiffer corneas (lower values of 1/R) were less affected than less stiff corneas (R2 = .23, P < .0001).CXL is associated with changes in DCRs, suggesting a change in corneal biomechanics (...) Assessment of the Association Between In Vivo Corneal Biomechanical Changes After Corneal Cross-linking and Depth of Demarcation Line. To test for an association between stiffening following corneal cross-linking (CXL) and demarcation line depth.Sixty-six eyes of 66 patients treated with CXL for progressive keratoconus were included. Dynamic corneal response parameters (DCRs) were measured with the Corvis ST (Oculus Optikgeräte GmbH; Wetzlar, Germany) on the day of CXL and after 1 month

2019 Journal of Refractive Surgery

132. Effect of Graft Attachment Status and Intraocular Pressure on DSAEK Outcomes in the Cornea Preservation Time Study. Full Text available with Trip Pro

Effect of Graft Attachment Status and Intraocular Pressure on DSAEK Outcomes in the Cornea Preservation Time Study. To examine the association of donor, recipient, and operative factors on graft dislocation after Descemet stripping automated endothelial keratoplasty (DSAEK) in the Cornea Preservation Time Study (CPTS) as well as the effects of graft dislocation and elevated IOP on graft success and endothelial cell density (ECD) 3 years postoperatively.Cohort study within a multi-center, double (...) -masked, randomized clinical trial.1,090 individuals (1,330 study eyes), median age 70 years, undergoing DSAEK for Fuchs endothelial corneal dystrophy (94% of eyes) or pseudophakic or aphakic corneal edema (6% of eyes). Recipient eyes receiving donor corneal tissue randomized by preservation time (PT) of 0-7 days (N=675) or 8-14 days (N=655) were monitored for early or late graft failure through 3 years. Donor, recipient, operative, and postoperative parameters were recorded including graft

2019 American Journal of Ophthalmology Controlled trial quality: uncertain

133. Intrastromal Lenticule Rotation for Treatment of Astigmatism Up to 10.00 Diopters Ex Vivo in Human Corneas. (Abstract)

and precise for management of regular astigmatism up to 10.00 D ex vivo in human donor corneas. A myopic shift was observed in TCRP. The in vivo corneal remodeling after ISLR warrants investigation. [J Refract Surg. 2019;35(7):451-458.].Copyright 2019, SLACK Incorporated. (...) Intrastromal Lenticule Rotation for Treatment of Astigmatism Up to 10.00 Diopters Ex Vivo in Human Corneas. To evaluate the feasibility of intrastromal lenticule rotation (ISLR) as a novel technique for management of astigmatism up to 10.00 diopters (D).Eighteen human donor corneas were mounted on an artificial anterior chamber. After laser application and dissection, the lenticule was rotated 90° in the intrastromal pocket. Scheimpflug tomography (Pentacam HR; Oculus Optikgeräte GmbH, Wetzlar

2019 Journal of Refractive Surgery

134. Biomechanical Properties of Human Cornea Tested by Two-Dimensional Extensiometry Ex Vivo in Fellow Eyes: PRK Versus SMILE. (Abstract)

Biomechanical Properties of Human Cornea Tested by Two-Dimensional Extensiometry Ex Vivo in Fellow Eyes: PRK Versus SMILE. To investigate the biomechanical properties of the ex vivo human paired corneas after completion of photorefractive keratectomy (PRK) versus small incision lenticule extraction (SMILE) in the same donor.In this experimental study, 13 pairs of human corneas unsuitable for transplantation were equally divided into two groups. Corneal thickness was measured in each eye (...) directly before laser refractive surgery. Corneas from the right eye were treated with PRK and corneas from the left eye with SMILE. All corneas were subjected to a refractive correction of -10.00 diopters (D) sphere and -0.75 D cylinder at 0° with a 7 mm zone, using either surface ablation (PRK) or 130 µm cap (SMILE). For two-dimensional biomechanical measurements, corneoscleral buttons underwent two testing cycles (preconditioning stress-strain curve from 0.03 to 9.0 N and stress-relaxation at 9.0 N

2019 Journal of Refractive Surgery

135. Association of sensitive skin with sensitive corneas and sensitive eyelids. (Abstract)

Association of sensitive skin with sensitive corneas and sensitive eyelids. Sensitive scalp or irritable bowel syndrome has been previously shown to be associated with sensitive skin. We wondered whether sensitive eyelids and sensitive eyes could also be associated with sensitive skin.A cross-sectional epidemiological study was carried out on a representative sample of French people, according to the quota method, using a questionnaire.A total of 2048 subjects were included in the present study

2019 Journal of the European Academy of Dermatology and Venereology

136. Effect of short-term orthokeratology lens or ordinary frame glasses wear on corneal thickness, corneal endothelial cells and vision correction in adolescents with low to moderate myopia. Full Text available with Trip Pro

Effect of short-term orthokeratology lens or ordinary frame glasses wear on corneal thickness, corneal endothelial cells and vision correction in adolescents with low to moderate myopia. We aimed to investigate the effect of short-term orthokeratology lens or frame glasses wear on corneal thickness, corneal endothelial cells and vision correction in adolescents with low to moderate myopia.Data of 100 adolescents with low to moderate myopia were retrospectively analyzed. The patients were (...) assigned into two groups. The experimental group were treated with night-wear orthokeratology lens, and control group were treated with ordinary frame glasses. Follow up was carried out at the 3rd, 6th and 12th months of treatment. The naked-eye vision, diopter, corneal curvature, intraocular pressure, axial length, endothelial cell count and central corneal thickness were examined. Complications within 12 months were observed, and corneal fluorescein staining was graded.The naked-eye vision

2019 BMC Ophthalmology

137. MSCs helped reduce scarring in the cornea after fungal infection when combined with anti-fungal treatment. Full Text available with Trip Pro

MSCs helped reduce scarring in the cornea after fungal infection when combined with anti-fungal treatment. Fungal Keratitis (FK) is an infective keratopathy with extremely high blindness rate. The damaging effect of this disease is not only the destruction of corneal tissue during fungal infection, but also the cornea scar formed during the healing period after infection control, which can also seriously affect a patient's vision. The purpose of the study was to observe the effect of umbilical (...) cord mesenchymal stem cells (uMSCs) on corneal scar formation in FK.The FK mouse model was made according to a previously reported method. Natamycin eye drops were used for antifungal treatment 24 h after modeling. There are four groups involved in the study, including control group, FK group, vehicleinj FK group and uMSCsinj FK group. Mice in uMSCsinj FK group received repeated subconjunctival injections of uMSCs for 3 times at the 1d, 4d and 7d after FK modeling. At 14d, 21d and 28d after trauma

2019 BMC Ophthalmology

138. Conventional corneal cross-linking for treatment of keratoconus

Publication. 2016 Authors' objectives The purpose of corneal cross-linking (CXL), also known as corneal collagen cross-linking, is to increase the biomechanical strength of collagen fibrils of the cornea in order to avoid the progression of keratoconus. Controversy: Conventional CXL (C-CXL) may provide an additional treatment option for patients with progressive keratoconus, possibly reducing the need for more invasive therapy or eventual corneal transplant. However, the procedure may carry risks (...) CXL approaches for improving measures of corneal topography, visual acuity, and refraction in patients with progressive keratoconus? Are C-CXL and alternative CXL approaches safe? Have definitive patient selection criteria been established for C-CXL for the treatment of progressive keratoconus? Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Cornea; Corneal Stroma; Humans; Keratoconus Language Published English Country of organisation

2017 Health Technology Assessment (HTA) Database.

139. [Angiogenesis inhibitors (bevacizumab - ranibizumab) in neovascular glaucoma and corneal neovascularization]

[Angiogenesis inhibitors (bevacizumab - ranibizumab) in neovascular glaucoma and corneal neovascularization] [Angiogenesis inhibitors (bevacizumab - ranibizumab) in neovascular glaucoma and corneal neovascularization] [Angiogenesis inhibitors (bevacizumab - ranibizumab) in neovascular glaucoma and corneal neovascularization] Oubiña M, Pichon-Riviere A,Gentile C Augustovski F, García Martí S, Alcaraz A, Bardach A, Ciapponi A, López A, Rey-Ares L Record Status This is a bibliographic record (...) of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Oubiña M, Pichon-Riviere A,Gentile C Augustovski F, García Martí S, Alcaraz A, Bardach A, Ciapponi A, López A, Rey-Ares L. [Angiogenesis inhibitors (bevacizumab - ranibizumab) in neovascular glaucoma and corneal neovascularization] Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Documentos de Evaluación de Tecnologías

2017 Health Technology Assessment (HTA) Database.

140. Recurrent corneal erosion

(particularly PRK) Symptoms Unilateral sharp pain, typically sudden onset on waking and opening eyes; may also awake patient in middle of night Feeling as if eyelid is stuck to eyeball Lacrimation Photophobia Blurred vision May recur over weeks, months or years Signs Epithelial erosion (usually inferior cornea) stains with fluorescein ‘loose’ edges, ‘slipped rug’ appearance Intra-epithelial microcysts Mild stromal oedema NB: examine both eyes for signs of corneal dystrophy Differential diagnosis Tear (...) . 2014;98(2):166-71 Diez-Feijóo E, Grau AE, Abusleme EI, Durán JA. Clinical presentation and causes of recurrent corneal erosion syndrome: review of 100 patients. Cornea. 2014;33:571-5 Lim CH, Turner A, Lim BX. Patching for corneal abrasion. Cochrane Database Syst Rev. 2016;7:CD004764 Mencucci R, Favuzza E. Management of recurrent corneal erosions: are we getting better? Br J Ophthalmol. 2014;98:150-1 Watson SL, Lee MH, Barker NH. Interventions for recurrent corneal erosions. Cochrane Database Syst Rev

2018 College of Optometrists

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