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101. In situ cornea harvesting through the Red Cross Organization: a new approach to relieving severe cornea donor shortage in Chinese eye banks Full Text available with Trip Pro

In situ cornea harvesting through the Red Cross Organization: a new approach to relieving severe cornea donor shortage in Chinese eye banks Corneal diseases are currently the second main cause of blindness in China. Although most of the corneal blindness could be treated by corneal transplantation, only about 10 000 operations were carried out each year owing to the severe shortage of corneal donors and limited eye bank programs. A feasible cornea donation program was established through (...) the organization of the Red Cross, and in situ corneal removal techniques were developed to avoid conflicts with Chinese traditions of keeping the deceased intact. The number of donated corneas, which had a safe and secure quality, increased significantly year by year.

2017 International journal of ophthalmology

102. Comparison of seropositivity of human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and syphilis among Hospital Cornea Retrieval Programme-Donors versus voluntary cornea donors at a large eye bank in Eastern India Full Text available with Trip Pro

Comparison of seropositivity of human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and syphilis among Hospital Cornea Retrieval Programme-Donors versus voluntary cornea donors at a large eye bank in Eastern India To compare the serology profile of donors from Hospital Cornea Retrieval Programme-donors (HCRP-D) and voluntary cornea donors (VC-D) from a large eye bank in Eastern India.This is a retrospective analysis of donor details from January 2011 to December 2016. Donor

2017 Indian journal of ophthalmology

103. Corneal crosslinking for keratoconus and corneal crosslinking for other corneal thinning disorders

that CXL stabilizes the cornea. With keratoconus patients, CXL treatment was shown to produce statistically significant improvements in all outcomes considered except pachymetry. The studies reporting mixed disease groups showed less overall improvement in most measures but still demonstrated significant improvement in BCVA, UCVA, and pachymetry. Both of the included RCTs reported that CXL resulted in stabilization of corneal thinning. A budget impact analysis based on Alberta costs and global (...) Corneal crosslinking for keratoconus and corneal crosslinking for other corneal thinning disorders Corneal crosslinking for keratoconus and corneal crosslinking for other corneal thinning disorders Corneal crosslinking for keratoconus and corneal crosslinking for other corneal thinning disorders Leggett L, Hosein S, Lorenzetti D, Rose S, Clement F Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality

2012 Health Technology Assessment (HTA) Database.

104. Relationship between novel intraocular pressure measurement from Corvis ST and central corneal thickness and corneal hysteresis. (Abstract)

Relationship between novel intraocular pressure measurement from Corvis ST and central corneal thickness and corneal hysteresis. Corvis ST (CST) yields biomechanical corrected IOP (bIOP) which is purported to be less dependent on biomechanical properties. In our accompanied paper, it was suggested that the repeatability of bIOP is high. The purpose of the current study was to assess the relationship between intraocular pressure (IOP) measured with CST and central corneal thickness (CCT (...) ) and corneal hysteresis (CH), in comparison with IOP measured with Goldmann applanation tonometry (GAT) and the ocular response analyzer (ORA).A total of 141 eyes from 141 subjects (35 healthy eyes and 106 glaucomatous eyes) underwent IOP measurements with GAT, CST and ORA. The relationships between IOP measurements (ORA-IOPg, ORA-IOPcc, CST-bIOP and GAT IOP) and biomechanical properties (CCT, CH and corneal resistance factor (CRF)) were analysed using the linear regression analysis.IOPg, IOPcc and GAT IOP

2019 British Journal of Ophthalmology

105. Differential effects of primary disease and corneal vascularisation on corneal transplant rejection and survival. (Abstract)

Differential effects of primary disease and corneal vascularisation on corneal transplant rejection and survival. To investigate the relative risk of pretransplant corneal vascularisation on rate of rejection and graft failure within 5 years of surgery when categorised by indication for transplantation.We analysed all adults recorded in the UK transplant registry who had a first cornea transplant for keratoconus (KC), pseudophakic bullous keratopathy (PBK) or previous infection (viral/bacterial (...) /fungal/protozoan) between 1999 and 2017. We analysed the number of quadrants of the recipient cornea vascularised before transplant and type of vascularisation, the interval post-transplant to rejection, if any, and the outcome at 5 years post-transplant. Risk factors for rejection and transplant failure were modelled by multivariable risk-adjusted Cox regression.Corneal vascularisation was recorded in 10%, 25% and 67% of patients with KC, PBK and infection, respectively. Individuals with PBK had

2019 British Journal of Ophthalmology

106. Development and validation of a new intraocular pressure estimate for patients with soft corneas. (Abstract)

Development and validation of a new intraocular pressure estimate for patients with soft corneas. To introduce and clinically validate a new method of estimating intraocular pressure (IOP) in patients with keratoconus and soft corneas with the aim of significantly reducing dependence on corneal biomechanics.Vincieye Clinic, Milan, Italy, and Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Brazil.Retrospective case series.This study comprised participants enrolled at two (...) ). Furthermore, the bIOPs predictions were significantly less affected by corneal thickness and patient age than the Scheimpflug analyzer IOP.The bIOPs algorithm was more reliable at estimating the IOP in eyes with a soft cornea and was validated for use in eyes with keratoconus.Copyright © 2019 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

2019 Journal of cataract and refractive surgery

107. Phacoemulsification With 3.0 and 2.0 mm Opposite Clear Corneal Incisions for Correction of Corneal Astigmatism. (Abstract)

Phacoemulsification With 3.0 and 2.0 mm Opposite Clear Corneal Incisions for Correction of Corneal Astigmatism. To compare the effect of 3.0 and 2.0 mm opposite clear corneal incisions (OCCIs) in phacoemulsification on reduction of preexisting corneal astigmatism, and their impact on corneal aberrations.This study is a prospective randomized controlled study that included 140 patients with age-related cataract and regular corneal astigmatism ≥0.75 diopter (D). Phacoemulsification was performed (...) using on-meridian 3.0 or 2.0 mm corneal incision with or without an OCCI. Cases were divided into 4 groups: 3.0 mm OCCIs, 3.0 mm single clear corneal incision (3.0 mm SCCI), 2.0 mm OCCIs, and 2.0 mm SCCI. Keratometry and topography were performed at 3 months postoperatively. The variations in corneal astigmatism and aberrations were recorded. Surgically induced astigmatism was calculated using vector analysis.The corneal astigmatism reduction was 0.61 ± 0.38 D in the 3.0 mm OCCIs group

2019 Cornea Controlled trial quality: uncertain

108. [Incipient observation of cornea astigmatism after combined cataract phacoemulsification and Callisto Eye-assisted arcuate keratotomy]. (Abstract)

phacoemulsification and Callisto Eye-assisted arcuate keratotomy were performed for the experimental group with the depth and length of the corneal arcuate incision differing in subgroups, while only cataract phacoemulsification was performed for the control group. The complications on and after the surgery were observed and the change of cornea astigmatism and uncorrected visual acuity in three months after surgery were recorded. Independent sample t test was used for statistical analysis. Results: A total (...) [Incipient observation of cornea astigmatism after combined cataract phacoemulsification and Callisto Eye-assisted arcuate keratotomy]. Objective: To research the change of cornea astigmatism after combined cataract phacoemulsification and Callisto Eye-assisted arcuate keratotomy and to assess the effectiveness and safety of this surgery for improving patients' uncorrected visual acuity. Methods: Prospective interventional non-randomized controlled study. Consecutive cataract patients

2019 [Zhonghua yan ke za zhi] Chinese journal of ophthalmology Controlled trial quality: uncertain

109. Quantitative evaluation of visual function in patients with cornea verticillata associated with Fabry disease. (Abstract)

Quantitative evaluation of visual function in patients with cornea verticillata associated with Fabry disease. To evaluate the visual function of patients with cornea verticillata associated with Fabry disease through quantitative evaluations of contrast sensitivity function and straylight.We enrolled 28 eyes of 14 patients with Fabry disease (mean age, 37.1 ± 17.2  years) and 20 eyes of 20 age-matched healthy controls. Comprehensive ophthalmological examinations were performed and contrast (...) sensitivity and letter contrast sensitivity were measured for all patients, following which the area under the log contrast sensitivity function (AULCSF) was calculated. Straylight was quantified using a straylight metre. Furthermore, subgroup analysis was performed according to the whorl-like pattern of cornea verticillata (mild and typical groups).All 28 eyes showed cornea verticillata. Visual acuity and letter contrast sensitivity values were the same for normal eyes and those with Fabry disease

2019 Acta ophthalmologica

110. Cornea nerve fibre state determines analgesic response to tapentadol in fibromyalgia patients without effective endogenous pain modulation. Full Text available with Trip Pro

Cornea nerve fibre state determines analgesic response to tapentadol in fibromyalgia patients without effective endogenous pain modulation. Tapentadol is a centrally acting analgesic with μ-agonistic activity combined with noradrenaline reuptake inhibition. Its mechanism of action relies on improvement of descending pain inhibition. In the current study, tapentadol's ability to enhance conditioned pain modulation (CPM, an experimental measure of descending pain inhibition) was evaluated (...) in fibromyalgia patients with absent or reduced CPM responses.A total of 34 fibromyalgia patients completed this double-blind trial. Patients were randomized to receive treatment with tapentadol sustained-release or placebo for a 3-month period with 1-month follow-up. At baseline, the cornea nerve fibre state (CNFS) was quantified to determine the presence of nerve fibre pathology and assess its value in the prediction of the analgesic response.Tapentadol significantly increased CPM responses during treatment

2019 European Journal of Pain Controlled trial quality: predicted high

111. Lassa Virus Targeting of Anterior Uvea and Endothelium of Cornea and Conjunctiva in Eye of Guinea Pig Model. Full Text available with Trip Pro

Lassa Virus Targeting of Anterior Uvea and Endothelium of Cornea and Conjunctiva in Eye of Guinea Pig Model. Lassa virus (LASV), a hemorrhagic fever virus endemic to West Africa, causes conjunctivitis in patients with acute disease. To examine ocular manifestations of LASV, we histologically examined eyes from infected guinea pigs. In fatal disease, LASV immunostaining was most prominent in the anterior uvea, especially in the filtration angle, ciliary body, and iris and in and around vessels (...) in the bulbar conjunctiva and peripheral cornea, where it co-localized with an endothelial marker (platelet endothelial cell adhesion molecule). Antigen was primarily associated with infiltration of T-lymphocytes around vessels in the anterior uvea and with new vessel formation at the peripheral cornea. In animals that exhibited clinical signs but survived infection, eyes had little to no inflammation and no LASV immunostaining 6 weeks after infection. Overall, in this model, LASV antigen was restricted

2019 Emerging Infectious Diseases

112. Overexpression of MMPs in Corneas Requiring Penetrating and Deep Anterior Lamellar Keratoplasty. Full Text available with Trip Pro

keratoplasty) and 6 normal control corneas.Luminex-based expression analysis revealed a significant overexpression of four of the nine MMPs tested (MMP2, MMP8, MMP12, and MMP13) in patient samples compared to control. Significant overexpression of MMP1, MMP2, MMP8, MMP12, and MMP13 was observed in diseased corneas with neovascularization compared with diseased corneas without neovascularization. Overexpression of MMP1, MMP2, MMP8, MMP12, and MMP13 also corresponded with the levels of corneal fibrosis (...) . Finally, reduced expression of MMP3 was detected in keratoconus patients.Multiple MMPs are expressed in the corneas of patients with chronic disease requiring keratoplasty even when the pathologic process appears to be clinically inactive. In particular, the expression of several MMPs (MMP2, MMP8, MMP12, and MMP13) is positively associated with increased levels corneal fibrosis and neovascularization.

2019 Investigative Ophthalmology & Visual Science

113. Enhancing Rose Bengal-Photosensitized Protein Crosslinking in the Cornea. Full Text available with Trip Pro

Enhancing Rose Bengal-Photosensitized Protein Crosslinking in the Cornea. Rose bengal (RB)-photosensitized protein crosslinking has been proposed for several applications in the eye. This study identifies oxygen-dependent and oxygen-independent mechanistic pathways in cornea for RB-photosensitized crosslinking to enhance its efficiency for ocular treatments.Rabbit corneas ex vivo were stained with 1 mM RB and irradiated at 532 nm. RB photobleaching, measured by spectrophotometry and linear (...) tensile strength testing, were performed with and without oxygen present. The effects of sodium azide, D2O, arginine, and ascorbate were used to discriminate between mechanisms involving energy transfer (forming singlet oxygen) and electron transfer (forming radical ions). The influence of corneal depth on RB photobleaching was determined using inclined corneal incisions.RB photobleaching was greater in the presence than the absence of oxygen, enhanced by D2O and partially inhibited by azide

2019 Investigative Ophthalmology & Visual Science

114. Long-term Outcomes of a New Surgical Technique for Corneal Remodeling in Corneal Ectasia. (Abstract)

Long-term Outcomes of a New Surgical Technique for Corneal Remodeling in Corneal Ectasia. To analyze the outcomes of a new technique (corneal remodeling) to treat corneal ectasia.Sixty-nine cases that underwent corneal remodeling were analyzed. Anesthetic drops were instilled and a femtosecond laser platform was used to perform an 8-mm diameter keratectomy (180°, 270°, or 360°). Once ablation was completed, the edges of the resection were sutured with 8 to 12 interrupted stitches.Three-year (...) moderately to statistically significant (P < .05 to < .0000001).Corneal remodeling is a safe technique that produces corneal flattening, reduction of anterior chamber depth, and decreased optical aberrations. It also offers a possibility to perform complementary refractive procedures. [J Refract Surg. 2019;35(4):261-267.].Copyright 2019, SLACK Incorporated.

2019 Journal of Refractive Surgery

115. Multiple Linear Regression Analysis of the Impact of Corneal Epithelial Thickness on Refractive Error Post Corneal Refractive Surgery. (Abstract)

Multiple Linear Regression Analysis of the Impact of Corneal Epithelial Thickness on Refractive Error Post Corneal Refractive Surgery. To evaluate the influence of corneal epithelial thickness (CET) on the deviation from the targeted refraction [refractive error (RE)] post corneal refractive surgery.Retrospective, single-center, cross-sectional study.This study involved 211 eyes of 211 patients who previously underwent laser-assisted in situ keratomileusis (LASIK) or epipolis LASIK (...) for the correction of myopia and myopic astigmatism from August 2000 to May 2014 at the Baptist Eye Institute, Kyoto, Japan, and who subsequently underwent examination of CET via optical coherence tomography imaging of 17 zones (central: n=1 zone, paracentral: n=8 zones, and mid-peripheral: n=8 zones) within a 6.0-mm-diameter area of the central cornea from April 2014 to February 2015. The relationship between CET and RE was evaluated using Spearman's coefficient in 5 parameters: CET in the 1) central, 2

2019 American Journal of Ophthalmology

116. Comparison of changes in corneal endothelial cell density and central corneal thickness between conventional and femtosecond laser-assisted cataract surgery: a randomised, controlled clinical trial. Full Text available with Trip Pro

Comparison of changes in corneal endothelial cell density and central corneal thickness between conventional and femtosecond laser-assisted cataract surgery: a randomised, controlled clinical trial. To identify changes in endothelial cell density (ECD) and central corneal thickness (CCT) in eyes undergoing femtosecond laser-assisted cataract surgery (FLACS) compared with conventional phacoemulsification surgery (CPS).This is an intraindividual randomised, controlled clinical trial. One eye (...) was randomised to receive FLACS, while the contralateral eye of the same patient received CPS. The femtosecond laser pretreatment included creating main and side-port corneal incisions, capsulotomy and lens fragmentation. Non-contact endothelial cell microscopy and pachymetry were performed preoperatively and at postoperative day 1, week 1, month 1 and month 3.A total of 134 paired eyes from 67 patients were included in the analysis. ECD was not significantly different between the two groups at either

2019 British Journal of Ophthalmology Controlled trial quality: uncertain

117. Detection of Subclinical Corneal Ectasia Using Corneal Tomographic and Biomechanical Assessments in a Japanese Population. (Abstract)

Detection of Subclinical Corneal Ectasia Using Corneal Tomographic and Biomechanical Assessments in a Japanese Population. To test the detection of subclinical corneal ectasia using integrated Scheimpflug tomography and biomechanical assessment in a Japanese population.This prospective, case-control study included 23 patients with very asymmetric ectasia (VAE) and 70 normal controls. Patients with VAE had defined clinical ectasia in one eye and a fellow eye with normal topography (VAE-NT (...) ). Objective topography for confirming normal topography in VAE-NT cases included having 0% similarity and 0% severity derived from Placido-disk based topography. Scheimpflug-based corneal tomography and corneal biomechanical assessment were performed. The Belin/Ambrósio Enhanced Ectasia Deviation index (BAD-D), Corvis Biomechanical Index (CBI), and Tomographic Biomechanical Index (TBI) were compared and their discriminating ability for detecting ectasia was assessed.For differentiating normal and VAE-NT

2019 Journal of Refractive Surgery

118. Transformation of the Transcriptomic Profile of Mouse Periocular Mesenchyme During Formation of the Embryonic Cornea. Full Text available with Trip Pro

Transformation of the Transcriptomic Profile of Mouse Periocular Mesenchyme During Formation of the Embryonic Cornea. Defects in neural crest development are a major contributing factor in corneal dysgenesis, but little is known about the genetic landscape during corneal development. The purpose of this study was to provide a detailed transcriptome profile and evaluate changes in gene expression during mouse corneal development.RNA sequencing was used to uncover the transcriptomic profile (...) pathways) and transcriptional regulation.Our analyses, for the first time, identify a large number of differentially expressed genes during progressive stages of mouse corneal development. Our data provide a comprehensive transcriptomic profile of the developing cornea. Combined, these data serve as a valuable resource for the identification of novel regulatory networks crucial for the advancement of studies in congenital defects, stem cell therapy, bioengineering, and adult corneal diseases.

2019 Investigative Ophthalmology & Visual Science

119. Brillouin Spectroscopy of Normal and Keratoconus Corneas. Full Text available with Trip Pro

Brillouin Spectroscopy of Normal and Keratoconus Corneas. To investigate the age-dependence of Brillouin spectroscopy of the cornea and to compare normal and keratoconus corneas.Retrospective case-control study STUDY POPULATION: Healthy patients and patients suffering from keratoconus seen at the Institut für Refraktive und Ophthalmo-Chirurgie (IROC) between December 2016 and March 2017.Brillouin frequency shifts of patients of 2 different groups were examined with Brillouin spectroscopy (...) perpendicular to the corneal surface. Group 1 consisted of 47 healthy eyes, whereas group 2 included 36 eyes with keratoconus of unclear progression. Beside Brillouin examinations, corneal tomographies were acquired so that correlations and comparisons between geometrical parameters and Brillouin frequency shifts could be evaluated.Corneal Brillouin frequency shifts averaged over full corneal thickness.A significant correlation between age and central Brillouin frequency shift was identified (p=0.011

2019 American Journal of Ophthalmology

120. Corneal Stromal transplantation with Human-Derived Acellular Dermal Matrix for Pellucid Marginal Corneal Degeneration: A Nonrandomized Clinical Trial. (Abstract)

Corneal Stromal transplantation with Human-Derived Acellular Dermal Matrix for Pellucid Marginal Corneal Degeneration: A Nonrandomized Clinical Trial. To investigate the transparency, biocompatibility, and safety of human-derived acellular dermal matrix for application in corneal stromal transplantation.Twenty-four patients (24 eyes) with pellucid marginal corneal degeneration were enrolled, and intrastromal keratoplasty was performed with human-derived acellular dermal matrix. The ocular (...) symptoms and signs as well as graft characteristics were evaluated at baseline and at 1 day, 1 week, 1 month, 3 months, and 6 months postoperatively. Photography by a slit lamp, topography by Pentacam, anterior segment-optical coherence tomography (AS-OCT), and corneal confocal microscopy were conducted at baseline and during the follow-up period.Postoperative discomfort was relieved during the follow-up period. No abnormal ocular signs were observed at 6 months, indicating the safety of the procedure

2019 Transplantation

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